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12D miR HR13_24

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Results for Hmx3

Z-value: 0.74

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Transcription factors associated with Hmx3

Gene Symbol Gene ID Gene Info
ENSMUSG00000040148.5 H6 homeobox 3

Activity profile of Hmx3 motif

Sorted Z-values of Hmx3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_158814469 2.01 ENSMUST00000161589.2
pappalysin 2
chr15_+_9436028 1.94 ENSMUST00000042360.3
calcyphosine-like
chr13_-_92131494 1.38 ENSMUST00000099326.3
ENSMUST00000146492.1
RAS protein-specific guanine nucleotide-releasing factor 2
chr9_+_21955747 1.11 ENSMUST00000053583.5
SWIM type zinc finger 7 associated protein 1
chr2_-_103283760 0.88 ENSMUST00000111174.1
ets homologous factor
chr17_-_35046539 0.87 ENSMUST00000007250.7
mutS homolog 5 (E. coli)
chr1_+_110099295 0.83 ENSMUST00000134301.1
cadherin 7, type 2
chrX_+_139563316 0.63 ENSMUST00000113027.1
ring finger protein 128
chr19_-_56822161 0.63 ENSMUST00000118592.1
RIKEN cDNA A630007B06 gene
chr14_-_55560340 0.62 ENSMUST00000066106.3
RIKEN cDNA A730061H03 gene
chr3_+_3634145 0.55 ENSMUST00000108394.1
hepatocyte nuclear factor 4, gamma
chr14_+_54464141 0.52 ENSMUST00000022782.8
low-density lipoprotein receptor-related protein 10
chr2_+_57997884 0.44 ENSMUST00000112616.1
ENSMUST00000166729.1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5
chr4_-_45532470 0.42 ENSMUST00000147448.1
src homology 2 domain-containing transforming protein B
chr11_+_69838514 0.41 ENSMUST00000133967.1
ENSMUST00000094065.4
transmembrane protein 256
chr17_-_57247632 0.41 ENSMUST00000005975.6
G protein-coupled receptor 108
chr19_+_11965817 0.40 ENSMUST00000025590.9
oxysterol binding protein
chrX_+_159708593 0.38 ENSMUST00000080394.6
SH3-domain kinase binding protein 1
chr7_-_126897424 0.38 ENSMUST00000120007.1
transmembrane protein 219
chr12_-_83921809 0.38 ENSMUST00000135962.1
ENSMUST00000155112.1
ENSMUST00000136848.1
ENSMUST00000126943.1
numb gene homolog (Drosophila)
chr7_-_45510400 0.37 ENSMUST00000033096.7
nucleobindin 1
chr15_+_101473472 0.37 ENSMUST00000088049.3
keratin 86
chr2_-_84715160 0.37 ENSMUST00000035840.5
zinc finger, DHHC domain containing 5
chr10_-_80421847 0.35 ENSMUST00000156244.1
transcription factor 3
chr7_-_121035096 0.35 ENSMUST00000065740.2
predicted gene 9905
chr5_-_137684665 0.30 ENSMUST00000100544.4
ENSMUST00000031736.9
ENSMUST00000151839.1
ArfGAP with FG repeats 2
chr4_-_129261394 0.30 ENSMUST00000145261.1
expressed sequence C77080
chr12_-_83921899 0.30 ENSMUST00000117217.1
numb gene homolog (Drosophila)
chr13_+_23746734 0.29 ENSMUST00000099703.2
histone cluster 1, H2bb
chr11_+_103133333 0.27 ENSMUST00000124928.1
ENSMUST00000062530.4
hexamethylene bis-acetamide inducible 2
chr7_+_3645267 0.26 ENSMUST00000038913.9
CCR4-NOT transcription complex, subunit 3
chr11_+_103133303 0.26 ENSMUST00000107037.1
hexamethylene bis-acetamide inducible 2
chr18_+_61639542 0.24 ENSMUST00000183083.1
ENSMUST00000183087.1
predicted gene, 20748
chr5_-_53707532 0.23 ENSMUST00000031093.3
cholecystokinin A receptor
chr4_+_80834298 0.23 ENSMUST00000102831.1
tyrosinase-related protein 1
chr4_+_80834123 0.23 ENSMUST00000133655.1
ENSMUST00000006151.6
tyrosinase-related protein 1
chr7_+_43690418 0.23 ENSMUST00000056329.6
kallikrein related-peptidase 14
chr2_-_167833642 0.22 ENSMUST00000143649.1
RIKEN cDNA 1200007C13 gene
chr15_+_66670749 0.21 ENSMUST00000065916.7
thyroglobulin
chr4_+_19818722 0.20 ENSMUST00000035890.7
solute carrier family 7, (cationic amino acid transporter, y+ system) member 13
chr2_-_130424242 0.17 ENSMUST00000089581.4
PC-esterase domain containing 1A
chr4_+_134397380 0.17 ENSMUST00000105870.1
platelet-activating factor acetylhydrolase 2
chr7_+_24370255 0.17 ENSMUST00000171904.1
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr15_-_101892916 0.16 ENSMUST00000100179.1
keratin 76
chr12_-_108179237 0.16 ENSMUST00000071095.7
SET domain containing 3
chr6_+_92092369 0.15 ENSMUST00000113463.1
nuclear receptor subfamily 2, group C, member 2
chr4_-_62470868 0.15 ENSMUST00000135811.1
ENSMUST00000120095.1
ENSMUST00000030087.7
ENSMUST00000107452.1
ENSMUST00000155522.1
WD repeat domain 31
chr12_+_52699297 0.13 ENSMUST00000095737.3
A kinase (PRKA) anchor protein 6
chr7_-_127208423 0.09 ENSMUST00000120705.1
TBC1 domain family, member 10b
chr12_-_108179210 0.09 ENSMUST00000125916.2
ENSMUST00000109879.1
SET domain containing 3
chr3_-_155055341 0.07 ENSMUST00000064076.3
TNNI3 interacting kinase
chr2_-_130424673 0.07 ENSMUST00000110277.1
PC-esterase domain containing 1A
chr5_-_87482258 0.06 ENSMUST00000079811.6
ENSMUST00000144144.1
UDP glucuronosyltransferase 2 family, polypeptide A1
chr6_-_129622685 0.05 ENSMUST00000032252.5
killer cell lectin-like receptor subfamily K, member 1
chr3_-_142169311 0.05 ENSMUST00000106230.1
bone morphogenetic protein receptor, type 1B
chr15_-_13173607 0.04 ENSMUST00000036439.4
cadherin 6
chr3_+_109573907 0.03 ENSMUST00000106576.2
vav 3 oncogene
chr14_-_73049107 0.03 ENSMUST00000044664.4
ENSMUST00000169168.1
cysteinyl leukotriene receptor 2
chrX_-_60893430 0.02 ENSMUST00000135107.2
SRY-box containing gene 3
chr4_+_144893127 0.00 ENSMUST00000142808.1
dehydrogenase/reductase (SDR family) member 3
chr13_+_118714678 0.00 ENSMUST00000022246.8
fibroblast growth factor 10
chr12_+_72441852 0.00 ENSMUST00000162159.1
leucine rich repeat containing 9
chr7_+_25267669 0.00 ENSMUST00000169266.1
capicua homolog (Drosophila)

Network of associatons between targets according to the STRING database.

First level regulatory network of Hmx3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0030862 neuroblast division in subventricular zone(GO:0021849) positive regulation of polarized epithelial cell differentiation(GO:0030862)
0.2 0.5 GO:0006583 melanin biosynthetic process from tyrosine(GO:0006583)
0.1 0.9 GO:0051026 chiasma assembly(GO:0051026)
0.1 0.2 GO:0002023 reduction of food intake in response to dietary excess(GO:0002023)
0.1 0.4 GO:0002326 B cell lineage commitment(GO:0002326)
0.0 0.4 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.0 1.4 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.0 0.2 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.0 0.1 GO:1902261 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316) positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.0 0.2 GO:0015705 iodide transport(GO:0015705)
0.0 0.4 GO:0044126 regulation of growth of symbiont in host(GO:0044126)
0.0 0.2 GO:0007320 insemination(GO:0007320)
0.0 0.6 GO:0042036 negative regulation of cytokine biosynthetic process(GO:0042036)
0.0 0.1 GO:0002223 stimulatory C-type lectin receptor signaling pathway(GO:0002223)
0.0 0.5 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.0 2.0 GO:0060349 bone morphogenesis(GO:0060349)
0.0 0.2 GO:0046541 saliva secretion(GO:0046541)
0.0 0.2 GO:0048733 sebaceous gland development(GO:0048733)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.1 0.4 GO:0090498 extrinsic component of Golgi membrane(GO:0090498)
0.0 0.3 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 1.1 GO:1990391 DNA repair complex(GO:1990391)
0.0 0.9 GO:0000795 synaptonemal complex(GO:0000795)
0.0 0.5 GO:0045095 keratin filament(GO:0045095)
0.0 0.4 GO:0000788 nuclear nucleosome(GO:0000788)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 GO:0030983 mismatched DNA binding(GO:0030983)
0.1 0.5 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.1 0.5 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 0.4 GO:0070644 vitamin D response element binding(GO:0070644)
0.0 0.2 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.7 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.2 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 0.5 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.4 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 2.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.2 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.0 0.4 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.1 GO:0031013 troponin I binding(GO:0031013)
0.0 1.4 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.0 GO:0004974 leukotriene receptor activity(GO:0004974)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 0.4 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 1.4 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.9 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.7 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 1.2 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.6 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.4 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.4 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation