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12D miR HR13_24

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Results for Smad3

Z-value: 1.46

Motif logo

Transcription factors associated with Smad3

Gene Symbol Gene ID Gene Info
ENSMUSG00000032402.6 SMAD family member 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Smad3mm10_v2_chr9_-_63757933_63757994-0.254.7e-01Click!

Activity profile of Smad3 motif

Sorted Z-values of Smad3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_100779074 4.22 ENSMUST00000110073.1
ENSMUST00000110070.1
RIKEN cDNA 9030617O03 gene
chr12_+_100779088 3.87 ENSMUST00000110069.1
RIKEN cDNA 9030617O03 gene
chr12_+_100779055 3.73 ENSMUST00000069782.4
RIKEN cDNA 9030617O03 gene
chr2_-_152831665 2.47 ENSMUST00000156688.1
ENSMUST00000007803.5
BCL2-like 1
chr2_-_152831112 2.32 ENSMUST00000128172.1
BCL2-like 1
chr13_+_21735055 2.24 ENSMUST00000087714.4
histone cluster 1, H4j
chr12_-_76795489 2.08 ENSMUST00000082431.3
glutathione peroxidase 2
chr13_+_23531044 1.91 ENSMUST00000102972.3
histone cluster 1, H4h
chr13_-_21750505 1.75 ENSMUST00000102983.1
histone cluster 1, H4k
chr13_-_21832194 1.72 ENSMUST00000102979.1
histone cluster 1, H4n
chr10_+_33905015 1.56 ENSMUST00000169670.1
radial spoke head 4 homolog A (Chlamydomonas)
chr13_-_23551648 1.40 ENSMUST00000102971.1
histone cluster 1, H4f
chr13_+_22043189 1.32 ENSMUST00000110452.1
histone cluster 1, H2bj
chr3_-_96263311 1.17 ENSMUST00000171473.1
histone cluster 2, H4
chr13_-_22042949 1.14 ENSMUST00000091741.4
histone cluster 1, H2ag
chr13_-_22035589 1.06 ENSMUST00000091742.4
histone cluster 1, H2ah
chr13_+_22035821 1.01 ENSMUST00000110455.2
histone cluster 1, H2bk
chr11_-_99986593 0.99 ENSMUST00000105050.2
keratin associated protein 16-1
chrX_+_143664365 0.96 ENSMUST00000126592.1
ENSMUST00000156449.1
ENSMUST00000155215.1
ENSMUST00000112865.1
p21 protein (Cdc42/Rac)-activated kinase 3
chrX_+_143664290 0.94 ENSMUST00000112868.1
p21 protein (Cdc42/Rac)-activated kinase 3
chr11_+_58954675 0.91 ENSMUST00000108817.3
ENSMUST00000047697.5
histone cluster 3, H2a
tripartite motif-containing 17
chr13_+_21833736 0.90 ENSMUST00000180288.1
ENSMUST00000110467.1
histone cluster 1 H2br
chr6_+_116650674 0.83 ENSMUST00000067354.5
ENSMUST00000178241.1
RIKEN cDNA 8430408G22 gene
chr7_-_44236098 0.83 ENSMUST00000037220.4
RIKEN cDNA 1700028J19 gene
chr13_+_23581563 0.80 ENSMUST00000102968.1
histone cluster 1, H4d
chr13_-_21833575 0.74 ENSMUST00000081342.5
histone cluster 1, H2ap
chr13_+_23533869 0.70 ENSMUST00000073261.2
histone cluster 1, H2af
chr7_-_100964371 0.70 ENSMUST00000060174.4
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr13_+_21787461 0.69 ENSMUST00000110473.2
ENSMUST00000102982.1
histone cluster 1, H2bp
chr13_-_21810190 0.69 ENSMUST00000110469.1
ENSMUST00000091749.2
histone cluster 1, H2bq
chr13_-_23571151 0.67 ENSMUST00000102969.3
histone cluster 1, H2ae
chr5_-_116422858 0.67 ENSMUST00000036991.4
heat shock protein 8
chr13_+_21810428 0.62 ENSMUST00000091745.5
histone cluster 1, H2ao
chr6_+_136808248 0.62 ENSMUST00000074556.4
H2A histone family, member J
chr5_-_72504202 0.61 ENSMUST00000005352.3
corin
chr13_+_23746734 0.58 ENSMUST00000099703.2
histone cluster 1, H2bb
chr13_+_23571382 0.51 ENSMUST00000079251.5
histone cluster 1, H2bg
chrX_+_153832225 0.51 ENSMUST00000148708.1
ENSMUST00000123264.1
ENSMUST00000049999.8
spindlin family, member 2C
chr17_+_56628118 0.50 ENSMUST00000112979.2
catsper channel auxiliary subunit delta
chr15_+_81936911 0.49 ENSMUST00000135663.1
cold shock domain containing C2, RNA binding
chr13_+_23684192 0.49 ENSMUST00000018246.4
histone cluster 1, H2bc
chr14_-_79868398 0.46 ENSMUST00000179430.1
predicted gene 10845
chr13_-_21787218 0.46 ENSMUST00000091751.2
histone cluster 1, H2an
chr14_+_119138415 0.45 ENSMUST00000065904.3
heparan sulfate 6-O-sulfotransferase 3
chrX_-_20291728 0.44 ENSMUST00000115393.2
solute carrier family 9 (sodium/hydrogen exchanger), member 7
chr1_-_126492900 0.44 ENSMUST00000161954.1
NCK-associated protein 5
chr13_-_23683941 0.43 ENSMUST00000171127.1
histone cluster 1, H2ac
chrX_-_20291776 0.42 ENSMUST00000072451.4
solute carrier family 9 (sodium/hydrogen exchanger), member 7
chr1_-_134235420 0.42 ENSMUST00000038191.6
ENSMUST00000086465.4
adenosine A1 receptor
chrX_-_150814265 0.41 ENSMUST00000026302.6
ENSMUST00000129768.1
ENSMUST00000112699.2
melanoma antigen, family D, 2
chr2_-_148408146 0.40 ENSMUST00000099270.3
thrombomodulin
chr1_-_75210732 0.38 ENSMUST00000113623.1
galactosidase, beta 1-like
chr5_+_92392585 0.36 ENSMUST00000126281.1
ADP-ribosyltransferase 3
chr1_+_60909148 0.35 ENSMUST00000097720.3
cytotoxic T-lymphocyte-associated protein 4
chrX_-_144688180 0.31 ENSMUST00000040184.3
transient receptor potential cation channel, subfamily C, member 5
chr9_+_54286479 0.30 ENSMUST00000056740.5
gliomedin
chr7_-_127588595 0.30 ENSMUST00000072155.3
predicted gene 166
chr14_+_32028989 0.30 ENSMUST00000022460.4
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15
chr1_+_131688766 0.28 ENSMUST00000129905.1
RIKEN cDNA 5430435G22 gene
chr4_+_140986873 0.25 ENSMUST00000168047.1
ENSMUST00000037055.7
ENSMUST00000127833.2
ATPase type 13A2
chr14_+_57424054 0.25 ENSMUST00000122063.1
intraflagellar transport 88
chr7_-_119479249 0.24 ENSMUST00000033263.4
uromodulin
chr6_-_129533267 0.24 ENSMUST00000181594.1
RIKEN cDNA 1700101I11 gene
chr1_-_126492683 0.23 ENSMUST00000162877.1
NCK-associated protein 5
chr4_+_95557494 0.23 ENSMUST00000079223.4
ENSMUST00000177394.1
FGGY carbohydrate kinase domain containing
chr15_-_103252810 0.23 ENSMUST00000154510.1
nuclear factor, erythroid derived 2
chr8_-_72435043 0.23 ENSMUST00000109974.1
calreticulin 3
chr5_+_114774677 0.23 ENSMUST00000102578.4
ankyrin repeat domain 13a
chr10_+_79854658 0.22 ENSMUST00000171599.1
ENSMUST00000095457.4
polypyrimidine tract binding protein 1
chr2_+_178193075 0.22 ENSMUST00000103065.1
phosphatase and actin regulator 3
chr6_+_120093348 0.22 ENSMUST00000112711.2
ninjurin 2
chr3_-_107760221 0.22 ENSMUST00000153114.1
ENSMUST00000118593.1
ENSMUST00000120243.1
colony stimulating factor 1 (macrophage)
chr7_+_44384803 0.21 ENSMUST00000120262.1
synaptotagmin III
chr2_-_30194112 0.21 ENSMUST00000113659.1
ENSMUST00000113660.1
cysteine conjugate-beta lyase 1
chr9_+_44072196 0.20 ENSMUST00000176671.1
ubiquitin specific peptidase 2
chr13_-_96435952 0.19 ENSMUST00000181761.1
ankyrin repeat and death domain containing 1B
chr10_+_79854618 0.19 ENSMUST00000165704.1
polypyrimidine tract binding protein 1
chr5_+_145204523 0.18 ENSMUST00000085671.3
ENSMUST00000031601.7
zinc finger with KRAB and SCAN domains 5
chr19_-_23448322 0.17 ENSMUST00000036069.6
MAM domain containing 2
chr1_+_60908993 0.17 ENSMUST00000027164.2
cytotoxic T-lymphocyte-associated protein 4
chr16_-_45158183 0.17 ENSMUST00000114600.1
solute carrier family 35, member A5
chr5_+_136038496 0.16 ENSMUST00000062606.6
uroplakin 3B
chr11_-_26591729 0.16 ENSMUST00000109504.1
vaccinia related kinase 2
chr7_+_137437591 0.16 ENSMUST00000064404.6
glutaredoxin 3
chr11_-_116110211 0.14 ENSMUST00000106441.1
ENSMUST00000021120.5
tripartite motif-containing 47
chr10_-_118868903 0.13 ENSMUST00000004281.8
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
chr9_+_109038565 0.13 ENSMUST00000112059.3
ENSMUST00000026737.5
shisa homolog 5 (Xenopus laevis)
chr2_-_132945906 0.13 ENSMUST00000038280.4
fermitin family homolog 1 (Drosophila)
chr7_+_123462274 0.12 ENSMUST00000033023.3
aquaporin 8
chr17_-_31277327 0.12 ENSMUST00000024832.7
radial spoke head 1 homolog (Chlamydomonas)
chr4_+_45018583 0.12 ENSMUST00000133157.1
ENSMUST00000029999.8
ENSMUST00000107814.3
polymerase (RNA) I polypeptide E
chr15_-_101562889 0.12 ENSMUST00000023714.4
RIKEN cDNA 4732456N10 gene
chr9_+_13621646 0.11 ENSMUST00000034401.8
mastermind like 2 (Drosophila)
chr9_+_21196705 0.11 ENSMUST00000003395.9
phosphodiesterase 4A, cAMP specific
chr11_+_73240310 0.10 ENSMUST00000138853.1
transient receptor potential cation channel, subfamily V, member 1
chr6_+_129533183 0.10 ENSMUST00000032264.6
gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1
chr11_-_103344651 0.10 ENSMUST00000041385.7
Rho GTPase activating protein 27
chr17_-_27623263 0.09 ENSMUST00000062397.6
ENSMUST00000176876.1
nudix (nucleotide diphosphate linked moiety X)-type motif 3
chr17_-_27623441 0.09 ENSMUST00000025050.5
nudix (nucleotide diphosphate linked moiety X)-type motif 3
chr7_-_104369782 0.08 ENSMUST00000164410.1
tripartite motif-containing 30B
chr7_-_24316590 0.08 ENSMUST00000108436.1
ENSMUST00000032673.8
zinc finger protein 94
chr2_-_104257400 0.07 ENSMUST00000141159.1
RIKEN cDNA D430041D05 gene
chr9_+_108490676 0.07 ENSMUST00000178075.1
ENSMUST00000085044.7
ENSMUST00000166103.2
ENSMUST00000006854.7
ubiquitin specific peptidase 19
chr19_-_47919269 0.07 ENSMUST00000095998.5
inositol 1,4,5-triphosphate receptor interacting protein
chr19_+_55898553 0.06 ENSMUST00000148666.1
transcription factor 7 like 2, T cell specific, HMG box
chr2_-_17460610 0.06 ENSMUST00000145492.1
nebulette
chr11_+_49523721 0.05 ENSMUST00000077143.4
olfactory receptor 1383
chr1_+_165485168 0.05 ENSMUST00000111440.1
ENSMUST00000027852.8
ENSMUST00000111439.1
adenylate cyclase 10
chr7_-_45052865 0.04 ENSMUST00000057293.6
proline rich 12
chr1_+_146497614 0.04 ENSMUST00000132847.1
ENSMUST00000166814.1
bone morphogenetic protein/retinoic acid inducible neural specific 3
chr9_-_20879718 0.04 ENSMUST00000043726.6
angiopoietin-like 6
chr19_+_5740885 0.03 ENSMUST00000081496.5
latent transforming growth factor beta binding protein 3
chr7_+_127588698 0.02 ENSMUST00000033088.6
ring finger protein 40
chr7_-_81454751 0.02 ENSMUST00000098331.3
ENSMUST00000178892.1
cytoplasmic polyadenylation element binding protein 1
chr14_+_20348159 0.02 ENSMUST00000090503.4
ENSMUST00000090499.5
ENSMUST00000037698.5
ENSMUST00000051915.6
family with sequence similarity 149, member B
chr4_+_130055010 0.01 ENSMUST00000123617.1
collagen, type XVI, alpha 1
chr18_+_60526194 0.01 ENSMUST00000025505.5
dynactin 4
chr1_-_23909687 0.01 ENSMUST00000129254.1
small ArfGAP 1
chr2_-_127143410 0.01 ENSMUST00000132773.1
inositol 1,4,5-triphosphate receptor interacting protein-like 1
chr11_+_46436925 0.01 ENSMUST00000152119.1
ENSMUST00000140027.1
ENSMUST00000020665.6
ENSMUST00000170928.1
ENSMUST00000109231.1
ENSMUST00000109232.3
ENSMUST00000128940.1
mediator complex subunit 7

Network of associatons between targets according to the STRING database.

First level regulatory network of Smad3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.8 GO:0046898 response to cycloheximide(GO:0046898)
0.5 11.0 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.2 0.6 GO:0003050 regulation of systemic arterial blood pressure by atrial natriuretic peptide(GO:0003050)
0.1 0.4 GO:0032242 positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242)
0.1 2.1 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.1 2.0 GO:0002227 innate immune response in mucosa(GO:0002227)
0.1 0.3 GO:1902630 regulation of membrane hyperpolarization(GO:1902630)
0.1 0.7 GO:0030321 transepithelial chloride transport(GO:0030321)
0.1 0.5 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)
0.1 0.2 GO:0007290 spermatid nucleus elongation(GO:0007290)
0.1 0.2 GO:0072221 distal convoluted tubule development(GO:0072025) metanephric distal convoluted tubule development(GO:0072221) metanephric distal tubule development(GO:0072235)
0.1 0.5 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1 0.2 GO:1902226 positive regulation of odontogenesis of dentin-containing tooth(GO:0042488) regulation of macrophage colony-stimulating factor signaling pathway(GO:1902226) regulation of response to macrophage colony-stimulating factor(GO:1903969) regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903972)
0.1 1.9 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.1 0.4 GO:0070294 renal sodium ion absorption(GO:0070294)
0.1 0.9 GO:0070914 UV-damage excision repair(GO:0070914)
0.1 0.2 GO:0018197 peptidyl-aspartic acid modification(GO:0018197)
0.1 0.2 GO:0071544 diphosphoinositol polyphosphate catabolic process(GO:0071544)
0.1 0.9 GO:0097369 sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 5.7 GO:0006342 chromatin silencing(GO:0006342)
0.0 0.1 GO:0001180 transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript(GO:0001180)
0.0 0.3 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.4 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.0 0.1 GO:2001201 regulation of transforming growth factor-beta secretion(GO:2001201)
0.0 1.7 GO:0035082 axoneme assembly(GO:0035082)
0.0 0.2 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 2.6 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.5 GO:0048240 sperm capacitation(GO:0048240)
0.0 0.2 GO:0034242 negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
0.0 0.2 GO:2000659 regulation of interleukin-1-mediated signaling pathway(GO:2000659)
0.0 0.1 GO:0015722 canalicular bile acid transport(GO:0015722)
0.0 0.1 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.0 0.2 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.2 GO:0019321 pentose metabolic process(GO:0019321)
0.0 0.3 GO:0048642 negative regulation of skeletal muscle tissue development(GO:0048642)
0.0 0.0 GO:1902460 transforming growth factor beta activation(GO:0036363) regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.0 0.1 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 4.8 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.3 10.2 GO:0000788 nuclear nucleosome(GO:0000788)
0.2 6.4 GO:0000786 nucleosome(GO:0000786)
0.1 0.2 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.1 0.2 GO:0031310 integral component of vacuolar membrane(GO:0031166) intrinsic component of vacuolar membrane(GO:0031310)
0.1 0.5 GO:0036128 CatSper complex(GO:0036128)
0.0 0.1 GO:0046691 intracellular canaliculus(GO:0046691)
0.0 0.2 GO:0002081 outer acrosomal membrane(GO:0002081)
0.0 1.0 GO:0045095 keratin filament(GO:0045095)
0.0 0.9 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.4 GO:0032279 asymmetric synapse(GO:0032279)
0.0 0.4 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.5 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 0.1 GO:0001520 outer dense fiber(GO:0001520)
0.0 1.6 GO:0005930 axoneme(GO:0005930)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.8 GO:0051434 BH3 domain binding(GO:0051434)
0.2 0.7 GO:0015065 uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.1 0.5 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.1 1.9 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 2.1 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 0.4 GO:0004565 beta-galactosidase activity(GO:0004565)
0.1 0.2 GO:0019150 D-ribulokinase activity(GO:0019150)
0.1 0.2 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.1 0.4 GO:0001069 regulatory region RNA binding(GO:0001069)
0.1 0.9 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.1 0.4 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.0 10.8 GO:0042393 histone binding(GO:0042393)
0.0 0.2 GO:0019864 IgG binding(GO:0019864)
0.0 0.3 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 0.2 GO:0008486 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.0 0.4 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.0 0.3 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.1 GO:0001179 RNA polymerase I transcription factor binding(GO:0001179)
0.0 0.3 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.6 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.2 GO:0070300 calcium-transporting ATPase activity(GO:0005388) phosphatidic acid binding(GO:0070300)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.8 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.9 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 1.5 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 13.1 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.2 4.8 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.1 1.1 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.0 0.4 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.3 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.5 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.0 0.2 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.5 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.1 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins