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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for nr6a1b

Z-value: 0.18

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Transcription factors associated with nr6a1b

Gene Symbol Gene ID Gene Info
nr6a1b
ENSDARG00000014480 nuclear receptor subfamily 6, group A, member 1b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nr6a1bdr11_v1_chr21_+_8198652_81986520.484.3e-02Click!

Activity profile of nr6a1b motif

Sorted Z-values of nr6a1b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr23_-_10175898 0.45 ENSDART00000146185
krt5
keratin 5
chr9_-_7287375 0.18 ENSDART00000128352
mitd1
MIT, microtubule interacting and transport, domain containing 1
chr12_+_33395748 0.18 ENSDART00000129458
fasn
fatty acid synthase
chr8_-_54216499 0.18 ENSDART00000193678
mbd4
methyl-CpG binding domain protein 4
chr2_+_24700922 0.17 ENSDART00000170467
pik3r2
phosphoinositide-3-kinase, regulatory subunit 2 (beta)
chr25_+_7492663 0.16 ENSDART00000166496
cat
catalase
chr5_-_50992690 0.15 ENSDART00000149553
ENSDART00000097460
ENSDART00000192021
hmgcra
3-hydroxy-3-methylglutaryl-CoA reductase a
chr17_-_53348486 0.15 ENSDART00000161183
CABZ01066926.1

chr22_+_24603930 0.14 ENSDART00000180240
ENSDART00000164256
CU655842.1

chr11_+_45219558 0.14 ENSDART00000167828
tmc6b
transmembrane channel-like 6b
chr8_-_49908978 0.14 ENSDART00000172642
agtpbp1
ATP/GTP binding protein 1
chr3_-_40976288 0.13 ENSDART00000193553
cyp3c1
cytochrome P450, family 3, subfamily c, polypeptide 1
chr3_+_12652244 0.12 ENSDART00000165980
abca3b
ATP-binding cassette, sub-family A (ABC1), member 3b
chr3_-_40976463 0.11 ENSDART00000128450
ENSDART00000018676
cyp3c1
cytochrome P450, family 3, subfamily c, polypeptide 1
chr6_+_39836474 0.10 ENSDART00000112637
smarcc2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
chr25_+_17860798 0.10 ENSDART00000146845
pth1a
parathyroid hormone 1a
chr2_-_50225411 0.10 ENSDART00000147117
ENSDART00000000042
mcm6l
MCM6 minichromosome maintenance deficient 6, like
chr24_+_19542323 0.09 ENSDART00000140379
ENSDART00000142830
sulf1
sulfatase 1
chr23_+_27779452 0.09 ENSDART00000134785
kmt2d
lysine (K)-specific methyltransferase 2D
chr20_+_9128829 0.09 ENSDART00000064144
ENSDART00000137450
bpnt1
bisphosphate nucleotidase 1
chr1_-_55118745 0.09 ENSDART00000133915
sertad2a
SERTA domain containing 2a
chr25_+_17860962 0.08 ENSDART00000163153
pth1a
parathyroid hormone 1a
chr1_-_11104805 0.08 ENSDART00000147648
knl1
kinetochore scaffold 1
chr5_+_6892195 0.08 ENSDART00000048201
gb:cr929477
expressed sequence CR929477
chr7_-_31618166 0.08 ENSDART00000111388
igdcc3
immunoglobulin superfamily, DCC subclass, member 3
chr1_-_49947290 0.07 ENSDART00000141476
sgms2
sphingomyelin synthase 2
chr9_+_24095677 0.07 ENSDART00000150443
lrrfip1a
leucine rich repeat (in FLII) interacting protein 1a
chr13_+_713941 0.07 ENSDART00000109737
cox15
cytochrome c oxidase assembly homolog 15 (yeast)
chr23_+_17102960 0.07 ENSDART00000053414
commd7
COMM domain containing 7
chr12_+_30788912 0.06 ENSDART00000160422
aldh18a1
aldehyde dehydrogenase 18 family, member A1
chr6_-_47246948 0.06 ENSDART00000162435
grm4
glutamate receptor, metabotropic 4
chr16_+_48616220 0.06 ENSDART00000004751
ENSDART00000130045
pbx2
pre-B-cell leukemia homeobox 2
chr1_+_57348756 0.05 ENSDART00000063750
b3gntl1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
chr10_-_16868211 0.05 ENSDART00000171755
stoml2
stomatin (EPB72)-like 2
chr18_+_8912113 0.05 ENSDART00000147467
tmem243a
transmembrane protein 243, mitochondrial a
chr3_+_22442445 0.05 ENSDART00000190921
wnk4b
WNK lysine deficient protein kinase 4b
chr6_-_30932078 0.04 ENSDART00000028612
pde4ba
phosphodiesterase 4B, cAMP-specific a
chr14_-_25095808 0.04 ENSDART00000184244
matr3l1.1
matrin 3-like 1.1
chr17_-_40956035 0.04 ENSDART00000124715
si:dkey-16j16.4
si:dkey-16j16.4
chr21_-_32374656 0.04 ENSDART00000112550
mapk9
mitogen-activated protein kinase 9
chr6_+_48618512 0.04 ENSDART00000111190
FAM19A3
si:dkey-238f9.1
chr15_+_22722684 0.04 ENSDART00000156760
grik4
glutamate receptor, ionotropic, kainate 4
chr6_+_41099787 0.04 ENSDART00000186884
fkbp5
FK506 binding protein 5
chr3_+_19299309 0.04 ENSDART00000046297
ENSDART00000146955
ldlra
low density lipoprotein receptor a
chr7_-_15370042 0.03 ENSDART00000128183
ANPEP
si:ch211-276a23.5
chr1_+_17527342 0.03 ENSDART00000139702
ENSDART00000140076
ENSDART00000005593
casp3a
caspase 3, apoptosis-related cysteine peptidase a
chr5_-_11971946 0.03 ENSDART00000166285
si:ch73-47f2.1
si:ch73-47f2.1
chr20_+_4392687 0.03 ENSDART00000187271
im:7142702
im:7142702
chr1_-_49947482 0.03 ENSDART00000143398
sgms2
sphingomyelin synthase 2
chr10_+_29260096 0.03 ENSDART00000088973
sytl2a
synaptotagmin-like 2a
chr21_+_43669943 0.02 ENSDART00000136025
tmlhe
trimethyllysine hydroxylase, epsilon
chr2_+_13694450 0.02 ENSDART00000077259
ENSDART00000189485
ebna1bp2
EBNA1 binding protein 2
chr8_-_14091886 0.02 ENSDART00000137857
si:ch211-229n2.7
si:ch211-229n2.7
chr1_+_17527931 0.02 ENSDART00000131927
casp3a
caspase 3, apoptosis-related cysteine peptidase a
chr22_-_17781213 0.02 ENSDART00000137984
si:ch73-63e15.2
si:ch73-63e15.2
chr25_-_21609645 0.02 ENSDART00000087817
DOCK4 (1 of many)
si:dkey-81e3.1
chr3_+_2669813 0.02 ENSDART00000014205
CR388047.1

chr9_+_27371240 0.02 ENSDART00000060337
tlr20.3
toll-like receptor 20, tandem duplicate 3
chr8_+_22472584 0.02 ENSDART00000138303
si:dkey-23c22.9
si:dkey-23c22.9
chr17_-_37054959 0.01 ENSDART00000151921
dnmt3ab
DNA (cytosine-5-)-methyltransferase 3 alpha b
chr10_-_373575 0.01 ENSDART00000114487
DMPK
DM1 protein kinase
chr9_+_32301456 0.01 ENSDART00000078608
ENSDART00000185153
ENSDART00000144947
hspe1
heat shock 10 protein 1
chr7_+_29461060 0.01 ENSDART00000075721
foxb1b
forkhead box B1b
chr5_+_50879545 0.01 ENSDART00000128402
nol6
nucleolar protein 6 (RNA-associated)
chr5_-_30475011 0.01 ENSDART00000187501
phldb1a
pleckstrin homology-like domain, family B, member 1a
chr19_+_7878122 0.01 ENSDART00000131917
si:dkeyp-85e10.2
si:dkeyp-85e10.2
chr23_-_19953089 0.01 ENSDART00000153828
atp2b3b
ATPase plasma membrane Ca2+ transporting 3b
chr16_-_45235947 0.01 ENSDART00000164436
si:dkey-33i11.4
si:dkey-33i11.4
chr4_-_34480599 0.01 ENSDART00000159602
ENSDART00000182248
si:dkeyp-51g9.4
si:ch211-64i20.3
si:dkeyp-51g9.4
si:ch211-64i20.3
chr11_-_12739532 0.01 ENSDART00000183734
AP1S2
adaptor related protein complex 1 sigma 2 subunit
chr4_-_41196398 0.01 ENSDART00000163401
si:dkeyp-82h4.3
si:dkeyp-82h4.3
chr16_-_46558708 0.01 ENSDART00000128037
si:dkey-152b24.8
si:dkey-152b24.8
chr23_-_19230627 0.01 ENSDART00000007122
guca1b
guanylate cyclase activator 1B
chr13_-_22843562 0.01 ENSDART00000142738
pbld
phenazine biosynthesis like protein domain containing
chr7_-_30639385 0.01 ENSDART00000173618
myo1ea
myosin IE, a
chr3_-_49015203 0.01 ENSDART00000186138
BX769173.2

chr25_+_33939728 0.01 ENSDART00000148537
roraa
RAR-related orphan receptor A, paralog a
chr1_+_29862074 0.01 ENSDART00000133905
ENSDART00000136786
ENSDART00000135252
pcca
propionyl CoA carboxylase, alpha polypeptide
chr15_+_19681718 0.01 ENSDART00000164803
si:dkey-4p15.5
si:dkey-4p15.5
chr17_+_18117358 0.01 ENSDART00000144894
bcl11ba
B cell CLL/lymphoma 11Ba
chr4_-_44509477 0.00 ENSDART00000102949
ENSDART00000135262
si:dkeyp-100h4.1
si:dkeyp-100h4.1
chr12_-_18408566 0.00 ENSDART00000078767
ENSDART00000152748
tom1l2
target of myb1 like 2 membrane trafficking protein
chr2_+_44687147 0.00 ENSDART00000141605
yeats2
YEATS domain containing 2
chr4_-_38829098 0.00 ENSDART00000151932
si:dkey-59l11.10
si:dkey-59l11.10
chr16_-_46558521 0.00 ENSDART00000189406
si:dkey-152b24.8
si:dkey-152b24.8
chr4_-_71267461 0.00 ENSDART00000161219
ENSDART00000151838
si:dkeyp-51g9.4
si:dkeyp-51g9.4
chr4_+_58668661 0.00 ENSDART00000188815
CR388148.2

chr24_-_25256230 0.00 ENSDART00000155780
hhla2b.1
HERV-H LTR-associating 2b, tandem duplicate 1
chr4_-_34775762 0.00 ENSDART00000167262
si:dkey-146m20.14
si:dkey-146m20.14
chr9_+_42270043 0.00 ENSDART00000137435
si:dkey-10c21.1
si:dkey-10c21.1
chr4_-_34776147 0.00 ENSDART00000167498
si:dkey-146m20.14
si:dkey-146m20.14
chr6_+_27418541 0.00 ENSDART00000187410
crocc2
ciliary rootlet coiled-coil, rootletin family member 2
chr8_+_22405477 0.00 ENSDART00000148267
si:dkey-23c22.7
si:dkey-23c22.7
chr15_+_44133972 0.00 ENSDART00000157846
ENSDART00000191082
CU655961.2

chr4_+_67994238 0.00 ENSDART00000160968
si:ch211-133h13.1
si:ch211-133h13.1
chr3_+_1749793 0.00 ENSDART00000149308
si:dkeyp-52c3.7
si:dkeyp-52c3.7
chr4_-_63559311 0.00 ENSDART00000164415
si:dkey-16p6.1
si:dkey-16p6.1
chr4_+_57192681 0.00 ENSDART00000190438
si:dkey-16p6.4
si:dkey-16p6.4
chr4_-_49582758 0.00 ENSDART00000180834
ENSDART00000187608
si:dkey-159n16.2
si:dkey-159n16.2
chr9_-_1970071 0.00 ENSDART00000080608
hoxd10a
homeobox D10a
chr4_+_34119824 0.00 ENSDART00000165637
si:ch211-223g7.6
si:ch211-223g7.6
chr1_-_57629639 0.00 ENSDART00000158984
zmp:0000001289
zmp:0000001289
chr20_+_36730049 0.00 ENSDART00000045948
ncoa1
nuclear receptor coactivator 1
chr12_+_46605600 0.00 ENSDART00000123533
FADS6
fatty acid desaturase 6
chr10_+_37927100 0.00 ENSDART00000172548
bhlha9
basic helix-loop-helix family, member a9
chr4_-_43616331 0.00 ENSDART00000183211
ENSDART00000150240
si:dkey-16p6.4
si:dkey-16p6.4
chr15_+_19682013 0.00 ENSDART00000127368
si:dkey-4p15.5
si:dkey-4p15.5
chr4_+_76973771 0.00 ENSDART00000142978
si:dkey-240n22.3
si:dkey-240n22.3
chr4_+_47782411 0.00 ENSDART00000161728
si:ch211-196h24.2
si:ch211-196h24.2
chr7_+_35268054 0.00 ENSDART00000113842
dpep2
dipeptidase 2
chr20_+_13175379 0.00 ENSDART00000025644
ppp2r5a
protein phosphatase 2, regulatory subunit B', alpha isoform

Network of associatons between targets according to the STRING database.

First level regulatory network of nr6a1b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.0 0.1 GO:0097237 cellular response to antibiotic(GO:0071236) cellular response to toxic substance(GO:0097237)
0.0 0.2 GO:0043551 regulation of lipid kinase activity(GO:0043550) regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.0 0.1 GO:0021910 smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021910) regulation of myotome development(GO:2000290)
0.0 0.1 GO:0003422 growth plate cartilage morphogenesis(GO:0003422) chondrocyte intercalation involved in growth plate cartilage morphogenesis(GO:0003428)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 GO:0045095 keratin filament(GO:0045095)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0043140 ATP-dependent 3'-5' DNA helicase activity(GO:0043140) single-stranded DNA-dependent ATP-dependent 3'-5' DNA helicase activity(GO:1990518)
0.0 0.2 GO:0000700 mismatch base pair DNA N-glycosylase activity(GO:0000700) pyrimidine-specific mismatch base pair DNA N-glycosylase activity(GO:0008263)
0.0 0.2 GO:0004096 catalase activity(GO:0004096)
0.0 0.1 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 0.1 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 0.1 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.2 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.2 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.2 REACTOME FATTY ACYL COA BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis