ISMARA results: si:dkey-18a10.3

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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for si:dkey-18a10.3

Z-value: 0.53

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Transcription factors associated with si:dkey-18a10.3

Gene Symbol	Gene ID	Gene Info
si_dkey-18a10.3 NCBI UniProt	ENSDARG00000090814	si_dkey-18a10.3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
si:dkey-18a10.3	dr11_v1_chr10_-_33572441_33572441	0.73	5.7e-04	Click!

Activity profile of si:dkey-18a10.3 motif

Sorted Z-values of si:dkey-18a10.3 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr23_-_31372639 Show fit	1.65	ENSDART00000179908 ENSDART00000135620 ENSDART00000053367	hmgn3 NCBI UniProt Show fit	high mobility group nucleosomal binding domain 3
chr6_+_518979 Show fit	1.50	ENSDART00000151012	CACNA1I (1 of many) NCBI UniProt Show fit	si:ch73-379f7.5
chr16_+_30575901 Show fit	1.42	ENSDART00000077231	mc2r NCBI UniProt Show fit	melanocortin 2 receptor
chr9_+_44431174 Show fit	1.29	ENSDART00000149726	ppp1r1c NCBI UniProt Show fit	protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr16_+_34523515 Show fit	1.16	ENSDART00000041007	stmn1b NCBI UniProt Show fit	stathmin 1b
chr10_-_36682509 Show fit	1.16	ENSDART00000148093 ENSDART00000063365	dnajb13 NCBI UniProt Show fit	DnaJ (Hsp40) homolog, subfamily B, member 13
chr15_+_36941490 Show fit	1.10	ENSDART00000172664	kirrel3l NCBI UniProt Show fit	kirre like nephrin family adhesion molecule 3, like
chr3_-_41535647 Show fit	1.09	ENSDART00000153723 ENSDART00000154198	si:ch211-222n22.1 NCBI UniProt Show fit	si:ch211-222n22.1
chr6_+_49095646 Show fit	1.04	ENSDART00000103385	slc25a55a NCBI UniProt Show fit	solute carrier family 25, member 55a
chr25_-_18470695 Show fit	1.01	ENSDART00000034377	cpa5 NCBI UniProt Show fit	carboxypeptidase A5

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of si:dkey-18a10.3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	1.7	GO:0061178	insulin secretion involved in cellular response to glucose stimulus(GO:0035773) regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
0.1	1.4	GO:0033555	multicellular organismal response to stress(GO:0033555)
0.0	1.2	GO:0007019	microtubule depolymerization(GO:0007019)
0.0	1.1	GO:0007520	myoblast fusion(GO:0007520)
0.3	1.0	GO:0090219	negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) negative regulation of lipid kinase activity(GO:0090219)
0.1	1.0	GO:0043490	acidic amino acid transport(GO:0015800) aspartate transport(GO:0015810) L-glutamate transport(GO:0015813) malate-aspartate shuttle(GO:0043490)
0.1	1.0	GO:1902108	regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902108)
0.0	0.9	GO:0051639	actin filament network formation(GO:0051639)
0.0	0.8	GO:0000413	protein peptidyl-prolyl isomerization(GO:0000413)
0.0	0.8	GO:0071391	cellular response to estrogen stimulus(GO:0071391)

Showing 1 to 10 of 49 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.0	GO:0031514	motile cilium(GO:0031514)
0.1	0.9	GO:0031597	cytosolic proteasome complex(GO:0031597)
0.0	0.9	GO:0032587	ruffle membrane(GO:0032587)
0.0	0.8	GO:0043209	myelin sheath(GO:0043209)
0.1	0.6	GO:0098642	collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.1	0.6	GO:0005832	chaperonin-containing T-complex(GO:0005832)
0.0	0.6	GO:0044666	MLL3/4 complex(GO:0044666)
0.0	0.6	GO:0016342	catenin complex(GO:0016342)
0.0	0.5	GO:0031080	nuclear pore outer ring(GO:0031080)
0.1	0.3	GO:1990604	IRE1-TRAF2-ASK1 complex(GO:1990604)

Showing 1 to 10 of 15 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.8	GO:0004864	protein phosphatase inhibitor activity(GO:0004864)
0.1	1.7	GO:0031492	nucleosomal DNA binding(GO:0031492)
0.2	1.4	GO:0004977	melanocortin receptor activity(GO:0004977)
0.0	1.1	GO:0051082	unfolded protein binding(GO:0051082)
0.1	1.0	GO:0015183	L-aspartate transmembrane transporter activity(GO:0015183)
0.0	1.0	GO:0004181	metallocarboxypeptidase activity(GO:0004181)
0.0	0.9	GO:0031593	polyubiquitin binding(GO:0031593)
0.0	0.8	GO:0008013	beta-catenin binding(GO:0008013)
0.1	0.6	GO:0070698	type I activin receptor binding(GO:0070698)
0.1	0.6	GO:0031826	type 2A serotonin receptor binding(GO:0031826)

Showing 1 to 10 of 38 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.3	NABA COLLAGENS	Genes encoding collagen proteins
0.1	0.8	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	0.6	PID ARF6 PATHWAY	Arf6 signaling events
0.1	0.5	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.0	0.4	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0	0.3	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0	0.1	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network

Showing 1 to 7 of 7 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.4	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.0	1.3	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.1	0.8	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.1	0.7	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0	0.6	REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0	0.4	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.0	0.4	REACTOME GLUCOSE TRANSPORT	Genes involved in Glucose transport
0.0	0.3	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.0	0.3	REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0	0.3	REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	Genes involved in AKT phosphorylates targets in the cytosol

Showing 1 to 10 of 15 entries

Results for si:dkey-18a10.3

Z-value: 0.53

Motif logo

Transcription factors associated with si:dkey-18a10.3

Activity-expression correlation:

Activity profile of si:dkey-18a10.3 motif

Sorted Z-values of si:dkey-18a10.3 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of si:dkey-18a10.3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: