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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for pax2b
Z-value: 2.00
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Transcription factors associated with pax2b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| pax2b | dr11_v1_chr12_-_45876387_45876387 | -0.84 | 1.2e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of pax2b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.4 | GO:0043484 | regulation of RNA splicing(GO:0043484) |
| 0.4 | 8.3 | GO:0032885 | regulation of polysaccharide biosynthetic process(GO:0032885) |
| 0.1 | 7.6 | GO:0030837 | negative regulation of actin filament polymerization(GO:0030837) negative regulation of protein polymerization(GO:0032272) |
| 0.1 | 7.0 | GO:0046856 | phosphatidylinositol dephosphorylation(GO:0046856) |
| 0.3 | 6.1 | GO:0019367 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
| 0.2 | 5.8 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 1.8 | 5.4 | GO:0005981 | regulation of glycogen catabolic process(GO:0005981) |
| 1.3 | 5.4 | GO:0034969 | histone arginine methylation(GO:0034969) |
| 0.1 | 5.2 | GO:0005977 | glycogen metabolic process(GO:0005977) cellular glucan metabolic process(GO:0006073) glucan metabolic process(GO:0044042) |
| 1.6 | 4.8 | GO:0046104 | deoxyribonucleoside metabolic process(GO:0009120) thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 15.1 | GO:0043296 | apical junction complex(GO:0043296) |
| 0.1 | 13.0 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.7 | 12.5 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.0 | 9.8 | GO:0005794 | Golgi apparatus(GO:0005794) |
| 0.0 | 9.4 | GO:0005912 | adherens junction(GO:0005912) |
| 0.1 | 5.5 | GO:0005902 | microvillus(GO:0005902) |
| 0.2 | 5.3 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.0 | 5.3 | GO:0000775 | chromosome, centromeric region(GO:0000775) |
| 0.1 | 4.7 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.0 | 4.7 | GO:0016607 | nuclear speck(GO:0016607) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 13.1 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.8 | 12.5 | GO:2001069 | glycogen binding(GO:2001069) |
| 0.1 | 11.2 | GO:0050839 | cell adhesion molecule binding(GO:0050839) |
| 1.0 | 7.1 | GO:0019136 | deoxynucleoside kinase activity(GO:0019136) |
| 0.6 | 6.8 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
| 0.1 | 6.7 | GO:0017022 | myosin binding(GO:0017022) |
| 0.0 | 6.3 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.1 | 6.2 | GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712) |
| 0.3 | 6.1 | GO:0102337 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 0.0 | 6.0 | GO:0030246 | carbohydrate binding(GO:0030246) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.8 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 8.8 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 7.1 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 4.2 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.1 | 3.9 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.1 | 3.7 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 3.5 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 2.8 | PID TRAIL PATHWAY | TRAIL signaling pathway |
| 0.0 | 2.4 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.2 | 2.3 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 6.8 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.3 | 6.8 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.1 | 4.7 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.3 | 4.5 | REACTOME POL SWITCHING | Genes involved in Polymerase switching |
| 0.1 | 4.1 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.2 | 3.7 | REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
| 0.2 | 3.6 | REACTOME SPRY REGULATION OF FGF SIGNALING | Genes involved in Spry regulation of FGF signaling |
| 0.1 | 3.6 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.3 | 3.5 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.2 | 3.4 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |