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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for wt1a+wt1b
Z-value: 1.90
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Transcription factors associated with wt1a+wt1b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| wt1a | dr11_v1_chr25_-_15214161_15214161 | 0.88 | 1.5e-06 | Click! |
| wt1b | dr11_v1_chr18_-_45617146_45617146 | 0.39 | 1.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr20_-_147574 Show fit | 7.05 |
ENSDART00000104762
ENSDART00000131635 |
solute carrier family 16 (aromatic amino acid transporter), member 10 |
|
| chr16_-_54405976 Show fit | 6.64 |
ENSDART00000055395
|
odd-skipped related transciption factor 2 |
|
| chr15_+_31526225 Show fit | 6.48 |
ENSDART00000154456
|
WD40 repeat domain 95 |
|
| chr2_-_44183613 Show fit | 5.98 |
ENSDART00000079596
|
cell adhesion molecule 3 |
|
| chr6_-_60104628 Show fit | 5.78 |
ENSDART00000057463
ENSDART00000169188 |
prostate transmembrane protein, androgen induced 1 |
|
| chr3_-_22829710 Show fit | 5.40 |
ENSDART00000055659
|
cytochrome b561 |
|
| chr7_-_10560964 Show fit | 5.30 |
ENSDART00000172761
ENSDART00000170476 |
5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase) |
|
| chr2_-_44183451 Show fit | 5.00 |
ENSDART00000111246
|
cell adhesion molecule 3 |
|
| chr1_-_59422880 Show fit | 4.98 |
ENSDART00000167244
|
si:ch211-188p14.2 |
|
| chr7_+_16166558 Show fit | 4.90 |
ENSDART00000173785
|
si:ch73-367j5.3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of wt1a+wt1b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 20.9 | GO:0046777 | protein autophosphorylation(GO:0046777) |
| 0.1 | 8.8 | GO:0045732 | positive regulation of protein catabolic process(GO:0045732) |
| 1.2 | 5.8 | GO:0071071 | heat generation(GO:0031649) regulation of heat generation(GO:0031650) positive regulation of heat generation(GO:0031652) regulation of phospholipid biosynthetic process(GO:0071071) negative regulation of phospholipid biosynthetic process(GO:0071072) |
| 0.8 | 5.8 | GO:0060394 | negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394) |
| 0.1 | 5.7 | GO:0010466 | negative regulation of peptidase activity(GO:0010466) |
| 0.1 | 5.5 | GO:0001945 | lymph vessel development(GO:0001945) |
| 0.1 | 5.4 | GO:0022900 | electron transport chain(GO:0022900) |
| 0.8 | 5.3 | GO:0009396 | folic acid-containing compound biosynthetic process(GO:0009396) |
| 0.3 | 4.5 | GO:0043248 | proteasome assembly(GO:0043248) |
| 0.3 | 4.0 | GO:0036158 | outer dynein arm assembly(GO:0036158) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.0 | GO:0000786 | nucleosome(GO:0000786) |
| 0.4 | 4.5 | GO:0008541 | proteasome regulatory particle, lid subcomplex(GO:0008541) |
| 0.0 | 4.3 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.0 | 4.1 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.3 | 4.0 | GO:0036157 | outer dynein arm(GO:0036157) |
| 0.2 | 3.9 | GO:0008278 | cohesin complex(GO:0008278) |
| 0.2 | 3.8 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.3 | 3.7 | GO:0002178 | palmitoyltransferase complex(GO:0002178) |
| 1.2 | 3.6 | GO:0000333 | telomerase catalytic core complex(GO:0000333) |
| 0.3 | 3.5 | GO:1990246 | uniplex complex(GO:1990246) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 12.4 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 1.8 | 7.1 | GO:0015349 | thyroid hormone transmembrane transporter activity(GO:0015349) |
| 0.1 | 6.6 | GO:0042826 | histone deacetylase binding(GO:0042826) |
| 1.2 | 5.8 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.2 | 5.6 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
| 0.0 | 5.6 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 5.5 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 1.8 | 5.4 | GO:0000293 | ferric-chelate reductase activity(GO:0000293) |
| 0.7 | 5.0 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 0.2 | 4.7 | GO:0097472 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 17.0 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 5.7 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.2 | 5.6 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.1 | 3.6 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 3.5 | NABA MATRISOME ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
| 0.0 | 3.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.4 | 2.3 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.1 | 2.1 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.0 | 1.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 1.6 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 12.8 | REACTOME SIGNALING BY ERBB4 | Genes involved in Signaling by ERBB4 |
| 0.4 | 8.8 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.3 | 5.8 | REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS | Genes involved in TGF-beta receptor signaling activates SMADs |
| 0.1 | 3.9 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.1 | 3.6 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.1 | 3.6 | REACTOME TELOMERE MAINTENANCE | Genes involved in Telomere Maintenance |
| 0.1 | 3.0 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.3 | 2.9 | REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 0.2 | 2.7 | REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR | Genes involved in Thromboxane signalling through TP receptor |
| 0.1 | 2.7 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |