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12D miR HR13_24

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Results for Irx5

Z-value: 0.51

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Transcription factors associated with Irx5

Gene Symbol Gene ID Gene Info
ENSMUSG00000031737.10 Iroquois homeobox 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Irx5mm10_v2_chr8_+_92357787_923578010.521.0e-01Click!

Activity profile of Irx5 motif

Sorted Z-values of Irx5 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_124321031 0.53 ENSMUST00000058994.4
translocation associated membrane protein 1-like 1
chr6_-_24956106 0.50 ENSMUST00000127247.2
transmembrane protein 229A
chr10_-_88146867 0.49 ENSMUST00000164121.1
ENSMUST00000164803.1
ENSMUST00000168163.1
ENSMUST00000048518.9
PARP1 binding protein
chr19_-_55241236 0.40 ENSMUST00000069183.6
guanylate cyclase 2g
chr17_+_7925990 0.39 ENSMUST00000036370.7
T cell activation Rho GTPase activating protein
chr2_+_25180737 0.35 ENSMUST00000104999.2
Notch-regulated ankyrin repeat protein
chr19_-_16780822 0.32 ENSMUST00000068156.6
vacuolar protein sorting 13A (yeast)
chr3_+_95124476 0.32 ENSMUST00000131597.1
ENSMUST00000005769.6
ENSMUST00000107227.1
tropomodulin 4
chr2_-_79908428 0.30 ENSMUST00000102652.3
ENSMUST00000102651.3
phosphodiesterase 1A, calmodulin-dependent
chr6_+_50110837 0.29 ENSMUST00000167628.1
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
chr2_-_5895319 0.29 ENSMUST00000026926.4
ENSMUST00000102981.3
Sec61, alpha subunit 2 (S. cerevisiae)
chr14_+_48120841 0.28 ENSMUST00000073150.4
pellino 2
chr3_-_88762244 0.28 ENSMUST00000183267.1
synaptotagmin XI
chr14_-_19977040 0.27 ENSMUST00000159028.1
guanine nucleotide binding protein (G protein), gamma 2
chr5_-_100429503 0.27 ENSMUST00000181873.1
ENSMUST00000180779.1
RIKEN cDNA 5430416N02 gene
chr3_+_19957037 0.26 ENSMUST00000091309.5
ENSMUST00000108329.1
ENSMUST00000003714.6
ceruloplasmin
chr14_-_19977151 0.26 ENSMUST00000055100.7
ENSMUST00000162425.1
guanine nucleotide binding protein (G protein), gamma 2
chr2_+_173153048 0.22 ENSMUST00000029017.5
phosphoenolpyruvate carboxykinase 1, cytosolic
chrX_+_20549780 0.20 ENSMUST00000023832.6
regucalcin
chr2_-_79908389 0.20 ENSMUST00000090756.4
phosphodiesterase 1A, calmodulin-dependent
chr9_-_110624361 0.19 ENSMUST00000035069.9
neurotrophin receptor associated death domain
chr1_-_173982842 0.18 ENSMUST00000000266.7
interferon activated gene 202B
chr3_-_158031705 0.18 ENSMUST00000072875.8
serine/arginine-rich splicing factor 11
chr7_-_142576492 0.17 ENSMUST00000140716.1
H19 fetal liver mRNA
chr2_-_151009364 0.17 ENSMUST00000109896.1
ninein-like
chr14_+_14820765 0.17 ENSMUST00000112631.2
ENSMUST00000178538.1
ENSMUST00000112630.2
NIMA (never in mitosis gene a)- related kinase 10
chr4_-_49521036 0.17 ENSMUST00000057829.3
mitochondrial ribosomal protein L50
chr15_-_77022632 0.16 ENSMUST00000019037.8
ENSMUST00000169226.1
myoglobin
chr11_+_78176711 0.15 ENSMUST00000098545.5
TLC domain containing 1
chr10_-_99759658 0.15 ENSMUST00000056085.4
citrate synthase like
chr5_-_144026596 0.14 ENSMUST00000031622.6
ENSMUST00000110702.1
oncomodulin
chr3_+_139205887 0.14 ENSMUST00000062306.6
sperm tail PG rich repeat containing 2
chr8_+_85171322 0.13 ENSMUST00000076896.5
predicted gene 6531
chr10_+_79960145 0.12 ENSMUST00000045247.7
WD repeat domain 18
chr1_-_173227229 0.12 ENSMUST00000049706.5
Fc receptor, IgE, high affinity I, alpha polypeptide
chr3_+_19957088 0.11 ENSMUST00000108328.1
ceruloplasmin
chr10_+_88146992 0.11 ENSMUST00000052355.7
nucleoporin 37
chr7_+_45785331 0.11 ENSMUST00000120005.1
ENSMUST00000123585.1
lemur tyrosine kinase 3
chr12_-_85288419 0.11 ENSMUST00000121930.1
acylphosphatase 1, erythrocyte (common) type
chr4_-_59783800 0.10 ENSMUST00000107526.1
ENSMUST00000095063.4
INTS3 and NABP interacting protein
chr17_-_35643684 0.10 ENSMUST00000095467.3
diffuse panbronchiolitis critical region 1 (human)
chr2_+_104027721 0.09 ENSMUST00000028603.3
F-box protein 3
chr2_+_104027823 0.09 ENSMUST00000111135.1
ENSMUST00000111136.1
ENSMUST00000102565.3
F-box protein 3
chr10_+_3872667 0.09 ENSMUST00000136671.1
ENSMUST00000042438.6
pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr3_+_19957240 0.08 ENSMUST00000108325.2
ceruloplasmin
chr8_+_4240105 0.08 ENSMUST00000110994.1
ENSMUST00000110995.1
mitogen-activated protein kinase kinase 7
chrX_+_135742686 0.08 ENSMUST00000096321.2
ENSMUST00000113144.1
ENSMUST00000113147.1
ENSMUST00000113145.1
armadillo repeat containing, X-linked 5
G protein-coupled receptor associated sorting protein 1
chr6_+_121183667 0.08 ENSMUST00000118234.1
ENSMUST00000088561.3
ENSMUST00000137432.1
ENSMUST00000120066.1
peroxisomal biogenesis factor 26
chr11_-_121519326 0.08 ENSMUST00000092298.5
zinc finger protein 750
chr13_+_94173992 0.08 ENSMUST00000121618.1
lipoma HMGIC fusion partner-like 2
chr3_+_90266507 0.08 ENSMUST00000098914.3
DENN/MADD domain containing 4B
chr17_-_87025353 0.07 ENSMUST00000024957.6
phosphatidylinositol glycan anchor biosynthesis, class F
chr11_-_49712674 0.07 ENSMUST00000020624.6
ENSMUST00000145353.1
CCR4-NOT transcription complex, subunit 6
chr2_-_85035487 0.07 ENSMUST00000028465.7
purinergic receptor P2X, ligand-gated ion channel, 3
chr14_-_19977249 0.06 ENSMUST00000160013.1
guanine nucleotide binding protein (G protein), gamma 2
chr17_+_50698525 0.06 ENSMUST00000061681.7
predicted gene 7334
chr10_+_97565436 0.06 ENSMUST00000038160.4
lumican
chr12_+_55598917 0.06 ENSMUST00000051857.3
insulinoma-associated 2
chr13_+_76579681 0.06 ENSMUST00000109589.2
multiple C2 domains, transmembrane 1
chr9_+_78051938 0.05 ENSMUST00000024104.7
glial cells missing homolog 1 (Drosophila)
chr2_+_152427639 0.04 ENSMUST00000128737.1
RIKEN cDNA 6820408C15 gene
chr16_-_76022266 0.04 ENSMUST00000114240.1
SAM domain, SH3 domain and nuclear localization signals, 1
chr5_+_146948640 0.04 ENSMUST00000146511.1
ENSMUST00000132102.1
general transcription factor III A
chr4_-_43653542 0.04 ENSMUST00000084646.4
sperm associated antigen 8
chr12_-_99393010 0.04 ENSMUST00000177451.1
forkhead box N3
chr12_+_38783503 0.04 ENSMUST00000159334.1
ets variant gene 1
chr5_+_139543889 0.03 ENSMUST00000174792.1
ENSMUST00000031523.8
UNC homeobox
chr14_+_55510445 0.03 ENSMUST00000165262.1
ENSMUST00000074225.4
copine VI
chr12_+_85288591 0.03 ENSMUST00000059341.4
zinc finger, C2HC-type containing 1C
chr17_-_27622785 0.03 ENSMUST00000176458.1
ENSMUST00000114886.1
nudix (nucleotide diphosphate linked moiety X)-type motif 3
chr16_+_33185045 0.02 ENSMUST00000039733.8
oxysterol binding protein-like 11
chr10_-_13868779 0.02 ENSMUST00000105534.3
androgen-induced 1
chr6_+_56956466 0.01 ENSMUST00000096612.3
vomeronasal 1 receptor 4
chr13_+_24943144 0.00 ENSMUST00000021773.5
glycosylphosphatidylinositol specific phospholipase D1
chr2_-_73625731 0.00 ENSMUST00000070579.6
chimerin (chimaerin) 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Irx5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:1990927 calcium ion regulated lysosome exocytosis(GO:1990927)
0.1 0.2 GO:0006114 glycerol biosynthetic process(GO:0006114) positive regulation of transcription from RNA polymerase II promoter in response to acidic pH(GO:0061402)
0.1 0.2 GO:0051344 L-ascorbic acid biosynthetic process(GO:0019853) negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344) positive regulation of calcium-transporting ATPase activity(GO:1901896) regulation of aminoacyl-tRNA ligase activity(GO:1903630)
0.0 0.3 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.1 GO:0048691 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) positive regulation of retinal ganglion cell axon guidance(GO:1902336)
0.0 0.5 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0 0.1 GO:0045401 positive regulation of interleukin-3 production(GO:0032752) interleukin-3 biosynthetic process(GO:0042223) granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0042253) regulation of interleukin-3 biosynthetic process(GO:0045399) positive regulation of interleukin-3 biosynthetic process(GO:0045401) regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045423) positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
0.0 0.3 GO:0014807 regulation of somitogenesis(GO:0014807)
0.0 0.5 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.2 GO:0015671 oxygen transport(GO:0015671)
0.0 0.3 GO:0008063 Toll signaling pathway(GO:0008063)
0.0 0.5 GO:0046688 response to copper ion(GO:0046688)
0.0 0.2 GO:2000653 regulation of genetic imprinting(GO:2000653)
0.0 0.1 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0 0.1 GO:2000327 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966) regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.0 0.1 GO:1904058 positive regulation of sensory perception of pain(GO:1904058)
0.0 0.1 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.0 0.1 GO:0045046 peroxisomal membrane transport(GO:0015919) protein import into peroxisome membrane(GO:0045046)
0.0 0.1 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 0.1 GO:0070876 SOSS complex(GO:0070876)
0.0 0.3 GO:0031045 dense core granule(GO:0031045)
0.0 0.3 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.2 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.1 GO:0031080 nuclear pore outer ring(GO:0031080)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1 0.5 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.1 GO:0019767 IgE receptor activity(GO:0019767)
0.0 0.6 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.1 GO:0003998 acylphosphatase activity(GO:0003998)
0.0 0.2 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.0 0.2 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 0.3 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.1 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.0 0.3 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.3 GO:0004385 guanylate kinase activity(GO:0004385)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.2 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.6 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.5 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.5 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters