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12D miR HR13_24

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Results for Foxo3

Z-value: 0.51

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Transcription factors associated with Foxo3

Gene Symbol Gene ID Gene Info
ENSMUSG00000048756.5 forkhead box O3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Foxo3mm10_v2_chr10_-_42276688_422767430.127.3e-01Click!

Activity profile of Foxo3 motif

Sorted Z-values of Foxo3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr9_+_98490522 1.46 ENSMUST00000035029.2
retinol binding protein 2, cellular
chr4_-_49549523 0.91 ENSMUST00000029987.9
aldolase B, fructose-bisphosphate
chr14_-_51773578 0.58 ENSMUST00000073860.5
angiogenin, ribonuclease A family, member 4
chr3_+_53488677 0.46 ENSMUST00000029307.3
stomatin (Epb7.2)-like 3
chr3_+_63295815 0.44 ENSMUST00000029400.1
membrane metallo endopeptidase
chr7_-_103813913 0.41 ENSMUST00000098192.3
hemoglobin, beta adult t chain
chr4_-_116405986 0.41 ENSMUST00000123072.1
ENSMUST00000144281.1
microtubule associated serine/threonine kinase 2
chr13_-_95478655 0.39 ENSMUST00000022186.3
S100 calcium binding protein, zeta
chr14_+_30879257 0.38 ENSMUST00000040715.6
musculoskeletal, embryonic nuclear protein 1
chr19_-_34255325 0.33 ENSMUST00000039631.8
actin, alpha 2, smooth muscle, aorta
chr3_-_27896360 0.32 ENSMUST00000058077.3
transmembrane protein 212
chr7_+_141476374 0.31 ENSMUST00000117634.1
tetraspanin 4
chr2_-_51149100 0.29 ENSMUST00000154545.1
ENSMUST00000017288.2
Rho family GTPase 3
chr16_-_38433145 0.28 ENSMUST00000002926.6
phospholipase A1 member A
chr4_-_87806276 0.28 ENSMUST00000148059.1
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr7_-_67803489 0.24 ENSMUST00000181235.1
RIKEN cDNA 4833412C05 gene
chr4_-_91376433 0.24 ENSMUST00000107109.2
ENSMUST00000107111.2
ENSMUST00000107120.1
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr19_+_53329413 0.24 ENSMUST00000025998.7
Max interacting protein 1
chr18_-_39489157 0.23 ENSMUST00000131885.1
nuclear receptor subfamily 3, group C, member 1
chr11_-_101785252 0.22 ENSMUST00000164750.1
ENSMUST00000107176.1
ENSMUST00000017868.6
ets variant gene 4 (E1A enhancer binding protein, E1AF)
chr6_+_15196949 0.20 ENSMUST00000151301.1
ENSMUST00000131414.1
ENSMUST00000140557.1
ENSMUST00000115469.1
forkhead box P2
chr19_+_5877794 0.20 ENSMUST00000145200.1
ENSMUST00000025732.7
ENSMUST00000125114.1
ENSMUST00000155697.1
solute carrier family 25, member 45
chr10_+_97565436 0.20 ENSMUST00000038160.4
lumican
chr11_-_68386821 0.19 ENSMUST00000021284.3
netrin 1
chr4_-_91376490 0.18 ENSMUST00000107124.3
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr7_+_29309429 0.18 ENSMUST00000137848.1
D4, zinc and double PHD fingers family 1
chr1_+_66386968 0.18 ENSMUST00000145419.1
microtubule-associated protein 2
chr11_-_48946148 0.18 ENSMUST00000104958.1
protease (prosome, macropain) activator subunit 2B
chr6_+_14901344 0.17 ENSMUST00000115477.1
forkhead box P2
chr11_-_94242701 0.17 ENSMUST00000061469.3
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
chr8_+_58912257 0.17 ENSMUST00000160055.1
cDNA sequence BC030500
chr2_+_124610573 0.16 ENSMUST00000103239.3
ENSMUST00000103240.2
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr1_+_20730903 0.16 ENSMUST00000027061.4
interleukin 17A
chr11_+_3332426 0.16 ENSMUST00000136474.1
phosphoinositide-3-kinase interacting protein 1
chr4_-_58206596 0.15 ENSMUST00000042850.8
sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
chr10_+_40349265 0.15 ENSMUST00000044672.4
ENSMUST00000095743.2
cyclin-dependent kinase 19
chr7_+_113765998 0.15 ENSMUST00000046687.9
spondin 1, (f-spondin) extracellular matrix protein
chr12_+_71016658 0.15 ENSMUST00000125125.1
AT rich interactive domain 4A (RBP1-like)
chr9_-_48835932 0.14 ENSMUST00000093852.3
zinc finger and BTB domain containing 16
chr15_+_79347534 0.14 ENSMUST00000096350.3
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)
chr2_-_118728430 0.14 ENSMUST00000102524.1
phospholipase C, beta 2
chr8_-_84773381 0.14 ENSMUST00000109764.1
nuclear factor I/X
chr15_+_79348061 0.14 ENSMUST00000163691.1
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)
chr7_+_30291659 0.14 ENSMUST00000014065.8
ENSMUST00000150892.1
ENSMUST00000126216.1
CAP-GLY domain containing linker protein 3
chr2_+_4718145 0.13 ENSMUST00000056914.6
BEN domain containing 7
chr2_-_118728345 0.13 ENSMUST00000159756.1
phospholipase C, beta 2
chr14_-_51913393 0.13 ENSMUST00000004673.7
ENSMUST00000111632.3
N-myc downstream regulated gene 2
chr2_+_127854628 0.12 ENSMUST00000028859.1
acyl-Coenzyme A oxidase-like
chr3_-_145649970 0.12 ENSMUST00000029846.3
cysteine rich protein 61
chr7_+_30291941 0.12 ENSMUST00000144508.1
CAP-GLY domain containing linker protein 3
chr1_+_12718496 0.12 ENSMUST00000088585.3
sulfatase 1
chr5_+_65131184 0.12 ENSMUST00000031089.5
ENSMUST00000101191.3
kelch-like 5
chr9_+_65361049 0.11 ENSMUST00000147185.1
predicted gene 514
chr13_+_60602182 0.11 ENSMUST00000044083.7
death associated protein kinase 1
chr12_+_38780817 0.11 ENSMUST00000160856.1
ets variant gene 1
chr12_+_71170589 0.11 ENSMUST00000129376.1
RIKEN cDNA 2700049A03 gene
chr4_-_137785371 0.10 ENSMUST00000133473.1
alkaline phosphatase, liver/bone/kidney
chr11_+_29463735 0.10 ENSMUST00000155854.1
coiled coil domain containing 88A
chr7_-_30559828 0.09 ENSMUST00000108164.1
lin-37 homolog (C. elegans)
chr9_-_58741543 0.08 ENSMUST00000098674.4
RIKEN cDNA 2410076I21 gene
chr11_+_7197780 0.08 ENSMUST00000020704.7
insulin-like growth factor binding protein 1
chrX_-_48208870 0.08 ENSMUST00000088935.3
zinc finger, DHHC domain containing 9
chr7_+_113766119 0.08 ENSMUST00000084696.4
spondin 1, (f-spondin) extracellular matrix protein
chr6_+_55836878 0.07 ENSMUST00000044729.6
coiled-coil domain containing 129
chr1_-_140183404 0.07 ENSMUST00000066859.6
ENSMUST00000111976.2
complement component factor h
chr1_-_140183283 0.07 ENSMUST00000111977.1
complement component factor h
chr2_-_126499839 0.07 ENSMUST00000040128.5
ATPase, class I, type 8B, member 4
chr16_-_38800193 0.07 ENSMUST00000057767.4
uroplakin 1B
chr8_-_25785154 0.07 ENSMUST00000038498.8
BCL2-associated athanogene 4
chr8_-_121083085 0.07 ENSMUST00000182264.1
Foxf1 adjacent non-coding developmental regulatory RNA
chr1_+_171225054 0.07 ENSMUST00000111321.1
ENSMUST00000005824.5
ENSMUST00000111320.1
ENSMUST00000111319.1
apolipoprotein A-II
chr2_+_164486856 0.06 ENSMUST00000109349.2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr6_+_14901440 0.06 ENSMUST00000128567.1
forkhead box P2
chr1_+_24005505 0.06 ENSMUST00000181961.1
predicted gene, 26524
chr4_-_87806296 0.05 ENSMUST00000126353.1
ENSMUST00000149357.1
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr2_+_124610278 0.05 ENSMUST00000051419.8
ENSMUST00000077847.5
ENSMUST00000078621.5
ENSMUST00000076335.5
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr14_-_52213379 0.05 ENSMUST00000140603.1
chromodomain helicase DNA binding protein 8
chr2_-_148046896 0.05 ENSMUST00000172928.1
ENSMUST00000047315.3
forkhead box A2
chrX_+_7878298 0.05 ENSMUST00000033495.8
proviral integration site 2
chr1_-_149922339 0.05 ENSMUST00000111926.2
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr10_+_88201158 0.05 ENSMUST00000171151.2
coiled-coil domain containing 53
chr19_-_28010995 0.05 ENSMUST00000172907.1
ENSMUST00000046898.9
regulatory factor X, 3 (influences HLA class II expression)
chr7_+_24907618 0.05 ENSMUST00000151121.1
Rho guanine nucleotide exchange factor (GEF) 1
chr2_+_164486455 0.05 ENSMUST00000069385.8
ENSMUST00000143690.1
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr16_-_36071515 0.04 ENSMUST00000004057.7
family with sequence similarity 162, member A
chr19_-_28011138 0.04 ENSMUST00000174850.1
regulatory factor X, 3 (influences HLA class II expression)
chr10_+_128303322 0.04 ENSMUST00000005825.6
PAN2 polyA specific ribonuclease subunit homolog (S. cerevisiae)
chr11_-_68386974 0.04 ENSMUST00000135141.1
netrin 1
chr2_+_138278481 0.04 ENSMUST00000075410.4
BTB (POZ) domain containing 3
chr2_+_91710852 0.04 ENSMUST00000128140.1
ENSMUST00000140183.1
harbinger transposase derived 1
chr5_+_66968559 0.03 ENSMUST00000127184.1
LIM and calponin homology domains 1
chr18_-_39489880 0.03 ENSMUST00000152853.1
nuclear receptor subfamily 3, group C, member 1
chr11_+_60353324 0.03 ENSMUST00000070805.6
ENSMUST00000094140.2
ENSMUST00000108723.2
ENSMUST00000108722.4
leucine rich repeat containing 48
chr17_+_24840108 0.02 ENSMUST00000164251.1
hydroxyacyl glutathione hydrolase
chr18_-_39489776 0.02 ENSMUST00000025300.6
nuclear receptor subfamily 3, group C, member 1
chr2_-_7081256 0.02 ENSMUST00000183209.1
CUGBP, Elav-like family member 2
chr19_-_19111181 0.02 ENSMUST00000112832.1
RAR-related orphan receptor beta
chr14_-_121698417 0.02 ENSMUST00000040700.7
dedicator of cytokinesis 9
chr4_+_135728116 0.02 ENSMUST00000102546.3
interleukin 22 receptor, alpha 1
chr11_+_19924403 0.02 ENSMUST00000093298.5
sprouty-related, EVH1 domain containing 2
chr2_-_51973219 0.01 ENSMUST00000028314.2
N-myc (and STAT) interactor
chr9_+_114731177 0.01 ENSMUST00000035007.8
CKLF-like MARVEL transmembrane domain containing 6
chr14_+_84443553 0.01 ENSMUST00000071370.5
protocadherin 17
chr12_-_84194007 0.01 ENSMUST00000110294.1
ELM2 and Myb/SANT-like domain containing 1
chr18_+_20510291 0.01 ENSMUST00000070892.6
desmoglein 3
chrX_+_85574018 0.01 ENSMUST00000048250.3
ENSMUST00000137438.1
ENSMUST00000146063.1
TGF-beta activated kinase 1/MAP3K7 binding protein 3
chr12_-_85270564 0.01 ENSMUST00000019378.6
ENSMUST00000166821.1
mutL homolog 3 (E coli)
chr12_+_72761211 0.01 ENSMUST00000021514.8
protein phosphatase 1A, magnesium dependent, alpha isoform
chr19_-_43986552 0.01 ENSMUST00000026210.4
carboxypeptidase N, polypeptide 1
chr18_-_65393844 0.01 ENSMUST00000035548.8
alpha-kinase 2
chr10_-_49783259 0.00 ENSMUST00000105484.3
ENSMUST00000105486.1
ENSMUST00000079751.2
ENSMUST00000105485.1
glutamate receptor, ionotropic, kainate 2 (beta 2)
chr8_-_122476036 0.00 ENSMUST00000014614.3
ring finger protein 166

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxo3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0061625 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) glycolytic process through fructose-1-phosphate(GO:0061625)
0.2 1.5 GO:0006776 vitamin A metabolic process(GO:0006776)
0.1 0.4 GO:0071492 cellular response to UV-A(GO:0071492)
0.1 0.4 GO:1902732 positive regulation of chondrocyte proliferation(GO:1902732)
0.0 0.3 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.0 0.3 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.0 0.1 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.0 0.2 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0 0.3 GO:0072321 chaperone-mediated protein transport(GO:0072321)
0.0 0.4 GO:0042090 interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.0 0.2 GO:0033600 negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
0.0 0.2 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.0 0.1 GO:0014846 esophagus smooth muscle contraction(GO:0014846) glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.0 0.2 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.0 0.4 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.0 0.1 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
0.0 0.1 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.0 0.2 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0 0.3 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 0.1 GO:0060591 chondroblast differentiation(GO:0060591) positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.0 0.1 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.0 0.1 GO:0002069 columnar/cuboidal epithelial cell maturation(GO:0002069) positive regulation of type B pancreatic cell development(GO:2000078)
0.0 0.1 GO:0051138 positive regulation of NK T cell differentiation(GO:0051138)
0.0 0.1 GO:0045013 carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014)
0.0 0.3 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.1 GO:0090365 regulation of mRNA modification(GO:0090365)
0.0 0.1 GO:1990401 embryonic lung development(GO:1990401)
0.0 0.1 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.0 0.5 GO:0019731 antibacterial humoral response(GO:0019731)
0.0 0.1 GO:0031394 positive regulation of prostaglandin biosynthetic process(GO:0031394) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.1 0.4 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 0.3 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.0 0.3 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 0.2 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 0.2 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.0 GO:0031251 PAN complex(GO:0031251)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 1.5 GO:0019841 retinol binding(GO:0019841)
0.1 0.4 GO:0031720 haptoglobin binding(GO:0031720)
0.1 0.3 GO:0004883 glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.0 0.3 GO:0097001 ceramide binding(GO:0097001)
0.0 0.2 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.0 0.1 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.2 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.0 0.1 GO:0001851 complement component C3b binding(GO:0001851)
0.0 0.1 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.0 0.1 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.0 0.1 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 0.2 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.2 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.1 GO:0003997 acyl-CoA oxidase activity(GO:0003997)
0.0 0.1 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.3 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.3 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 1.5 PID RB 1PATHWAY Regulation of retinoblastoma protein

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.5 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0 0.3 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.9 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.2 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.2 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.1 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.1 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis