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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for pax7a+pax7b+prop1

Z-value: 0.54

Motif logo

Transcription factors associated with pax7a+pax7b+prop1

Gene Symbol Gene ID Gene Info
ENSDARG00000039756 PROP paired-like homeobox 1
ENSDARG00000070818 paired box 7b
ENSDARG00000100398 paired box 7a
ENSDARG00000109950 PROP paired-like homeobox 1
ENSDARG00000111233 paired box 7a
ENSDARG00000114449 PROP paired-like homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
pax7adr11_v1_chr11_+_41242644_41242644-0.551.7e-02Click!
prop1dr11_v1_chr13_+_8677166_8677304-0.494.0e-02Click!
pax7bdr11_v1_chr23_+_20863145_20863145-0.194.6e-01Click!

Activity profile of pax7a+pax7b+prop1 motif

Sorted Z-values of pax7a+pax7b+prop1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_6253246 1.39 ENSDART00000058256
ENSDART00000076700
zona pellucida glycoprotein 3b
chr20_+_48116476 1.29 ENSDART00000043938
translocation associated membrane protein 2
chr20_+_54304800 1.16 ENSDART00000121661
zona pellucida glycoprotein 2, tandem duplicate 6
chr10_+_15255198 1.13 ENSDART00000139047
ENSDART00000172107
ENSDART00000183413
ENSDART00000185314
very low density lipoprotein receptor
chr9_+_8396755 1.03 ENSDART00000043067
zgc:171776
chr9_+_8390737 0.99 ENSDART00000190891
ENSDART00000176877
ENSDART00000144851
ENSDART00000133880
ENSDART00000142233
zgc:113984
chr24_-_38110779 0.96 ENSDART00000147783
c-reactive protein, pentraxin-related
chr15_+_34934568 0.90 ENSDART00000165210
zgc:66024
chr22_+_11972786 0.81 ENSDART00000105788
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
chr10_-_34002185 0.72 ENSDART00000046599
zygote arrest 1-like
chr21_+_31150438 0.72 ENSDART00000065366
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr14_-_14659023 0.68 ENSDART00000170355
ENSDART00000159888
ENSDART00000172241
NAD(P) dependent steroid dehydrogenase-like
chr15_-_46779934 0.65 ENSDART00000085136
chloride channel 2c
chr2_+_8112449 0.61 ENSDART00000138136
carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2a
chr23_-_14766902 0.61 ENSDART00000168113
glutathione synthetase
chr8_+_45334255 0.60 ENSDART00000126848
ENSDART00000134161
ENSDART00000142322
ENSDART00000145011
ENSDART00000183560
poly(A) binding protein, cytoplasmic 1-like
chr15_+_34592215 0.57 ENSDART00000099776
tetraspanin 13a
chr5_-_68333081 0.57 ENSDART00000168786
linker histone H1M
chr13_-_8692860 0.56 ENSDART00000058107
multiple coagulation factor deficiency 2
chr10_-_34916208 0.55 ENSDART00000187371
cyclin A1
chr21_-_2209714 0.53 ENSDART00000163659
zgc:162971
chr12_-_48188928 0.51 ENSDART00000184384
phosphatase domain containing, paladin 1a
chr12_-_33357655 0.51 ENSDART00000066233
ENSDART00000148165
solute carrier family 16 (monocarboxylate transporter), member 3
chr21_+_31150773 0.50 ENSDART00000126205
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr6_-_15491579 0.49 ENSDART00000156439
ST6 beta-galactosamide alpha-2,6-sialyltranferase 2b
chr17_-_4245902 0.49 ENSDART00000151851
growth differentiation factor 3
chr5_-_3927692 0.49 ENSDART00000146840
ENSDART00000058346
complement component 1, q subcomponent binding protein
chr24_-_11908115 0.47 ENSDART00000184329
transmembrane 9 superfamily member 1
chr19_+_19976990 0.46 ENSDART00000052627
neuropeptide VF precursor
chr12_+_22580579 0.45 ENSDART00000171725
ENSDART00000192290
capping protein (actin filament), gelsolin-like b
chr25_-_37314700 0.45 ENSDART00000017807
immunoglobulin light 4 variable 8
chr6_+_21001264 0.45 ENSDART00000044519
ENSDART00000151278
connexin 44.2
chr19_+_45962016 0.44 ENSDART00000169710
UTP23, small subunit (SSU) processome component, homolog (yeast)
chr10_-_45058886 0.44 ENSDART00000159347
mitochondrial ribosomal protein S24
chr25_+_36292057 0.44 ENSDART00000152329
brambleberry
chr20_+_54274431 0.44 ENSDART00000099338
ARP10 actin related protein 10 homolog
chr13_-_38039871 0.43 ENSDART00000140645

chr25_-_27621268 0.43 ENSDART00000146205
ENSDART00000073511
hyaluronoglucosaminidase 6
chr6_-_15492030 0.43 ENSDART00000156141
ENSDART00000183992
ST6 beta-galactosamide alpha-2,6-sialyltranferase 2b
chr5_+_37903790 0.43 ENSDART00000162470
transmembrane protease, serine 4b
chr17_-_40956035 0.42 ENSDART00000124715
si:dkey-16j16.4
chr16_+_47207691 0.42 ENSDART00000062507
islet cell autoantigen 1
chr19_-_26923273 0.41 ENSDART00000089609
SKI2 homolog, superkiller viralicidic activity 2-like
chr22_-_26865361 0.41 ENSDART00000182504
heme oxygenase 2a
chr2_+_8780443 0.41 ENSDART00000137768
zinc finger, ZZ-type containing 3
chr4_-_23759192 0.41 ENSDART00000014685
ENSDART00000131690
carboxypeptidase M
chr17_+_51682429 0.41 ENSDART00000004379
nucleolar protein 10
chr8_+_21159122 0.40 ENSDART00000033491
SPRY domain containing 4
chr17_-_13007484 0.40 ENSDART00000156812
si:dkeyp-33b5.4
chr21_-_39177564 0.40 ENSDART00000065143
unc-119 homolog b (C. elegans)
chr20_-_37813863 0.40 ENSDART00000147529
basic leucine zipper transcription factor, ATF-like 3
chr7_+_9873750 0.39 ENSDART00000173348
ENSDART00000172813
lines homolog 1
chr15_+_29727799 0.39 ENSDART00000182006
zgc:153372
chr22_-_19102256 0.38 ENSDART00000171866
ENSDART00000166295
polymerase (RNA) mitochondrial (DNA directed)
chr16_-_41646164 0.38 ENSDART00000184257
ATPase secretory pathway Ca2+ transporting 1
chr17_+_24821627 0.38 ENSDART00000112389
WD repeat domain 43
chr11_+_17984354 0.37 ENSDART00000179986
RNA pseudouridylate synthase domain containing 4
chr1_-_56948694 0.37 ENSDART00000152597
si:ch211-1f22.1
chr11_-_41220794 0.37 ENSDART00000192895
mitochondrial ribosomal protein S16
chr4_+_4849789 0.37 ENSDART00000130818
ENSDART00000127751
protein tyrosine phosphatase, receptor-type, Z polypeptide 1b
chr2_-_9818640 0.36 ENSDART00000139499
ENSDART00000165548
ENSDART00000012442
ENSDART00000046587
adaptor-related protein complex 2, mu 1 subunit, b
chr9_+_54039006 0.36 ENSDART00000112441
toll-like receptor 7
chr13_-_9841806 0.36 ENSDART00000101949
sideroflexin 4
chr7_+_51774502 0.35 ENSDART00000007767
glutamic-oxaloacetic transaminase 2b, mitochondrial
chr18_-_26715655 0.35 ENSDART00000181497
MALT paracaspase 3
chr21_+_15592426 0.35 ENSDART00000138207
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1b
chr2_-_42173834 0.35 ENSDART00000098357
ENSDART00000144707
solute carrier family 39 (zinc transporter), member 6
chr17_+_12942634 0.35 ENSDART00000016597
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b
chr23_-_19225709 0.35 ENSDART00000080099
O-acyl-ADP-ribose deacylase 1
chr4_-_77218637 0.34 ENSDART00000174325
proteasome subunit beta 10
chr9_-_43644261 0.34 ENSDART00000023684
CWC22 spliceosome-associated protein homolog (S. cerevisiae)
chr8_+_3426522 0.33 ENSDART00000159466

chr25_+_22320738 0.33 ENSDART00000073566
cytochrome P450, family 11, subfamily A, polypeptide 1
chr11_+_17984167 0.32 ENSDART00000020283
ENSDART00000188329
RNA pseudouridylate synthase domain containing 4
chr5_-_20491198 0.32 ENSDART00000183051
ENSDART00000144232
FIC domain containing
chr15_-_2519640 0.32 ENSDART00000047013
signal recognition particle receptor, B subunit
chr9_-_50000144 0.31 ENSDART00000123416
sodium channel, voltage-gated, type I, alpha
chr4_-_73756673 0.31 ENSDART00000174274
ENSDART00000192913
ENSDART00000113546

si:dkey-262g12.14
zgc:171551
chr21_+_27513859 0.31 ENSDART00000065420
phosphofurin acidic cluster sorting protein 1a
chr25_+_37293312 0.31 ENSDART00000086737
ENSDART00000161595
si:dkey-234i14.9
chr11_-_40204621 0.31 ENSDART00000086287
zinc finger protein 362a
chr8_-_25336589 0.30 ENSDART00000009682
ATP synthase peripheral stalk-membrane subunit b
chr9_+_18829360 0.30 ENSDART00000006514
general transcription factor IIF, polypeptide 2b
chr20_-_26822522 0.30 ENSDART00000146326
ENSDART00000046764
ENSDART00000103234
ENSDART00000143267
GDP-mannose 4,6-dehydratase
chr3_+_40164129 0.30 ENSDART00000102526
growth factor, augmenter of liver regeneration (ERV1 homolog, S. cerevisiae)
chr1_-_55068941 0.29 ENSDART00000152143
ENSDART00000152590
pellino E3 ubiquitin protein ligase 1a
chr7_+_24023653 0.29 ENSDART00000141165
TERF1 (TRF1)-interacting nuclear factor 2
chr6_-_7061086 0.29 ENSDART00000122719
Indian hedgehog homolog b
chr1_+_35985813 0.29 ENSDART00000179634
ENSDART00000139636
ENSDART00000175902
zgc:152968
chr8_+_20455134 0.29 ENSDART00000079618
REX1, RNA exonuclease 1 homolog
chr8_+_32747612 0.28 ENSDART00000142824
hemicentin 2
chr4_-_2637689 0.28 ENSDART00000192550
ENSDART00000021953
ENSDART00000150344
component of oligomeric golgi complex 5
chr4_-_4834347 0.28 ENSDART00000141803
cytochrome c oxidase assembly factor 6
chr13_+_35474235 0.27 ENSDART00000181927
McKusick-Kaufman syndrome
chr22_-_10541372 0.27 ENSDART00000179708
si:dkey-42i9.4
chr9_+_23895711 0.27 ENSDART00000034686
COP9 signalosome subunit 8
chr20_-_7583486 0.27 ENSDART00000144729
ubiquitin specific peptidase 24
chr21_-_32060993 0.26 ENSDART00000131651
si:ch211-160j14.2
chr19_+_2835240 0.26 ENSDART00000190838
CUB domain containing protein 1
chr8_+_26059677 0.26 ENSDART00000009178
IMP (inosine 5'-monophosphate) dehydrogenase 2
chr25_+_16116740 0.26 ENSDART00000139778
fatty acyl CoA reductase 1
chr6_-_55399214 0.26 ENSDART00000168367
cathepsin A
chr5_+_28497956 0.26 ENSDART00000191935
notochord formation related
chr2_+_50608099 0.25 ENSDART00000185805
ENSDART00000111135
neuronal differentiation 6b
chr1_+_12295142 0.25 ENSDART00000158595
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
chr18_+_19456648 0.25 ENSDART00000079695
zwilch kinetochore protein
chr5_+_56277866 0.25 ENSDART00000170610
ENSDART00000028854
ENSDART00000148749
apoptosis antagonizing transcription factor
chr12_-_47648538 0.25 ENSDART00000108477
fumarate hydratase
chr10_+_42521943 0.25 ENSDART00000010420
ENSDART00000075303
ARP1 actin related protein 1, centractin
chr18_+_17725410 0.25 ENSDART00000090608
ring finger and SPRY domain containing 1
chr19_-_18127808 0.24 ENSDART00000108627
sorting nexin 10a
chr1_+_33697170 0.24 ENSDART00000131664
NOP2/Sun RNA methyltransferase family member 3
chr22_+_737211 0.24 ENSDART00000017305
zinc finger protein 76
chr5_-_5326010 0.24 ENSDART00000161946
pre-B-cell leukemia homeobox 3a
chr23_+_26026383 0.24 ENSDART00000141553
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr20_-_52902693 0.23 ENSDART00000166115
ENSDART00000161050
cathepsin Bb
chr17_+_38030327 0.23 ENSDART00000085481
solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
chr24_-_25166720 0.23 ENSDART00000141601
pleckstrin homology-like domain, family B, member 2b
chr5_+_60590796 0.23 ENSDART00000159859
transmembrane protein 132E
chr23_+_36460239 0.23 ENSDART00000172441
LIM domain and actin binding 1a
chr18_-_1258777 0.23 ENSDART00000077106
ENSDART00000129065
UDP glucuronosyltransferase 5 family, polypeptide F1
chr6_-_35052145 0.23 ENSDART00000073970
ENSDART00000185790
UDP-N-acetylglucosamine pyrophosphorylase 1
chr9_-_9415000 0.22 ENSDART00000146210
si:ch211-214p13.9
chr23_-_41965557 0.22 ENSDART00000144183
solute carrier family 1 (glutamate transporter), member 7b
chr24_-_36238054 0.22 ENSDART00000155725
transmembrane protein 241
chr10_+_45089820 0.22 ENSDART00000175481
calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 2
chr6_+_7533601 0.22 ENSDART00000057823
proliferation-associated 2G4, a
chr6_+_40922572 0.22 ENSDART00000133599
ENSDART00000002728
ENSDART00000145153
eukaryotic translation initiation factor 4E nuclear import factor 1
chr13_+_8693410 0.21 ENSDART00000138448
tetratricopeptide repeat domain 7A
chr21_+_15603597 0.21 ENSDART00000138626
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1b
chr16_+_23303859 0.21 ENSDART00000006093
solute carrier family 50 (sugar efflux transporter), member 1
chr8_+_31717175 0.21 ENSDART00000013434
3-oxoacid CoA transferase 1a
chr25_-_20024829 0.20 ENSDART00000140182
ENSDART00000174776
CCR4-NOT transcription complex, subunit 4a
chr6_+_19689464 0.20 ENSDART00000164960
syntaxin 8
chr24_-_24724233 0.20 ENSDART00000127044
ENSDART00000012399
armadillo repeat containing 1
chr8_+_11325310 0.20 ENSDART00000142577
frataxin
chr8_+_18011522 0.20 ENSDART00000136756
single stranded DNA binding protein 3b
chr9_-_11676491 0.19 ENSDART00000022358
zinc finger CCCH-type containing 15
chr9_-_27398369 0.19 ENSDART00000186499
testis expressed 30
chr20_-_54198130 0.19 ENSDART00000160409
ADP-ribosylation factor 6a
chr19_+_5480327 0.19 ENSDART00000148794
junction plakoglobin b
chr10_+_45071603 0.19 ENSDART00000186505
ENSDART00000157573
calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 2
chr6_+_40951227 0.19 ENSDART00000156660
POZ (BTB) and AT hook containing zinc finger 1
chr2_+_24374669 0.19 ENSDART00000133818
nuclear receptor subfamily 2, group F, member 6a
chr24_+_21540842 0.19 ENSDART00000091529
WAS protein family, member 3b
chr17_-_16422654 0.19 ENSDART00000150149
tyrosyl-DNA phosphodiesterase 1
chr15_-_16155729 0.18 ENSDART00000192212
si:ch211-259g3.4
chr14_-_26425416 0.18 ENSDART00000088690
lectin, mannose-binding 2
chr20_+_19006703 0.18 ENSDART00000128435
PIN2/TERF1 interacting, telomerase inhibitor 1
chr11_-_41853874 0.18 ENSDART00000002556
MRT4 homolog, ribosome maturation factor
chr22_-_20695237 0.18 ENSDART00000112722
oogenesis-related gene
chr16_-_43344859 0.18 ENSDART00000058680
proteasome subunit alpha 2
chr7_-_69185124 0.18 ENSDART00000182217
ENSDART00000191359
ubiquitin specific peptidase 10
chr19_-_425145 0.18 ENSDART00000164905
dihydrouridine synthase 3-like (S. cerevisiae)
chr19_-_5103141 0.18 ENSDART00000150952
triosephosphate isomerase 1a
chr22_-_22242884 0.18 ENSDART00000020937
HDGF like 2
chr7_+_20383841 0.18 ENSDART00000052906
si:dkey-33c9.6
chr3_-_15667713 0.18 ENSDART00000026658
zgc:66474
chr24_+_21514283 0.18 ENSDART00000007066
cyclin-dependent kinase 8
chr8_+_11425048 0.17 ENSDART00000018739
tight junction protein 2b (zona occludens 2)
chr9_+_34127005 0.17 ENSDART00000167384
ENSDART00000078065
coagulation factor V
chr25_-_6292560 0.17 ENSDART00000153496
WD repeat domain 61
chr8_+_18555559 0.17 ENSDART00000149523
TGF-beta activated kinase 1/MAP3K7 binding protein 3
chr5_-_1203455 0.17 ENSDART00000172177
surfeit gene 4
chr3_-_26787430 0.17 ENSDART00000087047
RAB40c, member RAS oncogene family
chr4_+_5249494 0.17 ENSDART00000150391
si:ch211-214j24.14
chr8_-_37249813 0.16 ENSDART00000098634
ENSDART00000140233
ENSDART00000061328
RNA binding motif protein 39b
chr11_+_1512571 0.16 ENSDART00000027386
acyl-CoA thioesterase 8
chr18_-_45761868 0.16 ENSDART00000025423
cleavage stimulation factor, 3' pre-RNA, subunit 3
chr13_-_9213207 0.16 ENSDART00000139861
ENSDART00000140524
si:dkey-33c12.11
chr18_+_45958375 0.16 ENSDART00000108636
adaptor-related protein complex 2, mu 1 subunit, b
chr1_+_51721851 0.16 ENSDART00000040397
peroxiredoxin 2
chr25_-_32888115 0.16 ENSDART00000087586
C2 calcium dependent domain containing 4A
chr7_+_24573721 0.16 ENSDART00000173938
ENSDART00000173681
si:dkeyp-75h12.7
chr13_+_2442841 0.15 ENSDART00000114456
ENSDART00000137124
ENSDART00000193737
ENSDART00000189722
ENSDART00000187485
ARFGEF family member 3
chr18_-_29896367 0.15 ENSDART00000191303
C-x(9)-C motif containing 2
chr23_-_29394505 0.15 ENSDART00000017728
phosphogluconate dehydrogenase
chr18_+_14619544 0.15 ENSDART00000010821
UTP4, small subunit processome component
chr9_-_43538328 0.15 ENSDART00000140526
zinc finger protein 385B
chr10_+_36092564 0.15 ENSDART00000086490
SET and MYND domain containing 4
chr9_+_48761455 0.15 ENSDART00000139631
ATP-binding cassette, sub-family B (MDR/TAP), member 11a
chr15_-_17618800 0.15 ENSDART00000157185
ADAM metallopeptidase with thrombospondin type 1 motif, 15b
chr18_-_19456269 0.15 ENSDART00000060363
ribosomal protein L4
chr7_+_5956937 0.14 ENSDART00000170763
histone cluster 1 H2A family member 4
chr24_+_40860320 0.14 ENSDART00000161351
golgi reassembly stacking protein 1b
chr6_-_35052388 0.14 ENSDART00000181000
ENSDART00000170116
UDP-N-acetylglucosamine pyrophosphorylase 1
chr24_+_21621654 0.14 ENSDART00000002595
ribosomal protein L21
chr10_-_43721530 0.13 ENSDART00000025366
centrin 3
chr1_+_49668423 0.13 ENSDART00000150880
testis specific, 10
chr23_-_33679579 0.13 ENSDART00000188674
transcription factor CP2
chr8_-_15129573 0.13 ENSDART00000142358
BCAR3, NSP family adaptor protein
chr6_+_13024448 0.13 ENSDART00000104768
paroxysmal nonkinesigenic dyskinesia
chr10_+_11261576 0.13 ENSDART00000155333
hydroxysteroid dehydrogenase like 2
chr10_+_45059702 0.13 ENSDART00000166945
NudC domain containing 3
chr17_+_28533102 0.13 ENSDART00000156218
MAM domain containing glycosylphosphatidylinositol anchor 2a
chr7_+_27898091 0.12 ENSDART00000186451
ENSDART00000173510
tubby bipartite transcription factor
chr22_-_10541712 0.12 ENSDART00000013933
si:dkey-42i9.4
chr23_+_42272588 0.12 ENSDART00000164907

chr1_-_15797663 0.12 ENSDART00000177122
sarcoglycan zeta
chr2_-_57264262 0.12 ENSDART00000183815
ENSDART00000149829
ENSDART00000088508
ENSDART00000149508
methyl-CpG binding domain protein 3a

Network of associatons between targets according to the STRING database.

First level regulatory network of pax7a+pax7b+prop1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.1 0.4 GO:0018872 arsonoacetate metabolic process(GO:0018872)
0.1 1.3 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.1 0.5 GO:0070129 regulation of mitochondrial translation(GO:0070129) positive regulation of mitochondrial translation(GO:0070131)
0.1 0.4 GO:0034154 toll-like receptor 7 signaling pathway(GO:0034154)
0.1 0.7 GO:0000455 enzyme-directed rRNA pseudouridine synthesis(GO:0000455)
0.1 0.5 GO:0060986 regulation of endocrine process(GO:0044060) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938) endocrine hormone secretion(GO:0060986)
0.1 0.3 GO:0010387 COP9 signalosome assembly(GO:0010387)
0.1 0.4 GO:0038107 nodal signaling pathway involved in determination of left/right asymmetry(GO:0038107) regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145)
0.1 0.4 GO:0006531 aspartate metabolic process(GO:0006531)
0.1 0.4 GO:0000741 karyogamy(GO:0000741) pronuclear fusion(GO:0007344)
0.1 0.4 GO:0032289 central nervous system myelin formation(GO:0032289)
0.1 0.5 GO:0006788 heme oxidation(GO:0006788)
0.1 1.4 GO:0060046 binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.1 0.4 GO:0055071 manganese ion homeostasis(GO:0055071)
0.1 0.3 GO:0021564 vagus nerve development(GO:0021564)
0.1 0.2 GO:0006089 lactate metabolic process(GO:0006089)
0.1 0.3 GO:0006700 C21-steroid hormone biosynthetic process(GO:0006700)
0.1 0.2 GO:0019242 methylglyoxal biosynthetic process(GO:0019242) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.1 0.3 GO:0008592 regulation of Toll signaling pathway(GO:0008592)
0.1 0.2 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) negative regulation of lipid kinase activity(GO:0090219)
0.1 0.4 GO:2001286 caveolin-mediated endocytosis(GO:0072584) negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of caveolin-mediated endocytosis(GO:2001286) negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.0 0.3 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.0 0.2 GO:0070986 left/right axis specification(GO:0070986)
0.0 0.3 GO:0070445 regulation of oligodendrocyte progenitor proliferation(GO:0070445)
0.0 0.4 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.0 0.2 GO:0032782 canalicular bile acid transport(GO:0015722) bile acid secretion(GO:0032782)
0.0 0.1 GO:0021611 facial nerve formation(GO:0021611)
0.0 0.2 GO:0046952 ketone body catabolic process(GO:0046952)
0.0 0.8 GO:1990399 sensory epithelium regeneration(GO:0070654) epithelium regeneration(GO:1990399)
0.0 0.3 GO:0090497 mesenchymal cell migration(GO:0090497)
0.0 0.2 GO:0002159 desmosome assembly(GO:0002159)
0.0 0.6 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.0 0.4 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.0 0.6 GO:0006047 UDP-N-acetylglucosamine metabolic process(GO:0006047)
0.0 0.1 GO:0071498 vitamin K metabolic process(GO:0042373) cellular response to fluid shear stress(GO:0071498)
0.0 0.4 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.0 0.1 GO:0071236 cellular response to antibiotic(GO:0071236) cellular response to toxic substance(GO:0097237)
0.0 0.6 GO:0016584 nucleosome positioning(GO:0016584)
0.0 0.3 GO:0072395 signal transduction involved in cell cycle checkpoint(GO:0072395)
0.0 0.2 GO:0036010 protein localization to endosome(GO:0036010)
0.0 0.3 GO:0006177 GMP biosynthetic process(GO:0006177) GMP metabolic process(GO:0046037)
0.0 0.2 GO:0006108 malate metabolic process(GO:0006108)
0.0 1.9 GO:0008203 cholesterol metabolic process(GO:0008203)
0.0 0.2 GO:0035677 posterior lateral line neuromast hair cell development(GO:0035677)
0.0 0.7 GO:0055064 chloride ion homeostasis(GO:0055064)
0.0 0.0 GO:0006678 glucosylceramide metabolic process(GO:0006678)
0.0 0.3 GO:1904356 regulation of telomere maintenance via telomere lengthening(GO:1904356)
0.0 0.3 GO:0072599 protein targeting to ER(GO:0045047) establishment of protein localization to endoplasmic reticulum(GO:0072599)
0.0 0.1 GO:1900620 acetylcholine biosynthetic process(GO:0008292) acetate ester biosynthetic process(GO:1900620)
0.0 0.4 GO:0050796 regulation of insulin secretion(GO:0050796)
0.0 0.6 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.1 GO:0031063 regulation of histone deacetylation(GO:0031063)
0.0 0.3 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.0 0.6 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 0.1 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 0.1 GO:0060368 regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060368)
0.0 0.3 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.1 GO:0097355 protein localization to heterochromatin(GO:0097355)
0.0 0.1 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.0 0.2 GO:1990748 response to superoxide(GO:0000303) response to oxygen radical(GO:0000305) removal of superoxide radicals(GO:0019430) cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451) cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748)
0.0 0.1 GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518)
0.0 0.2 GO:0019682 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.0 0.5 GO:0051014 actin filament severing(GO:0051014)
0.0 0.1 GO:0060330 regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0 0.4 GO:0032543 mitochondrial translation(GO:0032543)
0.0 0.2 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.5 GO:0035118 embryonic pectoral fin morphogenesis(GO:0035118)
0.0 0.1 GO:0046822 regulation of nucleocytoplasmic transport(GO:0046822)
0.0 0.2 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
0.0 0.3 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.3 GO:0021551 central nervous system morphogenesis(GO:0021551)
0.0 0.5 GO:1904029 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 0.2 GO:0030183 B cell differentiation(GO:0030183)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0097124 cyclin A2-CDK2 complex(GO:0097124)
0.1 0.6 GO:0055087 Ski complex(GO:0055087)
0.1 1.1 GO:0034361 very-low-density lipoprotein particle(GO:0034361)
0.1 0.6 GO:0035060 brahma complex(GO:0035060)
0.1 0.4 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006) catalytic step 1 spliceosome(GO:0071012)
0.1 0.2 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.1 0.2 GO:0019815 B cell receptor complex(GO:0019815)
0.1 0.5 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 0.3 GO:1902636 kinociliary basal body(GO:1902636)
0.0 0.4 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.4 GO:0045171 intercellular bridge(GO:0045171)
0.0 0.8 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.2 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.0 0.4 GO:0005869 dynactin complex(GO:0005869)
0.0 0.2 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 1.0 GO:0032040 small-subunit processome(GO:0032040)
0.0 0.1 GO:0032838 cell projection cytoplasm(GO:0032838)
0.0 0.3 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.6 GO:0005839 proteasome core complex(GO:0005839)
0.0 0.3 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.3 GO:0070187 telosome(GO:0070187)
0.0 0.1 GO:0030891 VCB complex(GO:0030891)
0.0 0.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.4 GO:0030667 secretory granule membrane(GO:0030667)
0.0 0.1 GO:0098556 cytoplasmic side of rough endoplasmic reticulum membrane(GO:0098556)
0.0 0.3 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.0 0.2 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.0 1.5 GO:0000786 nucleosome(GO:0000786)
0.0 0.1 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.0 GO:1990429 Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429)
0.0 0.4 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.2 GO:0030057 desmosome(GO:0030057)
0.0 0.2 GO:0045180 basal cortex(GO:0045180)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:0030228 lipoprotein particle receptor activity(GO:0030228)
0.3 2.1 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.1 0.4 GO:0030792 arsenite methyltransferase activity(GO:0030791) methylarsonite methyltransferase activity(GO:0030792)
0.1 1.4 GO:0035804 structural constituent of egg coat(GO:0035804)
0.1 0.6 GO:0043295 glutathione binding(GO:0043295)
0.1 0.3 GO:0016713 cholesterol monooxygenase (side-chain-cleaving) activity(GO:0008386) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen(GO:0016713)
0.1 0.3 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.1 0.4 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.1 0.3 GO:0009384 UDP-N-acetylglucosamine 2-epimerase activity(GO:0008761) N-acylmannosamine kinase activity(GO:0009384)
0.1 0.5 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.1 0.7 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.1 0.4 GO:0003977 UDP-N-acetylglucosamine diphosphorylase activity(GO:0003977)
0.1 0.6 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.1 0.4 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.1 0.4 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.1 0.2 GO:0070259 tyrosyl-DNA phosphodiesterase activity(GO:0070259)
0.1 0.2 GO:0008929 triose-phosphate isomerase activity(GO:0004807) methylglyoxal synthase activity(GO:0008929)
0.1 0.5 GO:0008494 translation activator activity(GO:0008494)
0.1 0.3 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.2 GO:0015432 canalicular bile acid transmembrane transporter activity(GO:0015126) bile acid-exporting ATPase activity(GO:0015432)
0.0 0.2 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.0 0.3 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.0 0.6 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.5 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.2 GO:0008260 3-oxoacid CoA-transferase activity(GO:0008260)
0.0 0.3 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.0 0.7 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.7 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.4 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.0 0.3 GO:0005113 patched binding(GO:0005113)
0.0 0.1 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.0 0.6 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.2 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.2 GO:0016530 metallochaperone activity(GO:0016530)
0.0 0.1 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.0 0.1 GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.0 0.2 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.5 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.4 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.1 GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422)
0.0 1.0 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.3 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.0 0.3 GO:0008417 fucosyltransferase activity(GO:0008417)
0.0 0.3 GO:0070566 adenylyltransferase activity(GO:0070566)
0.0 0.1 GO:0004373 glycogen (starch) synthase activity(GO:0004373)
0.0 0.4 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.4 GO:0034062 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.0 0.2 GO:0005537 mannose binding(GO:0005537)
0.0 0.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.1 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.0 0.2 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 PID REELIN PATHWAY Reelin signaling pathway
0.0 0.5 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 1.0 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 0.3 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 1.0 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.6 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.3 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.0 0.8 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.5 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.0 0.2 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.0 0.5 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.5 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.4 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.7 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.3 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.6 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.3 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.3 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.2 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.1 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.0 0.2 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.3 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.6 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.2 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.2 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.2 REACTOME GLYCOLYSIS Genes involved in Glycolysis