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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for phf21ab+rfx5

Z-value: 0.92

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Transcription factors associated with phf21ab+rfx5

Gene Symbol Gene ID Gene Info
phf21ab
ENSDARG00000021378 PHD finger protein 21Ab
rfx5
ENSDARG00000063258 regulatory factor X, 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
phf21abdr11_v1_chr25_-_7753207_77532070.985.0e-12Click!
rfx5dr11_v1_chr19_-_7495006_74950060.946.9e-09Click!

Activity profile of phf21ab+rfx5 motif

Sorted Z-values of phf21ab+rfx5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_40352215 5.15 ENSDART00000103992
ttll3
tubulin tyrosine ligase-like family, member 3
chr9_-_41077934 4.13 ENSDART00000100342
ankar
ankyrin and armadillo repeat containing
chr19_+_27589201 3.52 ENSDART00000182060
si:dkeyp-46h3.1
si:dkeyp-46h3.1
chr14_+_6954579 2.79 ENSDART00000060998
nme5
NME/NM23 family member 5
chr19_-_7110617 2.74 ENSDART00000104838
psmb8a
proteasome subunit beta 8A
chr20_+_43396318 2.67 ENSDART00000060910
pimr138
Pim proto-oncogene, serine/threonine kinase, related 138
chr23_+_45538932 2.52 ENSDART00000135602
si:ch73-290k24.6
si:ch73-290k24.6
chr25_+_27873671 2.32 ENSDART00000088817
iqub
IQ motif and ubiquitin domain containing
chr25_+_27873836 2.17 ENSDART00000163801
iqub
IQ motif and ubiquitin domain containing
chr15_+_46386261 2.14 ENSDART00000191793
igsf11
immunoglobulin superfamily member 11
chr3_+_13929860 1.97 ENSDART00000164179
syce2
synaptonemal complex central element protein 2
chr2_-_42958619 1.88 ENSDART00000144317
oc90
otoconin 90
chr13_+_233482 1.72 ENSDART00000102511
cfap36
cilia and flagella associated protein 36
chr20_-_29787192 1.72 ENSDART00000125348
ENSDART00000048759
id2b
inhibitor of DNA binding 2b
chr21_+_33459524 1.60 ENSDART00000053205
cd74b
CD74 molecule, major histocompatibility complex, class II invariant chain b
chr6_+_26309968 1.57 ENSDART00000153805
dzip1l
DAZ interacting zinc finger protein 1-like
chr19_+_43297546 1.56 ENSDART00000168002
laptm5
lysosomal protein transmembrane 5
chr1_-_7570181 1.54 ENSDART00000103588
mxa
myxovirus (influenza) resistance A
chr12_+_17620067 1.43 ENSDART00000073599
rsph10b
radial spoke head 10 homolog B
chr16_-_13516745 1.40 ENSDART00000145410
si:dkeyp-69b9.3
si:dkeyp-69b9.3
chr20_+_39416729 1.37 ENSDART00000099993
ENSDART00000144133
pimr128
Pim proto-oncogene, serine/threonine kinase, related 128
chr21_-_17290941 1.20 ENSDART00000147993
gfi1b
growth factor independent 1B transcription repressor
chr20_+_39394308 1.20 ENSDART00000142554
pimr136
Pim proto-oncogene, serine/threonine kinase, related 136
chr21_-_45920 1.16 ENSDART00000040422
bhmt
betaine-homocysteine methyltransferase
chr16_+_40301056 1.09 ENSDART00000058578
rspo3
R-spondin 3
chr20_+_39373480 1.02 ENSDART00000136714
pimr131
Pim proto-oncogene, serine/threonine kinase, related 131
chr1_+_34203817 0.98 ENSDART00000191432
ENSDART00000046094
arl6
ADP-ribosylation factor-like 6
chr23_-_45539306 0.91 ENSDART00000161913
CU681841.1

chr5_+_58397646 0.78 ENSDART00000180759
HEPACAM
hepatic and glial cell adhesion molecule
chr10_-_8434816 0.59 ENSDART00000108643
tctn1
tectonic family member 1
chr21_-_32097908 0.59 ENSDART00000147387
si:ch211-160j14.3
si:ch211-160j14.3
chr5_+_32141790 0.56 ENSDART00000041504
tescb
tescalcin b
chr4_-_76370630 0.56 ENSDART00000168831
ENSDART00000174313
si:ch73-158p21.3
si:ch73-158p21.3
chr1_+_24366110 0.53 ENSDART00000139913
pimr178
Pim proto-oncogene, serine/threonine kinase, related 178
chr23_+_45025909 0.51 ENSDART00000188105
hmgb2b
high mobility group box 2b
chr22_+_34710036 0.50 ENSDART00000025820
hoga1
4-hydroxy-2-oxoglutarate aldolase 1
chr5_-_54300725 0.48 ENSDART00000163048
slc25a35
solute carrier family 25, member 35
chr22_+_34710473 0.47 ENSDART00000155906
hoga1
4-hydroxy-2-oxoglutarate aldolase 1
chr18_+_49225552 0.46 ENSDART00000135026
si:ch211-136a13.1
si:ch211-136a13.1
chr18_-_8579907 0.44 ENSDART00000147284
FRMD4A
si:ch211-220f12.1
chr20_+_36682051 0.42 ENSDART00000130513
ncoa1
nuclear receptor coactivator 1
chr24_-_21511737 0.37 ENSDART00000109587
rnf6
ring finger protein (C3H2C3 type) 6
chr12_+_32078056 0.31 ENSDART00000152924
stxbp4
syntaxin binding protein 4
chr7_-_56606752 0.30 ENSDART00000138714
sult5a1
sulfotransferase family 5A, member 1
chr7_+_50464500 0.30 ENSDART00000191356
serinc4
serine incorporator 4
chr8_+_36288261 0.28 ENSDART00000191281
CU929676.1

chr25_+_22719852 0.27 ENSDART00000088422
abcc8
ATP-binding cassette, sub-family C (CFTR/MRP), member 8
chr3_-_29941357 0.27 ENSDART00000147732
ENSDART00000137973
ENSDART00000103523
grna
granulin a
chr8_+_45294767 0.27 ENSDART00000191527
ubap2b
ubiquitin associated protein 2b
chr10_+_36092564 0.25 ENSDART00000086490
smyd4
SET and MYND domain containing 4
chr7_+_66822229 0.24 ENSDART00000112109
lyve1a
lymphatic vessel endothelial hyaluronic receptor 1a
chr11_-_24458786 0.24 ENSDART00000089713
mxra8a
matrix-remodelling associated 8a
chr18_+_8340886 0.23 ENSDART00000081132
cpt1b
carnitine palmitoyltransferase 1B (muscle)
chr2_-_49978227 0.23 ENSDART00000142835
hecw1b
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1b
chr11_+_45448212 0.23 ENSDART00000173341
sos1
son of sevenless homolog 1 (Drosophila)
chr13_-_16066997 0.20 ENSDART00000184790
SPATA48
spermatogenesis associated 48
chr2_-_37862380 0.18 ENSDART00000186005
si:ch211-284o19.8
si:ch211-284o19.8
chr18_-_46063773 0.16 ENSDART00000078561
si:ch73-262h23.4
si:ch73-262h23.4
chr5_+_38662125 0.16 ENSDART00000136949
si:dkey-58f10.13
si:dkey-58f10.13
chr1_-_23274393 0.14 ENSDART00000147800
ENSDART00000130277
ENSDART00000054340
ENSDART00000054338
rpl9
ribosomal protein L9
chr19_-_45534392 0.14 ENSDART00000163920
trps1
trichorhinophalangeal syndrome I
chr11_+_1805421 0.13 ENSDART00000173143
lrp1aa
low density lipoprotein receptor-related protein 1Aa
chr18_+_49411417 0.13 ENSDART00000028944
LRFN3
zmp:0000001073
chr8_-_22274222 0.12 ENSDART00000131805
nphp4
nephronophthisis 4
chr4_+_33095657 0.09 ENSDART00000150647
znf1112
zinc finger protein 1112
chr4_-_75678082 0.07 ENSDART00000180201
si:dkey-165o8.1
si:dkey-165o8.1
chr20_+_9211237 0.07 ENSDART00000139527
si:ch211-59d15.4
si:ch211-59d15.4
chr8_+_50727220 0.06 ENSDART00000127062
egr3
early growth response 3
chr23_+_21964325 0.05 ENSDART00000140208
ENSDART00000135690
lactbl1a
lactamase, beta-like 1a
chr2_+_16173999 0.04 ENSDART00000177639
ENSDART00000157601
ENSDART00000190186
ENSDART00000045933
sh3glb1b
SH3-domain GRB2-like endophilin B1b
chr8_-_22273819 0.03 ENSDART00000121513
nphp4
nephronophthisis 4
chr8_-_32878228 0.02 ENSDART00000110897
si:dkey-56i24.1
si:dkey-56i24.1
chr16_-_47301376 0.01 ENSDART00000169697
mios
missing oocyte, meiosis regulator, homolog (Drosophila)

Network of associatons between targets according to the STRING database.

First level regulatory network of phf21ab+rfx5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.8 GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902175) negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902176)
0.5 1.6 GO:0010934 macrophage cytokine production(GO:0010934) regulation of macrophage cytokine production(GO:0010935) positive regulation of macrophage cytokine production(GO:0060907) negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230)
0.3 1.4 GO:0051145 smooth muscle cell differentiation(GO:0051145)
0.3 1.1 GO:0060829 negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060829)
0.2 1.5 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.1 1.0 GO:0046487 glyoxylate metabolic process(GO:0046487)
0.1 1.9 GO:0032309 icosanoid secretion(GO:0032309) arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.1 2.1 GO:0097324 melanocyte migration(GO:0097324)
0.1 2.0 GO:0007130 synaptonemal complex assembly(GO:0007130) synaptonemal complex organization(GO:0070193)
0.1 5.1 GO:0035082 axoneme assembly(GO:0035082)
0.1 2.7 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.1 1.2 GO:0009086 methionine biosynthetic process(GO:0009086)
0.1 0.6 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.0 1.7 GO:0032922 circadian regulation of gene expression(GO:0032922)
0.0 0.3 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.0 0.2 GO:0031063 regulation of histone deacetylation(GO:0031063)
0.0 0.2 GO:2000650 negative regulation of sodium ion transmembrane transporter activity(GO:2000650)
0.0 1.0 GO:0061512 protein localization to cilium(GO:0061512)
0.0 1.2 GO:0060216 definitive hemopoiesis(GO:0060216)
0.0 1.6 GO:0032880 regulation of protein localization(GO:0032880)
0.0 5.0 GO:0046777 protein autophosphorylation(GO:0046777)
0.0 0.2 GO:0009437 carnitine metabolic process(GO:0009437)
0.0 0.3 GO:0051923 sulfation(GO:0051923)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.0 GO:0000801 central element(GO:0000801)
0.2 1.2 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 2.7 GO:0005839 proteasome core complex(GO:0005839)
0.1 7.9 GO:0005930 axoneme(GO:0005930)
0.1 1.5 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
0.0 0.6 GO:0036038 MKS complex(GO:0036038)
0.0 1.6 GO:0036064 ciliary basal body(GO:0036064)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.1 GO:0070738 protein-glycine ligase activity(GO:0070735) tubulin-glycine ligase activity(GO:0070738)
0.1 2.7 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 1.2 GO:0008172 S-methyltransferase activity(GO:0008172)
0.1 1.0 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.1 2.8 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.1 1.6 GO:0042289 MHC class II protein binding(GO:0042289)
0.1 1.9 GO:0004623 phospholipase A2 activity(GO:0004623)
0.1 0.3 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.0 0.4 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.2 GO:0016416 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.0 0.5 GO:0008301 DNA binding, bending(GO:0008301)
0.0 1.1 GO:0008201 heparin binding(GO:0008201)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.3 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 0.2 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.5 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.4 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.2 REACTOME SOS MEDIATED SIGNALLING Genes involved in SOS-mediated signalling
0.0 0.2 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.3 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport