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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for rreb1a+rreb1b
Z-value: 1.60
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Transcription factors associated with rreb1a+rreb1b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| rreb1b | dr11_v1_chr2_+_21048661_21048661 | -0.87 | 3.2e-06 | Click! |
| rreb1a | dr11_v1_chr24_-_2381143_2381143 | -0.85 | 1.0e-05 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr16_-_54640315 Show fit | 20.39 |
ENSDART00000101207
|
sperm associated antigen 1b |
|
| chr25_+_258883 Show fit | 14.91 |
ENSDART00000155256
|
zgc:92481 |
|
| chr2_-_44183613 Show fit | 5.89 |
ENSDART00000079596
|
cell adhesion molecule 3 |
|
| chr16_-_54405976 Show fit | 5.32 |
ENSDART00000055395
|
odd-skipped related transciption factor 2 |
|
| chr2_-_44183451 Show fit | 5.03 |
ENSDART00000111246
|
cell adhesion molecule 3 |
|
| chr8_+_54284961 Show fit | 4.93 |
ENSDART00000122692
|
plexin D1 |
|
| chr19_+_56351 Show fit | 4.57 |
ENSDART00000168334
|
collagen, type XIV, alpha 1b |
|
| chr17_-_12408109 Show fit | 4.32 |
ENSDART00000155509
|
ankyrin repeat and EF-hand domain containing 1b |
|
| chr22_-_34872533 Show fit | 4.29 |
ENSDART00000167176
|
slit homolog 1b (Drosophila) |
|
| chr5_-_3839285 Show fit | 4.19 |
ENSDART00000122292
|
MLX interacting protein like |
Network of associatons between targets according to the STRING database.
First level regulatory network of rreb1a+rreb1b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 22.1 | GO:0070286 | axonemal dynein complex assembly(GO:0070286) |
| 0.0 | 13.4 | GO:0046777 | protein autophosphorylation(GO:0046777) |
| 0.2 | 4.9 | GO:1902287 | semaphorin-plexin signaling pathway involved in neuron projection guidance(GO:1902285) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287) |
| 0.0 | 3.9 | GO:0048793 | pronephros development(GO:0048793) |
| 0.6 | 3.8 | GO:0044341 | sodium-dependent phosphate transport(GO:0044341) |
| 0.4 | 3.8 | GO:0007223 | Wnt signaling pathway, calcium modulating pathway(GO:0007223) |
| 0.1 | 3.6 | GO:0021602 | cranial nerve morphogenesis(GO:0021602) |
| 0.8 | 3.2 | GO:0009202 | purine deoxyribonucleoside diphosphate metabolic process(GO:0009182) deoxyribonucleoside triphosphate biosynthetic process(GO:0009202) dGDP metabolic process(GO:0046066) |
| 0.2 | 3.1 | GO:0001539 | cilium or flagellum-dependent cell motility(GO:0001539) cilium-dependent cell motility(GO:0060285) |
| 0.1 | 3.0 | GO:0018149 | peptide cross-linking(GO:0018149) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 13.8 | GO:0005829 | cytosol(GO:0005829) |
| 0.2 | 4.9 | GO:0002116 | semaphorin receptor complex(GO:0002116) |
| 0.2 | 3.8 | GO:0005903 | brush border(GO:0005903) |
| 0.0 | 3.3 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.7 | 2.8 | GO:0097519 | DNA recombinase complex(GO:0097519) |
| 0.5 | 2.8 | GO:0000801 | central element(GO:0000801) |
| 0.1 | 2.8 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.2 | 2.4 | GO:1990246 | uniplex complex(GO:1990246) |
| 0.0 | 2.2 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.1 | 2.1 | GO:0031430 | M band(GO:0031430) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.9 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.1 | 4.8 | GO:0017147 | Wnt-protein binding(GO:0017147) |
| 0.6 | 3.8 | GO:0005436 | sodium:phosphate symporter activity(GO:0005436) |
| 0.0 | 3.6 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.2 | 3.2 | GO:0004017 | adenylate kinase activity(GO:0004017) |
| 0.2 | 3.0 | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity(GO:0003810) |
| 0.4 | 2.9 | GO:0001948 | glycoprotein binding(GO:0001948) proteoglycan binding(GO:0043394) |
| 0.9 | 2.8 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.7 | 2.7 | GO:0008746 | NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652) |
| 0.1 | 2.2 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.8 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.1 | 4.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 3.6 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.1 | 3.1 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.0 | 2.6 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 2.2 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.2 | 1.9 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 1.7 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.1 | 1.6 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.1 | 1.6 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.9 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.0 | 4.2 | REACTOME INTEGRATION OF ENERGY METABOLISM | Genes involved in Integration of energy metabolism |
| 0.1 | 2.8 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.0 | 1.8 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 1.7 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.0 | 1.7 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.0 | 1.7 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 1.7 | REACTOME METABOLISM OF CARBOHYDRATES | Genes involved in Metabolism of carbohydrates |
| 0.1 | 1.5 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.0 | 1.5 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |