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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for tefa+tefb

Z-value: 0.93

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Transcription factors associated with tefa+tefb

Gene Symbol Gene ID Gene Info
tefa
ENSDARG00000039117 TEF transcription factor, PAR bZIP family member a
tefb
ENSDARG00000098103 TEF transcription factor, PAR bZIP family member b
tefa
ENSDARG00000109532 TEF transcription factor, PAR bZIP family member a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tefbdr11_v1_chr3_-_5067585_50675850.993.2e-14Click!
tefadr11_v1_chr12_-_19153177_191531770.644.1e-03Click!

Activity profile of tefa+tefb motif

Sorted Z-values of tefa+tefb motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_22974019 4.74 ENSDART00000147157
ENSDART00000020434
brwd3
bromodomain and WD repeat domain containing 3
chr3_+_7763114 1.73 ENSDART00000057434
hook2
hook microtubule-tethering protein 2
chr5_-_69212184 1.67 ENSDART00000053963
mat2ab
methionine adenosyltransferase II, alpha b
chr14_+_21699129 1.61 ENSDART00000073707
stx3a
syntaxin 3A
chr7_+_38380135 1.48 ENSDART00000174005
rhpn2
rhophilin, Rho GTPase binding protein 2
chr18_-_39288894 1.44 ENSDART00000186216
mapk6
mitogen-activated protein kinase 6
chr22_+_10606863 1.38 ENSDART00000147975
rad54l2
RAD54 like 2
chr3_-_26184018 1.35 ENSDART00000191604
si:ch211-11k18.4
si:ch211-11k18.4
chr5_-_69716501 1.33 ENSDART00000158956
mob1a
MOB kinase activator 1A
chr15_+_24737599 1.31 ENSDART00000078024
crk
v-crk avian sarcoma virus CT10 oncogene homolog
chr1_+_16600690 1.28 ENSDART00000162164
mtus1b
microtubule associated tumor suppressor 1b
chr14_+_21699414 1.25 ENSDART00000169942
stx3a
syntaxin 3A
chr8_-_11324143 1.24 ENSDART00000008215
pip5k1bb
phosphatidylinositol-4-phosphate 5-kinase, type I, beta b
chr7_-_40959667 1.22 ENSDART00000084070
rbm33a
RNA binding motif protein 33a
chr20_+_38201644 1.15 ENSDART00000022694
ehd3
EH-domain containing 3
chr1_+_19764995 1.15 ENSDART00000138276
si:ch211-42i9.8
si:ch211-42i9.8
chr8_+_21225064 1.13 ENSDART00000129210
cry1ba
cryptochrome circadian clock 1ba
chr19_+_7549854 1.11 ENSDART00000138866
ENSDART00000151758
pbxip1a
pre-B-cell leukemia homeobox interacting protein 1a
chr21_+_43178831 1.10 ENSDART00000151512
aff4
AF4/FMR2 family, member 4
chr23_+_33963619 1.06 ENSDART00000140666
ENSDART00000084792
plpbp
pyridoxal phosphate binding protein
chr5_-_65153731 1.01 ENSDART00000171024
sh2d3cb
SH2 domain containing 3Cb
chr4_+_5341592 1.00 ENSDART00000123375
ENSDART00000067371
zgc:113263
zgc:113263
chr3_+_43373867 0.99 ENSDART00000159455
ENSDART00000172425
zfand2a
zinc finger, AN1-type domain 2A
chr16_-_35427060 0.97 ENSDART00000172294
ctps1b
CTP synthase 1b
chr3_-_26183699 0.97 ENSDART00000147517
ENSDART00000140731
si:ch211-11k18.4
si:ch211-11k18.4
chr23_+_9522781 0.96 ENSDART00000136486
osbpl2b
oxysterol binding protein-like 2b
chr14_+_3507326 0.92 ENSDART00000159326
gstp1
glutathione S-transferase pi 1
chr16_-_6849754 0.88 ENSDART00000149206
ENSDART00000149778
mbpb
myelin basic protein b
chr20_-_36617313 0.87 ENSDART00000172395
ENSDART00000152856
enah
enabled homolog (Drosophila)
chr1_-_354115 0.87 ENSDART00000141590
ENSDART00000098627
pros1
protein S
chr13_+_30035253 0.86 ENSDART00000181303
ENSDART00000057525
ENSDART00000136622
dnajb12a
DnaJ (Hsp40) homolog, subfamily B, member 12a
chr18_-_14879135 0.85 ENSDART00000099701
selenoo1
selenoprotein O1
chr21_-_32467799 0.85 ENSDART00000007675
ENSDART00000133099
zgc:123105
zgc:123105
chr16_+_39146696 0.85 ENSDART00000121756
ENSDART00000084381
sybu
syntabulin (syntaxin-interacting)
chr23_-_21763598 0.84 ENSDART00000145408
vps13d
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr17_-_23709347 0.84 ENSDART00000124661
papss2a
3'-phosphoadenosine 5'-phosphosulfate synthase 2a
chr21_-_32467099 0.79 ENSDART00000186354
zgc:123105
zgc:123105
chr10_+_18911152 0.78 ENSDART00000030205
bnip3lb
BCL2 interacting protein 3 like b
chr12_-_26383242 0.70 ENSDART00000152941
usp54b
ubiquitin specific peptidase 54b
chr16_-_19568388 0.68 ENSDART00000141616
abcb5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr14_-_30905288 0.67 ENSDART00000173449
ENSDART00000173451
si:ch211-126c2.4
si:ch211-126c2.4
chr12_-_23365737 0.67 ENSDART00000170376
mpp7a
membrane protein, palmitoylated 7a (MAGUK p55 subfamily member 7)
chr16_+_40954481 0.64 ENSDART00000058587
gbp
glycogen synthase kinase binding protein
chr7_+_38278860 0.62 ENSDART00000016265
lrp3
low density lipoprotein receptor-related protein 3
chr11_-_40147032 0.61 ENSDART00000052918
si:dkey-264d12.4
si:dkey-264d12.4
chr9_-_9225980 0.57 ENSDART00000180301
cbsb
cystathionine-beta-synthase b
chr14_+_1170968 0.56 ENSDART00000125203
ENSDART00000193575
hopx
HOP homeobox
chr14_+_23717165 0.56 ENSDART00000006373
ndfip1
Nedd4 family interacting protein 1
chr18_+_25546227 0.56 ENSDART00000085824
pex11a
peroxisomal biogenesis factor 11 alpha
chr19_-_45650994 0.55 ENSDART00000163504
trps1
trichorhinophalangeal syndrome I
chr22_+_10606573 0.53 ENSDART00000192638
rad54l2
RAD54 like 2
chr9_-_13871935 0.53 ENSDART00000146597
raph1a
Ras association (RalGDS/AF-6) and pleckstrin homology domains 1a
chr23_-_18981595 0.52 ENSDART00000147617
bcl2l1
bcl2-like 1
chr24_-_23784701 0.51 ENSDART00000090368
sgk3
serum/glucocorticoid regulated kinase family, member 3
chr25_-_12803723 0.51 ENSDART00000158787
ca5a
carbonic anhydrase Va
chr9_-_12888082 0.51 ENSDART00000133135
ENSDART00000134415
si:ch211-167j6.3
si:ch211-167j6.3
chr20_+_23083800 0.48 ENSDART00000132093
usp46
ubiquitin specific peptidase 46
chr6_+_16468776 0.45 ENSDART00000109151
ENSDART00000114667
zgc:161969
zgc:161969
chr20_-_44576949 0.39 ENSDART00000148639
ubxn2a
UBX domain protein 2A
chr5_-_54395488 0.39 ENSDART00000160781
zmynd19
zinc finger, MYND-type containing 19
chr23_+_19590006 0.39 ENSDART00000021231
slmapb
sarcolemma associated protein b
chr10_-_25591194 0.34 ENSDART00000131640
tiam1a
T cell lymphoma invasion and metastasis 1a
chr17_-_8268406 0.28 ENSDART00000149873
ENSDART00000064668
ENSDART00000148403
ahi1
Abelson helper integration site 1
chr22_+_15973122 0.27 ENSDART00000144545
rc3h1a
ring finger and CCCH-type domains 1a
chr18_-_2549198 0.25 ENSDART00000186516
CABZ01070631.1

chr14_+_34971554 0.25 ENSDART00000184271
rnf145a
ring finger protein 145a
chr4_+_21866851 0.25 ENSDART00000177640
acss3
acyl-CoA synthetase short chain family member 3
chr15_+_21882419 0.24 ENSDART00000157216
si:dkey-103g5.4
si:dkey-103g5.4
chr5_+_69808763 0.24 ENSDART00000143482
fsd1l
fibronectin type III and SPRY domain containing 1-like
chr17_+_49281597 0.23 ENSDART00000155599
zgc:113176
zgc:113176
chr25_-_7887274 0.23 ENSDART00000157276
si:ch73-151m17.5
si:ch73-151m17.5
chr20_+_1121458 0.19 ENSDART00000064472
pnrc1
proline-rich nuclear receptor coactivator 1
chr9_+_46644633 0.19 ENSDART00000160285
slc4a3
solute carrier family 4 (anion exchanger), member 3
chr24_-_39772045 0.19 ENSDART00000087441
GFOD1
si:ch211-276f18.2
chr3_-_21348478 0.17 ENSDART00000114906
fam171a2a
family with sequence similarity 171, member A2a
chr15_-_31419805 0.16 ENSDART00000060111
or111-11
odorant receptor, family D, subfamily 111, member 11
chr10_+_22771176 0.16 ENSDART00000192046
tmem88a
transmembrane protein 88 a
chr25_+_34014523 0.15 ENSDART00000182856
anxa2a
annexin A2a
chr5_+_26121393 0.10 ENSDART00000002221
bco2l
beta-carotene 15, 15-dioxygenase 2, like
chr21_+_21374277 0.09 ENSDART00000079431
rtn2b
reticulon 2b
chr22_-_13165186 0.08 ENSDART00000105762
ahr2
aryl hydrocarbon receptor 2
chr4_-_12914163 0.06 ENSDART00000140002
ENSDART00000145917
ENSDART00000141355
ENSDART00000067135
msrb3
methionine sulfoxide reductase B3
chr21_-_39566854 0.05 ENSDART00000020174
dynll2b
dynein, light chain, LC8-type 2b
chr3_+_24094581 0.04 ENSDART00000138270
ENSDART00000131509
copz2
coatomer protein complex, subunit zeta 2
chr24_+_18948665 0.03 ENSDART00000106186
prex2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr24_+_28561038 0.03 ENSDART00000147063
abca4a
ATP-binding cassette, sub-family A (ABC1), member 4a
chr6_-_48347724 0.02 ENSDART00000046973
capza1a
capping protein (actin filament) muscle Z-line, alpha 1a
chr4_+_21867522 0.02 ENSDART00000140400
acss3
acyl-CoA synthetase short chain family member 3
chr9_-_44953664 0.02 ENSDART00000188558
ENSDART00000185210
vil1
villin 1
chr9_-_44953349 0.01 ENSDART00000135156
vil1
villin 1

Network of associatons between targets according to the STRING database.

First level regulatory network of tefa+tefb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.9 GO:0098881 exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967)
0.3 0.9 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.3 0.9 GO:0042730 fibrinolysis(GO:0042730)
0.3 0.8 GO:0050427 sulfate assimilation(GO:0000103) purine ribonucleoside bisphosphate metabolic process(GO:0034035) purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428)
0.2 1.0 GO:0044210 'de novo' CTP biosynthetic process(GO:0044210)
0.2 1.7 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.2 0.7 GO:0046689 response to mercury ion(GO:0046689) detoxification of mercury ion(GO:0050787)
0.2 0.8 GO:0060074 synapse maturation(GO:0060074)
0.2 0.6 GO:0050666 regulation of sulfur amino acid metabolic process(GO:0031335) regulation of homocysteine metabolic process(GO:0050666)
0.2 1.1 GO:2001106 regulation of guanyl-nucleotide exchange factor activity(GO:1905097) regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.2 0.8 GO:0045822 negative regulation of heart contraction(GO:0045822) negative regulation of blood circulation(GO:1903523)
0.1 0.8 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.1 0.6 GO:0016559 peroxisome fission(GO:0016559)
0.1 1.0 GO:1904356 regulation of telomere maintenance via telomere lengthening(GO:1904356)
0.1 1.3 GO:0007520 myoblast fusion(GO:0007520)
0.1 0.5 GO:0032228 regulation of synaptic transmission, GABAergic(GO:0032228)
0.1 0.2 GO:1901295 negative regulation of striated muscle cell differentiation(GO:0051154) negative regulation of cardiac muscle tissue development(GO:0055026) cardiac muscle cell fate commitment(GO:0060923) canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:0061317) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901296) negative regulation of cardiocyte differentiation(GO:1905208) negative regulation of cardiac muscle cell differentiation(GO:2000726)
0.0 1.0 GO:0033138 positive regulation of peptidyl-serine phosphorylation(GO:0033138)
0.0 4.7 GO:0008360 regulation of cell shape(GO:0008360)
0.0 0.9 GO:0051788 response to misfolded protein(GO:0051788) cellular response to misfolded protein(GO:0071218)
0.0 0.5 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.0 0.1 GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902175) negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902176)
0.0 1.7 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.0 0.3 GO:0044458 motile cilium assembly(GO:0044458)
0.0 1.1 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.2 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.0 0.4 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.0 0.9 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.6 GO:0031398 positive regulation of protein ubiquitination(GO:0031398)
0.0 0.1 GO:0030091 protein repair(GO:0030091)
0.0 2.3 GO:0016197 endosomal transport(GO:0016197)
0.0 0.2 GO:0086001 cardiac muscle cell action potential(GO:0086001)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.7 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.2 1.0 GO:0097268 cytoophidium(GO:0097268)
0.1 1.1 GO:0032783 ELL-EAF complex(GO:0032783)
0.1 2.9 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.1 0.6 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.1 1.0 GO:0070187 telosome(GO:0070187)
0.0 1.1 GO:0060170 ciliary membrane(GO:0060170)
0.0 0.9 GO:0043209 myelin sheath(GO:0043209)
0.0 0.8 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 1.3 GO:0005741 mitochondrial outer membrane(GO:0005741)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.7 GO:0004478 methionine adenosyltransferase activity(GO:0004478)
0.3 0.8 GO:0004781 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.2 1.0 GO:0003883 CTP synthase activity(GO:0003883)
0.1 0.6 GO:0004122 cystathionine beta-synthase activity(GO:0004122)
0.1 0.6 GO:0050699 WW domain binding(GO:0050699)
0.1 0.9 GO:0005522 profilin binding(GO:0005522)
0.1 0.9 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 0.9 GO:0030544 Hsp70 protein binding(GO:0030544)
0.1 0.9 GO:0070566 adenylyltransferase activity(GO:0070566)
0.1 0.3 GO:0050218 propionate-CoA ligase activity(GO:0050218)
0.0 2.9 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.5 GO:0043028 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028)
0.0 1.4 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.8 GO:0019894 kinesin binding(GO:0019894)
0.0 0.3 GO:0035613 RNA stem-loop binding(GO:0035613)
0.0 1.0 GO:0015248 sterol transporter activity(GO:0015248)
0.0 1.2 GO:0016307 phosphatidylinositol phosphate kinase activity(GO:0016307)
0.0 1.0 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 1.2 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.0 0.2 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.5 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.6 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 1.1 GO:0030170 pyridoxal phosphate binding(GO:0030170)
0.0 0.5 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 0.1 GO:0055102 phospholipase inhibitor activity(GO:0004859) lipase inhibitor activity(GO:0055102)
0.0 0.1 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 0.5 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.9 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.1 1.3 REACTOME ARMS MEDIATED ACTIVATION Genes involved in ARMS-mediated activation
0.1 0.9 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.1 0.5 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.1 1.3 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.1 0.9 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.5 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.7 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport