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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for rfx7a+rfx7b
Z-value: 5.12
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Transcription factors associated with rfx7a+rfx7b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| rfx7a | dr11_v1_chr7_+_34506937_34506937 | 0.44 | 6.9e-02 | Click! |
| rfx7b | dr11_v1_chr25_+_388258_388258 | -0.07 | 7.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_+_515181 Show fit | 40.79 |
ENSDART00000171374
|
si:ch73-379f7.5 |
|
| chr18_+_2168695 Show fit | 29.96 |
ENSDART00000165855
|
dynein axonemal assembly factor 4 |
|
| chr22_+_3223489 Show fit | 29.42 |
ENSDART00000082011
|
lens intrinsic membrane protein 2.2 |
|
| chr25_+_1035656 Show fit | 20.52 |
ENSDART00000179843
ENSDART00000168637 |
si:ch211-284k5.2 |
|
| chr25_+_21895182 Show fit | 20.11 |
ENSDART00000152075
|
si:ch211-147k9.8 |
|
| chr20_-_3915770 Show fit | 19.85 |
ENSDART00000159322
|
si:ch73-111k22.3 |
|
| chr2_+_7075220 Show fit | 19.68 |
ENSDART00000022963
|
cell division cycle 14Aa |
|
| chr14_+_6954579 Show fit | 19.15 |
ENSDART00000060998
|
NME/NM23 family member 5 |
|
| chr4_+_15819728 Show fit | 18.95 |
ENSDART00000101613
|
leucine-rich repeats and guanylate kinase domain containing |
|
| chr25_-_16755340 Show fit | 18.08 |
ENSDART00000124729
ENSDART00000110859 |
RIB43A domain with coiled-coils 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of rfx7a+rfx7b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 136.1 | GO:0006397 | mRNA processing(GO:0006397) |
| 0.2 | 52.6 | GO:0060271 | cilium morphogenesis(GO:0060271) |
| 1.9 | 37.8 | GO:0060287 | epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287) |
| 0.1 | 33.1 | GO:0060548 | negative regulation of cell death(GO:0060548) |
| 0.4 | 30.7 | GO:0009142 | nucleoside triphosphate biosynthetic process(GO:0009142) |
| 10.0 | 30.0 | GO:0036159 | inner dynein arm assembly(GO:0036159) |
| 3.7 | 29.4 | GO:0048240 | sperm capacitation(GO:0048240) |
| 1.5 | 26.5 | GO:0018095 | protein polyglutamylation(GO:0018095) |
| 3.1 | 25.1 | GO:0003352 | regulation of cilium movement(GO:0003352) |
| 0.6 | 24.1 | GO:0046883 | regulation of hormone secretion(GO:0046883) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 104.3 | GO:0031514 | motile cilium(GO:0031514) |
| 0.0 | 89.9 | GO:0005634 | nucleus(GO:0005634) |
| 1.1 | 48.8 | GO:0030286 | dynein complex(GO:0030286) |
| 2.0 | 36.4 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.2 | 28.7 | GO:0005813 | centrosome(GO:0005813) |
| 0.2 | 27.8 | GO:0005929 | cilium(GO:0005929) |
| 0.8 | 27.3 | GO:0005930 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
| 0.4 | 26.2 | GO:0005814 | centriole(GO:0005814) |
| 3.3 | 19.7 | GO:1902636 | kinociliary basal body(GO:1902636) |
| 0.2 | 19.0 | GO:0055037 | recycling endosome(GO:0055037) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 167.5 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 1.4 | 45.4 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
| 0.0 | 33.3 | GO:0000976 | transcription regulatory region sequence-specific DNA binding(GO:0000976) |
| 0.1 | 32.5 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.0 | 32.4 | GO:0004672 | protein kinase activity(GO:0004672) |
| 6.3 | 31.6 | GO:0004127 | cytidylate kinase activity(GO:0004127) |
| 5.0 | 30.0 | GO:0030331 | estrogen receptor binding(GO:0030331) |
| 0.4 | 29.4 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.1 | 26.9 | GO:0015631 | tubulin binding(GO:0015631) |
| 0.3 | 25.3 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 8.6 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.2 | 7.9 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 2.3 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 1.4 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.0 | 1.3 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 0.4 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 10.2 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 1.7 | 8.6 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.1 | 5.8 | REACTOME POTASSIUM CHANNELS | Genes involved in Potassium Channels |
| 0.4 | 4.5 | REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS | Genes involved in Membrane binding and targetting of GAG proteins |
| 0.1 | 3.2 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.2 | 2.9 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.2 | 2.5 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.1 | 1.5 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.1 | 1.4 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.1 | 1.4 | REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS | Genes involved in Regulation of Water Balance by Renal Aquaporins |