Project
PRJNA438478: RNAseq of wild type zebrafish germline
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Results for tal1
Z-value: 1.74
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Transcription factors associated with tal1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| tal1 | dr11_v1_chr22_+_16535575_16535575 | 0.83 | 1.7e-05 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_+_42467867 Show fit | 6.61 |
ENSDART00000172028
|
Pim proto-oncogene, serine/threonine kinase, related 58 |
|
| chr23_-_45319592 Show fit | 6.07 |
ENSDART00000189861
|
coiled-coil domain containing 171 |
|
| chr5_+_338154 Show fit | 4.84 |
ENSDART00000191743
|
ring finger protein 170 |
|
| chr15_-_551177 Show fit | 4.82 |
ENSDART00000066774
ENSDART00000154617 |
transgelin |
|
| chr17_-_39786222 Show fit | 4.65 |
ENSDART00000154515
|
Pim proto-oncogene, serine/threonine kinase, related 62 |
|
| chr17_-_24838927 Show fit | 4.63 |
ENSDART00000123259
|
|
|
| chr3_-_61592417 Show fit | 4.54 |
ENSDART00000155082
|
neuronal pentraxin 2a |
|
| chr25_-_18470695 Show fit | 4.17 |
ENSDART00000034377
|
carboxypeptidase A5 |
|
| chr7_-_6470431 Show fit | 4.02 |
ENSDART00000081359
|
zgc:110425 |
|
| chr12_-_656540 Show fit | 3.93 |
ENSDART00000172651
|
sulfotransferase family 2, cytosolic sulfotransferase 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of tal1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 30.0 | GO:0046777 | protein autophosphorylation(GO:0046777) |
| 0.3 | 6.2 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 0.2 | 5.0 | GO:0010508 | positive regulation of autophagy(GO:0010508) |
| 0.1 | 5.0 | GO:0051966 | regulation of synaptic transmission, glutamatergic(GO:0051966) |
| 0.2 | 4.5 | GO:0000712 | resolution of meiotic recombination intermediates(GO:0000712) |
| 0.2 | 4.4 | GO:0060287 | epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287) |
| 0.1 | 4.0 | GO:0055003 | cardiac myofibril assembly(GO:0055003) |
| 0.1 | 3.9 | GO:0051923 | sulfation(GO:0051923) |
| 0.6 | 3.5 | GO:0017182 | peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183) |
| 0.2 | 3.3 | GO:0097034 | mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.9 | GO:0000786 | nucleosome(GO:0000786) |
| 0.0 | 5.5 | GO:0005924 | cell-substrate adherens junction(GO:0005924) focal adhesion(GO:0005925) |
| 0.1 | 5.0 | GO:0031201 | SNARE complex(GO:0031201) |
| 0.1 | 4.4 | GO:0030286 | dynein complex(GO:0030286) |
| 0.1 | 4.0 | GO:0031305 | integral component of mitochondrial inner membrane(GO:0031305) |
| 0.1 | 3.6 | GO:0043186 | P granule(GO:0043186) |
| 0.1 | 3.3 | GO:0016605 | PML body(GO:0016605) |
| 0.1 | 3.2 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.1 | 3.2 | GO:0005901 | caveola(GO:0005901) plasma membrane raft(GO:0044853) |
| 0.6 | 2.6 | GO:0097255 | R2TP complex(GO:0097255) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 17.8 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
| 0.4 | 8.4 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.2 | 5.2 | GO:0016881 | acid-amino acid ligase activity(GO:0016881) |
| 1.1 | 4.5 | GO:0008310 | single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310) |
| 0.0 | 4.5 | GO:0020037 | heme binding(GO:0020037) |
| 0.1 | 4.4 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
| 0.1 | 3.9 | GO:0008146 | sulfotransferase activity(GO:0008146) |
| 0.1 | 3.7 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.0 | 3.6 | GO:0003724 | RNA helicase activity(GO:0003724) |
| 0.1 | 3.5 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 3.2 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.1 | 2.4 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.0 | 1.9 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.0 | 1.6 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.0 | 1.1 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 1.0 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 0.9 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.0 | 0.5 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.0 | 0.5 | PID ARF 3PATHWAY | Arf1 pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.2 | REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | Genes involved in 3' -UTR-mediated translational regulation |
| 0.1 | 4.1 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.0 | 2.2 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 2.0 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 1.9 | REACTOME SIGNALING BY ERBB4 | Genes involved in Signaling by ERBB4 |
| 0.0 | 1.7 | REACTOME TRNA AMINOACYLATION | Genes involved in tRNA Aminoacylation |
| 0.0 | 1.4 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.1 | 1.3 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 1.0 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.1 | 1.0 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |