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12D miR HR13_24

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Results for Nkx2-1

Z-value: 0.38

Motif logo

Transcription factors associated with Nkx2-1

Gene Symbol Gene ID Gene Info
ENSMUSG00000001496.9 NK2 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nkx2-1mm10_v2_chr12_-_56536895_565369370.392.4e-01Click!

Activity profile of Nkx2-1 motif

Sorted Z-values of Nkx2-1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr16_-_4523056 0.97 ENSMUST00000090500.3
ENSMUST00000023161.7
sarcalumenin
chr17_-_34628380 0.69 ENSMUST00000167097.2
palmitoyl-protein thioesterase 2
chr17_-_34628005 0.54 ENSMUST00000166040.2
palmitoyl-protein thioesterase 2
chr17_-_34627365 0.48 ENSMUST00000064953.8
ENSMUST00000170345.1
ENSMUST00000171121.2
ENSMUST00000168391.2
ENSMUST00000169067.2
palmitoyl-protein thioesterase 2
chr14_-_47411666 0.44 ENSMUST00000111778.3
discs, large (Drosophila) homolog-associated protein 5
chr12_+_91400990 0.42 ENSMUST00000021346.7
ENSMUST00000021343.6
thyroid stimulating hormone receptor
chr11_+_117849223 0.40 ENSMUST00000081387.4
baculoviral IAP repeat-containing 5
chr11_+_117849286 0.37 ENSMUST00000093906.4
baculoviral IAP repeat-containing 5
chr10_+_88091070 0.36 ENSMUST00000048621.7
pro-melanin-concentrating hormone
chr2_+_3770673 0.34 ENSMUST00000177037.1
family with sequence similarity 107, member B
chr16_+_48994185 0.33 ENSMUST00000117994.1
ENSMUST00000048374.5
RIKEN cDNA C330027C09 gene
chrX_+_49463926 0.28 ENSMUST00000130558.1
Rho GTPase activating protein 36
chr1_+_75450699 0.26 ENSMUST00000037708.9
acid-sensing (proton-gated) ion channel family member 4
chr17_-_45733843 0.26 ENSMUST00000178179.1
RIKEN cDNA 1600014C23 gene
chr14_+_37068042 0.25 ENSMUST00000057176.3
leucine-rich repeat, immunoglobulin-like and transmembrane domains 2
chrX_-_111463103 0.23 ENSMUST00000137712.2
ribosomal protein S6 kinase polypeptide 6
chr1_+_75450436 0.23 ENSMUST00000113577.1
acid-sensing (proton-gated) ion channel family member 4
chr3_+_68584154 0.22 ENSMUST00000182997.1
schwannomin interacting protein 1
chr2_-_121235689 0.22 ENSMUST00000142400.1
transformation related protein 53 binding protein 1
chr12_-_71136611 0.21 ENSMUST00000021486.8
ENSMUST00000166120.1
translocase of inner mitochondrial membrane 9
chr8_+_95703037 0.21 ENSMUST00000073139.7
ENSMUST00000080666.7
N-myc downstream regulated gene 4
chr2_+_19344820 0.20 ENSMUST00000150514.1
ENSMUST00000136456.1
RIKEN cDNA 4930447M23 gene
chr3_+_88532314 0.20 ENSMUST00000172699.1
mex3 homolog A (C. elegans)
chr1_+_135232045 0.19 ENSMUST00000110798.3
predicted gene 4204
chr11_+_85832551 0.18 ENSMUST00000000095.6
T-box 2
chr2_-_121085835 0.18 ENSMUST00000028721.7
transglutaminase 5
chr10_+_81176631 0.17 ENSMUST00000047864.9
eukaryotic translation elongation factor 2
chr1_-_14755966 0.17 ENSMUST00000027062.5
musculin
chr9_-_110624361 0.16 ENSMUST00000035069.9
neurotrophin receptor associated death domain
chrX_-_111463043 0.15 ENSMUST00000065976.5
ribosomal protein S6 kinase polypeptide 6
chr14_+_27238018 0.15 ENSMUST00000049206.5
Rho guanine nucleotide exchange factor (GEF) 3
chr4_-_9643638 0.15 ENSMUST00000108333.1
ENSMUST00000108334.1
ENSMUST00000108335.1
ENSMUST00000152526.1
ENSMUST00000103004.3
aspartate-beta-hydroxylase
chrX_+_98149666 0.15 ENSMUST00000052837.7
androgen receptor
chr19_+_44493472 0.14 ENSMUST00000041163.4
wingless related MMTV integration site 8b
chr2_+_19344317 0.14 ENSMUST00000141289.1
RIKEN cDNA 4930447M23 gene
chr4_-_109665249 0.14 ENSMUST00000063531.4
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr6_-_113434529 0.14 ENSMUST00000133348.1
cell death-inducing DFFA-like effector c
chr4_+_9269285 0.14 ENSMUST00000038841.7
clavesin 1
chr1_+_63176818 0.14 ENSMUST00000129339.1
eukaryotic translation elongation factor 1 beta 2
chr6_-_87851011 0.13 ENSMUST00000113617.1
cellular nucleic acid binding protein
chr11_-_120086790 0.13 ENSMUST00000106227.1
ENSMUST00000106229.1
ENSMUST00000180242.1
5-azacytidine induced gene 1
chr7_+_35397046 0.13 ENSMUST00000079414.5
centrosomal protein 89
chr10_+_22645011 0.13 ENSMUST00000042261.4
solute carrier family 2 (facilitated glucose transporter), member 12
chr17_-_32388885 0.12 ENSMUST00000087703.5
ENSMUST00000170603.1
widely-interspaced zinc finger motifs
chr6_-_101377342 0.11 ENSMUST00000151175.1
PDZ domain containing RING finger 3
chr1_+_74153981 0.11 ENSMUST00000027372.7
ENSMUST00000106899.2
chemokine (C-X-C motif) receptor 2
chr7_-_126200413 0.11 ENSMUST00000163959.1
exportin 6
chr7_-_126200397 0.11 ENSMUST00000009344.9
exportin 6
chr10_-_123196916 0.11 ENSMUST00000020334.7
ubiquitin specific peptidase 15
chr5_-_110779937 0.11 ENSMUST00000112426.1
pseudouridine synthase 1
chr7_+_128246953 0.11 ENSMUST00000167965.1
transforming growth factor beta 1 induced transcript 1
chr12_-_30911593 0.10 ENSMUST00000062740.7
ENSMUST00000074038.5
acid phosphatase 1, soluble
chr7_+_126272589 0.10 ENSMUST00000056028.9
SH3-binding kinase 1
chrX_+_73892102 0.10 ENSMUST00000033765.7
ENSMUST00000101470.2
ENSMUST00000114395.1
arginine vasopressin receptor 2
chr7_+_128246812 0.10 ENSMUST00000164710.1
ENSMUST00000070656.5
transforming growth factor beta 1 induced transcript 1
chr11_+_70030023 0.10 ENSMUST00000143920.2
discs, large homolog 4 (Drosophila)
chr5_+_128601106 0.09 ENSMUST00000117102.2
frizzled homolog 10 (Drosophila)
chr11_+_4267095 0.09 ENSMUST00000040750.3
leukemia inhibitory factor
chr11_+_63133068 0.09 ENSMUST00000108700.1
peripheral myelin protein 22
chr4_+_43727181 0.09 ENSMUST00000095109.3
histidine rich carboxyl terminus 1
chr1_-_120505084 0.09 ENSMUST00000027639.1
macrophage receptor with collagenous structure
chr9_-_71896047 0.08 ENSMUST00000184448.1
transcription factor 12
chr19_-_5468487 0.08 ENSMUST00000025844.4
cathepsin W
chr11_+_70029742 0.08 ENSMUST00000132597.2
discs, large homolog 4 (Drosophila)
chr11_+_70432627 0.08 ENSMUST00000084954.6
ENSMUST00000108568.3
ENSMUST00000079056.2
ENSMUST00000102564.4
ENSMUST00000124943.1
ENSMUST00000150076.1
ENSMUST00000102563.1
arrestin, beta 2
chr11_-_86257518 0.07 ENSMUST00000136469.1
ENSMUST00000018212.6
integrator complex subunit 2
chr3_+_37420273 0.07 ENSMUST00000029277.8
spermatogenesis associated 5
chr15_+_80234071 0.07 ENSMUST00000023048.4
ENSMUST00000166030.1
mitochondrial elongation factor 1
chr17_-_25570678 0.07 ENSMUST00000025003.3
ENSMUST00000173447.1
SRY-box containing gene 8
chr2_+_121506715 0.07 ENSMUST00000028676.5
WD repeat domain 76
chr2_+_10153563 0.06 ENSMUST00000026886.7
inter-alpha (globulin) inhibitor H5
chrX_-_48674478 0.06 ENSMUST00000053970.3
G-protein coupled receptor 119
chr11_-_86257553 0.06 ENSMUST00000132024.1
ENSMUST00000139285.1
integrator complex subunit 2
chr5_+_30105161 0.06 ENSMUST00000058045.4
GRB2 associated, regulator of MAPK1-like
chr9_+_56089962 0.05 ENSMUST00000059206.7
proline-serine-threonine phosphatase-interacting protein 1
chr3_+_135348029 0.05 ENSMUST00000159658.1
ENSMUST00000078568.5
ENSMUST00000160460.1
solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1
chrX_+_114474569 0.05 ENSMUST00000133447.1
kelch-like 4
chr4_-_41517326 0.05 ENSMUST00000030152.6
ENSMUST00000095126.4
RIKEN cDNA 1110017D15 gene
chr2_+_121506748 0.05 ENSMUST00000099473.3
ENSMUST00000110602.2
WD repeat domain 76
chr1_-_144545320 0.05 ENSMUST00000184189.1
regulator of G-protein signalling 21
chr11_+_70615836 0.05 ENSMUST00000180052.1
RIKEN cDNA 4930544D05 gene
chr2_+_80638798 0.05 ENSMUST00000028382.6
ENSMUST00000124377.1
nucleoporin 35
chr14_-_70524068 0.05 ENSMUST00000022692.3
surfactant associated protein C
chrX_-_73966329 0.05 ENSMUST00000114372.2
ENSMUST00000033761.6
host cell factor C1
chrX_+_114474312 0.05 ENSMUST00000113371.1
ENSMUST00000040504.5
kelch-like 4
chr2_-_57114970 0.05 ENSMUST00000028166.2
nuclear receptor subfamily 4, group A, member 2
chr2_+_80315461 0.05 ENSMUST00000028392.7
DnaJ (Hsp40) homolog, subfamily C, member 10
chr7_-_28372233 0.05 ENSMUST00000094644.4
pleckstrin homology domain containing, family G (with RhoGef domain) member 2
chr5_-_115341142 0.05 ENSMUST00000139167.1
glutamyl-tRNA(Gln) amidotransferase, subunit C homolog (bacterial)
chr1_-_54194048 0.04 ENSMUST00000120904.1
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
chr8_-_83442648 0.04 ENSMUST00000167525.1
short coiled-coil protein
chr7_-_29125142 0.04 ENSMUST00000179893.1
ENSMUST00000032813.9
ryanodine receptor 1, skeletal muscle
chr13_+_93304940 0.04 ENSMUST00000109497.1
ENSMUST00000109498.1
ENSMUST00000060490.4
ENSMUST00000109492.1
ENSMUST00000109496.1
ENSMUST00000109495.1
homer homolog 1 (Drosophila)
chr1_+_153900572 0.04 ENSMUST00000139476.1
glutamate-ammonia ligase (glutamine synthetase)
chr11_+_96292453 0.04 ENSMUST00000173432.1
homeobox B6
chr11_+_95666957 0.04 ENSMUST00000125172.1
ENSMUST00000036374.5
prohibitin
chr11_+_100622971 0.04 ENSMUST00000142993.1
NFKB inhibitor interacting Ras-like protein 2
chr7_-_28372597 0.03 ENSMUST00000144700.1
pleckstrin homology domain containing, family G (with RhoGef domain) member 2
chr6_-_82939676 0.03 ENSMUST00000000641.9
ENSMUST00000113982.1
sema domain, immunoglobulin domain (Ig), TM domain, and short cytoplasmic domain
chr17_+_36943025 0.03 ENSMUST00000173072.1
ring finger protein 39
chr11_+_80428598 0.03 ENSMUST00000173938.1
ENSMUST00000017572.7
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr2_-_120731503 0.03 ENSMUST00000110701.1
ENSMUST00000110700.1
congenital dyserythropoietic anemia, type I (human)
chr4_+_45203921 0.03 ENSMUST00000107804.1
FERM and PDZ domain containing 1
chrX_+_114474509 0.03 ENSMUST00000113370.2
kelch-like 4
chr2_+_69897220 0.03 ENSMUST00000055758.9
ENSMUST00000112251.2
ubiquitin protein ligase E3 component n-recognin 3
chr13_+_109903089 0.03 ENSMUST00000120664.1
phosphodiesterase 4D, cAMP specific
chr15_+_99702278 0.03 ENSMUST00000023759.4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
chr1_-_181842334 0.03 ENSMUST00000005003.6
lamin B receptor
chr11_+_115974930 0.03 ENSMUST00000106460.2
integrin beta 4
chr7_+_102225812 0.03 ENSMUST00000142873.1
post-GPI attachment to proteins 2
chr10_+_21690845 0.03 ENSMUST00000071008.3
predicted gene 5420
chrX_+_7762652 0.02 ENSMUST00000077680.3
ENSMUST00000079542.6
ENSMUST00000115679.1
ENSMUST00000137467.1
transcription factor E3
chr14_-_30915387 0.02 ENSMUST00000166622.1
inter-alpha trypsin inhibitor, heavy chain 3
chr12_+_85824633 0.02 ENSMUST00000177188.1
ENSMUST00000095536.3
ENSMUST00000110220.2
ENSMUST00000040179.7
tubulin tyrosine ligase-like family, member 5
chr16_+_44139821 0.02 ENSMUST00000159514.1
ENSMUST00000161326.1
ENSMUST00000063520.8
ENSMUST00000063542.7
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr2_-_103797617 0.02 ENSMUST00000028607.6
cell cycle associated protein 1
chrX_+_56963325 0.02 ENSMUST00000096431.3
G protein-coupled receptor 112
chr1_+_128103297 0.02 ENSMUST00000036288.4
R3H domain containing 1
chr4_+_89688196 0.02 ENSMUST00000052478.2
doublesex and mab-3 related transcription factor like family A1
chr2_-_158146385 0.02 ENSMUST00000103122.3
transglutaminase 2, C polypeptide
chr6_+_113472276 0.02 ENSMUST00000147316.1
interleukin 17 receptor C
chr4_-_141874879 0.01 ENSMUST00000036854.3
EF hand domain containing 2
chr13_+_55635002 0.01 ENSMUST00000172272.1
ENSMUST00000099479.3
DEAD (Asp-Glu-Ala-Asp) box polypeptide 46
chr19_-_60468304 0.01 ENSMUST00000051277.2
prolactin releasing hormone receptor
chr4_-_118490030 0.01 ENSMUST00000047421.5
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chr15_-_10470490 0.01 ENSMUST00000136591.1
DnaJ (Hsp40) homolog, subfamily C, member 21
chr9_+_75775355 0.01 ENSMUST00000012281.7
bone morphogenetic protein 5
chr19_-_8839181 0.01 ENSMUST00000096259.4
guanine nucleotide binding protein (G protein), gamma 3
chr15_+_89386827 0.01 ENSMUST00000166926.2
kelch domain containing 7B
chr1_+_75375271 0.01 ENSMUST00000087122.5
SPEG complex locus
chr7_+_35186370 0.00 ENSMUST00000135452.1
ENSMUST00000001854.5
solute carrier family 7 (cationic amino acid transporter, y+ system), member 10
chr3_-_95142346 0.00 ENSMUST00000013851.3
tumor necrosis factor, alpha-induced protein 8-like 2
chr7_+_30563838 0.00 ENSMUST00000163330.1
U2 small nuclear RNA auxiliary factor 1-like 4

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx2-1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 GO:0014874 response to stimulus involved in regulation of muscle adaptation(GO:0014874)
0.1 0.8 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.1 0.4 GO:1904587 response to glycoprotein(GO:1904587)
0.1 0.2 GO:0007521 muscle cell fate determination(GO:0007521)
0.1 0.4 GO:0042747 negative regulation of synaptic transmission, dopaminergic(GO:0032227) regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747)
0.0 0.1 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.0 0.1 GO:0060599 lateral sprouting involved in mammary gland duct morphogenesis(GO:0060599) tertiary branching involved in mammary gland duct morphogenesis(GO:0060748) positive regulation of epithelial cell proliferation involved in prostate gland development(GO:0060769)
0.0 0.2 GO:0014707 branchiomeric skeletal muscle development(GO:0014707)
0.0 0.2 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 0.1 GO:0072034 renal vesicle induction(GO:0072034)
0.0 0.2 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.1 GO:0033030 negative regulation of neutrophil apoptotic process(GO:0033030)
0.0 0.4 GO:2000381 negative regulation of mesoderm development(GO:2000381)
0.0 0.1 GO:0001992 regulation of systemic arterial blood pressure by vasopressin(GO:0001992)
0.0 0.2 GO:2000767 positive regulation of cytoplasmic translation(GO:2000767)
0.0 0.1 GO:0072108 positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis(GO:0072108)
0.0 0.1 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.0 0.1 GO:1990481 mRNA pseudouridine synthesis(GO:1990481)
0.0 0.0 GO:0019046 release from viral latency(GO:0019046)
0.0 0.2 GO:2001135 regulation of endocytic recycling(GO:2001135)
0.0 0.1 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.0 0.2 GO:0098953 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
0.0 0.2 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0 0.1 GO:0038030 non-canonical Wnt signaling pathway via MAPK cascade(GO:0038030) non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.0 0.0 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.0 0.1 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.0 0.0 GO:0051866 general adaptation syndrome(GO:0051866)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0031021 interphase microtubule organizing center(GO:0031021)
0.0 0.2 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 0.1 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.4 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.1 GO:0042629 mast cell granule(GO:0042629)
0.0 0.2 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.0 GO:0014802 terminal cisterna(GO:0014802)
0.0 1.0 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.0 0.2 GO:0005641 nuclear envelope lumen(GO:0005641)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.7 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 0.3 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.0 0.4 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.2 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.1 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.0 0.2 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.1 GO:0005146 leukemia inhibitory factor receptor binding(GO:0005146)
0.0 0.2 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.0 0.1 GO:0019958 C-X-C chemokine binding(GO:0019958)
0.0 1.0 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.2 GO:0031812 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.0 0.1 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 0.1 GO:0005000 vasopressin receptor activity(GO:0005000)
0.0 0.0 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.0 0.2 GO:0008097 5S rRNA binding(GO:0008097)
0.0 0.2 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.0 GO:0016211 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211)
0.0 0.4 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.0 GO:0031871 proteinase activated receptor binding(GO:0031871)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 PID AURORA A PATHWAY Aurora A signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors