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12D miR HR13_24

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Results for Hoxb6

Z-value: 0.40

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Transcription factors associated with Hoxb6

Gene Symbol Gene ID Gene Info
ENSMUSG00000000690.4 homeobox B6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxb6mm10_v2_chr11_+_96298955_96299083-0.422.0e-01Click!

Activity profile of Hoxb6 motif

Sorted Z-values of Hoxb6 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_119238794 0.59 ENSMUST00000026360.8
integrin beta 8
chr7_+_113207465 0.42 ENSMUST00000047321.7
aryl hydrocarbon receptor nuclear translocator-like
chr13_-_92030897 0.37 ENSMUST00000149630.1
RAS protein-specific guanine nucleotide-releasing factor 2
chrX_+_164162167 0.36 ENSMUST00000131543.1
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr3_+_60081861 0.32 ENSMUST00000029326.5
succinate receptor 1
chr9_+_21955747 0.30 ENSMUST00000053583.5
SWIM type zinc finger 7 associated protein 1
chr6_+_142298419 0.23 ENSMUST00000041993.2
islet amyloid polypeptide
chr7_+_51880312 0.23 ENSMUST00000145049.1
growth arrest specific 2
chr8_+_13435459 0.21 ENSMUST00000167071.1
ENSMUST00000167505.1
transmembrane protein 255B
chr11_+_58580837 0.20 ENSMUST00000169428.2
olfactory receptor 325
chr6_-_52012476 0.18 ENSMUST00000078214.5
src family associated phosphoprotein 2
chr10_-_64090265 0.18 ENSMUST00000105439.1
leucine rich repeat transmembrane neuronal 3
chr11_-_58502554 0.17 ENSMUST00000170501.2
ENSMUST00000081743.2
olfactory receptor 331
chr14_+_118137101 0.16 ENSMUST00000022728.2
G protein-coupled receptor 180
chr9_+_54538984 0.15 ENSMUST00000060242.5
ENSMUST00000118413.1
SH2 domain containing 7
chr11_-_99244058 0.14 ENSMUST00000103132.3
ENSMUST00000038214.6
keratin 222
chr6_+_49319274 0.14 ENSMUST00000055559.7
ENSMUST00000114491.1
coiled-coil domain containing 126
chr1_-_45503282 0.12 ENSMUST00000086430.4
collagen, type V, alpha 2
chr8_+_31111816 0.12 ENSMUST00000046941.7
ring finger protein 122
chr3_-_79145875 0.12 ENSMUST00000118340.1
Rap guanine nucleotide exchange factor (GEF) 2
chr19_+_26748268 0.11 ENSMUST00000175791.1
ENSMUST00000176698.1
ENSMUST00000177252.1
ENSMUST00000176475.1
ENSMUST00000112637.2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr8_+_111033890 0.11 ENSMUST00000034441.7
alanyl-tRNA synthetase
chr1_-_138175283 0.10 ENSMUST00000182755.1
ENSMUST00000183262.1
ENSMUST00000027645.7
ENSMUST00000112036.2
ENSMUST00000182283.1
protein tyrosine phosphatase, receptor type, C
chr4_+_15881255 0.10 ENSMUST00000029876.1
calbindin 1
chrX_-_101222426 0.10 ENSMUST00000120389.1
ENSMUST00000156473.1
ENSMUST00000077876.3
sorting nexin 12
chr2_+_86041317 0.10 ENSMUST00000111589.1
olfactory receptor 1033
chr4_-_138326234 0.09 ENSMUST00000105817.3
ENSMUST00000030536.6
PTEN induced putative kinase 1
chr1_+_161395409 0.09 ENSMUST00000028024.4
tumor necrosis factor (ligand) superfamily, member 4
chr1_-_138175126 0.09 ENSMUST00000183301.1
protein tyrosine phosphatase, receptor type, C
chr11_-_69795930 0.08 ENSMUST00000045971.8
cholinergic receptor, nicotinic, beta polypeptide 1 (muscle)
chrX_-_143933204 0.07 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
doublecortin
chr5_-_87092546 0.07 ENSMUST00000132667.1
ENSMUST00000145617.1
ENSMUST00000094649.4
UDP glucuronosyltransferase 2 family, polypeptide B36
chr2_+_125859134 0.06 ENSMUST00000028636.6
ENSMUST00000125084.1
galactokinase 2
chr1_-_138175238 0.06 ENSMUST00000182536.1
protein tyrosine phosphatase, receptor type, C
chr3_-_116712644 0.06 ENSMUST00000029569.2
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr14_+_32599922 0.05 ENSMUST00000068938.5
paired related homeobox protein-like 1
chr11_-_96977660 0.05 ENSMUST00000107626.1
ENSMUST00000107624.1
Sp2 transcription factor
chr12_+_103388656 0.05 ENSMUST00000101094.2
ENSMUST00000021620.6
OTU domain, ubiquitin aldehyde binding 2
chr19_-_6925367 0.04 ENSMUST00000057716.4
testis expressed 40
chrX_+_107088452 0.04 ENSMUST00000150494.1
purinergic receptor P2Y, G-protein coupled 10
chr3_-_94412883 0.04 ENSMUST00000181305.1
RIKEN cDNA 1700040D17 gene
chr6_-_119388671 0.03 ENSMUST00000169744.1
adiponectin receptor 2
chrX_-_143933089 0.03 ENSMUST00000087313.3
doublecortin
chr5_+_31526989 0.03 ENSMUST00000114533.2
ENSMUST00000117262.1
ENSMUST00000117319.1
solute carrier family 4 (anion exchanger), member 1, adaptor protein
chr1_-_22805994 0.02 ENSMUST00000097808.4
regulating synaptic membrane exocytosis 1
chr3_+_66985647 0.02 ENSMUST00000162362.1
ENSMUST00000065074.7
arginine/serine-rich coiled-coil 1
chr4_+_33062999 0.02 ENSMUST00000108162.1
ENSMUST00000024035.2
gamma-aminobutyric acid (GABA) C receptor, subunit rho 2
chr13_-_85127514 0.01 ENSMUST00000179230.1
predicted gene 4076
chr4_-_134853294 0.01 ENSMUST00000030628.8
transmembrane protein 57
chr1_-_36273425 0.01 ENSMUST00000056946.6
neuralized homolog 3 homolog (Drosophila)
chr10_-_39122277 0.00 ENSMUST00000136546.1
family with sequence similarity 229, member B
chr8_-_77610668 0.00 ENSMUST00000141202.1
ENSMUST00000152168.1
transmembrane protein 184C

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxb6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)
0.1 0.4 GO:0015801 aromatic amino acid transport(GO:0015801) tryptophan transport(GO:0015827)
0.1 0.3 GO:0002378 immunoglobulin biosynthetic process(GO:0002378) regulation of hematopoietic stem cell migration(GO:2000471) positive regulation of hematopoietic stem cell migration(GO:2000473)
0.0 0.1 GO:0045626 negative regulation of T-helper 1 cell differentiation(GO:0045626)
0.0 0.1 GO:2000670 positive regulation of dendritic cell apoptotic process(GO:2000670)
0.0 0.1 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.0 0.1 GO:0072025 distal convoluted tubule development(GO:0072025) metanephric distal convoluted tubule development(GO:0072221) metanephric distal tubule development(GO:0072235)
0.0 0.1 GO:2000642 negative regulation of early endosome to late endosome transport(GO:2000642)
0.0 0.1 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.0 0.2 GO:0097647 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.0 0.6 GO:0001573 ganglioside metabolic process(GO:0001573)
0.0 0.1 GO:1903384 neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:0036482) positive regulation of mitochondrial electron transport, NADH to ubiquinone(GO:1902958) regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903383) negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903384)
0.0 0.1 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.0 0.1 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.0 0.2 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.0 0.4 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.4 GO:0033391 chromatoid body(GO:0033391)
0.0 0.6 GO:0008305 integrin complex(GO:0008305)
0.0 0.1 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.1 0.4 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.0 0.4 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.1 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.0 0.1 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.0 0.1 GO:0004335 galactokinase activity(GO:0004335)
0.0 0.1 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.1 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.1 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.4 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.4 ST G ALPHA S PATHWAY G alpha s Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.4 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.4 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA