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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for rfx1a+rfx1b

Z-value: 2.17

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Transcription factors associated with rfx1a+rfx1b

Gene Symbol Gene ID Gene Info
rfx1a
ENSDARG00000005883 regulatory factor X, 1a (influences HLA class II expression)
rfx1b
ENSDARG00000075904 regulatory factor X, 1b (influences HLA class II expression)

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
rfx1adr11_v1_chr3_-_19200571_192006510.991.2e-14Click!
rfx1bdr11_v1_chr1_-_54107321_541073210.944.4e-09Click!

Activity profile of rfx1a+rfx1b motif

Sorted Z-values of rfx1a+rfx1b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr9_+_48219111 10.17 ENSDART00000111225
ENSDART00000145972
ccdc173
coiled-coil domain containing 173
chr5_+_61919217 9.46 ENSDART00000097340
rsph4a
radial spoke head 4 homolog A
chr6_-_8264751 9.20 ENSDART00000091628
ccdc151
coiled-coil domain containing 151
chr4_+_15819728 8.80 ENSDART00000101613
lrguk
leucine-rich repeats and guanylate kinase domain containing
chr25_+_21895182 8.46 ENSDART00000152075
si:ch211-147k9.8
si:ch211-147k9.8
chr1_+_22002649 8.40 ENSDART00000141317
dnah6
dynein, axonemal, heavy chain 6
chr5_-_29671586 8.01 ENSDART00000098336
spaca9
sperm acrosome associated 9
chr14_+_6954579 7.96 ENSDART00000060998
nme5
NME/NM23 family member 5
chr5_+_39563301 7.94 ENSDART00000131245
ENSDART00000097872
si:ch211-57h10.1
si:ch211-57h10.1
chr1_-_6225285 7.90 ENSDART00000141653
mdh1b
malate dehydrogenase 1B, NAD (soluble)
chr20_-_3915770 7.82 ENSDART00000159322
si:ch73-111k22.3
si:ch73-111k22.3
chr20_-_31075972 7.23 ENSDART00000122927
si:ch211-198b3.4
si:ch211-198b3.4
chr22_+_3223489 7.00 ENSDART00000082011
lim2.2
lens intrinsic membrane protein 2.2
chr20_+_21022641 6.82 ENSDART00000152561
ENSDART00000141591
si:dkey-219e20.2
si:dkey-219e20.2
chr1_+_47831619 6.77 ENSDART00000110335
ENSDART00000101066
cfap58
cilia and flagella associated protein 58
chr5_+_29671681 6.62 ENSDART00000043096
ak8
adenylate kinase 8
chr10_-_29744921 6.42 ENSDART00000088605
ift46
intraflagellar transport 46 homolog (Chlamydomonas)
chr17_+_27545183 6.22 ENSDART00000129392
pacrg
PARK2 co-regulated
chr2_-_58085444 6.08 ENSDART00000166395
fcer1gl
Fc receptor, IgE, high affinity I, gamma polypeptide like
chr17_-_33716688 6.03 ENSDART00000043651
dnal1
dynein, axonemal, light chain 1
chr12_-_145076 5.96 ENSDART00000160926
dnah9
dynein, axonemal, heavy chain 9
chr11_-_12232929 5.83 ENSDART00000127611
si:ch211-156l18.4
si:ch211-156l18.4
chr2_-_1569250 5.75 ENSDART00000167202
dab1b
Dab, reelin signal transducer, homolog 1b (Drosophila)
chr10_-_17232372 5.46 ENSDART00000135679
rab36
RAB36, member RAS oncogene family
chr8_+_53204027 5.42 ENSDART00000135353
CFAP74
cilia and flagella associated protein 74
chr11_-_12549110 5.38 ENSDART00000148014
zgc:174354
zgc:174354
chr15_+_22267847 5.35 ENSDART00000110665
spa17
sperm autoantigenic protein 17
chr24_-_37003577 5.35 ENSDART00000137777
dnaaf3
dynein, axonemal, assembly factor 3
chr18_+_2168695 5.35 ENSDART00000165855
dnaaf4
dynein axonemal assembly factor 4
chr13_+_24717880 5.30 ENSDART00000147713
cfap43
cilia and flagella associated protein 43
chr7_+_23515966 5.24 ENSDART00000186893
ENSDART00000186189
zgc:109889
zgc:109889
chr10_-_36682509 5.21 ENSDART00000148093
ENSDART00000063365
dnajb13
DnaJ (Hsp40) homolog, subfamily B, member 13
chr17_+_11500628 5.11 ENSDART00000155660
efcab2
EF-hand calcium binding domain 2
chr6_+_515181 5.10 ENSDART00000171374
CACNA1I (1 of many)
si:ch73-379f7.5
chr20_-_4766645 5.06 ENSDART00000147071
ENSDART00000152398
ak7a
adenylate kinase 7a
chr3_-_60175470 5.03 ENSDART00000156597
si:ch73-364h19.1
si:ch73-364h19.1
chr7_-_34505985 4.99 ENSDART00000173806
ENSDART00000024869
tex9
testis expressed 9
chr7_-_40738774 4.97 ENSDART00000084179
rnf32
ring finger protein 32
chr3_-_61593274 4.97 ENSDART00000154132
ENSDART00000055071
nptx2a
neuronal pentraxin 2a
chr2_+_7075220 4.91 ENSDART00000022963
cdc14aa
cell division cycle 14Aa
chr5_+_32260502 4.88 ENSDART00000149020
si:ch211-158m24.12
si:ch211-158m24.12
chr1_+_50538839 4.87 ENSDART00000020412
pkd2
polycystic kidney disease 2
chr15_-_23206562 4.85 ENSDART00000110360
ccdc153
coiled-coil domain containing 153
chr19_+_9091673 4.83 ENSDART00000052898
si:ch211-81a5.5
si:ch211-81a5.5
chr13_+_33117528 4.82 ENSDART00000085719
si:ch211-10a23.2
si:ch211-10a23.2
chr19_+_27589201 4.77 ENSDART00000182060
si:dkeyp-46h3.1
si:dkeyp-46h3.1
chr25_-_4192637 4.62 ENSDART00000153832
ppp1r32
protein phosphatase 1, regulatory subunit 32
chr10_-_17231917 4.62 ENSDART00000038577
rab36
RAB36, member RAS oncogene family
chr24_-_17067284 4.54 ENSDART00000111237
armc3
armadillo repeat containing 3
chr15_+_44053244 4.51 ENSDART00000059550
lrrc51
leucine rich repeat containing 51
chr17_-_4395373 4.49 ENSDART00000015923
klhl10a
kelch-like family member 10a
chr25_-_28638052 4.45 ENSDART00000138918
ENSDART00000135247
ENSDART00000114662
ENSDART00000157493
ENSDART00000137677
agbl2
ATP/GTP binding protein-like 2
chr11_-_30352333 4.33 ENSDART00000030794
tmem169a
transmembrane protein 169a
chr4_-_12795436 4.32 ENSDART00000131026
ENSDART00000075127
b2m
beta-2-microglobulin
chr2_+_13462305 4.30 ENSDART00000149309
ENSDART00000080900
cfap57
cilia and flagella associated protein 57
chr1_+_22003173 4.27 ENSDART00000054388
dnah6
dynein, axonemal, heavy chain 6
chr2_-_7696503 4.25 ENSDART00000169709
CABZ01055306.1

chr17_+_23937262 4.23 ENSDART00000113276
si:ch211-189k9.2
si:ch211-189k9.2
chr13_+_48482256 4.21 ENSDART00000053332
FOXN2 (1 of many)
forkhead box N2
chr7_+_38445938 4.20 ENSDART00000173467
cep89
centrosomal protein 89
chr11_+_37652870 4.18 ENSDART00000129918
kif17
kinesin family member 17
chr22_+_25049563 4.08 ENSDART00000078173
dzank1
double zinc ribbon and ankyrin repeat domains 1
chr11_-_12417952 4.06 ENSDART00000135694
si:dkey-27d5.9
si:dkey-27d5.9
chr19_-_40186328 4.01 ENSDART00000087474
efcab1
EF-hand calcium binding domain 1
chr7_-_28403930 4.00 ENSDART00000076496
stk33
serine/threonine kinase 33
chr8_-_50525360 3.99 ENSDART00000175648
CABZ01060030.1

chr11_-_12512122 3.97 ENSDART00000145338
si:dkey-27d5.3
si:dkey-27d5.3
chr20_-_32007209 3.96 ENSDART00000021575
adgb
androglobin
chr12_-_36521767 3.83 ENSDART00000110290
unc13d
unc-13 homolog D (C. elegans)
chr6_+_18251140 3.81 ENSDART00000169752
ccdc40
coiled-coil domain containing 40
chr24_+_2843268 3.77 ENSDART00000170529
si:ch211-152c8.2
si:ch211-152c8.2
chr2_-_7696287 3.77 ENSDART00000190769
CABZ01055306.1

chr19_+_17400283 3.76 ENSDART00000127353
nr1d2b
nuclear receptor subfamily 1, group D, member 2b
chr1_+_11711226 3.68 ENSDART00000147623
si:dkey-26i13.8
si:dkey-26i13.8
chr12_-_11649690 3.57 ENSDART00000149713
btbd16
BTB (POZ) domain containing 16
chr17_-_24684687 3.49 ENSDART00000105457
morn2
MORN repeat containing 2
chr13_-_6218248 3.46 ENSDART00000159052
si:zfos-1056e6.1
si:zfos-1056e6.1
chr5_+_43807003 3.45 ENSDART00000097625
zgc:158640
zgc:158640
chr13_+_24679674 3.43 ENSDART00000033090
ENSDART00000139854
zgc:66426
zgc:66426
chr12_+_17620067 3.20 ENSDART00000073599
rsph10b
radial spoke head 10 homolog B
chr23_-_42752550 3.19 ENSDART00000187059
si:ch73-217n20.1
si:ch73-217n20.1
chr6_-_40842768 3.19 ENSDART00000076160
mustn1a
musculoskeletal, embryonic nuclear protein 1a
chr18_-_31051847 3.19 ENSDART00000170982
gas8
growth arrest-specific 8
chr17_+_53250802 3.13 ENSDART00000143819
VASH1
vasohibin 1
chr10_-_7988396 3.06 ENSDART00000141445
ENSDART00000024282
ewsr1a
EWS RNA-binding protein 1a
chr18_+_16192083 3.01 ENSDART00000133042
lrriq1
leucine-rich repeats and IQ motif containing 1
chr4_+_20177526 2.97 ENSDART00000017947
ENSDART00000135451
ccdc146
coiled-coil domain containing 146
chr20_-_12642685 2.95 ENSDART00000173257
si:dkey-97l20.6
si:dkey-97l20.6
chr2_-_42960353 2.89 ENSDART00000098303
oc90
otoconin 90
chr14_+_24283915 2.86 ENSDART00000172868
klhl3
kelch-like family member 3
chr11_+_11374021 2.82 ENSDART00000170806
si:dkey-23f9.8
si:dkey-23f9.8
chr14_+_35892802 2.79 ENSDART00000135079
zgc:63568
zgc:63568
chr25_+_25438165 2.79 ENSDART00000161369
LRRC56
si:ch211-103e16.5
chr15_-_1022436 2.76 ENSDART00000156003
znf1010
zinc finger protein 1010
chr13_-_7767548 2.70 ENSDART00000158720
ENSDART00000121952
h2afy2
H2A histone family, member Y2
chr13_-_48764180 2.69 ENSDART00000167157
si:ch1073-266p11.2
si:ch1073-266p11.2
chr3_-_12026741 2.63 ENSDART00000132238
cfap70
cilia and flagella associated protein 70
chr10_-_10864331 2.62 ENSDART00000122657
nrarpa
NOTCH regulated ankyrin repeat protein a
chr17_-_31695217 2.57 ENSDART00000104332
ENSDART00000143090
lin52
lin-52 DREAM MuvB core complex component
chr25_+_18436301 2.53 ENSDART00000056180
cep41
centrosomal protein 41
chr5_+_37087583 2.51 ENSDART00000049900
tagln2
transgelin 2
chr3_-_57425961 2.51 ENSDART00000033716
socs3a
suppressor of cytokine signaling 3a
chr11_+_11347031 2.51 ENSDART00000172429
ENSDART00000193128
si:dkey-23f9.6
si:dkey-23f9.6
chr3_+_24458899 2.50 ENSDART00000156655
cbx6b
chromobox homolog 6b
chr13_-_31470439 2.49 ENSDART00000076574
rtn1a
reticulon 1a
chr10_-_10863936 2.47 ENSDART00000180568
nrarpa
NOTCH regulated ankyrin repeat protein a
chr16_-_54640315 2.44 ENSDART00000101207
spag1b
sperm associated antigen 1b
chr8_+_7144066 2.34 ENSDART00000146306
slc6a6a
solute carrier family 6 (neurotransmitter transporter), member 6a
chr24_-_36910224 2.28 ENSDART00000079233
dnaaf3l
dynein, axonemal, assembly factor 3 like
chr16_+_34493987 2.26 ENSDART00000138374
si:ch211-255i3.4
si:ch211-255i3.4
chr23_+_21638258 2.23 ENSDART00000104188
igsf21b
immunoglobin superfamily, member 21b
chr2_-_29761965 2.23 ENSDART00000142057
ENSDART00000110595
si:dkey-188g12.1
si:dkey-188g12.1
chr1_+_8662530 2.22 ENSDART00000054989
fscn1b
fascin actin-bundling protein 1b
chr8_-_50147948 2.22 ENSDART00000149010
hp
haptoglobin
chr11_+_11360641 2.21 ENSDART00000159765
si:dkey-23f9.7
si:dkey-23f9.7
chr9_-_40873934 2.19 ENSDART00000066424
pofut2
protein O-fucosyltransferase 2
chr25_+_35942867 2.17 ENSDART00000066985
hsd17b2
hydroxysteroid (17-beta) dehydrogenase 2
chr20_+_30797329 2.16 ENSDART00000145066
nhsl1b
NHS-like 1b
chr11_-_12232769 2.09 ENSDART00000180116
si:ch211-156l18.4
si:ch211-156l18.4
chr19_-_10648523 2.08 ENSDART00000059358
tekt2
tektin 2 (testicular)
chr14_+_24277556 2.07 ENSDART00000122660
hnrnpa0a
heterogeneous nuclear ribonucleoprotein A0a
chr3_-_6719232 2.06 ENSDART00000154294
atg4db
autophagy related 4D, cysteine peptidase b
chr3_+_60044780 2.04 ENSDART00000080437
zgc:113030
zgc:113030
chr5_-_33022014 2.03 ENSDART00000061149
zgc:55461
zgc:55461
chr1_+_54683655 2.03 ENSDART00000132785
knop1
lysine-rich nucleolar protein 1
chr25_+_25438322 1.97 ENSDART00000150364
LRRC56
si:ch211-103e16.5
chr17_-_29119362 1.96 ENSDART00000104204
foxg1a
forkhead box G1a
chr8_-_36469117 1.95 ENSDART00000111240
mhc2dab
major histocompatibility complex class II DAB gene
chr6_+_52350443 1.93 ENSDART00000151612
ENSDART00000151349
si:ch211-239j9.1
si:ch211-239j9.1
chr17_+_33767890 1.93 ENSDART00000193177
fut8a
fucosyltransferase 8a (alpha (1,6) fucosyltransferase)
chr10_+_2529037 1.93 ENSDART00000123467
zmp:0000001301
zmp:0000001301
chr1_-_45633955 1.92 ENSDART00000044057
sept3
septin 3
chr6_-_7711349 1.91 ENSDART00000032494
ttc26
tetratricopeptide repeat domain 26
chr7_-_50395059 1.88 ENSDART00000191150
vps33b
vacuolar protein sorting 33B
chr11_+_44723019 1.86 ENSDART00000168531
irf2bp2b
interferon regulatory factor 2 binding protein 2b
chr24_+_39186940 1.85 ENSDART00000155817
spsb3b
splA/ryanodine receptor domain and SOCS box containing 3b
chr2_-_43123949 1.81 ENSDART00000075347
ENSDART00000132346
lrrc6
leucine rich repeat containing 6
chr9_+_9112159 1.81 ENSDART00000165932
sik1
salt-inducible kinase 1
chr4_-_2545310 1.76 ENSDART00000150619
ENSDART00000140760
e2f7
E2F transcription factor 7
chr9_+_40874194 1.74 ENSDART00000141548
hibch
3-hydroxyisobutyryl-CoA hydrolase
chr12_-_36521947 1.70 ENSDART00000152946
unc13d
unc-13 homolog D (C. elegans)
chr11_-_18799827 1.70 ENSDART00000185438
ENSDART00000189116
ENSDART00000180504
pfkfb2b
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2b
chr24_-_37472727 1.68 ENSDART00000134152
cluap1
clusterin associated protein 1
chr13_-_47556447 1.62 ENSDART00000131239
acoxl
acyl-CoA oxidase-like
chr20_-_46554440 1.59 ENSDART00000043298
ENSDART00000060680
fosab
v-fos FBJ murine osteosarcoma viral oncogene homolog Ab
chr6_+_13933464 1.58 ENSDART00000109144
ptprnb
protein tyrosine phosphatase, receptor type, Nb
chr8_+_25267903 1.57 ENSDART00000093090
ampd2b
adenosine monophosphate deaminase 2b
chr22_-_10891213 1.57 ENSDART00000145229
arhgef18b
rho/rac guanine nucleotide exchange factor (GEF) 18b
chr1_-_49498116 1.55 ENSDART00000137357
zgc:175214
zgc:175214
chr24_-_39772045 1.53 ENSDART00000087441
GFOD1
si:ch211-276f18.2
chr2_+_6126638 1.50 ENSDART00000153916
fzr1b
fizzy/cell division cycle 20 related 1b
chr23_+_44157682 1.50 ENSDART00000164474
ENSDART00000149928
si:ch73-106g13.1
si:ch73-106g13.1
chr14_+_1351214 1.50 ENSDART00000007091
bbs12
Bardet-Biedl syndrome 12
chr5_-_52813442 1.50 ENSDART00000169305
zgc:158260
zgc:158260
chr18_-_17531483 1.48 ENSDART00000061000
bbs2
Bardet-Biedl syndrome 2
chr20_+_4060839 1.47 ENSDART00000178565
TRIM67
tripartite motif containing 67
chr24_+_40860320 1.43 ENSDART00000161351
gorasp1b
golgi reassembly stacking protein 1b
chr21_-_22317920 1.39 ENSDART00000191083
ENSDART00000108701
gdpd4b
glycerophosphodiester phosphodiesterase domain containing 4b
chr1_+_11711503 1.36 ENSDART00000138355
si:dkey-26i13.8
si:dkey-26i13.8
chr4_-_78026285 1.36 ENSDART00000168273
CCT2
chaperonin containing TCP1 subunit 2
chr17_+_21964472 1.32 ENSDART00000063704
ENSDART00000188904
crip3
cysteine-rich protein 3
chr15_+_13984879 1.27 ENSDART00000159438
zgc:162730
zgc:162730
chr16_+_11779534 1.26 ENSDART00000133497
si:dkey-250k15.4
si:dkey-250k15.4
chr7_+_27059330 1.26 ENSDART00000173919
plekha7b
pleckstrin homology domain containing, family A member 7b
chr5_+_69856153 1.25 ENSDART00000124128
ENSDART00000073663
ugt2a6
UDP glucuronosyltransferase 2 family, polypeptide A6
chr1_-_21538673 1.24 ENSDART00000131257
wdr19
WD repeat domain 19
chr4_+_77971104 1.24 ENSDART00000188609
zgc:113921
zgc:113921
chr16_+_11779761 1.24 ENSDART00000140297
si:dkey-250k15.4
si:dkey-250k15.4
chr4_+_13615731 1.22 ENSDART00000141395
ENSDART00000144310
ccdc87
coiled-coil domain containing 87
chr14_-_21219659 1.20 ENSDART00000089867
ppp2r2cb
protein phosphatase 2, regulatory subunit B, gamma b
chr17_+_43595692 1.16 ENSDART00000156271
cfap99
cilia and flagella associated protein 99
chr11_-_18800299 1.15 ENSDART00000156276
pfkfb2b
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2b
chr23_+_2760573 1.15 ENSDART00000129719
top1
DNA topoisomerase I
chr13_+_28854438 1.12 ENSDART00000193407
ENSDART00000189554
CU639469.1

chr21_+_21612214 1.11 ENSDART00000008099
b9d2
B9 domain containing 2
chr5_-_52243424 1.06 ENSDART00000159078
erap2
endoplasmic reticulum aminopeptidase 2
chr18_-_43884044 1.06 ENSDART00000087382
ddx6
DEAD (Asp-Glu-Ala-Asp) box helicase 6
chr1_+_55662491 1.02 ENSDART00000152386
adgre8
adhesion G protein-coupled receptor E8
chr1_-_21538329 1.00 ENSDART00000182798
ENSDART00000193518
ENSDART00000183873
ENSDART00000183376
wdr19
WD repeat domain 19
chr8_-_49345388 0.99 ENSDART00000053203
plp2
proteolipid protein 2
chr21_+_9576176 0.97 ENSDART00000161289
ENSDART00000159899
ENSDART00000162834
mapk10
mitogen-activated protein kinase 10
chr21_+_21611867 0.97 ENSDART00000189148
b9d2
B9 domain containing 2
chr10_-_44482911 0.97 ENSDART00000085556
hip1ra
huntingtin interacting protein 1 related a
chr8_-_19216180 0.95 ENSDART00000146162
si:ch73-222f22.2
si:ch73-222f22.2
chr16_+_46111849 0.95 ENSDART00000172232
sv2a
synaptic vesicle glycoprotein 2A
chr4_-_23858900 0.94 ENSDART00000123199
usp6nl
USP6 N-terminal like
chr12_+_4971515 0.92 ENSDART00000161076
arhgap27
Rho GTPase activating protein 27
chr16_+_9726038 0.91 ENSDART00000192988
ENSDART00000020859
pip5k1ab
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, b
chr15_+_37589698 0.91 ENSDART00000076066
ENSDART00000153894
ENSDART00000156298
lin37
lin-37 DREAM MuvB core complex component
chr10_+_25204626 0.90 ENSDART00000024514
chordc1b
cysteine and histidine-rich domain (CHORD) containing 1b
chr17_-_10838434 0.88 ENSDART00000064597
lgals3b
lectin, galactoside binding soluble 3b
chr24_-_9960290 0.88 ENSDART00000143390
ENSDART00000092975
ENSDART00000184953
vps41
vacuolar protein sorting 41 homolog (S. cerevisiae)
chr18_+_29950233 0.86 ENSDART00000146431
atmin
ATM interactor
chr11_-_24428237 0.85 ENSDART00000189107
ENSDART00000103752
dvl1b
dishevelled segment polarity protein 1b
chr19_-_8604429 0.84 ENSDART00000151165
trim46b
tripartite motif containing 46b
chr24_+_744713 0.84 ENSDART00000067764
stk17a
serine/threonine kinase 17a
chr4_-_9557186 0.84 ENSDART00000150569
shank3b
SH3 and multiple ankyrin repeat domains 3b
chr16_+_5202042 0.82 ENSDART00000145368
soga3a
SOGA family member 3a
chr11_+_1575435 0.81 ENSDART00000155713
ENSDART00000156562
si:dkey-40c23.1
si:dkey-40c23.1
chr10_+_37981471 0.75 ENSDART00000113112
ENSDART00000185102
wscd1b
WSC domain containing 1b

Network of associatons between targets according to the STRING database.

First level regulatory network of rfx1a+rfx1b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 8.0 GO:1902176 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902175) negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902176)
1.8 5.3 GO:0036159 inner dynein arm assembly(GO:0036159)
1.6 4.9 GO:0071498 cellular response to fluid shear stress(GO:0071498)
1.6 7.9 GO:0006107 oxaloacetate metabolic process(GO:0006107)
1.1 4.4 GO:0035610 protein side chain deglutamylation(GO:0035610)
1.1 22.5 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
1.0 11.5 GO:0060294 cilium movement involved in cell motility(GO:0060294)
1.0 2.9 GO:0072156 distal tubule morphogenesis(GO:0072156)
0.8 3.1 GO:0061181 regulation of chondrocyte development(GO:0061181)
0.8 5.3 GO:0007288 sperm axoneme assembly(GO:0007288)
0.7 5.7 GO:0097476 spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477)
0.7 7.8 GO:0001881 receptor recycling(GO:0001881)
0.6 16.1 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.6 3.2 GO:0035988 chondrocyte proliferation(GO:0035988)
0.6 1.9 GO:0045649 regulation of macrophage differentiation(GO:0045649)
0.6 4.2 GO:0098971 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937) anterograde dendritic transport of neurotransmitter receptor complex(GO:0098971)
0.5 3.2 GO:0035889 otolith tethering(GO:0035889)
0.5 4.5 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.4 14.0 GO:0042073 intraciliary transport(GO:0042073)
0.4 5.1 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.4 1.6 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.4 2.3 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.4 2.2 GO:0006004 fucose metabolic process(GO:0006004)
0.4 1.8 GO:0042023 regulation of DNA endoreduplication(GO:0032875) positive regulation of DNA endoreduplication(GO:0032877) DNA endoreduplication(GO:0042023)
0.3 2.1 GO:0036372 opsin transport(GO:0036372)
0.3 2.5 GO:0048681 negative regulation of axon regeneration(GO:0048681) negative regulation of neuron projection regeneration(GO:0070571)
0.3 4.3 GO:0045824 negative regulation of toll-like receptor signaling pathway(GO:0034122) negative regulation of innate immune response(GO:0045824)
0.3 1.7 GO:0006574 valine catabolic process(GO:0006574)
0.3 2.7 GO:0000022 mitotic spindle elongation(GO:0000022) positive regulation of cytokinesis(GO:0032467) spindle elongation(GO:0051231) mitotic spindle midzone assembly(GO:0051256)
0.3 1.5 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.2 2.0 GO:0043584 nose development(GO:0043584)
0.2 10.9 GO:0003341 cilium movement(GO:0003341)
0.2 3.5 GO:0051127 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.2 0.6 GO:0090278 negative regulation of peptide secretion(GO:0002792) negative regulation of peptide hormone secretion(GO:0090278)
0.2 2.9 GO:0032309 icosanoid secretion(GO:0032309) arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.2 2.5 GO:0018095 protein polyglutamylation(GO:0018095)
0.2 2.2 GO:0097475 motor neuron migration(GO:0097475)
0.2 2.9 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.2 0.9 GO:0072677 eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677) positive regulation of calcium ion import(GO:0090280)
0.2 5.2 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.2 11.7 GO:0009142 nucleoside triphosphate biosynthetic process(GO:0009142)
0.1 0.4 GO:0030299 intestinal cholesterol absorption(GO:0030299)
0.1 1.5 GO:0051877 pigment granule aggregation in cell center(GO:0051877)
0.1 1.1 GO:0034063 stress granule assembly(GO:0034063)
0.1 1.9 GO:0036065 fucosylation(GO:0036065)
0.1 0.9 GO:0042249 establishment of planar polarity of embryonic epithelium(GO:0042249) establishment of planar polarity involved in neural tube closure(GO:0090177) regulation of establishment of planar polarity involved in neural tube closure(GO:0090178) planar cell polarity pathway involved in neural tube closure(GO:0090179)
0.1 1.2 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.1 1.5 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.1 1.6 GO:0061026 cardiac muscle tissue regeneration(GO:0061026)
0.1 1.6 GO:0032264 IMP salvage(GO:0032264)
0.1 0.9 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.1 4.0 GO:0042770 signal transduction in response to DNA damage(GO:0042770)
0.1 1.1 GO:0002483 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous antigen(GO:0019883) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.1 0.6 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.1 0.2 GO:1901232 regulation of convergent extension involved in axis elongation(GO:1901232) positive regulation of epiboly involved in gastrulation with mouth forming second(GO:1904088)
0.1 1.9 GO:0035622 intrahepatic bile duct development(GO:0035622)
0.1 0.5 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.1 1.1 GO:0006265 DNA topological change(GO:0006265)
0.1 1.7 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.1 5.6 GO:0044782 cilium organization(GO:0044782)
0.1 2.3 GO:0072348 sulfur compound transport(GO:0072348)
0.1 2.4 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.1 1.1 GO:0019882 antigen processing and presentation(GO:0019882)
0.0 1.8 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 3.1 GO:0051966 regulation of synaptic transmission, glutamatergic(GO:0051966)
0.0 0.3 GO:0070293 renal absorption(GO:0070293)
0.0 0.2 GO:0070084 protein initiator methionine removal(GO:0070084)
0.0 1.2 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 19.4 GO:0006397 mRNA processing(GO:0006397)
0.0 1.0 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.6 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.0 0.3 GO:0006596 polyamine biosynthetic process(GO:0006596)
0.0 2.2 GO:0051017 actin filament bundle assembly(GO:0051017)
0.0 0.1 GO:0007638 mechanosensory behavior(GO:0007638)
0.0 0.7 GO:0046847 filopodium assembly(GO:0046847)
0.0 1.9 GO:0061640 cytoskeleton-dependent cytokinesis(GO:0061640)
0.0 1.0 GO:0006986 response to unfolded protein(GO:0006986)
0.0 0.5 GO:1901379 regulation of potassium ion transmembrane transport(GO:1901379)
0.0 1.0 GO:0048484 enteric nervous system development(GO:0048484)
0.0 2.3 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.0 0.6 GO:0046890 regulation of lipid biosynthetic process(GO:0046890)
0.0 1.1 GO:0007030 Golgi organization(GO:0007030)
0.0 0.1 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 9.5 GO:0001534 radial spoke(GO:0001534)
2.0 6.1 GO:0032998 Fc receptor complex(GO:0032997) Fc-epsilon receptor I complex(GO:0032998)
0.8 8.0 GO:0001669 acrosomal vesicle(GO:0001669)
0.8 14.1 GO:0030992 intraciliary transport particle B(GO:0030992)
0.8 4.5 GO:0060091 kinocilium(GO:0060091) kinociliary basal body(GO:1902636)
0.7 4.3 GO:0042612 MHC class I protein complex(GO:0042612)
0.4 2.2 GO:0030991 intraciliary transport particle A(GO:0030991)
0.4 1.9 GO:0033263 CORVET complex(GO:0033263)
0.4 5.9 GO:0031209 SCAR complex(GO:0031209)
0.3 12.9 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.3 17.1 GO:0031514 motile cilium(GO:0031514)
0.3 18.5 GO:0030286 dynein complex(GO:0030286)
0.3 4.0 GO:0016328 lateral plasma membrane(GO:0016328)
0.2 0.7 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.2 2.7 GO:0097431 mitotic spindle pole(GO:0097431)
0.2 0.9 GO:0030897 HOPS complex(GO:0030897)
0.1 1.1 GO:0042611 MHC protein complex(GO:0042611)
0.1 7.7 GO:0036064 ciliary basal body(GO:0036064)
0.1 0.9 GO:0001772 immunological synapse(GO:0001772)
0.1 2.9 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 3.1 GO:0005758 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.1 1.9 GO:0099569 presynaptic cytoskeleton(GO:0099569)
0.1 5.8 GO:0055037 recycling endosome(GO:0055037)
0.0 1.1 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 2.2 GO:0005902 microvillus(GO:0005902)
0.0 2.1 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.1 GO:0010369 chromocenter(GO:0010369)
0.0 0.6 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.2 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.0 1.8 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 1.8 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 1.0 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 15.1 GO:0005829 cytosol(GO:0005829)
0.0 0.2 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 11.7 GO:0004127 cytidylate kinase activity(GO:0004127)
2.0 6.1 GO:0019763 immunoglobulin receptor activity(GO:0019763) IgE receptor activity(GO:0019767)
1.8 8.8 GO:0004385 guanylate kinase activity(GO:0004385)
1.6 7.9 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.9 5.3 GO:0030331 estrogen receptor binding(GO:0030331)
0.7 5.9 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.5 2.2 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.5 6.0 GO:0043014 alpha-tubulin binding(GO:0043014)
0.4 6.2 GO:0030544 Hsp70 protein binding(GO:0030544)
0.4 12.4 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.4 2.3 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.3 8.0 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.3 4.9 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.3 1.6 GO:0003997 acyl-CoA oxidase activity(GO:0003997)
0.3 1.5 GO:1990757 anaphase-promoting complex binding(GO:0010997) ubiquitin ligase activator activity(GO:1990757)
0.3 9.2 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.2 4.1 GO:0008417 fucosyltransferase activity(GO:0008417)
0.2 1.8 GO:0001217 bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding(GO:0001130) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217)
0.2 2.9 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.2 2.5 GO:0070740 protein-glutamic acid ligase activity(GO:0070739) tubulin-glutamic acid ligase activity(GO:0070740)
0.2 0.9 GO:0019863 IgE binding(GO:0019863) immunoglobulin binding(GO:0019865)
0.2 4.4 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.2 5.2 GO:0051087 chaperone binding(GO:0051087)
0.1 1.6 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.1 4.0 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 1.7 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 1.0 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1 2.4 GO:0004623 phospholipase A2 activity(GO:0004623)
0.1 1.1 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.1 1.0 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1 0.3 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.1 6.6 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 2.5 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1 0.6 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.1 1.7 GO:0016289 CoA hydrolase activity(GO:0016289)
0.1 28.1 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 2.3 GO:1901682 sulfur compound transmembrane transporter activity(GO:1901682)
0.1 4.6 GO:0019902 phosphatase binding(GO:0019902)
0.0 4.5 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.6 GO:0042910 xenobiotic transporter activity(GO:0042910)
0.0 1.2 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 2.2 GO:0030674 protein binding, bridging(GO:0030674)
0.0 2.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.4 GO:0004859 phospholipase inhibitor activity(GO:0004859) lipase inhibitor activity(GO:0055102)
0.0 0.5 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 5.4 GO:0005516 calmodulin binding(GO:0005516)
0.0 3.8 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879)
0.0 10.9 GO:0003924 GTPase activity(GO:0003924)
0.0 0.1 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.0 1.9 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 6.3 GO:0008017 microtubule binding(GO:0008017)
0.0 0.9 GO:0005109 frizzled binding(GO:0005109)
0.0 1.3 GO:0008146 sulfotransferase activity(GO:0008146)
0.0 1.1 GO:0003724 RNA helicase activity(GO:0003724)
0.0 0.5 GO:0016307 phosphatidylinositol phosphate kinase activity(GO:0016307)
0.0 1.7 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.3 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.1 1.0 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 0.6 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 1.1 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 1.8 PID E2F PATHWAY E2F transcription factor network
0.0 0.9 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.3 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 0.9 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 4.3 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 3.5 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.1 1.0 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 1.7 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 1.4 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.1 1.1 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.1 0.2 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 0.6 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 1.5 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.6 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.3 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin