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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for prrx1a+prrx1b
Z-value: 1.59
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Transcription factors associated with prrx1a+prrx1b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| prrx1a | dr11_v1_chr2_-_23172708_23172708 | 0.86 | 4.9e-06 | Click! |
| prrx1b | dr11_v1_chr20_+_34511678_34511678 | 0.56 | 1.7e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr9_-_48397702 Show fit | 5.78 |
ENSDART00000147169
|
zgc:172182 |
|
| chr9_-_48407408 Show fit | 5.12 |
ENSDART00000058248
|
zgc:172182 |
|
| chr8_-_21372446 Show fit | 4.91 |
ENSDART00000061481
ENSDART00000079293 |
elastase 2 like |
|
| chr22_-_15562933 Show fit | 4.44 |
ENSDART00000141528
|
ankyrin repeat and MYND domain containing 1 |
|
| chr10_-_17083180 Show fit | 4.21 |
ENSDART00000170083
|
family with sequence similarity 166, member B |
|
| chr20_-_7072487 Show fit | 4.11 |
ENSDART00000145954
|
si:ch211-121a2.2 |
|
| chr22_-_910926 Show fit | 4.01 |
ENSDART00000180075
|
|
|
| chr9_+_48219111 Show fit | 3.98 |
ENSDART00000111225
ENSDART00000145972 |
coiled-coil domain containing 173 |
|
| chr12_-_990149 Show fit | 3.97 |
ENSDART00000054367
|
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2b |
|
| chr21_+_43404945 Show fit | 3.79 |
ENSDART00000142234
|
FERM domain containing 7 |
Network of associatons between targets according to the STRING database.
First level regulatory network of prrx1a+prrx1b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 43.4 | GO:0046777 | protein autophosphorylation(GO:0046777) |
| 0.1 | 7.5 | GO:0070121 | Kupffer's vesicle development(GO:0070121) |
| 0.5 | 5.1 | GO:0072088 | renal tubule morphogenesis(GO:0061333) nephron tubule morphogenesis(GO:0072078) nephron epithelium morphogenesis(GO:0072088) |
| 0.3 | 4.4 | GO:0051764 | actin crosslink formation(GO:0051764) |
| 0.3 | 4.1 | GO:0043248 | proteasome assembly(GO:0043248) |
| 0.1 | 4.1 | GO:0006096 | glycolytic process(GO:0006096) |
| 0.6 | 4.0 | GO:0006621 | protein retention in ER lumen(GO:0006621) |
| 0.9 | 3.7 | GO:0061113 | pancreas morphogenesis(GO:0061113) |
| 0.2 | 3.5 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.1 | 3.4 | GO:0070831 | basement membrane assembly(GO:0070831) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.8 | GO:0030426 | growth cone(GO:0030426) |
| 0.2 | 4.0 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.1 | 3.6 | GO:0044447 | axoneme part(GO:0044447) |
| 0.0 | 3.4 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.8 | 3.2 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 0.1 | 3.0 | GO:0043679 | axon terminus(GO:0043679) |
| 0.7 | 2.8 | GO:0070319 | Golgi to plasma membrane transport vesicle(GO:0070319) |
| 0.1 | 2.8 | GO:0032156 | septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156) |
| 0.0 | 2.2 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 2.1 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 38.2 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
| 0.0 | 4.6 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 4.4 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 4.2 | GO:0008201 | heparin binding(GO:0008201) |
| 1.3 | 4.0 | GO:0046923 | ER retention sequence binding(GO:0046923) |
| 0.3 | 3.7 | GO:0004029 | aldehyde dehydrogenase (NAD) activity(GO:0004029) |
| 0.0 | 3.7 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.2 | 3.5 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.5 | 3.4 | GO:0050262 | ribosylnicotinamide kinase activity(GO:0050262) |
| 0.8 | 3.3 | GO:0004365 | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.7 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 3.4 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.2 | 2.0 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.1 | 1.9 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.0 | 1.8 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 1.7 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.0 | 1.3 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.0 | 1.1 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 1.1 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.1 | 1.0 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.8 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.5 | 3.7 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.1 | 3.5 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.1 | 3.3 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.2 | 3.0 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.3 | 2.9 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.2 | 2.5 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.0 | 2.2 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 1.8 | REACTOME RNA POL I TRANSCRIPTION INITIATION | Genes involved in RNA Polymerase I Transcription Initiation |
| 0.2 | 1.7 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |