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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for tfap2e

Z-value: 0.69

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Transcription factors associated with tfap2e

Gene Symbol Gene ID Gene Info
tfap2e
ENSDARG00000008861 transcription factor AP-2 epsilon

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tfap2edr11_v1_chr19_-_47456787_47456787-0.823.7e-05Click!

Activity profile of tfap2e motif

Sorted Z-values of tfap2e motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_54607166 2.17 ENSDART00000021977
dnmt1
DNA (cytosine-5-)-methyltransferase 1
chr14_-_34605607 1.87 ENSDART00000191608
afap1l1a
actin filament associated protein 1-like 1a
chr24_-_21903588 1.62 ENSDART00000180991
spata13
spermatogenesis associated 13
chr24_-_21903360 1.60 ENSDART00000091252
spata13
spermatogenesis associated 13
chr14_-_34605804 1.49 ENSDART00000144547
afap1l1a
actin filament associated protein 1-like 1a
chr2_-_15041846 1.44 ENSDART00000139050
si:dkey-10f21.4
si:dkey-10f21.4
chr19_+_2835240 1.38 ENSDART00000190838
CDCP1
CUB domain containing protein 1
chr20_+_6533260 1.34 ENSDART00000135005
ENSDART00000166356
si:ch211-191a24.4
si:ch211-191a24.4
chr19_+_32979331 1.12 ENSDART00000078066
spire1a
spire-type actin nucleation factor 1a
chr5_+_63302660 1.11 ENSDART00000142131
si:ch73-376l24.2
si:ch73-376l24.2
chr7_+_32693890 1.10 ENSDART00000121972
slc39a13
solute carrier family 39 (zinc transporter), member 13
chr23_+_27778670 1.07 ENSDART00000053863
kmt2d
lysine (K)-specific methyltransferase 2D
chr2_+_1988036 1.02 ENSDART00000155956
ssx2ipa
synovial sarcoma, X breakpoint 2 interacting protein a
chr8_+_48942470 1.00 ENSDART00000005464
ENSDART00000132035
rer1
retention in endoplasmic reticulum sorting receptor 1
chr18_+_34181655 1.00 ENSDART00000130831
ENSDART00000109535
gmps
guanine monophosphate synthase
chr19_-_31707892 0.99 ENSDART00000088427
ripor2
RHO family interacting cell polarization regulator 2
chr23_-_18668836 0.97 ENSDART00000138792
ENSDART00000051182
arhgap4b
Rho GTPase activating protein 4b
chr3_-_55328548 0.93 ENSDART00000082944
dock6
dedicator of cytokinesis 6
chr5_+_25736979 0.92 ENSDART00000175959
abhd17b
abhydrolase domain containing 17B
chr13_+_16342926 0.87 ENSDART00000105496
ENSDART00000124710
dlg5a
discs, large homolog 5a (Drosophila)
chr7_+_39011852 0.85 ENSDART00000093009
dgkza
diacylglycerol kinase, zeta a
chr1_-_25486471 0.82 ENSDART00000134200
ENSDART00000141892
ENSDART00000102501
arfip1
ADP-ribosylation factor interacting protein 1 (arfaptin 1)
chr18_+_50650512 0.81 ENSDART00000161022
si:dkey-151j17.4
si:dkey-151j17.4
chr6_+_153146 0.81 ENSDART00000097468
zglp1
zinc finger, GATA-like protein 1
chr11_+_31323746 0.78 ENSDART00000180220
ENSDART00000189937
sipa1l2
signal-induced proliferation-associated 1 like 2
chr11_+_14333441 0.78 ENSDART00000171969
ptbp1b
polypyrimidine tract binding protein 1b
chr8_+_48943009 0.75 ENSDART00000180763
rer1
retention in endoplasmic reticulum sorting receptor 1
chr1_+_16548733 0.74 ENSDART00000048855
mtus1b
microtubule associated tumor suppressor 1b
chr2_+_36616830 0.72 ENSDART00000169547
ENSDART00000098417
pak2a
p21 protein (Cdc42/Rac)-activated kinase 2a
chr14_-_31465905 0.69 ENSDART00000173108
gpc3
glypican 3
chr11_+_31324335 0.68 ENSDART00000088093
sipa1l2
signal-induced proliferation-associated 1 like 2
chr2_+_30547018 0.67 ENSDART00000193747
ankrd33bb
ankyrin repeat domain 33Bb
chr14_+_29609245 0.60 ENSDART00000043058
TENM2
si:dkey-34l15.2
chr25_-_19574146 0.59 ENSDART00000156811
si:ch211-59o9.10
si:ch211-59o9.10
chr3_+_3454610 0.58 ENSDART00000024900
zgc:165453
zgc:165453
chr8_-_11004726 0.55 ENSDART00000192594
ENSDART00000020116
trim33
tripartite motif containing 33
chr3_+_25990052 0.54 ENSDART00000007398
gcat
glycine C-acetyltransferase
chr9_-_2892045 0.52 ENSDART00000137201
cdca7a
cell division cycle associated 7a
chr24_+_31374324 0.50 ENSDART00000172335
ENSDART00000163162
cpne3
copine III
chr5_+_27267186 0.50 ENSDART00000182238
ENSDART00000087857
unc5db
unc-5 netrin receptor Db
chr9_-_2892250 0.48 ENSDART00000140695
cdca7a
cell division cycle associated 7a
chr11_+_30253968 0.47 ENSDART00000157272
ENSDART00000003475
ppef1
protein phosphatase, EF-hand calcium binding domain 1
chr7_+_39011355 0.47 ENSDART00000173855
dgkza
diacylglycerol kinase, zeta a
chr19_-_5369486 0.47 ENSDART00000105004
krt17
keratin 17
chr10_-_5135788 0.41 ENSDART00000108587
ENSDART00000138537
sec31a
SEC31 homolog A, COPII coat complex component
chr6_-_25369295 0.41 ENSDART00000191475
PKN2 (1 of many)
zgc:153916
chr23_-_35347714 0.41 ENSDART00000161770
ENSDART00000165615
cpne9
copine family member IX
chr11_-_28050559 0.40 ENSDART00000136859
ece1
endothelin converting enzyme 1
chr15_+_44929497 0.38 ENSDART00000111373
pdgfd
platelet derived growth factor d
chr12_+_19036380 0.37 ENSDART00000153086
ENSDART00000181060
kctd17
potassium channel tetramerization domain containing 17
chr25_+_11281970 0.37 ENSDART00000180094
AKAP13
si:dkey-187e18.1
chr14_+_26437891 0.34 ENSDART00000175459
gpr137
G protein-coupled receptor 137
chr14_-_26704829 0.34 ENSDART00000078563
neurog1
neurogenin 1
chr19_+_42660158 0.33 ENSDART00000018328
fbxl2
F-box and leucine-rich repeat protein 2
chr7_-_15252540 0.33 ENSDART00000173072
ENSDART00000125258
si:dkey-172h23.2
si:dkey-172h23.2
chr5_-_14509137 0.32 ENSDART00000180742
si:ch211-244o22.2
si:ch211-244o22.2
chr6_-_39313027 0.32 ENSDART00000012644
krt4
keratin 4
chr17_+_34186632 0.32 ENSDART00000014306
mpp5a
membrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5)
chr10_-_2526526 0.32 ENSDART00000191726
ENSDART00000192767
CU856539.1

chr6_+_28203 0.31 ENSDART00000191561
CZQB01141835.1

chr2_+_11206317 0.30 ENSDART00000144982
lhx8a
LIM homeobox 8a
chr22_+_15633013 0.24 ENSDART00000188095
ENSDART00000048763
CABZ01090041.1

chr19_-_30510930 0.23 ENSDART00000088760
ENSDART00000181043
bag6l
BCL2 associated athanogene 6, like
chr4_+_77966055 0.23 ENSDART00000174203
ENSDART00000130100
ENSDART00000080665
ENSDART00000174317
ENSDART00000190123
zgc:113921
zgc:113921
chr3_-_49163683 0.19 ENSDART00000166146
dnajb1a
DnaJ (Hsp40) homolog, subfamily B, member 1a
chr2_+_11205795 0.19 ENSDART00000019078
lhx8a
LIM homeobox 8a
chr23_-_4930229 0.19 ENSDART00000189456
ngfa
nerve growth factor a (beta polypeptide)
chr20_-_2725930 0.16 ENSDART00000081643
akirin2
akirin 2
chr16_-_17162485 0.14 ENSDART00000123011
iffo1b
intermediate filament family orphan 1b
chr23_+_37323962 0.13 ENSDART00000102881
fam43b
family with sequence similarity 43, member B
chr19_-_10395683 0.11 ENSDART00000109488
zgc:194578
zgc:194578
chr11_+_13067028 0.09 ENSDART00000186126
zfyve9b
zinc finger, FYVE domain containing 9b
chr5_-_26936861 0.08 ENSDART00000191032
htra4
HtrA serine peptidase 4
chr21_+_39941875 0.08 ENSDART00000190414
slc47a1
solute carrier family 47 (multidrug and toxin extrusion), member 1
chr21_+_39941559 0.06 ENSDART00000189718
ENSDART00000160875
ENSDART00000135235
slc47a1
solute carrier family 47 (multidrug and toxin extrusion), member 1
chr16_+_36906693 0.06 ENSDART00000160645
si:ch73-215d9.1
si:ch73-215d9.1
chr25_+_5249513 0.05 ENSDART00000126814
CABZ01039863.1

chr18_+_34478959 0.05 ENSDART00000059394
kcnab1a
potassium voltage-gated channel, shaker-related subfamily, beta member 1 a
chr7_-_2116512 0.02 ENSDART00000098148
si:cabz01007802.1
si:cabz01007802.1
chr18_-_47103131 0.02 ENSDART00000188553
CABZ01039304.1

chr22_+_9418502 0.01 ENSDART00000189702
si:ch211-11p18.6
si:ch211-11p18.6
chr1_-_53476758 0.01 ENSDART00000074221
b3gnt2a
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2a
chr20_-_15089738 0.01 ENSDART00000164552
si:dkey-239i20.2
si:dkey-239i20.2
chr5_+_38673168 0.01 ENSDART00000135267
si:dkey-58f10.12
si:dkey-58f10.12
chr4_-_1914228 0.01 ENSDART00000087835
ano6
anoctamin 6
chr3_-_8160457 0.01 ENSDART00000183379
si:ch211-51i16.1
si:ch211-51i16.1
chr19_+_1184878 0.01 ENSDART00000163539
scrt1a
scratch family zinc finger 1a

Network of associatons between targets according to the STRING database.

First level regulatory network of tfap2e

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.2 GO:0032776 DNA methylation on cytosine(GO:0032776)
0.3 1.0 GO:2000402 response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869) negative regulation of lymphocyte migration(GO:2000402) negative regulation of T cell migration(GO:2000405)
0.3 1.8 GO:0006621 protein retention in ER lumen(GO:0006621)
0.1 1.1 GO:0033206 meiotic cytokinesis(GO:0033206) polar body extrusion after meiotic divisions(GO:0040038)
0.1 0.4 GO:0045724 positive regulation of cilium assembly(GO:0045724)
0.1 1.1 GO:0003422 growth plate cartilage morphogenesis(GO:0003422) chondrocyte intercalation involved in growth plate cartilage morphogenesis(GO:0003428)
0.1 1.0 GO:0006177 GMP biosynthetic process(GO:0006177) GMP metabolic process(GO:0046037)
0.1 0.7 GO:0060976 coronary vasculature development(GO:0060976)
0.1 1.1 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.1 0.3 GO:0016332 establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
0.1 0.9 GO:0002084 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.1 0.5 GO:0048569 post-embryonic organ development(GO:0048569)
0.1 0.3 GO:0048909 dorsal spinal cord development(GO:0021516) anterior lateral line nerve development(GO:0048909)
0.1 0.5 GO:0006566 threonine metabolic process(GO:0006566) threonine catabolic process(GO:0006567)
0.1 1.3 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.1 1.1 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.1 0.4 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.0 0.5 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.0 0.8 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)
0.0 1.0 GO:0048538 thymus development(GO:0048538)
0.0 0.3 GO:1904263 positive regulation of TORC1 signaling(GO:1904263)
0.0 0.4 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.3 GO:0035306 positive regulation of dephosphorylation(GO:0035306) positive regulation of protein dephosphorylation(GO:0035307)
0.0 0.4 GO:0016486 peptide hormone processing(GO:0016486)
0.0 0.2 GO:0071816 tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0 0.5 GO:0021884 forebrain neuron development(GO:0021884)
0.0 1.4 GO:0055088 lipid homeostasis(GO:0055088)
0.0 0.9 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 0.2 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 0.8 GO:0048599 oocyte development(GO:0048599)
0.0 1.0 GO:0030336 negative regulation of cell migration(GO:0030336)
0.0 0.0 GO:1902260 negative regulation of potassium ion transmembrane transporter activity(GO:1901017) negative regulation of potassium ion transmembrane transport(GO:1901380) negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0060171 stereocilium membrane(GO:0060171)
0.2 3.4 GO:0002102 podosome(GO:0002102)
0.1 1.1 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.8 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.2 GO:0071818 BAT3 complex(GO:0071818)
0.0 1.1 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.3 GO:0045095 keratin filament(GO:0045095)
0.0 0.7 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 1.8 GO:0030173 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.0 0.4 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.3 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 0.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.0 GO:0036064 ciliary basal body(GO:0036064)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0071889 14-3-3 protein binding(GO:0071889)
0.2 2.2 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.1 0.5 GO:0016453 C-acetyltransferase activity(GO:0016453)
0.1 0.8 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.1 1.0 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.1 3.4 GO:0017124 SH3 domain binding(GO:0017124)
0.1 1.3 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 0.5 GO:0005042 netrin receptor activity(GO:0005042)
0.0 0.3 GO:0070888 E-box binding(GO:0070888)
0.0 1.1 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.9 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.4 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 1.1 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.3 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.5 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 0.4 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.2 GO:0070628 proteasome binding(GO:0070628)
0.0 0.2 GO:0005165 nerve growth factor receptor binding(GO:0005163) neurotrophin receptor binding(GO:0005165)
0.0 0.2 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 0.5 GO:0030145 manganese ion binding(GO:0030145)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.1 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 2.2 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 0.4 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.4 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.7 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.5 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.4 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC