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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for rfx7a+rfx7b

Z-value: 5.12

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Transcription factors associated with rfx7a+rfx7b

Gene Symbol Gene ID Gene Info
rfx7a
ENSDARG00000077237 regulatory factor X7a
rfx7b
ENSDARG00000103691 regulatory factor X7b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
rfx7adr11_v1_chr7_+_34506937_345069370.446.9e-02Click!
rfx7bdr11_v1_chr25_+_388258_388258-0.077.9e-01Click!

Activity profile of rfx7a+rfx7b motif

Sorted Z-values of rfx7a+rfx7b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_515181 40.79 ENSDART00000171374
CACNA1I (1 of many)
si:ch73-379f7.5
chr18_+_2168695 29.96 ENSDART00000165855
dnaaf4
dynein axonemal assembly factor 4
chr22_+_3223489 29.42 ENSDART00000082011
lim2.2
lens intrinsic membrane protein 2.2
chr25_+_1035656 20.52 ENSDART00000179843
ENSDART00000168637
si:ch211-284k5.2
si:ch211-284k5.2
chr25_+_21895182 20.11 ENSDART00000152075
si:ch211-147k9.8
si:ch211-147k9.8
chr20_-_3915770 19.85 ENSDART00000159322
si:ch73-111k22.3
si:ch73-111k22.3
chr2_+_7075220 19.68 ENSDART00000022963
cdc14aa
cell division cycle 14Aa
chr14_+_6954579 19.15 ENSDART00000060998
nme5
NME/NM23 family member 5
chr4_+_15819728 18.95 ENSDART00000101613
lrguk
leucine-rich repeats and guanylate kinase domain containing
chr25_-_16755340 18.08 ENSDART00000124729
ENSDART00000110859
ribc2
RIB43A domain with coiled-coils 2
chr5_-_57920600 17.96 ENSDART00000132376
si:dkey-27p23.3
si:dkey-27p23.3
chr1_-_6225285 17.81 ENSDART00000141653
mdh1b
malate dehydrogenase 1B, NAD (soluble)
chr24_+_22021675 17.43 ENSDART00000081234
ropn1l
rhophilin associated tail protein 1-like
chr20_+_33519435 17.03 ENSDART00000061829
drc1
dynein regulatory complex subunit 1 homolog (Chlamydomonas)
chr17_-_18888959 15.85 ENSDART00000080029
ak7b
adenylate kinase 7b
chr10_-_17231917 15.74 ENSDART00000038577
rab36
RAB36, member RAS oncogene family
chr20_-_4766645 15.73 ENSDART00000147071
ENSDART00000152398
ak7a
adenylate kinase 7a
chr7_+_38395197 15.33 ENSDART00000138669
cep89
centrosomal protein 89
chr20_+_21022641 15.31 ENSDART00000152561
ENSDART00000141591
si:dkey-219e20.2
si:dkey-219e20.2
chr19_+_27589201 15.05 ENSDART00000182060
si:dkeyp-46h3.1
si:dkeyp-46h3.1
chr23_+_37090889 14.87 ENSDART00000074406
ubxn10
UBX domain protein 10
chr9_+_52411530 14.75 ENSDART00000163684
nme8
NME/NM23 family member 8
chr17_-_33716688 14.48 ENSDART00000043651
dnal1
dynein, axonemal, light chain 1
chr6_+_18251140 14.46 ENSDART00000169752
ccdc40
coiled-coil domain containing 40
chr17_-_24684687 14.40 ENSDART00000105457
morn2
MORN repeat containing 2
chr6_+_12853655 14.24 ENSDART00000156341
fam117ba
family with sequence similarity 117, member Ba
chr10_-_17232372 14.20 ENSDART00000135679
rab36
RAB36, member RAS oncogene family
chr1_+_22002649 14.10 ENSDART00000141317
dnah6
dynein, axonemal, heavy chain 6
chr11_-_12232929 14.02 ENSDART00000127611
si:ch211-156l18.4
si:ch211-156l18.4
chr21_-_29940453 13.98 ENSDART00000182862
CU104716.1

chr5_+_39563301 13.85 ENSDART00000131245
ENSDART00000097872
si:ch211-57h10.1
si:ch211-57h10.1
chr17_+_27545183 13.77 ENSDART00000129392
pacrg
PARK2 co-regulated
chr17_+_31592191 13.40 ENSDART00000153765
si:dkey-13p1.3
si:dkey-13p1.3
chr1_+_22003173 13.38 ENSDART00000054388
dnah6
dynein, axonemal, heavy chain 6
chr12_-_11649690 13.37 ENSDART00000149713
btbd16
BTB (POZ) domain containing 16
chr6_-_40842768 13.27 ENSDART00000076160
mustn1a
musculoskeletal, embryonic nuclear protein 1a
chr21_-_29990574 13.25 ENSDART00000185800
si:ch73-190f9.4
si:ch73-190f9.4
chr21_-_29735366 13.19 ENSDART00000181668
CR847571.2

chr21_-_29838117 13.06 ENSDART00000160727
CR762480.1

chr17_+_11500628 13.03 ENSDART00000155660
efcab2
EF-hand calcium binding domain 2
chr13_+_24717880 12.93 ENSDART00000147713
cfap43
cilia and flagella associated protein 43
chr15_+_22267847 12.86 ENSDART00000110665
spa17
sperm autoantigenic protein 17
chr21_-_29991098 12.75 ENSDART00000155772
si:ch73-190f9.4
si:ch73-190f9.4
chr19_+_9091673 12.72 ENSDART00000052898
si:ch211-81a5.5
si:ch211-81a5.5
chr2_-_58085444 12.56 ENSDART00000166395
fcer1gl
Fc receptor, IgE, high affinity I, gamma polypeptide like
chr13_-_36703164 12.49 ENSDART00000044357
cdkl1
cyclin-dependent kinase-like 1 (CDC2-related kinase)
chr23_+_45538932 12.24 ENSDART00000135602
si:ch73-290k24.6
si:ch73-290k24.6
chr11_-_12417952 12.18 ENSDART00000135694
si:dkey-27d5.9
si:dkey-27d5.9
chr13_+_33117528 12.11 ENSDART00000085719
si:ch211-10a23.2
si:ch211-10a23.2
chr17_-_10315644 12.02 ENSDART00000168572
ttc6
tetratricopeptide repeat domain 6
chr24_+_22022109 11.94 ENSDART00000133686
ropn1l
rhophilin associated tail protein 1-like
chr11_-_12717004 11.85 ENSDART00000122020
si:ch211-209f22.3
si:ch211-209f22.3
chr21_-_29416966 11.61 ENSDART00000162575
zgc:171310
zgc:171310
chr25_-_28638052 11.60 ENSDART00000138918
ENSDART00000135247
ENSDART00000114662
ENSDART00000157493
ENSDART00000137677
agbl2
ATP/GTP binding protein-like 2
chr21_-_29295713 11.59 ENSDART00000170081
CR318595.1

chr11_-_12512122 11.56 ENSDART00000145338
si:dkey-27d5.3
si:dkey-27d5.3
chr22_+_25049563 11.54 ENSDART00000078173
dzank1
double zinc ribbon and ankyrin repeat domains 1
chr3_+_24458899 11.50 ENSDART00000156655
cbx6b
chromobox homolog 6b
chr9_+_48219111 11.47 ENSDART00000111225
ENSDART00000145972
ccdc173
coiled-coil domain containing 173
chr17_-_48805159 11.41 ENSDART00000103662
kif6
kinesin family member 6
chr11_+_11374021 11.31 ENSDART00000170806
si:dkey-23f9.8
si:dkey-23f9.8
chr11_-_12437234 11.07 ENSDART00000169324
zgc:174355
zgc:174355
chr6_-_19683406 11.06 ENSDART00000158041
cfap52
cilia and flagella associated protein 52
chr11_-_34720629 11.06 ENSDART00000162066
ENSDART00000161471
dnah1
dynein, axonemal, heavy chain 1
chr11_-_12379541 10.95 ENSDART00000171717
zgc:174353
zgc:174353
chr21_-_29689141 10.81 ENSDART00000100876
CR847571.1

chr21_-_29364166 10.73 ENSDART00000188602
BX537120.3

chr11_+_11387509 10.59 ENSDART00000159578
si:dkey-23f9.9
si:dkey-23f9.9
chr20_-_12642685 10.47 ENSDART00000173257
si:dkey-97l20.6
si:dkey-97l20.6
chr24_-_37472727 10.47 ENSDART00000134152
cluap1
clusterin associated protein 1
chr7_-_40738774 10.34 ENSDART00000084179
rnf32
ring finger protein 32
chr20_-_7080427 10.32 ENSDART00000140166
ENSDART00000023677
si:ch211-121a2.2
si:ch211-121a2.2
chr11_-_30352333 10.16 ENSDART00000030794
tmem169a
transmembrane protein 169a
chr4_-_78026285 10.16 ENSDART00000168273
CCT2
chaperonin containing TCP1 subunit 2
chr24_-_17067284 10.14 ENSDART00000111237
armc3
armadillo repeat containing 3
chr11_+_11347031 10.07 ENSDART00000172429
ENSDART00000193128
si:dkey-23f9.6
si:dkey-23f9.6
chr13_+_24679674 10.07 ENSDART00000033090
ENSDART00000139854
zgc:66426
zgc:66426
chr22_-_25033105 9.98 ENSDART00000124220
nptxrb
neuronal pentraxin receptor b
chr17_+_21817859 9.97 ENSDART00000143832
ENSDART00000141462
ikzf5
IKAROS family zinc finger 5
chr2_-_42960353 9.96 ENSDART00000098303
oc90
otoconin 90
chr11_+_11430552 9.92 ENSDART00000160339
si:dkey-23f9.11
si:dkey-23f9.11
chr12_+_17620067 9.81 ENSDART00000073599
rsph10b
radial spoke head 10 homolog B
chr15_-_23206562 9.80 ENSDART00000110360
ccdc153
coiled-coil domain containing 153
chr25_-_10571078 9.72 ENSDART00000153898
si:ch211-107e6.5
si:ch211-107e6.5
chr5_+_32260502 9.43 ENSDART00000149020
si:ch211-158m24.12
si:ch211-158m24.12
chr4_+_9609905 9.38 ENSDART00000142284
ENSDART00000150687
meig1
meiosis/spermiogenesis associated 1
chr7_-_22981796 9.19 ENSDART00000167565
si:dkey-171c9.3
si:dkey-171c9.3
chr2_-_1569250 9.15 ENSDART00000167202
dab1b
Dab, reelin signal transducer, homolog 1b (Drosophila)
chr11_-_12364122 9.08 ENSDART00000170129
zgc:174353
zgc:174353
chr21_-_29533723 9.01 ENSDART00000193554
BX537120.2

chr11_+_11360641 8.94 ENSDART00000159765
si:dkey-23f9.7
si:dkey-23f9.7
chr23_+_12134839 8.69 ENSDART00000128551
ENSDART00000141204
ttll9
tubulin tyrosine ligase-like family, member 9
chr4_-_12795436 8.60 ENSDART00000131026
ENSDART00000075127
b2m
beta-2-microglobulin
chr19_-_10648523 8.55 ENSDART00000059358
tekt2
tektin 2 (testicular)
chr3_-_31619463 8.39 ENSDART00000124559
moto
minamoto
chr11_-_12394682 8.36 ENSDART00000172447
si:dkey-27d5.10
si:dkey-27d5.10
chr20_-_32007209 8.30 ENSDART00000021575
adgb
androglobin
chr11_-_12219829 8.10 ENSDART00000168025
ENSDART00000112677
ENSDART00000108681
si:ch211-156l18.6
si:ch211-156l18.6
chr3_+_60716904 8.08 ENSDART00000168280
foxj1a
forkhead box J1a
chr17_+_23937262 8.04 ENSDART00000113276
si:ch211-189k9.2
si:ch211-189k9.2
chr20_-_29475172 8.00 ENSDART00000183164
scg5
secretogranin V
chr13_+_233482 7.99 ENSDART00000102511
cfap36
cilia and flagella associated protein 36
chr20_-_29474859 7.92 ENSDART00000152906
ENSDART00000045249
scg5
secretogranin V
chr12_+_19188542 7.89 ENSDART00000134726
ENSDART00000148011
ENSDART00000109541
cby1
chibby homolog 1 (Drosophila)
chr13_-_48764180 7.67 ENSDART00000167157
si:ch1073-266p11.2
si:ch1073-266p11.2
chr11_+_37652870 7.63 ENSDART00000129918
kif17
kinesin family member 17
chr13_-_11971148 7.62 ENSDART00000066230
ENSDART00000185614
ARL3 (1 of many)
zgc:110197
chr12_+_7445595 7.49 ENSDART00000103536
ENSDART00000152524
phyhiplb
phytanoyl-CoA 2-hydroxylase interacting protein-like b
chr14_-_30724165 7.48 ENSDART00000020936
fibpa
fibroblast growth factor (acidic) intracellular binding protein a
chr20_+_2139436 7.45 ENSDART00000155311
l3mbtl3
l(3)mbt-like 3 (Drosophila)
chr10_+_14499201 7.35 ENSDART00000064901
katnal2
katanin p60 subunit A-like 2
chr3_-_60175470 7.28 ENSDART00000156597
si:ch73-364h19.1
si:ch73-364h19.1
chr5_-_52569014 7.21 ENSDART00000165616
mamdc2a
MAM domain containing 2a
chr13_-_29406534 7.18 ENSDART00000100877
zgc:153142
zgc:153142
chr19_-_47526737 7.16 ENSDART00000186636
scg5
secretogranin V
chr6_+_52350443 7.14 ENSDART00000151612
ENSDART00000151349
si:ch211-239j9.1
si:ch211-239j9.1
chr7_+_8670398 7.04 ENSDART00000164195
si:ch211-1o7.2
si:ch211-1o7.2
chr11_-_12379359 6.88 ENSDART00000187551
zgc:174353
zgc:174353
chr17_-_46933567 6.76 ENSDART00000157274
pimr25
Pim proto-oncogene, serine/threonine kinase, related 25
chr4_+_77919987 6.71 ENSDART00000150171
ttll1
tubulin tyrosine ligase-like family, member 1
chr11_-_12232769 6.63 ENSDART00000180116
si:ch211-156l18.4
si:ch211-156l18.4
chr1_+_8662530 6.63 ENSDART00000054989
fscn1b
fascin actin-bundling protein 1b
chr14_+_35892802 6.60 ENSDART00000135079
zgc:63568
zgc:63568
chr13_-_6218248 6.55 ENSDART00000159052
si:zfos-1056e6.1
si:zfos-1056e6.1
chr22_-_24984733 6.38 ENSDART00000142147
ENSDART00000187284
dnal4b
dynein, axonemal, light chain 4b
chr20_+_46586678 6.36 ENSDART00000014166
ENSDART00000179266
jdp2b
Jun dimerization protein 2b
chr21_+_26726936 6.22 ENSDART00000065392
calm2a
calmodulin 2a (phosphorylase kinase, delta)
chr11_+_11387682 6.18 ENSDART00000192505
si:dkey-23f9.9
si:dkey-23f9.9
chr7_-_28403930 6.16 ENSDART00000076496
stk33
serine/threonine kinase 33
chr7_-_27038488 6.16 ENSDART00000052731
ENSDART00000191382
nucb2a
nucleobindin 2a
chr13_-_3155243 6.05 ENSDART00000139183
ENSDART00000050934
pkdcca
protein kinase domain containing, cytoplasmic a
chr18_+_5618368 5.98 ENSDART00000159945
ulk3
unc-51 like kinase 3
chr5_-_52813442 5.86 ENSDART00000169305
zgc:158260
zgc:158260
chr25_+_25438322 5.81 ENSDART00000150364
LRRC56
si:ch211-103e16.5
chr7_-_24236364 5.80 ENSDART00000010124
slc7a8a
solute carrier family 7 (amino acid transporter light chain, L system), member 8a
chr19_+_46095210 5.74 ENSDART00000159753
stmnd1
stathmin domain containing 1
chr10_-_10864331 5.72 ENSDART00000122657
nrarpa
NOTCH regulated ankyrin repeat protein a
chr19_+_17400283 5.65 ENSDART00000127353
nr1d2b
nuclear receptor subfamily 1, group D, member 2b
chr17_+_21818093 5.51 ENSDART00000125335
ikzf5
IKAROS family zinc finger 5
chr19_-_47527093 5.45 ENSDART00000171379
ENSDART00000171140
ENSDART00000114886
scg5
secretogranin V
chr24_+_12989727 5.42 ENSDART00000126842
ENSDART00000129309
flj11011l
hypothetical protein FLJ11011-like (H. sapiens)
chr17_+_46935061 5.38 ENSDART00000156578
pimr26
Pim proto-oncogene, serine/threonine kinase, related 26
chr6_-_16735402 5.38 ENSDART00000154216
pimr44
Pim proto-oncogene, serine/threonine kinase, related 44
chr10_-_10863936 5.36 ENSDART00000180568
nrarpa
NOTCH regulated ankyrin repeat protein a
chr14_-_1355544 5.34 ENSDART00000060417
cetn4
centrin 4
chr11_-_12530123 5.26 ENSDART00000182651
zgc:174354
zgc:174354
chr25_+_34845115 5.23 ENSDART00000061996
tmem231
transmembrane protein 231
chr16_-_24819860 5.19 ENSDART00000183874
kcnn4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr24_-_36910224 5.15 ENSDART00000079233
dnaaf3l
dynein, axonemal, assembly factor 3 like
chr18_-_21950751 5.13 ENSDART00000043452
tsnaxip1
translin-associated factor X interacting protein 1
chr20_+_30797329 5.07 ENSDART00000145066
nhsl1b
NHS-like 1b
chr1_-_21538673 5.06 ENSDART00000131257
wdr19
WD repeat domain 19
chr20_+_18225329 5.06 ENSDART00000144172
kctd1
potassium channel tetramerization domain containing 1
chr19_+_27479563 5.06 ENSDART00000049368
ENSDART00000185426
atat1
alpha tubulin acetyltransferase 1
chr24_+_26345427 4.99 ENSDART00000089756
lrrc34
leucine rich repeat containing 34
chr7_+_52159028 4.91 ENSDART00000014632
ENSDART00000174042
katnb1
katanin p80 (WD repeat containing) subunit B 1
chr14_+_1351214 4.91 ENSDART00000007091
bbs12
Bardet-Biedl syndrome 12
chr14_+_24283915 4.89 ENSDART00000172868
klhl3
kelch-like family member 3
chr16_-_13388821 4.87 ENSDART00000144062
grin2db
glutamate receptor, ionotropic, N-methyl D-aspartate 2D, b
chr16_-_50203058 4.85 ENSDART00000154570
vsig10l
V-set and immunoglobulin domain containing 10 like
chr3_-_12026741 4.84 ENSDART00000132238
cfap70
cilia and flagella associated protein 70
chr25_+_35942867 4.78 ENSDART00000066985
hsd17b2
hydroxysteroid (17-beta) dehydrogenase 2
chr20_+_591505 4.78 ENSDART00000046438
kcnk2b
potassium channel, subfamily K, member 2b
chr1_-_17675037 4.71 ENSDART00000142689
si:dkey-256e7.5
si:dkey-256e7.5
chr25_-_36248053 4.71 ENSDART00000134928
nfatc3b
nuclear factor of activated T cells 3b
chr19_+_27479838 4.57 ENSDART00000103922
atat1
alpha tubulin acetyltransferase 1
chr4_-_1497384 4.54 ENSDART00000093236
zmp:0000000711
zmp:0000000711
chr7_+_22981909 4.43 ENSDART00000122449
ccnb3
cyclin B3
chr16_+_5901835 4.37 ENSDART00000060519
ulk4
unc-51 like kinase 4
chr25_+_34845469 4.29 ENSDART00000145416
tmem231
transmembrane protein 231
chr25_+_36046287 4.20 ENSDART00000185324
rpgrip1l
RPGRIP1-like
chr21_-_21791098 4.14 ENSDART00000151576
xrra1
X-ray radiation resistance associated 1
chr1_-_21538329 4.13 ENSDART00000182798
ENSDART00000193518
ENSDART00000183873
ENSDART00000183376
wdr19
WD repeat domain 19
chr21_-_2955181 4.09 ENSDART00000158991
ENSDART00000174052
znf971
zinc finger protein 971
chr21_-_12036134 4.04 ENSDART00000031658
tpgs2
tubulin polyglutamylase complex subunit 2
chr1_-_45633955 3.96 ENSDART00000044057
sept3
septin 3
chr22_-_7669624 3.92 ENSDART00000189617
AL929276.2

chr16_+_50006872 3.86 ENSDART00000157100
ube2e2
ubiquitin-conjugating enzyme E2E 2
chr7_-_27037990 3.85 ENSDART00000173561
nucb2a
nucleobindin 2a
chr4_-_71110826 3.82 ENSDART00000167431
si:dkeyp-80d11.1
si:dkeyp-80d11.1
chr16_+_28578648 3.75 ENSDART00000149566
nmt2
N-myristoyltransferase 2
chr3_+_28831450 3.72 ENSDART00000055422
flr
fleer
chr23_-_45539306 3.71 ENSDART00000161913
CU681841.1

chr24_+_26345609 3.63 ENSDART00000186844
lrrc34
leucine rich repeat containing 34
chr14_+_1355857 3.59 ENSDART00000188008
bbs12
Bardet-Biedl syndrome 12
chr13_+_48482256 3.46 ENSDART00000053332
FOXN2 (1 of many)
forkhead box N2
chr11_+_1533097 3.42 ENSDART00000066191
ift52
intraflagellar transport 52 homolog (Chlamydomonas)
chr5_+_24882633 3.39 ENSDART00000111302
rhbdd3
rhomboid domain containing 3
chr19_+_22062202 3.37 ENSDART00000100181
sall3b
spalt-like transcription factor 3b
chr3_+_28831622 3.30 ENSDART00000184130
ENSDART00000191294
flr
fleer
chr17_+_33767890 3.21 ENSDART00000193177
fut8a
fucosyltransferase 8a (alpha (1,6) fucosyltransferase)
chr7_+_22982201 3.19 ENSDART00000134116
ccnb3
cyclin B3
chr15_+_37589698 3.18 ENSDART00000076066
ENSDART00000153894
ENSDART00000156298
lin37
lin-37 DREAM MuvB core complex component
chr9_-_54716363 3.16 ENSDART00000162158
ENSDART00000168430
trappc2
trafficking protein particle complex 2
chr11_+_25328199 3.06 ENSDART00000141478
ENSDART00000112209
fam83d
family with sequence similarity 83, member D
chr10_+_25204626 2.90 ENSDART00000024514
chordc1b
cysteine and histidine-rich domain (CHORD) containing 1b
chr14_-_38827442 2.88 ENSDART00000160000
spdl1
spindle apparatus coiled-coil protein 1
chr11_-_40519886 2.87 ENSDART00000172819
miip
migration and invasion inhibitory protein
chr7_+_52158818 2.83 ENSDART00000174389
katnb1
katanin p80 (WD repeat containing) subunit B 1
chr7_+_22981441 2.78 ENSDART00000182887
ccnb3
cyclin B3

Network of associatons between targets according to the STRING database.

First level regulatory network of rfx7a+rfx7b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
10.0 30.0 GO:0036159 inner dynein arm assembly(GO:0036159)
6.4 19.1 GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902175) negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902176)
3.7 29.4 GO:0048240 sperm capacitation(GO:0048240)
3.6 17.8 GO:0006107 oxaloacetate metabolic process(GO:0006107)
3.1 25.1 GO:0003352 regulation of cilium movement(GO:0003352)
2.9 11.6 GO:0035610 protein side chain deglutamylation(GO:0035610)
2.7 13.3 GO:0035988 chondrocyte proliferation(GO:0035988)
2.6 15.5 GO:0071908 determination of intestine left/right asymmetry(GO:0071908)
2.2 12.9 GO:0007288 sperm axoneme assembly(GO:0007288)
1.9 37.8 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
1.7 19.9 GO:0001881 receptor recycling(GO:0001881)
1.6 4.9 GO:0072156 distal tubule morphogenesis(GO:0072156)
1.5 26.5 GO:0018095 protein polyglutamylation(GO:0018095)
1.4 14.2 GO:0071850 mitotic cell cycle arrest(GO:0071850)
1.2 14.5 GO:0036158 outer dynein arm assembly(GO:0036158)
1.2 8.4 GO:0007141 male meiosis I(GO:0007141)
1.1 9.2 GO:0097476 spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477)
1.1 6.8 GO:2000582 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
1.1 4.5 GO:0018377 N-terminal protein myristoylation(GO:0006499) N-terminal peptidyl-glycine N-myristoylation(GO:0018008) protein myristoylation(GO:0018377)
1.1 7.6 GO:0098935 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937) anterograde dendritic transport of neurotransmitter receptor complex(GO:0098971)
1.1 8.5 GO:0060294 cilium movement involved in cell motility(GO:0060294)
1.0 9.2 GO:0035721 intraciliary retrograde transport(GO:0035721)
1.0 10.0 GO:0032099 negative regulation of response to food(GO:0032096) negative regulation of appetite(GO:0032099)
1.0 7.7 GO:0051013 microtubule severing(GO:0051013)
0.9 11.1 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.9 5.3 GO:0021846 cell proliferation in forebrain(GO:0021846)
0.8 2.5 GO:0046069 cGMP catabolic process(GO:0046069)
0.8 6.4 GO:0031063 regulation of histone deacetylation(GO:0031063)
0.8 7.7 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.7 11.1 GO:0030317 sperm motility(GO:0030317)
0.7 10.0 GO:0032309 icosanoid secretion(GO:0032309) arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.7 8.6 GO:0045824 negative regulation of innate immune response(GO:0045824)
0.6 24.1 GO:0046883 regulation of hormone secretion(GO:0046883)
0.6 5.3 GO:0007080 mitotic metaphase plate congression(GO:0007080)
0.5 8.1 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.5 3.1 GO:0051310 metaphase plate congression(GO:0051310)
0.5 2.0 GO:0007638 mechanosensory behavior(GO:0007638)
0.5 5.1 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.4 5.1 GO:0097475 motor neuron migration(GO:0097475)
0.4 4.2 GO:0046548 retinal rod cell development(GO:0046548)
0.4 1.2 GO:0045218 zonula adherens maintenance(GO:0045218)
0.4 30.7 GO:0009142 nucleoside triphosphate biosynthetic process(GO:0009142)
0.4 1.2 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.4 13.3 GO:0010389 regulation of G2/M transition of mitotic cell cycle(GO:0010389)
0.4 0.7 GO:0036498 IRE1-mediated unfolded protein response(GO:0036498)
0.4 2.1 GO:0036372 opsin transport(GO:0036372)
0.4 1.4 GO:0003245 growth involved in heart morphogenesis(GO:0003241) cardiac chamber ballooning(GO:0003242) cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
0.3 7.7 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.3 4.7 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.3 1.5 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.3 12.9 GO:0003341 cilium movement(GO:0003341)
0.3 11.5 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.3 4.1 GO:0010165 response to X-ray(GO:0010165)
0.3 4.9 GO:0060079 excitatory postsynaptic potential(GO:0060079)
0.2 136.1 GO:0006397 mRNA processing(GO:0006397)
0.2 1.1 GO:0030299 intestinal cholesterol absorption(GO:0030299)
0.2 3.4 GO:0042073 intraciliary transport(GO:0042073)
0.2 3.2 GO:0036065 fucosylation(GO:0036065)
0.2 52.6 GO:0060271 cilium morphogenesis(GO:0060271)
0.2 4.8 GO:0030322 stabilization of membrane potential(GO:0030322)
0.2 6.2 GO:0042770 signal transduction in response to DNA damage(GO:0042770)
0.2 5.7 GO:0007019 microtubule depolymerization(GO:0007019)
0.2 1.9 GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902041) negative regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902042)
0.2 1.4 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.2 4.5 GO:0061512 protein localization to cilium(GO:0061512)
0.2 2.4 GO:0021988 olfactory bulb development(GO:0021772) olfactory lobe development(GO:0021988) synaptic membrane adhesion(GO:0099560)
0.2 3.7 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.2 5.8 GO:0015804 neutral amino acid transport(GO:0015804)
0.2 1.1 GO:0070293 renal absorption(GO:0070293)
0.1 0.4 GO:0009972 cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087)
0.1 3.9 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.1 1.9 GO:1903286 positive regulation of sodium ion transport(GO:0010765) positive regulation of sodium ion transmembrane transport(GO:1902307) regulation of potassium ion import(GO:1903286) positive regulation of potassium ion import(GO:1903288) positive regulation of sodium ion transmembrane transporter activity(GO:2000651)
0.1 11.4 GO:0021510 spinal cord development(GO:0021510)
0.1 6.6 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.1 1.1 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625)
0.1 10.6 GO:0070507 regulation of microtubule cytoskeleton organization(GO:0070507)
0.1 0.5 GO:0002159 desmosome assembly(GO:0002159)
0.1 9.4 GO:0007283 spermatogenesis(GO:0007283)
0.1 2.0 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.1 12.9 GO:0007163 establishment or maintenance of cell polarity(GO:0007163)
0.1 0.6 GO:1902259 regulation of delayed rectifier potassium channel activity(GO:1902259)
0.1 1.6 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.1 1.4 GO:0072114 pronephros morphogenesis(GO:0072114)
0.1 33.1 GO:0060548 negative regulation of cell death(GO:0060548)
0.1 0.8 GO:0006596 polyamine biosynthetic process(GO:0006596)
0.1 0.4 GO:0031061 bulbus arteriosus development(GO:0003232) proepicardium development(GO:0003342) septum transversum development(GO:0003343) negative regulation of histone methylation(GO:0031061)
0.1 2.3 GO:0048538 thymus development(GO:0048538)
0.1 2.5 GO:0072175 epithelial tube formation(GO:0072175)
0.1 1.4 GO:0045839 negative regulation of mitotic nuclear division(GO:0045839)
0.1 4.0 GO:0061640 cytoskeleton-dependent cytokinesis(GO:0061640)
0.0 7.2 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.0 5.1 GO:0051260 protein homooligomerization(GO:0051260)
0.0 1.7 GO:0030490 maturation of SSU-rRNA(GO:0030490)
0.0 1.8 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.0 9.0 GO:0051493 regulation of cytoskeleton organization(GO:0051493)
0.0 8.7 GO:0006470 protein dephosphorylation(GO:0006470)
0.0 0.5 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.0 0.9 GO:0046777 protein autophosphorylation(GO:0046777)
0.0 1.0 GO:0048015 phosphatidylinositol-mediated signaling(GO:0048015)
0.0 0.4 GO:0001935 endothelial cell proliferation(GO:0001935)
0.0 1.4 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 0.9 GO:0009755 hormone-mediated signaling pathway(GO:0009755)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 12.6 GO:0032998 Fc receptor complex(GO:0032997) Fc-epsilon receptor I complex(GO:0032998)
3.3 19.7 GO:1902636 kinociliary basal body(GO:1902636)
3.2 3.2 GO:0017053 transcriptional repressor complex(GO:0017053)
2.6 7.7 GO:0008352 katanin complex(GO:0008352)
2.0 36.4 GO:0030992 intraciliary transport particle B(GO:0030992)
1.6 11.1 GO:0036156 inner dynein arm(GO:0036156)
1.5 104.3 GO:0031514 motile cilium(GO:0031514)
1.4 8.6 GO:0042612 MHC class I protein complex(GO:0042612)
1.1 9.2 GO:0030991 intraciliary transport particle A(GO:0030991)
1.1 48.8 GO:0030286 dynein complex(GO:0030286)
0.9 12.7 GO:0097546 ciliary base(GO:0097546)
0.9 10.7 GO:0097431 mitotic spindle pole(GO:0097431)
0.8 2.5 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.8 27.3 GO:0005930 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.7 11.7 GO:0036038 MKS complex(GO:0036038)
0.4 26.2 GO:0005814 centriole(GO:0005814)
0.4 4.2 GO:0035869 ciliary transition zone(GO:0035869)
0.4 5.3 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.3 4.9 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.2 10.4 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 1.2 GO:0005915 cell-cell adherens junction(GO:0005913) zonula adherens(GO:0005915)
0.2 13.2 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.2 19.0 GO:0055037 recycling endosome(GO:0055037)
0.2 28.7 GO:0005813 centrosome(GO:0005813)
0.2 8.4 GO:0005902 microvillus(GO:0005902)
0.2 4.0 GO:0005940 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.2 27.8 GO:0005929 cilium(GO:0005929)
0.2 1.7 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.2 4.9 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 1.2 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.1 9.2 GO:0005819 spindle(GO:0005819)
0.1 0.9 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.1 3.7 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.1 3.2 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 11.1 GO:0005874 microtubule(GO:0005874)
0.0 2.5 GO:0005815 microtubule organizing center(GO:0005815)
0.0 0.5 GO:0030057 desmosome(GO:0030057)
0.0 2.4 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 0.7 GO:0035861 site of double-strand break(GO:0035861)
0.0 2.0 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 15.1 GO:0043005 neuron projection(GO:0043005)
0.0 5.6 GO:0005667 transcription factor complex(GO:0005667)
0.0 1.4 GO:0016459 myosin complex(GO:0016459)
0.0 89.9 GO:0005634 nucleus(GO:0005634)
0.0 1.1 GO:0005604 basement membrane(GO:0005604)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
6.3 31.6 GO:0004127 cytidylate kinase activity(GO:0004127)
5.0 30.0 GO:0030331 estrogen receptor binding(GO:0030331)
4.2 12.6 GO:0019763 immunoglobulin receptor activity(GO:0019763) IgE receptor activity(GO:0019767)
3.8 19.0 GO:0004385 guanylate kinase activity(GO:0004385)
3.6 17.8 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
2.3 7.0 GO:0070735 protein-glycine ligase activity(GO:0070735) tubulin-glycine ligase activity(GO:0070738)
1.4 45.4 GO:0045505 dynein intermediate chain binding(GO:0045505)
1.2 14.5 GO:0043014 alpha-tubulin binding(GO:0043014)
1.2 4.8 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
1.1 4.5 GO:0004379 glycylpeptide N-tetradecanoyltransferase activity(GO:0004379)
1.1 15.4 GO:0070740 protein-glutamic acid ligase activity(GO:0070739) tubulin-glutamic acid ligase activity(GO:0070740)
0.9 13.8 GO:0030544 Hsp70 protein binding(GO:0030544)
0.8 19.1 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.7 7.4 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.6 5.3 GO:0043515 kinetochore binding(GO:0043515)
0.6 5.2 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.5 12.5 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.5 2.0 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.5 1.8 GO:0004064 arylesterase activity(GO:0004064)
0.4 11.6 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.4 1.2 GO:0070097 delta-catenin binding(GO:0070097)
0.4 10.0 GO:0004623 phospholipase A2 activity(GO:0004623)
0.4 167.5 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.4 1.2 GO:0003875 ADP-ribosylarginine hydrolase activity(GO:0003875)
0.4 29.4 GO:0005212 structural constituent of eye lens(GO:0005212)
0.3 7.5 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.3 4.8 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.3 25.3 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.3 9.2 GO:0051018 protein kinase A binding(GO:0051018)
0.3 8.3 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.3 2.0 GO:0001222 transcription corepressor binding(GO:0001222)
0.2 8.2 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.2 3.7 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.2 4.9 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.2 0.7 GO:0071568 UFM1 transferase activity(GO:0071568)
0.2 12.8 GO:0003777 microtubule motor activity(GO:0003777)
0.2 0.8 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.2 2.5 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.2 3.2 GO:0008417 fucosyltransferase activity(GO:0008417)
0.2 9.6 GO:0061733 peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.2 10.4 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 1.9 GO:0019870 chloride channel inhibitor activity(GO:0019869) potassium channel inhibitor activity(GO:0019870)
0.1 1.7 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 1.4 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1 6.6 GO:0030674 protein binding, bridging(GO:0030674)
0.1 26.9 GO:0015631 tubulin binding(GO:0015631)
0.1 1.1 GO:0004859 phospholipase inhibitor activity(GO:0004859) lipase inhibitor activity(GO:0055102)
0.1 12.9 GO:0005516 calmodulin binding(GO:0005516)
0.1 32.5 GO:0003924 GTPase activity(GO:0003924)
0.1 3.9 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 0.2 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.1 8.9 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879)
0.1 0.4 GO:0004126 cytidine deaminase activity(GO:0004126)
0.1 0.5 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 1.4 GO:0030165 PDZ domain binding(GO:0030165)
0.0 7.5 GO:0042393 histone binding(GO:0042393)
0.0 1.8 GO:0044325 ion channel binding(GO:0044325)
0.0 1.4 GO:0005109 frizzled binding(GO:0005109)
0.0 1.0 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.0 32.4 GO:0004672 protein kinase activity(GO:0004672)
0.0 1.4 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 3.7 GO:0019901 protein kinase binding(GO:0019901)
0.0 1.1 GO:0042562 hormone binding(GO:0042562)
0.0 1.4 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.6 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 14.3 GO:0030234 enzyme regulator activity(GO:0030234)
0.0 33.3 GO:0000976 transcription regulatory region sequence-specific DNA binding(GO:0000976)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 8.6 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.2 7.9 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 1.4 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 1.3 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.4 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 2.3 WNT SIGNALING Genes related to Wnt-mediated signal transduction

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 8.6 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.5 10.2 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.4 4.5 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.2 2.5 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.2 2.9 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.1 3.2 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.1 1.5 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.1 5.8 REACTOME POTASSIUM CHANNELS Genes involved in Potassium Channels
0.1 1.4 REACTOME KINESINS Genes involved in Kinesins
0.1 0.5 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.1 1.4 REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.0 1.4 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.2 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation