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12D miR HR13_24

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Results for Irf3

Z-value: 0.80

Motif logo

Transcription factors associated with Irf3

Gene Symbol Gene ID Gene Info
ENSMUSG00000003184.8 interferon regulatory factor 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Irf3mm10_v2_chr7_+_44997648_44997700-0.402.2e-01Click!

Activity profile of Irf3 motif

Sorted Z-values of Irf3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr8_+_61928081 1.24 ENSMUST00000154398.1
ENSMUST00000093485.2
ENSMUST00000156980.1
ENSMUST00000070631.7
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr3_+_142560351 0.99 ENSMUST00000106221.1
guanylate binding protein 3
chr3_+_142560108 0.92 ENSMUST00000128609.1
ENSMUST00000029935.7
guanylate binding protein 3
chr3_+_142560052 0.80 ENSMUST00000106222.2
guanylate binding protein 3
chr7_+_104244449 0.79 ENSMUST00000106849.2
ENSMUST00000060315.5
tripartite motif-containing 34A
chr5_-_120907510 0.74 ENSMUST00000080322.7
2'-5' oligoadenylate synthetase 1A
chr7_+_104244465 0.74 ENSMUST00000106848.1
tripartite motif-containing 34A
chr5_-_120887582 0.71 ENSMUST00000086368.5
2'-5' oligoadenylate synthetase 1G
chr1_-_85270543 0.70 ENSMUST00000093506.5
ENSMUST00000064341.8
RIKEN cDNA C130026I21 gene
chr7_-_104353328 0.67 ENSMUST00000130139.1
ENSMUST00000059037.8
tripartite motif-containing 12C
chr16_-_35871544 0.67 ENSMUST00000042665.8
poly (ADP-ribose) polymerase family, member 14
chr11_-_83530505 0.66 ENSMUST00000035938.2
chemokine (C-C motif) ligand 5
chr10_+_128270546 0.65 ENSMUST00000105238.3
ENSMUST00000085708.2
signal transducer and activator of transcription 2
chr5_-_120812506 0.64 ENSMUST00000117193.1
ENSMUST00000130045.1
2'-5' oligoadenylate synthetase 1C
chr17_+_23660477 0.62 ENSMUST00000062967.8
coiled-coil domain containing 64B
chr5_-_120812484 0.61 ENSMUST00000125547.1
2'-5' oligoadenylate synthetase 1C
chr2_+_93187542 0.59 ENSMUST00000111266.1
ENSMUST00000150462.1
transformation related protein 53 inducible protein 11
chr6_-_3399545 0.59 ENSMUST00000120087.3
sterile alpha motif domain containing 9-like
chr7_+_104244496 0.59 ENSMUST00000106854.1
ENSMUST00000143414.1
tripartite motif-containing 34A
chr17_-_34187219 0.56 ENSMUST00000173831.1
proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
chr7_+_78913765 0.53 ENSMUST00000038142.8
interferon-stimulated protein
chr11_-_49064202 0.51 ENSMUST00000046745.6
T cell specific GTPase 2
chr7_-_104315455 0.48 ENSMUST00000106837.1
ENSMUST00000106839.2
ENSMUST00000070943.6
tripartite motif-containing 12A
chr9_-_22130598 0.45 ENSMUST00000115315.2
acid phosphatase 5, tartrate resistant
chr2_+_93187574 0.42 ENSMUST00000090554.4
transformation related protein 53 inducible protein 11
chr11_-_48992226 0.40 ENSMUST00000059930.2
ENSMUST00000068063.3
predicted gene 12185
T cell specific GTPase 1
chr5_+_114896936 0.39 ENSMUST00000031542.9
ENSMUST00000146072.1
ENSMUST00000150361.1
2'-5' oligoadenylate synthetase-like 2
chr2_-_62646146 0.39 ENSMUST00000112459.3
ENSMUST00000028259.5
interferon induced with helicase C domain 1
chr18_-_32559914 0.38 ENSMUST00000174000.1
ENSMUST00000174459.1
glycophorin C
chr7_-_3502465 0.38 ENSMUST00000065703.7
T cell-interacting, activating receptor on myeloid cells 1
chr7_+_78914216 0.37 ENSMUST00000120331.2
interferon-stimulated protein
chr11_+_58215028 0.36 ENSMUST00000108836.1
immunity-related GTPase family M member 2
chr7_+_78913436 0.35 ENSMUST00000121645.1
interferon-stimulated protein
chr3_+_81932601 0.35 ENSMUST00000029649.2
cathepsin O
chr4_-_40239700 0.33 ENSMUST00000142055.1
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr4_-_40239779 0.33 ENSMUST00000037907.6
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr11_+_58199556 0.33 ENSMUST00000035266.4
ENSMUST00000094169.4
ENSMUST00000168280.1
ENSMUST00000058704.8
interferon gamma induced GTPase
immunity-related GTPase family M member 2
chr1_+_85600672 0.31 ENSMUST00000080204.4
Sp140 nuclear body protein
chr6_-_39118211 0.29 ENSMUST00000038398.6
poly (ADP-ribose) polymerase family, member 12
chr7_-_141266415 0.29 ENSMUST00000106023.1
ENSMUST00000097952.2
ENSMUST00000026571.4
interferon regulatory factor 7
chr11_-_100704217 0.28 ENSMUST00000017974.6
DEXH (Asp-Glu-X-His) box polypeptide 58
chr6_-_125231772 0.28 ENSMUST00000043422.7
TAP binding protein-like
chr7_-_104288094 0.28 ENSMUST00000098179.2
tripartite motif-containing 5
chr4_-_156200818 0.26 ENSMUST00000085425.4
ISG15 ubiquitin-like modifier
chr1_-_85109449 0.25 ENSMUST00000161724.1
RIKEN cDNA A530032D15Rik gene
chr1_-_85109846 0.25 ENSMUST00000161675.1
ENSMUST00000160792.1
RIKEN cDNA A530032D15Rik gene
chr19_+_36409719 0.24 ENSMUST00000062389.5
polycomb group ring finger 5
chr11_-_48871344 0.23 ENSMUST00000049519.3
immunity-related GTPase family M member 1
chr2_+_122147680 0.22 ENSMUST00000102476.4
beta-2 microglobulin
chr3_+_142530329 0.22 ENSMUST00000171263.1
ENSMUST00000045097.9
guanylate binding protein 7
chr16_+_23609895 0.22 ENSMUST00000038423.5
receptor transporter protein 4
chr13_+_40859768 0.21 ENSMUST00000110191.2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr13_+_74639866 0.20 ENSMUST00000169114.1
endoplasmic reticulum aminopeptidase 1
chr9_-_15045378 0.19 ENSMUST00000164273.1
pannexin 1
chr9_-_14718381 0.19 ENSMUST00000115643.1
piwi-like RNA-mediated gene silencing 4
chr11_+_109362771 0.19 ENSMUST00000020930.7
ENSMUST00000106702.3
guanine nucleotide binding protein, alpha 13
chr13_-_23710714 0.18 ENSMUST00000091707.6
ENSMUST00000006787.7
ENSMUST00000091706.6
hemochromatosis
chr2_-_167062981 0.17 ENSMUST00000048988.7
zinc finger, NFX1-type containing 1
chr15_-_77411034 0.16 ENSMUST00000089452.5
ENSMUST00000081776.3
apolipoprotein L 9a
chr1_+_61638819 0.16 ENSMUST00000138768.1
ENSMUST00000075374.3
par-3 partitioning defective 3 homolog B (C. elegans)
chr15_-_39112642 0.16 ENSMUST00000022908.8
solute carrier family 25, member 32
chr2_-_51934644 0.15 ENSMUST00000165313.1
RNA binding motif protein 43
chr11_-_48871408 0.15 ENSMUST00000097271.2
immunity-related GTPase family M member 1
chr11_+_83852920 0.14 ENSMUST00000108113.1
HNF1 homeobox B
chr7_-_102565425 0.14 ENSMUST00000106913.1
ENSMUST00000033264.4
tripartite motif-containing 21
chr8_-_71537402 0.13 ENSMUST00000051672.7
bone marrow stromal cell antigen 2
chr19_+_34583528 0.13 ENSMUST00000102825.3
interferon-induced protein with tetratricopeptide repeats 3
chr6_+_34863130 0.13 ENSMUST00000074949.3
transmembrane protein 140
chr3_-_69127098 0.12 ENSMUST00000029353.2
karyopherin (importin) alpha 4
chr16_+_38346986 0.12 ENSMUST00000050273.8
ENSMUST00000120495.1
ENSMUST00000119704.1
cytochrome c oxidase assembly protein 17
predicted gene 21987
chr6_-_54972603 0.11 ENSMUST00000060655.8
nucleotide-binding oligomerization domain containing 1
chr5_-_137116177 0.11 ENSMUST00000054384.5
ENSMUST00000152207.1
tripartite motif-containing 56
chr2_-_145935014 0.11 ENSMUST00000001818.4
Crn, crooked neck-like 1 (Drosophila)
chr19_+_43752996 0.10 ENSMUST00000026199.7
ENSMUST00000112047.3
ENSMUST00000153295.1
cutC copper transporter homolog (E.coli)
chr15_+_39112868 0.10 ENSMUST00000022909.8
DDB1 and CUL4 associated factor 13
chr3_-_151749877 0.10 ENSMUST00000029671.7
interferon-induced protein 44
chr2_-_173218879 0.10 ENSMUST00000109116.2
ENSMUST00000029018.7
Z-DNA binding protein 1
chr17_+_57358682 0.10 ENSMUST00000086763.5
ENSMUST00000004850.7
EGF-like module containing, mucin-like, hormone receptor-like sequence 1
chr16_+_35938470 0.10 ENSMUST00000114878.1
poly (ADP-ribose) polymerase family, member 9
chr2_-_51934943 0.10 ENSMUST00000102767.1
ENSMUST00000102768.1
RNA binding motif protein 43
chr16_+_35938972 0.09 ENSMUST00000023622.6
ENSMUST00000114877.1
poly (ADP-ribose) polymerase family, member 9
chr11_-_121229293 0.07 ENSMUST00000106115.1
ENSMUST00000038709.7
ENSMUST00000147490.1
cDNA sequence BC017643
chr17_+_36837123 0.07 ENSMUST00000179968.1
ENSMUST00000130367.1
ENSMUST00000130801.1
ENSMUST00000144182.1
ENSMUST00000123715.1
ENSMUST00000053434.8
tripartite motif-containing 26
chr4_+_44012638 0.06 ENSMUST00000107847.3
ENSMUST00000170241.1
clathrin, light polypeptide (Lca)
chr7_-_45136102 0.06 ENSMUST00000125500.1
FMS-like tyrosine kinase 3 ligand
chr2_+_38998302 0.05 ENSMUST00000112872.1
WD repeat domain 38
chr1_+_171388954 0.04 ENSMUST00000056449.8
Rho GTPase activating protein 30
chr15_+_32920723 0.04 ENSMUST00000022871.5
syndecan 2
chr2_+_145934800 0.04 ENSMUST00000138774.1
ENSMUST00000152515.1
ENSMUST00000130168.1
ENSMUST00000133433.1
ENSMUST00000118002.1
RIKEN cDNA 4930529M08 gene
chr4_+_44012661 0.04 ENSMUST00000107849.3
ENSMUST00000107851.3
ENSMUST00000107845.3
clathrin, light polypeptide (Lca)
chr2_-_173276144 0.02 ENSMUST00000139306.1
prostate transmembrane protein, androgen induced 1
chr6_-_38354243 0.01 ENSMUST00000114900.1
zinc finger CCCH type, antiviral 1
chr7_+_104300230 0.01 ENSMUST00000106847.1
tripartite motif-containing 34B
chr9_-_35176039 0.00 ENSMUST00000119847.1
ENSMUST00000034539.5
decapping enzyme, scavenger
chr15_+_77729091 0.00 ENSMUST00000109775.2
apolipoprotein L 9b

Network of associatons between targets according to the STRING database.

First level regulatory network of Irf3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.3 1.3 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.2 1.1 GO:0035546 interferon-beta secretion(GO:0035546) regulation of interferon-beta secretion(GO:0035547) positive regulation of interferon-beta secretion(GO:0035549)
0.2 0.7 GO:0061762 CAMKK-AMPK signaling cascade(GO:0061762)
0.2 0.7 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.2 0.7 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634) positive regulation of natural killer cell chemotaxis(GO:2000503)
0.1 2.9 GO:0044406 adhesion of symbiont to host(GO:0044406)
0.1 0.2 GO:0002481 antigen processing and presentation of exogenous peptide antigen via MHC class Ib(GO:0002477) antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent(GO:0002481)
0.1 0.5 GO:0002589 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589)
0.1 0.5 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.1 0.6 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.1 0.2 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.1 0.3 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)
0.1 0.4 GO:0060332 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335) positive regulation of autophagosome maturation(GO:1901098)
0.0 0.1 GO:1904959 regulation of electron carrier activity(GO:1904732) regulation of cytochrome-c oxidase activity(GO:1904959)
0.0 0.1 GO:0061295 regulation of pronephros size(GO:0035565) mesonephros morphogenesis(GO:0061206) mesonephric nephron development(GO:0061215) mesonephric nephron morphogenesis(GO:0061228) mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis(GO:0061235) regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061295) negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061296) mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:1901146)
0.0 0.2 GO:0036438 maintenance of lens transparency(GO:0036438)
0.0 0.3 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.8 GO:0071357 type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.0 1.0 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.0 3.9 GO:0051607 defense response to virus(GO:0051607)
0.0 0.1 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
0.0 0.1 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
0.0 0.2 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.0 0.2 GO:0010529 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)
0.0 0.8 GO:0048525 negative regulation of viral process(GO:0048525)
0.0 0.1 GO:0042228 interleukin-8 biosynthetic process(GO:0042228)
0.0 0.1 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0 0.2 GO:0006544 glycine metabolic process(GO:0006544)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.6 GO:0020003 symbiont-containing vacuole(GO:0020003)
0.1 0.9 GO:1990462 omegasome(GO:1990462)
0.1 0.6 GO:1990111 spermatoproteasome complex(GO:1990111)
0.0 0.2 GO:0071547 piP-body(GO:0071547)
0.0 0.4 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 0.1 GO:0099631 postsynaptic endocytic zone cytoplasmic component(GO:0099631)
0.0 0.4 GO:0044754 autolysosome(GO:0044754)
0.0 0.7 GO:0015030 Cajal body(GO:0015030)
0.0 0.1 GO:0071012 catalytic step 1 spliceosome(GO:0071012)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0008859 exoribonuclease II activity(GO:0008859)
0.3 3.1 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.2 0.7 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.1 0.7 GO:0051434 BH3 domain binding(GO:0051434)
0.1 0.2 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.1 0.9 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.1 0.2 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.2 GO:0034584 piRNA binding(GO:0034584)
0.0 0.5 GO:0003993 acid phosphatase activity(GO:0003993)
0.0 0.2 GO:0031849 olfactory receptor binding(GO:0031849)
0.0 0.7 GO:0070403 NAD+ binding(GO:0070403)
0.0 0.1 GO:0003692 left-handed Z-DNA binding(GO:0003692)
0.0 0.6 GO:0070628 proteasome binding(GO:0070628)
0.0 2.1 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.2 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.0 0.3 GO:0031386 protein tag(GO:0031386)
0.0 0.2 GO:0039706 co-receptor binding(GO:0039706)
0.0 0.4 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.1 GO:0016531 copper chaperone activity(GO:0016531)
0.0 4.0 GO:0003924 GTPase activity(GO:0003924)
0.0 0.2 GO:0005243 gap junction channel activity(GO:0005243)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 2.7 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.7 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 0.2 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.1 0.2 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 2.2 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.1 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.7 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.2 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome