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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for tcf7l1a+tcf7l1b+tcf7l2

Z-value: 0.64

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Transcription factors associated with tcf7l1a+tcf7l1b+tcf7l2

Gene Symbol Gene ID Gene Info
tcf7l2
ENSDARG00000004415 transcription factor 7 like 2
tcf7l1b
ENSDARG00000007369 transcription factor 7 like 1b
tcf7l1a
ENSDARG00000038159 transcription factor 7 like 1a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tcf7l1bdr11_v1_chr8_-_52143109_52143109-0.999.7e-15Click!
tcf7l2dr11_v1_chr12_-_31103187_31103316-0.967.3e-10Click!
tcf7l1adr11_v1_chr10_-_42237304_42237304-0.097.4e-01Click!

Activity profile of tcf7l1a+tcf7l1b+tcf7l2 motif

Sorted Z-values of tcf7l1a+tcf7l1b+tcf7l2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_53143667 4.28 ENSDART00000079694
gnai2b
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b
chr17_-_4245311 2.52 ENSDART00000055379
gdf3
growth differentiation factor 3
chr17_-_4245902 2.14 ENSDART00000151851
gdf3
growth differentiation factor 3
chr3_-_55650771 2.11 ENSDART00000162413
axin2
axin 2 (conductin, axil)
chr4_-_77114795 1.72 ENSDART00000144849
CU467646.2

chr4_+_9836465 1.64 ENSDART00000004879
hsp90b1
heat shock protein 90, beta (grp94), member 1
chr6_-_53144336 1.63 ENSDART00000154429
gnai2b
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b
chr23_-_24226533 1.55 ENSDART00000109134
plekhm2
pleckstrin homology domain containing, family M (with RUN domain) member 2
chr5_+_15992655 1.55 ENSDART00000182148
znrf3
zinc and ring finger 3
chr10_+_19569052 1.55 ENSDART00000058425
CABZ01059627.1

chr3_-_55650417 1.45 ENSDART00000171441
axin2
axin 2 (conductin, axil)
chr10_-_21542702 1.40 ENSDART00000146761
ENSDART00000134502
zgc:165539
zgc:165539
chr23_-_18057270 1.38 ENSDART00000173385
zgc:92287
zgc:92287
chr16_+_39159752 1.34 ENSDART00000122081
sybu
syntabulin (syntaxin-interacting)
chr14_+_34492288 1.30 ENSDART00000144301
wnt8a
wingless-type MMTV integration site family, member 8a
chr1_+_49814461 1.28 ENSDART00000132405
lef1
lymphoid enhancer-binding factor 1
chr22_-_21150845 1.27 ENSDART00000027345
tmem59l
transmembrane protein 59-like
chr12_+_35203091 1.26 ENSDART00000153022
ndst2b
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2b
chr2_+_41526904 1.23 ENSDART00000127520
acvr1l
activin A receptor, type 1 like
chr9_-_27410597 1.13 ENSDART00000135652
ENSDART00000042297
kdelc1
KDEL (Lys-Asp-Glu-Leu) containing 1
chr14_+_34495216 1.06 ENSDART00000147756
wnt8a
wingless-type MMTV integration site family, member 8a
chr6_-_14038804 0.98 ENSDART00000184606
ENSDART00000184609
etv5b
ets variant 5b
chr2_-_30784502 0.98 ENSDART00000056735
rgs20
regulator of G protein signaling 20
chr15_-_35930070 0.97 ENSDART00000076229
irs1
insulin receptor substrate 1
chr18_-_39636348 0.97 ENSDART00000129828
cyp19a1a
cytochrome P450, family 19, subfamily A, polypeptide 1a
chr13_+_33268657 0.94 ENSDART00000002095
tmem39b
transmembrane protein 39B
chr23_+_37579107 0.89 ENSDART00000169376
plekhg5b
pleckstrin homology domain containing, family G (with RhoGef domain) member 5b
chr16_+_39146696 0.88 ENSDART00000121756
ENSDART00000084381
sybu
syntabulin (syntaxin-interacting)
chr22_+_21549419 0.83 ENSDART00000139411
plpp2b
phospholipid phosphatase 2b
chr25_-_16552135 0.82 ENSDART00000125836
si:ch211-266k8.4
si:ch211-266k8.4
chr20_-_38787047 0.81 ENSDART00000152913
ENSDART00000153430
dnajc5ga
DnaJ (Hsp40) homolog, subfamily C, member 5 gamma a
chr7_-_24112484 0.80 ENSDART00000111923
ajuba
ajuba LIM protein
chr11_+_19068442 0.79 ENSDART00000171766
magi1b
membrane associated guanylate kinase, WW and PDZ domain containing 1b
chr15_-_8309207 0.77 ENSDART00000143880
ENSDART00000061351
tnfrsf19
tumor necrosis factor receptor superfamily, member 19
chr17_+_44030692 0.77 ENSDART00000049503
peli2
pellino E3 ubiquitin protein ligase family member 2
chr5_-_28149767 0.75 ENSDART00000051515
zgc:110329
zgc:110329
chr14_+_30413312 0.75 ENSDART00000186864
cnot7
CCR4-NOT transcription complex, subunit 7
chr1_+_49814942 0.75 ENSDART00000164936
lef1
lymphoid enhancer-binding factor 1
chr20_-_38787341 0.75 ENSDART00000136771
dnajc5ga
DnaJ (Hsp40) homolog, subfamily C, member 5 gamma a
chr12_+_48340133 0.74 ENSDART00000152899
ENSDART00000153335
ENSDART00000054788
ddit4
DNA-damage-inducible transcript 4
chr20_+_28266892 0.73 ENSDART00000103330
chac1
ChaC, cation transport regulator homolog 1 (E. coli)
chr8_+_20415824 0.72 ENSDART00000009081
ENSDART00000145444
mob3a
MOB kinase activator 3A
chr3_-_15470944 0.69 ENSDART00000185302
spns1
spinster homolog 1 (Drosophila)
chr5_+_60590796 0.68 ENSDART00000159859
tmem132e
transmembrane protein 132E
chr8_-_18899427 0.67 ENSDART00000079840
rorca
RAR-related orphan receptor C a
chr15_+_40188076 0.67 ENSDART00000063779
efhd1
EF-hand domain family, member D1
chr23_+_26017227 0.67 ENSDART00000002939
pfkfb1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr6_-_30485009 0.66 ENSDART00000025698
zgc:153311
zgc:153311
chr6_+_12527725 0.66 ENSDART00000149328
stk24b
serine/threonine kinase 24b (STE20 homolog, yeast)
chr11_+_14321113 0.66 ENSDART00000039822
ENSDART00000137347
ENSDART00000132997
ptbp1b
polypyrimidine tract binding protein 1b
chr9_-_28990649 0.64 ENSDART00000078823
ptpn4a
protein tyrosine phosphatase, non-receptor type 4a
chr20_-_31496679 0.62 ENSDART00000153437
ENSDART00000153193
sash1a
SAM and SH3 domain containing 1a
chr12_+_46855036 0.61 ENSDART00000148670
adkb
adenosine kinase b
chr12_+_10115964 0.60 ENSDART00000152369
si:dkeyp-118b1.2
si:dkeyp-118b1.2
chr24_+_32411753 0.59 ENSDART00000058530
neurod6a
neuronal differentiation 6a
chr16_-_25233515 0.59 ENSDART00000058943
zgc:110182
zgc:110182
chr17_-_8638713 0.58 ENSDART00000148971
ctbp2a
C-terminal binding protein 2a
chr24_-_1985007 0.58 ENSDART00000189870
PARD3 (1 of many)
par-3 family cell polarity regulator
chr7_+_36470159 0.57 ENSDART00000188703
aktip
akt interacting protein
chr17_-_26507289 0.57 ENSDART00000155616
ccser2a
coiled-coil serine-rich protein 2a
chr23_-_22113455 0.56 ENSDART00000142474
phc2a
polyhomeotic homolog 2a (Drosophila)
chr20_+_23498255 0.56 ENSDART00000149922
palld
palladin, cytoskeletal associated protein
chr5_-_7513082 0.55 ENSDART00000158913
bmpr1ba
bone morphogenetic protein receptor, type IBa
chr1_+_47499888 0.54 ENSDART00000027624
stn1
STN1, CST complex subunit
chr23_+_2714949 0.54 ENSDART00000105284
ncoa6
nuclear receptor coactivator 6
chr13_-_31008275 0.53 ENSDART00000139394
wdfy4
WDFY family member 4
chr25_+_22571475 0.53 ENSDART00000161559
stra6
stimulated by retinoic acid 6
chr10_+_8847033 0.53 ENSDART00000140894
itga2.1
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor), tandem duplicate 1
chr9_+_46745348 0.51 ENSDART00000025256
igfbp2b
insulin-like growth factor binding protein 2b
chr25_+_418932 0.48 ENSDART00000059193
prtgb
protogenin homolog b (Gallus gallus)
chr3_+_15773991 0.48 ENSDART00000089923
znf652
zinc finger protein 652
chr2_+_9822319 0.47 ENSDART00000144078
ENSDART00000144371
anxa13l
annexin A13, like
chr7_+_29890292 0.46 ENSDART00000170403
ENSDART00000168600
tln2a
talin 2a
chr4_-_13255700 0.45 ENSDART00000162277
ENSDART00000026593
grip1
glutamate receptor interacting protein 1
chr24_+_21174851 0.45 ENSDART00000154940
ENSDART00000155977
ENSDART00000122762
naa50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr20_+_27093042 0.45 ENSDART00000024595
ubr7
ubiquitin protein ligase E3 component n-recognin 7
chr15_-_10341048 0.44 ENSDART00000171013
tenm4
teneurin transmembrane protein 4
chr14_+_22172047 0.44 ENSDART00000114750
ENSDART00000148259
gabrb2
gamma-aminobutyric acid (GABA) A receptor, beta 2
chr24_-_5932982 0.42 ENSDART00000138412
ENSDART00000135124
ENSDART00000007373
acbd5a
acyl-CoA binding domain containing 5a
chr22_-_3182965 0.41 ENSDART00000158009
lonp1
lon peptidase 1, mitochondrial
chr7_-_32895668 0.41 ENSDART00000141828
ano5b
anoctamin 5b
chr2_+_5843694 0.40 ENSDART00000182364
dis3l2
DIS3 like 3'-5' exoribonuclease 2
chr2_-_30784198 0.39 ENSDART00000182523
ENSDART00000147355
rgs20
regulator of G protein signaling 20
chr25_+_16312258 0.39 ENSDART00000064187
parvaa
parvin, alpha a
chr4_-_16658514 0.38 ENSDART00000133837
dennd5b
DENN/MADD domain containing 5B
chr21_+_5531138 0.37 ENSDART00000163825
ly6m6
lymphocyte antigen 6 family member M6
chr15_-_16384184 0.37 ENSDART00000154504
fam222bb
family with sequence similarity 222, member Bb
chr21_-_25522906 0.35 ENSDART00000110923
cnksr2b
connector enhancer of kinase suppressor of Ras 2b
chr5_+_26728115 0.35 ENSDART00000098545
tmem150aa
transmembrane protein 150Aa
chr14_+_30413758 0.35 ENSDART00000092953
cnot7
CCR4-NOT transcription complex, subunit 7
chr6_+_6662479 0.34 ENSDART00000065568
zgc:113227
zgc:113227
chr7_-_9674073 0.34 ENSDART00000187902
lrrk1
leucine-rich repeat kinase 1
chr24_+_21174523 0.34 ENSDART00000183849
naa50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr5_+_37744625 0.34 ENSDART00000014031
dpf2
D4, zinc and double PHD fingers family 2
chr25_-_17587785 0.34 ENSDART00000073679
ENSDART00000146851
zgc:66449
zgc:66449
chr3_-_56569968 0.33 ENSDART00000165317
SMIM10
Danio rerio uncharacterized LOC797202 (LOC797202), mRNA.
chr17_-_50010121 0.32 ENSDART00000122747
tmem30aa
transmembrane protein 30Aa
chr17_-_17759138 0.31 ENSDART00000157128
ENSDART00000123845
adck1
aarF domain containing kinase 1
chr7_-_42206720 0.31 ENSDART00000110907
itfg1
integrin alpha FG-GAP repeat containing 1
chr23_+_16620801 0.30 ENSDART00000189859
ENSDART00000184578
snphb
syntaphilin b
chr21_-_31241254 0.30 ENSDART00000065365
tpst1l
tyrosylprotein sulfotransferase 1, like
chr7_-_72423666 0.30 ENSDART00000191214
rph3ab
rabphilin 3A homolog (mouse), b
chr1_-_19233890 0.30 ENSDART00000127145
ptprdb
protein tyrosine phosphatase, receptor type, D, b
chr8_+_18555559 0.30 ENSDART00000149523
tab3
TGF-beta activated kinase 1/MAP3K7 binding protein 3
chr19_-_6982272 0.30 ENSDART00000141913
ENSDART00000150957
znf384l
zinc finger protein 384 like
chr13_-_31389661 0.29 ENSDART00000134630
zdhhc16a
zinc finger, DHHC-type containing 16a
chr19_-_32940040 0.29 ENSDART00000179947
azin1b
antizyme inhibitor 1b
chr20_-_9436521 0.29 ENSDART00000133000
zgc:101840
zgc:101840
chr15_+_30158652 0.28 ENSDART00000190682
nlk2
nemo-like kinase, type 2
chr22_-_34979139 0.28 ENSDART00000116455
ENSDART00000133537
arhgap19
Rho GTPase activating protein 19
chr8_+_17009199 0.28 ENSDART00000139452
pde4d
phosphodiesterase 4D, cAMP-specific
chr1_-_681116 0.27 ENSDART00000165894
adamts1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr7_+_42206847 0.26 ENSDART00000149250
phkb
phosphorylase kinase, beta
chr17_-_20897407 0.26 ENSDART00000149481
ank3b
ankyrin 3b
chr23_-_39784368 0.26 ENSDART00000110282
si:ch211-286f9.2
si:ch211-286f9.2
chr17_-_21049260 0.25 ENSDART00000155300
ENSDART00000185758
bicc1a
BicC family RNA binding protein 1a
chr8_-_11004726 0.25 ENSDART00000192594
ENSDART00000020116
trim33
tripartite motif containing 33
chr7_-_18554603 0.25 ENSDART00000108938
msantd1
Myb/SANT-like DNA-binding domain containing 1
chr11_-_40647190 0.24 ENSDART00000173217
ENSDART00000173276
ENSDART00000147264
fam213b
family with sequence similarity 213, member B
chr19_+_9212031 0.24 ENSDART00000052930
ndufv1
NADH dehydrogenase (ubiquinone) flavoprotein 1
chr5_+_44190974 0.24 ENSDART00000182634
ENSDART00000190626
TMEM8B
si:dkey-84j12.1
chr6_-_11362871 0.24 ENSDART00000151125
pcnt
pericentrin
chr5_-_22082918 0.23 ENSDART00000020908
zc4h2
zinc finger, C4H2 domain containing
chr5_-_18474486 0.23 ENSDART00000090580
si:dkey-215k6.1
si:dkey-215k6.1
chr3_-_26978793 0.23 ENSDART00000155396
nubp1
nucleotide binding protein 1 (MinD homolog, E. coli)
chr21_-_25522510 0.23 ENSDART00000162711
cnksr2b
connector enhancer of kinase suppressor of Ras 2b
chr13_-_34858500 0.22 ENSDART00000184843
sptlc3
serine palmitoyltransferase, long chain base subunit 3
chr7_+_30051880 0.22 ENSDART00000075609
pstpip1b
proline-serine-threonine phosphatase interacting protein 1b
chr22_+_31207799 0.21 ENSDART00000133267
grip2b
glutamate receptor interacting protein 2b
chr3_-_29968015 0.20 ENSDART00000077119
ENSDART00000139310
bcat2
branched chain amino-acid transaminase 2, mitochondrial
chr21_+_45267589 0.20 ENSDART00000182963
ENSDART00000155681
ENSDART00000192632
tcf7
transcription factor 7
chr7_+_37377335 0.20 ENSDART00000111842
sall1a
spalt-like transcription factor 1a
chr17_-_24714837 0.20 ENSDART00000154871
si:ch211-15d5.11
si:ch211-15d5.11
chr8_-_22739757 0.20 ENSDART00000182167
ENSDART00000171891
iqsec2a
IQ motif and Sec7 domain 2a
chr7_-_71486162 0.20 ENSDART00000045253
aco1
aconitase 1, soluble
chr15_-_43768776 0.20 ENSDART00000170398
grm5b
glutamate receptor, metabotropic 5b
chr7_+_38750871 0.19 ENSDART00000114238
ENSDART00000052325
ENSDART00000137001
f2
coagulation factor II (thrombin)
chr8_-_24791060 0.18 ENSDART00000111617
rbm15
RNA binding motif protein 15
chr17_-_20897250 0.18 ENSDART00000088106
ank3b
ankyrin 3b
chr18_+_20226843 0.18 ENSDART00000100632
tle3a
transducin-like enhancer of split 3a
chr13_-_24906307 0.18 ENSDART00000148191
ENSDART00000189810
kat6b
K(lysine) acetyltransferase 6B
chr9_-_9998087 0.18 ENSDART00000124423
ugt1ab
UDP glucuronosyltransferase 1 family a, b
chr7_-_54677143 0.18 ENSDART00000163748
ccnd1
cyclin D1
chr24_-_32408404 0.17 ENSDART00000144157
si:ch211-56a11.2
si:ch211-56a11.2
chr12_+_32323098 0.16 ENSDART00000188722
ANKFN1
si:ch211-277e21.2
chr13_+_15656042 0.16 ENSDART00000134240
mark3a
MAP/microtubule affinity-regulating kinase 3a
chr13_-_18835254 0.16 ENSDART00000147579
ENSDART00000146795
lzts2a
leucine zipper, putative tumor suppressor 2a
chr25_-_22187397 0.16 ENSDART00000123211
ENSDART00000139110
pkp3a
plakophilin 3a
chr23_-_32092443 0.15 ENSDART00000133688
letmd1
LETM1 domain containing 1
chr8_+_35356944 0.15 ENSDART00000143243
si:dkeyp-14d3.1
si:dkeyp-14d3.1
chr19_-_10207103 0.15 ENSDART00000151629
znf865
zinc finger protein 865
chr12_+_27536270 0.15 ENSDART00000133719
etv4
ets variant 4
chr18_-_44888375 0.15 ENSDART00000160506
si:ch211-71n6.4
si:ch211-71n6.4
chr3_+_55288200 0.15 ENSDART00000157002
ENSDART00000155600
si:dkey-114l24.2
si:dkey-114l24.2
chr14_-_47963115 0.15 ENSDART00000003826
rapgef2
Rap guanine nucleotide exchange factor (GEF) 2
chr22_-_22242884 0.14 ENSDART00000020937
hdgfl2
HDGF like 2
chr9_-_12034444 0.14 ENSDART00000038651
znf804a
zinc finger protein 804A
chr21_+_45268112 0.14 ENSDART00000157136
tcf7
transcription factor 7
chr11_+_34522554 0.14 ENSDART00000109833
zmat3
zinc finger, matrin-type 3
chr21_+_45316330 0.14 ENSDART00000056474
ENSDART00000149314
ENSDART00000149272
ENSDART00000149156
ENSDART00000099497
tcf7
transcription factor 7
chr9_-_28399071 0.14 ENSDART00000104317
ENSDART00000064343
klf7b
Kruppel-like factor 7b
chr22_+_35930526 0.14 ENSDART00000169242
LO016987.1

chr24_+_11334733 0.14 ENSDART00000147552
ENSDART00000143171
si:dkey-12l12.1
si:dkey-12l12.1
chr5_-_65000312 0.13 ENSDART00000192893
ANXA1 (1 of many)
zgc:110283
chr16_-_18702249 0.13 ENSDART00000191595
fhod3b
formin homology 2 domain containing 3b
chr14_+_21159693 0.13 ENSDART00000192678
zgc:136929
zgc:136929
chr11_+_22134540 0.13 ENSDART00000190502
MDFI
si:dkey-91m3.1
chr9_-_9992697 0.12 ENSDART00000123415
ugt1ab
UDP glucuronosyltransferase 1 family a, b
chr9_+_3087889 0.12 ENSDART00000146148
ppp1r9ala
protein phosphatase 1 regulatory subunit 9A-like A
chr13_-_23264724 0.12 ENSDART00000051886
si:dkey-103j14.5
si:dkey-103j14.5
chr11_+_40043569 0.11 ENSDART00000130278
si:dkey-264d12.1
si:dkey-264d12.1
chr7_+_16991711 0.11 ENSDART00000173660
nav2a
neuron navigator 2a
chr7_+_27977065 0.11 ENSDART00000089574
tub
tubby bipartite transcription factor
chr9_+_27354414 0.10 ENSDART00000163804
tlr20.2
toll-like receptor 20, tandem duplicate 2
chr11_+_34523132 0.10 ENSDART00000192257
zmat3
zinc finger, matrin-type 3
chr21_-_41147818 0.10 ENSDART00000167339
ENSDART00000192730
msx2b
muscle segment homeobox 2b
chr9_+_17306162 0.10 ENSDART00000075926
scel
sciellin
chr4_-_14191717 0.10 ENSDART00000147928
pus7l
pseudouridylate synthase 7-like
chr7_+_27976448 0.10 ENSDART00000181026
tub
tubby bipartite transcription factor
chr8_+_8671229 0.10 ENSDART00000131963
usp11
ubiquitin specific peptidase 11
chr3_-_31057624 0.10 ENSDART00000152901
armc5
armadillo repeat containing 5
chr19_-_32487469 0.09 ENSDART00000050130
gmpr
guanosine monophosphate reductase
chr8_-_34051548 0.09 ENSDART00000105204
pbx3b
pre-B-cell leukemia homeobox 3b
chr3_-_33573252 0.09 ENSDART00000191339
ENSDART00000184612
ENSDART00000187232
ENSDART00000190671
CR847537.1

chr22_-_294700 0.09 ENSDART00000189179
CABZ01079179.1

chr25_-_35591022 0.09 ENSDART00000188317
ENSDART00000187609
clpxb
caseinolytic mitochondrial matrix peptidase chaperone subunit b
chr21_-_20328375 0.09 ENSDART00000079593
slc26a1
solute carrier family 26 (anion exchanger), member 1
chr15_+_41932853 0.08 ENSDART00000183581
ENSDART00000157807
si:ch211-191a16.2
si:ch211-191a16.2
chr17_+_27176243 0.08 ENSDART00000162527
si:ch211-160f23.7
si:ch211-160f23.7
chr9_+_32431666 0.08 ENSDART00000187614
plcl1
phospholipase C like 1
chr8_-_38105053 0.08 ENSDART00000131546
adgra2
adhesion G protein-coupled receptor A2
chr22_-_263117 0.08 ENSDART00000158134
zgc:66156
zgc:66156
chr4_-_13538714 0.08 ENSDART00000067154
il26
interleukin 26
chr4_-_14191434 0.08 ENSDART00000142374
ENSDART00000136730
pus7l
pseudouridylate synthase 7-like
chr16_-_33806390 0.07 ENSDART00000160671
rspo1
R-spondin 1
chr10_-_39011514 0.07 ENSDART00000075123
pcp4a
Purkinje cell protein 4a
chr1_+_35862550 0.07 ENSDART00000132118
si:ch211-194g2.4
si:ch211-194g2.4
chr2_-_59376735 0.07 ENSDART00000193624
ftr38
finTRIM family, member 38
chr20_+_36234335 0.07 ENSDART00000193484
ENSDART00000181664
cnih3
cornichon family AMPA receptor auxiliary protein 3
chr6_-_6976096 0.07 ENSDART00000151822
ENSDART00000039443
ENSDART00000177960
tuba8l4
tubulin, alpha 8 like 4

Network of associatons between targets according to the STRING database.

First level regulatory network of tcf7l1a+tcf7l1b+tcf7l2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 4.7 GO:1900145 nodal signaling pathway involved in determination of left/right asymmetry(GO:0038107) regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145)
0.8 2.4 GO:0072111 spinal cord anterior/posterior patterning(GO:0021512) cell proliferation involved in pronephros development(GO:0039015) cell proliferation involved in kidney development(GO:0072111)
0.7 2.0 GO:0060784 regulation of cell proliferation involved in tissue homeostasis(GO:0060784)
0.6 2.2 GO:0060074 synapse maturation(GO:0060074)
0.5 5.9 GO:0035588 adenosine receptor signaling pathway(GO:0001973) purinergic receptor signaling pathway(GO:0035587) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.4 1.5 GO:0032801 receptor catabolic process(GO:0032801)
0.3 1.0 GO:0030237 female sex determination(GO:0030237) male sex determination(GO:0030238)
0.3 1.2 GO:0035124 embryonic caudal fin morphogenesis(GO:0035124)
0.3 3.6 GO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.3 1.6 GO:0035889 otolith tethering(GO:0035889)
0.3 0.8 GO:0060148 negative regulation of hippo signaling(GO:0035331) positive regulation of posttranscriptional gene silencing(GO:0060148) positive regulation of gene silencing by miRNA(GO:2000637)
0.2 0.8 GO:0071962 mitotic sister chromatid cohesion, centromeric(GO:0071962)
0.2 0.9 GO:0014045 establishment of endothelial blood-brain barrier(GO:0014045)
0.2 0.8 GO:0008592 regulation of Toll signaling pathway(GO:0008592)
0.1 1.6 GO:1903729 regulation of plasma membrane organization(GO:1903729)
0.1 0.5 GO:0002568 somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153)
0.1 1.3 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.1 0.5 GO:0071938 vitamin A transport(GO:0071938) vitamin A import(GO:0071939)
0.1 0.6 GO:0044209 AMP salvage(GO:0044209)
0.1 1.1 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.1 0.3 GO:0021877 forebrain neuron fate commitment(GO:0021877)
0.1 0.4 GO:0032289 central nervous system myelin formation(GO:0032289)
0.1 0.6 GO:0070073 clustering of voltage-gated calcium channels(GO:0070073)
0.1 1.0 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.1 0.4 GO:0010586 miRNA metabolic process(GO:0010586)
0.1 0.8 GO:0006751 glutathione catabolic process(GO:0006751)
0.1 0.4 GO:0030242 pexophagy(GO:0030242)
0.1 0.2 GO:0099553 trans-synaptic signaling by lipid, modulating synaptic transmission(GO:0099552) trans-synaptic signaling by endocannabinoid, modulating synaptic transmission(GO:0099553)
0.1 0.3 GO:0051659 maintenance of mitochondrion location(GO:0051659)
0.1 0.7 GO:0090398 cellular senescence(GO:0090398)
0.1 0.2 GO:0009098 leucine biosynthetic process(GO:0009098)
0.1 0.7 GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane(GO:0098887) endosome to plasma membrane protein transport(GO:0099638) neurotransmitter receptor transport, endosome to plasma membrane(GO:0099639)
0.0 0.2 GO:0010039 response to iron ion(GO:0010039)
0.0 0.3 GO:0015846 polyamine transport(GO:0015846) polyamine transmembrane transport(GO:1902047) regulation of polyamine transmembrane transport(GO:1902267) positive regulation of polyamine transmembrane transport(GO:1902269)
0.0 0.5 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0 1.0 GO:0071456 cellular response to hypoxia(GO:0071456)
0.0 0.5 GO:0035677 posterior lateral line neuromast hair cell development(GO:0035677)
0.0 0.6 GO:0098927 early endosome to late endosome transport(GO:0045022) vesicle-mediated transport between endosomal compartments(GO:0098927)
0.0 0.7 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.3 GO:0006477 protein sulfation(GO:0006477) peptidyl-tyrosine sulfation(GO:0006478)
0.0 0.2 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571)
0.0 0.2 GO:0006953 acute-phase response(GO:0006953)
0.0 0.2 GO:0048569 post-embryonic organ development(GO:0048569)
0.0 0.1 GO:0033345 asparagine catabolic process(GO:0006530) asparagine catabolic process via L-aspartate(GO:0033345)
0.0 0.4 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.0 0.5 GO:0016233 telomere capping(GO:0016233)
0.0 0.1 GO:0019532 oxalate transport(GO:0019532)
0.0 0.2 GO:0035108 limb morphogenesis(GO:0035108)
0.0 0.2 GO:0034312 diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512)
0.0 0.2 GO:0051013 microtubule severing(GO:0051013)
0.0 0.2 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.0 0.2 GO:0061056 sclerotome development(GO:0061056)
0.0 0.1 GO:0021634 optic nerve formation(GO:0021634)
0.0 0.4 GO:0048263 determination of dorsal identity(GO:0048263)
0.0 0.9 GO:0043534 blood vessel endothelial cell migration(GO:0043534)
0.0 0.3 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.1 GO:0061011 hepatic duct development(GO:0061011)
0.0 0.2 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.2 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0097189 apoptotic body(GO:0097189)
0.2 1.2 GO:0070724 BMP receptor complex(GO:0070724)
0.2 0.5 GO:1990879 CST complex(GO:1990879)
0.2 0.7 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.2 0.8 GO:0031415 NatA complex(GO:0031415)
0.1 0.6 GO:0070695 FHF complex(GO:0070695)
0.1 5.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 1.1 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 1.6 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.1 2.5 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.1 GO:1902560 GMP reductase complex(GO:1902560)
0.0 0.4 GO:0000178 exosome (RNase complex)(GO:0000178)
0.0 0.3 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 0.5 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.2 GO:0031211 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.1 GO:1990909 Wnt signalosome(GO:1990909)
0.0 0.3 GO:0071565 nBAF complex(GO:0071565)
0.0 0.8 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 2.1 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 0.9 GO:0030139 endocytic vesicle(GO:0030139)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.9 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.2 0.7 GO:0071889 14-3-3 protein binding(GO:0071889)
0.2 0.7 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.2 3.8 GO:0019894 kinesin binding(GO:0019894)
0.2 1.0 GO:0070330 aromatase activity(GO:0070330)
0.2 1.3 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.1 1.8 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 0.6 GO:0004001 adenosine kinase activity(GO:0004001)
0.1 2.0 GO:0008301 DNA binding, bending(GO:0008301)
0.1 1.0 GO:0005158 insulin receptor binding(GO:0005158)
0.1 0.8 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.1 0.5 GO:0034632 retinol transporter activity(GO:0034632)
0.1 1.1 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 0.2 GO:0003994 aconitate hydratase activity(GO:0003994)
0.1 0.5 GO:0098847 single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.1 2.4 GO:0005109 frizzled binding(GO:0005109)
0.1 0.2 GO:0052656 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.0 0.3 GO:0042978 ornithine decarboxylase activator activity(GO:0042978)
0.0 0.7 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.0 0.5 GO:0031994 insulin-like growth factor I binding(GO:0031994) insulin-like growth factor II binding(GO:0031995)
0.0 0.4 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.0 0.5 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.3 GO:0008476 protein-tyrosine sulfotransferase activity(GO:0008476)
0.0 0.8 GO:0042577 lipid phosphatase activity(GO:0042577)
0.0 0.1 GO:0003920 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.0 0.2 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.2 GO:0099530 G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.0 4.0 GO:0005125 cytokine activity(GO:0005125)
0.0 0.1 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.0 0.4 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 1.7 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.2 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.4 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.1 GO:0001607 neuromedin U receptor activity(GO:0001607)
0.0 0.1 GO:0039706 co-receptor binding(GO:0039706)
0.0 0.9 GO:0051287 NAD binding(GO:0051287)
0.0 0.2 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.3 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.6 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.1 4.7 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.1 1.0 PID S1P S1P2 PATHWAY S1P2 pathway
0.0 1.4 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 1.3 ST G ALPHA I PATHWAY G alpha i Pathway
0.0 0.2 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 4.7 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.7 PID MTOR 4PATHWAY mTOR signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 1.0 REACTOME SOS MEDIATED SIGNALLING Genes involved in SOS-mediated signalling
0.1 1.1 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.1 0.8 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 1.4 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.0 0.7 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.4 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.3 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.3 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.2 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 0.3 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.3 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.2 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.2 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism