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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for tfap2a+tfap2c

Z-value: 0.85

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Transcription factors associated with tfap2a+tfap2c

Gene Symbol Gene ID Gene Info
tfap2c
ENSDARG00000040606 transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
tfap2a
ENSDARG00000059279 transcription factor AP-2 alpha

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tfap2cdr11_v1_chr6_+_56141852_561418520.571.5e-02Click!
tfap2adr11_v1_chr24_-_8732519_8732519-0.126.4e-01Click!

Activity profile of tfap2a+tfap2c motif

Sorted Z-values of tfap2a+tfap2c motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_54607166 2.88 ENSDART00000021977
dnmt1
DNA (cytosine-5-)-methyltransferase 1
chr24_-_21903588 2.27 ENSDART00000180991
spata13
spermatogenesis associated 13
chr24_-_21903360 2.26 ENSDART00000091252
spata13
spermatogenesis associated 13
chr15_+_6459847 1.96 ENSDART00000157250
ENSDART00000065824
bace2
beta-site APP-cleaving enzyme 2
chr5_+_25736979 1.79 ENSDART00000175959
abhd17b
abhydrolase domain containing 17B
chr16_+_26846495 1.76 ENSDART00000078124
trim35-29
tripartite motif containing 35-29
chr2_+_1988036 1.56 ENSDART00000155956
ssx2ipa
synovial sarcoma, X breakpoint 2 interacting protein a
chr3_-_26244256 1.53 ENSDART00000103741
ppp4ca
protein phosphatase 4, catalytic subunit a
chr1_+_16548733 1.52 ENSDART00000048855
mtus1b
microtubule associated tumor suppressor 1b
chr7_+_32693890 1.50 ENSDART00000121972
slc39a13
solute carrier family 39 (zinc transporter), member 13
chr3_+_3454610 1.31 ENSDART00000024900
zgc:165453
zgc:165453
chr3_+_26244353 1.31 ENSDART00000103733
atad5a
ATPase family, AAA domain containing 5a
chr11_+_14333441 1.31 ENSDART00000171969
ptbp1b
polypyrimidine tract binding protein 1b
chr1_-_25486471 1.26 ENSDART00000134200
ENSDART00000141892
ENSDART00000102501
arfip1
ADP-ribosylation factor interacting protein 1 (arfaptin 1)
chr11_+_14321113 1.24 ENSDART00000039822
ENSDART00000137347
ENSDART00000132997
ptbp1b
polypyrimidine tract binding protein 1b
chr3_-_35865040 1.23 ENSDART00000102952
suz12a
SUZ12 polycomb repressive complex 2a subunit
chr11_+_31323746 1.23 ENSDART00000180220
ENSDART00000189937
sipa1l2
signal-induced proliferation-associated 1 like 2
chr18_+_34181655 1.20 ENSDART00000130831
ENSDART00000109535
gmps
guanine monophosphate synthase
chr8_+_48942470 1.19 ENSDART00000005464
ENSDART00000132035
rer1
retention in endoplasmic reticulum sorting receptor 1
chr1_+_49878000 1.13 ENSDART00000047876
lef1
lymphoid enhancer-binding factor 1
chr5_+_63302660 1.11 ENSDART00000142131
si:ch73-376l24.2
si:ch73-376l24.2
chr11_+_31324335 1.07 ENSDART00000088093
sipa1l2
signal-induced proliferation-associated 1 like 2
chr1_+_27977297 1.02 ENSDART00000180692
ENSDART00000166819
sugt1
SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
chr3_-_55328548 1.01 ENSDART00000082944
dock6
dedicator of cytokinesis 6
chr7_+_39011852 0.92 ENSDART00000093009
dgkza
diacylglycerol kinase, zeta a
chr3_-_26805455 0.91 ENSDART00000180648
pigq
phosphatidylinositol glycan anchor biosynthesis, class Q
chr18_-_15551360 0.88 ENSDART00000159915
ENSDART00000172690
ppfibp1b
PTPRF interacting protein, binding protein 1b (liprin beta 1)
chr5_+_6672870 0.87 ENSDART00000126598
pxna
paxillin a
chr16_+_26601364 0.87 ENSDART00000087537
epb41l4b
erythrocyte membrane protein band 4.1 like 4B
chr8_-_26792912 0.85 ENSDART00000139787
kazna
kazrin, periplakin interacting protein a
chr14_+_14806851 0.84 ENSDART00000169235
fhdc2
FH2 domain containing 2
chr8_+_48943009 0.83 ENSDART00000180763
rer1
retention in endoplasmic reticulum sorting receptor 1
chr18_+_50650512 0.78 ENSDART00000161022
si:dkey-151j17.4
si:dkey-151j17.4
chr2_+_30547018 0.78 ENSDART00000193747
ankrd33bb
ankyrin repeat domain 33Bb
chr11_-_28050559 0.77 ENSDART00000136859
ece1
endothelin converting enzyme 1
chr23_-_27152866 0.74 ENSDART00000141305
si:dkey-157g16.6
si:dkey-157g16.6
chr8_-_11004726 0.70 ENSDART00000192594
ENSDART00000020116
trim33
tripartite motif containing 33
chr1_+_58990121 0.70 ENSDART00000171654
CABZ01083166.1

chr20_+_4157815 0.68 ENSDART00000113132
gnpat
glyceronephosphate O-acyltransferase
chr13_-_36566260 0.68 ENSDART00000030133
synj2bp
synaptojanin 2 binding protein
chr15_+_44929497 0.62 ENSDART00000111373
pdgfd
platelet derived growth factor d
chr2_+_11206317 0.62 ENSDART00000144982
lhx8a
LIM homeobox 8a
chr14_+_14806692 0.62 ENSDART00000193050
fhdc2
FH2 domain containing 2
chr11_+_30253968 0.62 ENSDART00000157272
ENSDART00000003475
ppef1
protein phosphatase, EF-hand calcium binding domain 1
chr14_-_45464112 0.60 ENSDART00000173209
ehd1a
EH-domain containing 1a
chr14_+_29200772 0.57 ENSDART00000166608
TENM2
si:dkey-34l15.2
chr24_-_37272116 0.56 ENSDART00000022999
ube2ib
ubiquitin-conjugating enzyme E2Ib
chr7_-_34265481 0.54 ENSDART00000173596
si:ch211-98n17.5
si:ch211-98n17.5
chr2_+_11205795 0.53 ENSDART00000019078
lhx8a
LIM homeobox 8a
chr19_-_5369486 0.52 ENSDART00000105004
krt17
keratin 17
chr24_+_31374324 0.49 ENSDART00000172335
ENSDART00000163162
cpne3
copine III
chr15_-_24960730 0.48 ENSDART00000109990
ENSDART00000186706
abhd15a
abhydrolase domain containing 15a
chr14_+_29609245 0.47 ENSDART00000043058
TENM2
si:dkey-34l15.2
chr4_-_21466480 0.45 ENSDART00000139962
pawr
PRKC, apoptosis, WT1, regulator
chr23_-_35347714 0.43 ENSDART00000161770
ENSDART00000165615
cpne9
copine family member IX
chr7_-_15252540 0.43 ENSDART00000173072
ENSDART00000125258
si:dkey-172h23.2
si:dkey-172h23.2
chr24_+_21346796 0.38 ENSDART00000126519
shisa2b
shisa family member 2b
chr10_-_5135788 0.31 ENSDART00000108587
ENSDART00000138537
sec31a
SEC31 homolog A, COPII coat complex component
chr19_-_30510930 0.26 ENSDART00000088760
ENSDART00000181043
bag6l
BCL2 associated athanogene 6, like
chr1_-_45888608 0.25 ENSDART00000139219
pnpla6
patatin-like phospholipase domain containing 6
chr23_-_21215520 0.23 ENSDART00000143206
megf6a
multiple EGF-like-domains 6a
chr12_+_48744016 0.23 ENSDART00000175518
LO017648.1

chr3_+_34846201 0.22 ENSDART00000055263
itga3a
integrin, alpha 3a
chr8_-_4789034 0.21 ENSDART00000082256
ciao1
cytosolic iron-sulfur assembly component 1
chr8_-_13211527 0.20 ENSDART00000090541
si:ch73-61d6.3
si:ch73-61d6.3
chr23_+_37323962 0.20 ENSDART00000102881
fam43b
family with sequence similarity 43, member B
chr16_-_46393154 0.19 ENSDART00000132154
si:ch73-59c19.1
si:ch73-59c19.1
chr18_-_31969939 0.16 ENSDART00000171516
olfcs1
olfactory receptor C family, s1
chr21_-_45186431 0.11 ENSDART00000193449
si:ch73-269m14.2
si:ch73-269m14.2
chr5_+_16580739 0.11 ENSDART00000135140
htr7c
5-hydroxytryptamine (serotonin) receptor 7c
chr20_-_34292285 0.11 ENSDART00000020389
hmcn1
hemicentin 1
chr24_-_36723116 0.10 ENSDART00000088204
si:ch73-334d15.1
si:ch73-334d15.1
chr20_-_15089738 0.07 ENSDART00000164552
si:dkey-239i20.2
si:dkey-239i20.2
chr20_-_2725930 0.07 ENSDART00000081643
akirin2
akirin 2
chr7_-_2116512 0.07 ENSDART00000098148
si:cabz01007802.1
si:cabz01007802.1
chr24_-_6898302 0.07 ENSDART00000158646
dpp6a
dipeptidyl-peptidase 6a
chr20_-_2725594 0.06 ENSDART00000152120
akirin2
akirin 2
chr7_-_23563092 0.06 ENSDART00000132275
gpr185b
G protein-coupled receptor 185 b
chr2_+_28995776 0.06 ENSDART00000138733
cdh12a
cadherin 12, type 2a (N-cadherin 2)
chr2_-_43635777 0.06 ENSDART00000148633
itgb1b.1
integrin, beta 1b.1
chr22_+_5971404 0.06 ENSDART00000122153
BX322587.1

chr14_+_918287 0.06 ENSDART00000167066
CU462913.1

chr20_-_34292607 0.04 ENSDART00000144705
hmcn1
hemicentin 1
chr10_-_36927594 0.04 ENSDART00000162046
sez6a
seizure related 6 homolog a
chr5_+_61799629 0.03 ENSDART00000113508
hnrnpul1l
heterogeneous nuclear ribonucleoprotein U-like 1 like
chr5_-_37933983 0.02 ENSDART00000185364
scn4bb
sodium channel, voltage-gated, type IV, beta b
chr4_-_68853063 0.01 ENSDART00000162386
si:dkey-264f17.1
si:dkey-264f17.1
chr4_-_16345227 0.01 ENSDART00000079521
kera
keratocan
chr10_+_21793670 0.00 ENSDART00000168918
pcdh1gc6
protocadherin 1 gamma c 6

Network of associatons between targets according to the STRING database.

First level regulatory network of tfap2a+tfap2c

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.9 GO:0032776 DNA methylation on cytosine(GO:0032776)
0.3 2.0 GO:0006621 protein retention in ER lumen(GO:0006621)
0.2 0.7 GO:0008611 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) cellular lipid biosynthetic process(GO:0097384) ether biosynthetic process(GO:1901503)
0.2 1.1 GO:0060784 regulation of cell proliferation involved in tissue homeostasis(GO:0060784)
0.2 2.0 GO:0050435 beta-amyloid metabolic process(GO:0050435)
0.1 0.6 GO:0036306 embryonic heart tube elongation(GO:0036306)
0.1 1.8 GO:0002084 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.1 1.2 GO:0046037 GMP biosynthetic process(GO:0006177) GMP metabolic process(GO:0046037)
0.1 0.7 GO:0048569 post-embryonic organ development(GO:0048569)
0.1 1.1 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.1 1.5 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.1 0.6 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.1 1.5 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.1 0.9 GO:0061055 myotome development(GO:0061055)
0.1 1.3 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)
0.1 0.8 GO:0016486 peptide hormone processing(GO:0016486)
0.0 1.2 GO:0021884 forebrain neuron development(GO:0021884)
0.0 0.9 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 1.3 GO:0050821 protein stabilization(GO:0050821)
0.0 0.2 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 0.9 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 0.4 GO:0043114 regulation of vascular permeability(GO:0043114)
0.0 0.3 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 2.3 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.2 GO:0046470 phosphatidylcholine metabolic process(GO:0046470)
0.0 0.7 GO:0097120 receptor localization to synapse(GO:0097120)
0.0 0.9 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 2.6 GO:0043484 regulation of RNA splicing(GO:0043484)
0.0 0.6 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.9 GO:0007528 neuromuscular junction development(GO:0007528)
0.0 0.6 GO:0050906 detection of stimulus involved in sensory perception(GO:0050906)
0.0 1.3 GO:0010466 negative regulation of peptidase activity(GO:0010466)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 1.2 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 0.2 GO:0097361 CIA complex(GO:0097361)
0.1 1.3 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 1.1 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 0.3 GO:0071818 BAT3 complex(GO:0071818)
0.0 2.0 GO:0031228 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.0 0.7 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.6 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 2.0 GO:0005802 trans-Golgi network(GO:0005802)
0.0 1.6 GO:0036064 ciliary basal body(GO:0036064)
0.0 0.7 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.3 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.9 GO:0048786 presynaptic active zone(GO:0048786)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.9 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.1 0.6 GO:0061656 SUMO conjugating enzyme activity(GO:0061656)
0.1 0.9 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.1 1.3 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.1 2.0 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.1 1.2 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.1 1.8 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 0.6 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.1 0.5 GO:0034338 short-chain carboxylesterase activity(GO:0034338)
0.1 1.1 GO:0008301 DNA binding, bending(GO:0008301)
0.1 1.5 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 0.7 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.0 0.4 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.9 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 2.1 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.3 GO:0070628 proteasome binding(GO:0070628)
0.0 1.2 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 0.5 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 0.2 GO:0004622 lysophospholipase activity(GO:0004622)
0.0 0.1 GO:0098634 C-X3-C chemokine binding(GO:0019960) protein binding involved in cell-matrix adhesion(GO:0098634) collagen binding involved in cell-matrix adhesion(GO:0098639)
0.0 4.2 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 1.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.5 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 2.9 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 0.6 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 1.0 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.4 PID CERAMIDE PATHWAY Ceramide signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 0.9 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.7 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.7 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.3 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 1.0 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production