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12D miR HR13_24

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Results for Nfatc4

Z-value: 0.33

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Transcription factors associated with Nfatc4

Gene Symbol Gene ID Gene Info
ENSMUSG00000023411.5 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nfatc4mm10_v2_chr14_+_55824795_558248890.088.3e-01Click!

Activity profile of Nfatc4 motif

Sorted Z-values of Nfatc4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr10_+_4611971 0.51 ENSMUST00000105590.1
ENSMUST00000067086.7
estrogen receptor 1 (alpha)
chr11_-_83530505 0.35 ENSMUST00000035938.2
chemokine (C-C motif) ligand 5
chr7_-_4778141 0.27 ENSMUST00000094892.5
interleukin 11
chr12_+_91400990 0.22 ENSMUST00000021346.7
ENSMUST00000021343.6
thyroid stimulating hormone receptor
chr2_+_72285637 0.21 ENSMUST00000090824.5
ENSMUST00000135469.1
sterile alpha motif and leucine zipper containing kinase AZK
chr16_-_75909272 0.20 ENSMUST00000114239.2
SAM domain, SH3 domain and nuclear localization signals, 1
chr12_+_7977640 0.15 ENSMUST00000171271.1
ENSMUST00000037811.6
ENSMUST00000037520.7
apolipoprotein B
chr3_-_59635733 0.15 ENSMUST00000177879.1
predicted gene 5709
chr2_+_55435918 0.15 ENSMUST00000067101.3
potassium inwardly-rectifying channel, subfamily J, member 3
chr2_-_73453918 0.13 ENSMUST00000102679.1
WAS/WASL interacting protein family, member 1
chr17_-_70849644 0.13 ENSMUST00000134654.1
ENSMUST00000172229.1
ENSMUST00000127719.1
TGFB-induced factor homeobox 1
chr13_+_31806627 0.11 ENSMUST00000062292.2
forkhead box C1
chr1_-_144177259 0.11 ENSMUST00000111941.1
ENSMUST00000052375.1
regulator of G-protein signaling 13
chr3_+_84925476 0.09 ENSMUST00000107675.1
F-box and WD-40 domain protein 7
chr4_+_48049080 0.09 ENSMUST00000153369.1
nuclear receptor subfamily 4, group A, member 3
chr2_+_3114220 0.09 ENSMUST00000072955.5
family with sequence similarity 171, member A1
chr5_+_145114280 0.09 ENSMUST00000141602.1
actin related protein 2/3 complex, subunit 1B
chr1_-_64121389 0.08 ENSMUST00000055001.3
Kruppel-like factor 7 (ubiquitous)
chr16_+_38362205 0.08 ENSMUST00000023494.6
popeye domain containing 2
chr9_-_88731850 0.08 ENSMUST00000098486.2
B cell leukemia/lymphoma 2 related protein A1d
chr13_+_83504032 0.07 ENSMUST00000163888.1
ENSMUST00000005722.7
myocyte enhancer factor 2C
chr16_+_38362234 0.07 ENSMUST00000114739.1
popeye domain containing 2
chr6_+_134981998 0.07 ENSMUST00000167323.1
apolipoprotein L domain containing 1
chr15_+_3270767 0.07 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
selenoprotein P, plasma, 1
chr6_-_59024470 0.07 ENSMUST00000089860.5
family with sequence similarity 13, member A
chr2_-_66410064 0.07 ENSMUST00000112366.1
sodium channel, voltage-gated, type I, alpha
chr17_-_70851710 0.06 ENSMUST00000166395.2
TGFB-induced factor homeobox 1
chr11_-_58502554 0.06 ENSMUST00000170501.2
ENSMUST00000081743.2
olfactory receptor 331
chr11_+_97415527 0.06 ENSMUST00000121799.1
Rho GTPase activating protein 23
chr9_+_113812547 0.05 ENSMUST00000166734.2
ENSMUST00000111838.2
ENSMUST00000163895.2
CLIP associating protein 2
chr13_+_24943144 0.05 ENSMUST00000021773.5
glycosylphosphatidylinositol specific phospholipase D1
chr1_-_170110491 0.05 ENSMUST00000027985.2
discoidin domain receptor family, member 2
chr19_-_4943049 0.05 ENSMUST00000133254.1
ENSMUST00000120475.1
ENSMUST00000025834.7
pellino 3
chr3_-_106001474 0.05 ENSMUST00000066319.6
primary cilia formation
chr10_+_23851454 0.05 ENSMUST00000020190.7
vanin 3
chr18_+_73863672 0.05 ENSMUST00000134847.1
maestro
chr14_+_47663756 0.04 ENSMUST00000022391.7
kinectin 1
chr7_-_79920599 0.04 ENSMUST00000075657.6
adaptor-related protein complex 3, sigma 2 subunit
chr2_+_116067213 0.04 ENSMUST00000152412.1
RIKEN cDNA G630016G05 gene
chr19_+_8839298 0.04 ENSMUST00000160556.1
Bernardinelli-Seip congenital lipodystrophy 2 homolog (human)
chr1_-_150466165 0.04 ENSMUST00000162367.1
ENSMUST00000161611.1
ENSMUST00000161320.1
ENSMUST00000159035.1
proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)
chr1_-_64121456 0.04 ENSMUST00000142009.1
ENSMUST00000114086.1
Kruppel-like factor 7 (ubiquitous)
chr3_-_86548268 0.04 ENSMUST00000077524.3
mab-21-like 2 (C. elegans)
chr14_+_120275669 0.04 ENSMUST00000088419.6
ENSMUST00000167459.1
muscleblind-like 2
chr19_+_29101375 0.04 ENSMUST00000064393.5
RNA terminal phosphate cyclase-like 1
chr7_+_81114799 0.03 ENSMUST00000026820.4
solute carrier family 28 (sodium-coupled nucleoside transporter), member 1
chr2_-_73660351 0.03 ENSMUST00000154258.1
chimerin (chimaerin) 1
chr10_-_44458687 0.03 ENSMUST00000105490.2
PR domain containing 1, with ZNF domain
chr18_-_15063560 0.03 ENSMUST00000168989.1
potassium channel tetramerisation domain containing 1
chr8_-_41041828 0.03 ENSMUST00000051379.7
mitochondrial tumor suppressor 1
chr4_+_133176336 0.03 ENSMUST00000105912.1
WAS protein family, member 2
chr1_-_126830632 0.02 ENSMUST00000112583.1
ENSMUST00000094609.3
NCK-associated protein 5
chr7_+_81114816 0.02 ENSMUST00000119083.1
solute carrier family 28 (sodium-coupled nucleoside transporter), member 1
chr1_-_126830786 0.02 ENSMUST00000162646.1
NCK-associated protein 5
chr11_+_88718442 0.02 ENSMUST00000138007.1
RIKEN cDNA C030037D09 gene
chrX_-_7671341 0.02 ENSMUST00000033486.5
proteolipid protein 2
chr11_-_59571813 0.02 ENSMUST00000071943.2
olfactory receptor 222
chr8_-_64205970 0.02 ENSMUST00000066166.4
tolloid-like
chr10_-_44458715 0.02 ENSMUST00000039174.4
PR domain containing 1, with ZNF domain
chr12_-_86079019 0.02 ENSMUST00000003687.6
transforming growth factor, beta 3
chr14_-_25927250 0.02 ENSMUST00000100811.5
transmembrane protein 254a
chr3_+_94837533 0.02 ENSMUST00000107270.2
pogo transposable element with ZNF domain
chr7_-_84679346 0.02 ENSMUST00000069537.2
ENSMUST00000178385.1
zinc finger, AN1-type domain 6
chr12_+_31654848 0.01 ENSMUST00000036862.4
component of oligomeric golgi complex 5
chr5_+_53590215 0.01 ENSMUST00000037618.6
recombination signal binding protein for immunoglobulin kappa J region
chr19_-_8839181 0.01 ENSMUST00000096259.4
guanine nucleotide binding protein (G protein), gamma 3
chrX_-_23365044 0.01 ENSMUST00000115313.1
kelch-like 13
chr16_-_59555752 0.01 ENSMUST00000179383.1
ENSMUST00000044604.8
beta-gamma crystallin domain containing 3
chr4_-_148159838 0.01 ENSMUST00000151127.1
ENSMUST00000105705.2
F-box protein 44
chr15_+_92051153 0.00 ENSMUST00000169825.1
contactin 1
chr17_-_49564262 0.00 ENSMUST00000057610.6
dishevelled associated activator of morphogenesis 2
chr8_-_67818218 0.00 ENSMUST00000059374.4
pleckstrin and Sec7 domain containing 3
chr19_+_26623419 0.00 ENSMUST00000176584.1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr3_-_96594128 0.00 ENSMUST00000145001.1
ENSMUST00000091924.3
polymerase (RNA) III (DNA directed) polypeptide G like

Network of associatons between targets according to the STRING database.

First level regulatory network of Nfatc4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0060523 prostate epithelial cord elongation(GO:0060523)
0.1 0.4 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634) positive regulation of natural killer cell chemotaxis(GO:2000503)
0.0 0.1 GO:1990868 apoptotic process involved in outflow tract morphogenesis(GO:0003275) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256) response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869)
0.0 0.2 GO:1904587 response to glycoprotein(GO:1904587)
0.0 0.1 GO:0032765 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
0.0 0.1 GO:0010982 regulation of high-density lipoprotein particle clearance(GO:0010982)
0.0 0.2 GO:0060931 sinoatrial node cell development(GO:0060931)
0.0 0.1 GO:0007521 muscle cell fate determination(GO:0007521)
0.0 0.1 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.0 0.1 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.0 0.2 GO:0006642 triglyceride mobilization(GO:0006642)
0.0 0.1 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.0 0.1 GO:0015851 nucleobase transport(GO:0015851) pyrimidine nucleobase transport(GO:0015855)
0.0 0.2 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 0.1 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.2 GO:0031983 vesicle lumen(GO:0031983)
0.0 0.1 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.1 0.4 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.0 0.1 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.2 GO:0035473 lipase binding(GO:0035473)
0.0 0.1 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 0.1 GO:0015389 pyrimidine- and adenine-specific:sodium symporter activity(GO:0015389)
0.0 0.2 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.0 GO:0003963 RNA-3'-phosphate cyclase activity(GO:0003963)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.2 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors