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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for rest
Z-value: 1.41
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Transcription factors associated with rest
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| rest | dr11_v1_chr14_-_52433292_52433292 | -0.79 | 8.5e-05 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_54911458 Show fit | 3.78 |
ENSDART00000089603
|
golgin A7 family, member Ba |
|
| chr22_-_25033105 Show fit | 3.65 |
ENSDART00000124220
|
neuronal pentraxin receptor b |
|
| chr5_-_26093945 Show fit | 3.52 |
ENSDART00000010199
ENSDART00000145096 |
family with sequence similarity 219, member Ab |
|
| chr25_+_5035343 Show fit | 3.10 |
ENSDART00000011751
|
parvin, beta |
|
| chr25_-_19443421 Show fit | 2.84 |
ENSDART00000067362
|
cocaine- and amphetamine-regulated transcript 2 |
|
| chr4_+_357810 Show fit | 2.74 |
ENSDART00000163436
ENSDART00000103645 |
transmembrane protein 181 |
|
| chr25_-_31863374 Show fit | 2.61 |
ENSDART00000028338
|
secretory carrier membrane protein 5a |
|
| chr15_+_41027466 Show fit | 2.56 |
ENSDART00000075940
|
melatonin receptor type 1Ba |
|
| chr21_+_6751405 Show fit | 2.49 |
ENSDART00000037265
ENSDART00000146371 |
olfactomedin 1b |
|
| chr18_+_28988373 Show fit | 2.41 |
ENSDART00000018685
|
synaptotagmin IXa |
Network of associatons between targets according to the STRING database.
First level regulatory network of rest
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.5 | GO:0043631 | mRNA polyadenylation(GO:0006378) RNA polyadenylation(GO:0043631) |
| 0.1 | 3.8 | GO:0018231 | peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231) |
| 0.1 | 3.7 | GO:0014059 | dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059) |
| 0.3 | 3.3 | GO:0099550 | trans-synaptic signalling, modulating synaptic transmission(GO:0099550) |
| 0.1 | 3.1 | GO:0030032 | lamellipodium assembly(GO:0030032) |
| 0.4 | 2.8 | GO:0008343 | adult feeding behavior(GO:0008343) |
| 0.1 | 2.6 | GO:0045956 | positive regulation of calcium ion-dependent exocytosis(GO:0045956) |
| 0.0 | 2.6 | GO:0048511 | rhythmic process(GO:0048511) |
| 0.2 | 2.3 | GO:0032332 | positive regulation of chondrocyte differentiation(GO:0032332) |
| 0.6 | 2.2 | GO:0097112 | gamma-aminobutyric acid receptor clustering(GO:0097112) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.7 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.3 | 4.5 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
| 0.3 | 3.8 | GO:0002178 | palmitoyltransferase complex(GO:0002178) |
| 0.0 | 3.1 | GO:0030018 | Z disc(GO:0030018) |
| 0.5 | 2.7 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) |
| 0.2 | 2.4 | GO:0031045 | dense core granule(GO:0031045) |
| 0.7 | 2.2 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.1 | 2.0 | GO:0034706 | voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706) |
| 0.2 | 1.9 | GO:0030893 | meiotic cohesin complex(GO:0030893) |
| 0.0 | 1.8 | GO:0070382 | exocytic vesicle(GO:0070382) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.2 | GO:0003682 | chromatin binding(GO:0003682) |
| 0.1 | 4.0 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.1 | 3.8 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.1 | 3.7 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 0.1 | 2.7 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.4 | 2.6 | GO:0008502 | melatonin receptor activity(GO:0008502) |
| 0.1 | 2.2 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.2 | 2.0 | GO:0019871 | sodium channel inhibitor activity(GO:0019871) |
| 0.1 | 1.9 | GO:0042162 | telomeric DNA binding(GO:0042162) |
| 0.0 | 1.6 | GO:0005179 | hormone activity(GO:0005179) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.1 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 2.0 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 1.9 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 0.6 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 0.5 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.0 | 0.5 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 0.4 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.5 | REACTOME PROCESSING OF INTRONLESS PRE MRNAS | Genes involved in Processing of Intronless Pre-mRNAs |
| 0.2 | 3.1 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 2.0 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 1.9 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.0 | 1.9 | REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |
| 0.0 | 1.1 | REACTOME G PROTEIN ACTIVATION | Genes involved in G-protein activation |
| 0.0 | 1.1 | REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS | Genes involved in Interactions of Vpr with host cellular proteins |
| 0.1 | 0.9 | REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.0 | 0.8 | REACTOME LIGAND GATED ION CHANNEL TRANSPORT | Genes involved in Ligand-gated ion channel transport |
| 0.1 | 0.5 | REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |