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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for sp1
Z-value: 2.23
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Transcription factors associated with sp1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| sp1 | dr11_v1_chr11_-_27821_27903 | 0.96 | 3.5e-10 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr13_-_17860307 Show fit | 10.99 |
ENSDART00000135920
ENSDART00000054579 |
membrane-associated ring finger (C3HC4) 8 |
|
| chr8_-_410728 Show fit | 9.55 |
ENSDART00000151255
|
tripartite motif containing 36 |
|
| chr18_-_127558 Show fit | 8.96 |
ENSDART00000149556
|
transient receptor potential cation channel, subfamily M, member 7 |
|
| chr8_-_410199 Show fit | 7.29 |
ENSDART00000091177
ENSDART00000122979 ENSDART00000151331 ENSDART00000151155 |
tripartite motif containing 36 |
|
| chr18_-_127873 Show fit | 6.80 |
ENSDART00000148490
|
transient receptor potential cation channel, subfamily M, member 7 |
|
| chr8_-_20230559 Show fit | 6.22 |
ENSDART00000193677
|
MLLT1, super elongation complex subunit a |
|
| chr7_-_19332293 Show fit | 6.06 |
ENSDART00000169668
ENSDART00000137575 ENSDART00000090406 |
dedicator of cytokinesis 11 |
|
| chr3_+_51684963 Show fit | 6.01 |
ENSDART00000091180
ENSDART00000183711 ENSDART00000159493 |
BAI1-associated protein 2a |
|
| chr16_-_7793457 Show fit | 5.86 |
ENSDART00000113483
|
tripartite motif containing 71, E3 ubiquitin protein ligase |
|
| chr17_-_23709347 Show fit | 5.80 |
ENSDART00000124661
|
3'-phosphoadenosine 5'-phosphosulfate synthase 2a |
Network of associatons between targets according to the STRING database.
First level regulatory network of sp1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.3 | 15.8 | GO:0010961 | cellular magnesium ion homeostasis(GO:0010961) |
| 0.1 | 13.5 | GO:0018105 | peptidyl-serine phosphorylation(GO:0018105) |
| 0.7 | 11.5 | GO:0035803 | binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344) |
| 2.7 | 11.0 | GO:0002495 | antigen processing and presentation of peptide antigen via MHC class II(GO:0002495) |
| 0.1 | 9.6 | GO:0031098 | stress-activated protein kinase signaling cascade(GO:0031098) |
| 0.1 | 9.0 | GO:0048916 | posterior lateral line development(GO:0048916) |
| 1.1 | 8.8 | GO:2000251 | positive regulation of actin cytoskeleton reorganization(GO:2000251) |
| 0.1 | 8.2 | GO:0051693 | actin filament capping(GO:0051693) |
| 0.1 | 8.0 | GO:0061640 | cytoskeleton-dependent cytokinesis(GO:0061640) |
| 0.8 | 7.3 | GO:0007080 | mitotic metaphase plate congression(GO:0007080) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 23.7 | GO:0005923 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
| 0.0 | 20.5 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.2 | 15.5 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.0 | 13.7 | GO:0012505 | endomembrane system(GO:0012505) |
| 0.1 | 10.4 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.5 | 10.1 | GO:0034993 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 0.0 | 9.5 | GO:0005654 | nucleoplasm(GO:0005654) |
| 0.0 | 9.3 | GO:0005730 | nucleolus(GO:0005730) |
| 0.5 | 8.2 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.1 | 8.2 | GO:0000922 | spindle pole(GO:0000922) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 18.2 | GO:0008270 | zinc ion binding(GO:0008270) |
| 0.1 | 13.8 | GO:0003774 | motor activity(GO:0003774) |
| 1.0 | 13.7 | GO:0047631 | ADP-ribose diphosphatase activity(GO:0047631) |
| 1.0 | 11.5 | GO:0035804 | structural constituent of egg coat(GO:0035804) |
| 0.0 | 11.3 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.0 | 11.1 | GO:0003712 | transcription factor activity, transcription factor binding(GO:0000989) transcription cofactor activity(GO:0003712) |
| 0.0 | 11.1 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.2 | 10.9 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.1 | 10.9 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.7 | 10.0 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 17.1 | PID FOXO PATHWAY | FoxO family signaling |
| 0.2 | 10.3 | PID P73PATHWAY | p73 transcription factor network |
| 0.1 | 10.2 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.3 | 9.9 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.3 | 9.0 | ST P38 MAPK PATHWAY | p38 MAPK Pathway |
| 0.4 | 8.8 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.2 | 8.3 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.2 | 5.4 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.2 | 4.9 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 4.6 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 19.0 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 1.3 | 10.7 | REACTOME ACYL CHAIN REMODELLING OF PG | Genes involved in Acyl chain remodelling of PG |
| 0.4 | 9.8 | REACTOME ELONGATION ARREST AND RECOVERY | Genes involved in Elongation arrest and recovery |
| 0.2 | 9.4 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.1 | 9.1 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.7 | 7.3 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.3 | 6.9 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 6.0 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.1 | 6.0 | REACTOME DIABETES PATHWAYS | Genes involved in Diabetes pathways |
| 0.6 | 5.6 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |