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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for tlx1

Z-value: 0.44

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Transcription factors associated with tlx1

Gene Symbol Gene ID Gene Info
tlx1
ENSDARG00000003965 T cell leukemia homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tlx1dr11_v1_chr13_-_28272299_282722990.135.9e-01Click!

Activity profile of tlx1 motif

Sorted Z-values of tlx1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_17232372 1.45 ENSDART00000135679
rab36
RAB36, member RAS oncogene family
chr19_+_9004256 1.42 ENSDART00000186401
ENSDART00000091443
si:ch211-81a5.1
si:ch211-81a5.1
chr25_+_13158549 0.94 ENSDART00000167804
si:dkeyp-50b9.1
si:dkeyp-50b9.1
chr13_+_37040789 0.87 ENSDART00000063412
esr2b
estrogen receptor 2b
chr6_+_26346686 0.80 ENSDART00000154183
dzip1l
DAZ interacting zinc finger protein 1-like
chr7_-_35126374 0.77 ENSDART00000141211
hsd11b2
hydroxysteroid (11-beta) dehydrogenase 2
chr22_+_22888 0.67 ENSDART00000082471
mfap2
microfibril associated protein 2
chr3_+_57038033 0.50 ENSDART00000162930
bahcc1a
BAH domain and coiled-coil containing 1a
chr2_-_17827983 0.50 ENSDART00000166518
ptprfb
protein tyrosine phosphatase, receptor type, f, b
chr13_+_15682803 0.49 ENSDART00000188063
CR931980.1

chr7_+_14291323 0.47 ENSDART00000053521
rhcga
Rh family, C glycoprotein a
chr2_-_21618629 0.46 ENSDART00000027587
ralab
v-ral simian leukemia viral oncogene homolog Ab (ras related)
chr4_-_16406737 0.45 ENSDART00000013085
dcn
decorin
chr16_+_23397785 0.44 ENSDART00000148961
s100a10b
S100 calcium binding protein A10b
chr20_+_16750177 0.44 ENSDART00000185357
calm1b
calmodulin 1b
chr4_+_61171310 0.43 ENSDART00000141738
si:dkey-9p20.18
si:dkey-9p20.18
chr25_-_4146947 0.42 ENSDART00000129268
fads2
fatty acid desaturase 2
chr2_-_2937225 0.42 ENSDART00000168132
si:ch1073-82l19.1
si:ch1073-82l19.1
chr1_+_49568335 0.41 ENSDART00000142957
col17a1a
collagen, type XVII, alpha 1a
chr9_-_22831836 0.40 ENSDART00000142585
neb
nebulin
chr10_+_8091144 0.39 ENSDART00000143848
ENSDART00000075485
sub1a
SUB1 homolog, transcriptional regulator a
chr24_-_20369604 0.38 ENSDART00000143174
dlec1
deleted in lung and esophageal cancer 1
chr19_-_30404096 0.37 ENSDART00000103475
agr2
anterior gradient 2
chr17_-_29771639 0.34 ENSDART00000086201
ush2a
Usher syndrome 2A (autosomal recessive, mild)
chr4_-_38033800 0.33 ENSDART00000159662
si:dkeyp-82b4.4
si:dkeyp-82b4.4
chr20_-_2134620 0.31 ENSDART00000064375
tmem244
transmembrane protein 244
chr10_-_15672862 0.31 ENSDART00000109231
mamdc2b
MAM domain containing 2b
chr18_-_39473055 0.31 ENSDART00000122930
scg3
secretogranin III
chr2_+_55982940 0.31 ENSDART00000097753
ENSDART00000097751
nmrk2
nicotinamide riboside kinase 2
chr23_-_20100436 0.30 ENSDART00000143445
si:dkey-32e6.6
si:dkey-32e6.6
chr10_+_8091690 0.29 ENSDART00000189915
sub1a
SUB1 homolog, transcriptional regulator a
chr24_-_21819010 0.28 ENSDART00000091096
CR352265.1

chr2_-_8017579 0.28 ENSDART00000040209
ephb3a
eph receptor B3a
chr3_-_15081874 0.28 ENSDART00000192532
nme4
NME/NM23 nucleoside diphosphate kinase 4
chr23_-_45504991 0.27 ENSDART00000148761
col24a1
collagen type XXIV alpha 1
chr7_-_22132265 0.27 ENSDART00000125284
ENSDART00000112978
nlgn2a
neuroligin 2a
chr5_-_67629263 0.26 ENSDART00000133753
zbtb20
zinc finger and BTB domain containing 20
chr4_-_64709908 0.26 ENSDART00000161032
si:dkey-9i5.2
si:dkey-9i5.2
chr24_-_20369760 0.26 ENSDART00000185585
dlec1
deleted in lung and esophageal cancer 1
chr20_+_10545514 0.26 ENSDART00000153667
serpina1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr19_-_30403922 0.26 ENSDART00000181841
agr2
anterior gradient 2
chr20_+_10539293 0.25 ENSDART00000182265
serpina1l
serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1, like
chr2_-_1364678 0.25 ENSDART00000011919
ENSDART00000164674
ss18
synovial sarcoma translocation, chromosome 18 (H. sapiens)
chr22_-_22416337 0.24 ENSDART00000142947
ENSDART00000089569
camsap2a
calmodulin regulated spectrin-associated protein family, member 2a
chr17_-_7496341 0.22 ENSDART00000186907
si:ch211-278p9.3
si:ch211-278p9.3
chr7_+_57109214 0.21 ENSDART00000135068
ENSDART00000098412
enosf1
enolase superfamily member 1
chr12_-_36521947 0.21 ENSDART00000152946
unc13d
unc-13 homolog D (C. elegans)
chr17_+_52822831 0.20 ENSDART00000193368
meis2a
Meis homeobox 2a
chr17_+_37645633 0.19 ENSDART00000085500
tmem229b
transmembrane protein 229B
chr13_-_8888334 0.19 ENSDART00000059881
plekhh2
pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
chr22_+_39058269 0.19 ENSDART00000113362
ip6k1
inositol hexakisphosphate kinase 1
chr4_-_6416414 0.18 ENSDART00000191136
MDFIC
si:ch73-156e19.1
chr12_+_35654749 0.18 ENSDART00000169889
ENSDART00000167873
baiap2b
BAI1-associated protein 2b
chr21_+_5257018 0.17 ENSDART00000183100
ENSDART00000191525
loxhd1a
lipoxygenase homology domains 1a
chr23_+_21278948 0.17 ENSDART00000156701
ENSDART00000033970
ubr4
ubiquitin protein ligase E3 component n-recognin 4
chr7_+_57108823 0.16 ENSDART00000184943
ENSDART00000055956
enosf1
enolase superfamily member 1
chr6_+_39184236 0.16 ENSDART00000156187
tac3b
tachykinin 3b
chr12_+_22607761 0.16 ENSDART00000153112
si:dkey-219e21.2
si:dkey-219e21.2
chr4_-_6416155 0.15 ENSDART00000110535
MDFIC
si:ch73-156e19.1
chr2_+_30969029 0.15 ENSDART00000085242
lpin2
lipin 2
chr7_-_28647959 0.15 ENSDART00000150148
slc7a6
solute carrier family 7 (amino acid transporter light chain, y+L system), member 6
chr15_+_22722684 0.15 ENSDART00000156760
grik4
glutamate receptor, ionotropic, kainate 4
chr13_-_32577386 0.14 ENSDART00000016535
kcns3a
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3a
chr20_-_20410029 0.13 ENSDART00000192177
ENSDART00000063483
prkchb
protein kinase C, eta, b
chr1_-_56363108 0.13 ENSDART00000021878
gcgrb
glucagon receptor b
chr8_-_34052019 0.13 ENSDART00000040126
ENSDART00000159208
ENSDART00000048994
ENSDART00000098822
pbx3b
pre-B-cell leukemia homeobox 3b
chr16_+_21426524 0.13 ENSDART00000182869
gsdmeb
gasdermin Eb
chr9_-_24242592 0.13 ENSDART00000039399
cavin2a
caveolae associated protein 2a
chr8_-_53108207 0.13 ENSDART00000111023
b3galt4
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
chr6_-_35401282 0.13 ENSDART00000127612
rgs5a
regulator of G protein signaling 5a
chr19_+_30388186 0.13 ENSDART00000103474
tspan13b
tetraspanin 13b
chr8_+_44722140 0.12 ENSDART00000163381
elmod3
ELMO/CED-12 domain containing 3
chr1_-_22757145 0.12 ENSDART00000134719
prom1b
prominin 1 b
chr8_-_31053872 0.12 ENSDART00000109885
snrnp200
small nuclear ribonucleoprotein 200 (U5)
chr3_-_37681824 0.11 ENSDART00000185858
gpatch8
G patch domain containing 8
chr25_-_30394746 0.11 ENSDART00000185346
si:ch211-93f2.1
si:ch211-93f2.1
chr16_+_16849220 0.11 ENSDART00000047409
ENSDART00000142155
myh14
myosin, heavy chain 14, non-muscle
chr20_+_2134816 0.11 ENSDART00000039249
l3mbtl3
l(3)mbt-like 3 (Drosophila)
chr9_-_34296406 0.10 ENSDART00000125451
ildr2
immunoglobulin-like domain containing receptor 2
chr22_-_11438627 0.10 ENSDART00000007649
mid1ip1b
MID1 interacting protein 1b
chr1_+_35194454 0.10 ENSDART00000165389
sc:d189
sc:d189
chr8_+_53423408 0.10 ENSDART00000164792
cacna1db
calcium channel, voltage-dependent, L type, alpha 1D subunit, b
chr14_-_32503363 0.10 ENSDART00000034883
mcf2a
MCF.2 cell line derived transforming sequence a
chr17_+_52822422 0.10 ENSDART00000158273
ENSDART00000161414
meis2a
Meis homeobox 2a
chr16_+_14029283 0.09 ENSDART00000146165
ENSDART00000132075
rusc1
RUN and SH3 domain containing 1
chr4_+_31450683 0.09 ENSDART00000169303
znf996
zinc finger protein 996
chr18_-_2433011 0.09 ENSDART00000181922
ENSDART00000193276
CR769778.1

chr18_-_43880020 0.08 ENSDART00000185638
ddx6
DEAD (Asp-Glu-Ala-Asp) box helicase 6
chr15_-_14469704 0.08 ENSDART00000185077
numbl
numb homolog (Drosophila)-like
chr7_-_24472991 0.08 ENSDART00000121684
nat8l
N-acetyltransferase 8-like
chr3_-_34599662 0.08 ENSDART00000055259
nmrk1
nicotinamide riboside kinase 1
chr13_+_4888351 0.08 ENSDART00000145940
micu1
mitochondrial calcium uptake 1
chr11_-_270210 0.08 ENSDART00000005217
ENSDART00000172779
alas1
aminolevulinate, delta-, synthase 1
chr17_+_5976683 0.07 ENSDART00000110276
zgc:194275
zgc:194275
chr7_+_31051603 0.07 ENSDART00000108721
tjp1a
tight junction protein 1a
chr17_-_22048233 0.07 ENSDART00000155203
ttbk1b
tau tubulin kinase 1b
chr4_+_47385355 0.06 ENSDART00000163413
znf1122
zinc finger protein 1122
chr18_+_40462445 0.06 ENSDART00000087645
ugt5c2
UDP glucuronosyltransferase 5 family, polypeptide C2
chr12_-_2518178 0.06 ENSDART00000128677
ENSDART00000086510
mapk8b
mitogen-activated protein kinase 8b
chr2_-_59285085 0.06 ENSDART00000131880
ftr34
finTRIM family, member 34
chr11_+_24251141 0.06 ENSDART00000182684
pnp4a
purine nucleoside phosphorylase 4a
chr6_+_28141135 0.06 ENSDART00000113405
ENSDART00000179795
inpp5d
inositol polyphosphate-5-phosphatase D
chr3_-_19561058 0.05 ENSDART00000079323
zgc:163079
zgc:163079
chr6_-_13114406 0.05 ENSDART00000188015
zgc:194469
zgc:194469
chr20_+_25581627 0.05 ENSDART00000030229
cyp2p9
cytochrome P450, family 2, subfamily P, polypeptide 9
chr24_+_25692802 0.05 ENSDART00000190493
camk2n2
calcium/calmodulin-dependent protein kinase II inhibitor 2
chr20_-_33976305 0.05 ENSDART00000111022
sele
selectin E
chr17_+_30546579 0.05 ENSDART00000154385
nhsl1a
NHS-like 1a
chr5_+_35502290 0.05 ENSDART00000191222
CR762390.1

chr13_-_15865335 0.05 ENSDART00000135186
si:ch211-57f7.7
si:ch211-57f7.7
chr20_+_34320635 0.05 ENSDART00000153207
ivns1abpa
influenza virus NS1A binding protein a
chr22_+_11857356 0.05 ENSDART00000179540
mras
muscle RAS oncogene homolog
chr13_+_18371208 0.04 ENSDART00000138172
ccar1
cell division cycle and apoptosis regulator 1
chr12_-_37941733 0.04 ENSDART00000130167
CABZ01046949.1

chr8_-_4031121 0.04 ENSDART00000169474
ENSDART00000163754
mtmr3
myotubularin related protein 3
chr17_-_31308658 0.04 ENSDART00000124505
bahd1
bromo adjacent homology domain containing 1
chr16_-_9453591 0.03 ENSDART00000126154
prpf3
PRP3 pre-mRNA processing factor 3 homolog (yeast)
chr4_-_51460013 0.03 ENSDART00000193382
CR628395.1

chr9_+_35860975 0.03 ENSDART00000134447
rcan1a
regulator of calcineurin 1a
chr13_+_28761998 0.03 ENSDART00000146581
prom2
prominin 2
chr7_+_23292133 0.03 ENSDART00000134489
htr2cl1
5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like 1
chr17_+_38262408 0.03 ENSDART00000017493
nkx2.1
NK2 homeobox 1
chr4_-_46648979 0.02 ENSDART00000162101
BX927193.2

chr8_-_39822917 0.02 ENSDART00000067843
zgc:162025
zgc:162025
chr21_-_2707768 0.02 ENSDART00000165384
CABZ01101739.1

chr18_+_41560822 0.02 ENSDART00000158503
baz1b
bromodomain adjacent to zinc finger domain, 1B
chr3_+_33918510 0.02 ENSDART00000055248
alkbh7
alkB homolog 7
chr21_+_39336285 0.02 ENSDART00000139677
si:ch211-274p24.4
si:ch211-274p24.4
chr6_-_21873266 0.01 ENSDART00000151658
ENSDART00000151152
ENSDART00000151179
si:dkey-19e4.5
si:dkey-19e4.5
chr3_+_40407352 0.01 ENSDART00000155112
tnrc18
trinucleotide repeat containing 18
chr1_-_22756898 0.01 ENSDART00000158915
prom1b
prominin 1 b
chr16_-_11928774 0.01 ENSDART00000183229
cd4-1
CD4-1 molecule
chr12_+_27127139 0.01 ENSDART00000025966
hoxb6b
homeobox B6b
chr2_-_59285407 0.01 ENSDART00000181616
ftr34
finTRIM family, member 34
chr25_-_31118923 0.01 ENSDART00000009126
ENSDART00000188286
kras
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
chr6_+_28140816 0.01 ENSDART00000137907
inpp5d
inositol polyphosphate-5-phosphatase D
chr15_-_34892664 0.00 ENSDART00000153787
ENSDART00000099721
rnf183
ring finger protein 183
chr11_-_13341483 0.00 ENSDART00000164978
mast3b
microtubule associated serine/threonine kinase 3b
chr11_+_38332419 0.00 ENSDART00000005864
CDK18
si:dkey-166c18.1
chr5_+_28398449 0.00 ENSDART00000165292
nsmfb
NMDA receptor synaptonuclear signaling and neuronal migration factor b
chr6_-_49673476 0.00 ENSDART00000112226
apcdd1l
adenomatosis polyposis coli down-regulated 1-like

Network of associatons between targets according to the STRING database.

First level regulatory network of tlx1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0034650 cortisol metabolic process(GO:0034650)
0.1 0.9 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.1 0.7 GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.1 0.4 GO:0071691 cardiac muscle thin filament assembly(GO:0071691)
0.1 0.6 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.1 0.5 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.1 0.5 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.0 0.3 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) collagen-activated signaling pathway(GO:0038065)
0.0 0.2 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.0 0.3 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.3 GO:0010996 response to auditory stimulus(GO:0010996)
0.0 0.3 GO:0097105 presynaptic membrane organization(GO:0097090) postsynaptic membrane assembly(GO:0097104) presynaptic membrane assembly(GO:0097105)
0.0 0.2 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.0 0.1 GO:0000393 spliceosomal conformational changes to generate catalytic conformation(GO:0000393)
0.0 0.3 GO:0006228 UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)
0.0 0.3 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 0.2 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026) negative regulation of microtubule polymerization or depolymerization(GO:0031111)
0.0 0.1 GO:0051561 positive regulation of mitochondrial calcium ion concentration(GO:0051561)
0.0 0.4 GO:0050654 chondroitin sulfate proteoglycan metabolic process(GO:0050654)
0.0 0.1 GO:0034063 stress granule assembly(GO:0034063)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0005592 collagen type XI trimer(GO:0005592)
0.1 0.3 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.1 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 0.4 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 0.2 GO:0071914 prominosome(GO:0071914)
0.0 0.2 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.3 GO:0030667 secretory granule membrane(GO:0030667)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 GO:1903924 estradiol binding(GO:1903924)
0.1 0.3 GO:0070052 collagen V binding(GO:0070052)
0.1 0.4 GO:0050262 ribosylnicotinamide kinase activity(GO:0050262)
0.0 0.1 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.8 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0033764)
0.0 0.1 GO:0016519 gastric inhibitory peptide receptor activity(GO:0016519)
0.0 0.1 GO:0016748 succinyltransferase activity(GO:0016748)
0.0 0.2 GO:0004096 catalase activity(GO:0004096)
0.0 0.5 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.0 0.4 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.2 GO:0030507 spectrin binding(GO:0030507)
0.0 0.5 GO:0019003 GDP binding(GO:0019003)
0.0 0.4 GO:0005518 collagen binding(GO:0005518)
0.0 0.2 GO:0000828 inositol hexakisphosphate kinase activity(GO:0000828)
0.0 1.0 GO:0008080 N-acetyltransferase activity(GO:0008080)
0.0 0.3 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.2 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 NABA PROTEOGLYCANS Genes encoding proteoglycans

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.4 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.3 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.4 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.1 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.1 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors