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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for six6a+six6b

Z-value: 0.67

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Transcription factors associated with six6a+six6b

Gene Symbol Gene ID Gene Info
six6a
ENSDARG00000025187 SIX homeobox 6a
six6b
ENSDARG00000031316 SIX homeobox 6b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
six6bdr11_v1_chr20_-_20533865_20533865-0.781.2e-04Click!
six6adr11_v1_chr13_+_31583034_315830340.493.7e-02Click!

Activity profile of six6a+six6b motif

Sorted Z-values of six6a+six6b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr9_+_38883388 1.70 ENSDART00000135902
map2
microtubule-associated protein 2
chr6_-_23002373 1.68 ENSDART00000037709
ENSDART00000170369
nol11
nucleolar protein 11
chr24_-_26632171 1.56 ENSDART00000008374
ENSDART00000017384
tnikb
TRAF2 and NCK interacting kinase b
chr2_-_6065416 1.37 ENSDART00000037698
uck2b
uridine-cytidine kinase 2b
chr15_+_46313082 1.26 ENSDART00000153830
si:ch1073-190k2.1
si:ch1073-190k2.1
chr8_+_17143501 1.24 ENSDART00000061758
mier3b
mesoderm induction early response 1, family member 3 b
chr5_-_43859148 1.23 ENSDART00000162746
ENSDART00000128763
si:ch211-204c21.1
si:ch211-204c21.1
chr4_+_23117557 1.21 ENSDART00000066909
slc35e3
solute carrier family 35, member E3
chr13_+_46944607 1.20 ENSDART00000187352
fbxo5
F-box protein 5
chr2_-_23391266 1.16 ENSDART00000159048
ivns1abpb
influenza virus NS1A binding protein b
chr10_+_39199547 1.15 ENSDART00000075943
ei24
etoposide induced 2.4
chr10_+_23060391 1.15 ENSDART00000079711
slc25a1a
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1a
chr7_+_71955486 1.14 ENSDART00000189349
CABZ01071171.1
Danio rerio low density lipoprotein receptor-related protein 4 (lrp4), mRNA.
chr8_-_12847483 1.14 ENSDART00000146186
si:dkey-104n9.1
si:dkey-104n9.1
chr7_+_22313533 1.14 ENSDART00000123457
TMEM102
si:dkey-11f12.2
chr11_+_1867613 1.11 ENSDART00000065470
rbms2a
RNA binding motif, single stranded interacting protein 2a
chr13_+_49727333 1.05 ENSDART00000168799
ENSDART00000037559
ggps1
geranylgeranyl diphosphate synthase 1
chr24_-_19719240 1.04 ENSDART00000135405
csrnp1b
cysteine-serine-rich nuclear protein 1b
chr8_+_23826985 1.02 ENSDART00000187430
mapk14a
mitogen-activated protein kinase 14a
chr1_+_31657842 1.02 ENSDART00000057880
poll
polymerase (DNA directed), lambda
chr2_+_1881334 1.01 ENSDART00000161420
adgrl2b.1
adhesion G protein-coupled receptor L2b, tandem duplicate 1
chr17_+_28706946 0.99 ENSDART00000126967
strn3
striatin, calmodulin binding protein 3
chr1_+_31658011 0.97 ENSDART00000192203
poll
polymerase (DNA directed), lambda
chr5_+_36661058 0.96 ENSDART00000125653
capns1a
calpain, small subunit 1 a
chr16_+_30002605 0.96 ENSDART00000160555
sema6e
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6E
chr11_+_45286911 0.94 ENSDART00000181763
pycr1b
pyrroline-5-carboxylate reductase 1b
chr9_-_11676491 0.91 ENSDART00000022358
zc3h15
zinc finger CCCH-type containing 15
chr25_+_1335530 0.90 ENSDART00000090803
fem1b
fem-1 homolog b (C. elegans)
chr2_+_30249977 0.90 ENSDART00000109160
ENSDART00000135171
tmem70
transmembrane protein 70
chr19_+_41479990 0.89 ENSDART00000087187
ago2
argonaute RISC catalytic component 2
chr19_+_206835 0.85 ENSDART00000161137
scn1bb
sodium channel, voltage-gated, type I, beta b
chr23_-_36439961 0.85 ENSDART00000187907
csad
cysteine sulfinic acid decarboxylase
chr12_-_27212596 0.84 ENSDART00000153101
psme3
proteasome activator subunit 3
chr7_+_38808027 0.82 ENSDART00000052323
harbi1
harbinger transposase derived 1
chr3_+_13850163 0.81 ENSDART00000164872
ilf3b
interleukin enhancer binding factor 3b
chr15_-_25094026 0.81 ENSDART00000129154
exo5
exonuclease 5
chr23_+_1702624 0.80 ENSDART00000149357
rabggta
Rab geranylgeranyltransferase, alpha subunit
chr9_-_53062083 0.80 ENSDART00000122155
zmp:0000000936
zmp:0000000936
chr5_+_25304499 0.80 ENSDART00000163425
carnmt1
carnosine N-methyltransferase 1
chr5_-_39736383 0.79 ENSDART00000127123
rasgef1ba
RasGEF domain family, member 1Ba
chr25_+_33072676 0.78 ENSDART00000182885
ENSDART00000181516
tln2b
talin 2b
chr19_-_46018152 0.77 ENSDART00000159206
krit1
KRIT1, ankyrin repeat containing
chr1_+_17527342 0.77 ENSDART00000139702
ENSDART00000140076
ENSDART00000005593
casp3a
caspase 3, apoptosis-related cysteine peptidase a
chr15_-_34934784 0.76 ENSDART00000190848
dhx16
DEAH (Asp-Glu-Ala-His) box polypeptide 16
chr17_+_25331576 0.76 ENSDART00000157309
tmem54a
transmembrane protein 54a
chr12_+_47448558 0.76 ENSDART00000185689
ENSDART00000105328
fmn2b
formin 2b
chr14_+_22467672 0.75 ENSDART00000079409
ENSDART00000136597
nudt22
nudix (nucleoside diphosphate linked moiety X)-type motif 22
chr4_-_75172216 0.74 ENSDART00000127522
naa40
N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae)
chr23_-_36934944 0.71 ENSDART00000109976
ENSDART00000162179
acap3a
ArfGAP with coiled-coil, ankyrin repeat and PH domains 3a
chr10_-_38243851 0.68 ENSDART00000166108
usp25
ubiquitin specific peptidase 25
chr8_-_2602572 0.68 ENSDART00000110482
zdhhc12a
zinc finger, DHHC-type containing 12a
chr18_+_16133595 0.64 ENSDART00000080423
ctsd
cathepsin D
chr1_+_45925365 0.64 ENSDART00000144245
eif5b
eukaryotic translation initiation factor 5B
chr2_+_37245382 0.63 ENSDART00000004626
sec62
SEC62 homolog, preprotein translocation factor
chr14_+_26759332 0.62 ENSDART00000088484
ahnak
AHNAK nucleoprotein
chr8_-_38810233 0.61 ENSDART00000085304
pcsk5b
proprotein convertase subtilisin/kexin type 5b
chr15_-_34878388 0.59 ENSDART00000154094
mgat1a
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase a
chr13_-_24260609 0.59 ENSDART00000138747
urb2
URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
chr2_-_9607879 0.58 ENSDART00000056899
txndc12
thioredoxin domain containing 12 (endoplasmic reticulum)
chr15_-_25527580 0.57 ENSDART00000167005
ENSDART00000157498
hif1al
hypoxia-inducible factor 1, alpha subunit, like
chr3_-_12227359 0.57 ENSDART00000167356
tfap4
transcription factor AP-4 (activating enhancer binding protein 4)
chr2_+_51796441 0.56 ENSDART00000165151
crygn1
crystallin, gamma N1
chr15_-_37867995 0.55 ENSDART00000192698
si:dkey-238d18.4
si:dkey-238d18.4
chr3_-_21106093 0.54 ENSDART00000156566
maza
MYC-associated zinc finger protein a (purine-binding transcription factor)
chr10_+_44903676 0.52 ENSDART00000158553
zgc:114173
zgc:114173
chr18_+_38192499 0.51 ENSDART00000191849
nucb2b
nucleobindin 2b
chr21_+_6197223 0.50 ENSDART00000147716
si:dkey-93m18.3
si:dkey-93m18.3
chr19_-_20777351 0.49 ENSDART00000019206
ngly1
N-glycanase 1
chr5_-_66749535 0.46 ENSDART00000132183
kat5b
K(lysine) acetyltransferase 5b
chr5_-_41638039 0.46 ENSDART00000144525
epg5
ectopic P-granules autophagy protein 5 homolog (C. elegans)
chr2_+_23039041 0.46 ENSDART00000056921
csnk1g2a
casein kinase 1, gamma 2a
chr23_+_16831063 0.45 ENSDART00000104782
zgc:173570
zgc:173570
chr16_-_36979592 0.45 ENSDART00000168443
snrnp48
small nuclear ribonucleoprotein 48 (U11/U12)
chr20_-_51656512 0.45 ENSDART00000129965
LO018154.1

chr7_+_24006875 0.43 ENSDART00000033755
homezb
homeobox and leucine zipper encoding b
chr1_-_55888970 0.42 ENSDART00000064194
asf1bb
anti-silencing function 1Bb histone chaperone
chr6_-_9646275 0.42 ENSDART00000012903
wdr12
WD repeat domain 12
chr24_-_7587401 0.41 ENSDART00000093163
galnt11
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)
chr14_+_50770537 0.40 ENSDART00000158723
sncb
synuclein, beta
chr3_-_39305291 0.38 ENSDART00000102674
plcd3a
phospholipase C, delta 3a
chr10_+_45302425 0.38 ENSDART00000159954
zmiz2
zinc finger, MIZ-type containing 2
chr20_+_42918755 0.35 ENSDART00000134855
efr3bb
EFR3 homolog Bb (S. cerevisiae)
chr7_+_29177191 0.34 ENSDART00000008096
aph1b
APH1B gamma secretase subunit
chr18_-_41164277 0.34 ENSDART00000187766
ENSDART00000185375
CABZ01005876.1

chr18_+_43183749 0.34 ENSDART00000151166
nectin1b
nectin cell adhesion molecule 1b
chr23_+_7710447 0.33 ENSDART00000168199
kif3b
kinesin family member 3B
chr8_+_10001805 0.33 ENSDART00000132894
si:dkey-8e10.2
si:dkey-8e10.2
chr20_-_36393555 0.33 ENSDART00000153421
si:dkey-1j5.4
si:dkey-1j5.4
chr22_-_21845685 0.33 ENSDART00000105564
aes
amino-terminal enhancer of split
chr6_-_16456093 0.31 ENSDART00000083305
ENSDART00000181640
slc19a2
solute carrier family 19 (thiamine transporter), member 2
chr8_-_8346023 0.31 ENSDART00000164731
ENSDART00000188259
tsr2
TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)
chr7_+_69428831 0.31 ENSDART00000186975
elp5
elongator acetyltransferase complex subunit 5
chr20_+_26987416 0.31 ENSDART00000012816
sel1l
sel-1 suppressor of lin-12-like (C. elegans)
chr23_+_30898013 0.31 ENSDART00000146859
cables2a
Cdk5 and Abl enzyme substrate 2a
chr19_-_32710922 0.30 ENSDART00000004034
hpca
hippocalcin
chr11_+_5681762 0.30 ENSDART00000179139
arid3a
AT rich interactive domain 3A (BRIGHT-like)
chr6_-_50685862 0.29 ENSDART00000134146
mtss1
metastasis suppressor 1
chr11_-_27702778 0.29 ENSDART00000045942
ENSDART00000125352
phf2
PHD finger protein 2
chr18_+_12058403 0.28 ENSDART00000140854
ENSDART00000193632
ENSDART00000190519
ENSDART00000190685
ENSDART00000112671
bicd1a
bicaudal D homolog 1a
chr10_-_24648228 0.28 ENSDART00000081834
ENSDART00000132830
stoml3b
stomatin (EPB72)-like 3b
chr11_-_17755444 0.28 ENSDART00000154627
eogt
EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
chr13_+_22555342 0.27 ENSDART00000193633
bmpr1aa
bone morphogenetic protein receptor, type IAa
chr2_+_13907452 0.27 ENSDART00000169724
ENSDART00000190691
zgc:66475
zgc:66475
chr5_-_57526807 0.27 ENSDART00000022866
pisd
phosphatidylserine decarboxylase
chr25_-_10630496 0.27 ENSDART00000153639
ENSDART00000181722
ENSDART00000177834
ppp6r3
protein phosphatase 6, regulatory subunit 3
chr3_+_18840810 0.27 ENSDART00000181137
ENSDART00000128626
ENSDART00000133332
tmem104
transmembrane protein 104
chr15_-_31419805 0.27 ENSDART00000060111
or111-11
odorant receptor, family D, subfamily 111, member 11
chr15_-_6946286 0.27 ENSDART00000019330
ech1
enoyl CoA hydratase 1, peroxisomal
chr22_-_12862415 0.26 ENSDART00000145156
ENSDART00000137280
glsa
glutaminase a
chr15_+_34934568 0.26 ENSDART00000165210
zgc:66024
zgc:66024
chr1_-_19233890 0.25 ENSDART00000127145
ptprdb
protein tyrosine phosphatase, receptor type, D, b
chr19_-_18152942 0.24 ENSDART00000190182
nfe2l3
nuclear factor, erythroid 2-like 3
chr18_+_36786842 0.24 ENSDART00000123264
si:ch211-160d20.3
si:ch211-160d20.3
chr8_-_28357177 0.23 ENSDART00000182319
KLHL12 (1 of many)
kelch like family member 12
chr20_-_51946052 0.23 ENSDART00000074325
dusp10
dual specificity phosphatase 10
chr25_+_15287036 0.23 ENSDART00000147572
hipk3a
homeodomain interacting protein kinase 3a
chr24_+_13017586 0.23 ENSDART00000142457
stau2
staufen double-stranded RNA binding protein 2
chr22_+_19640309 0.22 ENSDART00000061725
ENSDART00000140819
rgmd
RGM domain family, member D
chr5_+_37890521 0.22 ENSDART00000140207
tmprss4b
transmembrane protease, serine 4b
chr4_+_76426308 0.22 ENSDART00000180424
ENSDART00000159789
FP074874.1
zgc:172128

zgc:172128
chr15_+_11825366 0.20 ENSDART00000190042
prkd2
protein kinase D2
chr8_-_21142550 0.20 ENSDART00000143192
ENSDART00000186820
ENSDART00000135938
cpt2
carnitine palmitoyltransferase 2
chr10_-_43540196 0.19 ENSDART00000170891
si:ch73-215f7.1
si:ch73-215f7.1
chr6_-_49159207 0.19 ENSDART00000041942
tspan2a
tetraspanin 2a
chr15_-_762319 0.19 ENSDART00000154306
ENSDART00000157492
si:dkey-7i4.16
znf1011
si:dkey-7i4.16
zinc finger protein 1011
chr7_-_36358735 0.19 ENSDART00000188392
fto
fat mass and obesity associated
chr7_-_7766920 0.18 ENSDART00000173376
intu
inturned planar cell polarity protein
chr1_+_34701144 0.18 ENSDART00000150038
gtf2f2a
general transcription factor IIF, polypeptide 2a
chr2_+_53357953 0.18 ENSDART00000187577
celf5b
cugbp, Elav-like family member 5b
chr12_-_43428542 0.17 ENSDART00000192266
ptprea
protein tyrosine phosphatase, receptor type, E, a
chr24_-_25788841 0.15 ENSDART00000132235
klhl24b
kelch-like family member 24b
chr10_-_25816558 0.15 ENSDART00000017240
postna
periostin, osteoblast specific factor a
chr5_+_18047111 0.14 ENSDART00000132164
hira
histone cell cycle regulator a
chr21_+_51521 0.14 ENSDART00000007672
dmgdh
dimethylglycine dehydrogenase
chr3_+_41585298 0.14 ENSDART00000182370
card11
caspase recruitment domain family, member 11
chr20_-_29471577 0.13 ENSDART00000043382
grem1a
gremlin 1a, DAN family BMP antagonist
chr9_-_22310919 0.13 ENSDART00000108719
crygm2d10
crystallin, gamma M2d10
chr7_+_6385664 0.13 ENSDART00000173144
si:ch73-368j24.17
si:ch73-368j24.17
chr23_+_41679586 0.12 ENSDART00000067662
CU914487.1

chr5_-_38820046 0.11 ENSDART00000182886
cnot6l
CCR4-NOT transcription complex, subunit 6-like
chr2_-_732864 0.10 ENSDART00000168585
CU861459.1

chr14_-_17306261 0.10 ENSDART00000191747
jakmip1
janus kinase and microtubule interacting protein 1
chr21_-_1644414 0.09 ENSDART00000105736
ENSDART00000124904
zgc:152948
zgc:152948
chr1_-_45614318 0.09 ENSDART00000149725
atf7ip
activating transcription factor 7 interacting protein
chr4_+_76752707 0.08 ENSDART00000082121
ms4a17a.4
membrane-spanning 4-domains, subfamily A, member 17A.4
chr11_+_44804685 0.08 ENSDART00000163660
strn
striatin, calmodulin binding protein
chr17_+_41081512 0.08 ENSDART00000056742
babam2
BRISC and BRCA1 A complex member 2
chr2_-_32366989 0.07 ENSDART00000136758
ubtfl
upstream binding transcription factor, like
chr3_-_61387273 0.07 ENSDART00000156479
znf1143
zinc finger protein 1143
chr16_+_3185541 0.07 ENSDART00000024088
wdr21
WD repeat domain 21
chr22_+_2844865 0.06 ENSDART00000139123
si:dkey-20i20.4
si:dkey-20i20.4
chr10_-_36225729 0.06 ENSDART00000127677
or109-5
odorant receptor, family D, subfamily 109, member 5
chr22_+_9751117 0.04 ENSDART00000121827
BX664625.1

chr14_-_736575 0.04 ENSDART00000168611
tlr1
toll-like receptor 1
chr20_-_37287107 0.04 ENSDART00000076309
nmbr
neuromedin B receptor
chr24_-_20016817 0.04 ENSDART00000082201
ENSDART00000189448
slc22a13b
solute carrier family 22 member 13b
chr20_-_16849306 0.04 ENSDART00000131395
ENSDART00000027582
brms1lb
breast cancer metastasis-suppressor 1-like b
chr23_-_38497705 0.03 ENSDART00000109493
tshz2
teashirt zinc finger homeobox 2
chr17_-_15611744 0.03 ENSDART00000010496
fhl5
four and a half LIM domains 5
chr20_+_1960092 0.03 ENSDART00000191892
CABZ01103860.1

chr4_-_41712014 0.03 ENSDART00000138165
znf976
zinc finger protein 976
chr1_+_23408622 0.03 ENSDART00000140706
chrna9
cholinergic receptor, nicotinic, alpha 9
chr11_+_2398843 0.03 ENSDART00000126761
pip4k2cb
phosphatidylinositol-5-phosphate 4-kinase, type II, gamma b
chr20_+_5132138 0.03 ENSDART00000081351
ENSDART00000157685
cyp46a1.1
cytochrome P450, family 46, subfamily A, polypeptide 1, tandem duplicate 1
chr18_+_32979166 0.02 ENSDART00000163528
olfcg4
olfactory receptor C family, g4
chr6_-_28980756 0.02 ENSDART00000014661
glmnb
glomulin, FKBP associated protein b
chr22_-_10459880 0.02 ENSDART00000064801
ogn
osteoglycin
chr23_+_32335871 0.01 ENSDART00000149698
slc39a5
solute carrier family 39 (zinc transporter), member 5
chr9_+_50007556 0.01 ENSDART00000175587
slc38a11
solute carrier family 38, member 11
chr7_-_44970682 0.01 ENSDART00000144591
fam96b
family with sequence similarity 96, member B
chr9_+_41156818 0.01 ENSDART00000105764
ENSDART00000147052
stat4
signal transducer and activator of transcription 4
chr2_+_3881000 0.01 ENSDART00000081897
mpp7b
membrane protein, palmitoylated 7b (MAGUK p55 subfamily member 7)
chr8_-_8698607 0.01 ENSDART00000046712
zgc:86609
zgc:86609
chr18_-_19350792 0.01 ENSDART00000147902
megf11
multiple EGF-like-domains 11
chr25_-_24248000 0.00 ENSDART00000073527
spty2d1
SPT2 chromatin protein domain containing 1
chr6_-_18199062 0.00 ENSDART00000167513
ppp1r27b
protein phosphatase 1, regulatory subunit 27b
chr15_-_669476 0.00 ENSDART00000153687
ENSDART00000030603
si:ch211-210b2.2
si:ch211-210b2.2
chr11_-_34166960 0.00 ENSDART00000181571
atp13a3
ATPase 13A3

Network of associatons between targets according to the STRING database.

First level regulatory network of six6a+six6b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:1901836 regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901836)
0.3 1.2 GO:0051444 negative regulation of ligase activity(GO:0051352) negative regulation of ubiquitin-protein transferase activity(GO:0051444) negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.3 0.9 GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615)
0.3 1.1 GO:0006843 mitochondrial citrate transport(GO:0006843)
0.3 0.8 GO:0030857 negative regulation of epithelial cell differentiation(GO:0030857) regulation of endothelial cell differentiation(GO:0045601)
0.3 0.8 GO:0097237 cellular response to antibiotic(GO:0071236) cellular response to toxic substance(GO:0097237)
0.2 0.9 GO:0035279 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.2 1.4 GO:0044211 CTP salvage(GO:0044211)
0.1 1.0 GO:1901741 embryonic cleavage(GO:0040016) positive regulation of myoblast fusion(GO:1901741)
0.1 0.9 GO:0086091 regulation of heart rate by cardiac conduction(GO:0086091)
0.1 0.6 GO:0061687 detoxification of inorganic compound(GO:0061687)
0.1 0.8 GO:0018344 protein geranylgeranylation(GO:0018344)
0.1 0.3 GO:0019062 virion attachment to host cell(GO:0019062) adhesion of symbiont to host(GO:0044406) adhesion of symbiont to host cell(GO:0044650)
0.1 0.9 GO:0006561 proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129)
0.1 0.4 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.1 0.3 GO:0061187 regulation of chromatin silencing at rDNA(GO:0061187) negative regulation of chromatin silencing at rDNA(GO:0061188)
0.1 0.3 GO:0060912 cardiac cell fate specification(GO:0060912)
0.1 0.6 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.1 1.5 GO:0045807 positive regulation of endocytosis(GO:0045807)
0.1 2.0 GO:0006303 double-strand break repair via nonhomologous end joining(GO:0006303)
0.1 0.2 GO:0042245 RNA repair(GO:0042245)
0.1 0.7 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.0 0.5 GO:0006517 protein deglycosylation(GO:0006517)
0.0 0.2 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.0 0.3 GO:0043584 nose development(GO:0043584)
0.0 0.6 GO:0016486 peptide hormone processing(GO:0016486)
0.0 0.4 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.0 0.3 GO:0007220 Notch receptor processing(GO:0007220)
0.0 0.6 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.0 0.5 GO:0032094 response to food(GO:0032094)
0.0 0.3 GO:0006537 glutamate biosynthetic process(GO:0006537) glutamine catabolic process(GO:0006543)
0.0 0.6 GO:0014823 response to activity(GO:0014823)
0.0 0.3 GO:0045117 azole transport(GO:0045117)
0.0 0.8 GO:0036297 interstrand cross-link repair(GO:0036297)
0.0 0.1 GO:0038098 sequestering of BMP from receptor via BMP binding(GO:0038098)
0.0 0.4 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 1.1 GO:0008299 isoprenoid biosynthetic process(GO:0008299)
0.0 0.4 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.0 0.5 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.0 0.3 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0 1.7 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 0.1 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.0 0.8 GO:2000045 regulation of G1/S transition of mitotic cell cycle(GO:2000045)
0.0 1.0 GO:0030901 midbrain development(GO:0030901)
0.0 0.8 GO:0035987 endodermal cell differentiation(GO:0035987)
0.0 0.7 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.1 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)
0.0 0.4 GO:0008345 larval locomotory behavior(GO:0008345) larval behavior(GO:0030537)
0.0 0.6 GO:1902036 regulation of hematopoietic stem cell differentiation(GO:1902036)
0.0 0.3 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.0 0.8 GO:0051607 defense response to virus(GO:0051607)
0.0 0.8 GO:0045010 actin nucleation(GO:0045010)
0.0 0.2 GO:0008354 germ cell migration(GO:0008354)
0.0 0.3 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.0 0.9 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 0.3 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0008537 proteasome activator complex(GO:0008537)
0.2 0.8 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.1 0.9 GO:0005845 mRNA cap binding complex(GO:0005845)
0.1 0.4 GO:0070545 PeBoW complex(GO:0070545)
0.1 0.6 GO:0043034 costamere(GO:0043034)
0.1 0.3 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.1 0.3 GO:0070724 BMP receptor complex(GO:0070724)
0.0 0.9 GO:0043209 myelin sheath(GO:0043209)
0.0 0.3 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 0.3 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.6 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 0.2 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.0 0.5 GO:1902562 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 0.5 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.8 GO:0032592 integral component of mitochondrial membrane(GO:0032592)
0.0 0.4 GO:0043679 axon terminus(GO:0043679)
0.0 0.4 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0045145 single-stranded DNA 5'-3' exodeoxyribonuclease activity(GO:0045145)
0.2 0.9 GO:0070883 pre-miRNA binding(GO:0070883)
0.2 0.8 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.2 0.9 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.2 0.7 GO:0043998 H2A histone acetyltransferase activity(GO:0043998)
0.2 1.1 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.2 1.4 GO:0004849 uridine kinase activity(GO:0004849)
0.2 0.8 GO:0004908 interleukin-1 receptor activity(GO:0004908)
0.1 0.6 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.1 0.6 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.1 0.8 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 0.4 GO:1903136 cuprous ion binding(GO:1903136)
0.1 0.9 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.1 2.0 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 0.8 GO:0017091 AU-rich element binding(GO:0017091) mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 1.1 GO:0008266 poly(U) RNA binding(GO:0008266)
0.1 1.2 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.1 1.1 GO:0004659 prenyltransferase activity(GO:0004659)
0.0 1.2 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.2 GO:0043734 oxidative DNA demethylase activity(GO:0035516) DNA-N1-methyladenine dioxygenase activity(GO:0043734) RNA N6-methyladenosine dioxygenase activity(GO:1990931)
0.0 0.3 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.0 0.3 GO:1901474 azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.0 0.3 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 0.1 GO:0046997 oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor(GO:0046997)
0.0 0.8 GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153)
0.0 0.3 GO:0034452 dynactin binding(GO:0034452)
0.0 0.6 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.3 GO:0004359 glutaminase activity(GO:0004359)
0.0 0.2 GO:0016416 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.0 1.0 GO:0004707 MAP kinase activity(GO:0004707)
0.0 1.1 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.3 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.3 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.1 GO:0036122 BMP binding(GO:0036122)
0.0 0.4 GO:0005112 Notch binding(GO:0005112)
0.0 0.2 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.7 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.1 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.8 GO:0005178 integrin binding(GO:0005178)
0.0 0.6 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.2 GO:0015026 coreceptor activity(GO:0015026)
0.0 0.4 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.4 GO:0004629 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 2.3 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.8 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 0.3 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 1.2 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.3 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.3 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.0 0.2 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 1.1 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.8 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.3 REACTOME SIGNALING BY NOTCH4 Genes involved in Signaling by NOTCH4
0.0 0.3 REACTOME KINESINS Genes involved in Kinesins
0.0 0.2 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.6 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.4 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins