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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for stat5a+stat5b

Z-value: 0.62

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Transcription factors associated with stat5a+stat5b

Gene Symbol Gene ID Gene Info
stat5a
ENSDARG00000019392 signal transducer and activator of transcription 5a
stat5b
ENSDARG00000055588 signal transducer and activator of transcription 5b
stat5a
ENSDARG00000113871 signal transducer and activator of transcription 5a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
stat5adr11_v1_chr3_+_17251542_17251542-0.762.9e-04Click!
stat5bdr11_v1_chr12_-_13650344_13650472-0.561.7e-02Click!

Activity profile of stat5a+stat5b motif

Sorted Z-values of stat5a+stat5b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr22_+_36914636 2.99 ENSDART00000150948
pimr205
Pim proto-oncogene, serine/threonine kinase, related 205
chr16_+_34523515 2.79 ENSDART00000041007
stmn1b
stathmin 1b
chr8_-_47212686 2.27 ENSDART00000040370
pimr189
Pim proto-oncogene, serine/threonine kinase, related 189
chr3_+_55100045 2.14 ENSDART00000113098
hbaa1
hemoglobin, alpha adult 1
chr8_-_46060685 2.13 ENSDART00000121902
pimr188
Pim proto-oncogene, serine/threonine kinase, related 188
chr15_-_25083200 1.91 ENSDART00000156053
pimr191
Pim proto-oncogene, serine/threonine kinase, related 191
chr15_-_25010400 1.89 ENSDART00000155236
si:ch211-198e20.10
si:ch211-198e20.10
chr11_-_17964525 1.65 ENSDART00000018948
cishb
cytokine inducible SH2-containing protein b
chr15_-_25039083 1.64 ENSDART00000154409
pimr190
Pim proto-oncogene, serine/threonine kinase, related 190
chr17_+_46864116 1.43 ENSDART00000156250
pimr27
Pim proto-oncogene, serine/threonine kinase, related 27
chr22_+_7480465 1.40 ENSDART00000034545
CELA1 (1 of many)
zgc:92745
chr16_+_25126935 1.31 ENSDART00000058945
zgc:92590
zgc:92590
chr18_-_48558420 1.23 ENSDART00000058987
kcnj1a.1
potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 1
chr17_-_24521382 1.14 ENSDART00000092948
peli1b
pellino E3 ubiquitin protein ligase 1b
chr11_+_30321116 1.14 ENSDART00000187921
ENSDART00000127075
ugt1b1
UDP glucuronosyltransferase 1 family, polypeptide B1
chr6_+_16895685 1.06 ENSDART00000154090
pimr28
Pim proto-oncogene, serine/threonine kinase, related 28
chr20_+_25586099 1.06 ENSDART00000063122
ENSDART00000134047
cyp2p10
cytochrome P450, family 2, subfamily P, polypeptide 10
chr6_+_16870004 1.02 ENSDART00000154794
pimr21
Pim proto-oncogene, serine/threonine kinase, related 21
chr6_+_45934682 0.97 ENSDART00000103489
cenps
centromere protein S
chr2_+_22659787 0.95 ENSDART00000043956
zgc:161973
zgc:161973
chr12_+_22680115 0.91 ENSDART00000152879
ablim2
actin binding LIM protein family, member 2
chr22_+_2937485 0.90 ENSDART00000082222
ENSDART00000135507
ENSDART00000143258
cep19
centrosomal protein 19
chr4_-_57572054 0.77 ENSDART00000158610
pimr168
Pim proto-oncogene, serine/threonine kinase, related 168
chr4_-_18595525 0.76 ENSDART00000049061
cdkn1ba
cyclin-dependent kinase inhibitor 1Ba
chr1_-_44025066 0.74 ENSDART00000148932
si:ch73-109d9.1
si:ch73-109d9.1
chr17_-_46817295 0.69 ENSDART00000155904
pimr24
Pim proto-oncogene, serine/threonine kinase, related 24
chr16_+_9762261 0.69 ENSDART00000020654
psmd4b
proteasome 26S subunit, non-ATPase 4b
chr17_+_12255642 0.68 ENSDART00000155175
pimr175
Pim proto-oncogene, serine/threonine kinase, related 175
chr4_-_12323228 0.68 ENSDART00000081089
il17ra1a
interleukin 17 receptor A1a
chr13_+_6092135 0.67 ENSDART00000162738
fam120b
family with sequence similarity 120B
chr17_-_24439672 0.66 ENSDART00000155020
wdpcp
WD repeat containing planar cell polarity effector
chr4_-_1497384 0.64 ENSDART00000093236
zmp:0000000711
zmp:0000000711
chr17_-_46933567 0.61 ENSDART00000157274
pimr25
Pim proto-oncogene, serine/threonine kinase, related 25
chr17_-_26604946 0.61 ENSDART00000087062
fam149b1
family with sequence similarity 149, member B1
chr15_-_41290415 0.61 ENSDART00000152157
si:dkey-75b17.1
si:dkey-75b17.1
chr4_+_47174366 0.59 ENSDART00000170732
si:dkey-26m3.1
si:dkey-26m3.1
chr6_-_18393476 0.58 ENSDART00000168309
trim25
tripartite motif containing 25
chr22_-_16180467 0.58 ENSDART00000171331
ENSDART00000185607
vcam1b
vascular cell adhesion molecule 1b
chr4_-_49952636 0.57 ENSDART00000157941
si:dkey-156k2.3
si:dkey-156k2.3
chr20_-_54508650 0.56 ENSDART00000147642
CABZ01118770.1

chr15_-_2010926 0.55 ENSDART00000155688
dock10
dedicator of cytokinesis 10
chr14_+_6953244 0.55 ENSDART00000159470
rack1
receptor for activated C kinase 1
chr7_+_26029672 0.53 ENSDART00000101126
alox12
arachidonate 12-lipoxygenase
chr2_+_44426609 0.53 ENSDART00000112711
ENSDART00000154188
kcnab1b
potassium voltage-gated channel, shaker-related subfamily, beta member 1 b
chr15_-_32383529 0.53 ENSDART00000028349
c4
complement component 4
chr1_-_7582859 0.51 ENSDART00000110696
mxb
myxovirus (influenza) resistance B
chr9_-_49860756 0.50 ENSDART00000044270
ttc21b
tetratricopeptide repeat domain 21B
chr10_-_43568239 0.50 ENSDART00000131731
ENSDART00000097433
ENSDART00000131309
mef2ca
myocyte enhancer factor 2ca
chr25_+_31323978 0.49 ENSDART00000067030
lsp1
lymphocyte-specific protein 1
chr24_+_39576071 0.49 ENSDART00000147137
si:dkey-161j23.6
si:dkey-161j23.6
chr3_-_45281350 0.47 ENSDART00000020168
kctd5a
potassium channel tetramerization domain containing 5a
chr6_-_17266221 0.46 ENSDART00000155448
pimr18
Pim proto-oncogene, serine/threonine kinase, related 18
chr20_+_52458765 0.46 ENSDART00000057980
tsta3
tissue specific transplantation antigen P35B
chr5_+_32141790 0.44 ENSDART00000041504
tescb
tescalcin b
chr15_+_37412883 0.43 ENSDART00000156474
zbtb32
zinc finger and BTB domain containing 32
chr25_+_10793478 0.43 ENSDART00000058339
ENSDART00000134923
ap3s2
adaptor-related protein complex 3, sigma 2 subunit
chr2_-_51794472 0.43 ENSDART00000186652
BX908782.3

chr13_-_49819027 0.41 ENSDART00000067824
b3galnt2
beta-1,3-N-acetylgalactosaminyltransferase 2
chr22_-_26005894 0.41 ENSDART00000105088
pdgfaa
platelet-derived growth factor alpha polypeptide a
chr8_+_19548985 0.41 ENSDART00000123104
notch2
notch 2
chr6_-_16804001 0.40 ENSDART00000155398
pimr40
Pim proto-oncogene, serine/threonine kinase, related 40
chr12_-_46959990 0.40 ENSDART00000084557
lhpp
phospholysine phosphohistidine inorganic pyrophosphate phosphatase
chr4_-_685412 0.39 ENSDART00000168167
rtcb
RNA 2',3'-cyclic phosphate and 5'-OH ligase
chr6_-_16735402 0.39 ENSDART00000154216
pimr44
Pim proto-oncogene, serine/threonine kinase, related 44
chr19_+_7759354 0.39 ENSDART00000151400
ubap2l
ubiquitin associated protein 2-like
chr7_+_17303944 0.39 ENSDART00000163505
ENSDART00000162169
ENSDART00000161291
nitr9
novel immune-type receptor 9
chr19_+_25504645 0.37 ENSDART00000143292
col28a1a
collagen, type XXVIII, alpha 1a
chr21_-_27010796 0.37 ENSDART00000065398
ENSDART00000144342
ENSDART00000126542
ppp1r14ba
protein phosphatase 1, regulatory (inhibitor) subunit 14Ba
chr24_+_13635108 0.37 ENSDART00000183008
trpa1b
transient receptor potential cation channel, subfamily A, member 1b
chr6_-_17052116 0.36 ENSDART00000156825
pimr45
Pim proto-oncogene, serine/threonine kinase, related 45
chr25_+_6186823 0.35 ENSDART00000153526
oaz2a
ornithine decarboxylase antizyme 2a
chr21_-_32284532 0.35 ENSDART00000190676
clk4b
CDC-like kinase 4b
chr4_+_11479705 0.34 ENSDART00000019458
ENSDART00000150587
ENSDART00000139370
ENSDART00000135826
asb13a.1
ankyrin repeat and SOCS box containing 13a, tandem duplicate 1
chr4_+_34599803 0.33 ENSDART00000134088
pimr168
Pim proto-oncogene, serine/threonine kinase, related 168
chr1_-_9195629 0.32 ENSDART00000143587
ENSDART00000192174
ern2
endoplasmic reticulum to nucleus signaling 2
chr4_-_57571688 0.31 ENSDART00000160179
pimr168
Pim proto-oncogene, serine/threonine kinase, related 168
chr24_+_13635387 0.29 ENSDART00000105997
trpa1b
transient receptor potential cation channel, subfamily A, member 1b
chr5_-_42883761 0.29 ENSDART00000167374
BX323596.2

chr15_-_32383340 0.29 ENSDART00000185632
c4
complement component 4
chr22_-_26100282 0.28 ENSDART00000166075
pdgfaa
platelet-derived growth factor alpha polypeptide a
chr10_-_8434816 0.26 ENSDART00000108643
tctn1
tectonic family member 1
chr2_-_14793343 0.25 ENSDART00000132264
si:ch73-366i20.1
si:ch73-366i20.1
chr8_-_45838481 0.24 ENSDART00000148206
ENSDART00000170485
ogdha
oxoglutarate (alpha-ketoglutarate) dehydrogenase a (lipoamide)
chr17_-_26604549 0.24 ENSDART00000174773
fam149b1
family with sequence similarity 149, member B1
chr18_-_49318823 0.24 ENSDART00000098419
sb:cb81
sb:cb81
chr16_+_34522977 0.23 ENSDART00000144069
paqr7b
progestin and adipoQ receptor family member VII, b
chr8_-_28342487 0.22 ENSDART00000108508
kdm5bb
lysine (K)-specific demethylase 5Bb
chr2_-_49978227 0.21 ENSDART00000142835
hecw1b
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1b
chr2_-_42035250 0.21 ENSDART00000056460
ENSDART00000140788
gbp1
guanylate binding protein 1
chr20_+_17581881 0.21 ENSDART00000182832
cdh2
cadherin 2, type 1, N-cadherin (neuronal)
chr1_+_230363 0.20 ENSDART00000153285
tfdp1b
transcription factor Dp-1, b
chr15_-_3282220 0.20 ENSDART00000092942
slc25a15a
solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15a
chr24_+_25032340 0.20 ENSDART00000005845
mtmr6
myotubularin related protein 6
chr25_-_30394746 0.19 ENSDART00000185346
si:ch211-93f2.1
si:ch211-93f2.1
chr1_-_10647484 0.19 ENSDART00000164541
ENSDART00000188958
ENSDART00000190904
si:dkey-31e10.1
si:dkey-31e10.1
chr15_+_29088426 0.18 ENSDART00000187290
si:ch211-137a8.4
si:ch211-137a8.4
chr16_-_41787421 0.17 ENSDART00000147210
si:dkey-199f5.8
si:dkey-199f5.8
chr18_+_17660402 0.15 ENSDART00000143475
cpne2
copine II
chr6_-_43677125 0.15 ENSDART00000150128
foxp1b
forkhead box P1b
chr9_+_219124 0.14 ENSDART00000161484
map3k12
mitogen-activated protein kinase kinase kinase 12
chr1_-_10647307 0.13 ENSDART00000103548
si:dkey-31e10.1
si:dkey-31e10.1
chr11_-_34518362 0.13 ENSDART00000188223
pik3ca
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
chr17_-_23631400 0.13 ENSDART00000079563
fas
Fas cell surface death receptor
chr16_+_10841163 0.11 ENSDART00000065467
dedd1
death effector domain-containing 1
chr10_-_24868581 0.11 ENSDART00000193055
CABZ01058107.1

chr17_-_6536305 0.10 ENSDART00000154855
cenpo
centromere protein O
chr19_-_32804535 0.10 ENSDART00000175613
ENSDART00000052098
nt5c1aa
5'-nucleotidase, cytosolic IAa
chr4_+_57580303 0.10 ENSDART00000166492
ENSDART00000103025
ENSDART00000170786
il17ra1b
il17ra2
interleukin 17 receptor A1b
interleukin 17 receptor A2
chr5_+_29160324 0.09 ENSDART00000137324
dpp7
dipeptidyl-peptidase 7
chr9_+_1313418 0.09 ENSDART00000191361
casp8l2
caspase 8, apoptosis-related cysteine peptidase, like 2
chr5_-_42071505 0.08 ENSDART00000137224
ENSDART00000193721
cxcl11.7
cenpv
chemokine (C-X-C motif) ligand 11, duplicate 7
centromere protein V
chr2_+_7192966 0.08 ENSDART00000142735
si:ch211-13f8.1
si:ch211-13f8.1
chr18_+_6479963 0.08 ENSDART00000092752
ENSDART00000136333
wash1
WAS protein family homolog 1
chr3_-_46818001 0.07 ENSDART00000166505
elavl3
ELAV like neuron-specific RNA binding protein 3
chr12_-_30338779 0.07 ENSDART00000192511
vwa2
von Willebrand factor A domain containing 2
chr20_+_37294112 0.07 ENSDART00000076293
ENSDART00000140450
cx23
connexin 23
chr4_+_49322310 0.07 ENSDART00000184154
ENSDART00000167162
BX942819.1

chr17_-_43517542 0.06 ENSDART00000133665
mrpl35
mitochondrial ribosomal protein L35
chr3_-_46817838 0.05 ENSDART00000028610
elavl3
ELAV like neuron-specific RNA binding protein 3
chr1_+_33322555 0.04 ENSDART00000113486
mxra5a
matrix-remodelling associated 5a
chr9_+_18572970 0.03 ENSDART00000114860
lacc1
laccase (multicopper oxidoreductase) domain containing 1
chr20_+_46897504 0.02 ENSDART00000158124
si:ch73-21k16.1
si:ch73-21k16.1
chr15_-_31401361 0.02 ENSDART00000124360
or111-7
odorant receptor, family D, subfamily 111, member 7
chr24_-_18477672 0.02 ENSDART00000126928
ENSDART00000158393
si:dkey-73n8.3
si:dkey-73n8.3
chr25_-_27842654 0.01 ENSDART00000154852
ENSDART00000156906
asb15a
ankyrin repeat and SOCS box containing 15a
chr7_+_17106160 0.00 ENSDART00000190048
ENSDART00000180004
ENSDART00000013409
prmt3
protein arginine methyltransferase 3
chr6_+_39923052 0.00 ENSDART00000149019
itpr1a
inositol 1,4,5-trisphosphate receptor, type 1a

Network of associatons between targets according to the STRING database.

First level regulatory network of stat5a+stat5b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0008592 regulation of Toll signaling pathway(GO:0008592)
0.2 0.7 GO:0050968 chemosensory behavior(GO:0007635) detection of chemical stimulus involved in sensory perception of pain(GO:0050968)
0.2 0.6 GO:0039529 RIG-I signaling pathway(GO:0039529) regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway(GO:0039531) regulation of RIG-I signaling pathway(GO:0039535)
0.2 0.5 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.2 0.9 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.2 0.5 GO:0036076 ligamentous ossification(GO:0036076)
0.1 0.7 GO:0003261 cardiac muscle progenitor cell migration to the midline involved in heart field formation(GO:0003261)
0.1 0.5 GO:1902260 negative regulation of potassium ion transmembrane transporter activity(GO:1901017) negative regulation of potassium ion transmembrane transport(GO:1901380) negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.1 0.8 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.1 2.1 GO:0015671 oxygen transport(GO:0015671)
0.1 0.2 GO:0090247 hindbrain structural organization(GO:0021577) dorsal fin morphogenesis(GO:0035142) cell motility involved in somitogenic axis elongation(GO:0090247) cell migration involved in somitogenic axis elongation(GO:0090248)
0.1 0.2 GO:1990575 mitochondrial ornithine transport(GO:0000066) mitochondrial L-ornithine transmembrane transport(GO:1990575)
0.1 0.3 GO:0036498 IRE1-mediated unfolded protein response(GO:0036498)
0.1 1.0 GO:0051382 kinetochore assembly(GO:0051382)
0.1 21.5 GO:0046777 protein autophosphorylation(GO:0046777)
0.1 2.8 GO:0007019 microtubule depolymerization(GO:0007019)
0.0 0.7 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.5 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.0 0.5 GO:0043651 lipoxygenase pathway(GO:0019372) linoleic acid metabolic process(GO:0043651) hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.0 0.4 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0 0.9 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.1 GO:0070227 lymphocyte apoptotic process(GO:0070227)
0.0 0.4 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.5 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.0 0.2 GO:2000650 negative regulation of sodium ion transmembrane transporter activity(GO:2000650)
0.0 0.3 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.0 1.1 GO:0042737 drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
0.0 0.6 GO:0061512 protein localization to cilium(GO:0061512)
0.0 1.2 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.0 0.3 GO:0006595 polyamine metabolic process(GO:0006595)
0.0 0.4 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.0 0.5 GO:0014065 phosphatidylinositol 3-kinase signaling(GO:0014065)
0.0 0.8 GO:0006956 complement activation(GO:0006956)
0.0 0.2 GO:0001556 oocyte maturation(GO:0001556)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0097541 axonemal basal plate(GO:0097541)
0.2 2.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 0.3 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.1 1.0 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.1 0.5 GO:0030991 intraciliary transport particle A(GO:0030991)
0.1 0.4 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 0.7 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.5 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.5 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
0.0 0.2 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.3 GO:0036038 MKS complex(GO:0036038)
0.0 0.1 GO:0071203 WASH complex(GO:0071203)
0.0 0.2 GO:0014704 intercalated disc(GO:0014704)
0.0 0.1 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.9 GO:0005814 centriole(GO:0005814)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.1 GO:0031720 haptoglobin binding(GO:0031720)
0.1 0.4 GO:0004427 inorganic diphosphatase activity(GO:0004427) protein histidine phosphatase activity(GO:0101006)
0.1 0.8 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 1.2 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.1 0.3 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.1 0.4 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.1 0.7 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.1 0.8 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 0.4 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.6 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.2 GO:0034648 histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.0 0.2 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 0.1 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031)
0.0 0.5 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.0 0.5 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.7 GO:0015278 calcium-release channel activity(GO:0015278)
0.0 22.2 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 0.2 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.0 1.1 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 1.1 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.0 0.4 GO:0005112 Notch binding(GO:0005112)
0.0 0.7 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 0.1 GO:0052812 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812)
0.0 0.5 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.7 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.1 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.6 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.3 PID NCADHERIN PATHWAY N-cadherin signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1 0.4 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 0.6 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 0.1 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.3 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane