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12D miR HR13_24

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Results for Hoxa1

Z-value: 0.74

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Transcription factors associated with Hoxa1

Gene Symbol Gene ID Gene Info
ENSMUSG00000029844.9 homeobox A1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxa1mm10_v2_chr6_-_52158292_52158324-0.758.0e-03Click!

Activity profile of Hoxa1 motif

Sorted Z-values of Hoxa1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr9_-_96862903 4.39 ENSMUST00000121077.1
ENSMUST00000124923.1
acid phosphatase-like 2
chr10_+_81628570 2.60 ENSMUST00000153573.1
ENSMUST00000119336.1
ankyrin repeat domain 24
chr9_-_21312255 2.58 ENSMUST00000115433.3
ENSMUST00000003397.7
adaptor protein complex AP-1, mu 2 subunit
chr4_-_106799779 1.44 ENSMUST00000145061.1
ENSMUST00000102762.3
acyl-CoA thioesterase 11
chr2_+_158375638 1.38 ENSMUST00000109488.1
small nucleolar RNA host gene 11
chr13_-_12340723 1.35 ENSMUST00000168193.1
ENSMUST00000110616.1
ENSMUST00000064204.7
actinin alpha 2
chr9_+_15239045 1.28 ENSMUST00000034413.6
V-set and transmembrane domain containing 5
chr16_+_38902305 1.26 ENSMUST00000023478.7
immunoglobulin superfamily, member 11
chr17_+_70522083 0.91 ENSMUST00000148486.1
ENSMUST00000133717.1
discs, large (Drosophila) homolog-associated protein 1
chr11_-_99244058 0.82 ENSMUST00000103132.3
ENSMUST00000038214.6
keratin 222
chr3_-_89093358 0.74 ENSMUST00000090929.5
ENSMUST00000052539.6
RUN and SH3 domain containing 1
chr6_-_52012476 0.69 ENSMUST00000078214.5
src family associated phosphoprotein 2
chr2_+_90885860 0.67 ENSMUST00000111466.2
C1q and tumor necrosis factor related protein 4
chr17_+_70522149 0.63 ENSMUST00000140728.1
discs, large (Drosophila) homolog-associated protein 1
chr4_-_143299498 0.63 ENSMUST00000030317.7
podoplanin
chr3_-_58525867 0.60 ENSMUST00000029385.7
stress-associated endoplasmic reticulum protein 1
chr5_-_135573036 0.60 ENSMUST00000004936.6
chemokine (C-C motif) ligand 24
chr4_-_106800249 0.53 ENSMUST00000148688.1
acyl-CoA thioesterase 11
chr13_+_72628802 0.52 ENSMUST00000074372.4
Iroquois related homeobox 2 (Drosophila)
chr7_+_123462274 0.51 ENSMUST00000033023.3
aquaporin 8
chr6_+_142298419 0.46 ENSMUST00000041993.2
islet amyloid polypeptide
chr5_-_107289561 0.45 ENSMUST00000031224.8
transforming growth factor, beta receptor III
chr11_-_102296618 0.45 ENSMUST00000107132.2
ENSMUST00000073234.2
ataxin 7-like 3
chr5_+_137030275 0.45 ENSMUST00000041543.8
VGF nerve growth factor inducible
chr10_+_26078255 0.44 ENSMUST00000041011.3
predicted gene 9767
chr10_+_81628540 0.43 ENSMUST00000123896.1
ankyrin repeat domain 24
chr8_-_8639363 0.43 ENSMUST00000152698.1
ephrin B2
chr1_+_60977898 0.43 ENSMUST00000027162.5
ENSMUST00000102827.3
inducible T cell co-stimulator
chr9_-_101034857 0.42 ENSMUST00000142676.1
ENSMUST00000149322.1
propionyl Coenzyme A carboxylase, beta polypeptide
chr9_+_59589288 0.41 ENSMUST00000121266.1
ENSMUST00000118164.1
CUGBP, Elav-like family member 6
chr4_-_143299463 0.41 ENSMUST00000119654.1
podoplanin
chr6_-_21851914 0.37 ENSMUST00000134635.1
ENSMUST00000123116.1
ENSMUST00000120965.1
tetraspanin 12
chr1_-_157412576 0.36 ENSMUST00000078308.6
ENSMUST00000139470.1
RAS protein activator like 2
chr14_+_56575603 0.36 ENSMUST00000161553.1
poly (ADP-ribose) polymerase family, member 4
chr11_+_62281457 0.36 ENSMUST00000101075.4
ENSMUST00000050646.6
tetratricopeptide repeat domain 19
chr11_-_40755201 0.35 ENSMUST00000020576.7
cyclin G1
chr3_-_89393629 0.35 ENSMUST00000124783.1
ENSMUST00000126027.1
zinc finger and BTB domain containing 7B
chr14_-_69503316 0.35 ENSMUST00000179116.2
predicted gene, 21464
chr6_-_52191695 0.34 ENSMUST00000101395.2
homeobox A4
chr13_+_72628831 0.34 ENSMUST00000169028.1
Iroquois related homeobox 2 (Drosophila)
chr5_-_143732273 0.34 ENSMUST00000053287.5
ubiquitin specific peptidase 42
chr4_+_43669610 0.31 ENSMUST00000107866.1
transmembrane protein 8B
chr6_+_48395586 0.30 ENSMUST00000114571.1
ENSMUST00000114572.3
ENSMUST00000031815.5
KRAB-A domain containing 1
chrX_-_134161928 0.30 ENSMUST00000033611.4
X Kell blood group precursor related X linked
chr15_-_53346118 0.28 ENSMUST00000077273.2
exostoses (multiple) 1
chr11_-_20332654 0.28 ENSMUST00000004634.6
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr11_-_5898771 0.27 ENSMUST00000102921.3
myosin, light polypeptide 7, regulatory
chr6_+_49319274 0.26 ENSMUST00000055559.7
ENSMUST00000114491.1
coiled-coil domain containing 126
chr17_-_90455872 0.25 ENSMUST00000174337.1
ENSMUST00000172466.1
neurexin I
chr6_+_48395652 0.25 ENSMUST00000077093.4
KRAB-A domain containing 1
chr17_-_34804546 0.23 ENSMUST00000025223.8
cytochrome P450, family 21, subfamily a, polypeptide 1
chr11_-_116189542 0.23 ENSMUST00000148601.1
acyl-Coenzyme A oxidase 1, palmitoyl
chrX_-_75578188 0.22 ENSMUST00000033545.5
RAB39B, member RAS oncogene family
chr3_-_79145875 0.22 ENSMUST00000118340.1
Rap guanine nucleotide exchange factor (GEF) 2
chr10_-_81545175 0.21 ENSMUST00000043604.5
guanine nucleotide binding protein, alpha 11
chr5_-_137684665 0.20 ENSMUST00000100544.4
ENSMUST00000031736.9
ENSMUST00000151839.1
ArfGAP with FG repeats 2
chr6_+_71494003 0.20 ENSMUST00000114179.2
ring finger protein 103
chr16_+_23107413 0.20 ENSMUST00000023599.6
ENSMUST00000168891.1
eukaryotic translation initiation factor 4A2
chrX_+_56454871 0.20 ENSMUST00000039374.2
ENSMUST00000101553.2
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
chr7_+_144838590 0.19 ENSMUST00000105898.1
fibroblast growth factor 3
chr10_-_10429839 0.16 ENSMUST00000045328.7
androglobin
chr4_-_145315143 0.16 ENSMUST00000030339.6
tumor necrosis factor receptor superfamily, member 8
chr4_-_35845204 0.16 ENSMUST00000164772.1
ENSMUST00000065173.2
leucine rich repeat and Ig domain containing 2
chr4_-_11981265 0.15 ENSMUST00000098260.2
predicted gene 10604
chr9_+_58129321 0.14 ENSMUST00000034880.3
stimulated by retinoic acid gene 6
chr7_+_140322602 0.14 ENSMUST00000078103.2
olfactory receptor 525
chr2_+_119972699 0.13 ENSMUST00000066058.7
mitogen-activated protein kinase binding protein 1
chr13_+_99184733 0.13 ENSMUST00000056558.8
zinc finger protein 366
chr9_+_58129062 0.13 ENSMUST00000085677.2
stimulated by retinoic acid gene 6
chr8_-_117673682 0.12 ENSMUST00000173522.1
ENSMUST00000174450.1
short chain dehydrogenase/reductase family 42E, member 1
chr10_+_75037291 0.12 ENSMUST00000139384.1
RAB36, member RAS oncogene family
chr6_+_91684061 0.12 ENSMUST00000032185.7
solute carrier family 6 (neurotransmitter transporter, taurine), member 6
chrX_-_37168829 0.11 ENSMUST00000046557.5
A kinase (PRKA) anchor protein 14
chr7_-_127708886 0.11 ENSMUST00000061468.8
B cell CLL/lymphoma 7C
chr5_-_123749393 0.11 ENSMUST00000057795.5
ENSMUST00000111515.1
ENSMUST00000182309.1
arginine/serine-rich coiled-coil 2
chr2_+_65845767 0.11 ENSMUST00000122912.1
cysteine-serine-rich nuclear protein 3
chr12_-_80260356 0.11 ENSMUST00000021554.8
actinin, alpha 1
chr11_+_103774150 0.10 ENSMUST00000000127.5
wingless-related MMTV integration site 3
chr13_-_60177357 0.10 ENSMUST00000065086.4
growth arrest specific 1
chr6_+_40442863 0.10 ENSMUST00000038907.8
ENSMUST00000141490.1
WEE1 homolog 2 (S. pombe)
chr12_+_53248677 0.08 ENSMUST00000101432.2
neuronal PAS domain protein 3
chr9_+_58129476 0.08 ENSMUST00000133287.1
stimulated by retinoic acid gene 6
chr9_+_110344185 0.07 ENSMUST00000142100.1
SREBF chaperone
chr1_+_153874335 0.06 ENSMUST00000055314.3
predicted gene 5531
chr10_+_14760221 0.06 ENSMUST00000020015.3
neuromedin B receptor
chr1_+_10993452 0.06 ENSMUST00000027056.5
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr1_+_89454769 0.06 ENSMUST00000027521.8
ENSMUST00000074945.5
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
chr15_-_73819410 0.05 ENSMUST00000110021.2
maestro heat-like repeat family member 5
chr5_-_123749371 0.05 ENSMUST00000182955.1
ENSMUST00000182489.1
ENSMUST00000050827.7
arginine/serine-rich coiled-coil 2
chr4_+_101507947 0.05 ENSMUST00000149047.1
ENSMUST00000106929.3
DnaJ (Hsp40) homolog, subfamily C, member 6
chr3_+_114030532 0.04 ENSMUST00000123619.1
ENSMUST00000092155.5
collagen, type XI, alpha 1
chr15_+_74516196 0.04 ENSMUST00000042035.9
brain-specific angiogenesis inhibitor 1
chr4_+_101507855 0.03 ENSMUST00000038207.5
DnaJ (Hsp40) homolog, subfamily C, member 6
chr15_+_102990576 0.03 ENSMUST00000001703.6
homeobox C8
chrX_-_8132770 0.03 ENSMUST00000130832.1
ENSMUST00000033506.6
ENSMUST00000115623.1
ENSMUST00000153839.1
WD repeat domain 13
chr17_+_8434423 0.02 ENSMUST00000074667.2
brachyury
chr17_-_25081138 0.02 ENSMUST00000024984.6
transmembrane protein 204
chr6_-_83677807 0.02 ENSMUST00000037882.6
CD207 antigen
chr17_-_51826562 0.01 ENSMUST00000024720.4
ENSMUST00000129667.1
ENSMUST00000156051.1
ENSMUST00000169480.1
ENSMUST00000148559.1
special AT-rich sequence binding protein 1
chr2_+_65845833 0.00 ENSMUST00000053910.3
cysteine-serine-rich nuclear protein 3

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxa1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:1904328 regulation of myofibroblast contraction(GO:1904328) myofibroblast contraction(GO:1990764)
0.3 1.3 GO:2001137 positive regulation of endocytic recycling(GO:2001137)
0.2 0.9 GO:0072272 proximal/distal pattern formation involved in metanephric nephron development(GO:0072272)
0.2 0.6 GO:2000418 positive regulation of eosinophil migration(GO:2000418)
0.1 0.4 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
0.1 1.5 GO:0070842 aggresome assembly(GO:0070842)
0.1 0.3 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376)
0.1 0.2 GO:2000670 positive regulation of dendritic cell apoptotic process(GO:2000670)
0.1 0.5 GO:0015722 canalicular bile acid transport(GO:0015722)
0.1 0.3 GO:0015825 L-serine transport(GO:0015825)
0.1 0.3 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.1 0.5 GO:0097647 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.1 0.4 GO:1903847 regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.1 0.6 GO:0060124 positive regulation of growth hormone secretion(GO:0060124)
0.0 2.4 GO:0009409 response to cold(GO:0009409)
0.0 0.3 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 0.3 GO:0061143 alveolar primary septum development(GO:0061143)
0.0 0.2 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.0 0.2 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.0 0.1 GO:1900425 negative regulation of defense response to bacterium(GO:1900425)
0.0 0.4 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0 0.4 GO:0002517 T cell tolerance induction(GO:0002517)
0.0 0.1 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.0 0.2 GO:0030916 otic vesicle formation(GO:0030916)
0.0 0.2 GO:0006705 mineralocorticoid biosynthetic process(GO:0006705)
0.0 0.4 GO:0016578 histone deubiquitination(GO:0016578)
0.0 0.4 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.4 GO:0071625 vocalization behavior(GO:0071625)
0.0 0.1 GO:0072318 clathrin coat disassembly(GO:0072318)
0.0 0.4 GO:0010842 retina layer formation(GO:0010842)
0.0 0.2 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0046691 intracellular canaliculus(GO:0046691)
0.1 0.4 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.1 1.0 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.1 2.6 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 1.3 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 0.1 GO:0032127 dense core granule membrane(GO:0032127)
0.0 0.4 GO:0000124 SAGA complex(GO:0000124)
0.0 0.4 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.3 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 1.1 GO:0005882 intermediate filament(GO:0005882)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0051373 FATZ binding(GO:0051373)
0.2 0.6 GO:0031728 CCR3 chemokine receptor binding(GO:0031728)
0.1 0.4 GO:0004658 propionyl-CoA carboxylase activity(GO:0004658)
0.1 1.5 GO:0015250 water channel activity(GO:0015250)
0.1 0.3 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.1 0.2 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.1 2.0 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.1 0.3 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.0 0.4 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.0 0.1 GO:0030977 taurine binding(GO:0030977)
0.0 0.2 GO:0016401 palmitoyl-CoA oxidase activity(GO:0016401)
0.0 0.3 GO:0022858 L-alanine transmembrane transporter activity(GO:0015180) alanine transmembrane transporter activity(GO:0022858)
0.0 0.2 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.1 GO:0004946 bombesin receptor activity(GO:0004946)
0.0 0.3 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.4 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.7 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.1 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.0 0.4 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.2 GO:0048406 nerve growth factor binding(GO:0048406)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.2 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 0.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.6 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 1.3 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 0.5 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.7 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.4 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.2 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.4 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.6 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.2 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism