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12D miR HR13_24

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Results for Trp63

Z-value: 0.48

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Transcription factors associated with Trp63

Gene Symbol Gene ID Gene Info
ENSMUSG00000022510.8 transformation related protein 63

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Trp63mm10_v2_chr16_+_25801907_258019280.421.9e-01Click!

Activity profile of Trp63 motif

Sorted Z-values of Trp63 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr17_+_29090969 1.04 ENSMUST00000119901.1
cyclin-dependent kinase inhibitor 1A (P21)
chr7_-_141443314 0.70 ENSMUST00000106005.2
leucine-rich and death domain containing
chr6_+_34709610 0.58 ENSMUST00000031775.6
caldesmon 1
chr6_+_34709442 0.51 ENSMUST00000115021.1
caldesmon 1
chr8_-_31918203 0.48 ENSMUST00000073884.4
neuregulin 1
chr3_-_108402589 0.45 ENSMUST00000147565.1
cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)
chr8_+_84686300 0.41 ENSMUST00000177531.1
tRNA methyltransferase 1
chr10_-_80671976 0.37 ENSMUST00000003433.6
MAP kinase-interacting serine/threonine kinase 2
chr1_-_9700209 0.36 ENSMUST00000088658.4
myeloblastosis oncogene-like 1
chr19_-_5875210 0.35 ENSMUST00000155227.1
FERM domain containing 8
chr7_-_116038734 0.34 ENSMUST00000166877.1
SRY-box containing gene 6
chr8_+_85432686 0.29 ENSMUST00000180883.1
RIKEN cDNA 1700051O22 Gene
chr7_-_126160992 0.26 ENSMUST00000164741.1
exportin 6
chrX_-_150812932 0.26 ENSMUST00000131241.1
ENSMUST00000147152.1
ENSMUST00000143843.1
melanoma antigen, family D, 2
chr2_+_25054396 0.25 ENSMUST00000102931.4
ENSMUST00000074422.7
ENSMUST00000132172.1
ENSMUST00000114388.1
ENSMUST00000114386.1
NMDA receptor synaptonuclear signaling and neuronal migration factor
chrX_-_150812715 0.21 ENSMUST00000112697.3
melanoma antigen, family D, 2
chr12_-_108003594 0.20 ENSMUST00000066060.4
B cell leukemia/lymphoma 11B
chr5_-_5265224 0.19 ENSMUST00000115450.1
cyclin-dependent kinase 14
chr10_-_61452658 0.18 ENSMUST00000167087.1
ENSMUST00000020288.7
eukaryotic translation initiation factor 4E binding protein 2
chr2_-_12301914 0.15 ENSMUST00000028106.4
integrin alpha 8
chr11_-_69948145 0.14 ENSMUST00000179298.1
ENSMUST00000018710.6
ENSMUST00000135437.1
ENSMUST00000141837.2
ENSMUST00000142500.1
solute carrier family 2 (facilitated glucose transporter), member 4
chr5_+_142401484 0.13 ENSMUST00000072837.5
forkhead box K1
chr4_-_96591555 0.12 ENSMUST00000055693.8
cytochrome P450, family 2, subfamily j, polypeptide 9
chr8_+_27085520 0.12 ENSMUST00000178514.1
ENSMUST00000033876.7
G protein-coupled receptor 124
chr8_-_85432841 0.10 ENSMUST00000047749.5
RIKEN cDNA 4921524J17 gene
chr8_-_47352348 0.10 ENSMUST00000110367.2
storkhead box 2
chr12_-_108003414 0.09 ENSMUST00000109887.1
ENSMUST00000109891.2
B cell leukemia/lymphoma 11B
chr11_-_95699143 0.09 ENSMUST00000062249.2
predicted gene 9796
chr8_+_27085835 0.09 ENSMUST00000165366.2
G protein-coupled receptor 124
chr4_+_43493345 0.09 ENSMUST00000030181.5
ENSMUST00000107922.2
coiled-coil domain containing 107
chr19_-_6080311 0.09 ENSMUST00000159832.1
vacuolar protein sorting 51 homolog (S. cerevisiae)
chr13_-_55021287 0.08 ENSMUST00000148221.1
ENSMUST00000052949.6
hexokinase 3
chrX_+_98149666 0.06 ENSMUST00000052837.7
androgen receptor
chr15_+_76696725 0.05 ENSMUST00000023203.4
glutamic pyruvic transaminase, soluble
chrX_+_136822781 0.05 ENSMUST00000113085.1
proteolipid protein (myelin) 1
chr19_-_5875268 0.04 ENSMUST00000025728.6
FERM domain containing 8
chr5_-_5266038 0.04 ENSMUST00000115451.1
ENSMUST00000115452.1
ENSMUST00000131392.1
cyclin-dependent kinase 14
chr1_+_180893107 0.04 ENSMUST00000085797.5
left-right determination factor 2
chrX_+_136822671 0.03 ENSMUST00000033800.6
proteolipid protein (myelin) 1
chr16_-_23930787 0.02 ENSMUST00000061030.8
receptor transporter protein 2
chr16_+_37868383 0.02 ENSMUST00000078717.6
leucine rich repeat containing 58
chr2_-_170427828 0.01 ENSMUST00000013667.2
ENSMUST00000109152.2
ENSMUST00000068137.4
breast carcinoma amplified sequence 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Trp63

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0002940 tRNA N2-guanine methylation(GO:0002940)
0.1 1.0 GO:0071493 cellular response to UV-B(GO:0071493)
0.1 0.3 GO:0097534 lymphoid lineage cell migration(GO:0097534) lymphoid lineage cell migration into thymus(GO:0097535)
0.1 0.4 GO:0033326 cerebrospinal fluid secretion(GO:0033326)
0.1 0.5 GO:0070294 renal sodium ion absorption(GO:0070294)
0.1 0.5 GO:0045213 neurotransmitter receptor metabolic process(GO:0045213)
0.1 0.3 GO:0099527 postsynapse to nucleus signaling pathway(GO:0099527)
0.0 0.2 GO:2000721 positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000721)
0.0 0.3 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0 0.4 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.0 0.1 GO:0060599 lateral sprouting involved in mammary gland duct morphogenesis(GO:0060599) tertiary branching involved in mammary gland duct morphogenesis(GO:0060748) positive regulation of epithelial cell proliferation involved in prostate gland development(GO:0060769)
0.0 1.1 GO:0006940 regulation of smooth muscle contraction(GO:0006940)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0070557 PCNA-p21 complex(GO:0070557)
0.1 1.1 GO:0030478 actin cap(GO:0030478)
0.0 0.2 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 0.1 GO:1990745 EARP complex(GO:1990745)
0.0 0.2 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.5 GO:0030673 axolemma(GO:0030673)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.1 0.5 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.1 0.4 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.0 0.4 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 0.4 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.1 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.0 0.2 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.5 PID ERBB NETWORK PATHWAY ErbB receptor signaling network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 1.0 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 1.1 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction