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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for zeb1a+zeb1b
Z-value: 1.90
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Transcription factors associated with zeb1a+zeb1b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| zeb1b | dr11_v1_chr12_-_26851726_26851726 | -0.92 | 9.8e-08 | Click! |
| zeb1a | dr11_v1_chr2_-_43852207_43852207 | 0.83 | 2.4e-05 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr15_+_20239141 Show fit | 7.65 |
ENSDART00000101152
ENSDART00000152473 |
serine peptidase inhibitor, Kunitz type, 2 |
|
| chr2_+_68789 Show fit | 6.62 |
ENSDART00000058569
|
claudin 1 |
|
| chr10_-_2942900 Show fit | 6.40 |
ENSDART00000002622
|
occludin a |
|
| chr5_+_22974019 Show fit | 5.95 |
ENSDART00000147157
ENSDART00000020434 |
bromodomain and WD repeat domain containing 3 |
|
| chr6_-_7776612 Show fit | 5.85 |
ENSDART00000190269
|
myosin, heavy chain 9a, non-muscle |
|
| chr12_-_11349899 Show fit | 5.72 |
ENSDART00000079645
|
zgc:174164 |
|
| chr13_-_21672131 Show fit | 5.29 |
ENSDART00000067537
|
ELOVL family member 6, elongation of long chain fatty acids like |
|
| chr5_-_33236637 Show fit | 5.19 |
ENSDART00000085512
ENSDART00000144694 |
KN motif and ankyrin repeat domains 1b |
|
| chr3_+_43086548 Show fit | 5.13 |
ENSDART00000163579
|
si:dkey-43p13.5 |
|
| chr7_+_58751504 Show fit | 5.03 |
ENSDART00000024185
|
zgc:56231 |
Network of associatons between targets according to the STRING database.
First level regulatory network of zeb1a+zeb1b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.4 | GO:0051604 | protein maturation(GO:0051604) |
| 0.1 | 12.4 | GO:0090630 | activation of GTPase activity(GO:0090630) |
| 0.6 | 10.6 | GO:0007339 | binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344) |
| 0.2 | 9.8 | GO:0043297 | apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830) |
| 0.5 | 9.7 | GO:0019367 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
| 0.4 | 8.7 | GO:0090557 | establishment of endothelial intestinal barrier(GO:0090557) |
| 0.1 | 8.6 | GO:0061640 | cytoskeleton-dependent cytokinesis(GO:0061640) |
| 1.7 | 8.5 | GO:0072104 | renal system vasculature morphogenesis(GO:0061438) kidney vasculature morphogenesis(GO:0061439) glomerulus vasculature morphogenesis(GO:0072103) glomerular capillary formation(GO:0072104) |
| 1.0 | 8.1 | GO:0070493 | thrombin receptor signaling pathway(GO:0070493) |
| 0.2 | 7.0 | GO:0016180 | snRNA processing(GO:0016180) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 31.3 | GO:0070160 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
| 0.0 | 15.9 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.7 | 14.8 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.0 | 11.2 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.1 | 9.3 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.1 | 8.9 | GO:0016459 | myosin complex(GO:0016459) |
| 0.2 | 7.8 | GO:0032156 | septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156) |
| 0.0 | 7.7 | GO:0005794 | Golgi apparatus(GO:0005794) |
| 0.1 | 7.4 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.5 | 6.8 | GO:0048179 | activin receptor complex(GO:0048179) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 15.2 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.1 | 14.8 | GO:0003774 | motor activity(GO:0003774) |
| 0.6 | 11.1 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.1 | 10.7 | GO:0050839 | cell adhesion molecule binding(GO:0050839) |
| 0.9 | 10.4 | GO:0035804 | structural constituent of egg coat(GO:0035804) |
| 0.0 | 10.0 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.1 | 9.9 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.5 | 9.7 | GO:0102336 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 0.3 | 8.2 | GO:0015248 | sterol transporter activity(GO:0015248) |
| 1.0 | 8.1 | GO:0015057 | thrombin receptor activity(GO:0015057) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 11.8 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.3 | 9.5 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
| 0.1 | 7.9 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.3 | 6.7 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.2 | 6.5 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 4.7 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.3 | 4.6 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.2 | 3.4 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.2 | 3.1 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.1 | 2.6 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 7.0 | REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
| 0.7 | 6.5 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.5 | 6.5 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.6 | 6.3 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 1.2 | 5.8 | REACTOME ACYL CHAIN REMODELLING OF PS | Genes involved in Acyl chain remodelling of PS |
| 0.1 | 5.8 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.3 | 5.3 | REACTOME PYRUVATE METABOLISM | Genes involved in Pyruvate metabolism |
| 1.4 | 4.2 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.2 | 4.0 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.1 | 4.0 | REACTOME METABOLISM OF NON CODING RNA | Genes involved in Metabolism of non-coding RNA |