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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for tbx5a+tbx5b
Z-value: 1.28
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Transcription factors associated with tbx5a+tbx5b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| tbx5a | dr11_v1_chr5_-_72289648_72289648 | 0.76 | 2.7e-04 | Click! |
| tbx5b | dr11_v1_chr5_+_23152282_23152282 | -0.34 | 1.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr24_-_10021341 Show fit | 4.69 |
ENSDART00000137250
|
zgc:173856 |
|
| chr24_-_10006158 Show fit | 4.61 |
ENSDART00000106244
|
zgc:171750 |
|
| chr3_+_43086548 Show fit | 4.53 |
ENSDART00000163579
|
si:dkey-43p13.5 |
|
| chr24_-_9997948 Show fit | 4.51 |
ENSDART00000136274
|
si:ch211-146l10.7 |
|
| chr24_+_10027902 Show fit | 4.23 |
ENSDART00000175961
ENSDART00000172773 |
si:ch211-146l10.8 |
|
| chr11_+_29537756 Show fit | 4.18 |
ENSDART00000103388
|
wu:fi42e03 |
|
| chr20_-_43743700 Show fit | 4.03 |
ENSDART00000100620
|
si:dkeyp-50f7.2 |
|
| chr10_+_19596214 Show fit | 3.74 |
ENSDART00000183110
|
|
|
| chr19_-_34999379 Show fit | 3.57 |
ENSDART00000051751
|
zgc:113424 |
|
| chr10_+_19569052 Show fit | 3.56 |
ENSDART00000058425
|
|
Network of associatons between targets according to the STRING database.
First level regulatory network of tbx5a+tbx5b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.3 | GO:0048484 | enteric nervous system development(GO:0048484) |
| 0.1 | 2.2 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 0.1 | 2.1 | GO:0015693 | magnesium ion transport(GO:0015693) |
| 0.0 | 2.0 | GO:0051604 | protein maturation(GO:0051604) |
| 0.0 | 1.7 | GO:0006821 | chloride transport(GO:0006821) |
| 0.0 | 1.3 | GO:0006637 | acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383) |
| 0.1 | 1.2 | GO:1905207 | regulation of cardiocyte differentiation(GO:1905207) regulation of cardiac muscle cell differentiation(GO:2000725) |
| 0.1 | 1.2 | GO:0048312 | intracellular distribution of mitochondria(GO:0048312) |
| 0.1 | 1.2 | GO:0043951 | negative regulation of cAMP-mediated signaling(GO:0043951) |
| 0.1 | 1.2 | GO:0019433 | triglyceride catabolic process(GO:0019433) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.9 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.0 | 2.5 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 2.2 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.0 | 2.1 | GO:0005923 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
| 0.0 | 1.7 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.1 | 1.6 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.3 | 1.1 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
| 0.2 | 1.1 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.1 | 1.1 | GO:0032039 | integrator complex(GO:0032039) |
| 0.0 | 1.1 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.8 | GO:0004180 | carboxypeptidase activity(GO:0004180) |
| 0.1 | 2.2 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.1 | 2.1 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.1 | 2.1 | GO:0051393 | muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393) |
| 0.2 | 1.7 | GO:0072320 | volume-sensitive chloride channel activity(GO:0072320) |
| 0.0 | 1.5 | GO:0008175 | tRNA methyltransferase activity(GO:0008175) |
| 0.0 | 1.5 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.3 | 1.3 | GO:0051139 | calcium:proton antiporter activity(GO:0015369) metal ion:proton antiporter activity(GO:0051139) |
| 0.1 | 1.3 | GO:0015924 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) mannosyl-oligosaccharide mannosidase activity(GO:0015924) |
| 0.1 | 1.3 | GO:0050291 | sphingosine N-acyltransferase activity(GO:0050291) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.9 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 1.2 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 1.0 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.0 | 0.9 | PID TRAIL PATHWAY | TRAIL signaling pathway |
| 0.0 | 0.9 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.0 | 0.8 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.0 | 0.8 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.0 | 0.8 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.1 | 0.6 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 0.6 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.8 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.0 | 1.6 | REACTOME RNA POL II PRE TRANSCRIPTION EVENTS | Genes involved in RNA Polymerase II Pre-transcription Events |
| 0.1 | 1.5 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.2 | 1.2 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.1 | 1.0 | REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY | Genes involved in Adenylate cyclase activating pathway |
| 0.1 | 0.9 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.0 | 0.9 | REACTOME FGFR LIGAND BINDING AND ACTIVATION | Genes involved in FGFR ligand binding and activation |
| 0.0 | 0.8 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.0 | 0.7 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.0 | 0.7 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |