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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for rfx3_rfx2+rfx4

Z-value: 15.64

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Transcription factors associated with rfx3_rfx2+rfx4

Gene Symbol Gene ID Gene Info
rfx3
ENSDARG00000014550 regulatory factor X, 3 (influences HLA class II expression)
rfx2
ENSDARG00000013575 regulatory factor X, 2 (influences HLA class II expression)
rfx4
ENSDARG00000026395 regulatory factor X, 4
rfx4
ENSDARG00000116861 regulatory factor X, 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
rfx3dr11_v1_chr10_-_641609_6416090.991.2e-13Click!
rfx2dr11_v1_chr8_-_20138054_201382510.951.1e-09Click!
rfx4dr11_v1_chr18_-_15373620_153736200.175.0e-01Click!

Activity profile of rfx3_rfx2+rfx4 motif

Sorted Z-values of rfx3_rfx2+rfx4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr20_-_3915770 68.54 ENSDART00000159322
si:ch73-111k22.3
si:ch73-111k22.3
chr3_-_1190132 66.60 ENSDART00000149709
smdt1a
single-pass membrane protein with aspartate-rich tail 1a
chr4_-_5652030 59.33 ENSDART00000010903
rsph9
radial spoke head 9 homolog
chr4_-_13626831 58.00 ENSDART00000173077
si:dkeyp-81f3.4
si:dkeyp-81f3.4
chr23_-_28692581 57.99 ENSDART00000078141
ribc1
RIB43A domain with coiled-coils 1
chr25_+_21895182 55.95 ENSDART00000152075
si:ch211-147k9.8
si:ch211-147k9.8
chr10_-_36682509 55.34 ENSDART00000148093
ENSDART00000063365
dnajb13
DnaJ (Hsp40) homolog, subfamily B, member 13
chr5_+_39563301 54.78 ENSDART00000131245
ENSDART00000097872
si:ch211-57h10.1
si:ch211-57h10.1
chr19_-_4023050 54.15 ENSDART00000162883
stpg1
sperm-tail PG-rich repeat containing 1
chr16_+_4497302 53.67 ENSDART00000081826
ENSDART00000148096
ttc29
tetratricopeptide repeat domain 29
chr25_-_10571078 53.41 ENSDART00000153898
si:ch211-107e6.5
si:ch211-107e6.5
chr13_+_111212 53.08 ENSDART00000167840
dnaaf2
dynein, axonemal, assembly factor 2
chr7_-_20778574 52.83 ENSDART00000078421
ENSDART00000190023
cyb5d1
cytochrome b5 domain containing 1
chr5_-_57920600 52.78 ENSDART00000132376
si:dkey-27p23.3
si:dkey-27p23.3
chr1_-_10806625 52.39 ENSDART00000139749
si:ch73-222h13.1
si:ch73-222h13.1
chr20_+_33739059 51.69 ENSDART00000140361
ppil6
peptidylprolyl isomerase (cyclophilin)-like 6
chr20_-_32658305 51.19 ENSDART00000140622
ENSDART00000152909
si:dkey-6f10.3
si:dkey-6f10.3
chr20_-_13640598 50.29 ENSDART00000128823
ENSDART00000103394
rsph3
radial spoke 3 homolog
chr5_+_42386705 50.16 ENSDART00000143034
pimr58
Pim proto-oncogene, serine/threonine kinase, related 58
chr5_+_42407962 50.16 ENSDART00000188489
BX548073.11

chr1_+_22427135 49.84 ENSDART00000147193
si:dkey-234d14.2
si:dkey-234d14.2
chr5_-_42661012 49.46 ENSDART00000158339
pimr58
Pim proto-oncogene, serine/threonine kinase, related 58
chr3_+_31945604 49.40 ENSDART00000114957
zgc:193811
zgc:193811
chr23_-_20133994 49.06 ENSDART00000004871
lrrc23
leucine rich repeat containing 23
chr15_-_20939579 48.88 ENSDART00000152371
usp2a
ubiquitin specific peptidase 2a
chr17_-_39779906 48.61 ENSDART00000155181
pimr61
Pim proto-oncogene, serine/threonine kinase, related 61
chr16_-_33930060 48.60 ENSDART00000110743
ENSDART00000101898
dnali1
dynein, axonemal, light intermediate chain 1
chr5_+_42379517 48.38 ENSDART00000103325
pimr59
Pim proto-oncogene, serine/threonine kinase, related 59
chr10_-_17232372 47.53 ENSDART00000135679
rab36
RAB36, member RAS oncogene family
chr15_+_44053244 47.50 ENSDART00000059550
lrrc51
leucine rich repeat containing 51
chr5_+_42393896 47.37 ENSDART00000189550
BX548073.13

chr3_-_22829710 47.34 ENSDART00000055659
cyb561
cytochrome b561
chr25_+_13157165 47.25 ENSDART00000155653
si:dkeyp-50b9.1
si:dkeyp-50b9.1
chr5_+_42400777 47.10 ENSDART00000183114
BX548073.8

chr12_-_145076 47.02 ENSDART00000160926
dnah9
dynein, axonemal, heavy chain 9
chr21_-_22557469 46.08 ENSDART00000167230
cfap53
cilia and flagella associated protein 53
chr3_+_60716904 46.02 ENSDART00000168280
foxj1a
forkhead box J1a
chr5_-_23200880 45.90 ENSDART00000051531
iqcd
IQ motif containing D
chr17_-_39772999 45.77 ENSDART00000155727
pimr60
Pim proto-oncogene, serine/threonine kinase, related 60
chr10_-_17231917 45.49 ENSDART00000038577
rab36
RAB36, member RAS oncogene family
chr2_-_14272083 45.18 ENSDART00000169986
tctex1d1
Tctex1 domain containing 1
chr6_-_21582444 45.08 ENSDART00000151339
si:dkey-43k4.3
si:dkey-43k4.3
chr14_+_3944826 44.71 ENSDART00000170167
lrp2bp
LRP2 binding protein
chr13_+_9408101 44.16 ENSDART00000091502
si:ch211-243o19.4
si:ch211-243o19.4
chr9_+_9441453 43.96 ENSDART00000081859
ENSDART00000188567
ENSDART00000143101
maats1
MYCBP-associated, testis expressed 1
chr8_+_23809843 43.79 ENSDART00000099724
si:ch211-163l21.10
si:ch211-163l21.10
chr16_-_45069882 43.35 ENSDART00000058384
gapdhs
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
chr24_+_13277573 43.08 ENSDART00000137886
si:ch211-171b20.3
si:ch211-171b20.3
chr2_-_1569250 42.22 ENSDART00000167202
dab1b
Dab, reelin signal transducer, homolog 1b (Drosophila)
chr25_+_37480285 42.16 ENSDART00000166187
CABZ01095001.1

chr11_-_12437234 41.95 ENSDART00000169324
zgc:174355
zgc:174355
chr21_+_18292535 41.48 ENSDART00000170205
ENSDART00000169676
ENSDART00000163063
dnai1.1
dynein, axonemal, intermediate chain 1, paralog 1
chr7_+_41295974 41.44 ENSDART00000173568
ENSDART00000173544
si:dkey-86l18.10
si:dkey-86l18.10
chr5_-_71705191 41.35 ENSDART00000187767
ak1
adenylate kinase 1
chr13_+_33117528 40.28 ENSDART00000085719
si:ch211-10a23.2
si:ch211-10a23.2
chr21_+_17956856 40.17 ENSDART00000080431
dnai1.2
dynein, axonemal, intermediate chain 1, paralog 2
chr13_-_36703164 39.11 ENSDART00000044357
cdkl1
cyclin-dependent kinase-like 1 (CDC2-related kinase)
chr25_-_28638052 39.09 ENSDART00000138918
ENSDART00000135247
ENSDART00000114662
ENSDART00000157493
ENSDART00000137677
agbl2
ATP/GTP binding protein-like 2
chr13_+_33304187 38.47 ENSDART00000075826
ENSDART00000145295
dcdc2b
doublecortin domain containing 2B
chr17_-_24684687 38.07 ENSDART00000105457
morn2
MORN repeat containing 2
chr8_-_44586981 37.92 ENSDART00000026831
ENSDART00000113945
rsph14
radial spoke head 14 homolog
chr11_-_12379541 37.86 ENSDART00000171717
zgc:174353
zgc:174353
chr13_+_24717880 37.80 ENSDART00000147713
cfap43
cilia and flagella associated protein 43
chr11_-_12717004 37.61 ENSDART00000122020
si:ch211-209f22.3
si:ch211-209f22.3
chr5_-_8406192 37.29 ENSDART00000159718
spef2
sperm flagellar 2
chr25_+_13731542 37.27 ENSDART00000161012
ccdc135
coiled-coil domain containing 135
chr6_+_120181 37.25 ENSDART00000151209
ENSDART00000185930
cdkn2d
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr2_-_14271874 37.13 ENSDART00000189390
tctex1d1
Tctex1 domain containing 1
chr1_+_57269441 37.08 ENSDART00000149688
mycbpap
mycbp associated protein
chr20_-_2667902 36.60 ENSDART00000036373
cfap206
cilia and flagella associated protein 206
chr21_+_22423286 36.27 ENSDART00000133190
capslb
calcyphosine-like b
chr11_-_12334546 36.27 ENSDART00000127768
zgc:91850
zgc:91850
chr4_-_390431 36.10 ENSDART00000067482
ENSDART00000138500
dynlt1
dynein, light chain, Tctex-type 1
chr2_+_35728033 35.88 ENSDART00000002094
ankrd45
ankyrin repeat domain 45
chr13_-_6218248 35.70 ENSDART00000159052
si:zfos-1056e6.1
si:zfos-1056e6.1
chr21_+_22828500 35.42 ENSDART00000151109
si:rp71-1p14.7
si:rp71-1p14.7
chr17_-_45164291 35.40 ENSDART00000062109
noxred1
NADP-dependent oxidoreductase domain containing 1
chr10_-_29744921 35.15 ENSDART00000088605
ift46
intraflagellar transport 46 homolog (Chlamydomonas)
chr5_-_54672763 34.79 ENSDART00000159009
spag8
sperm associated antigen 8
chr10_-_9410068 34.08 ENSDART00000041382
morn5
MORN repeat containing 5
chr11_+_11430552 33.68 ENSDART00000160339
si:dkey-23f9.11
si:dkey-23f9.11
chr2_-_33455164 33.38 ENSDART00000134024
ENSDART00000132221
ccdc24
coiled-coil domain containing 24
chr5_+_56965177 33.19 ENSDART00000097409
ENSDART00000157239
tmem232
transmembrane protein 232
chr11_-_12364122 32.94 ENSDART00000170129
zgc:174353
zgc:174353
chr25_+_32525131 32.93 ENSDART00000156145
scaper
S-phase cyclin A-associated protein in the ER
chr17_+_14425219 32.92 ENSDART00000153994
ccdc175
coiled-coil domain containing 175
chr5_+_66353750 32.85 ENSDART00000143410
si:ch211-261c8.5
si:ch211-261c8.5
chr2_+_2181709 32.74 ENSDART00000092763
ENSDART00000148553
ccdc13
coiled-coil domain containing 13
chr18_-_41232297 32.66 ENSDART00000036928
fbxo36a
F-box protein 36a
chr19_-_40186328 32.32 ENSDART00000087474
efcab1
EF-hand calcium binding domain 1
chr20_+_27691307 32.17 ENSDART00000153299
si:dkey-1h6.8
si:dkey-1h6.8
chr17_-_8753354 32.09 ENSDART00000154593
tex36
testis expressed 36
chr12_-_47793857 31.51 ENSDART00000161294
dydc2
DPY30 domain containing 2
chr16_-_54640315 31.17 ENSDART00000101207
spag1b
sperm associated antigen 1b
chr23_+_35708730 31.09 ENSDART00000009277
tuba1a
tubulin, alpha 1a
chr8_-_13315304 31.07 ENSDART00000142596
kcnn1b
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1b
chr11_-_12499116 31.03 ENSDART00000134836
si:dkey-27d5.4
si:dkey-27d5.4
chr22_-_25033105 31.00 ENSDART00000124220
nptxrb
neuronal pentraxin receptor b
chr7_-_28403930 30.84 ENSDART00000076496
stk33
serine/threonine kinase 33
chr1_+_11711226 30.73 ENSDART00000147623
si:dkey-26i13.8
si:dkey-26i13.8
chr5_-_65969959 30.68 ENSDART00000170677
ttc16
tetratricopeptide repeat domain 16
chr15_+_33865312 30.12 ENSDART00000166141
tekt1
tektin 1
chr1_-_17715493 30.07 ENSDART00000133027
si:dkey-256e7.8
si:dkey-256e7.8
chr11_-_12483302 29.97 ENSDART00000135031
si:dkey-27d5.5
si:dkey-27d5.5
chr11_-_12350419 29.94 ENSDART00000166732
si:dkey-27d5.14
si:dkey-27d5.14
chr6_+_26309968 29.80 ENSDART00000153805
dzip1l
DAZ interacting zinc finger protein 1-like
chr24_-_5911973 29.56 ENSDART00000077933
ENSDART00000077922
pimr64
Pim proto-oncogene, serine/threonine kinase, related 64
chr22_+_2937485 29.49 ENSDART00000082222
ENSDART00000135507
ENSDART00000143258
cep19
centrosomal protein 19
chr11_-_12394682 29.44 ENSDART00000172447
si:dkey-27d5.10
si:dkey-27d5.10
chr7_-_41295356 29.25 ENSDART00000074175
si:dkey-86l18.8
si:dkey-86l18.8
chr18_-_7097403 29.18 ENSDART00000003748
cfap161
cilia and flagella associated protein 161
chr8_-_13315567 29.13 ENSDART00000132685
ENSDART00000168635
kcnn1b
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1b
chr7_+_21321317 28.80 ENSDART00000173950
dnah2
dynein, axonemal, heavy chain 2
chr18_+_30028135 28.74 ENSDART00000140825
ENSDART00000145306
ENSDART00000136810
si:ch211-220f16.1
si:ch211-220f16.1
chr11_-_12363941 28.71 ENSDART00000192304
zgc:174353
zgc:174353
chr7_-_52388734 28.66 ENSDART00000174186
wdr93
WD repeat domain 93
chr8_-_7504146 28.63 ENSDART00000148339
ENSDART00000140098
cdk20
cyclin-dependent kinase 20
chr6_-_16804001 28.60 ENSDART00000155398
pimr40
Pim proto-oncogene, serine/threonine kinase, related 40
chr18_+_46382484 28.55 ENSDART00000024202
ENSDART00000142790
daw1
dynein assembly factor with WDR repeat domains 1
chr5_+_66353589 28.52 ENSDART00000138246
si:ch211-261c8.5
si:ch211-261c8.5
chr5_-_33022014 28.38 ENSDART00000061149
zgc:55461
zgc:55461
chr20_+_18225329 28.32 ENSDART00000144172
kctd1
potassium channel tetramerization domain containing 1
chr24_+_26345427 28.27 ENSDART00000089756
lrrc34
leucine rich repeat containing 34
chr9_-_27771339 28.24 ENSDART00000135722
ENSDART00000140381
si:rp71-45g20.11
si:rp71-45g20.11
chr17_-_6600899 28.22 ENSDART00000154074
ENSDART00000180912
ANKRD66
si:ch211-189e2.2
chr11_-_12530304 28.13 ENSDART00000143061
zgc:174354
zgc:174354
chr2_+_19578079 27.97 ENSDART00000144413
pimr50
Pim proto-oncogene, serine/threonine kinase, related 50
chr2_+_19633493 27.93 ENSDART00000147989
pimr54
Pim proto-oncogene, serine/threonine kinase, related 54
chr23_+_31245395 27.84 ENSDART00000053588
irak1bp1
interleukin-1 receptor-associated kinase 1 binding protein 1
chr14_+_23518110 27.76 ENSDART00000112930
si:ch211-221f10.2
si:ch211-221f10.2
chr11_-_12379359 27.65 ENSDART00000187551
zgc:174353
zgc:174353
chr3_-_12026741 27.64 ENSDART00000132238
cfap70
cilia and flagella associated protein 70
chr9_-_44289636 27.52 ENSDART00000110411
cerkl
ceramide kinase-like
chr18_-_27897217 27.36 ENSDART00000175259
iqcg
IQ motif containing G
chr7_-_41295511 27.28 ENSDART00000173455
si:dkey-86l18.8
si:dkey-86l18.8
chr24_+_17269849 27.23 ENSDART00000017605
spag6
sperm associated antigen 6
chr6_+_15762647 27.09 ENSDART00000127133
ENSDART00000128939
iqca1
IQ motif containing with AAA domain 1
chr6_+_7250824 27.04 ENSDART00000177226
dzip1
DAZ interacting zinc finger protein 1
chr11_-_12619789 26.88 ENSDART00000185508
CR450764.10

chr8_+_18615938 26.76 ENSDART00000089161
si:ch211-232d19.4
si:ch211-232d19.4
chr2_+_19522082 26.63 ENSDART00000146098
pimr49
Pim proto-oncogene, serine/threonine kinase, related 49
chr23_+_12134839 26.39 ENSDART00000128551
ENSDART00000141204
ttll9
tubulin tyrosine ligase-like family, member 9
chr11_-_12472006 26.32 ENSDART00000160558
si:dkey-27d5.6
si:dkey-27d5.6
chr10_-_34889053 26.10 ENSDART00000136966
ccdc169
coiled-coil domain containing 169
chr25_+_13731726 25.97 ENSDART00000181065
ccdc135
coiled-coil domain containing 135
chr18_+_21273749 25.91 ENSDART00000143265
hydin
HYDIN, axonemal central pair apparatus protein
chr4_+_20177526 25.90 ENSDART00000017947
ENSDART00000135451
ccdc146
coiled-coil domain containing 146
chr9_-_16853462 25.75 ENSDART00000160273
CT573248.2

chr4_-_76154252 25.43 ENSDART00000161269
BX957252.1

chr17_+_7513673 25.39 ENSDART00000156674
klhl10b.1
kelch-like family member 10b, tandem duplicate 1
chr17_+_46864116 25.28 ENSDART00000156250
pimr27
Pim proto-oncogene, serine/threonine kinase, related 27
chr21_-_22828593 24.95 ENSDART00000150993
angptl5
angiopoietin-like 5
chr14_+_8725216 24.67 ENSDART00000157630
pimr57
Pim proto-oncogene, serine/threonine kinase, related 57
chr6_+_46258866 24.67 ENSDART00000134584
zgc:162324
zgc:162324
chr2_+_52122663 24.61 ENSDART00000111266
theg
theg spermatid protein
chr2_-_19630297 24.61 ENSDART00000100111
ENSDART00000142173
pimr51
BX088713.2
Pim proto-oncogene, serine/threonine kinase, related 51

chr25_+_27873671 24.60 ENSDART00000088817
iqub
IQ motif and ubiquitin domain containing
chr24_-_6678640 24.45 ENSDART00000042478
enkur
enkurin, TRPC channel interacting protein
chr8_+_21195420 24.44 ENSDART00000100234
ENSDART00000091307
col2a1a
collagen, type II, alpha 1a
chr2_-_19576640 24.33 ENSDART00000141021
pimr51
Pim proto-oncogene, serine/threonine kinase, related 51
chr11_-_12437052 24.32 ENSDART00000190890
ENSDART00000183980
zgc:174355
zgc:174355
chr19_+_46240171 24.25 ENSDART00000162785
mapk15
mitogen-activated protein kinase 15
chr11_-_12634017 24.23 ENSDART00000158286
ENSDART00000193090
CR450764.1

chr5_+_23190642 24.21 ENSDART00000144846
cfap73
cilia and flagella associated protein 73
chr1_+_49651016 24.18 ENSDART00000074380
ENSDART00000101017
tsga10
testis specific, 10
chr9_+_23748342 23.84 ENSDART00000019053
faima
Fas apoptotic inhibitory molecule a
chr18_+_35173683 23.75 ENSDART00000192545
cfap45
cilia and flagella associated protein 45
chr24_+_5912635 23.73 ENSDART00000153736
pimr63
Pim proto-oncogene, serine/threonine kinase, related 63
chr17_+_28882977 23.72 ENSDART00000153937
prkd1
protein kinase D1
chr23_+_13928346 23.57 ENSDART00000155326
si:dkey-90a13.10
si:dkey-90a13.10
chr17_-_46817295 23.52 ENSDART00000155904
pimr24
Pim proto-oncogene, serine/threonine kinase, related 24
chr13_+_9408445 23.47 ENSDART00000162415
si:ch211-243o19.4
si:ch211-243o19.4
chr8_+_53204027 23.42 ENSDART00000135353
CFAP74
cilia and flagella associated protein 74
chr15_-_18162647 23.30 ENSDART00000012064
pih1d2
PIH1 domain containing 2
chr25_+_27873836 23.18 ENSDART00000163801
iqub
IQ motif and ubiquitin domain containing
chr10_-_29236860 23.18 ENSDART00000111620
ccdc83
coiled-coil domain containing 83
chr9_+_23748133 23.17 ENSDART00000180758
faima
Fas apoptotic inhibitory molecule a
chr18_+_35173859 23.14 ENSDART00000127379
ENSDART00000098292
cfap45
cilia and flagella associated protein 45
chr6_+_16895685 23.03 ENSDART00000154090
pimr28
Pim proto-oncogene, serine/threonine kinase, related 28
chr11_-_12471837 22.98 ENSDART00000113175
ENSDART00000186965
si:dkey-27d5.6
si:dkey-27d5.6
chr19_-_9472893 22.75 ENSDART00000045565
ENSDART00000137505
vamp1
vesicle-associated membrane protein 1
chr1_-_3295045 22.55 ENSDART00000157572
gpc5a
glypican 5a
chr11_-_12301939 22.43 ENSDART00000184239
CABZ01022564.1

chr14_-_36799280 22.35 ENSDART00000168615
rnf130
ring finger protein 130
chr13_-_13662624 22.25 ENSDART00000143269
pimr47
Pim proto-oncogene, serine/threonine kinase, related 47
chr18_-_29962234 22.24 ENSDART00000144996
si:ch73-103b9.2
si:ch73-103b9.2
chr20_+_591505 22.18 ENSDART00000046438
kcnk2b
potassium channel, subfamily K, member 2b
chr6_+_16870004 22.17 ENSDART00000154794
pimr21
Pim proto-oncogene, serine/threonine kinase, related 21
chr11_-_12394500 22.15 ENSDART00000140221
si:dkey-27d5.10
si:dkey-27d5.10
chr5_+_22633188 22.11 ENSDART00000128781
mtnr1c
melatonin receptor 1C
chr14_+_30762131 22.07 ENSDART00000145039
si:ch211-145o7.3
si:ch211-145o7.3
chr2_-_29761965 21.95 ENSDART00000142057
ENSDART00000110595
si:dkey-188g12.1
si:dkey-188g12.1
chr20_-_7080427 21.95 ENSDART00000140166
ENSDART00000023677
si:ch211-121a2.2
si:ch211-121a2.2
chr18_-_29961784 21.93 ENSDART00000135601
ENSDART00000140661
si:ch73-103b9.2
si:ch73-103b9.2
chr10_+_31222656 21.87 ENSDART00000140988
ENSDART00000143387
tmem218
transmembrane protein 218
chr17_+_53250802 21.75 ENSDART00000143819
VASH1
vasohibin 1
chr2_+_19578446 21.70 ENSDART00000164758
pimr50
Pim proto-oncogene, serine/threonine kinase, related 50
chr17_-_46933567 21.61 ENSDART00000157274
pimr25
Pim proto-oncogene, serine/threonine kinase, related 25
chr20_+_20637866 21.59 ENSDART00000060203
ENSDART00000079079
rtn1b
reticulon 1b
chr24_+_26345609 21.48 ENSDART00000186844
lrrc34
leucine rich repeat containing 34

Network of associatons between targets according to the STRING database.

First level regulatory network of rfx3_rfx2+rfx4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
22.2 155.5 GO:0007288 sperm axoneme assembly(GO:0007288)
19.8 59.3 GO:1904158 axonemal central apparatus assembly(GO:1904158)
12.5 62.7 GO:0003356 regulation of cilium beat frequency(GO:0003356)
9.8 39.1 GO:0035610 protein side chain deglutamylation(GO:0035610)
9.2 27.5 GO:2000425 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902175) negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902176) regulation of apoptotic cell clearance(GO:2000425)
8.2 238.5 GO:0070286 axonemal dynein complex assembly(GO:0070286)
8.1 57.0 GO:0044458 motile cilium assembly(GO:0044458)
7.6 15.2 GO:0090660 cerebrospinal fluid circulation(GO:0090660)
7.0 49.1 GO:0032475 otolith formation(GO:0032475)
6.5 39.2 GO:0089700 protein kinase D signaling(GO:0089700) regulation of lymphangiogenesis(GO:1901490)
5.9 41.4 GO:0006172 ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180)
5.9 29.5 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
5.7 68.5 GO:0001881 receptor recycling(GO:0001881)
5.4 54.2 GO:1902686 positive regulation of mitochondrial membrane permeability(GO:0035794) positive regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902110) mitochondrial outer membrane permeabilization involved in programmed cell death(GO:1902686)
5.3 42.2 GO:0097476 spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477)
5.0 95.3 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
4.5 45.4 GO:0021631 optic nerve morphogenesis(GO:0021631)
4.5 63.2 GO:0030317 sperm motility(GO:0030317)
4.4 57.3 GO:0035082 axoneme assembly(GO:0035082)
4.3 30.1 GO:0060294 cilium movement involved in cell motility(GO:0060294)
4.3 47.0 GO:1902042 regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902041) negative regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902042)
4.2 54.7 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
3.9 35.4 GO:0055129 proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129)
3.9 66.6 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
3.5 31.5 GO:0006348 chromatin silencing at telomere(GO:0006348)
3.5 145.0 GO:0003341 cilium movement(GO:0003341)
3.0 11.8 GO:0098908 regulation of neuronal action potential(GO:0098908)
2.7 8.0 GO:0061469 regulation of type B pancreatic cell proliferation(GO:0061469)
2.6 929.8 GO:0046777 protein autophosphorylation(GO:0046777)
2.5 15.3 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
2.5 27.7 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
2.4 4.8 GO:0048245 eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
2.2 26.4 GO:0018095 protein polyglutamylation(GO:0018095)
2.0 15.6 GO:0036372 opsin transport(GO:0036372)
1.9 5.7 GO:0046069 cGMP catabolic process(GO:0046069)
1.8 38.5 GO:0032474 otolith morphogenesis(GO:0032474)
1.8 7.2 GO:0007638 mechanosensory behavior(GO:0007638)
1.7 55.3 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
1.7 51.7 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
1.7 36.4 GO:0042073 intraciliary transport(GO:0042073)
1.6 11.4 GO:1905097 regulation of guanyl-nucleotide exchange factor activity(GO:1905097) regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
1.6 17.7 GO:0097105 presynaptic membrane organization(GO:0097090) postsynaptic membrane assembly(GO:0097104) presynaptic membrane assembly(GO:0097105)
1.6 12.8 GO:0033137 negative regulation of peptidyl-serine phosphorylation(GO:0033137)
1.5 22.7 GO:0035493 SNARE complex assembly(GO:0035493)
1.3 24.0 GO:0046686 response to cadmium ion(GO:0046686)
1.3 749.6 GO:0006397 mRNA processing(GO:0006397)
1.3 5.2 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
1.3 16.7 GO:0030819 activation of adenylate cyclase activity(GO:0007190) positive regulation of cAMP metabolic process(GO:0030816) positive regulation of cAMP biosynthetic process(GO:0030819) positive regulation of adenylate cyclase activity(GO:0045762)
1.2 7.4 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
1.2 10.7 GO:0051877 pigment granule aggregation in cell center(GO:0051877)
1.1 27.8 GO:0030322 stabilization of membrane potential(GO:0030322)
1.1 16.5 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
1.0 16.3 GO:0036065 fucosylation(GO:0036065)
1.0 14.1 GO:0032309 icosanoid secretion(GO:0032309) arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
1.0 21.1 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
1.0 16.4 GO:0044773 mitotic DNA damage checkpoint(GO:0044773) mitotic DNA integrity checkpoint(GO:0044774)
1.0 77.4 GO:0006165 nucleoside diphosphate phosphorylation(GO:0006165)
0.9 3.8 GO:0010812 negative regulation of cell-substrate adhesion(GO:0010812)
0.9 3.8 GO:0071169 establishment of protein localization to chromosome(GO:0070199) establishment of protein localization to chromatin(GO:0071169)
0.9 7.5 GO:0001780 neutrophil homeostasis(GO:0001780)
0.9 4.7 GO:0070378 ERK5 cascade(GO:0070375) regulation of ERK5 cascade(GO:0070376) positive regulation of ERK5 cascade(GO:0070378)
0.9 68.4 GO:0044782 cilium organization(GO:0044782)
0.8 8.1 GO:0071941 nitrogen cycle metabolic process(GO:0071941)
0.8 28.0 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.7 9.4 GO:0009086 methionine biosynthetic process(GO:0009086)
0.7 18.8 GO:0003323 type B pancreatic cell development(GO:0003323)
0.7 16.4 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.7 27.0 GO:0030199 collagen fibril organization(GO:0030199)
0.7 4.1 GO:0033183 negative regulation of histone ubiquitination(GO:0033183) regulation of protein K63-linked ubiquitination(GO:1900044) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) regulation of protein polyubiquitination(GO:1902914) negative regulation of protein polyubiquitination(GO:1902915)
0.6 3.6 GO:0071908 determination of intestine left/right asymmetry(GO:0071908)
0.6 28.4 GO:1902749 regulation of cell cycle G2/M phase transition(GO:1902749)
0.6 21.2 GO:0015804 neutral amino acid transport(GO:0015804)
0.6 20.1 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.5 6.0 GO:0032048 cardiolipin metabolic process(GO:0032048) phosphatidylglycerol metabolic process(GO:0046471)
0.5 15.1 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.5 17.3 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.5 13.0 GO:0031114 regulation of microtubule depolymerization(GO:0031114)
0.5 5.0 GO:0042989 sequestering of actin monomers(GO:0042989)
0.5 9.0 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.5 22.1 GO:0032922 circadian regulation of gene expression(GO:0032922)
0.5 60.6 GO:0016579 protein deubiquitination(GO:0016579)
0.5 20.7 GO:0051057 positive regulation of Ras protein signal transduction(GO:0046579) positive regulation of small GTPase mediated signal transduction(GO:0051057)
0.5 3.2 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.4 8.9 GO:0006415 translational termination(GO:0006415)
0.4 8.2 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511)
0.4 1.7 GO:0030718 RNA 5'-end processing(GO:0000966) germ-line stem cell population maintenance(GO:0030718)
0.4 86.0 GO:0060271 cilium morphogenesis(GO:0060271)
0.4 12.5 GO:1903670 regulation of sprouting angiogenesis(GO:1903670)
0.4 4.0 GO:0022615 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.4 4.2 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
0.4 1.8 GO:0061011 hepatic duct development(GO:0061011)
0.4 11.8 GO:0007340 acrosome reaction(GO:0007340)
0.3 17.4 GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity(GO:0051091)
0.3 13.9 GO:1902850 mitotic spindle assembly(GO:0090307) microtubule cytoskeleton organization involved in mitosis(GO:1902850)
0.3 18.6 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.3 17.5 GO:0046928 regulation of neurotransmitter secretion(GO:0046928)
0.3 15.4 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.3 10.6 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.3 0.9 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.3 22.0 GO:0090263 positive regulation of canonical Wnt signaling pathway(GO:0090263)
0.3 11.1 GO:0046330 positive regulation of JNK cascade(GO:0046330)
0.3 2.3 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.3 3.5 GO:0046085 adenosine metabolic process(GO:0046085)
0.3 41.6 GO:0071805 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.2 2.7 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.2 16.9 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.2 9.3 GO:0010675 regulation of cellular carbohydrate metabolic process(GO:0010675) regulation of glucose metabolic process(GO:0010906)
0.2 14.0 GO:0043044 ATP-dependent chromatin remodeling(GO:0043044)
0.2 11.0 GO:0007131 reciprocal meiotic recombination(GO:0007131)
0.2 14.3 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.2 3.7 GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
0.2 0.6 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.2 25.9 GO:0007018 microtubule-based movement(GO:0007018)
0.2 2.0 GO:0015886 heme transport(GO:0015886) iron coordination entity transport(GO:1901678)
0.2 0.8 GO:0090386 phagosome maturation involved in apoptotic cell clearance(GO:0090386) phagolysosome assembly involved in apoptotic cell clearance(GO:0090387)
0.2 22.9 GO:0051260 protein homooligomerization(GO:0051260)
0.2 1.7 GO:1902868 positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868)
0.2 12.4 GO:0007249 I-kappaB kinase/NF-kappaB signaling(GO:0007249)
0.2 19.2 GO:0008285 negative regulation of cell proliferation(GO:0008285)
0.2 3.2 GO:0002027 regulation of heart rate(GO:0002027)
0.1 1.3 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.1 6.6 GO:0006986 response to unfolded protein(GO:0006986)
0.1 11.0 GO:0022900 electron transport chain(GO:0022900)
0.1 6.7 GO:0051781 positive regulation of cell division(GO:0051781)
0.1 1.1 GO:0001516 prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457)
0.1 6.0 GO:0001764 neuron migration(GO:0001764)
0.1 6.0 GO:0043113 receptor clustering(GO:0043113)
0.1 1.9 GO:2000050 regulation of non-canonical Wnt signaling pathway(GO:2000050)
0.1 6.2 GO:0099643 neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643)
0.1 8.2 GO:0061640 cytoskeleton-dependent cytokinesis(GO:0061640)
0.1 10.1 GO:0017157 regulation of exocytosis(GO:0017157)
0.1 1.5 GO:0015780 nucleotide-sugar transport(GO:0015780) pyrimidine nucleotide-sugar transport(GO:0015781) pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.1 7.3 GO:0030042 actin filament depolymerization(GO:0030042)
0.1 2.5 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.1 11.1 GO:0007160 cell-matrix adhesion(GO:0007160)
0.1 12.4 GO:0043066 negative regulation of apoptotic process(GO:0043066)
0.1 0.2 GO:0007008 outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.1 6.4 GO:0032886 regulation of microtubule-based process(GO:0032886) regulation of microtubule cytoskeleton organization(GO:0070507)
0.1 1.2 GO:2000785 regulation of autophagosome assembly(GO:2000785)
0.1 0.7 GO:0007398 ectoderm development(GO:0007398)
0.1 5.0 GO:0030865 cortical cytoskeleton organization(GO:0030865)
0.1 2.7 GO:0008593 regulation of Notch signaling pathway(GO:0008593)
0.1 2.4 GO:0007098 centrosome cycle(GO:0007098)
0.1 4.0 GO:1902593 protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744) single-organism nuclear import(GO:1902593)
0.1 0.7 GO:0035094 response to nicotine(GO:0035094) response to alkaloid(GO:0043279)
0.1 8.8 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 0.8 GO:0001556 oocyte maturation(GO:0001556)
0.0 0.2 GO:0051645 Golgi localization(GO:0051645) maintenance of centrosome location(GO:0051661)
0.0 2.6 GO:1902600 hydrogen ion transmembrane transport(GO:1902600)
0.0 0.2 GO:0007624 ultradian rhythm(GO:0007624)
0.0 0.1 GO:0060823 canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060823) regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060827)
0.0 1.3 GO:0032543 mitochondrial translation(GO:0032543)
0.0 1.5 GO:0001946 lymphangiogenesis(GO:0001946)
0.0 0.3 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0 2.7 GO:0010506 regulation of autophagy(GO:0010506)
0.0 7.7 GO:0000278 mitotic cell cycle(GO:0000278)
0.0 11.7 GO:0006886 intracellular protein transport(GO:0006886)
0.0 2.7 GO:0009116 nucleoside metabolic process(GO:0009116)
0.0 0.3 GO:0051262 protein tetramerization(GO:0051262)
0.0 0.2 GO:0014846 vascular endothelial growth factor production(GO:0010573) regulation of vascular endothelial growth factor production(GO:0010574) positive regulation of vascular endothelial growth factor production(GO:0010575) esophagus smooth muscle contraction(GO:0014846) glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
32.0 95.9 GO:0001534 radial spoke(GO:0001534)
13.5 54.2 GO:0043073 germ cell nucleus(GO:0043073)
8.5 102.4 GO:0036157 outer dynein arm(GO:0036157)
6.4 58.0 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
5.8 23.3 GO:0097255 R2TP complex(GO:0097255)
5.6 66.6 GO:1990246 uniplex complex(GO:1990246)
5.2 382.2 GO:0031514 motile cilium(GO:0031514)
4.9 34.1 GO:0005858 axonemal dynein complex(GO:0005858)
4.6 50.7 GO:0030992 intraciliary transport particle B(GO:0030992)
4.2 163.3 GO:0005930 axoneme(GO:0005930)
4.1 32.7 GO:0034451 centriolar satellite(GO:0034451)
3.5 21.1 GO:0008385 IkappaB kinase complex(GO:0008385)
3.5 24.5 GO:0097223 sperm part(GO:0097223)
2.8 13.9 GO:0005818 astral microtubule(GO:0000235) aster(GO:0005818)
2.6 162.2 GO:0036064 ciliary basal body(GO:0036064)
2.3 27.6 GO:0036038 MKS complex(GO:0036038)
1.8 31.5 GO:0048188 Set1C/COMPASS complex(GO:0048188)
1.7 11.8 GO:1990130 Iml1 complex(GO:1990130)
1.6 11.1 GO:0030877 beta-catenin destruction complex(GO:0030877)
1.5 6.0 GO:0001405 presequence translocase-associated import motor(GO:0001405)
1.4 20.1 GO:0002178 palmitoyltransferase complex(GO:0002178)
1.3 15.2 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
1.2 18.6 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
1.1 213.7 GO:0005929 cilium(GO:0005929)
1.1 12.4 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.9 22.6 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.8 38.5 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.8 13.6 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.7 11.8 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.6 4.8 GO:0001772 immunological synapse(GO:0001772)
0.6 27.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.5 3.2 GO:0033181 plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
0.5 68.5 GO:0005802 trans-Golgi network(GO:0005802)
0.5 57.9 GO:0030658 transport vesicle membrane(GO:0030658)
0.5 46.5 GO:0005581 collagen trimer(GO:0005581)
0.5 12.3 GO:0043195 terminal bouton(GO:0043195)
0.4 20.2 GO:0031941 filamentous actin(GO:0031941)
0.4 13.3 GO:0099569 presynaptic cytoskeleton(GO:0099569)
0.4 8.4 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.3 1.7 GO:1990923 PET complex(GO:1990923)
0.3 2.3 GO:0030892 nuclear cohesin complex(GO:0000798) mitotic cohesin complex(GO:0030892) nuclear mitotic cohesin complex(GO:0034990) nuclear meiotic cohesin complex(GO:0034991)
0.3 3.8 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.3 38.3 GO:0043025 neuronal cell body(GO:0043025)
0.3 16.3 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.3 5.3 GO:0030057 desmosome(GO:0030057)
0.3 6.2 GO:0048786 presynaptic active zone(GO:0048786)
0.3 78.9 GO:0005874 microtubule(GO:0005874)
0.2 22.1 GO:0016323 basolateral plasma membrane(GO:0016323)
0.2 8.9 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.2 13.7 GO:0001726 ruffle(GO:0001726)
0.2 2.2 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.2 1.6 GO:0090533 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.1 9.0 GO:0022626 cytosolic large ribosomal subunit(GO:0022625) cytosolic ribosome(GO:0022626)
0.1 15.5 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 13.1 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.1 5.1 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 93.6 GO:0005829 cytosol(GO:0005829)
0.1 4.0 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 536.6 GO:0005737 cytoplasm(GO:0005737)
0.1 9.3 GO:0005813 centrosome(GO:0005813)
0.1 4.1 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.1 537.4 GO:0005634 nucleus(GO:0005634)
0.1 0.6 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 9.0 GO:0045202 synapse(GO:0045202)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
15.8 47.3 GO:0000293 ferric-chelate reductase activity(GO:0000293)
10.8 43.4 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
7.1 35.4 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
6.9 130.3 GO:0045504 dynein heavy chain binding(GO:0045504)
6.5 58.2 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
5.7 74.7 GO:0004017 adenylate kinase activity(GO:0004017)
5.3 21.1 GO:0008384 IkappaB kinase activity(GO:0008384)
4.3 12.8 GO:0032027 myosin light chain binding(GO:0032027)
3.9 27.5 GO:0001727 lipid kinase activity(GO:0001727)
3.7 22.1 GO:0008502 melatonin receptor activity(GO:0008502)
3.2 58.0 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
2.7 67.4 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
2.6 33.3 GO:0070840 dynein complex binding(GO:0070840)
2.5 80.3 GO:0045505 dynein intermediate chain binding(GO:0045505)
1.9 15.5 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
1.9 807.2 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
1.9 26.4 GO:0070740 protein-glutamic acid ligase activity(GO:0070739) tubulin-glutamic acid ligase activity(GO:0070740)
1.6 12.8 GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485)
1.5 56.5 GO:0051087 chaperone binding(GO:0051087)
1.5 22.2 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
1.5 39.2 GO:0004697 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
1.4 39.1 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
1.4 14.2 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
1.4 16.7 GO:0016500 protein-hormone receptor activity(GO:0016500)
1.3 43.7 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
1.2 7.4 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
1.2 71.9 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
1.2 8.1 GO:0098809 nitrite reductase activity(GO:0098809)
1.1 12.6 GO:0017128 phospholipid scramblase activity(GO:0017128)
1.1 19.2 GO:0005080 protein kinase C binding(GO:0005080)
1.1 20.2 GO:0051393 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
1.0 934.6 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
1.0 14.9 GO:0038191 neuropilin binding(GO:0038191)
1.0 49.3 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
1.0 16.3 GO:0008417 fucosyltransferase activity(GO:0008417)
1.0 4.8 GO:0019865 IgE binding(GO:0019863) immunoglobulin binding(GO:0019865)
0.9 8.5 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.9 9.4 GO:0008172 S-methyltransferase activity(GO:0008172)
0.9 4.7 GO:0030298 receptor signaling protein tyrosine kinase activator activity(GO:0030298)
0.9 8.9 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.9 35.0 GO:0017075 syntaxin-1 binding(GO:0017075)
0.7 13.8 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.7 11.5 GO:0031386 protein tag(GO:0031386)
0.7 17.3 GO:0017080 sodium channel regulator activity(GO:0017080)
0.7 8.2 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.7 17.7 GO:0042043 neurexin family protein binding(GO:0042043)
0.7 7.5 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.6 13.6 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.6 6.8 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.5 15.2 GO:0016208 AMP binding(GO:0016208)
0.5 13.6 GO:0004623 phospholipase A2 activity(GO:0004623)
0.5 27.5 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.5 67.3 GO:0005516 calmodulin binding(GO:0005516)
0.5 3.2 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.5 21.2 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.5 4.0 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.5 6.3 GO:0005222 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.5 57.4 GO:0036459 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.5 3.2 GO:0016880 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.4 7.5 GO:0001671 ATPase activator activity(GO:0001671)
0.4 20.3 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.4 5.7 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.4 3.4 GO:0001222 transcription corepressor binding(GO:0001222)
0.4 32.3 GO:0008080 N-acetyltransferase activity(GO:0008080)
0.4 1.8 GO:0039706 co-receptor binding(GO:0039706)
0.4 54.7 GO:0003713 transcription coactivator activity(GO:0003713)
0.4 28.7 GO:0016651 oxidoreductase activity, acting on NAD(P)H(GO:0016651)
0.3 31.8 GO:0003697 single-stranded DNA binding(GO:0003697)
0.3 135.6 GO:0003924 GTPase activity(GO:0003924)
0.3 1.6 GO:0005119 smoothened binding(GO:0005119)
0.3 41.9 GO:0003714 transcription corepressor activity(GO:0003714)
0.3 5.6 GO:0022841 leak channel activity(GO:0022840) potassium ion leak channel activity(GO:0022841) narrow pore channel activity(GO:0022842)
0.3 26.0 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.3 4.6 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.3 2.7 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.3 3.8 GO:0008327 methyl-CpG binding(GO:0008327)
0.2 5.0 GO:0003785 actin monomer binding(GO:0003785)
0.2 2.0 GO:0015232 heme transporter activity(GO:0015232)
0.2 39.9 GO:0042393 histone binding(GO:0042393)
0.2 10.4 GO:0008013 beta-catenin binding(GO:0008013)
0.2 10.6 GO:0008376 acetylgalactosaminyltransferase activity(GO:0008376)
0.2 0.9 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.2 29.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.2 34.6 GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626) ATPase activity, coupled to movement of substances(GO:0043492)
0.2 1.7 GO:0034584 piRNA binding(GO:0034584)
0.2 4.4 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.2 3.8 GO:0019894 kinesin binding(GO:0019894)
0.2 3.2 GO:0030552 cAMP binding(GO:0030552)
0.2 1.6 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.2 1.7 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.2 3.5 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.2 1.7 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.2 7.3 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.1 19.8 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.1 32.7 GO:0030246 carbohydrate binding(GO:0030246)
0.1 25.3 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 5.2 GO:0044325 ion channel binding(GO:0044325)
0.1 6.7 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 1.4 GO:0030165 PDZ domain binding(GO:0030165)
0.1 2.2 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 19.6 GO:0016887 ATPase activity(GO:0016887)
0.1 6.0 GO:0045296 cadherin binding(GO:0045296)
0.1 1.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 10.2 GO:0004866 endopeptidase inhibitor activity(GO:0004866)
0.1 1.5 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 1.3 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 28.6 GO:0003779 actin binding(GO:0003779)
0.0 3.7 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 1.2 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 1.5 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.9 GO:0008483 transaminase activity(GO:0008483)
0.0 1.5 GO:0005507 copper ion binding(GO:0005507)
0.0 2.5 GO:0008134 transcription factor binding(GO:0008134)
0.0 2.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.2 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 36.1 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
1.2 21.1 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
1.1 39.2 ST GA13 PATHWAY G alpha 13 Pathway
1.0 36.0 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.9 52.6 PID NOTCH PATHWAY Notch signaling pathway
0.8 16.7 PID ARF6 PATHWAY Arf6 signaling events
0.7 7.5 ST GA12 PATHWAY G alpha 12 Pathway
0.5 6.0 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.5 15.2 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.2 8.6 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.2 26.1 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.1 2.8 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 2.6 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.1 10.5 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.1 PID CDC42 PATHWAY CDC42 signaling events
0.0 1.5 PID ILK PATHWAY Integrin-linked kinase signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 32.6 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
2.5 15.2 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
2.1 43.4 REACTOME GLYCOLYSIS Genes involved in Glycolysis
2.0 41.4 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
1.9 31.1 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
1.9 16.7 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
1.4 39.2 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
1.2 12.4 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
1.0 34.2 REACTOME G1 PHASE Genes involved in G1 Phase
0.8 13.6 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.5 4.9 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.4 6.1 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.4 5.7 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.4 4.6 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.3 16.4 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.3 11.8 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.3 11.0 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.2 5.0 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.1 1.3 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 6.2 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 6.2 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.1 9.0 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.1 0.9 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 1.7 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 2.6 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation