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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for zbtb3

Z-value: 0.53

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Transcription factors associated with zbtb3

Gene Symbol Gene ID Gene Info
ENSDARG00000036235 zinc finger and BTB domain containing 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
zbtb3dr11_v1_chr14_+_35405518_35405518-0.475.1e-02Click!

Activity profile of zbtb3 motif

Sorted Z-values of zbtb3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_52398205 2.96 ENSDART00000143225
si:ch211-217k17.9
chr6_+_13039951 1.33 ENSDART00000091700
ciliogenesis associated TTC17 interacting protein
chr23_-_32404022 1.28 ENSDART00000156387
ENSDART00000155508
si:ch211-66i15.4
chr22_-_25469751 1.15 ENSDART00000171670

chr14_+_6546516 1.02 ENSDART00000097214
ADAM metallopeptidase domain 19b
chr1_+_50921266 0.98 ENSDART00000006538
orthodenticle homeobox 2a
chr25_+_13662606 0.87 ENSDART00000008989
coiled-coil domain containing 113
chr22_-_25502977 0.86 ENSDART00000181749

chr1_-_44704261 0.78 ENSDART00000133210
si:dkey-28b4.8
chr18_+_7611298 0.73 ENSDART00000062156
outer dense fiber of sperm tails 3B
chr14_-_1355544 0.70 ENSDART00000060417
centrin 4
chr16_-_32013913 0.63 ENSDART00000030282
ENSDART00000138701
glutathione S-transferase kappa 1
chr16_+_32092866 0.56 ENSDART00000137785
si:dkey-40m6.11
chr5_+_9297585 0.46 ENSDART00000170557
si:ch73-194c23.1
chr13_-_2215213 0.43 ENSDART00000129773
muscular LMNA-interacting protein
chr3_+_24458899 0.42 ENSDART00000156655
chromobox homolog 6b
chr3_-_24458281 0.42 ENSDART00000153993
BAI1-associated protein 2-like 2a
chr22_-_18387059 0.40 ENSDART00000007769
testis-specific serine kinase 6
chr7_-_35432901 0.38 ENSDART00000026712
matrix metallopeptidase 2
chr19_-_7240627 0.37 ENSDART00000181874

chr12_-_35885349 0.36 ENSDART00000085662
centrosomal protein 131
chr20_+_25340814 0.36 ENSDART00000063028
connective tissue growth factor a
chr13_-_37127970 0.35 ENSDART00000135510
spectrin repeat containing, nuclear envelope 2b
chr2_-_985417 0.34 ENSDART00000140540
si:ch211-241e1.3
chr3_+_24458204 0.30 ENSDART00000155028
ENSDART00000153551
chromobox homolog 6b
chr17_-_11151655 0.30 ENSDART00000156383

chr10_+_44641599 0.29 ENSDART00000172128
seizure related 6 homolog (mouse)-like
chr9_-_8979154 0.28 ENSDART00000145266
inhibitor of growth family, member 1
chr19_-_19442983 0.28 ENSDART00000052649
sb:cb649
chr21_+_45366229 0.28 ENSDART00000029946
ubiquitin-conjugating enzyme E2B (RAD6 homolog)
chr14_-_32258759 0.27 ENSDART00000052949
fibroblast growth factor 13a
chr7_-_25895189 0.27 ENSDART00000173599
ENSDART00000079235
ENSDART00000173786
ENSDART00000173602
ENSDART00000079245
ENSDART00000187568
ENSDART00000173505
CD99 molecule-like 2
chr7_+_34492744 0.26 ENSDART00000109635
ENSDART00000173844
calmodulin-like 4a
chr20_+_39375280 0.26 ENSDART00000172434
Pim proto-oncogene, serine/threonine kinase, related 131
chr14_-_23801389 0.25 ENSDART00000054264
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr1_-_54425791 0.25 ENSDART00000039911
polycystic kidney disease 1a
chr10_-_4375190 0.24 ENSDART00000016102

chr7_-_26087807 0.24 ENSDART00000052989
acetylcholinesterase
chr16_+_4695075 0.23 ENSDART00000039054
mitochondrial trans-2-enoyl-CoA reductase
chr21_-_4923427 0.22 ENSDART00000181489
potassium channel, subfamily T, member 1
chr16_-_42872571 0.21 ENSDART00000154757
ENSDART00000102345
thioredoxin interacting protein b
chr13_+_771403 0.21 ENSDART00000093166
neurexin 1b
chr20_+_38671894 0.20 ENSDART00000146544
MpV17 mitochondrial inner membrane protein
chr18_+_37015185 0.19 ENSDART00000191305
signal-induced proliferation-associated 1 like 3
chr23_-_29878643 0.19 ENSDART00000058407
solute carrier family 25 (pyrimidine nucleotide carrier), member 33
chr3_+_53240562 0.18 ENSDART00000031234
syntaxin binding protein 2
chr19_+_917852 0.17 ENSDART00000082466
transforming growth factor beta receptor 2a
chr4_-_68913650 0.16 ENSDART00000184297
si:dkey-264f17.5
chr1_-_633356 0.16 ENSDART00000171019
amyloid beta (A4) precursor protein a
chr16_+_10422836 0.15 ENSDART00000161568
INO80 complex subunit E
chr24_-_26383978 0.15 ENSDART00000031426
SKI-like proto-oncogene b
chr5_+_61799629 0.14 ENSDART00000113508
heterogeneous nuclear ribonucleoprotein U-like 1 like
chr19_-_35439237 0.14 ENSDART00000145883
anillin, actin binding protein
chr12_+_48220584 0.14 ENSDART00000164392
leucine rich repeat containing 20
chr10_+_26944978 0.14 ENSDART00000192148
FERM domain containing 8
chr20_-_6131686 0.14 ENSDART00000145964
ENSDART00000086578
ENSDART00000164090
pumilio RNA-binding family member 2
chr3_-_34069637 0.14 ENSDART00000151588
immunoglobulin heavy variable 9-1
chr8_-_54304381 0.12 ENSDART00000184177
rhodopsin
chr4_+_38550788 0.12 ENSDART00000157412
si:ch211-209n20.1
chr14_+_1355857 0.11 ENSDART00000188008
Bardet-Biedl syndrome 12
chr2_-_27329214 0.11 ENSDART00000145835
thioredoxin related transmembrane protein 3a
chr21_+_35296246 0.10 ENSDART00000076750
interleukin 12B, b
chr10_+_31951338 0.10 ENSDART00000019416
LHFPL tetraspan subfamily member 6
chr8_+_3820134 0.10 ENSDART00000122454
citron rho-interacting serine/threonine kinase b
chr3_-_61185746 0.10 ENSDART00000028219
parvalbumin 4
chr8_-_1884955 0.10 ENSDART00000081563
si:dkey-178e17.3
chr18_-_43880020 0.09 ENSDART00000185638
DEAD (Asp-Glu-Ala-Asp) box helicase 6
chr18_-_50839033 0.08 ENSDART00000169773
damage-specific DNA binding protein 1
chr23_+_39558508 0.08 ENSDART00000017902
calcium/calmodulin-dependent protein kinase IGb
chr3_+_61185660 0.08 ENSDART00000167114

chr22_-_29336268 0.08 ENSDART00000132776
ENSDART00000186351
ENSDART00000121599
platelet-derived growth factor beta polypeptide a
chr17_+_34215886 0.08 ENSDART00000186775
membrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5)
chr2_+_5621529 0.07 ENSDART00000144187
fibroblast growth factor 12a
chr22_+_3238474 0.07 ENSDART00000157954
si:ch1073-178p5.3
chr19_+_42770041 0.07 ENSDART00000150930
cytoplasmic linker associated protein 2
chr8_+_26293673 0.06 ENSDART00000144977
monoglyceride lipase
chr6_-_51556308 0.06 ENSDART00000149033
retinoblastoma-like 1 (p107)
chr17_-_29311835 0.06 ENSDART00000104224
tectonin beta-propeller repeat containing 2
chr1_+_532766 0.05 ENSDART00000179731
ENSDART00000060944
mitochondrial ribosomal protein L39
chr2_+_45643122 0.04 ENSDART00000138179
fibronectin type III domain containing 7, related sequence 4
chr15_-_576135 0.04 ENSDART00000124170
cerebellin 20
chr18_+_7309150 0.04 ENSDART00000052792
ceramide synthase 3b
chr11_+_1805421 0.04 ENSDART00000173143
low density lipoprotein receptor-related protein 1Aa
chr2_+_45484183 0.04 ENSDART00000183490
si:ch211-66k16.28
chr22_-_8353386 0.03 ENSDART00000077600

chr24_-_24146875 0.03 ENSDART00000173052
MAP7 domain containing 2b
chr25_-_35542739 0.03 ENSDART00000097651
si:ch211-87j1.4
chr11_-_36156935 0.03 ENSDART00000124935
ENSDART00000138609
BRICK1, SCAR/WAVE actin-nucleating complex subunit
glutathione peroxidase 1a
chr16_+_34531486 0.03 ENSDART00000043291
progestin and adipoQ receptor family member VII, b
chr9_-_32753535 0.03 ENSDART00000060006
oligodendrocyte lineage transcription factor 2
chr15_+_863931 0.03 ENSDART00000154083
si:dkey-7i4.12
chr1_-_22687913 0.03 ENSDART00000168171
fibroblast growth factor binding protein 2b
chr6_-_40921412 0.03 ENSDART00000076097
ENSDART00000188364
SFI1 centrin binding protein
chr5_+_53580846 0.03 ENSDART00000184967
ENSDART00000161751
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr13_+_23282549 0.03 ENSDART00000101134
KH domain containing, RNA binding, signal transduction associated 2
chr6_-_38419318 0.02 ENSDART00000138026
gamma-aminobutyric acid (GABA) A receptor, alpha 5
chr22_-_11136625 0.02 ENSDART00000016873
ENSDART00000125561
ATPase H+ transporting accessory protein 2
chr7_-_6592142 0.02 ENSDART00000160137
potassium inwardly-rectifying channel, subfamily J, member 10a
chr6_-_39006449 0.02 ENSDART00000150885
vitamin D receptor b
chr5_-_20446082 0.02 ENSDART00000051607
si:ch211-191d15.2
chr16_-_14552199 0.02 ENSDART00000133368
si:dkey-237j11.3
chr1_+_59007536 0.01 ENSDART00000165339
cell division cycle 37
chr7_+_17938128 0.01 ENSDART00000141044
metastasis associated 1 family, member 2
chr15_-_19705707 0.00 ENSDART00000047643
synaptotagmin-like 2b

Network of associatons between targets according to the STRING database.

First level regulatory network of zbtb3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0021846 cell proliferation in forebrain(GO:0021846)
0.1 0.2 GO:0009193 pyrimidine ribonucleoside diphosphate metabolic process(GO:0009193) UDP metabolic process(GO:0046048)
0.1 0.3 GO:0071548 cellular response to cortisol stimulus(GO:0071387) response to dexamethasone(GO:0071548)
0.1 0.3 GO:0032965 regulation of collagen metabolic process(GO:0010712) regulation of collagen biosynthetic process(GO:0032965) regulation of multicellular organismal metabolic process(GO:0044246)
0.1 0.2 GO:1990519 pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
0.1 0.2 GO:0008291 acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)
0.1 1.0 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.1 0.4 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.1 0.4 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.0 0.1 GO:0008356 asymmetric cell division(GO:0008356)
0.0 1.0 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.0 0.1 GO:0018171 peptidyl-cysteine oxidation(GO:0018171)
0.0 0.3 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.0 0.4 GO:0035701 hematopoietic stem cell migration(GO:0035701)
0.0 0.3 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.7 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.1 GO:0045475 locomotor rhythm(GO:0045475)
0.0 0.1 GO:0034063 stress granule assembly(GO:0034063)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 GO:0034451 centriolar satellite(GO:0034451)
0.1 0.3 GO:0033503 HULC complex(GO:0033503)
0.0 0.8 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.1 GO:0043514 interleukin-12 complex(GO:0043514) interleukin-23 complex(GO:0070743)
0.0 0.1 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 1.3 GO:0036064 ciliary basal body(GO:0036064)
0.0 0.7 GO:0005814 centriole(GO:0005814)
0.0 0.4 GO:0016605 PML body(GO:0016605)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0005521 lamin binding(GO:0005521)
0.1 0.2 GO:0015218 pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
0.0 0.8 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.2 GO:0004104 cholinesterase activity(GO:0004104)
0.0 0.7 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.2 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 0.1 GO:0042164 interleukin-12 binding(GO:0019972) interleukin-12 alpha subunit binding(GO:0042164)
0.0 1.0 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.1 GO:0016972 thiol oxidase activity(GO:0016972)
0.0 0.3 GO:0017080 sodium channel regulator activity(GO:0017080)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.2 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC