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12D miR HR13_24

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Results for Foxo6

Z-value: 0.58

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Transcription factors associated with Foxo6

Gene Symbol Gene ID Gene Info
ENSMUSG00000052135.8 forkhead box O6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Foxo6mm10_v2_chr4_-_120287349_1202873490.313.5e-01Click!

Activity profile of Foxo6 motif

Sorted Z-values of Foxo6 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_106167564 0.96 ENSMUST00000063062.8
chitinase 3-like 3
chr5_+_110330697 0.84 ENSMUST00000112481.1
polymerase (DNA directed), epsilon
chr4_-_89294608 0.81 ENSMUST00000107131.1
cyclin-dependent kinase inhibitor 2A
chr1_-_38664947 0.76 ENSMUST00000039827.7
ENSMUST00000027250.7
AF4/FMR2 family, member 3
chr9_+_7272514 0.72 ENSMUST00000015394.8
matrix metallopeptidase 13
chr4_+_134510999 0.65 ENSMUST00000105866.2
aurora kinase A and ninein interacting protein
chr17_-_31129602 0.60 ENSMUST00000024827.4
trefoil factor 3, intestinal
chr14_-_47418407 0.59 ENSMUST00000043296.3
discs, large (Drosophila) homolog-associated protein 5
chr16_+_17146937 0.50 ENSMUST00000115706.1
ENSMUST00000069064.4
YdjC homolog (bacterial)
chr3_-_27896360 0.44 ENSMUST00000058077.3
transmembrane protein 212
chr19_-_4877882 0.41 ENSMUST00000006626.3
actinin alpha 3
chr18_+_5593566 0.38 ENSMUST00000160910.1
zinc finger E-box binding homeobox 1
chr16_-_88563166 0.37 ENSMUST00000049697.4
claudin 8
chr12_-_91384403 0.36 ENSMUST00000141429.1
centrosomal protein 128
chr9_+_98490522 0.34 ENSMUST00000035029.2
retinol binding protein 2, cellular
chr1_-_160077918 0.29 ENSMUST00000028061.3
RIKEN cDNA 4930562F07 gene
chr7_+_28440927 0.28 ENSMUST00000078845.6
glia maturation factor, gamma
chr11_-_12027958 0.27 ENSMUST00000109654.1
growth factor receptor bound protein 10
chr12_-_102423741 0.26 ENSMUST00000110020.1
legumain
chr18_+_60212080 0.26 ENSMUST00000031549.5
predicted gene 4951
chrX_+_134585644 0.25 ENSMUST00000113211.1
ribosomal protein L36A
chr7_+_44225430 0.24 ENSMUST00000075162.3
kallikrein 1
chr17_+_48346465 0.23 ENSMUST00000113237.3
triggering receptor expressed on myeloid cells 2
chr3_+_96680093 0.22 ENSMUST00000130429.1
ankyrin repeat domain 35
chr3_-_127780461 0.22 ENSMUST00000029662.5
ENSMUST00000161239.1
alpha-kinase 1
chr11_-_94392917 0.21 ENSMUST00000178136.1
ENSMUST00000021231.7
ATP-binding cassette, sub-family C (CFTR/MRP), member 3
chr2_-_11603192 0.20 ENSMUST00000040314.5
RNA binding motif protein 17
chr1_-_139858684 0.20 ENSMUST00000094489.3
complement factor H-related 2
chr12_-_113260217 0.20 ENSMUST00000178282.1
immunoglobulin heavy constant alpha
chr5_-_99037035 0.19 ENSMUST00000031277.6
protein kinase, cGMP-dependent, type II
chr18_-_12305638 0.18 ENSMUST00000122408.1
ENSMUST00000118525.1
ENSMUST00000142066.1
ankyrin repeat domain 29
chr4_+_48663502 0.17 ENSMUST00000030033.4
muscle-related coiled-coil protein
chr17_+_25471564 0.17 ENSMUST00000025002.1
tektin 4
chr3_-_49757257 0.17 ENSMUST00000035931.7
protocadherin 18
chr13_+_76579670 0.17 ENSMUST00000126960.1
ENSMUST00000109583.2
multiple C2 domains, transmembrane 1
chr15_+_103453782 0.16 ENSMUST00000047405.7
NCK associated protein 1 like
chr1_-_162898484 0.16 ENSMUST00000143123.1
flavin containing monooxygenase 2
chr5_-_117389029 0.15 ENSMUST00000111953.1
ENSMUST00000086461.6
replication factor C (activator 1) 5
chr17_+_23600856 0.15 ENSMUST00000095595.2
ENSMUST00000115509.1
ENSMUST00000120967.1
ENSMUST00000148062.1
ENSMUST00000129227.1
ENSMUST00000123866.1
zinc finger and SCAN domain containing 10
chr15_+_52712434 0.14 ENSMUST00000037115.7
mediator complex subunit 30
chr5_-_65391408 0.13 ENSMUST00000057885.6
ribosomal protein L9
chr5_-_87092546 0.13 ENSMUST00000132667.1
ENSMUST00000145617.1
ENSMUST00000094649.4
UDP glucuronosyltransferase 2 family, polypeptide B36
chr13_-_4279420 0.13 ENSMUST00000021632.3
aldo-keto reductase family 1, member C12
chr6_+_57002300 0.12 ENSMUST00000079669.4
vomeronasal 1 receptor 6
chr12_-_98577940 0.12 ENSMUST00000110113.1
potassium channel, subfamily K, member 10
chr5_-_65391380 0.12 ENSMUST00000120094.1
ENSMUST00000118543.1
ENSMUST00000127874.1
ribosomal protein L9
chr11_+_46235460 0.12 ENSMUST00000060185.2
fibronectin type III domain containing 9
chr3_-_51408925 0.12 ENSMUST00000038108.6
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1
chr5_+_92386879 0.12 ENSMUST00000128246.1
ADP-ribosyltransferase 3
chr14_+_65605267 0.11 ENSMUST00000079469.6
nuclear GTPase, germinal center associated
chr2_+_4718145 0.10 ENSMUST00000056914.6
BEN domain containing 7
chr8_+_46986913 0.10 ENSMUST00000039840.7
ENSMUST00000119686.1
ectonucleotide pyrophosphatase/phosphodiesterase 6
chr7_+_143052739 0.09 ENSMUST00000037941.9
CD81 antigen
chr9_-_22071345 0.09 ENSMUST00000179605.1
ENSMUST00000043922.6
zinc finger protein 653
chr6_+_56956466 0.08 ENSMUST00000096612.3
vomeronasal 1 receptor 4
chr5_+_87000838 0.08 ENSMUST00000031186.7
UDP glucuronosyltransferase 2 family, polypeptide B35
chr15_+_3270767 0.08 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
selenoprotein P, plasma, 1
chr1_+_93928037 0.08 ENSMUST00000177958.1
predicted gene 9994
chr7_+_28808795 0.08 ENSMUST00000172529.1
heterogeneous nuclear ribonucleoprotein L
chr2_-_93046053 0.08 ENSMUST00000111272.1
ENSMUST00000178666.1
ENSMUST00000147339.1
PR domain containing 11
chr12_+_119443410 0.08 ENSMUST00000048880.6
metastasis associated in colon cancer 1
chr5_-_52190484 0.07 ENSMUST00000031061.7
DEAH (Asp-Glu-Ala-His) box polypeptide 15
chr5_+_115279666 0.07 ENSMUST00000040421.4
coenzyme Q5 homolog, methyltransferase (yeast)
chr10_+_79879614 0.07 ENSMUST00000006679.8
proteinase 3
chrX_+_106920618 0.07 ENSMUST00000060576.7
lysophosphatidic acid receptor 4
chr7_+_28441026 0.06 ENSMUST00000135686.1
glia maturation factor, gamma
chr4_-_149099802 0.06 ENSMUST00000103217.4
peroxisomal biogenesis factor 14
chr9_-_51328898 0.06 ENSMUST00000039959.4
RIKEN cDNA 1810046K07 gene
chr3_-_146596588 0.06 ENSMUST00000029836.4
deoxyribonuclease II beta
chr1_-_44061936 0.06 ENSMUST00000168641.1
predicted gene 8251
chr7_-_107757993 0.06 ENSMUST00000052438.7
cytochrome b5 reductase 2
chr7_-_14562171 0.06 ENSMUST00000181796.1
vomeronasal 1 receptor 90
chr3_+_103968110 0.05 ENSMUST00000117150.1
ENSMUST00000063717.7
ENSMUST00000055425.8
ENSMUST00000123611.1
ENSMUST00000090685.4
putative homeodomain transcription factor 1
chr16_-_38800193 0.05 ENSMUST00000057767.4
uroplakin 1B
chr18_-_60648290 0.05 ENSMUST00000143275.2
synaptopodin
chrX_-_8193387 0.04 ENSMUST00000143223.1
ENSMUST00000033509.8
phenylalkylamine Ca2+ antagonist (emopamil) binding protein
chr9_+_6168638 0.04 ENSMUST00000058692.7
platelet-derived growth factor, D polypeptide
chr2_-_155357392 0.04 ENSMUST00000165234.1
ENSMUST00000077626.6
phosphatidylinositol glycan anchor biosynthesis, class U
chr16_-_34263179 0.03 ENSMUST00000114949.1
ENSMUST00000114954.1
kalirin, RhoGEF kinase
chr8_+_83566671 0.03 ENSMUST00000036996.5
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7
chr17_-_24696147 0.03 ENSMUST00000046839.8
growth factor, erv1 (S. cerevisiae)-like (augmenter of liver regeneration)
chr6_+_57702601 0.03 ENSMUST00000072954.1
ENSMUST00000050077.8
LanC (bacterial lantibiotic synthetase component C)-like 2
chr19_+_8892987 0.03 ENSMUST00000096249.5
integrator complex subunit 5
chr7_+_140881898 0.03 ENSMUST00000026560.7
proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
chr10_+_39420009 0.03 ENSMUST00000157009.1
Fyn proto-oncogene
chr4_-_139131058 0.03 ENSMUST00000143971.1
mitochondrial inner membrane organizing system 1
chr4_+_108479081 0.02 ENSMUST00000155068.1
zinc finger, CCHC domain containing 11
chr11_+_85832551 0.02 ENSMUST00000000095.6
T-box 2
chr5_+_65391497 0.02 ENSMUST00000031101.3
ENSMUST00000122026.1
lipoic acid synthetase
chr19_-_46969474 0.01 ENSMUST00000086961.7
5'-nucleotidase, cytosolic II
chr2_-_84425258 0.01 ENSMUST00000074262.2
calcitonin receptor-like
chr5_-_87424201 0.00 ENSMUST00000072818.5
UDP glucuronosyltransferase 2 family, polypeptide B38

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxo6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0045004 DNA replication proofreading(GO:0045004)
0.2 0.7 GO:0090187 positive regulation of pancreatic juice secretion(GO:0090187)
0.2 0.8 GO:2000435 positive regulation of macrophage apoptotic process(GO:2000111) regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
0.1 0.4 GO:0043465 regulation of fast-twitch skeletal muscle fiber contraction(GO:0031446) positive regulation of fast-twitch skeletal muscle fiber contraction(GO:0031448) regulation of fermentation(GO:0043465) regulation of bone mineralization involved in bone maturation(GO:1900157) regulation of NAD metabolic process(GO:1902688) regulation of glucose catabolic process to lactate via pyruvate(GO:1904023)
0.1 0.3 GO:0071846 actin filament debranching(GO:0071846)
0.1 0.2 GO:0002588 positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002582) positive regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002588)
0.1 0.3 GO:0006624 vacuolar protein processing(GO:0006624)
0.1 0.2 GO:2001226 negative regulation of chloride transport(GO:2001226)
0.0 0.2 GO:0042908 xenobiotic transport(GO:0042908)
0.0 0.3 GO:0006776 vitamin A metabolic process(GO:0006776)
0.0 0.2 GO:0070358 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376) actin polymerization-dependent cell motility(GO:0070358)
0.0 0.2 GO:0080154 regulation of fertilization(GO:0080154)
0.0 0.4 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.0 0.3 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719)
0.0 0.1 GO:0016561 protein import into peroxisome matrix, translocation(GO:0016561)
0.0 0.1 GO:0072592 oxygen metabolic process(GO:0072592)
0.0 0.1 GO:1904352 positive regulation of protein catabolic process in the vacuole(GO:1904352)
0.0 0.0 GO:0007521 muscle cell fate determination(GO:0007521)
0.0 0.2 GO:1900264 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.0 0.1 GO:0019695 choline metabolic process(GO:0019695)
0.0 0.1 GO:0097029 mature conventional dendritic cell differentiation(GO:0097029)
0.0 0.6 GO:0035116 embryonic hindlimb morphogenesis(GO:0035116)
0.0 0.2 GO:0019236 response to pheromone(GO:0019236)
0.0 0.1 GO:0098886 modification of dendritic spine(GO:0098886)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.1 0.8 GO:0001652 granular component(GO:0001652)
0.1 0.7 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.6 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.2 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.2 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.1 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.0 0.1 GO:1990415 Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429)
0.0 0.4 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.2 GO:0031209 SCAR complex(GO:0031209)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0055105 ubiquitin-protein transferase inhibitor activity(GO:0055105)
0.1 0.8 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.0 0.2 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.0 0.2 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.0 0.2 GO:0005550 pheromone binding(GO:0005550)
0.0 0.3 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.2 GO:0070891 lipoteichoic acid binding(GO:0070891)
0.0 0.3 GO:0019841 retinol binding(GO:0019841)
0.0 0.7 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.1 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 0.1 GO:0004531 deoxyribonuclease II activity(GO:0004531)
0.0 0.2 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.1 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0 0.2 GO:0034987 immunoglobulin receptor binding(GO:0034987)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.8 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.6 PID AURORA A PATHWAY Aurora A signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.0 0.2 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 0.7 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.3 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.8 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.3 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 0.3 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0 0.1 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels