ISMARA results: si:dkey-149i17.7

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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for si:dkey-149i17.7_zic1

Z-value: 0.82

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Transcription factors associated with si:dkey-149i17.7_zic1

Gene Symbol	Gene ID	Gene Info
si_dkey-149i17.7 NCBI UniProt	ENSDARG00000094684	si_dkey-149i17.7
zic1 NCBI UniProt	ENSDARG00000015567	zic family member 1 (odd-paired homolog, Drosophila)

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
si:dkey-149i17.7	dr11_v1_chr2_+_24885987_24885987	-0.19	4.5e-01	Click!
zic1	dr11_v1_chr24_-_4973765_4973765	0.06	8.2e-01	Click!

Activity profile of si:dkey-149i17.7_zic1 motif

Sorted Z-values of si:dkey-149i17.7_zic1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr13_-_6250317 Show fit	3.26	ENSDART00000180416	tuba4l NCBI UniProt Show fit	tubulin, alpha 4 like
chr8_+_14987006 Show fit	3.13	ENSDART00000045038	fnbp1l NCBI UniProt Show fit	formin binding protein 1-like
chr2_+_41526904 Show fit	2.88	ENSDART00000127520	acvr1l NCBI UniProt Show fit	activin A receptor, type 1 like
chr20_+_20731633 Show fit	2.26	ENSDART00000191952 ENSDART00000165224	ppp1r13bb NCBI UniProt Show fit	protein phosphatase 1, regulatory subunit 13Bb
chr6_+_10338554 Show fit	2.19	ENSDART00000186936	cobll1a NCBI UniProt Show fit	cordon-bleu WH2 repeat protein-like 1a
chr15_+_20239141 Show fit	2.12	ENSDART00000101152 ENSDART00000152473	spint2 NCBI UniProt Show fit	serine peptidase inhibitor, Kunitz type, 2
chr22_-_20924564 Show fit	2.05	ENSDART00000100642 ENSDART00000032770	ell NCBI UniProt Show fit	elongation factor RNA polymerase II
chr15_+_45591669 Show fit	2.03	ENSDART00000157459	atg16l1 NCBI UniProt Show fit	ATG16 autophagy related 16-like 1 (S. cerevisiae)
chr16_+_31511739 Show fit	1.94	ENSDART00000049420	ndrg1b NCBI UniProt Show fit	N-myc downstream regulated 1b
chr24_-_34680956 Show fit	1.92	ENSDART00000171009	ctnna1 NCBI UniProt Show fit	catenin (cadherin-associated protein), alpha 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of si:dkey-149i17.7_zic1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	3.3	GO:0003232	bulbus arteriosus development(GO:0003232)
0.0	3.1	GO:0006914	autophagy(GO:0006914)
0.7	2.9	GO:0035124	embryonic caudal fin morphogenesis(GO:0035124)
0.5	2.5	GO:0006011	UDP-glucose metabolic process(GO:0006011)
0.2	2.3	GO:0070328	acylglycerol homeostasis(GO:0055090) triglyceride homeostasis(GO:0070328)
0.4	2.2	GO:0010719	photoreceptor cell morphogenesis(GO:0008594) negative regulation of epithelial to mesenchymal transition(GO:0010719)
0.3	2.1	GO:0042795	snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.4	2.0	GO:0039694	viral genome replication(GO:0019079) negative stranded viral RNA replication(GO:0039689) viral RNA genome replication(GO:0039694) RNA replication(GO:0039703) multi-organism biosynthetic process(GO:0044034)
0.3	1.9	GO:0032287	peripheral nervous system myelin maintenance(GO:0032287)
0.1	1.9	GO:0030311	poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)

Showing 1 to 10 of 91 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.3	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.0	3.3	GO:0005938	cell cortex(GO:0005938)
0.6	2.9	GO:0070724	BMP receptor complex(GO:0070724)
0.3	2.2	GO:0000346	transcription export complex(GO:0000346)
0.0	2.2	GO:0030864	cortical actin cytoskeleton(GO:0030864)
0.0	2.1	GO:0008023	transcription elongation factor complex(GO:0008023)
0.1	2.0	GO:0000421	autophagosome membrane(GO:0000421)
0.1	1.9	GO:0030057	desmosome(GO:0030057)
0.1	1.7	GO:0002102	podosome(GO:0002102)
0.1	1.7	GO:0005666	DNA-directed RNA polymerase III complex(GO:0005666)

Showing 1 to 10 of 41 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.9	GO:0042802	identical protein binding(GO:0042802)
0.1	3.3	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.2	2.9	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.2	2.8	GO:0002039	p53 binding(GO:0002039)
0.5	2.5	GO:0003983	UTP:glucose-1-phosphate uridylyltransferase activity(GO:0003983) UTP-monosaccharide-1-phosphate uridylyltransferase activity(GO:0051748)
0.5	2.3	GO:0070644	vitamin D response element binding(GO:0070644)
0.1	2.2	GO:0045159	myosin II binding(GO:0045159)
0.1	2.2	GO:0003785	actin monomer binding(GO:0003785)
0.0	2.0	GO:0008013	beta-catenin binding(GO:0008013)
0.1	1.9	GO:0008532	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)

Showing 1 to 10 of 76 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	3.3	PID S1P S1P2 PATHWAY	S1P2 pathway
0.1	2.8	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.1	2.3	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.1	1.9	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.1	1.6	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.0	1.3	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.1	1.2	PID ERBB2 ERBB3 PATHWAY	ErbB2/ErbB3 signaling events
0.0	1.0	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.0	1.0	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.0	0.9	PID EPHA FWDPATHWAY	EPHA forward signaling

Showing 1 to 10 of 24 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	3.3	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.1	3.0	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.1	2.9	REACTOME G1 PHASE	Genes involved in G1 Phase
0.1	2.3	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.1	2.1	REACTOME ELONGATION ARREST AND RECOVERY	Genes involved in Elongation arrest and recovery
0.1	1.9	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.1	1.7	REACTOME RNA POL III CHAIN ELONGATION	Genes involved in RNA Polymerase III Chain Elongation
0.1	1.6	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.1	1.6	REACTOME EGFR DOWNREGULATION	Genes involved in EGFR downregulation
0.0	1.6	REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN	Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein

Showing 1 to 10 of 37 entries

Results for si:dkey-149i17.7_zic1

Z-value: 0.82

Motif logo

Transcription factors associated with si:dkey-149i17.7_zic1

Activity-expression correlation:

Activity profile of si:dkey-149i17.7_zic1 motif

Sorted Z-values of si:dkey-149i17.7_zic1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of si:dkey-149i17.7_zic1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: