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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for pax10+pax6a+pax6b

Z-value: 1.31

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Transcription factors associated with pax10+pax6a+pax6b

Gene Symbol Gene ID Gene Info
pax6b
ENSDARG00000045936 paired box 6b
pax10
ENSDARG00000053364 paired box 10
pax6a
ENSDARG00000103379 paired box 6a
pax10
ENSDARG00000111379 paired box 10

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
pax6adr11_v1_chr25_-_15049694_15049781-0.994.5e-14Click!
pax10dr11_v1_chr3_+_32553714_32553714-0.644.3e-03Click!
pax6bdr11_v1_chr7_+_15872357_15872357-0.484.5e-02Click!

Activity profile of pax10+pax6a+pax6b motif

Sorted Z-values of pax10+pax6a+pax6b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_8046764 6.31 ENSDART00000099031
zgc:136254
zgc:136254
chr10_-_8053385 5.73 ENSDART00000142714
si:ch211-251f6.7
si:ch211-251f6.7
chr25_+_22320738 5.19 ENSDART00000073566
cyp11a1
cytochrome P450, family 11, subfamily A, polypeptide 1
chr3_+_43086548 4.99 ENSDART00000163579
si:dkey-43p13.5
si:dkey-43p13.5
chr8_+_52442622 4.82 ENSDART00000012758
zgc:77112
zgc:77112
chr10_-_8053753 4.44 ENSDART00000162289
si:ch211-251f6.7
si:ch211-251f6.7
chr8_+_52442785 4.35 ENSDART00000189958
zgc:77112
zgc:77112
chr2_+_6255434 3.28 ENSDART00000139429
zp3b
zona pellucida glycoprotein 3b
chr5_+_57924611 3.09 ENSDART00000050949
btg4
B-cell translocation gene 4
chr21_-_2322102 2.94 ENSDART00000162867
zgc:66483
zgc:66483
chr16_+_39159752 2.89 ENSDART00000122081
sybu
syntabulin (syntaxin-interacting)
chr7_-_20582842 2.81 ENSDART00000169750
ENSDART00000111719
si:dkey-19b23.11
si:dkey-19b23.11
chr9_+_23003208 2.78 ENSDART00000021060
eaf2
ELL associated factor 2
chr19_-_42503143 2.73 ENSDART00000007642
zgc:110239
zgc:110239
chr9_+_8365398 2.73 ENSDART00000138713
ENSDART00000136847
si:dkey-90l23.2
si:dkey-90l23.2
chr3_-_26184018 2.56 ENSDART00000191604
si:ch211-11k18.4
si:ch211-11k18.4
chr23_+_17926279 2.51 ENSDART00000012540
chia.4
chitinase, acidic.4
chr25_+_7532811 2.39 ENSDART00000161593
ptdss2
phosphatidylserine synthase 2
chr17_+_17804752 2.35 ENSDART00000123350
sptlc2a
serine palmitoyltransferase, long chain base subunit 2a
chr21_-_22117085 2.31 ENSDART00000146673
slc35f2
solute carrier family 35, member F2
chr13_-_32726178 2.30 ENSDART00000012232
pdss2
prenyl (decaprenyl) diphosphate synthase, subunit 2
chr19_-_11015238 2.30 ENSDART00000010997
tpm3
tropomyosin 3
chr3_-_54607166 2.24 ENSDART00000021977
dnmt1
DNA (cytosine-5-)-methyltransferase 1
chr19_-_25114701 2.11 ENSDART00000149035
ptp4a3
protein tyrosine phosphatase type IVA, member 3
chr5_-_47975440 2.11 ENSDART00000145665
ENSDART00000007057
ccnh
cyclin H
chr23_-_27235403 1.91 ENSDART00000134418
si:dkey-157g16.6
si:dkey-157g16.6
chr4_-_13613148 1.88 ENSDART00000067164
ENSDART00000111247
irf5
interferon regulatory factor 5
chr3_+_25914064 1.87 ENSDART00000162558
ENSDART00000166843
tom1
target of myb1 membrane trafficking protein
chr13_-_25196758 1.87 ENSDART00000184722
adka
adenosine kinase a
chr1_+_2431956 1.86 ENSDART00000183832
farp1
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
chr1_-_29653472 1.82 ENSDART00000109224
si:dkey-1h24.2
si:dkey-1h24.2
chr23_+_36460239 1.79 ENSDART00000172441
lima1a
LIM domain and actin binding 1a
chr6_+_33076839 1.76 ENSDART00000073755
ENSDART00000122242
pomgnt1
protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)
chr25_+_19870603 1.73 ENSDART00000047251
gramd4b
GRAM domain containing 4b
chr18_-_15269272 1.73 ENSDART00000048206
tmem263
transmembrane protein 263
chr5_+_41477954 1.72 ENSDART00000185871
pias2
protein inhibitor of activated STAT, 2
chr19_-_4793263 1.68 ENSDART00000147510
ENSDART00000141336
ENSDART00000110551
ENSDART00000146684
st3gal1
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr12_+_3571770 1.67 ENSDART00000164707
ENSDART00000189819
coa3a
cytochrome C oxidase assembly factor 3a
chr2_+_2772447 1.66 ENSDART00000124882
thoc1
THO complex 1
chr5_+_60590796 1.62 ENSDART00000159859
tmem132e
transmembrane protein 132E
chr23_-_24542156 1.61 ENSDART00000132265
atp13a2
ATPase 13A2
chr16_-_25680666 1.60 ENSDART00000132693
ENSDART00000140539
ENSDART00000015302
tomm40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr15_-_1001177 1.56 ENSDART00000160730
zgc:162936
zgc:162936
chr5_-_26247973 1.55 ENSDART00000098527
erap1b
endoplasmic reticulum aminopeptidase 1b
chr20_-_3238110 1.55 ENSDART00000008077
spint1b
serine peptidase inhibitor, Kunitz type 1 b
chr11_-_44931962 1.51 ENSDART00000170345
pfklb
phosphofructokinase, liver b
chr18_+_14277003 1.49 ENSDART00000006628
zgc:173742
zgc:173742
chr21_-_32781612 1.45 ENSDART00000031028
cnot6a
CCR4-NOT transcription complex, subunit 6a
chr2_+_25657958 1.43 ENSDART00000161407
tnika
TRAF2 and NCK interacting kinase a
chr7_+_26545911 1.43 ENSDART00000135313
tnk1
tyrosine kinase, non-receptor, 1
chr5_+_41477526 1.39 ENSDART00000153567
pias2
protein inhibitor of activated STAT, 2
chr4_-_4261673 1.38 ENSDART00000150694
cd9b
CD9 molecule b
chr12_-_48374728 1.36 ENSDART00000153403
ENSDART00000188117
dnajb12b
DnaJ (Hsp40) homolog, subfamily B, member 12b
chr12_+_23812530 1.33 ENSDART00000066331
svila
supervillin a
chr23_-_27505825 1.32 ENSDART00000137229
ENSDART00000013797
asb8
ankyrin repeat and SOCS box containing 8
chr12_+_47794089 1.31 ENSDART00000160726
polr3a
polymerase (RNA) III (DNA directed) polypeptide A
chr10_-_14920989 1.31 ENSDART00000184617
smad2
SMAD family member 2
chr15_+_39977461 1.29 ENSDART00000063786
cab39
calcium binding protein 39
chr23_-_15916316 1.29 ENSDART00000134096
ENSDART00000042469
ENSDART00000146605
mrgbp
MRG/MORF4L binding protein
chr7_-_58244220 1.29 ENSDART00000180450
unm_hu7910
un-named hu7910
chr6_-_10034145 1.29 ENSDART00000185999
nudt15
nudix (nucleoside diphosphate linked moiety X)-type motif 15
chr18_+_50924556 1.27 ENSDART00000159287
pik3c2g
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
chr2_+_11031360 1.22 ENSDART00000180020
ENSDART00000145093
acot11a
acyl-CoA thioesterase 11a
chr9_+_43797902 1.20 ENSDART00000020550
ube2e3
ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)
chr23_-_18381361 1.20 ENSDART00000016891
hsd17b10
hydroxysteroid (17-beta) dehydrogenase 10
chr24_+_11908833 1.19 ENSDART00000178622
fen1
flap structure-specific endonuclease 1
chr19_-_3726768 1.19 ENSDART00000161738
smim13
small integral membrane protein 13
chr5_-_55914268 1.18 ENSDART00000014049
wdr36
WD repeat domain 36
chr23_+_25292147 1.18 ENSDART00000131486
pa2g4b
proliferation-associated 2G4, b
chr25_+_7532627 1.18 ENSDART00000187660
ptdss2
phosphatidylserine synthase 2
chr24_-_41320037 1.16 ENSDART00000129058
rheb
Ras homolog, mTORC1 binding
chr9_-_50000144 1.14 ENSDART00000123416
scn1a
sodium channel, voltage-gated, type I, alpha
chr9_-_746317 1.14 ENSDART00000129632
ENSDART00000130720
usp37
ubiquitin specific peptidase 37
chr13_-_31164749 1.14 ENSDART00000049180
mapk8a
mitogen-activated protein kinase 8a
chr23_+_25291891 1.13 ENSDART00000016248
pa2g4b
proliferation-associated 2G4, b
chr12_-_35582683 1.12 ENSDART00000167933
sec24c
SEC24 homolog C, COPII coat complex component
chr18_-_45761868 1.10 ENSDART00000025423
cstf3
cleavage stimulation factor, 3' pre-RNA, subunit 3
chr4_+_5341592 1.10 ENSDART00000123375
ENSDART00000067371
zgc:113263
zgc:113263
chr4_-_9196291 1.10 ENSDART00000153963
hcfc2
host cell factor C2
chr24_-_2381143 1.10 ENSDART00000144307
rreb1a
ras responsive element binding protein 1a
chr23_+_44611864 1.09 ENSDART00000145905
ENSDART00000132361
eno3
enolase 3, (beta, muscle)
chr5_+_62052750 1.08 ENSDART00000192103
ENSDART00000181866
si:dkey-35m8.1
si:dkey-35m8.1
chr24_+_11908480 1.08 ENSDART00000024224
fen1
flap structure-specific endonuclease 1
chr24_+_26379441 1.08 ENSDART00000137786
si:ch211-230g15.5
si:ch211-230g15.5
chr21_-_7178348 1.05 ENSDART00000187467
fam69b
family with sequence similarity 69, member B
chr7_+_26545502 1.05 ENSDART00000140528
tnk1
tyrosine kinase, non-receptor, 1
chr3_-_34717882 1.05 ENSDART00000151127
thraa
thyroid hormone receptor alpha a
chr4_+_76466751 1.05 ENSDART00000164709
zgc:153116
zgc:153116
chr9_-_31915423 1.05 ENSDART00000060051
fgf14
fibroblast growth factor 14
chr18_-_21685055 1.04 ENSDART00000019861
mbtps1
membrane-bound transcription factor peptidase, site 1
chr14_+_24934736 1.03 ENSDART00000191821
ppargc1b
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
chr14_-_5407555 1.01 ENSDART00000001424
pcgf1
polycomb group ring finger 1
chr15_-_704408 1.00 ENSDART00000156200
ENSDART00000166404
ENSDART00000131040
zgc:174574
zgc:174574
chr3_-_23513155 0.99 ENSDART00000170200
BX682558.1

chr5_+_40837539 0.98 ENSDART00000188279
si:dkey-3h3.3
si:dkey-3h3.3
chr4_+_13931578 0.98 ENSDART00000142466
pphln1
periphilin 1
chr4_-_13931508 0.96 ENSDART00000067174
zcrb1
zinc finger CCHC-type and RNA binding motif 1
chr10_-_167782 0.95 ENSDART00000108780
erg
v-ets avian erythroblastosis virus E26 oncogene homolog
chr11_-_11336986 0.95 ENSDART00000016677
zgc:77929
zgc:77929
chr2_+_21048661 0.94 ENSDART00000156876
rreb1b
ras responsive element binding protein 1b
chr18_-_20466061 0.93 ENSDART00000060311
paqr5a
progestin and adipoQ receptor family member Va
chr23_+_44614056 0.91 ENSDART00000188379
eno3
enolase 3, (beta, muscle)
chr7_-_30624435 0.89 ENSDART00000173828
rnf111
ring finger protein 111
chr13_-_31167461 0.89 ENSDART00000190640
ENSDART00000192002
mapk8a
mitogen-activated protein kinase 8a
chr4_-_13931293 0.89 ENSDART00000067172
zcrb1
zinc finger CCHC-type and RNA binding motif 1
chr11_+_19603251 0.86 ENSDART00000005639
thoc7
THO complex 7
chr7_-_45852270 0.86 ENSDART00000170224
shcbp1
SHC SH2-domain binding protein 1
chr17_-_41798856 0.86 ENSDART00000156031
ENSDART00000192801
ENSDART00000180172
ENSDART00000084745
ENSDART00000175577
ralgapa2
Ral GTPase activating protein, alpha subunit 2 (catalytic)
chr3_+_60828813 0.85 ENSDART00000128260
CABZ01087514.1

chr8_-_28357177 0.85 ENSDART00000182319
KLHL12 (1 of many)
kelch like family member 12
chr20_+_27712714 0.84 ENSDART00000008306
zbtb1
zinc finger and BTB domain containing 1
chr10_+_24690534 0.84 ENSDART00000079549
tpte
transmembrane phosphatase with tensin homology
chr23_+_30707837 0.83 ENSDART00000016096
dnajc11a
DnaJ (Hsp40) homolog, subfamily C, member 11a
chr15_+_1534644 0.83 ENSDART00000130413
smc4
structural maintenance of chromosomes 4
chr14_-_14659023 0.82 ENSDART00000170355
ENSDART00000159888
ENSDART00000172241
nsdhl
NAD(P) dependent steroid dehydrogenase-like
chr5_-_33039670 0.82 ENSDART00000141361
glipr2
GLI pathogenesis-related 2
chr25_-_10791437 0.81 ENSDART00000127054
BX572619.1

chr14_-_45967981 0.80 ENSDART00000188062
macrod1
MACRO domain containing 1
chr5_+_38825225 0.80 ENSDART00000076835
mrpl1
mitochondrial ribosomal protein L1
chr13_-_11378127 0.79 ENSDART00000158632
akt3a
v-akt murine thymoma viral oncogene homolog 3a
chr16_-_5105295 0.79 ENSDART00000082071
ENSDART00000148955
ENSDART00000184700
ENSDART00000188127
bckdhb
branched chain keto acid dehydrogenase E1, beta polypeptide
chr17_-_15029258 0.78 ENSDART00000168332
ENSDART00000012877
ENSDART00000109190
ero1a
endoplasmic reticulum oxidoreductase alpha
chr21_-_17016788 0.78 ENSDART00000186703
AL844518.1

chr23_-_7125494 0.78 ENSDART00000111929
slco4a1
solute carrier organic anion transporter family, member 4A1
chr17_+_43926523 0.77 ENSDART00000121550
ENSDART00000041447
ktn1
kinectin 1
chr12_+_33361948 0.77 ENSDART00000124982
fasn
fatty acid synthase
chr24_+_37709191 0.76 ENSDART00000066558
decr2
2,4-dienoyl CoA reductase 2, peroxisomal
chr11_+_45153104 0.75 ENSDART00000159204
ENSDART00000177585
tk1
thymidine kinase 1, soluble
chr23_-_2901167 0.75 ENSDART00000165955
ENSDART00000190616
zhx3
zinc fingers and homeoboxes 3
chr7_-_19526721 0.74 ENSDART00000114203
man2b2
mannosidase, alpha, class 2B, member 2
chr25_-_37284370 0.73 ENSDART00000103222
nudt7
nudix (nucleoside diphosphate linked moiety X)-type motif 7
chr3_-_37351225 0.73 ENSDART00000174685
si:ch211-278a6.1
si:ch211-278a6.1
chr22_+_21398508 0.72 ENSDART00000089408
ENSDART00000186091
shdb
Src homology 2 domain containing transforming protein D, b
chr14_+_22172047 0.72 ENSDART00000114750
ENSDART00000148259
gabrb2
gamma-aminobutyric acid (GABA) A receptor, beta 2
chr7_-_73843720 0.72 ENSDART00000111622
caap1
caspase activity and apoptosis inhibitor 1
chr2_-_48753873 0.72 ENSDART00000189556
CABZ01044731.1

chr12_-_35582521 0.71 ENSDART00000162175
ENSDART00000168958
sec24c
SEC24 homolog C, COPII coat complex component
chr11_-_4023940 0.71 ENSDART00000058728
ENSDART00000171245
nek4
NIMA-related kinase 4
chr19_+_12413683 0.71 ENSDART00000151214
seh1l
SEH1-like (S. cerevisiae)
chr4_-_1818315 0.71 ENSDART00000067433
ube2nb
ubiquitin-conjugating enzyme E2Nb
chr2_+_21000334 0.71 ENSDART00000062563
ENSDART00000147809
rreb1b
ras responsive element binding protein 1b
chr5_+_4054704 0.70 ENSDART00000140537
dhrs11a
dehydrogenase/reductase (SDR family) member 11a
chr20_+_4334008 0.69 ENSDART00000168322
tiam2b
T cell lymphoma invasion and metastasis 2b
chr7_-_30174882 0.68 ENSDART00000110409
frmd5
FERM domain containing 5
chr5_+_32162684 0.67 ENSDART00000134472
taok3b
TAO kinase 3b
chr12_-_3077395 0.67 ENSDART00000002867
ENSDART00000126315
rfng
RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr9_+_31222026 0.67 ENSDART00000145573
clybl
citrate lyase beta like
chr2_+_40294313 0.66 ENSDART00000037292
epha4b
eph receptor A4b
chr1_+_11107688 0.66 ENSDART00000109858
knstrn
kinetochore-localized astrin/SPAG5 binding protein
chr23_-_40194732 0.66 ENSDART00000164931
tgm1l2
transglutaminase 1 like 2
chr8_-_44223899 0.64 ENSDART00000143020
stx2b
syntaxin 2b
chr25_+_5015019 0.64 ENSDART00000127600
hdac10
histone deacetylase 10
chr24_+_28383278 0.64 ENSDART00000018095
sh3glb1a
SH3-domain GRB2-like endophilin B1a
chr18_+_38775277 0.63 ENSDART00000186129
fam214a
family with sequence similarity 214, member A
chr14_+_6963312 0.62 ENSDART00000150050
hnrnpaba
heterogeneous nuclear ribonucleoprotein A/Ba
chr17_+_8799661 0.62 ENSDART00000105326
tonsl
tonsoku-like, DNA repair protein
chr22_+_18389271 0.61 ENSDART00000088270
yjefn3
YjeF N-terminal domain containing 3
chr14_+_29609245 0.59 ENSDART00000043058
TENM2
si:dkey-34l15.2
chr13_-_48388726 0.59 ENSDART00000169473
fbxo11a
F-box protein 11a
chr8_-_44223473 0.59 ENSDART00000098525
stx2b
syntaxin 2b
chr4_+_13931733 0.58 ENSDART00000141742
ENSDART00000067175
pphln1
periphilin 1
chr15_-_43238220 0.58 ENSDART00000027019
wdfy1
WD repeat and FYVE domain containing 1
chr8_-_8489685 0.58 ENSDART00000131849
ENSDART00000064113
abt1
activator of basal transcription 1
chr15_+_19990068 0.57 ENSDART00000154033
ENSDART00000054428
zgc:112083
zgc:112083
chr1_-_26045560 0.57 ENSDART00000172737
ENSDART00000076120
ENSDART00000193593
gpank1
G patch domain and ankyrin repeats 1
chr5_+_32490238 0.56 ENSDART00000191839
ndor1
NADPH dependent diflavin oxidoreductase 1
chr22_-_3182965 0.56 ENSDART00000158009
lonp1
lon peptidase 1, mitochondrial
chr7_-_17814118 0.56 ENSDART00000179688
ecsit
ECSIT signalling integrator
chr21_-_3700334 0.55 ENSDART00000137844
atp8b1
ATPase phospholipid transporting 8B1
chr9_-_53537989 0.54 ENSDART00000114022
slitrk5b
SLIT and NTRK-like family, member 5b
chr3_-_50139860 0.53 ENSDART00000101563
btr02
bloodthirsty-related gene family, member 2
chr25_+_4635355 0.53 ENSDART00000021120
pgghg
protein-glucosylgalactosylhydroxylysine glucosidase
chr11_-_3897067 0.52 ENSDART00000134858
rpn1
ribophorin I
chr17_+_8799451 0.52 ENSDART00000189814
ENSDART00000191577
tonsl
tonsoku-like, DNA repair protein
chr18_+_45542981 0.52 ENSDART00000140357
kifc3
kinesin family member C3
chr22_+_22438783 0.52 ENSDART00000147825
kif14
kinesin family member 14
chr16_+_48460873 0.51 ENSDART00000159902
ext1a
exostosin glycosyltransferase 1a
chr24_+_28561038 0.50 ENSDART00000147063
abca4a
ATP-binding cassette, sub-family A (ABC1), member 4a
chr18_-_16315822 0.50 ENSDART00000136479
rassf9
Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
chr14_+_31529958 0.49 ENSDART00000053026
fam122b
family with sequence similarity 122B
chr8_-_8489886 0.49 ENSDART00000183334
abt1
activator of basal transcription 1
chr18_+_36782930 0.48 ENSDART00000004129
si:ch211-160d20.3
si:ch211-160d20.3
chr23_-_33680265 0.48 ENSDART00000138416
tfcp2
transcription factor CP2
chr4_-_5370468 0.48 ENSDART00000133423
ENSDART00000184963
si:dkey-14d8.1
si:dkey-14d8.1
chr23_+_38957738 0.47 ENSDART00000193480
ATP9A
ATPase phospholipid transporting 9A (putative)
chr14_-_7375049 0.47 ENSDART00000054809
trappc11
trafficking protein particle complex 11
chr10_+_37500234 0.47 ENSDART00000132096
ENSDART00000099473
msi2a
musashi RNA-binding protein 2a
chr13_+_21919786 0.46 ENSDART00000182440
ndst2a
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2a
chr16_+_21918503 0.45 ENSDART00000167919
znf687a
zinc finger protein 687a
chr11_+_2902592 0.45 ENSDART00000093108
kif21b
kinesin family member 21B
chr13_-_4018888 0.45 ENSDART00000058238
tjap1
tight junction associated protein 1 (peripheral)
chr12_-_4408828 0.45 ENSDART00000152447
si:ch211-173d10.1
si:ch211-173d10.1
chr3_-_36152974 0.45 ENSDART00000002568
engase
endo-beta-N-acetylglucosaminidase
chr14_+_7902374 0.44 ENSDART00000113299
zgc:110843
zgc:110843
chr18_-_14901437 0.44 ENSDART00000145842
ENSDART00000008035
trabd
TraB domain containing
chr17_-_27266053 0.44 ENSDART00000110903
E2F2
si:ch211-160f23.5
chr7_-_30544702 0.44 ENSDART00000182409
sltm
SAFB-like, transcription modulator
chr8_+_25892319 0.43 ENSDART00000187167
ENSDART00000078163
tmem115
transmembrane protein 115
chr7_+_38750871 0.43 ENSDART00000114238
ENSDART00000052325
ENSDART00000137001
f2
coagulation factor II (thrombin)
chr22_+_11144153 0.42 ENSDART00000047442
bcor
BCL6 corepressor

Network of associatons between targets according to the STRING database.

First level regulatory network of pax10+pax6a+pax6b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 5.2 GO:0006700 C21-steroid hormone biosynthetic process(GO:0006700)
0.7 2.9 GO:0060074 synapse maturation(GO:0060074)
0.4 2.2 GO:0032776 DNA methylation on cytosine(GO:0032776)
0.4 1.7 GO:0034164 regulation of toll-like receptor 9 signaling pathway(GO:0034163) negative regulation of toll-like receptor 9 signaling pathway(GO:0034164)
0.4 1.7 GO:0070131 regulation of mitochondrial translation(GO:0070129) positive regulation of mitochondrial translation(GO:0070131)
0.4 9.2 GO:0005979 regulation of glycogen biosynthetic process(GO:0005979) regulation of glucan biosynthetic process(GO:0010962)
0.4 2.3 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.4 3.6 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.4 1.1 GO:0000967 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000472) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480) rRNA 5'-end processing(GO:0000967) ncRNA 5'-end processing(GO:0034471)
0.3 1.9 GO:0044209 AMP salvage(GO:0044209)
0.3 1.6 GO:0097355 protein localization to heterochromatin(GO:0097355)
0.3 1.3 GO:0042264 peptidyl-aspartic acid modification(GO:0018197) peptidyl-aspartic acid hydroxylation(GO:0042264)
0.3 1.8 GO:0016266 O-glycan processing(GO:0016266)
0.2 2.0 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889)
0.2 0.7 GO:0009120 deoxyribonucleoside metabolic process(GO:0009120) thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
0.2 2.5 GO:0006032 chitin catabolic process(GO:0006032)
0.2 1.3 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.2 2.4 GO:0034312 diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512)
0.2 1.6 GO:0021588 cerebellum formation(GO:0021588)
0.2 3.3 GO:0060046 binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.2 1.3 GO:0009146 dGTP catabolic process(GO:0006203) purine nucleoside triphosphate catabolic process(GO:0009146) purine deoxyribonucleoside triphosphate catabolic process(GO:0009217) dGTP metabolic process(GO:0046070)
0.2 0.6 GO:0010874 regulation of cholesterol efflux(GO:0010874)
0.1 0.9 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.1 2.2 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.1 1.5 GO:0019883 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous antigen(GO:0019883) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.1 0.7 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.1 0.8 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.1 2.8 GO:0014812 muscle cell migration(GO:0014812)
0.1 1.1 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.1 0.7 GO:0006013 mannose metabolic process(GO:0006013)
0.1 1.8 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.1 0.7 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.1 2.3 GO:0006743 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.1 0.3 GO:0002188 translation reinitiation(GO:0002188)
0.1 3.1 GO:0016925 protein sumoylation(GO:0016925)
0.1 1.2 GO:0035677 posterior lateral line neuromast hair cell development(GO:0035677)
0.1 1.1 GO:0002154 thyroid hormone mediated signaling pathway(GO:0002154)
0.1 0.7 GO:0051315 attachment of mitotic spindle microtubules to kinetochore(GO:0051315)
0.1 1.1 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.1 0.7 GO:0070571 negative regulation of axon regeneration(GO:0048681) negative regulation of neuron projection regeneration(GO:0070571)
0.1 1.1 GO:1904356 regulation of telomere maintenance via telomere lengthening(GO:1904356)
0.1 1.6 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 1.5 GO:0006265 DNA topological change(GO:0006265)
0.1 0.3 GO:1905048 regulation of metallopeptidase activity(GO:1905048)
0.1 1.0 GO:0060217 hemangioblast cell differentiation(GO:0060217)
0.1 0.9 GO:0061615 glucose catabolic process(GO:0006007) NADH regeneration(GO:0006735) glycolytic process through fructose-6-phosphate(GO:0061615) glycolytic process through glucose-6-phosphate(GO:0061620) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.1 0.7 GO:0009109 coenzyme catabolic process(GO:0009109)
0.1 0.3 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.1 0.6 GO:0061635 regulation of protein complex stability(GO:0061635)
0.1 1.2 GO:0007340 acrosome reaction(GO:0007340)
0.1 0.2 GO:0010847 regulation of chromatin assembly(GO:0010847)
0.1 1.0 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.1 1.5 GO:0071218 response to misfolded protein(GO:0051788) cellular response to misfolded protein(GO:0071218)
0.1 1.0 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.1 0.4 GO:0006953 acute-phase response(GO:0006953)
0.1 2.5 GO:0071427 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.1 1.3 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.1 0.8 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.1 0.4 GO:0006517 protein deglycosylation(GO:0006517)
0.1 4.1 GO:0048484 enteric nervous system development(GO:0048484)
0.1 0.6 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.1 0.7 GO:0035284 central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.1 2.2 GO:0014866 skeletal myofibril assembly(GO:0014866)
0.1 0.8 GO:0042407 cristae formation(GO:0042407)
0.1 1.1 GO:0031297 replication fork processing(GO:0031297)
0.1 0.4 GO:0098937 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937) anterograde dendritic transport of neurotransmitter receptor complex(GO:0098971)
0.1 0.1 GO:0010934 macrophage cytokine production(GO:0010934) regulation of macrophage cytokine production(GO:0010935) positive regulation of macrophage cytokine production(GO:0060907)
0.1 0.8 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.1 1.9 GO:0003094 glomerular filtration(GO:0003094)
0.0 0.7 GO:0061001 regulation of dendritic spine morphogenesis(GO:0061001)
0.0 0.7 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.0 1.2 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.0 0.3 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.0 0.6 GO:0018279 peptidyl-asparagine modification(GO:0018196) protein N-linked glycosylation via asparagine(GO:0018279)
0.0 1.4 GO:0007338 single fertilization(GO:0007338)
0.0 1.3 GO:0051014 actin filament severing(GO:0051014)
0.0 0.5 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 1.5 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.8 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.1 GO:0032290 peripheral nervous system myelin formation(GO:0032290) semicircular canal fusion(GO:0060879)
0.0 0.5 GO:0016233 telomere capping(GO:0016233)
0.0 0.3 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.0 0.4 GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902254)
0.0 0.1 GO:0060829 negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060829)
0.0 0.2 GO:0016180 snRNA processing(GO:0016180)
0.0 0.4 GO:0006797 polyphosphate metabolic process(GO:0006797) polyphosphate catabolic process(GO:0006798)
0.0 0.3 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.0 0.7 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.6 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 3.2 GO:0031098 stress-activated protein kinase signaling cascade(GO:0031098)
0.0 0.1 GO:0006500 N-terminal protein palmitoylation(GO:0006500) negative regulation of lipoprotein metabolic process(GO:0050748) regulation of N-terminal protein palmitoylation(GO:0060254) negative regulation of N-terminal protein palmitoylation(GO:0060262) negative regulation of protein lipidation(GO:1903060)
0.0 0.5 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 2.8 GO:0008285 negative regulation of cell proliferation(GO:0008285)
0.0 2.0 GO:0007030 Golgi organization(GO:0007030)
0.0 0.8 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.0 0.8 GO:0001878 response to yeast(GO:0001878)
0.0 0.2 GO:0097531 mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0 0.1 GO:0045337 farnesyl diphosphate biosynthetic process(GO:0045337)
0.0 0.2 GO:0036060 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.0 0.5 GO:0015012 heparan sulfate proteoglycan biosynthetic process(GO:0015012)
0.0 1.0 GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity(GO:0051091)
0.0 1.0 GO:0051607 defense response to virus(GO:0051607)
0.0 0.1 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.0 0.4 GO:0006513 protein monoubiquitination(GO:0006513)
0.0 0.1 GO:0090243 fibroblast growth factor receptor signaling pathway involved in somitogenesis(GO:0090243)
0.0 0.9 GO:0048477 oogenesis(GO:0048477)
0.0 0.1 GO:0019441 tryptophan catabolic process to kynurenine(GO:0019441) 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.0 1.1 GO:0031123 RNA 3'-end processing(GO:0031123)
0.0 0.6 GO:0035825 reciprocal DNA recombination(GO:0035825)
0.0 0.3 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 0.3 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.0 0.4 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 2.8 GO:0016197 endosomal transport(GO:0016197)
0.0 1.2 GO:0006637 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 9.2 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.4 16.5 GO:0000421 autophagosome membrane(GO:0000421)
0.4 2.5 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.3 2.8 GO:0032783 ELL-EAF complex(GO:0032783)
0.3 0.8 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.2 2.0 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.2 2.4 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.2 2.1 GO:0005675 holo TFIIH complex(GO:0005675)
0.2 1.2 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.2 1.1 GO:0005662 DNA replication factor A complex(GO:0005662)
0.1 1.6 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 0.3 GO:0005960 glycine cleavage complex(GO:0005960)
0.1 1.6 GO:0070187 telosome(GO:0070187)
0.1 0.7 GO:0031371 ubiquitin conjugating enzyme complex(GO:0031371)
0.1 1.8 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 2.1 GO:0035102 PRC1 complex(GO:0035102)
0.1 0.9 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.1 1.8 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.1 0.8 GO:0061617 MICOS complex(GO:0061617)
0.1 0.2 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.1 0.7 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 1.3 GO:0035267 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.1 2.7 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 0.3 GO:1990909 Wnt signalosome(GO:1990909)
0.1 1.3 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.1 0.7 GO:0034451 centriolar satellite(GO:0034451)
0.1 1.1 GO:0044665 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.1 0.3 GO:0055087 Ski complex(GO:0055087)
0.1 1.3 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.1 0.3 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.2 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 0.2 GO:0033165 interphotoreceptor matrix(GO:0033165)
0.0 0.6 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.9 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 1.7 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.9 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 2.4 GO:0030173 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.0 0.9 GO:0016605 PML body(GO:0016605)
0.0 1.3 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 2.4 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 0.5 GO:0005844 polysome(GO:0005844)
0.0 4.5 GO:0005730 nucleolus(GO:0005730)
0.0 1.7 GO:0005884 actin filament(GO:0005884)
0.0 0.1 GO:0089701 U2AF(GO:0089701)
0.0 1.1 GO:0005871 kinesin complex(GO:0005871)
0.0 0.1 GO:0032806 carboxy-terminal domain protein kinase complex(GO:0032806)
0.0 3.1 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 1.5 GO:0043296 apical junction complex(GO:0043296)
0.0 0.4 GO:0030134 ER to Golgi transport vesicle(GO:0030134)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.2 GO:0016713 cholesterol monooxygenase (side-chain-cleaving) activity(GO:0008386) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen(GO:0016713)
0.6 9.2 GO:2001069 glycogen binding(GO:2001069)
0.5 16.5 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.5 2.8 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.4 1.9 GO:0004001 adenosine kinase activity(GO:0004001)
0.3 2.4 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.3 2.3 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.3 1.3 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.3 3.3 GO:0035804 structural constituent of egg coat(GO:0035804)
0.3 0.9 GO:0032184 SUMO polymer binding(GO:0032184)
0.2 2.0 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.2 3.1 GO:0061665 SUMO ligase activity(GO:0061665)
0.2 2.5 GO:0004568 chitinase activity(GO:0004568)
0.2 0.7 GO:0047777 (3S)-citramalyl-CoA lyase activity(GO:0047777)
0.2 1.3 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.2 1.7 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.2 2.0 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.2 1.2 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.2 2.2 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.2 1.0 GO:0030331 estrogen receptor binding(GO:0030331)
0.2 0.7 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.2 3.7 GO:0019894 kinesin binding(GO:0019894)
0.2 0.6 GO:0047611 acetylspermidine deacetylase activity(GO:0047611)
0.1 0.6 GO:0003958 NADPH-hemoprotein reductase activity(GO:0003958)
0.1 0.8 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.1 0.5 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.1 0.7 GO:0001784 phosphotyrosine binding(GO:0001784)
0.1 1.5 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.1 0.7 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.1 1.6 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.1 1.5 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 2.4 GO:0004659 prenyltransferase activity(GO:0004659)
0.1 0.8 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.1 1.4 GO:0030544 Hsp70 protein binding(GO:0030544)
0.1 0.9 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.1 1.3 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.1 1.3 GO:0070411 I-SMAD binding(GO:0070411)
0.1 0.6 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.1 0.8 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.1 0.5 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.1 0.3 GO:0033192 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 1.5 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 1.3 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.0 0.7 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.0 0.2 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.0 2.1 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 1.3 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 1.9 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.7 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.8 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 1.0 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.7 GO:0016289 CoA hydrolase activity(GO:0016289)
0.0 0.1 GO:0004061 arylformamidase activity(GO:0004061)
0.0 1.7 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.4 GO:0004309 exopolyphosphatase activity(GO:0004309)
0.0 1.1 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 0.2 GO:0001642 group III metabotropic glutamate receptor activity(GO:0001642)
0.0 0.7 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 1.2 GO:0019003 GDP binding(GO:0019003)
0.0 1.3 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 2.1 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 1.9 GO:0030276 clathrin binding(GO:0030276)
0.0 0.3 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.0 0.6 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 3.7 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.5 GO:0015926 glucosidase activity(GO:0015926)
0.0 0.2 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 1.5 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.0 3.2 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.3 GO:0070739 protein-glutamic acid ligase activity(GO:0070739) tubulin-glutamic acid ligase activity(GO:0070740)
0.0 1.3 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.3 GO:0072542 phosphatase activator activity(GO:0019211) protein phosphatase activator activity(GO:0072542)
0.0 0.3 GO:0016854 racemase and epimerase activity(GO:0016854)
0.0 0.3 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.4 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.1 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.0 0.2 GO:0004955 prostaglandin receptor activity(GO:0004955)
0.0 0.3 GO:0004812 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.0 0.1 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.0 0.4 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.1 GO:0030332 cyclin binding(GO:0030332)
0.0 2.2 GO:0042393 histone binding(GO:0042393)
0.0 0.3 GO:0004806 triglyceride lipase activity(GO:0004806)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.1 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.1 1.3 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 2.0 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.1 0.4 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 1.9 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.4 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 1.1 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 0.3 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.9 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 1.9 PID CMYB PATHWAY C-MYB transcription factor network
0.0 1.3 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.6 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 1.0 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 1.0 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 0.8 PID AURORA B PATHWAY Aurora B signaling
0.0 1.1 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 0.8 PID P73PATHWAY p73 transcription factor network
0.0 1.9 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.9 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 0.7 PID E2F PATHWAY E2F transcription factor network
0.0 0.5 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.5 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 0.1 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 1.8 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 5.2 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.3 2.3 REACTOME EARLY PHASE OF HIV LIFE CYCLE Genes involved in Early Phase of HIV Life Cycle
0.2 1.2 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.2 1.7 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.2 1.3 REACTOME ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK Genes involved in Energy dependent regulation of mTOR by LKB1-AMPK
0.1 1.3 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.1 2.1 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 2.0 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 2.3 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 1.8 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 0.8 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.1 2.0 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 1.0 REACTOME ACTIVATION OF CHAPERONES BY ATF6 ALPHA Genes involved in Activation of Chaperones by ATF6-alpha
0.1 1.0 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 1.9 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.1 1.3 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.1 0.9 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.1 0.4 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 1.1 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 0.7 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.7 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.5 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 1.6 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.1 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.4 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 1.9 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 0.6 REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.0 0.6 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.2 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 0.2 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.5 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.3 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 1.0 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.0 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.1 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 2.1 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation