ISMARA results: spi1a+spi1b

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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for spi1a+spi1b

Z-value: 3.26

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Transcription factors associated with spi1a+spi1b

Gene Symbol	Gene ID	Gene Info
spi1b NCBI UniProt	ENSDARG00000000767	Spi-1 proto-oncogene b
spi1a NCBI UniProt	ENSDARG00000067797	Spi-1 proto-oncogene a

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
spi1b	dr11_v1_chr7_-_32659048_32659048	-0.84	1.3e-05	Click!
spi1a	dr11_v1_chr25_+_35553542_35553542	-0.77	1.8e-04	Click!

Activity profile of spi1a+spi1b motif

Sorted Z-values of spi1a+spi1b motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr15_+_12435975 Show fit	11.38	ENSDART00000168011	tmprss4a NCBI UniProt Show fit	transmembrane protease, serine 4a
chr15_+_12436220 Show fit	11.25	ENSDART00000169894	tmprss4a NCBI UniProt Show fit	transmembrane protease, serine 4a
chr18_+_15937610 Show fit	8.31	ENSDART00000061134 ENSDART00000154505	itpr2 NCBI UniProt Show fit	inositol 1,4,5-trisphosphate receptor, type 2
chr7_-_26603743 Show fit	8.19	ENSDART00000099003	plscr3b NCBI UniProt Show fit	phospholipid scramblase 3b
chr16_-_24832038 Show fit	8.05	ENSDART00000153731	si:dkey-79d12.5 NCBI UniProt Show fit	si:dkey-79d12.5
chr12_-_17686404 Show fit	7.47	ENSDART00000079065	ccz1 NCBI UniProt Show fit	CCZ1 homolog, vacuolar protein trafficking and biogenesis associated
chr8_+_52442622 Show fit	6.96	ENSDART00000012758	zgc:77112 NCBI UniProt Show fit	zgc:77112
chr24_-_31904924 Show fit	6.93	ENSDART00000156060 ENSDART00000129741 ENSDART00000154276	si:ch73-78o10.1 NCBI UniProt Show fit	si:ch73-78o10.1
chr8_-_32385989 Show fit	6.74	ENSDART00000143716 ENSDART00000098850	lipg NCBI UniProt Show fit	lipase, endothelial
chr13_-_17943135 Show fit	6.52	ENSDART00000176027	march8 NCBI UniProt Show fit	membrane-associated ring finger (C3HC4) 8

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of spi1a+spi1b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	22.2	GO:0018105	peptidyl-serine phosphorylation(GO:0018105)
0.7	16.3	GO:0032885	regulation of polysaccharide biosynthetic process(GO:0032885)
1.2	16.2	GO:0002084	protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.5	14.1	GO:0006515	misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.3	13.3	GO:0071166	ribonucleoprotein complex localization(GO:0071166)
0.4	12.7	GO:0017121	phospholipid scrambling(GO:0017121)
0.1	11.0	GO:0061640	cytoskeleton-dependent cytokinesis(GO:0061640)
2.7	10.9	GO:0002495	antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.1	10.3	GO:0045930	negative regulation of mitotic cell cycle(GO:0045930)
0.5	9.2	GO:0035803	binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)

Showing 1 to 10 of 408 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	66.8	GO:0005783	endoplasmic reticulum(GO:0005783)
0.2	40.1	GO:0000323	lytic vacuole(GO:0000323)
0.0	31.6	GO:0005794	Golgi apparatus(GO:0005794)
0.2	19.1	GO:0016323	basolateral plasma membrane(GO:0016323)
0.1	17.4	GO:0005923	bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.3	14.7	GO:0031901	early endosome membrane(GO:0031901)
0.2	14.0	GO:0005769	early endosome(GO:0005769)
0.4	13.8	GO:0032156	septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.8	12.8	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.1	10.2	GO:0099572	postsynaptic specialization(GO:0099572)

Showing 1 to 10 of 164 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	21.9	GO:0060090	binding, bridging(GO:0060090)
1.0	20.9	GO:0098599	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.3	19.5	GO:0005044	scavenger receptor activity(GO:0005044)
1.2	13.3	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.0	13.3	GO:0005085	guanyl-nucleotide exchange factor activity(GO:0005085)
0.9	12.9	GO:0051117	ATPase binding(GO:0051117)
0.9	12.8	GO:2001069	glycogen binding(GO:2001069)
0.1	12.3	GO:0003714	transcription corepressor activity(GO:0003714)
0.0	11.8	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)
0.4	11.0	GO:0042287	MHC protein binding(GO:0042287)

Showing 1 to 10 of 309 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	17.1	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.3	14.1	PID PLK1 PATHWAY	PLK1 signaling events
0.3	12.8	PID AURORA B PATHWAY	Aurora B signaling
0.3	10.3	PID PI3KCI PATHWAY	Class I PI3K signaling events
1.1	8.4	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.4	7.5	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.3	7.5	ST TUMOR NECROSIS FACTOR PATHWAY	Tumor Necrosis Factor Pathway.
0.4	7.0	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
0.3	6.8	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.2	6.6	PID ATM PATHWAY	ATM pathway

Showing 1 to 10 of 61 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	14.3	REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE	Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.5	13.8	REACTOME LYSOSOME VESICLE BIOGENESIS	Genes involved in Lysosome Vesicle Biogenesis
0.7	11.9	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
1.0	8.3	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.1	7.4	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
0.6	7.2	REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.2	7.2	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.3	6.5	REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	Genes involved in Synthesis of PIPs at the Golgi membrane
0.5	6.4	REACTOME ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS	Genes involved in Activation of NMDA receptor upon glutamate binding and postsynaptic events
0.7	6.3	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine

Showing 1 to 10 of 108 entries

Results for spi1a+spi1b

Z-value: 3.26

Motif logo

Transcription factors associated with spi1a+spi1b

Activity-expression correlation:

Activity profile of spi1a+spi1b motif

Sorted Z-values of spi1a+spi1b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of spi1a+spi1b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: