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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for rorc

Z-value: 0.23

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Transcription factors associated with rorc

Gene Symbol Gene ID Gene Info
ENSDARG00000087195 RAR-related orphan receptor C

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
rorcdr11_v1_chr16_+_17913936_179139450.213.9e-01Click!

Activity profile of rorc motif

Sorted Z-values of rorc motif

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_70155935 1.23 ENSDART00000165570
regulator of G protein signaling 3a
chr8_+_43340995 0.80 ENSDART00000038566
refilin A
chr8_-_51349429 0.66 ENSDART00000134043
ENSDART00000098282
si:ch211-198o12.4
chr15_-_37829160 0.53 ENSDART00000099425
chymotrypsin-like
chr18_+_7594012 0.50 ENSDART00000062150
zgc:77752
chr5_-_69523816 0.47 ENSDART00000112692
si:ch211-157p22.10
chr22_-_834106 0.42 ENSDART00000105873
cryptochrome circadian clock 4
chr20_-_4738101 0.40 ENSDART00000050201
ENSDART00000152559
ENSDART00000053858
ENSDART00000125620
poly(A) polymerase alpha
chr20_-_14680897 0.35 ENSDART00000063857
ENSDART00000161314
secernin 2
chr4_-_191736 0.33 ENSDART00000169187
ENSDART00000192054
protein tyrosine phosphatase, receptor type, O
chr8_+_26034623 0.32 ENSDART00000004521
ENSDART00000142555
ariadne homolog 2 (Drosophila)
chr3_-_22829710 0.32 ENSDART00000055659
cytochrome b561
chr12_+_31616412 0.32 ENSDART00000124439
carboxypeptidase N, polypeptide 1
chr4_+_17280868 0.27 ENSDART00000145349
branched chain amino-acid transaminase 1, cytosolic
chr21_+_30549512 0.27 ENSDART00000132831
RAB38c, member of RAS oncogene family
chr3_+_59935606 0.25 ENSDART00000154157
Rho GDP dissociation inhibitor (GDI) alpha
chr23_-_36724575 0.24 ENSDART00000159560
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr18_+_22302635 0.23 ENSDART00000141051
capping protein regulator and myosin 1 linker 2
chr18_-_15911394 0.22 ENSDART00000091339
pleckstrin homology domain containing, family G (with RhoGef domain) member 7
chr21_-_5881344 0.22 ENSDART00000009241
ribosomal protein L35
chr24_-_982443 0.22 ENSDART00000063151
N-ethylmaleimide-sensitive factor attachment protein, gamma a
chr16_+_17715243 0.22 ENSDART00000149437
ENSDART00000149596
si:dkey-87o1.2
chr13_+_21768447 0.22 ENSDART00000100941
coiled-coil-helix-coiled-coil-helix domain containing 1
chr5_-_63281395 0.21 ENSDART00000005696
tubulin folding cofactor E-like b
chr19_+_30990815 0.20 ENSDART00000134645
syncoilin, intermediate filament protein
chr20_+_16750177 0.20 ENSDART00000185357
calmodulin 1b
chr9_+_35876927 0.20 ENSDART00000138834
mab-21-like 3
chr5_+_2815021 0.19 ENSDART00000020472
4-hydroxyphenylpyruvate dioxygenase a
chr14_-_25111496 0.19 ENSDART00000158108
si:rp71-1d10.8
chr2_-_37896965 0.19 ENSDART00000129852
hexose-binding lectin 1
chr18_+_36631923 0.18 ENSDART00000098980
zinc finger protein 296
chr12_-_32013125 0.17 ENSDART00000153355
glutamate receptor, ionotropic, N-methyl D-aspartate 2Cb
chr1_-_49498116 0.17 ENSDART00000137357
zgc:175214
chr13_-_1130096 0.16 ENSDART00000010261
partner of NOB1 homolog
chr19_+_4990320 0.16 ENSDART00000147056
zgc:91968
chr7_+_40228422 0.14 ENSDART00000052222
protein tyrosine phosphatase, receptor type, N polypeptide 2
chr25_-_1235457 0.14 ENSDART00000093093
coronin, actin binding protein, 2Bb
chr16_-_27442344 0.14 ENSDART00000027545
endoplasmic reticulum protein 44
chr7_+_65240227 0.13 ENSDART00000168287
beta-carotene oxygenase 1, like
chr19_+_2590182 0.13 ENSDART00000162293
si:ch73-345f18.3
chr8_+_18464235 0.13 ENSDART00000110571
ALK and LTK ligand 1
chr2_+_49864219 0.13 ENSDART00000187744
ribosomal protein L37
chr22_+_26263290 0.12 ENSDART00000184840

chr22_-_11124419 0.12 ENSDART00000149634
ATPase H+ transporting accessory protein 2
chr14_+_17376940 0.12 ENSDART00000054590
ENSDART00000010148
spondin 2b, extracellular matrix protein
chr3_-_5362347 0.12 ENSDART00000187511
tripartite motif containing 35-7
chr2_-_56655769 0.12 ENSDART00000113589
glutathione peroxidase 4b
chr2_+_48282590 0.12 ENSDART00000035338
lysophosphatidic acid receptor 5a
chr25_+_3035384 0.12 ENSDART00000184219
ENSDART00000149360
mannose phosphate isomerase
chr7_-_30227878 0.11 ENSDART00000173514
zinc finger protein 710b
chr19_+_10860485 0.11 ENSDART00000169962
si:ch73-347e22.4
chr20_-_30377221 0.11 ENSDART00000126229
ribosomal protein S7
chr8_+_18463797 0.11 ENSDART00000148958
ALK and LTK ligand 1
chr2_-_25120197 0.11 ENSDART00000132549
propionyl CoA carboxylase, beta polypeptide
chr17_-_23416897 0.11 ENSDART00000163391
si:ch211-149k12.3
chr21_+_40106448 0.11 ENSDART00000100166
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr3_-_39198113 0.11 ENSDART00000102690
zgc:154169
chr23_+_19564392 0.10 ENSDART00000144746
ATPase H+ transporting accessory protein 1 like b
chr21_-_20725853 0.10 ENSDART00000114502
si:ch211-22d5.2
chr10_-_1788376 0.10 ENSDART00000123842
erythrocyte membrane protein band 4.1 like 4A
chr20_+_34320635 0.10 ENSDART00000153207
influenza virus NS1A binding protein a
chr15_+_42599501 0.10 ENSDART00000177646
glutamate receptor, ionotropic, kainate 1b
chr1_+_15204633 0.10 ENSDART00000188410
intelectin 1
chr25_+_30233638 0.10 ENSDART00000192558
ENSDART00000067057
ENSDART00000147327
ENSDART00000145924
ENSDART00000148250
alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase
chr17_-_24364527 0.10 ENSDART00000155192
WD repeat containing planar cell polarity effector
chr17_-_2126517 0.10 ENSDART00000013093
zinc finger, FYVE domain containing 19
chr22_-_38480186 0.10 ENSDART00000171704
heme-binding protein soul4
chr10_+_2232023 0.09 ENSDART00000097695
contactin associated protein like 3
chr11_-_29737088 0.09 ENSDART00000159828
si:ch211-218g23.6
chr2_-_56649883 0.09 ENSDART00000191786
glutathione peroxidase 4b
chr1_-_12393060 0.09 ENSDART00000079782
sodium channel and clathrin linker 1
chr21_+_41649336 0.09 ENSDART00000164694
ENSDART00000181539
protein phosphatase 2, regulatory subunit B, beta b
chr16_+_30438041 0.09 ENSDART00000137977
platelet endothelial aggregation receptor 1
chr3_-_5555500 0.08 ENSDART00000176133
ENSDART00000057464
tripartite motif containing 35-31
chr19_+_30990129 0.08 ENSDART00000052169
ENSDART00000193376
syncoilin, intermediate filament protein
chr7_+_19835569 0.08 ENSDART00000149812
ovo-like zinc finger 1a
chr15_-_25304710 0.08 ENSDART00000190690
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1a
chr23_-_36316352 0.07 ENSDART00000014840
nuclear factor, erythroid 2
chr16_-_8927425 0.07 ENSDART00000000382
trio Rho guanine nucleotide exchange factor b
chr14_-_29859067 0.07 ENSDART00000136380
sorbin and SH3 domain containing 2b
chr14_+_22297257 0.07 ENSDART00000113676
ATPase phospholipid transporting 10B
chr19_-_8604429 0.07 ENSDART00000151165
tripartite motif containing 46b
chr5_+_19261391 0.07 ENSDART00000089173
ATPase phospholipid transporting 8B5a
chr1_-_31140096 0.07 ENSDART00000172243
potassium voltage-gated channel, KQT-like subfamily, member 5b
chr11_+_26363435 0.07 ENSDART00000088800
phosphopantothenoylcysteine synthetase
chr11_-_3574311 0.07 ENSDART00000167064
si:dkey-33m11.7
chr11_+_28476298 0.07 ENSDART00000122319
leucine rich repeat containing 38b
chr21_+_19517492 0.07 ENSDART00000123168
ENSDART00000187993
granzyme K
chr11_-_24458786 0.06 ENSDART00000089713
matrix-remodelling associated 8a
chr22_-_5752009 0.06 ENSDART00000190052
BCDIN3 domain containing
chr4_+_38103421 0.06 ENSDART00000164164
zinc finger protein 1016
chr5_+_19261687 0.06 ENSDART00000139401
ATPase phospholipid transporting 8B5a
chr5_-_30079434 0.05 ENSDART00000133981
beta-carotene oxygenase 2a
chr21_+_27189490 0.05 ENSDART00000125349
BCL2 associated agonist of cell death a
chr8_+_30452945 0.05 ENSDART00000062303
forkhead box D5
chr23_+_44741500 0.05 ENSDART00000166421
ATPase Na+/K+ transporting subunit beta 2a
chr1_+_9708801 0.05 ENSDART00000189621
extracellular leucine-rich repeat and fibronectin type III domain containing 1b
chr17_-_31044803 0.05 ENSDART00000185941
ENSDART00000152016
echinoderm microtubule associated protein like 1
chr4_-_4129187 0.05 ENSDART00000146889
ankyrin repeat and SOCS box containing 15b
chr22_-_13544244 0.05 ENSDART00000110136
contactin associated protein-like 5b
chr15_-_24178893 0.05 ENSDART00000077980
pipecolic acid oxidase
chr11_-_1948784 0.05 ENSDART00000082475
nuclear receptor subfamily 1, group D, member 4b
chr24_+_24809877 0.04 ENSDART00000185117
DnaJ (Hsp40) homolog, subfamily C, member 5 beta
chr14_-_22390821 0.04 ENSDART00000054396
F-box and leucine-rich repeat protein 3, like
chr16_-_30564319 0.04 ENSDART00000145087
lamin A
chr22_+_8612462 0.04 ENSDART00000114586

chr5_-_16983336 0.04 ENSDART00000038740
polypeptide N-acetylgalactosaminyltransferase 9
chr3_+_13637383 0.04 ENSDART00000166000
si:ch211-194b1.1
chr10_+_26935155 0.04 ENSDART00000129993

chr7_+_66048102 0.04 ENSDART00000104523
aryl hydrocarbon receptor nuclear translocator-like 1b
chr14_-_34700633 0.04 ENSDART00000150358
actin binding LIM protein family, member 3
chr6_-_43005901 0.04 ENSDART00000161071
si:ch73-361p23.3
chr11_+_10975012 0.04 ENSDART00000192872
integrin, beta 6
chr8_+_26254903 0.04 ENSDART00000113763
solute carrier family 26, member 6
chr17_-_42213285 0.04 ENSDART00000140549
NK2 homeobox 2a
chr6_+_13742899 0.04 ENSDART00000104722
cyclin-dependent kinase 5, regulatory subunit 2a (p39)
chr25_-_32888115 0.04 ENSDART00000087586
C2 calcium dependent domain containing 4A
chr22_-_600016 0.04 ENSDART00000086434
transmembrane and coiled-coil domain family 2
chr10_-_44341288 0.03 ENSDART00000166131
zinc finger, SWIM-type containing 6
chr3_-_29508959 0.03 ENSDART00000055408
cytohesin 4a
chr1_+_56447107 0.03 ENSDART00000091924

chr8_+_6576940 0.03 ENSDART00000138135
V-set and immunoglobulin domain containing 8b
chr8_+_43016714 0.03 ENSDART00000142671
Ras association (RalGDS/AF-6) domain family member 2a
chr11_+_10975481 0.03 ENSDART00000160488
integrin, beta 6
chr17_-_42213822 0.03 ENSDART00000187904
ENSDART00000180029
NK2 homeobox 2a
chr17_-_6738538 0.03 ENSDART00000157125
visinin-like 1b
chr24_-_31422574 0.03 ENSDART00000158567
cyclic nucleotide gated channel beta 3, tandem duplicate 1
chr8_+_25351863 0.03 ENSDART00000034092
deoxyribonuclease I-like 1-like
chr19_+_43314700 0.03 ENSDART00000049045
ENSDART00000133158
matrilin 1
chr9_+_21993092 0.03 ENSDART00000059693
crystallin, gamma M7
chr16_-_24561354 0.02 ENSDART00000193278
ENSDART00000126274
si:ch211-79k12.2
chr6_-_39605734 0.02 ENSDART00000044276
ENSDART00000179059
disco-interacting protein 2 homolog Bb
chr15_-_34322915 0.02 ENSDART00000190543
ENSDART00000019651
ENSDART00000193601
diacylglycerol kinase, beta
chr5_+_19413838 0.02 ENSDART00000089014
ENSDART00000146215
myosin IHa
chr11_+_22134540 0.02 ENSDART00000190502
si:dkey-91m3.1
chr1_-_29658721 0.02 ENSDART00000132063
si:dkey-1h24.6
chr7_+_48675347 0.02 ENSDART00000157917
ENSDART00000185580
transient receptor potential cation channel, subfamily M, member 5
chr25_-_19374710 0.02 ENSDART00000184483
ENSDART00000188706
microtubule-associated protein 1Ab
chr11_-_42396302 0.02 ENSDART00000165624
sarcolemma associated protein a
chr9_-_48937089 0.02 ENSDART00000193442
ceramide synthase 6
chr3_+_1016404 0.02 ENSDART00000189545
si:ch1073-464p5.5
chr11_+_30672282 0.02 ENSDART00000023981
ENSDART00000188846
tau tubulin kinase 1a
chr16_+_12632428 0.02 ENSDART00000184600
ENSDART00000180537
N-acetyltransferase 14 (GCN5-related, putative)
chr3_+_60761811 0.02 ENSDART00000053482
TSEN54 tRNA splicing endonuclease subunit
chr9_+_13682133 0.02 ENSDART00000175639
membrane protein, palmitoylated 4a (MAGUK p55 subfamily member 4)
chr5_+_52167986 0.02 ENSDART00000162256
ENSDART00000073626
solute carrier family 14 (urea transporter), member 2
chr17_-_27976031 0.02 ENSDART00000154829
platelet-activating factor receptor
chr19_+_41173386 0.02 ENSDART00000142773
ankyrin repeat and SOCS box containing 4
chr6_+_2030703 0.01 ENSDART00000109679
ENSDART00000187502
ENSDART00000191165
ENSDART00000187544
quattro
chr25_+_11389220 0.01 ENSDART00000187787
si:ch73-141f14.1
chr12_+_7399403 0.01 ENSDART00000103526
BicC family RNA binding protein 1b
chr9_+_29548195 0.01 ENSDART00000176057
ring finger protein 17
chr21_+_21812311 0.01 ENSDART00000151253
sialidase 3 (membrane sialidase), tandem duplicate 4
chr8_-_29706882 0.01 ENSDART00000045909
perforin 1.5
chr20_-_9980318 0.01 ENSDART00000080664
zgc:86709
chr19_-_8096984 0.01 ENSDART00000146987
si:dkey-266f7.9
chr17_-_36513936 0.00 ENSDART00000165075
si:dkey-25g12.4
chr8_+_25352268 0.00 ENSDART00000187829
deoxyribonuclease I-like 1-like
chr11_+_19159083 0.00 ENSDART00000138964
ADAM metallopeptidase with thrombospondin type 1 motif, 9
chr2_+_49417900 0.00 ENSDART00000122742
ENSDART00000160783
RAR-related orphan receptor C b
chr13_+_29470442 0.00 ENSDART00000028417
leucine-rich repeat, immunoglobulin-like and transmembrane domains 2
chr3_-_34115886 0.00 ENSDART00000151531
immunoglobulin heavy variable 4-1
chr14_-_42997145 0.00 ENSDART00000172801
protocadherin 10b

Network of associatons between targets according to the STRING database.

First level regulatory network of rorc

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0061037 negative regulation of chondrocyte differentiation(GO:0032331) negative regulation of cartilage development(GO:0061037) negative regulation of chondrocyte development(GO:0061182) regulation of bone mineralization involved in bone maturation(GO:1900157) negative regulation of bone mineralization involved in bone maturation(GO:1900158) negative regulation of bone development(GO:1903011)
0.2 1.2 GO:0008591 regulation of Wnt signaling pathway, calcium modulating pathway(GO:0008591) negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.1 0.3 GO:0009098 leucine biosynthetic process(GO:0009098)
0.0 0.2 GO:0070376 ERK5 cascade(GO:0070375) regulation of ERK5 cascade(GO:0070376) positive regulation of ERK5 cascade(GO:0070378)
0.0 0.2 GO:2000171 negative regulation of dendrite development(GO:2000171)
0.0 0.1 GO:0070589 cell wall biogenesis(GO:0042546) cell wall macromolecule biosynthetic process(GO:0044038) cellular component macromolecule biosynthetic process(GO:0070589)
0.0 0.1 GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling(GO:0010882)
0.0 0.1 GO:0009838 abscission(GO:0009838) mitotic cytokinesis checkpoint(GO:0044878)
0.0 0.2 GO:0006572 tyrosine catabolic process(GO:0006572)
0.0 0.5 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.0 0.1 GO:0021530 spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.0 0.2 GO:0042214 carotene metabolic process(GO:0016119) carotene catabolic process(GO:0016121) terpene metabolic process(GO:0042214) terpene catabolic process(GO:0046247)
0.0 0.1 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.2 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.1 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.0 0.1 GO:0035552 oxidative single-stranded DNA demethylation(GO:0035552)
0.0 0.1 GO:1903798 regulation of production of small RNA involved in gene silencing by RNA(GO:0070920) regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903798)
0.0 0.2 GO:0030011 maintenance of cell polarity(GO:0030011)
0.0 0.4 GO:0043631 mRNA polyadenylation(GO:0006378) RNA polyadenylation(GO:0043631)
0.0 0.3 GO:0032438 melanosome organization(GO:0032438)
0.0 0.2 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.0 0.0 GO:0046440 lysine catabolic process(GO:0006554) L-lysine catabolic process to acetyl-CoA(GO:0019474) L-lysine catabolic process(GO:0019477) L-lysine metabolic process(GO:0046440)
0.0 0.1 GO:0070285 pigment cell development(GO:0070285)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0097541 axonemal basal plate(GO:0097541)
0.0 0.1 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
0.0 0.1 GO:0008247 1-alkyl-2-acetylglycerophosphocholine esterase complex(GO:0008247)
0.0 0.1 GO:0033181 plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
0.0 0.8 GO:0032432 actin filament bundle(GO:0032432)
0.0 0.2 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.2 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0031005 filamin binding(GO:0031005)
0.1 0.3 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.1 0.4 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.1 0.4 GO:0070004 cysteine-type exopeptidase activity(GO:0070004)
0.1 0.3 GO:0052656 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.1 0.2 GO:0003868 4-hydroxyphenylpyruvate dioxygenase activity(GO:0003868)
0.1 0.2 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 0.2 GO:0030298 receptor signaling protein tyrosine kinase activator activity(GO:0030298)
0.0 0.2 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.0 0.2 GO:0005483 soluble NSF attachment protein activity(GO:0005483)
0.0 0.2 GO:0010436 beta-carotene 15,15'-monooxygenase activity(GO:0003834) carotenoid dioxygenase activity(GO:0010436)
0.0 0.2 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.1 GO:0042834 peptidoglycan binding(GO:0042834)
0.0 0.3 GO:0004181 metallocarboxypeptidase activity(GO:0004181)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 0.3 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism