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12D miR HR13_24

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Results for Hnf1a

Z-value: 0.45

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Transcription factors associated with Hnf1a

Gene Symbol Gene ID Gene Info
ENSMUSG00000029556.6 HNF1 homeobox A

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hnf1amm10_v2_chr5_-_114971056_1149710790.264.3e-01Click!

Activity profile of Hnf1a motif

Sorted Z-values of Hnf1a motif

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_103863551 0.97 ENSMUST00000085056.6
ENSMUST00000072876.5
ENSMUST00000124717.1
serine (or cysteine) peptidase inhibitor, clade A, member 1A
chr12_-_103738158 0.96 ENSMUST00000095450.4
serine (or cysteine) preptidase inhibitor, clade A, member 1B
chr12_-_103904887 0.91 ENSMUST00000074051.5
serine (or cysteine) peptidase inhibitor, clade A, member 1C
chr12_-_103956891 0.80 ENSMUST00000085054.4
serine (or cysteine) peptidase inhibitor, clade A, member 1E
chr12_-_103773592 0.61 ENSMUST00000078869.5
serine (or cysteine) peptidase inhibitor, clade A, member 1D
chr1_-_130661613 0.43 ENSMUST00000027657.7
complement component 4 binding protein
chr1_-_130661584 0.37 ENSMUST00000137276.2
complement component 4 binding protein
chr9_-_70934808 0.37 ENSMUST00000034731.8
lipase, hepatic
chr7_+_30493622 0.36 ENSMUST00000058280.6
ENSMUST00000133318.1
ENSMUST00000142575.1
ENSMUST00000131040.1
proline dehydrogenase (oxidase) 2
chr4_+_11758147 0.36 ENSMUST00000029871.5
ENSMUST00000108303.1
cadherin 17
chr6_+_21986887 0.35 ENSMUST00000151315.1
cadherin-like and PC-esterase domain containing 1
chr1_-_82768449 0.32 ENSMUST00000027331.2
transmembrane 4 L six family member 20
chr5_+_90490714 0.31 ENSMUST00000042755.3
alpha fetoprotein
chr11_+_115307155 0.30 ENSMUST00000055490.2
otopetrin 2
chr11_+_7197780 0.30 ENSMUST00000020704.7
insulin-like growth factor binding protein 1
chr9_+_53771499 0.29 ENSMUST00000048670.8
solute carrier family 35, member F2
chr5_+_33104219 0.29 ENSMUST00000011178.2
solute carrier family 5 (sodium/glucose cotransporter), member 1
chr10_+_76147451 0.29 ENSMUST00000020450.3
solute carrier family 5, member 4a
chr2_+_163506808 0.29 ENSMUST00000143911.1
hepatic nuclear factor 4, alpha
chr5_+_90460889 0.27 ENSMUST00000031314.8
albumin
chr13_+_54701457 0.27 ENSMUST00000037145.7
cadherin-related family member 2
chr3_-_72967854 0.25 ENSMUST00000167334.1
sucrase isomaltase (alpha-glucosidase)
chr3_+_94398517 0.24 ENSMUST00000050975.3
leucine rich repeat and Ig domain containing 4
chr3_-_69859875 0.23 ENSMUST00000051239.7
ENSMUST00000171529.1
serine palmitoyltransferase, small subunit B
chr15_-_79285470 0.22 ENSMUST00000170955.1
BAI1-associated protein 2-like 2
chr19_+_6105774 0.22 ENSMUST00000044451.3
N-acetylated alpha-linked acidic dipeptidase-like 1
chr12_-_103657159 0.19 ENSMUST00000044159.6
serine (or cysteine) peptidase inhibitor, clade A, member 6
chr11_-_6230127 0.18 ENSMUST00000004505.2
NPC1-like 1
chr16_-_79091078 0.18 ENSMUST00000023566.4
ENSMUST00000060402.5
transmembrane protease, serine 15
chr7_+_140763739 0.18 ENSMUST00000026552.7
cytochrome P450, family 2, subfamily e, polypeptide 1
chr2_+_163547148 0.18 ENSMUST00000109411.1
ENSMUST00000018094.6
hepatic nuclear factor 4, alpha
chr15_-_79285502 0.17 ENSMUST00000165408.1
BAI1-associated protein 2-like 2
chr4_-_32923455 0.17 ENSMUST00000035719.4
ENSMUST00000084749.1
ankyrin repeat domain 6
chr2_+_162987502 0.16 ENSMUST00000117123.1
serum/glucocorticoid regulated kinase 2
chr5_+_35041539 0.16 ENSMUST00000030985.6
hepatocyte growth factor activator
chr2_+_162987330 0.16 ENSMUST00000018012.7
serum/glucocorticoid regulated kinase 2
chr8_-_95142477 0.14 ENSMUST00000034240.7
ENSMUST00000169748.1
kinesin family member C3
chr11_-_98022594 0.14 ENSMUST00000103144.3
ENSMUST00000017552.6
ENSMUST00000092736.4
ENSMUST00000107562.1
calcium channel, voltage-dependent, beta 1 subunit
chr5_-_89457763 0.14 ENSMUST00000049209.8
group specific component
chr1_+_172698046 0.14 ENSMUST00000038495.3
C-reactive protein, pentraxin-related
chr8_-_93535707 0.14 ENSMUST00000077816.6
carboxylesterase 5A
chr7_-_119479249 0.13 ENSMUST00000033263.4
uromodulin
chr5_-_87337165 0.12 ENSMUST00000031195.2
UDP glucuronosyltransferase 2 family, polypeptide A3
chr13_+_55152640 0.12 ENSMUST00000005452.5
fibroblast growth factor receptor 4
chr16_-_38433145 0.12 ENSMUST00000002926.6
phospholipase A1 member A
chr17_+_71204647 0.11 ENSMUST00000126681.1
lipin 2
chr18_-_43737186 0.10 ENSMUST00000025381.2
serine peptidase inhibitor, Kazal type 3
chr5_-_114658414 0.10 ENSMUST00000112225.1
ENSMUST00000071968.2
transient receptor potential cation channel, subfamily V, member 4
chr4_-_139968026 0.09 ENSMUST00000105031.2
kelch domain containing 7A
chr3_-_75270073 0.09 ENSMUST00000039047.4
serine (or cysteine) peptidase inhibitor, clade I, member 2
chr5_+_31297551 0.08 ENSMUST00000072228.5
glucokinase regulatory protein
chr16_+_20591156 0.08 ENSMUST00000159780.1
von Willebrand factor A domain containing 5B2
chr4_-_63172118 0.07 ENSMUST00000030042.2
kinesin family member 12
chr6_+_38918969 0.07 ENSMUST00000003017.6
thromboxane A synthase 1, platelet
chr3_+_90537242 0.07 ENSMUST00000098911.3
S100 calcium binding protein A16
chr5_-_87092546 0.06 ENSMUST00000132667.1
ENSMUST00000145617.1
ENSMUST00000094649.4
UDP glucuronosyltransferase 2 family, polypeptide B36
chr11_+_118428203 0.06 ENSMUST00000124861.1
C1q and tumor necrosis factor related protein 1
chr9_+_21835506 0.06 ENSMUST00000058777.6
predicted gene 6484
chr11_-_11898044 0.06 ENSMUST00000066237.3
dopa decarboxylase
chr9_-_106158109 0.05 ENSMUST00000159809.1
ENSMUST00000162562.1
ENSMUST00000036382.6
ENSMUST00000112543.2
glycerate kinase
chr6_-_41704339 0.05 ENSMUST00000031899.8
Kell blood group
chr11_+_78178105 0.05 ENSMUST00000147819.1
TLC domain containing 1
chr3_+_136670076 0.05 ENSMUST00000070198.7
protein phosphatase 3, catalytic subunit, alpha isoform
chr2_-_20968526 0.04 ENSMUST00000141298.2
ENSMUST00000125783.2
Rho GTPase activating protein 21
chr11_-_11898092 0.04 ENSMUST00000178704.1
dopa decarboxylase
chr3_-_83049797 0.03 ENSMUST00000048246.3
fibrinogen beta chain
chr2_+_32525013 0.03 ENSMUST00000150621.1
predicted gene 13412
chr5_-_114443993 0.03 ENSMUST00000112245.1
methylmalonic aciduria (cobalamin deficiency) type B homolog (human)
chr2_+_110597298 0.03 ENSMUST00000045972.6
ENSMUST00000111026.2
solute carrier family 5 (sodium/glucose cotransporter), member 12
chr5_+_32247351 0.03 ENSMUST00000101376.2
phospholipase B1
chrX_-_43167817 0.03 ENSMUST00000115058.1
ENSMUST00000115059.1
teneurin transmembrane protein 1
chr14_-_37110087 0.02 ENSMUST00000179488.1
RIKEN cDNA 2610528A11 gene
chr10_+_87859062 0.02 ENSMUST00000095360.4
insulin-like growth factor 1
chr9_-_77045788 0.02 ENSMUST00000034911.6
tubulointerstitial nephritis antigen
chr4_-_94650134 0.02 ENSMUST00000053419.2
leucine rich repeat containing 19
chr16_+_20651652 0.02 ENSMUST00000007212.8
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
chr4_-_97778042 0.02 ENSMUST00000146447.1
RIKEN cDNA E130114P18 gene
chr1_+_88211956 0.02 ENSMUST00000073049.6
UDP glucuronosyltransferase 1 family, polypeptide A1
chr11_+_70519619 0.02 ENSMUST00000179000.1
glycolipid transfer protein domain containing 2
chr7_+_141215852 0.01 ENSMUST00000046890.5
ENSMUST00000133763.1
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
chr10_+_87859255 0.01 ENSMUST00000105300.2
insulin-like growth factor 1
chr7_+_45062429 0.01 ENSMUST00000107830.1
ENSMUST00000003513.3
ENSMUST00000107829.1
ENSMUST00000150609.1
nitric oxide synthase interacting protein
chrX_+_101377267 0.01 ENSMUST00000052130.7
gap junction protein, beta 1
chr3_+_90537306 0.01 ENSMUST00000107335.1
S100 calcium binding protein A16
chr19_-_47919269 0.01 ENSMUST00000095998.5
inositol 1,4,5-triphosphate receptor interacting protein
chr17_+_12378603 0.01 ENSMUST00000014578.5
plasminogen
chr5_+_122391878 0.01 ENSMUST00000102525.4
actin related protein 2/3 complex, subunit 3
chr18_-_6516089 0.00 ENSMUST00000115870.2
enhancer of polycomb homolog 1 (Drosophila)
chrX_+_101376359 0.00 ENSMUST00000119080.1
gap junction protein, beta 1
chr5_-_148995147 0.00 ENSMUST00000147473.1
katanin p60 subunit A-like 1
chr2_-_155357392 0.00 ENSMUST00000165234.1
ENSMUST00000077626.6
phosphatidylinositol glycan anchor biosynthesis, class U
chr10_+_63061582 0.00 ENSMUST00000020266.8
ENSMUST00000178684.1
phenazine biosynthesis-like protein domain containing 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Hnf1a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:1902569 regulation of activation of JAK2 kinase activity(GO:0010534) activation of JAK2 kinase activity(GO:0042977) negative regulation of activation of JAK2 kinase activity(GO:1902569)
0.1 0.4 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.1 0.4 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.1 0.3 GO:0032532 regulation of microvillus length(GO:0032532)
0.1 0.3 GO:0001951 intestinal D-glucose absorption(GO:0001951)
0.0 0.3 GO:0046010 positive regulation of circadian sleep/wake cycle, non-REM sleep(GO:0046010)
0.0 0.1 GO:0072025 distal convoluted tubule development(GO:0072025) metanephric distal convoluted tubule development(GO:0072221) metanephric distal tubule development(GO:0072235)
0.0 0.1 GO:0061144 alveolar secondary septum development(GO:0061144)
0.0 0.4 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372)
0.0 0.1 GO:0071477 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.0 0.2 GO:1904220 regulation of serine C-palmitoyltransferase activity(GO:1904220)
0.0 0.3 GO:1904659 glucose transmembrane transport(GO:1904659)
0.0 0.1 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 0.1 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.0 0.3 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.0 0.1 GO:0009750 response to fructose(GO:0009750)
0.0 1.0 GO:0006953 acute-phase response(GO:0006953)
0.0 0.7 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 0.4 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.0 0.2 GO:0030299 intestinal cholesterol absorption(GO:0030299)
0.0 0.0 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244)
0.0 0.1 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.0 0.1 GO:2000860 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.0 0.3 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0 0.2 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.0 0.2 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 GO:0071439 clathrin complex(GO:0071439)
0.0 0.2 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.3 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.0 0.1 GO:0005915 zonula adherens(GO:0005915)
0.0 0.3 GO:0034364 high-density lipoprotein particle(GO:0034364)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0070540 stearic acid binding(GO:0070540)
0.1 0.4 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.1 0.5 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.1 0.3 GO:0004566 beta-glucuronidase activity(GO:0004566)
0.1 0.2 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
0.1 0.2 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.1 0.6 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.0 0.1 GO:1902271 D3 vitamins binding(GO:1902271)
0.0 0.3 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 3.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.1 GO:0015275 stretch-activated, cation-selective, calcium channel activity(GO:0015275)
0.0 0.1 GO:0004058 aromatic-L-amino-acid decarboxylase activity(GO:0004058) L-dopa decarboxylase activity(GO:0036468)
0.0 0.1 GO:0019864 IgG binding(GO:0019864)
0.0 0.1 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.1 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.3 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.3 GO:0017081 chloride channel regulator activity(GO:0017081)
0.0 0.1 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.2 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.4 GO:0071949 FAD binding(GO:0071949)
0.0 0.2 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 0.1 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.4 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.3 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.2 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type