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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for tp73

Z-value: 0.44

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Transcription factors associated with tp73

Gene Symbol Gene ID Gene Info
tp73
ENSDARG00000017953 tumor protein p73

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tp73dr11_v1_chr8_+_48858132_48858149-0.401.0e-01Click!

Activity profile of tp73 motif

Sorted Z-values of tp73 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_40837539 1.04 ENSDART00000188279
si:dkey-3h3.3
si:dkey-3h3.3
chr14_+_22132896 0.94 ENSDART00000138274
ccng1
cyclin G1
chr19_+_6938289 0.66 ENSDART00000139122
ENSDART00000178832
flot1b
flotillin 1b
chr2_+_44528255 0.58 ENSDART00000193834
pask
PAS domain containing serine/threonine kinase
chr20_-_164300 0.54 ENSDART00000183354
si:ch211-241j12.3
si:ch211-241j12.3
chr12_+_5358409 0.51 ENSDART00000152632
plce1
phospholipase C, epsilon 1
chr12_-_3077395 0.51 ENSDART00000002867
ENSDART00000126315
rfng
RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr22_+_24318131 0.48 ENSDART00000187360
ENSDART00000165618
ccdc50
coiled-coil domain containing 50
chr16_-_21489514 0.47 ENSDART00000149525
ENSDART00000148517
ENSDART00000146914
ENSDART00000186493
ENSDART00000193081
ENSDART00000186017
mpp6a
membrane protein, palmitoylated 6a (MAGUK p55 subfamily member 6)
chr2_+_37837249 0.41 ENSDART00000113337
parp2
poly (ADP-ribose) polymerase 2
chr11_+_14333441 0.40 ENSDART00000171969
ptbp1b
polypyrimidine tract binding protein 1b
chr23_+_9258531 0.38 ENSDART00000138745
acss2
acyl-CoA synthetase short chain family member 2
chr4_+_76304911 0.38 ENSDART00000172734
ENSDART00000161850
si:ch73-389k6.1
si:ch73-389k6.1
chr25_+_36292465 0.36 ENSDART00000152649
bmb
brambleberry
chr2_-_7185460 0.35 ENSDART00000092078
rc3h1b
ring finger and CCCH-type domains 1b
chr7_+_34487833 0.35 ENSDART00000173854
cln6a
CLN6, transmembrane ER protein a
chr17_+_49091661 0.34 ENSDART00000177166
ENSDART00000177390
ENSDART00000190114
tiam2a
T cell lymphoma invasion and metastasis 2a
chr13_+_33368140 0.34 ENSDART00000033848
brf1a
BRF1, RNA polymerase III transcription initiation factor a
chr11_+_24348425 0.33 ENSDART00000089747
nfs1
NFS1 cysteine desulfurase
chr5_-_62988463 0.31 ENSDART00000047143
specc1
sperm antigen with calponin homology and coiled-coil domains 1
chr25_-_3745393 0.31 ENSDART00000037973
morc2
MORC family CW-type zinc finger 2
chr4_+_23127104 0.29 ENSDART00000139543
mdm2
MDM2 oncogene, E3 ubiquitin protein ligase
chr3_+_31680592 0.29 ENSDART00000172456
mylk5
myosin, light chain kinase 5
chr3_+_62219158 0.29 ENSDART00000162354
BX470259.5

chr18_-_38270077 0.28 ENSDART00000185546
caprin1b
cell cycle associated protein 1b
chr5_-_1999417 0.26 ENSDART00000155437
ENSDART00000145781
si:ch211-160e1.5
si:ch211-160e1.5
chr20_-_54462551 0.25 ENSDART00000171769
ENSDART00000169692
evlb
Enah/Vasp-like b
chr5_+_6854498 0.24 ENSDART00000148663
elac1
elaC ribonuclease Z 1
chr4_+_23126558 0.23 ENSDART00000162859
mdm2
MDM2 oncogene, E3 ubiquitin protein ligase
chr4_+_23127284 0.23 ENSDART00000122675
mdm2
MDM2 oncogene, E3 ubiquitin protein ligase
chr25_-_13659249 0.22 ENSDART00000045488
csnk2a2b
casein kinase 2, alpha prime polypeptide b
chr16_-_19568795 0.22 ENSDART00000185141
abcb5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr10_+_36029537 0.22 ENSDART00000165386
hmgb1a
high mobility group box 1a
chr16_+_54829293 0.21 ENSDART00000024729
pabpc1a
poly(A) binding protein, cytoplasmic 1a
chr13_-_17464362 0.20 ENSDART00000145499
lrmda
leucine rich melanocyte differentiation associated
chr3_+_52545400 0.19 ENSDART00000184183
slc27a1a
solute carrier family 27 (fatty acid transporter), member 1a
chr6_+_13046720 0.18 ENSDART00000165896
casp8
caspase 8, apoptosis-related cysteine peptidase
chr20_+_4157815 0.18 ENSDART00000113132
gnpat
glyceronephosphate O-acyltransferase
chr16_+_39196727 0.18 ENSDART00000017017
zdhhc3a
zinc finger, DHHC-type containing 3a
chr20_+_48100261 0.17 ENSDART00000158604
xkr5a
XK related 5a
chr4_+_25693463 0.15 ENSDART00000132864
acot18
acyl-CoA thioesterase 18
chr6_+_54888493 0.14 ENSDART00000113331
nav1b
neuron navigator 1b
chr22_+_15979430 0.13 ENSDART00000189703
ENSDART00000192674
rc3h1a
ring finger and CCCH-type domains 1a
chr9_-_52598343 0.13 ENSDART00000167922
xrcc5
X-ray repair complementing defective repair in Chinese hamster cells 5
chr11_-_21363834 0.11 ENSDART00000080051
RASSF5
si:dkey-85p17.3
chr8_+_52515188 0.11 ENSDART00000163668
si:ch1073-392o20.2
si:ch1073-392o20.2
chr2_+_23352302 0.09 ENSDART00000187760
rnf2
ring finger protein 2
chr7_-_16596938 0.09 ENSDART00000134548
e2f8
E2F transcription factor 8
chr25_+_4581214 0.09 ENSDART00000185552
CABZ01068600.1

chr7_-_72208248 0.08 ENSDART00000108916
zmp:0000001168
zmp:0000001168
chr7_-_16597130 0.06 ENSDART00000144118
e2f8
E2F transcription factor 8
chr3_-_39488639 0.04 ENSDART00000161644
zgc:100868
zgc:100868
chr6_-_40885496 0.04 ENSDART00000189857
sirt4
sirtuin 4
chr3_-_39488482 0.02 ENSDART00000135192
zgc:100868
zgc:100868
chr18_+_20567542 0.02 ENSDART00000182585
bida
BH3 interacting domain death agonist
chr11_+_24994705 0.02 ENSDART00000129211
zgc:92107
zgc:92107
chr12_-_44151296 0.02 ENSDART00000168734
si:ch73-329n5.3
si:ch73-329n5.3
chr8_-_22739757 0.02 ENSDART00000182167
ENSDART00000171891
iqsec2a
IQ motif and Sec7 domain 2a
chr13_-_9300299 0.02 ENSDART00000144142
HTRA2 (1 of many)
si:dkey-33c12.12
chr21_+_44857293 0.01 ENSDART00000134365
ENSDART00000168217
ENSDART00000065083
fstl4
follistatin-like 4
chr6_-_2154137 0.01 ENSDART00000162656
tgm5l
transglutaminase 5, like
chr7_+_19495905 0.01 ENSDART00000125584
ENSDART00000173774
si:ch211-212k18.8
si:ch211-212k18.8

Network of associatons between targets according to the STRING database.

First level regulatory network of tp73

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:1901890 positive regulation of cell junction assembly(GO:1901890)
0.2 0.8 GO:1904036 negative regulation of epithelial cell apoptotic process(GO:1904036)
0.1 0.2 GO:0050787 response to mercury ion(GO:0046689) detoxification of mercury ion(GO:0050787)
0.1 0.6 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.1 0.4 GO:0007344 karyogamy(GO:0000741) pronuclear fusion(GO:0007344)
0.1 0.4 GO:0006083 acetate metabolic process(GO:0006083) acetyl-CoA biosynthetic process from acetate(GO:0019427)
0.1 0.2 GO:0042779 tRNA 3'-trailer cleavage(GO:0042779)
0.1 0.2 GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism(GO:0043903)
0.1 0.2 GO:0046504 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) cellular lipid biosynthetic process(GO:0097384) ether biosynthetic process(GO:1901503)
0.0 0.5 GO:0035283 central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.0 0.2 GO:0033301 cell cycle comprising mitosis without cytokinesis(GO:0033301)
0.0 0.2 GO:0031650 heat generation(GO:0031649) regulation of heat generation(GO:0031650) positive regulation of heat generation(GO:0031652) regulation of phospholipid biosynthetic process(GO:0071071) negative regulation of phospholipid biosynthetic process(GO:0071072)
0.0 0.4 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.0 0.1 GO:0010332 response to gamma radiation(GO:0010332) cellular response to gamma radiation(GO:0071480)
0.0 0.3 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.9 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 0.5 GO:0032836 glomerular basement membrane development(GO:0032836)
0.0 0.3 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.2 GO:0070782 phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.0 0.3 GO:0070897 DNA-templated transcriptional preinitiation complex assembly(GO:0070897)
0.0 0.2 GO:0009409 response to cold(GO:0009409)
0.0 0.1 GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902254)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0016600 flotillin complex(GO:0016600)
0.0 0.3 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.0 0.1 GO:0043194 axon initial segment(GO:0043194)
0.0 0.9 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.7 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.2 GO:0005956 protein kinase CK2 complex(GO:0005956)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1 0.2 GO:0042781 3'-tRNA processing endoribonuclease activity(GO:0042781)
0.1 0.4 GO:0050218 propionate-CoA ligase activity(GO:0050218)
0.1 0.5 GO:0035613 RNA stem-loop binding(GO:0035613)
0.0 0.3 GO:0000995 transcription factor activity, core RNA polymerase III binding(GO:0000995)
0.0 0.4 GO:1990404 protein ADP-ribosylase activity(GO:1990404)
0.0 0.2 GO:0019107 myristoyltransferase activity(GO:0019107)
0.0 0.2 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.3 GO:0005522 profilin binding(GO:0005522)
0.0 0.3 GO:0016783 sulfurtransferase activity(GO:0016783)
0.0 0.3 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.2 GO:0001130 bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding(GO:0001130) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217)
0.0 0.2 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.9 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.5 GO:0004629 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.0 0.2 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.0 0.2 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.0 0.2 GO:0008301 DNA binding, bending(GO:0008301)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.2 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.5 PID RAS PATHWAY Regulation of Ras family activation
0.0 0.4 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.9 PID P53 REGULATION PATHWAY p53 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 0.8 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 0.5 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.2 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.1 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus