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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for sox8a+sox8b

Z-value: 0.26

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Transcription factors associated with sox8a+sox8b

Gene Symbol Gene ID Gene Info
sox8b
ENSDARG00000037782 SRY-box transcription factor 8b
sox8a
ENSDARG00000105301 SRY-box transcription factor 8a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
sox8adr11_v1_chr12_-_1085227_1085227-0.735.8e-04Click!
sox8bdr11_v1_chr3_-_62403550_62403550-0.718.8e-04Click!

Activity profile of sox8a+sox8b motif

Sorted Z-values of sox8a+sox8b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_-_27448606 0.57 ENSDART00000079251
vars2
valyl-tRNA synthetase 2, mitochondrial (putative)
chr12_-_11593436 0.55 ENSDART00000138954
plekha1b
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1b
chr12_-_33359052 0.53 ENSDART00000135943
slc16a3
solute carrier family 16 (monocarboxylate transporter), member 3
chr12_-_33359654 0.53 ENSDART00000001907
slc16a3
solute carrier family 16 (monocarboxylate transporter), member 3
chr22_-_817479 0.51 ENSDART00000123487
zgc:153675
zgc:153675
chr6_-_37743724 0.51 ENSDART00000149068
nipa2
non imprinted in Prader-Willi/Angelman syndrome 2 (human)
chr21_+_34088377 0.51 ENSDART00000170070
mtmr1b
myotubularin related protein 1b
chr21_+_34088110 0.50 ENSDART00000145123
ENSDART00000029599
ENSDART00000147519
mtmr1b
myotubularin related protein 1b
chr13_+_8892784 0.42 ENSDART00000075054
ENSDART00000143705
thada
thyroid adenoma associated
chr3_+_32663865 0.41 ENSDART00000190240
si:dkey-16l2.16
si:dkey-16l2.16
chr23_-_27235403 0.41 ENSDART00000134418
si:dkey-157g16.6
si:dkey-157g16.6
chr19_+_11432330 0.41 ENSDART00000188065
PQLC1
PQ loop repeat containing 1
chr16_+_46410520 0.39 ENSDART00000131072
rpz2
rapunzel 2
chr19_+_27448625 0.38 ENSDART00000052352
ppp1r11
protein phosphatase 1, regulatory (inhibitor) subunit 11
chr3_-_27647845 0.37 ENSDART00000151625
si:ch211-157c3.4
si:ch211-157c3.4
chr3_-_3413669 0.37 ENSDART00000113517
ENSDART00000179861
ENSDART00000115331
zgc:171446
zgc:171446
chr10_+_5268054 0.37 ENSDART00000114491
ror2
receptor tyrosine kinase-like orphan receptor 2
chr9_-_50001606 0.37 ENSDART00000161648
ENSDART00000168514
scn1a
sodium channel, voltage-gated, type I, alpha
chr2_+_15048410 0.36 ENSDART00000058484
cnn3b
calponin 3, acidic b
chr20_-_39789036 0.34 ENSDART00000086405
ENSDART00000098253
rnf217
ring finger protein 217
chr8_+_10862353 0.33 ENSDART00000140717
brpf3b
bromodomain and PHD finger containing, 3b
chr3_-_5067585 0.33 ENSDART00000169609
tefb
thyrotrophic embryonic factor b
chr11_+_13176568 0.31 ENSDART00000125371
ENSDART00000123257
mknk1
MAP kinase interacting serine/threonine kinase 1
chr15_-_43327911 0.31 ENSDART00000077386
prss16
protease, serine, 16 (thymus)
chr5_+_31214341 0.30 ENSDART00000133432
atp2a3
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
chr18_+_45666489 0.30 ENSDART00000180147
ENSDART00000151351
prrg4
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr14_+_38786298 0.30 ENSDART00000164440
si:ch211-195b11.3
si:ch211-195b11.3
chr2_+_24770435 0.30 ENSDART00000078854
mpv17l2
MPV17 mitochondrial membrane protein-like 2
chr11_-_43226255 0.29 ENSDART00000172929
sptbn1
spectrin, beta, non-erythrocytic 1
chr10_+_7709724 0.28 ENSDART00000097670
ggcx
gamma-glutamyl carboxylase
chr22_+_9522971 0.27 ENSDART00000110048
strip1
striatin interacting protein 1
chr3_+_39579393 0.26 ENSDART00000055170
cln3
ceroid-lipofuscinosis, neuronal 3
chr11_+_30254556 0.25 ENSDART00000182316
ppef1
protein phosphatase, EF-hand calcium binding domain 1
chr10_+_15967643 0.25 ENSDART00000136709
apbb1
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
chr7_+_25003851 0.25 ENSDART00000144526
naa40
N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae)
chr16_-_21047483 0.25 ENSDART00000136235
cbx3b
chromobox homolog 3b
chr7_+_17096281 0.24 ENSDART00000035558
htatip2
HIV-1 Tat interactive protein 2
chr8_-_7603516 0.23 ENSDART00000179826
ENSDART00000190153
irak1
interleukin-1 receptor-associated kinase 1
chr7_-_50410524 0.22 ENSDART00000083346
hypk
huntingtin interacting protein K
chr8_-_7603700 0.20 ENSDART00000137975
irak1
interleukin-1 receptor-associated kinase 1
chr12_+_34258139 0.20 ENSDART00000153127
socs3b
suppressor of cytokine signaling 3b
chr9_+_34952203 0.20 ENSDART00000121828
ENSDART00000142347
tfdp1a
transcription factor Dp-1, a
chr14_+_48862987 0.19 ENSDART00000167810
zgc:154054
zgc:154054
chr22_-_14262115 0.19 ENSDART00000168264
si:ch211-246m6.5
si:ch211-246m6.5
chr25_-_37248795 0.19 ENSDART00000087247
ENSDART00000154045
glg1a
golgi glycoprotein 1a
chr2_+_29925561 0.18 ENSDART00000163118
ENSDART00000183800
ENSDART00000180738
ENSDART00000139604
htr5aa
5-hydroxytryptamine (serotonin) receptor 5A, genome duplicate a
chr21_+_39673157 0.18 ENSDART00000100240
mrm3b
mitochondrial rRNA methyltransferase 3b
chr21_+_42717424 0.17 ENSDART00000166936
ENSDART00000172135
sh3pxd2b
SH3 and PX domains 2B
chr17_-_33707589 0.15 ENSDART00000124788
si:dkey-84k17.2
si:dkey-84k17.2
chr1_-_23308225 0.15 ENSDART00000137567
ENSDART00000008201
smim14
small integral membrane protein 14
chr11_-_18015534 0.14 ENSDART00000181953
qrich1
glutamine-rich 1
chr16_-_21047872 0.14 ENSDART00000131582
cbx3b
chromobox homolog 3b
chr1_+_6646529 0.12 ENSDART00000144641
ENSDART00000103701
ENSDART00000138919
ube2f
ubiquitin-conjugating enzyme E2F (putative)
chr20_+_54383838 0.12 ENSDART00000157737
lrfn5b
leucine rich repeat and fibronectin type III domain containing 5b
chr3_+_41726360 0.11 ENSDART00000154401
chst12a
carbohydrate (chondroitin 4) sulfotransferase 12a
chr4_+_6833735 0.11 ENSDART00000136355
dock4b
dedicator of cytokinesis 4b
chr20_-_29505863 0.10 ENSDART00000148278
klf11a
Kruppel-like factor 11a
chr9_+_17423941 0.10 ENSDART00000112884
ENSDART00000155233
kbtbd7
kelch repeat and BTB (POZ) domain containing 7
chr20_+_25936370 0.09 ENSDART00000141265
znf106b
zinc finger protein 106b
chr2_+_23222939 0.09 ENSDART00000026800
kifap3b
kinesin-associated protein 3b
chr11_-_30138299 0.08 ENSDART00000172106
scml2
Scm polycomb group protein like 2
chr20_-_3276339 0.08 ENSDART00000166831
rps6kc1
ribosomal protein S6 kinase polypeptide 1
chr7_+_52753067 0.08 ENSDART00000053814
mtfmt
mitochondrial methionyl-tRNA formyltransferase
chr9_-_3934963 0.07 ENSDART00000062336
ubr3
ubiquitin protein ligase E3 component n-recognin 3
chr21_-_43328056 0.07 ENSDART00000114955
sowahaa
sosondowah ankyrin repeat domain family member Aa
chr1_-_16688965 0.06 ENSDART00000079001
ENSDART00000178599
frg1
FSHD region gene 1
chr6_-_48347724 0.06 ENSDART00000046973
capza1a
capping protein (actin filament) muscle Z-line, alpha 1a
chr15_+_3125136 0.06 ENSDART00000130968
rcbtb2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr15_-_9419472 0.06 ENSDART00000122117
sacs
sacsin molecular chaperone
chr22_-_38621438 0.06 ENSDART00000098330
nppc
natriuretic peptide C
chr17_+_24687338 0.05 ENSDART00000135794
selenon
selenoprotein N
chr18_+_5917625 0.05 ENSDART00000169100
glg1b
golgi glycoprotein 1b
chr6_+_49926115 0.05 ENSDART00000018523
ahcy
adenosylhomocysteinase
chr10_-_14545658 0.05 ENSDART00000057865
ier3ip1
immediate early response 3 interacting protein 1
chr4_+_6833583 0.04 ENSDART00000165179
ENSDART00000186134
ENSDART00000174507
dock4b
dedicator of cytokinesis 4b
chr17_+_24604373 0.04 ENSDART00000082193
zmpste24
zinc metallopeptidase, STE24 homolog
chr9_-_43538328 0.04 ENSDART00000140526
znf385b
zinc finger protein 385B
chr4_+_40035116 0.04 ENSDART00000167808
BX649521.1

chr4_+_39766931 0.03 ENSDART00000138663
si:dkeyp-85d8.1
si:dkeyp-85d8.1
chr3_+_62327332 0.03 ENSDART00000158414
BX470259.1

chr9_-_23147026 0.03 ENSDART00000167266
lypd6b
LY6/PLAUR domain containing 6B
chr8_+_41238064 0.02 ENSDART00000111321
zgc:152830
zgc:152830
chr8_-_14052349 0.02 ENSDART00000135811
atp2b3a
ATPase plasma membrane Ca2+ transporting 3a
chr9_+_23714406 0.02 ENSDART00000189445
gypc
glycophorin C (Gerbich blood group)
chr9_+_41156818 0.02 ENSDART00000105764
ENSDART00000147052
stat4
signal transducer and activator of transcription 4
chr5_+_45139196 0.02 ENSDART00000113738
smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr5_-_6567464 0.02 ENSDART00000184985
tnks1bp1
tankyrase 1 binding protein 1
chr24_-_33873451 0.02 ENSDART00000159840
asic1c
acid-sensing (proton-gated) ion channel 1c
chr16_-_25607266 0.02 ENSDART00000192602
zgc:110410
zgc:110410
chr17_-_39880725 0.02 ENSDART00000184030
zmp:0000000545
zmp:0000000545
chr16_-_25606889 0.02 ENSDART00000077447
ENSDART00000131528
zgc:110410
zgc:110410
chr5_+_55265274 0.02 ENSDART00000131060
pcsk5a
proprotein convertase subtilisin/kexin type 5a
chr24_-_41220538 0.02 ENSDART00000150207
acvr2ba
activin A receptor type 2Ba
chr10_+_40629616 0.01 ENSDART00000147476
CR396590.9

chr8_-_46386024 0.01 ENSDART00000136602
ENSDART00000060919
ENSDART00000137472
qars
glutaminyl-tRNA synthetase
chr10_+_9595575 0.01 ENSDART00000091780
ENSDART00000184287
rc3h2
ring finger and CCCH-type domains 2
chr10_-_36214582 0.01 ENSDART00000166471
or109-11
odorant receptor, family D, subfamily 109, member 11
chr5_+_41146786 0.01 ENSDART00000175766
sub1b
SUB1 homolog, transcriptional regulator b
chr6_+_7322587 0.01 ENSDART00000065500
abcc4
ATP-binding cassette, sub-family C (CFTR/MRP), member 4
chr19_+_12801940 0.01 ENSDART00000040073
mc5ra
melanocortin 5a receptor
chr14_-_25452503 0.01 ENSDART00000148652
slc26a2
solute carrier family 26 (anion exchanger), member 2
chr10_-_7386475 0.00 ENSDART00000167963
nrg1
neuregulin 1
chr10_-_43334914 0.00 ENSDART00000146660
ENSDART00000190288
hapln1b
hyaluronan and proteoglycan link protein 1b
chr14_+_31721171 0.00 ENSDART00000173034
adgrg4a
adhesion G protein-coupled receptor G4a
chr10_-_22249444 0.00 ENSDART00000148831
fgf11b
fibroblast growth factor 11b
chr23_-_36418708 0.00 ENSDART00000132273
znf740b
zinc finger protein 740b

Network of associatons between targets according to the STRING database.

First level regulatory network of sox8a+sox8b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0061668 mitochondrial ribosome assembly(GO:0061668)
0.0 0.4 GO:0070498 interleukin-1-mediated signaling pathway(GO:0070498)
0.0 0.4 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0 0.3 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.0 0.3 GO:0015809 arginine transport(GO:0015809)
0.0 0.5 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.2 GO:0071800 podosome assembly(GO:0071800)
0.0 0.3 GO:0044154 histone H3-K14 acetylation(GO:0044154)
0.0 0.6 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.0 1.0 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.2 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.0 0.4 GO:1990798 pancreas regeneration(GO:1990798)
0.0 0.1 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.0 0.4 GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling(GO:0014068)
0.0 0.0 GO:0071586 CAAX-box protein processing(GO:0071586) CAAX-box protein maturation(GO:0080120)
0.0 1.1 GO:0015718 monocarboxylic acid transport(GO:0015718)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0008091 spectrin(GO:0008091)
0.0 0.3 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.1 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.2 GO:0002102 podosome(GO:0002102)
0.0 0.3 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.1 1.1 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 0.3 GO:0008488 gamma-glutamyl carboxylase activity(GO:0008488)
0.1 0.2 GO:0043998 H2A histone acetyltransferase activity(GO:0043998)
0.1 0.6 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.0 0.4 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.5 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.3 GO:0043994 H3 histone acetyltransferase activity(GO:0010484) histone acetyltransferase activity (H3-K23 specific)(GO:0043994)
0.0 0.3 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.2 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175) superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.6 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.3 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.1 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.4 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.2 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.0 0.2 GO:0001540 beta-amyloid binding(GO:0001540)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.4 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.3 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.4 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 0.3 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 0.6 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.3 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.3 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.3 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi