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12D miR HR13_24

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Results for Rest

Z-value: 1.10

Motif logo

Transcription factors associated with Rest

Gene Symbol Gene ID Gene Info
ENSMUSG00000029249.9 RE1-silencing transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Restmm10_v2_chr5_+_77266196_77266232-0.441.7e-01Click!

Activity profile of Rest motif

Sorted Z-values of Rest motif

Promoter Log-likelihood Transcript Gene Gene Info
chr16_-_23890805 5.19 ENSMUST00000004480.3
somatostatin
chr12_-_84698769 2.42 ENSMUST00000095550.2
synapse differentiation inducing 1 like
chr19_+_42255704 1.96 ENSMUST00000087123.5
golgi autoantigen, golgin subfamily a, 7B
chr10_+_5639210 1.85 ENSMUST00000019906.4
vasoactive intestinal polypeptide
chr17_+_69439326 1.66 ENSMUST00000169935.1
RIKEN cDNA A330050F15 gene
chrX_-_73869804 1.20 ENSMUST00000066576.5
ENSMUST00000114430.1
L1 cell adhesion molecule
chr17_-_91092715 1.14 ENSMUST00000160800.2
ENSMUST00000159778.1
ENSMUST00000160844.3
neurexin I
chr1_-_84696182 1.13 ENSMUST00000049126.6
delta/notch-like EGF-related receptor
chr3_+_114904062 1.10 ENSMUST00000081752.6
olfactomedin 3
chr13_-_56895737 1.01 ENSMUST00000022023.6
ENSMUST00000109871.1
transient receptor potential cation channel, subfamily C, member 7
chr19_+_22139028 0.97 ENSMUST00000099569.2
ENSMUST00000087576.4
ENSMUST00000074770.5
transient receptor potential cation channel, subfamily M, member 3
chr8_+_84946987 0.92 ENSMUST00000067472.7
ENSMUST00000109740.2
retbindin
chr9_+_104569754 0.92 ENSMUST00000077190.6
copine IV
chr9_+_104569671 0.87 ENSMUST00000057742.8
copine IV
chr9_+_59578192 0.84 ENSMUST00000118549.1
ENSMUST00000034840.3
CUGBP, Elav-like family member 6
chr17_+_28575718 0.77 ENSMUST00000080780.6
lipoma HMGIC fusion partner-like 5
chr5_+_137030275 0.77 ENSMUST00000041543.8
VGF nerve growth factor inducible
chr5_-_116591811 0.75 ENSMUST00000076124.5
serine/arginine repetitive matrix 4
chr15_-_76521902 0.73 ENSMUST00000164703.1
ENSMUST00000096365.3
scratch homolog 1, zinc finger protein (Drosophila)
chr13_-_99900645 0.62 ENSMUST00000022150.6
CART prepropeptide
chr11_-_55607733 0.53 ENSMUST00000108853.1
ENSMUST00000075603.4
glycine receptor, alpha 1 subunit
chr15_+_101473472 0.52 ENSMUST00000088049.3
keratin 86
chr2_+_22622183 0.52 ENSMUST00000028123.3
glutamic acid decarboxylase 2
chr12_+_102554966 0.52 ENSMUST00000021610.5
chromogranin A
chr15_-_75747922 0.50 ENSMUST00000062002.4
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian)
chr1_+_34579693 0.48 ENSMUST00000052670.8
APC membrane recruitment 3
chr19_-_8929323 0.46 ENSMUST00000096242.3
rod outer segment membrane protein 1
chr1_-_92902883 0.46 ENSMUST00000160548.1
ENSMUST00000112998.1
ankyrin repeat and MYND domain containing 1
chr7_-_27396542 0.44 ENSMUST00000108363.1
spectrin beta, non-erythrocytic 4
chr19_-_45046614 0.43 ENSMUST00000145391.1
PDZ domain containing 7
chr4_+_15881255 0.42 ENSMUST00000029876.1
calbindin 1
chr2_-_28916668 0.42 ENSMUST00000113847.1
BarH-like 1 (Drosophila)
chr2_-_28916412 0.41 ENSMUST00000050776.2
ENSMUST00000113849.1
BarH-like 1 (Drosophila)
chr11_-_55608189 0.40 ENSMUST00000102716.3
glycine receptor, alpha 1 subunit
chr9_-_63146980 0.39 ENSMUST00000055281.7
ENSMUST00000119146.1
SKI family transcriptional corepressor 1
chr11_-_117873433 0.38 ENSMUST00000033230.7
threonine aldolase 1
chr1_+_81077204 0.36 ENSMUST00000123720.1
neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2
chr1_+_81077274 0.36 ENSMUST00000068275.5
ENSMUST00000113494.2
neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2
chr17_-_72603709 0.35 ENSMUST00000086639.4
anaplastic lymphoma kinase
chr16_+_30065333 0.34 ENSMUST00000023171.7
hairy and enhancer of split 1 (Drosophila)
chr2_+_132781278 0.32 ENSMUST00000028826.3
chromogranin B
chr17_-_25240112 0.31 ENSMUST00000038973.6
ENSMUST00000115154.4
N-acetylglucosamine-1-phosphotransferase, gamma subunit
chr15_-_11037968 0.31 ENSMUST00000058007.5
relaxin family peptide receptor 3
chr5_+_27841947 0.30 ENSMUST00000036227.5
5-hydroxytryptamine (serotonin) receptor 5A
chr1_+_70725902 0.29 ENSMUST00000161937.1
ENSMUST00000162182.1
von Willebrand factor C domain-containing protein 2-like
chr6_-_121473630 0.29 ENSMUST00000046373.5
IQ motif and Sec7 domain 3
chr1_+_70725715 0.29 ENSMUST00000053922.5
von Willebrand factor C domain-containing protein 2-like
chr13_+_54371340 0.28 ENSMUST00000026985.8
complexin 2
chr13_-_105054895 0.28 ENSMUST00000063551.5
regulator of G-protein signalling 7 binding protein
chr5_-_121009510 0.27 ENSMUST00000079204.5
rabphilin 3A
chr12_+_31390843 0.26 ENSMUST00000167432.1
solute carrier family 26, member 3
chr11_+_74619594 0.26 ENSMUST00000100866.2
RIKEN cDNA E130309D14 gene
chr10_+_6788809 0.24 ENSMUST00000105611.1
ENSMUST00000052751.7
ENSMUST00000135502.1
ENSMUST00000105605.1
ENSMUST00000154906.1
ENSMUST00000092731.4
ENSMUST00000000783.6
ENSMUST00000078634.5
ENSMUST00000105602.1
ENSMUST00000105604.1
ENSMUST00000105603.1
opioid receptor, mu 1
chr11_-_3774706 0.21 ENSMUST00000155197.1
oxysterol binding protein 2
chr3_-_89764581 0.21 ENSMUST00000029562.3
cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)
chr11_+_80477015 0.21 ENSMUST00000053413.10
ENSMUST00000147694.1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr7_-_81493883 0.19 ENSMUST00000082090.7
adaptor-related protein complex 3, beta 2 subunit
chr11_+_69914179 0.18 ENSMUST00000057884.5
G protein pathway suppressor 2
chr7_+_49910112 0.17 ENSMUST00000056442.5
solute carrier family 6 (neurotransmitter transporter, glycine), member 5
chr1_-_193035651 0.17 ENSMUST00000016344.7
synaptotagmin XIV
chr7_-_3616133 0.16 ENSMUST00000039507.8
ENSMUST00000108645.1
ENSMUST00000148012.1
osteoclast associated receptor
chr17_-_83631892 0.15 ENSMUST00000051482.1
potassium voltage-gated channel, subfamily G, member 3
chrX_+_7638674 0.14 ENSMUST00000128890.1
synaptophysin
chr2_-_122313644 0.13 ENSMUST00000147788.1
ENSMUST00000154412.1
ENSMUST00000110537.1
ENSMUST00000148417.1
dual oxidase maturation factor 1
chr2_-_92401237 0.13 ENSMUST00000050312.2
mitogen-activated protein kinase 8 interacting protein 1
chr8_+_69088646 0.12 ENSMUST00000006435.7
ATPase, H+ transporting, lysosomal V1 subunit B2
chr15_-_76722161 0.12 ENSMUST00000049956.4
leucine rich repeat containing 24
chrX_-_20920911 0.12 ENSMUST00000081893.6
ENSMUST00000115345.1
synapsin I
chr2_-_181314500 0.12 ENSMUST00000103045.3
stathmin-like 3
chr8_+_55940453 0.12 ENSMUST00000000275.7
glycine receptor, alpha 3 subunit
chr10_+_90829538 0.09 ENSMUST00000179694.2
ankyrin repeat and sterile alpha motif domain containing 1B
chr4_+_130055010 0.09 ENSMUST00000123617.1
collagen, type XVI, alpha 1
chr7_-_81493725 0.08 ENSMUST00000119121.1
adaptor-related protein complex 3, beta 2 subunit
chr9_+_40801235 0.08 ENSMUST00000117870.1
ENSMUST00000117557.1
heat shock protein 8
chr10_-_115587739 0.06 ENSMUST00000020350.8
leucine rich repeat containing G protein coupled receptor 5
chr5_+_38260372 0.06 ENSMUST00000119047.1
transmembrane protein 128
chr4_+_101550411 0.04 ENSMUST00000094953.4
ENSMUST00000106933.1
DnaJ (Hsp40) homolog, subfamily C, member 6
chr10_+_90829409 0.04 ENSMUST00000182202.1
ENSMUST00000182966.1
ankyrin repeat and sterile alpha motif domain containing 1B
chr4_-_153482768 0.03 ENSMUST00000105646.2
adherens junction associated protein 1
chr6_+_113282302 0.03 ENSMUST00000041203.5
copine family member IX
chr12_+_119945957 0.02 ENSMUST00000058644.8
transmembrane protein 196
chr2_+_157456917 0.02 ENSMUST00000109529.1
Rous sarcoma oncogene
chr10_-_41072279 0.02 ENSMUST00000061796.6
G protein-coupled receptor 6

Network of associatons between targets according to the STRING database.

First level regulatory network of Rest

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 GO:0010578 regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579)
0.3 1.1 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.2 0.6 GO:0070093 negative regulation of glucagon secretion(GO:0070093)
0.2 2.0 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.2 0.5 GO:1901079 positive regulation of relaxation of muscle(GO:1901079)
0.2 0.9 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.1 0.4 GO:0072221 distal convoluted tubule development(GO:0072025) metanephric distal convoluted tubule development(GO:0072221) metanephric distal tubule development(GO:0072235)
0.1 0.3 GO:0036269 swimming behavior(GO:0036269)
0.1 0.3 GO:2000978 trochlear nerve development(GO:0021558) negative regulation of forebrain neuron differentiation(GO:2000978)
0.1 0.3 GO:0016256 N-glycan processing to lysosome(GO:0016256)
0.1 0.5 GO:0006538 glutamate catabolic process(GO:0006538)
0.1 1.2 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.1 0.4 GO:0006566 threonine metabolic process(GO:0006566)
0.1 0.2 GO:0032097 adenylate cyclase-inhibiting opioid receptor signaling pathway(GO:0031635) positive regulation of response to food(GO:0032097) positive regulation of appetite(GO:0032100)
0.1 1.1 GO:0007220 Notch receptor processing(GO:0007220)
0.1 0.1 GO:2000474 regulation of opioid receptor signaling pathway(GO:2000474)
0.1 0.2 GO:0060084 synaptic transmission involved in micturition(GO:0060084)
0.1 0.8 GO:0043084 penile erection(GO:0043084)
0.1 0.4 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.1 1.2 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910) auditory receptor cell stereocilium organization(GO:0060088)
0.0 0.3 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.0 0.1 GO:2000609 regulation of thyroid hormone generation(GO:2000609)
0.0 0.2 GO:0036233 glycine import(GO:0036233)
0.0 1.0 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.2 GO:0007158 neuron cell-cell adhesion(GO:0007158)
0.0 0.8 GO:0071625 vocalization behavior(GO:0071625)
0.0 0.1 GO:0097212 protein targeting to vacuole involved in autophagy(GO:0071211) lysosomal membrane organization(GO:0097212) positive regulation of protein folding(GO:1903334)
0.0 0.5 GO:0007263 nitric oxide mediated signal transduction(GO:0007263)
0.0 0.1 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.1 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.0 1.6 GO:0001754 eye photoreceptor cell differentiation(GO:0001754)
0.0 0.3 GO:0045852 pH elevation(GO:0045852) intracellular pH elevation(GO:0051454)
0.0 0.3 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
0.0 0.7 GO:2001222 regulation of neuron migration(GO:2001222)
0.0 0.8 GO:0030901 midbrain development(GO:0030901)
0.0 1.0 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.0 0.8 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.1 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.0 0.3 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.0 0.1 GO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.0 0.0 GO:0030860 regulation of polarized epithelial cell differentiation(GO:0030860)
0.0 0.1 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0033165 interphotoreceptor matrix(GO:0033165)
0.2 2.0 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.1 0.4 GO:1990696 USH2 complex(GO:1990696)
0.1 0.5 GO:0042583 chromaffin granule(GO:0042583)
0.1 1.3 GO:0044294 dendritic growth cone(GO:0044294)
0.1 2.9 GO:0060077 inhibitory synapse(GO:0060077)
0.1 0.3 GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.1 0.2 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.1 0.4 GO:0008091 spectrin(GO:0008091)
0.0 0.8 GO:0032426 stereocilium tip(GO:0032426)
0.0 0.5 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 1.0 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.3 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.0 0.1 GO:0099522 region of cytosol(GO:0099522) postsynaptic cytosol(GO:0099524)
0.0 1.0 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.5 GO:0045095 keratin filament(GO:0045095)
0.0 0.2 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.3 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.1 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0030977 taurine binding(GO:0030977)
0.2 1.2 GO:0033691 sialic acid binding(GO:0033691)
0.1 0.4 GO:0008732 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.1 0.3 GO:0071820 N-box binding(GO:0071820)
0.1 1.1 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 8.0 GO:0005179 hormone activity(GO:0005179)
0.1 0.3 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.1 1.0 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 0.3 GO:0004966 galanin receptor activity(GO:0004966)
0.1 0.5 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.1 2.0 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 0.4 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.2 GO:0004985 melanocortin receptor activity(GO:0004977) opioid receptor activity(GO:0004985)
0.0 0.3 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.0 1.1 GO:0005112 Notch binding(GO:0005112)
0.0 0.1 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.1 GO:0031686 A1 adenosine receptor binding(GO:0031686)
0.0 0.3 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993) serotonin binding(GO:0051378)
0.0 0.3 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.2 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848) acetylcholine binding(GO:0042166)
0.0 0.2 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.0 0.3 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.4 GO:0030506 ankyrin binding(GO:0030506)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 1.1 PID NOTCH PATHWAY Notch signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 1.1 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 5.3 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.8 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 1.2 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 1.1 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.3 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 0.6 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.1 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.2 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.8 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 0.2 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.2 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling