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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for smad3a+smad3b

Z-value: 0.63

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Transcription factors associated with smad3a+smad3b

Gene Symbol Gene ID Gene Info
smad3b
ENSDARG00000010207 SMAD family member 3b
smad3a
ENSDARG00000036096 SMAD family member 3a
smad3a
ENSDARG00000117146 SMAD family member 3a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
smad3adr11_v1_chr7_-_34149263_34149263-0.772.1e-04Click!
smad3bdr11_v1_chr18_+_19772874_19772874-0.542.2e-02Click!

Activity profile of smad3a+smad3b motif

Sorted Z-values of smad3a+smad3b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr16_-_32204470 0.78 ENSDART00000143928
rwdd1
RWD domain containing 1
chr19_+_627899 0.77 ENSDART00000148508
tert
telomerase reverse transcriptase
chr2_+_54641644 0.77 ENSDART00000027313
ndufv2
NADH dehydrogenase (ubiquinone) flavoprotein 2
chr8_+_39760258 0.76 ENSDART00000037914
cox6a1
cytochrome c oxidase subunit VIa polypeptide 1
chr3_+_13603272 0.71 ENSDART00000185084
hspbp1
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr11_-_8208464 0.65 ENSDART00000161283
pimr203
Pim proto-oncogene, serine/threonine kinase, related 203
chr19_-_8962884 0.64 ENSDART00000172582
ENSDART00000104657
mrps21
mitochondrial ribosomal protein S21
chr12_+_4712215 0.63 ENSDART00000152134
kansl1a
KAT8 regulatory NSL complex subunit 1a
chr20_-_4883673 0.63 ENSDART00000145540
ENSDART00000053877
zdhhc14
zinc finger, DHHC-type containing 14
chr5_+_62723233 0.62 ENSDART00000183718
nanos2
nanos homolog 2
chr2_-_20599315 0.62 ENSDART00000114199
si:ch211-267e7.3
si:ch211-267e7.3
chr21_+_26071874 0.60 ENSDART00000003001
ENSDART00000146573
rpl23a
ribosomal protein L23a
chr23_+_44614056 0.55 ENSDART00000188379
eno3
enolase 3, (beta, muscle)
chr13_-_3370638 0.55 ENSDART00000029649
prkn
parkin RBR E3 ubiquitin protein ligase
chr24_-_37698796 0.52 ENSDART00000172178
si:ch211-231f6.6
si:ch211-231f6.6
chr9_-_21369765 0.51 ENSDART00000132032
ift88
intraflagellar transport 88 homolog
chr22_-_28871787 0.50 ENSDART00000104828
gtpbp2b
GTP binding protein 2b
chr22_+_36914636 0.50 ENSDART00000150948
pimr205
Pim proto-oncogene, serine/threonine kinase, related 205
chr3_-_10779777 0.49 ENSDART00000153911
znf1004
zinc finger protein 1004
chr5_+_71999996 0.48 ENSDART00000179933
ENSDART00000187070
PLPP7 (1 of many)
phospholipid phosphatase 7 (inactive)
chr4_-_11737939 0.44 ENSDART00000150299
podxl
podocalyxin-like
chr3_-_58644920 0.44 ENSDART00000155953
dhrs7ca
dehydrogenase/reductase (SDR family) member 7Ca
chr20_-_27325258 0.43 ENSDART00000152917
asb2a.1
ankyrin repeat and SOCS box containing 2a, tandem duplicate 1
chr16_+_53603945 0.43 ENSDART00000083513
sacm1lb
SAC1 like phosphatidylinositide phosphatase b
chr23_-_35694461 0.43 ENSDART00000185884
tuba1c
tubulin, alpha 1c
chr21_-_26071773 0.42 ENSDART00000141382
rab34b
RAB34, member RAS oncogene family b
chr7_-_1504382 0.41 ENSDART00000172770
si:zfos-405g10.4
si:zfos-405g10.4
chr8_-_23194408 0.41 ENSDART00000141090
si:ch211-196c10.15
si:ch211-196c10.15
chr23_+_13928346 0.40 ENSDART00000155326
si:dkey-90a13.10
si:dkey-90a13.10
chr16_+_19013257 0.39 ENSDART00000144102
si:ch211-254p10.2
si:ch211-254p10.2
chr5_-_31716713 0.38 ENSDART00000131443
dpm2
dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
chr21_+_25533531 0.37 ENSDART00000134052
nlrc3l1
NLR family, CARD domain containing 3-like 1
chr1_+_52563298 0.37 ENSDART00000142465
abca1a
ATP-binding cassette, sub-family A (ABC1), member 1A
chr21_+_25533908 0.37 ENSDART00000185225
nlrc3l1
NLR family, CARD domain containing 3-like 1
chr1_-_57172294 0.37 ENSDART00000063774
rac1l
Rac family small GTPase 1, like
chr5_+_13385837 0.36 ENSDART00000191190
ccl19a.1
chemokine (C-C motif) ligand 19a, tandem duplicate 1
chr7_+_50448478 0.35 ENSDART00000098815
serinc4
serine incorporator 4
chr20_-_43495506 0.35 ENSDART00000170679
pimr132
Pim proto-oncogene, serine/threonine kinase, related 132
chr21_+_20903244 0.35 ENSDART00000186193
c7b
complement component 7b
chr13_+_17694845 0.35 ENSDART00000079778
ifit8
interferon-induced protein with tetratricopeptide repeats 8
chr3_-_28872756 0.34 ENSDART00000138840
eef2kmt
eukaryotic elongation factor 2 lysine methyltransferase
chr20_-_29683754 0.34 ENSDART00000130599
ENSDART00000015928
ENSDART00000131219
si:ch211-195d17.2
si:ch211-195d17.2
chr7_+_29053217 0.34 ENSDART00000134332
ENSDART00000137241
sinhcafl
SIN3-HDAC complex associated factor, like
chr25_-_35126024 0.33 ENSDART00000185109
HIST1H4I
zgc:165555
chr2_-_7605121 0.33 ENSDART00000182099
CABZ01021599.1

chr7_-_73834812 0.33 ENSDART00000128137
zgc:92594
zgc:92594
chr14_-_28052474 0.33 ENSDART00000172948
ENSDART00000135337
TSC22D3 (1 of many)
zgc:64189
si:ch211-220e11.3
zgc:64189
chr4_-_11577253 0.32 ENSDART00000144452
net1
neuroepithelial cell transforming 1
chr14_+_38786298 0.31 ENSDART00000164440
si:ch211-195b11.3
si:ch211-195b11.3
chr4_+_16787488 0.31 ENSDART00000143006
golt1ba
golgi transport 1Ba
chr4_-_14192254 0.30 ENSDART00000143804
pus7l
pseudouridylate synthase 7-like
chr22_-_10591876 0.30 ENSDART00000105846
si:dkey-42i9.8
si:dkey-42i9.8
chr9_-_7378566 0.29 ENSDART00000144003
slc23a3
solute carrier family 23, member 3
chr4_-_73709502 0.29 ENSDART00000170308
BX855614.3

chr12_-_17479078 0.29 ENSDART00000079115
papss2b
3'-phosphoadenosine 5'-phosphosulfate synthase 2b
chr15_+_2500510 0.29 ENSDART00000180329
wdr53
WD repeat domain 53
chr9_-_16853462 0.28 ENSDART00000160273
CT573248.2

chr12_-_20795867 0.28 ENSDART00000152835
ENSDART00000153424
nme2a
NME/NM23 nucleoside diphosphate kinase 2a
chr14_+_6546516 0.28 ENSDART00000097214
adam19b
ADAM metallopeptidase domain 19b
chr7_+_66822229 0.28 ENSDART00000112109
lyve1a
lymphatic vessel endothelial hyaluronic receptor 1a
chr1_+_54043563 0.27 ENSDART00000149760
triobpa
TRIO and F-actin binding protein a
chr25_+_35056619 0.27 ENSDART00000154389
HIST1H4J
histone cluster 1 H4 family member j
chr7_+_21180747 0.26 ENSDART00000185543
serpinh2
serine (or cysteine) peptidase inhibitor, clade H, member 2
chr21_+_18353703 0.25 ENSDART00000181396
ENSDART00000166359
si:ch73-287m6.1
si:ch73-287m6.1
chr2_-_22286828 0.25 ENSDART00000168653
fam110b
family with sequence similarity 110, member B
chr1_+_21731382 0.24 ENSDART00000054395
pax5
paired box 5
chr23_-_31396344 0.23 ENSDART00000112619
lca5
Leber congenital amaurosis 5
chr25_+_35065802 0.23 ENSDART00000182372
zgc:165555
zgc:165555
chr3_-_61203203 0.23 ENSDART00000171787
pvalb1
parvalbumin 1
chr17_+_12285285 0.22 ENSDART00000154336
pimr174
Pim proto-oncogene, serine/threonine kinase, related 174
chr22_+_36582963 0.22 ENSDART00000132181
armc9
armadillo repeat containing 9
chr2_-_19520324 0.22 ENSDART00000079877
pimr52
Pim proto-oncogene, serine/threonine kinase, related 52
chr16_-_2807527 0.22 ENSDART00000148927
tgfb2
transforming growth factor, beta 2
chr8_-_3346692 0.22 ENSDART00000057874
FUT9 (1 of many)
zgc:103510
chr6_+_9289802 0.20 ENSDART00000188650
kalrnb
kalirin RhoGEF kinase b
chr2_+_42236118 0.20 ENSDART00000114162
ENSDART00000141199
ftr02
finTRIM family, member 2
chr1_-_59139599 0.20 ENSDART00000152233
si:ch1073-110a20.3
si:ch1073-110a20.3
chr2_+_19578446 0.20 ENSDART00000164758
pimr50
Pim proto-oncogene, serine/threonine kinase, related 50
chr15_-_23793641 0.20 ENSDART00000122891
tmem97
transmembrane protein 97
chr14_+_17003757 0.19 ENSDART00000170208
limch1b
LIM and calponin homology domains 1b
chr14_-_40797117 0.19 ENSDART00000122369
elf1
E74-like ETS transcription factor 1
chr8_-_18203274 0.19 ENSDART00000134078
ENSDART00000180235
ENSDART00000080006
ENSDART00000125418
ENSDART00000142114
elovl8b
ELOVL fatty acid elongase 8b
chr17_+_9009098 0.19 ENSDART00000180856
akap6
A kinase (PRKA) anchor protein 6
chr12_-_22509069 0.18 ENSDART00000179755
ENSDART00000109707
neurl4
neuralized E3 ubiquitin protein ligase 4
chr3_-_62417677 0.18 ENSDART00000101888
sstr2b
somatostatin receptor 2b
chr4_-_18954001 0.18 ENSDART00000144814
si:dkey-31f5.8
si:dkey-31f5.8
chr3_+_24190207 0.18 ENSDART00000034762
prr15la
proline rich 15-like a
chr17_-_45009782 0.18 ENSDART00000123971
fam161b
family with sequence similarity 161, member B
chr6_+_49926115 0.17 ENSDART00000018523
ahcy
adenosylhomocysteinase
chr6_+_58698475 0.17 ENSDART00000056138
igsf8
immunoglobulin superfamily, member 8
chr16_+_19013018 0.16 ENSDART00000191526
si:ch211-254p10.2
si:ch211-254p10.2
chr23_+_42304602 0.16 ENSDART00000166004
cyp2aa11
cytochrome P450, family 2, subfamily AA, polypeptide 11
chr8_+_23194212 0.16 ENSDART00000028946
ENSDART00000186842
ENSDART00000137815
ENSDART00000136914
ENSDART00000144855
ENSDART00000182689
tpd52l2a
tumor protein D52-like 2a
chr8_+_29267093 0.16 ENSDART00000077647
grid2
glutamate receptor, ionotropic, delta 2
chr12_-_33805366 0.16 ENSDART00000030566
galk1
galactokinase 1
chr19_-_15281996 0.16 ENSDART00000103784
edn2
endothelin 2
chr17_+_12265095 0.16 ENSDART00000153812
pimr168
Pim proto-oncogene, serine/threonine kinase, related 168
chr25_-_35956344 0.16 ENSDART00000066987
mphosph6
M-phase phosphoprotein 6
chr16_+_5774977 0.15 ENSDART00000134202
ccka
cholecystokinin a
chr11_+_45448212 0.15 ENSDART00000173341
sos1
son of sevenless homolog 1 (Drosophila)
chr11_+_12175162 0.15 ENSDART00000125446
si:ch211-156l18.7
si:ch211-156l18.7
chr2_+_32796873 0.15 ENSDART00000077511
ccr9a
chemokine (C-C motif) receptor 9a
chr9_+_29616854 0.15 ENSDART00000033902
ENSDART00000143493
phf11
PHD finger protein 11
chr7_-_69121896 0.15 ENSDART00000130227
crispld2
cysteine-rich secretory protein LCCL domain containing 2
chr1_-_52494122 0.14 ENSDART00000131407
acy3.2
aspartoacylase (aminocyclase) 3, tandem duplicate 2
chr20_-_52199296 0.14 ENSDART00000131806
ENSDART00000143668
hlx1
H2.0-like homeo box 1 (Drosophila)
chr11_+_30310170 0.14 ENSDART00000127797
ugt1b3
UDP glucuronosyltransferase 1 family, polypeptide B3
chr15_-_41734639 0.14 ENSDART00000154230
ENSDART00000167443
ftr90
finTRIM family, member 90
chr21_-_17603182 0.14 ENSDART00000020048
ENSDART00000177270
gsna
gelsolin a
chr17_-_24564674 0.14 ENSDART00000105435
ENSDART00000135086
abch1
ATP-binding cassette, sub-family H, member 1
chr1_-_39943596 0.14 ENSDART00000149730
stox2a
storkhead box 2a
chr3_-_58189429 0.14 ENSDART00000156092
si:ch211-256e16.11
si:ch211-256e16.11
chr24_+_9744012 0.13 ENSDART00000129656
tmem108
transmembrane protein 108
chr25_-_173165 0.13 ENSDART00000193594
CABZ01114053.1

chr13_+_33298338 0.13 ENSDART00000131892
ENSDART00000143895
iqcc
IQ motif containing C
chr20_-_54377933 0.12 ENSDART00000182664
entpd5b
ectonucleoside triphosphate diphosphohydrolase 5b
chr18_-_7454422 0.12 ENSDART00000124709
pdp2
putative pyruvate dehydrogenase phosphatase isoenzyme 2
chr23_+_36052944 0.12 ENSDART00000103149
hoxc13a
homeobox C13a
chr8_-_13541514 0.12 ENSDART00000063834
zgc:86586
zgc:86586
chr17_+_14886828 0.12 ENSDART00000010507
ENSDART00000131052
ptger2a
prostaglandin E receptor 2a (subtype EP2)
chr8_-_52594111 0.12 ENSDART00000167667
si:ch73-199g24.2
si:ch73-199g24.2
chr22_-_4398069 0.12 ENSDART00000181893
kdm4b
lysine (K)-specific demethylase 4B
chr24_-_6038025 0.11 ENSDART00000077819
ENSDART00000139216
ftr61
finTRIM family, member 61
chr19_-_46775562 0.11 ENSDART00000187144
abrab
actin binding Rho activating protein b
chr6_-_50404732 0.11 ENSDART00000055510
romo1
reactive oxygen species modulator 1
chr17_+_27134806 0.11 ENSDART00000151901
rps6ka1
ribosomal protein S6 kinase a, polypeptide 1
chr18_+_20560442 0.11 ENSDART00000151990
wee2
WEE1 homolog 2 (S. pombe)
chr6_-_8498908 0.11 ENSDART00000149222
pglyrp2
peptidoglycan recognition protein 2
chr7_-_51528661 0.11 ENSDART00000174263
nhsl2
NHS-like 2
chr19_+_4068134 0.11 ENSDART00000158285
btr26
bloodthirsty-related gene family, member 26
chr13_+_10023256 0.11 ENSDART00000110035
srbd1
S1 RNA binding domain 1
chr9_-_43375205 0.11 ENSDART00000138436
znf385b
zinc finger protein 385B
chr23_-_2099350 0.11 ENSDART00000091532
ndnf
neuron-derived neurotrophic factor
chr23_-_21453614 0.11 ENSDART00000079274
her4.1
hairy-related 4, tandem duplicate 1
chr19_+_1097393 0.11 ENSDART00000168218
CABZ01111953.1

chr25_+_36315127 0.11 ENSDART00000191984
zgc:165555
zgc:165555
chr1_+_24366110 0.11 ENSDART00000139913
pimr178
Pim proto-oncogene, serine/threonine kinase, related 178
chr21_-_16399778 0.10 ENSDART00000136435
unc5da
unc-5 netrin receptor Da
chr25_-_29415369 0.10 ENSDART00000110774
ENSDART00000019183
ugt5a2
ugt5a1
UDP glucuronosyltransferase 5 family, polypeptide A2
UDP glucuronosyltransferase 5 family, polypeptide A1
chr24_+_36373588 0.10 ENSDART00000079101
map3k14b
mitogen-activated protein kinase kinase kinase 14b
chr9_-_41818760 0.10 ENSDART00000140601
si:dkeyp-30e7.2
si:dkeyp-30e7.2
chr20_+_35282682 0.10 ENSDART00000187199
fam49a
family with sequence similarity 49, member A
chr13_-_31397987 0.10 ENSDART00000008287
pgam1a
phosphoglycerate mutase 1a
chr12_+_4573696 0.10 ENSDART00000152534
si:dkey-94f20.4
si:dkey-94f20.4
chr5_+_38685089 0.10 ENSDART00000139743
si:dkey-58f10.10
si:dkey-58f10.10
chr25_-_20268027 0.10 ENSDART00000138763
dnajb9a
DnaJ (Hsp40) homolog, subfamily B, member 9a
chr11_+_8170948 0.10 ENSDART00000112127
ENSDART00000186267
dnase2b
deoxyribonuclease II beta
chr3_-_27784457 0.09 ENSDART00000019098
dnase1
deoxyribonuclease I
chr19_-_8604429 0.09 ENSDART00000151165
trim46b
tripartite motif containing 46b
chr7_+_2228276 0.09 ENSDART00000064294
si:dkey-187j14.4
si:dkey-187j14.4
chr11_+_30306606 0.09 ENSDART00000128276
ENSDART00000190222
ugt1b4
UDP glucuronosyltransferase 1 family, polypeptide B4
chr23_-_21463788 0.09 ENSDART00000079265
her4.4
hairy-related 4, tandem duplicate 4
chr1_-_22861348 0.09 ENSDART00000139412
SMIM18
si:dkey-92j12.6
chr10_+_23441488 0.09 ENSDART00000100783
si:ch73-122g19.1
si:ch73-122g19.1
chr2_+_47927026 0.09 ENSDART00000143023
ftr25
finTRIM family, member 25
chr5_+_24287927 0.09 ENSDART00000143563
zdhhc23a
zinc finger, DHHC-type containing 23a
chr17_-_51679784 0.09 ENSDART00000103374
atp6v1c2
ATPase H+ transporting V1 subunit C2
chr1_+_23784905 0.09 ENSDART00000171951
ENSDART00000188521
ENSDART00000183029
ENSDART00000187183
slit2
slit homolog 2 (Drosophila)
chr19_-_3167729 0.09 ENSDART00000110763
ENSDART00000145710
ENSDART00000074620
ENSDART00000105174
stm
starmaker
chr11_-_27874116 0.09 ENSDART00000180579
eif4g3a
eukaryotic translation initiation factor 4 gamma, 3a
chr1_+_59073203 0.08 ENSDART00000149937
ENSDART00000162201
MFAP4 (1 of many)
zgc:173915
si:zfos-2330d3.3
zgc:173915
chr13_-_23264724 0.08 ENSDART00000051886
si:dkey-103j14.5
si:dkey-103j14.5
chr4_+_33654247 0.08 ENSDART00000192537
si:dkey-84h14.1
si:dkey-84h14.1
chr6_+_6491013 0.08 ENSDART00000140827
bcl11ab
B cell CLL/lymphoma 11Ab
chr12_-_44016898 0.08 ENSDART00000175304
si:dkey-201i2.4
si:dkey-201i2.4
chr25_-_2081371 0.08 ENSDART00000104915
ENSDART00000156925
wnt7bb
wingless-type MMTV integration site family, member 7Bb
chr14_+_8504410 0.08 ENSDART00000123364
vegfba
vascular endothelial growth factor Ba
chr11_+_15890984 0.08 ENSDART00000158433
pank4
pantothenate kinase 4
chr3_-_33029426 0.08 ENSDART00000181287
CT583642.1

chr9_-_41153896 0.08 ENSDART00000059667
wdr75
WD repeat domain 75
chr14_-_22385779 0.08 ENSDART00000192211
ENSDART00000175309
fbxl3l
F-box and leucine-rich repeat protein 3, like
chr25_+_36345867 0.08 ENSDART00000186527
zgc:165555
zgc:165555
chr20_-_2619316 0.08 ENSDART00000185777
bub1
BUB1 mitotic checkpoint serine/threonine kinase
chr22_-_28373698 0.08 ENSDART00000157592
si:ch211-213c4.5
si:ch211-213c4.5
chr20_+_46213553 0.08 ENSDART00000100532
stx7l
syntaxin 7-like
chr18_+_13164325 0.08 ENSDART00000189057
tat
tyrosine aminotransferase
chr14_-_10762629 0.08 ENSDART00000061928
fgf16
fibroblast growth factor 16
chr6_+_28051978 0.07 ENSDART00000143218
si:ch73-194h10.2
si:ch73-194h10.2
chr3_+_52753416 0.07 ENSDART00000171185
gmip
GEM interacting protein
chr23_-_19230627 0.07 ENSDART00000007122
guca1b
guanylate cyclase activator 1B
chr20_+_46897504 0.07 ENSDART00000158124
si:ch73-21k16.1
si:ch73-21k16.1
chr10_-_24689725 0.07 ENSDART00000079566
si:ch211-287a12.9
si:ch211-287a12.9
chr15_+_38007237 0.07 ENSDART00000182271
CR944667.2

chr14_-_48348973 0.07 ENSDART00000185822
CABZ01080056.1

chr6_-_8498676 0.07 ENSDART00000148627
pglyrp2
peptidoglycan recognition protein 2
chr1_-_30366824 0.07 ENSDART00000125759
si:dkey-22o12.2
si:dkey-22o12.2
chr22_-_17499513 0.07 ENSDART00000105460
si:ch211-197g15.6
si:ch211-197g15.6
chr10_-_24416471 0.07 ENSDART00000135985
hephl1b
hephaestin-like 1b
chr8_-_3336273 0.07 ENSDART00000081160
zgc:173737
zgc:173737
chr19_-_10360188 0.07 ENSDART00000150933
si:ch211-232m10.6
si:ch211-232m10.6
chr21_-_27362938 0.07 ENSDART00000131297
rin1a
Ras and Rab interactor 1a
chr24_-_33291784 0.07 ENSDART00000124938
si:ch1073-406l10.2
si:ch1073-406l10.2
chr2_-_59157790 0.07 ENSDART00000192303
ENSDART00000159362
ftr32
finTRIM family, member 32
chr23_-_10914275 0.07 ENSDART00000112965
pdzrn3a
PDZ domain containing RING finger 3a
chr18_+_17611627 0.07 ENSDART00000046891
cetp
cholesteryl ester transfer protein, plasma
chr18_-_31227615 0.06 ENSDART00000003210
mc1r
melanocortin 1 receptor
chr19_+_7043634 0.06 ENSDART00000133954
mhc1uka
major histocompatibility complex class I UKA
chr13_+_2830574 0.06 ENSDART00000138143
si:ch211-233m11.1
si:ch211-233m11.1
chr16_-_53259409 0.06 ENSDART00000157080
si:ch211-269k10.4
si:ch211-269k10.4
chr10_-_36214582 0.06 ENSDART00000166471
or109-11
odorant receptor, family D, subfamily 109, member 11

Network of associatons between targets according to the STRING database.

First level regulatory network of smad3a+smad3b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0007571 age-dependent general metabolic decline(GO:0007571)
0.2 0.5 GO:0060785 regulation of apoptosis involved in tissue homeostasis(GO:0060785)
0.1 0.4 GO:0033632 cell-cell adhesion mediated by integrin(GO:0033631) regulation of cell-cell adhesion mediated by integrin(GO:0033632)
0.1 0.3 GO:0000103 sulfate assimilation(GO:0000103) purine ribonucleoside bisphosphate metabolic process(GO:0034035) purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428)
0.1 0.4 GO:0010874 regulation of cholesterol efflux(GO:0010874)
0.1 0.4 GO:0019348 dolichol metabolic process(GO:0019348)
0.1 1.3 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 0.6 GO:0034755 iron ion transmembrane transport(GO:0034755)
0.1 0.6 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889)
0.1 0.2 GO:0016045 detection of biotic stimulus(GO:0009595) detection of bacterium(GO:0016045) detection of other organism(GO:0098543) detection of external biotic stimulus(GO:0098581)
0.1 0.8 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 0.4 GO:0090385 phagosome-lysosome fusion(GO:0090385)
0.0 0.2 GO:0060584 regulation of systemic arterial blood pressure by endothelin(GO:0003100) vein smooth muscle contraction(GO:0014826) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.0 0.1 GO:0060631 regulation of meiosis I(GO:0060631)
0.0 0.3 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0 0.1 GO:1904184 regulation of pyruvate dehydrogenase activity(GO:1904182) positive regulation of pyruvate dehydrogenase activity(GO:1904184)
0.0 0.1 GO:0007414 axonal defasciculation(GO:0007414)
0.0 0.2 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.0 0.1 GO:0021543 pallium development(GO:0021543) cerebral cortex cell migration(GO:0021795) cerebral cortex tangential migration(GO:0021800) cerebral cortex tangential migration using cell-axon interactions(GO:0021824) substrate-dependent cerebral cortex tangential migration(GO:0021825) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) cerebral cortex development(GO:0021987)
0.0 0.2 GO:0060118 reflex(GO:0060004) vestibular reflex(GO:0060005) vestibular receptor cell differentiation(GO:0060114) vestibular receptor cell development(GO:0060118)
0.0 0.6 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 0.1 GO:0034695 response to prostaglandin E(GO:0034695) cellular response to prostaglandin E stimulus(GO:0071380)
0.0 0.2 GO:0006012 galactose metabolic process(GO:0006012)
0.0 0.1 GO:2000379 protein import into mitochondrial inner membrane(GO:0045039) positive regulation of reactive oxygen species metabolic process(GO:2000379)
0.0 0.2 GO:0061056 sclerotome development(GO:0061056)
0.0 0.1 GO:0034375 high-density lipoprotein particle remodeling(GO:0034375)
0.0 0.3 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.1 GO:0033345 asparagine catabolic process(GO:0006530) asparagine catabolic process via L-aspartate(GO:0033345)
0.0 0.1 GO:2000171 negative regulation of dendrite development(GO:2000171)
0.0 0.2 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
0.0 0.7 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.1 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.0 0.2 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.0 0.3 GO:1900107 regulation of nodal signaling pathway(GO:1900107)
0.0 0.3 GO:0046051 UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)
0.0 0.1 GO:0097106 postsynaptic density organization(GO:0097106)
0.0 0.2 GO:0051893 cell-substrate adherens junction assembly(GO:0007045) focal adhesion assembly(GO:0048041) regulation of focal adhesion assembly(GO:0051893) regulation of cell-substrate junction assembly(GO:0090109)
0.0 0.2 GO:0097534 lymphoid lineage cell migration(GO:0097534) lymphoid lineage cell migration into thymus(GO:0097535)
0.0 0.0 GO:0046048 ribonucleoside diphosphate catabolic process(GO:0009191) pyrimidine ribonucleoside diphosphate metabolic process(GO:0009193) UDP metabolic process(GO:0046048)
0.0 0.0 GO:0051228 mitotic spindle disassembly(GO:0051228) spindle disassembly(GO:0051230)
0.0 0.1 GO:0030262 apoptotic DNA fragmentation(GO:0006309) cellular component disassembly involved in execution phase of apoptosis(GO:0006921) apoptotic nuclear changes(GO:0030262)
0.0 0.1 GO:0006572 tyrosine catabolic process(GO:0006572)
0.0 0.1 GO:0021846 cell proliferation in forebrain(GO:0021846)
0.0 0.1 GO:0045299 otolith mineralization(GO:0045299)
0.0 0.3 GO:0001522 pseudouridine synthesis(GO:0001522)
0.0 0.2 GO:0048936 peripheral nervous system neuron axonogenesis(GO:0048936)
0.0 0.3 GO:0019835 cytolysis(GO:0019835)
0.0 0.3 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 0.1 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
0.0 0.1 GO:0060325 face morphogenesis(GO:0060325)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0000333 telomerase catalytic core complex(GO:0000333)
0.1 0.4 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.1 0.6 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 0.8 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.2 GO:0016460 myosin II complex(GO:0016460)
0.0 0.1 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0 0.4 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.6 GO:0044545 NSL complex(GO:0044545)
0.0 0.8 GO:0005844 polysome(GO:0005844)
0.0 0.5 GO:0097546 ciliary base(GO:0097546)
0.0 0.3 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.8 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.1 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.0 0.0 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 0.1 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0003721 telomerase RNA reverse transcriptase activity(GO:0003721)
0.1 0.4 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.1 0.3 GO:0004779 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.1 0.6 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.1 0.4 GO:0090556 phospholipid-translocating ATPase activity(GO:0004012) phosphatidylcholine-translocating ATPase activity(GO:0090554) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.1 0.7 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 0.6 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 0.6 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.1 0.2 GO:0016019 peptidoglycan receptor activity(GO:0016019)
0.1 0.2 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.2 GO:0032038 myosin head/neck binding(GO:0032028) myosin II head/neck binding(GO:0032034) myosin II heavy chain binding(GO:0032038)
0.0 0.2 GO:0031708 endothelin B receptor binding(GO:0031708)
0.0 0.2 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.0 0.1 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.0 0.8 GO:0016675 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.8 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.2 GO:0004994 somatostatin receptor activity(GO:0004994)
0.0 0.1 GO:0004980 melanocyte-stimulating hormone receptor activity(GO:0004980)
0.0 0.1 GO:0004082 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619)
0.0 0.1 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.0 0.3 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.7 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.0 GO:0004377 GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity(GO:0004377)
0.0 0.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.1 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.1 GO:0004046 aminoacylase activity(GO:0004046)
0.0 0.6 GO:0019843 rRNA binding(GO:0019843)
0.0 0.1 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.0 0.1 GO:0005042 netrin receptor activity(GO:0005042)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.9 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 0.5 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.2 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.4 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.6 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 1.5 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.4 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.8 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.0 0.2 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.1 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex