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12D miR HR13_24

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Results for Evx2

Z-value: 0.53

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Transcription factors associated with Evx2

Gene Symbol Gene ID Gene Info
ENSMUSG00000001815.9 even-skipped homeobox 2

Activity profile of Evx2 motif

Sorted Z-values of Evx2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr13_+_51645232 0.80 ENSMUST00000075853.5
CDC28 protein kinase regulatory subunit 2
chr2_+_119047116 0.68 ENSMUST00000152380.1
ENSMUST00000099542.2
cancer susceptibility candidate 5
chr2_+_119047129 0.68 ENSMUST00000153300.1
ENSMUST00000028799.5
cancer susceptibility candidate 5
chr16_-_45724600 0.66 ENSMUST00000096057.4
transgelin 3
chr9_+_47530173 0.66 ENSMUST00000114548.1
ENSMUST00000152459.1
ENSMUST00000143026.1
ENSMUST00000085909.2
ENSMUST00000114547.1
ENSMUST00000034581.3
cell adhesion molecule 1
chr1_+_91801453 0.56 ENSMUST00000007949.3
twist basic helix-loop-helix transcription factor 2
chr18_-_88927447 0.48 ENSMUST00000147313.1
suppressor of cytokine signaling 6
chr14_+_62292475 0.45 ENSMUST00000166879.1
ribonuclease H2, subunit B
chr7_-_140154712 0.40 ENSMUST00000059241.7
shadow of prion protein
chr2_+_154548888 0.37 ENSMUST00000045116.4
ENSMUST00000109709.3
RIKEN cDNA 1700003F12 gene
chr2_+_164613519 0.36 ENSMUST00000094346.2
WAP four-disulfide core domain 6B
chr19_+_47067721 0.35 ENSMUST00000026027.5
TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chrX_-_60893430 0.33 ENSMUST00000135107.2
SRY-box containing gene 3
chrX_-_111536325 0.29 ENSMUST00000156639.1
ribosomal protein S6 kinase polypeptide 6
chr19_-_55241236 0.29 ENSMUST00000069183.6
guanylate cyclase 2g
chr5_-_84417359 0.27 ENSMUST00000113401.1
Eph receptor A5
chr4_-_132345686 0.26 ENSMUST00000030726.6
regulator of chromosome condensation 1
chr7_-_24724237 0.26 ENSMUST00000081657.4
predicted gene 4763
chr11_-_120378692 0.25 ENSMUST00000026448.9
RIKEN cDNA 2310003H01 gene
chr4_-_132345715 0.25 ENSMUST00000084250.4
regulator of chromosome condensation 1
chrX_+_58030999 0.23 ENSMUST00000088631.4
ENSMUST00000088629.3
zinc finger protein of the cerebellum 3
chr16_-_42340595 0.21 ENSMUST00000102817.4
growth associated protein 43
chr4_+_109978004 0.20 ENSMUST00000061187.3
doublesex and mab-3 related transcription factor like family A2
chr19_+_41933464 0.18 ENSMUST00000026154.7
zinc finger, DHHC domain containing 16
chr8_-_35495487 0.18 ENSMUST00000033927.6
exoribonuclease 1
chr8_+_92855319 0.17 ENSMUST00000046290.1
lysophosphatidylcholine acyltransferase 2
chr6_+_41951625 0.17 ENSMUST00000031898.4
seminal vesicle antigen-like 1
chr12_-_98577940 0.17 ENSMUST00000110113.1
potassium channel, subfamily K, member 10
chr19_-_41933276 0.16 ENSMUST00000075280.4
ENSMUST00000112123.2
exosome component 1
chr1_-_134955847 0.16 ENSMUST00000168381.1
protein phosphatase 1, regulatory (inhibitor) subunit 12B
chrX_+_58030622 0.14 ENSMUST00000088627.4
zinc finger protein of the cerebellum 3
chr15_-_9529868 0.14 ENSMUST00000003981.4
interleukin 7 receptor
chr11_-_65269941 0.13 ENSMUST00000102635.3
myocardin
chr7_-_44257378 0.13 ENSMUST00000107945.1
ENSMUST00000118216.1
acid phosphatase, testicular
chr11_+_116657106 0.12 ENSMUST00000116318.2
predicted gene 11744
chr4_-_132075250 0.12 ENSMUST00000105970.1
ENSMUST00000105975.1
erythrocyte protein band 4.1
chr9_-_66514567 0.12 ENSMUST00000056890.8
F-box and leucine-rich repeat protein 22
chrX_-_57338598 0.12 ENSMUST00000033468.4
ENSMUST00000114736.1
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr2_+_69822370 0.12 ENSMUST00000053087.3
kelch-like 23
chr4_+_140701466 0.12 ENSMUST00000038893.5
ENSMUST00000138808.1
regulator of chromosome condensation 2
chr11_+_116843278 0.11 ENSMUST00000106370.3
methyltransferase like 23
chr18_+_9958147 0.11 ENSMUST00000025137.7
THO complex 1
chr9_+_66797039 0.10 ENSMUST00000098612.2
predicted gene 10647
chr2_+_91256813 0.10 ENSMUST00000144394.1
ENSMUST00000028694.5
ENSMUST00000168916.1
ENSMUST00000156919.1
protein kinase C and casein kinase substrate in neurons 3
chrM_+_7759 0.10 ENSMUST00000082407.1
ENSMUST00000082408.1
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chr3_-_15575065 0.10 ENSMUST00000091319.4
signal-regulatory protein beta 1B
chr18_-_24603791 0.10 ENSMUST00000070726.3
solute carrier family 39 (metal ion transporter), member 6
chr18_-_24603464 0.09 ENSMUST00000154205.1
solute carrier family 39 (metal ion transporter), member 6
chrX_-_20950597 0.09 ENSMUST00000009550.7
ELK1, member of ETS oncogene family
chr18_+_24603952 0.09 ENSMUST00000025120.6
elongator acetyltransferase complex subunit 2
chr10_+_70175011 0.09 ENSMUST00000156001.1
ENSMUST00000135607.1
coiled-coil domain containing 6
chr14_+_73173825 0.09 ENSMUST00000166875.1
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr17_-_47834682 0.08 ENSMUST00000066368.6
MyoD family inhibitor
chr2_-_155074447 0.08 ENSMUST00000137242.1
ENSMUST00000054607.9
S-adenosylhomocysteine hydrolase
chr1_+_36761847 0.07 ENSMUST00000027291.4
zeta-chain (TCR) associated protein kinase
chr1_-_134955908 0.07 ENSMUST00000045665.6
ENSMUST00000086444.4
ENSMUST00000112163.1
protein phosphatase 1, regulatory (inhibitor) subunit 12B
chr2_-_164613600 0.06 ENSMUST00000094351.4
ENSMUST00000109338.1
WAP four-disulfide core domain 8
chr3_+_94837533 0.06 ENSMUST00000107270.2
pogo transposable element with ZNF domain
chr10_+_97647084 0.06 ENSMUST00000105285.3
epiphycan
chr13_+_38204928 0.05 ENSMUST00000091641.5
ENSMUST00000178564.1
small nuclear ribonucleoprotein 48 (U11/U12)
chr11_+_75532099 0.05 ENSMUST00000169547.2
solute carrier family 43, member 2
chr11_-_113710017 0.04 ENSMUST00000018871.1
cleavage and polyadenylation specific factor 4-like
chrX_-_75163753 0.04 ENSMUST00000101433.2
small integral membrane protein 9
chr1_-_24612700 0.03 ENSMUST00000088336.1
predicted gene 10222
chr2_-_168767029 0.03 ENSMUST00000075044.3
sal-like 4 (Drosophila)
chr5_-_106926245 0.02 ENSMUST00000117588.1
HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)
chr14_-_59365465 0.02 ENSMUST00000095157.4
PHD finger protein 11D
chr18_+_12741324 0.02 ENSMUST00000115857.2
ENSMUST00000121018.1
ENSMUST00000119108.1
calcium-binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2)
chr9_-_107679592 0.02 ENSMUST00000010205.7
guanine nucleotide binding protein, alpha transducing 1
chrM_+_10167 0.01 ENSMUST00000082414.1
mitochondrially encoded NADH dehydrogenase 4
chr14_-_59365410 0.01 ENSMUST00000161031.1
ENSMUST00000160425.1
PHD finger protein 11D
chr2_-_168767136 0.01 ENSMUST00000029061.5
ENSMUST00000103074.1
sal-like 4 (Drosophila)

Network of associatons between targets according to the STRING database.

First level regulatory network of Evx2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0042271 unidimensional cell growth(GO:0009826) susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.1 0.4 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.1 0.6 GO:0061303 cornea development in camera-type eye(GO:0061303)
0.0 0.1 GO:1900239 regulation of phenotypic switching(GO:1900239) negative regulation of vascular associated smooth muscle cell migration(GO:1904753) regulation of cardiac vascular smooth muscle cell differentiation(GO:2000722) positive regulation of cardiac vascular smooth muscle cell differentiation(GO:2000724)
0.0 0.2 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)
0.0 0.2 GO:0016198 axon choice point recognition(GO:0016198)
0.0 0.6 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.0 0.3 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.0 0.1 GO:0002439 chronic inflammatory response to antigenic stimulus(GO:0002439)
0.0 0.2 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.0 0.1 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.0 0.3 GO:2000381 negative regulation of mesoderm development(GO:2000381)
0.0 0.2 GO:0031125 rRNA 3'-end processing(GO:0031125)
0.0 0.1 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.0 0.2 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.0 0.8 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.0 0.3 GO:0021854 hypothalamus development(GO:0021854)
0.0 0.1 GO:0043366 beta selection(GO:0043366)
0.0 0.2 GO:0030322 stabilization of membrane potential(GO:0030322)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.0 0.7 GO:0070852 cell body fiber(GO:0070852)
0.0 0.2 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.0 0.4 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.2 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.2 GO:0031527 filopodium membrane(GO:0031527)
0.0 0.2 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.1 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.8 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.3 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.1 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.1 0.5 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.1 0.4 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.1 0.2 GO:0071207 histone pre-mRNA stem-loop binding(GO:0071207)
0.1 0.2 GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.0 0.3 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.0 0.2 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 0.1 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.3 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.2 GO:0022841 potassium ion leak channel activity(GO:0022841)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.4 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.5 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.7 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.2 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.2 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels