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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for patz1
Z-value: 1.49
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Transcription factors associated with patz1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| patz1 | dr11_v1_chr6_+_40951227_40951227 | -0.94 | 8.3e-09 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_48111285 Show fit | 5.85 |
ENSDART00000169420
|
NME/NM23 nucleoside diphosphate kinase 2b, tandem duplicate 2 |
|
| chr6_+_475264 Show fit | 5.61 |
ENSDART00000193615
|
|
|
| chr20_-_147574 Show fit | 5.12 |
ENSDART00000104762
ENSDART00000131635 |
solute carrier family 16 (aromatic amino acid transporter), member 10 |
|
| chr3_+_12554801 Show fit | 5.03 |
ENSDART00000167177
|
cyclin F |
|
| chr20_-_7080427 Show fit | 4.90 |
ENSDART00000140166
ENSDART00000023677 |
si:ch211-121a2.2 |
|
| chr6_-_42418225 Show fit | 4.64 |
ENSDART00000002501
|
inositol hexakisphosphate kinase 2a |
|
| chr21_+_11885404 Show fit | 4.29 |
ENSDART00000092015
|
DDB1 and CUL4 associated factor 12 |
|
| chr3_+_62126981 Show fit | 4.26 |
ENSDART00000060527
|
dynein regulatory complex subunit 3 |
|
| chr7_+_34688527 Show fit | 4.23 |
ENSDART00000108473
|
pleckstrin homology domain containing, family G (with RhoGef domain) member 4 |
|
| chr2_-_44183613 Show fit | 4.02 |
ENSDART00000079596
|
cell adhesion molecule 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of patz1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.6 | GO:0043066 | negative regulation of apoptotic process(GO:0043066) |
| 0.4 | 6.0 | GO:0006228 | UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051) |
| 0.1 | 5.4 | GO:0045732 | positive regulation of protein catabolic process(GO:0045732) |
| 0.6 | 5.0 | GO:0046606 | negative regulation of centrosome duplication(GO:0010826) negative regulation of centrosome cycle(GO:0046606) |
| 0.1 | 5.0 | GO:0042149 | cellular response to glucose starvation(GO:0042149) |
| 0.3 | 4.6 | GO:0045880 | positive regulation of smoothened signaling pathway(GO:0045880) |
| 0.1 | 4.4 | GO:0048010 | vascular endothelial growth factor receptor signaling pathway(GO:0048010) |
| 0.8 | 3.9 | GO:0031649 | heat generation(GO:0031649) regulation of heat generation(GO:0031650) positive regulation of heat generation(GO:0031652) regulation of phospholipid biosynthetic process(GO:0071071) negative regulation of phospholipid biosynthetic process(GO:0071072) |
| 0.3 | 3.9 | GO:0032264 | IMP salvage(GO:0032264) |
| 0.4 | 3.7 | GO:0046546 | development of primary male sexual characteristics(GO:0046546) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.9 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.3 | 5.5 | GO:0031680 | G-protein beta/gamma-subunit complex(GO:0031680) |
| 0.1 | 4.3 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.0 | 4.1 | GO:0030018 | Z disc(GO:0030018) |
| 0.2 | 3.7 | GO:0031462 | Cul2-RING ubiquitin ligase complex(GO:0031462) |
| 0.2 | 3.7 | GO:0005605 | basal lamina(GO:0005605) laminin complex(GO:0043256) |
| 0.1 | 3.4 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
| 0.0 | 3.4 | GO:0005814 | centriole(GO:0005814) |
| 0.3 | 2.9 | GO:0005832 | chaperonin-containing T-complex(GO:0005832) |
| 0.2 | 2.9 | GO:0031209 | SCAR complex(GO:0031209) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.0 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
| 0.3 | 5.5 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
| 0.1 | 5.5 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 1.3 | 5.1 | GO:0015349 | thyroid hormone transmembrane transporter activity(GO:0015349) |
| 0.3 | 4.6 | GO:0000828 | inositol hexakisphosphate kinase activity(GO:0000828) |
| 0.6 | 3.9 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 0.4 | 3.9 | GO:0047623 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
| 0.1 | 3.5 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.1 | 3.4 | GO:0046935 | 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935) |
| 0.0 | 3.3 | GO:0019901 | protein kinase binding(GO:0019901) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 4.5 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.1 | 3.4 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 3.4 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.1 | 3.1 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.1 | 2.3 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.1 | 1.8 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 1.8 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.0 | 1.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 1.7 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 1.6 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 5.5 | REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR | Genes involved in Thromboxane signalling through TP receptor |
| 0.0 | 3.4 | REACTOME SIGNALING BY ERBB4 | Genes involved in Signaling by ERBB4 |
| 0.1 | 2.9 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.2 | 2.6 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 2.5 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.2 | 2.3 | REACTOME IRAK1 RECRUITS IKK COMPLEX | Genes involved in IRAK1 recruits IKK complex |
| 0.0 | 2.3 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.1 | 2.1 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.1 | 2.1 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 1.8 | REACTOME MYOGENESIS | Genes involved in Myogenesis |