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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for znf711
Z-value: 1.51
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Transcription factors associated with znf711
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| znf711 | dr11_v1_chr14_-_12020653_12020653 | 0.39 | 1.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr23_-_10175898 Show fit | 6.17 |
ENSDART00000146185
|
keratin 5 |
|
| chr5_-_72390259 Show fit | 4.38 |
ENSDART00000172302
|
WW domain binding protein 1 |
|
| chr19_-_27830818 Show fit | 4.33 |
ENSDART00000131767
|
PAP associated domain containing 7 |
|
| chr2_+_23007675 Show fit | 3.65 |
ENSDART00000163649
|
MAP kinase interacting serine/threonine kinase 2a |
|
| chr22_-_817479 Show fit | 3.18 |
ENSDART00000123487
|
zgc:153675 |
|
| chr22_-_10541712 Show fit | 3.06 |
ENSDART00000013933
|
si:dkey-42i9.4 |
|
| chr20_-_43742822 Show fit | 3.05 |
ENSDART00000181729
|
si:dkeyp-50f7.2 |
|
| chr19_+_31585917 Show fit | 2.99 |
ENSDART00000132182
|
geminin, DNA replication inhibitor |
|
| chr18_+_15271993 Show fit | 2.90 |
ENSDART00000099777
|
si:dkey-103i16.6 |
|
| chr19_+_31585341 Show fit | 2.90 |
ENSDART00000052185
|
geminin, DNA replication inhibitor |
Network of associatons between targets according to the STRING database.
First level regulatory network of znf711
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.7 | GO:0031101 | fin regeneration(GO:0031101) |
| 0.3 | 8.0 | GO:0008156 | negative regulation of DNA replication(GO:0008156) |
| 0.1 | 5.3 | GO:0044744 | protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744) single-organism nuclear import(GO:1902593) |
| 0.3 | 4.9 | GO:0035090 | maintenance of apical/basal cell polarity(GO:0035090) maintenance of epithelial cell apical/basal polarity(GO:0045199) |
| 0.1 | 4.6 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.0 | 4.1 | GO:0008285 | negative regulation of cell proliferation(GO:0008285) |
| 0.0 | 4.0 | GO:0018105 | peptidyl-serine phosphorylation(GO:0018105) |
| 0.1 | 3.7 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123) |
| 0.2 | 3.6 | GO:0043966 | histone H3 acetylation(GO:0043966) |
| 0.1 | 2.8 | GO:0030968 | endoplasmic reticulum unfolded protein response(GO:0030968) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 8.8 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 8.0 | GO:0005730 | nucleolus(GO:0005730) |
| 0.0 | 5.6 | GO:0000785 | chromatin(GO:0000785) |
| 0.1 | 4.5 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.9 | 3.4 | GO:0098890 | extrinsic component of postsynaptic membrane(GO:0098890) |
| 0.2 | 3.0 | GO:0070776 | H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776) |
| 0.7 | 2.7 | GO:1902737 | dendritic spine neck(GO:0044326) dendritic filopodium(GO:1902737) |
| 0.1 | 2.7 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
| 0.0 | 2.7 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.2 | 2.3 | GO:0034751 | aryl hydrocarbon receptor complex(GO:0034751) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.3 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.0 | 6.3 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.2 | 6.0 | GO:0019003 | GDP binding(GO:0019003) |
| 0.3 | 5.3 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.5 | 4.3 | GO:0017091 | AU-rich element binding(GO:0017091) mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.1 | 3.9 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
| 0.2 | 3.6 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.3 | 3.4 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.0 | 3.3 | GO:0000989 | transcription factor activity, transcription factor binding(GO:0000989) transcription cofactor activity(GO:0003712) |
| 0.1 | 3.2 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.8 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.2 | 4.9 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.4 | 3.6 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.1 | 3.3 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.1 | 2.3 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.1 | 2.1 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.1 | 2.0 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 1.8 | PID ERBB2 ERBB3 PATHWAY | ErbB2/ErbB3 signaling events |
| 0.1 | 1.6 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 1.3 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 5.3 | REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX | Genes involved in Association of licensing factors with the pre-replicative complex |
| 0.5 | 4.9 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.2 | 4.3 | REACTOME DESTABILIZATION OF MRNA BY KSRP | Genes involved in Destabilization of mRNA by KSRP |
| 0.3 | 3.7 | REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION | Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
| 0.1 | 2.8 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.2 | 2.7 | REACTOME RNA POL III CHAIN ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |
| 0.1 | 2.6 | REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |
| 0.2 | 2.3 | REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 | Genes involved in Regulation of AMPK activity via LKB1 |
| 0.2 | 2.3 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.1 | 2.3 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |