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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for tp53

Z-value: 1.02

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Transcription factors associated with tp53

Gene Symbol Gene ID Gene Info
tp53
ENSDARG00000035559 tumor protein p53
tp53
ENSDARG00000115148 tumor protein p53

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tp53dr11_v1_chr5_+_24087035_240870350.928.6e-08Click!

Activity profile of tp53 motif

Sorted Z-values of tp53 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_+_22132896 5.52 ENSDART00000138274
ccng1
cyclin G1
chr5_+_57924611 4.57 ENSDART00000050949
btg4
B-cell translocation gene 4
chr25_+_36292465 3.74 ENSDART00000152649
bmb
brambleberry
chr19_+_2835240 2.85 ENSDART00000190838
CDCP1
CUB domain containing protein 1
chr16_+_20496691 2.74 ENSDART00000182737
ENSDART00000078984
cpvl
carboxypeptidase, vitellogenic-like
chr6_-_7109063 2.56 ENSDART00000148548
nhej1
nonhomologous end-joining factor 1
chr21_-_19919020 2.27 ENSDART00000147396
ppp1r3b
protein phosphatase 1, regulatory subunit 3B
chr16_-_34195002 2.26 ENSDART00000054026
rcc1
regulator of chromosome condensation 1
chr5_+_27404946 2.20 ENSDART00000121886
ENSDART00000005025
hdr
hematopoietic death receptor
chr5_-_1999417 2.07 ENSDART00000155437
ENSDART00000145781
si:ch211-160e1.5
si:ch211-160e1.5
chr17_+_25849332 2.06 ENSDART00000191994
acss1
acyl-CoA synthetase short chain family member 1
chr7_+_38809241 1.99 ENSDART00000190979
harbi1
harbinger transposase derived 1
chr5_+_29831235 1.97 ENSDART00000109660
f11r.1
F11 receptor, tandem duplicate 1
chr3_+_24595922 1.96 ENSDART00000169405
si:dkey-68o6.5
si:dkey-68o6.5
chr25_-_17910714 1.80 ENSDART00000191586
arntl1a
aryl hydrocarbon receptor nuclear translocator-like 1a
chr19_-_25114701 1.75 ENSDART00000149035
ptp4a3
protein tyrosine phosphatase type IVA, member 3
chr18_+_27515640 1.74 ENSDART00000181593
tp53i11b
tumor protein p53 inducible protein 11b
chr19_-_27570333 1.71 ENSDART00000146562
ENSDART00000179060
si:dkeyp-46h3.5
si:dkeyp-46h3.8
si:dkeyp-46h3.5
si:dkeyp-46h3.8
chr6_+_43450221 1.65 ENSDART00000075521
zgc:113054
zgc:113054
chr19_-_25149034 1.63 ENSDART00000148432
ENSDART00000175266
ptp4a3
protein tyrosine phosphatase type IVA, member 3
chr16_-_42175617 1.57 ENSDART00000084715
alkbh8
alkB homolog 8, tRNA methyltransferase
chr4_-_858434 1.57 ENSDART00000006961
sobpb
sine oculis binding protein homolog (Drosophila) b
chr18_+_14619544 1.53 ENSDART00000010821
utp4
UTP4, small subunit processome component
chr15_+_28175638 1.53 ENSDART00000037119
slc46a1
solute carrier family 46 (folate transporter), member 1
chr13_+_22712406 1.51 ENSDART00000132847
si:ch211-134m17.9
si:ch211-134m17.9
chr5_-_37959874 1.45 ENSDART00000031719
mpzl2b
myelin protein zero-like 2b
chr5_+_66170479 1.37 ENSDART00000172117
gldc
glycine dehydrogenase (decarboxylating)
chr12_-_33789006 1.37 ENSDART00000034550
llgl2
lethal giant larvae homolog 2 (Drosophila)
chr23_-_31428763 1.29 ENSDART00000053545
zgc:153284
zgc:153284
chr9_+_50110763 1.28 ENSDART00000162990
cobll1b
cordon-bleu WH2 repeat protein-like 1b
chr22_+_14836040 1.26 ENSDART00000180951
gtpbp1l
GTP binding protein 1, like
chr12_-_33789218 1.26 ENSDART00000193258
llgl2
lethal giant larvae homolog 2 (Drosophila)
chr15_-_25094026 1.25 ENSDART00000129154
exo5
exonuclease 5
chr6_+_13046720 1.23 ENSDART00000165896
casp8
caspase 8, apoptosis-related cysteine peptidase
chr9_+_41474623 1.23 ENSDART00000137187
nemp2
nuclear envelope integral membrane protein 2
chr25_+_19095231 1.22 ENSDART00000154066
isg20
interferon stimulated exonuclease gene
chr15_+_17343319 1.21 ENSDART00000018461
vmp1
vacuole membrane protein 1
chr5_-_19963537 1.17 ENSDART00000148146
si:dkey-234h16.7
si:dkey-234h16.7
chr1_+_45969240 1.17 ENSDART00000042086
arhgef7b
Rho guanine nucleotide exchange factor (GEF) 7b
chr13_-_9300299 1.16 ENSDART00000144142
HTRA2 (1 of many)
si:dkey-33c12.12
chr5_+_24089334 1.16 ENSDART00000183748
tp53
tumor protein p53
chr18_+_35861930 1.14 ENSDART00000185223
ppp1r13l
protein phosphatase 1, regulatory subunit 13 like
chr25_+_19522954 1.13 ENSDART00000006512
ENSDART00000184279
sh3gl3b
SH3-domain GRB2-like 3b
chr11_-_27057572 1.12 ENSDART00000043091
iqsec1b
IQ motif and Sec7 domain 1b
chr7_+_26049818 1.10 ENSDART00000173611
si:dkey-6n21.12
si:dkey-6n21.12
chr15_-_25093680 1.10 ENSDART00000062695
exo5
exonuclease 5
chr5_+_8196264 1.08 ENSDART00000174564
ENSDART00000161261
lmbrd2a
LMBR1 domain containing 2a
chr9_-_18735256 1.04 ENSDART00000143165
tsc22d1
TSC22 domain family, member 1
chr8_-_30338872 1.04 ENSDART00000137583
dock8
dedicator of cytokinesis 8
chr17_-_27200025 1.03 ENSDART00000192699
asap3
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
chr20_-_40766387 1.03 ENSDART00000061173
hsdl1
hydroxysteroid dehydrogenase like 1
chr4_+_23127104 1.02 ENSDART00000139543
mdm2
MDM2 oncogene, E3 ubiquitin protein ligase
chr23_+_4483083 1.00 ENSDART00000092389
nup210
nucleoporin 210
chr25_+_26441054 0.96 ENSDART00000158607
dapk2b
death-associated protein kinase 2b
chr5_-_33039670 0.93 ENSDART00000141361
glipr2
GLI pathogenesis-related 2
chr4_-_13931508 0.93 ENSDART00000067174
zcrb1
zinc finger CCHC-type and RNA binding motif 1
chr6_-_19270484 0.92 ENSDART00000186894
ENSDART00000188709
zgc:174863
zgc:174863
chr16_+_53387085 0.91 ENSDART00000154223
ENSDART00000101404
kif13a
kinesin family member 13A
chr14_+_14027427 0.91 ENSDART00000183204
rraga
Ras-related GTP binding A
chr4_+_25607743 0.90 ENSDART00000028297
acot14
acyl-CoA thioesterase 14
chr16_+_38201840 0.89 ENSDART00000044971
myo1eb
myosin IE, b
chr13_-_36049008 0.88 ENSDART00000189978
lgmn
legumain
chr8_+_23639124 0.85 ENSDART00000083108
nt5dc2
5'-nucleotidase domain containing 2
chr8_+_15277874 0.84 ENSDART00000146965
dnttip2
deoxynucleotidyltransferase, terminal, interacting protein 2
chr14_+_49152341 0.84 ENSDART00000084114
nsd1a
nuclear receptor binding SET domain protein 1a
chr4_+_23127284 0.83 ENSDART00000122675
mdm2
MDM2 oncogene, E3 ubiquitin protein ligase
chr21_-_41065369 0.82 ENSDART00000143749
larsb
leucyl-tRNA synthetase b
chr6_-_19313925 0.82 ENSDART00000160311
sumo2a
small ubiquitin-like modifier 2a
chr11_+_42641404 0.82 ENSDART00000172641
ENSDART00000169938
il17rd
interleukin 17 receptor D
chr15_-_43238220 0.80 ENSDART00000027019
wdfy1
WD repeat and FYVE domain containing 1
chr17_-_40879108 0.79 ENSDART00000010362
supt7l
SPT7-like STAGA complex gamma subunit
chr25_+_28158352 0.77 ENSDART00000151854
cadps2
Ca++-dependent secretion activator 2
chr4_-_13931293 0.76 ENSDART00000067172
zcrb1
zinc finger CCHC-type and RNA binding motif 1
chr2_-_37743834 0.74 ENSDART00000088040
ENSDART00000191057
myo9b
myosin IXb
chr7_+_54260004 0.74 ENSDART00000171909
pacsin3
protein kinase C and casein kinase substrate in neurons 3
chr3_-_50147160 0.73 ENSDART00000191341
btr02
bloodthirsty-related gene family, member 2
chr13_-_25745089 0.72 ENSDART00000189333
ENSDART00000147420
sgpl1
sphingosine-1-phosphate lyase 1
chr20_+_42537768 0.70 ENSDART00000134066
ENSDART00000153434
si:dkeyp-93d12.1
si:dkeyp-93d12.1
chr13_+_24755049 0.70 ENSDART00000134102
col17a1b
collagen, type XVII, alpha 1b
chr4_+_13931578 0.70 ENSDART00000142466
pphln1
periphilin 1
chr7_-_36358303 0.67 ENSDART00000130028
fto
fat mass and obesity associated
chr20_-_40367493 0.67 ENSDART00000075096
smpdl3a
sphingomyelin phosphodiesterase, acid-like 3A
chr5_-_62925282 0.66 ENSDART00000188048
specc1
sperm antigen with calponin homology and coiled-coil domains 1
chr4_-_16833518 0.65 ENSDART00000179867
ldhba
lactate dehydrogenase Ba
chr4_+_23126558 0.63 ENSDART00000162859
mdm2
MDM2 oncogene, E3 ubiquitin protein ligase
chr10_+_8554929 0.60 ENSDART00000190849
tbc1d10ab
TBC1 domain family, member 10Ab
chr22_+_1947494 0.59 ENSDART00000159121
si:dkey-15h8.15
si:dkey-15h8.15
chr25_-_27735290 0.59 ENSDART00000140663
zgc:153935
zgc:153935
chr4_+_13931733 0.59 ENSDART00000141742
ENSDART00000067175
pphln1
periphilin 1
chr11_+_38429319 0.59 ENSDART00000029157
mfsd4aa
major facilitator superfamily domain containing 4Aa
chr7_-_36358735 0.56 ENSDART00000188392
fto
fat mass and obesity associated
chr7_-_17816921 0.56 ENSDART00000149821
ecsit
ECSIT signalling integrator
chr4_+_26628822 0.55 ENSDART00000191030
ENSDART00000186113
ENSDART00000186764
ENSDART00000165158
iqsec3a
IQ motif and Sec7 domain 3a
chr2_+_37837249 0.51 ENSDART00000113337
parp2
poly (ADP-ribose) polymerase 2
chr19_-_32944050 0.51 ENSDART00000137611
azin1b
antizyme inhibitor 1b
chr23_-_5783421 0.49 ENSDART00000131521
ENSDART00000019455
csrp1a
cysteine and glycine-rich protein 1a
chr9_-_12493628 0.48 ENSDART00000180832
igf2bp2a
insulin-like growth factor 2 mRNA binding protein 2a
chr7_-_26049282 0.47 ENSDART00000136389
ENSDART00000101124
rnaseka
ribonuclease, RNase K a
chr14_+_29941266 0.47 ENSDART00000112757
fam149a
family with sequence similarity 149 member A
chr19_+_3215466 0.46 ENSDART00000181288
zgc:86598
zgc:86598
chr12_+_19320657 0.45 ENSDART00000100075
ENSDART00000066389
tmem184ba
transmembrane protein 184ba
chr12_+_22576404 0.45 ENSDART00000172053
capgb
capping protein (actin filament), gelsolin-like b
chr8_-_13362757 0.44 ENSDART00000188608
ccdc124
coiled-coil domain containing 124
chr4_-_8779141 0.44 ENSDART00000182314
ENSDART00000172376
ttll12
tubulin tyrosine ligase-like family, member 12
chr2_+_7557912 0.43 ENSDART00000160053
ripk2
receptor-interacting serine-threonine kinase 2
chr16_-_18960613 0.43 ENSDART00000183197
fhod3b
formin homology 2 domain containing 3b
chr12_-_5505205 0.42 ENSDART00000092319
abi3b
ABI family, member 3b
chr21_+_44857293 0.41 ENSDART00000134365
ENSDART00000168217
ENSDART00000065083
fstl4
follistatin-like 4
chr5_+_43965078 0.40 ENSDART00000113502
ENSDART00000187143
TMEM8B
si:dkey-84j12.1
chr22_+_2632961 0.39 ENSDART00000106278
znf1173
zinc finger protein 1173
chr6_-_43283122 0.38 ENSDART00000186022
frmd4ba
FERM domain containing 4Ba
chr9_-_3958533 0.37 ENSDART00000129091
ubr3
ubiquitin protein ligase E3 component n-recognin 3
chr19_+_4142529 0.37 ENSDART00000162913
si:dkey-218f9.10
si:dkey-218f9.10
chr7_-_2430286 0.37 ENSDART00000129312
zgc:66473
zgc:66473
chr17_+_40879331 0.37 ENSDART00000046003
slc4a1ap
solute carrier family 4 (anion exchanger), member 1, adaptor protein
chr12_+_48784731 0.37 ENSDART00000158348
zmiz1b
zinc finger, MIZ-type containing 1b
chr1_-_18592068 0.36 ENSDART00000082063
fam114a1
family with sequence similarity 114, member A1
chr24_-_15159658 0.35 ENSDART00000142473
rttn
rotatin
chr9_+_51882534 0.34 ENSDART00000165493
CABZ01079550.1

chr3_+_35812040 0.33 ENSDART00000075903
ENSDART00000147712
crlf3
cytokine receptor-like factor 3
chr3_-_50118140 0.33 ENSDART00000131913
hgs
hepatocyte growth factor-regulated tyrosine kinase substrate
chr12_+_6098713 0.33 ENSDART00000139054
sgms1
sphingomyelin synthase 1
chr8_+_7801060 0.33 ENSDART00000161618
tfe3a
transcription factor binding to IGHM enhancer 3a
chr20_-_7176809 0.32 ENSDART00000012247
ENSDART00000125019
dhcr24
24-dehydrocholesterol reductase
chr18_+_44769027 0.32 ENSDART00000145190
ilvbl
ilvB (bacterial acetolactate synthase)-like
chr9_+_29671553 0.31 ENSDART00000015377
rnaseh2b
ribonuclease H2, subunit B
chr24_-_30862168 0.31 ENSDART00000168540
ptbp2a
polypyrimidine tract binding protein 2a
chr16_-_40459104 0.27 ENSDART00000032389
plekhf2
pleckstrin homology domain containing, family F (with FYVE domain) member 2
chr7_-_2292403 0.27 ENSDART00000075856
zgc:66473
zgc:66473
chr13_-_25774183 0.26 ENSDART00000046981
pdlim1
PDZ and LIM domain 1 (elfin)
chr17_-_22137199 0.26 ENSDART00000089689
mrps5
mitochondrial ribosomal protein S5
chr11_-_13618412 0.25 ENSDART00000137289
sid1
secreted immunoglobulin domain 1
chr1_+_6817292 0.25 ENSDART00000145822
ENSDART00000092118
erbb4a
erb-b2 receptor tyrosine kinase 4a
chr23_-_1017428 0.25 ENSDART00000110588
ENSDART00000183158
cdh26.1
cadherin 26, tandem duplicate 1
chr17_-_10838434 0.25 ENSDART00000064597
lgals3b
lectin, galactoside binding soluble 3b
chr4_+_9450415 0.25 ENSDART00000189690
tmtc1
transmembrane and tetratricopeptide repeat containing 1
chr22_-_6404807 0.24 ENSDART00000149399
ENSDART00000063420
si:rp71-1i20.2
si:rp71-1i20.2
chr7_-_20464133 0.23 ENSDART00000078192
cnpy4
canopy4
chr20_-_45708962 0.23 ENSDART00000124283
gpcpd1
glycerophosphocholine phosphodiesterase 1
chr2_-_24068848 0.22 ENSDART00000145526
slc12a7a
solute carrier family 12 (potassium/chloride transporter), member 7a
chr9_+_56103173 0.21 ENSDART00000172063
edar
ectodysplasin A receptor
chr18_+_2554666 0.20 ENSDART00000167218
p2ry2.1
purinergic receptor P2Y2, tandem duplicate 1
chr8_-_4694458 0.20 ENSDART00000019828
zgc:63587
zgc:63587
chr16_+_35595312 0.20 ENSDART00000170438
si:ch211-1i11.3
si:ch211-1i11.3
chr16_-_30903930 0.18 ENSDART00000143996
dennd3b
DENN/MADD domain containing 3b
chr13_+_31144305 0.18 ENSDART00000189602
CR931802.4

chr11_+_14295011 0.17 ENSDART00000060226
si:ch211-262i1.4
si:ch211-262i1.4
chr18_-_22717565 0.17 ENSDART00000142185
ENSDART00000059945
si:ch73-113g13.1
si:ch73-113g13.1
chr3_+_30922947 0.17 ENSDART00000184060
cldni
claudin i
chr2_-_27900518 0.15 ENSDART00000109561
ENSDART00000077720
zgc:163121
zgc:163121
chr12_+_34768106 0.15 ENSDART00000126420
ENSDART00000174433
slc38a10
solute carrier family 38, member 10
chr21_+_25688388 0.14 ENSDART00000125709
bicdl2
bicaudal-D-related protein 2
chr16_-_9423735 0.14 ENSDART00000185645
ccr8.1
chemokine (C-C motif) receptor 8.1
chr25_-_35147698 0.12 ENSDART00000121963
zgc:165555
zgc:165555
chr18_-_31916845 0.12 ENSDART00000165908
olfcs2
olfactory receptor C family, s2
chr10_+_40722256 0.11 ENSDART00000099154
taar19q
trace amine associated receptor 19q
chr4_+_34418211 0.11 ENSDART00000160070
si:ch211-246b8.2
si:ch211-246b8.2
chr22_-_15693085 0.11 ENSDART00000141861
si:ch1073-396h14.1
si:ch1073-396h14.1
chr4_-_71554068 0.10 ENSDART00000167414
si:dkey-27n6.1
si:dkey-27n6.1
chr20_-_7133546 0.10 ENSDART00000160910
si:ch211-121a2.4
si:ch211-121a2.4
chr3_-_41795917 0.10 ENSDART00000182662
grifin
galectin-related inter-fiber protein
chr17_-_2386569 0.09 ENSDART00000121614
PLCB2
phospholipase C beta 2
chr3_-_22359119 0.09 ENSDART00000168184
ifnphi2
interferon phi 2
chr4_-_44508975 0.09 ENSDART00000180528
si:dkeyp-100h4.1
si:dkeyp-100h4.1
chr9_+_23511913 0.09 ENSDART00000137759
cntnap5a
contactin associated protein-like 5a
chr22_+_8365905 0.08 ENSDART00000105945
si:dkey-19a16.11
si:dkey-19a16.11
chr13_+_21600946 0.08 ENSDART00000144045
sh2d4ba
SH2 domain containing 4Ba
chr7_+_24520518 0.08 ENSDART00000173604
btr09
bloodthirsty-related gene family, member 9
chr4_-_44509477 0.08 ENSDART00000102949
ENSDART00000135262
si:dkeyp-100h4.1
si:dkeyp-100h4.1
chr23_-_1017605 0.08 ENSDART00000138290
cdh26.1
cadherin 26, tandem duplicate 1
chr7_+_4194055 0.08 ENSDART00000105073
si:dkey-28d5.14
si:dkey-28d5.14
chr4_+_59246094 0.08 ENSDART00000160587
si:dkey-105i14.1
si:dkey-105i14.1
chr22_+_5959984 0.07 ENSDART00000179378
ENSDART00000178985
ENSDART00000174635
BX322587.2

chr4_-_70050522 0.07 ENSDART00000100252
si:ch211-171l17.14
si:ch211-171l17.14
chr3_-_28828569 0.07 ENSDART00000167679
si:ch211-76l23.4
si:ch211-76l23.4
chr5_-_57686487 0.07 ENSDART00000074264
crfb12
cytokine receptor family member B12
chr20_-_38610360 0.06 ENSDART00000168783
ENSDART00000164638
slc30a2
solute carrier family 30 (zinc transporter), member 2
chr20_-_43663494 0.06 ENSDART00000144564
BX470188.1

chr22_+_17203752 0.06 ENSDART00000143376
rab3b
RAB3B, member RAS oncogene family
chr4_+_59245846 0.06 ENSDART00000104921
si:dkey-105i14.1
si:dkey-105i14.1
chr9_+_8929764 0.05 ENSDART00000102562
ankrd10b
ankyrin repeat domain 10b
chr20_-_27225876 0.05 ENSDART00000149204
ENSDART00000149732
si:dkey-85n7.7
si:dkey-85n7.7
chr22_+_9793923 0.05 ENSDART00000063323
si:dkey-102c8.2
si:dkey-102c8.2
chr22_+_9854088 0.05 ENSDART00000122678
BX539307.1

chr19_+_25154066 0.05 ENSDART00000163220
si:ch211-239d6.2
si:ch211-239d6.2
chr1_+_58375871 0.05 ENSDART00000166736
CU914631.1

chr3_-_7940522 0.04 ENSDART00000159710
ENSDART00000167201
trim35-25
tripartite motif containing 35-25
chr6_-_18960105 0.04 ENSDART00000185278
ENSDART00000162968
sept9b
septin 9b
chr11_+_6764207 0.04 ENSDART00000104292
pde4cb
phosphodiesterase 4C, cAMP-specific b
chr13_-_992458 0.04 ENSDART00000114655
BFSP1
beaded filament structural protein 1
chr12_-_16435150 0.04 ENSDART00000086211
pcgf5b
polycomb group ring finger 5b
chr4_-_34455848 0.04 ENSDART00000184208
si:ch211-64i20.3
si:ch211-64i20.3
chr1_-_11596829 0.03 ENSDART00000140725
si:dkey-26i13.7
si:dkey-26i13.7
chr12_+_44610912 0.03 ENSDART00000179030
ENSDART00000178008
FAM196A (1 of many)
family with sequence similarity 196 member A
chr20_+_7398090 0.03 ENSDART00000108649
pcsk9
proprotein convertase subtilisin/kexin type 9
chr4_+_34417798 0.02 ENSDART00000157757
si:ch211-246b8.2
si:ch211-246b8.2
chr24_+_12200260 0.02 ENSDART00000181391
CR855257.2

chr3_-_50146854 0.02 ENSDART00000157047
si:dkey-120c6.5
si:dkey-120c6.5
chr4_-_1914228 0.02 ENSDART00000087835
ano6
anoctamin 6
chr14_+_36231126 0.02 ENSDART00000141766
elovl6
ELOVL fatty acid elongase 6

Network of associatons between targets according to the STRING database.

First level regulatory network of tp53

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.3 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.7 3.7 GO:0000741 karyogamy(GO:0000741) pronuclear fusion(GO:0007344)
0.5 2.2 GO:0036462 TRAIL-activated apoptotic signaling pathway(GO:0036462)
0.5 2.6 GO:0010719 photoreceptor cell morphogenesis(GO:0008594) negative regulation of epithelial to mesenchymal transition(GO:0010719)
0.5 2.5 GO:1904036 negative regulation of epithelial cell apoptotic process(GO:1904036)
0.4 1.2 GO:0042245 RNA repair(GO:0042245)
0.4 1.2 GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism(GO:0043903)
0.4 1.2 GO:0071896 protein localization to adherens junction(GO:0071896)
0.4 1.2 GO:0010525 regulation of transposition, RNA-mediated(GO:0010525) negative regulation of transposition, RNA-mediated(GO:0010526) transposition, RNA-mediated(GO:0032197) positive regulation of neuron apoptotic process(GO:0043525) positive regulation of neuron death(GO:1901216)
0.3 2.1 GO:0006083 acetate metabolic process(GO:0006083) acetyl-CoA biosynthetic process from acetate(GO:0019427)
0.3 1.4 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.3 2.3 GO:1901673 regulation of mitotic spindle assembly(GO:1901673)
0.3 0.9 GO:2000425 regulation of apoptotic cell clearance(GO:2000425)
0.3 1.3 GO:0097355 protein localization to heterochromatin(GO:0097355)
0.2 0.9 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.2 1.1 GO:0035332 positive regulation of hippo signaling(GO:0035332)
0.1 2.0 GO:0050892 intestinal absorption(GO:0050892)
0.1 1.5 GO:0010569 regulation of double-strand break repair via homologous recombination(GO:0010569)
0.1 0.9 GO:0072386 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.1 2.6 GO:0006303 double-strand break repair via nonhomologous end joining(GO:0006303)
0.1 0.5 GO:1902269 polyamine transport(GO:0015846) polyamine transmembrane transport(GO:1902047) regulation of polyamine transmembrane transport(GO:1902267) positive regulation of polyamine transmembrane transport(GO:1902269)
0.1 0.6 GO:0061635 regulation of protein complex stability(GO:0061635)
0.1 0.3 GO:0006549 isoleucine metabolic process(GO:0006549) isoleucine biosynthetic process(GO:0009097)
0.1 0.4 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.1 1.1 GO:0072554 endothelial tube morphogenesis(GO:0061154) blood vessel lumenization(GO:0072554)
0.1 1.6 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.1 0.2 GO:0070255 regulation of mucus secretion(GO:0070255) positive regulation of mucus secretion(GO:0070257)
0.1 0.7 GO:0014028 notochord formation(GO:0014028)
0.1 0.7 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.1 1.2 GO:0044872 lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872)
0.1 0.8 GO:1990504 dense core granule exocytosis(GO:1990504)
0.1 0.3 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.1 1.6 GO:0036297 interstrand cross-link repair(GO:0036297)
0.1 0.3 GO:0048245 eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.0 1.5 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 1.6 GO:0009648 photoperiodism(GO:0009648)
0.0 0.3 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.6 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.8 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 1.7 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 4.6 GO:0008285 negative regulation of cell proliferation(GO:0008285)
0.0 0.1 GO:0055107 Golgi to secretory granule transport(GO:0055107)
0.0 0.8 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.3 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.0 0.4 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 1.2 GO:1904029 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 0.7 GO:0046466 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
0.0 1.1 GO:0071875 adrenergic receptor signaling pathway(GO:0071875)
0.0 0.8 GO:0043966 histone H3 acetylation(GO:0043966)
0.0 0.4 GO:0007257 activation of JUN kinase activity(GO:0007257) positive regulation of JUN kinase activity(GO:0043507)
0.0 0.4 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.9 GO:0099515 vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)
0.0 0.9 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.0 0.1 GO:0061088 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.0 0.4 GO:0051014 actin filament severing(GO:0051014)
0.0 0.2 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 0.7 GO:0007254 JNK cascade(GO:0007254)
0.0 0.2 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.0 0.2 GO:0046475 glycerophospholipid catabolic process(GO:0046475)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.6 GO:0032807 DNA ligase IV complex(GO:0032807)
0.5 1.4 GO:0005960 glycine cleavage complex(GO:0005960)
0.2 0.9 GO:0034448 EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.1 2.3 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 1.8 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.1 0.8 GO:0030914 STAGA complex(GO:0030914)
0.1 0.3 GO:0005948 acetolactate synthase complex(GO:0005948)
0.1 4.0 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 0.3 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.1 1.7 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.1 2.6 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 1.5 GO:0030686 90S preribosome(GO:0030686)
0.0 4.8 GO:0031965 nuclear membrane(GO:0031965)
0.0 1.2 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 0.3 GO:0001772 immunological synapse(GO:0001772)
0.0 1.7 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.3 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.0 2.5 GO:0070160 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 0.9 GO:0031941 filamentous actin(GO:0031941)
0.0 2.0 GO:0030027 lamellipodium(GO:0030027)
0.0 0.9 GO:0005902 microvillus(GO:0005902)
0.0 1.0 GO:0005643 nuclear pore(GO:0005643)
0.0 0.8 GO:0098978 glutamatergic synapse(GO:0098978)
0.0 0.4 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.6 GO:0030496 midbody(GO:0030496)
0.0 0.3 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.3 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 1.2 GO:0016607 nuclear speck(GO:0016607)
0.0 0.9 GO:0005871 kinesin complex(GO:0005871)
0.0 3.0 GO:0005730 nucleolus(GO:0005730)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0045145 single-stranded DNA 5'-3' exodeoxyribonuclease activity(GO:0045145)
0.5 2.7 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.5 1.6 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.3 2.1 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.3 1.2 GO:0035516 oxidative DNA demethylase activity(GO:0035516) DNA-N1-methyladenine dioxygenase activity(GO:0043734) RNA N6-methyladenosine dioxygenase activity(GO:1990931)
0.3 1.5 GO:0005542 folic acid binding(GO:0005542)
0.2 0.7 GO:0008117 sphinganine-1-phosphate aldolase activity(GO:0008117)
0.2 2.6 GO:0045159 myosin II binding(GO:0045159)
0.2 2.3 GO:2001069 glycogen binding(GO:2001069)
0.1 1.4 GO:0016594 glycine binding(GO:0016594)
0.1 0.3 GO:0003984 acetolactate synthase activity(GO:0003984)
0.1 0.7 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.1 0.5 GO:0042978 ornithine decarboxylase activator activity(GO:0042978)
0.1 1.2 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.1 0.2 GO:2001070 starch binding(GO:2001070)
0.1 0.8 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.1 1.3 GO:0003785 actin monomer binding(GO:0003785)
0.1 1.7 GO:0008171 O-methyltransferase activity(GO:0008171)
0.1 0.3 GO:0047493 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.1 0.8 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.1 0.8 GO:0031386 protein tag(GO:0031386)
0.1 0.3 GO:0019865 IgE binding(GO:0019863) immunoglobulin binding(GO:0019865)
0.0 1.2 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.4 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.0 0.7 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 1.3 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.0 0.9 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.0 1.2 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 0.6 GO:0015149 glucose transmembrane transporter activity(GO:0005355) monosaccharide transmembrane transporter activity(GO:0015145) hexose transmembrane transporter activity(GO:0015149)
0.0 0.1 GO:0048030 disaccharide binding(GO:0048030)
0.0 1.6 GO:0000146 microfilament motor activity(GO:0000146)
0.0 0.8 GO:0042805 actinin binding(GO:0042805)
0.0 4.3 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.5 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 1.6 GO:0043566 structure-specific DNA binding(GO:0043566)
0.0 1.2 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.2 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 0.8 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 0.2 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.3 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.0 2.2 GO:0004518 nuclease activity(GO:0004518)
0.0 0.4 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.6 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.2 1.2 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1 6.6 PID P53 REGULATION PATHWAY p53 pathway
0.1 3.4 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.1 2.1 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.1 2.6 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 3.0 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.7 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 0.3 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 0.1 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 0.7 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.4 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 0.8 PID FGF PATHWAY FGF signaling pathway
0.0 0.3 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.5 PID TELOMERASE PATHWAY Regulation of Telomerase

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.1 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.2 2.5 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.2 1.2 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.1 1.5 REACTOME IRON UPTAKE AND TRANSPORT Genes involved in Iron uptake and transport
0.1 0.9 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.1 0.5 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 1.2 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.4 REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES Genes involved in p75NTR recruits signalling complexes
0.0 3.3 REACTOME LATE PHASE OF HIV LIFE CYCLE Genes involved in Late Phase of HIV Life Cycle
0.0 0.9 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 1.0 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.3 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.3 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.1 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine