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12D miR HR13_24

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Results for Bbx

Z-value: 0.46

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Transcription factors associated with Bbx

Gene Symbol Gene ID Gene Info
ENSMUSG00000022641.9 bobby sox HMG box containing

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Bbxmm10_v2_chr16_-_50432340_50432409-0.633.8e-02Click!

Activity profile of Bbx motif

Sorted Z-values of Bbx motif

Promoter Log-likelihood Transcript Gene Gene Info
chr18_+_37421418 0.52 ENSMUST00000053073.4
protocadherin beta 11
chr13_-_52530827 0.44 ENSMUST00000057442.6
DIRAS family, GTP-binding RAS-like 2
chr2_-_152830266 0.44 ENSMUST00000140436.1
BCL2-like 1
chr2_-_152830615 0.37 ENSMUST00000146380.1
ENSMUST00000134902.1
ENSMUST00000134357.1
ENSMUST00000109820.3
BCL2-like 1
chr6_+_139621888 0.37 ENSMUST00000032353.8
phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide
chr2_+_58754910 0.35 ENSMUST00000059102.6
uridine phosphorylase 2
chr5_-_108675569 0.34 ENSMUST00000051757.7
solute carrier family 26 (sulfate transporter), member 1
chr11_+_59306920 0.34 ENSMUST00000000128.3
ENSMUST00000108783.3
wingless-type MMTV integration site 9A
chr7_+_51880312 0.31 ENSMUST00000145049.1
growth arrest specific 2
chr15_-_3303521 0.29 ENSMUST00000165386.1
coiled-coil domain containing 152
chr1_-_156032948 0.26 ENSMUST00000136397.1
torsin A interacting protein 1
chrX_+_159708593 0.25 ENSMUST00000080394.6
SH3-domain kinase binding protein 1
chr1_-_13660476 0.18 ENSMUST00000027071.5
lactamase, beta 2
chr19_-_11081088 0.16 ENSMUST00000025636.6
membrane-spanning 4-domains, subfamily A, member 8A
chr15_+_21111452 0.13 ENSMUST00000075132.6
cadherin 12
chr10_-_86022325 0.12 ENSMUST00000181665.1
RIKEN cDNA A230060F14 gene
chr10_+_86022189 0.11 ENSMUST00000120344.1
ENSMUST00000117597.1
F-box protein 7
chr7_-_127708886 0.11 ENSMUST00000061468.8
B cell CLL/lymphoma 7C
chr3_-_37232565 0.10 ENSMUST00000161015.1
ENSMUST00000029273.1
interleukin 21
chr8_+_70616816 0.09 ENSMUST00000052437.3
leucine rich repeat containing 25
chr10_+_86021961 0.09 ENSMUST00000130320.1
F-box protein 7
chr12_+_103388656 0.09 ENSMUST00000101094.2
ENSMUST00000021620.6
OTU domain, ubiquitin aldehyde binding 2
chr8_+_45658731 0.07 ENSMUST00000143820.1
ENSMUST00000132139.1
sorbin and SH3 domain containing 2
chr1_+_180111339 0.07 ENSMUST00000145181.1
CDC42 binding protein kinase alpha
chr13_+_49608030 0.06 ENSMUST00000021822.5
osteoglycin
chr8_+_45658666 0.05 ENSMUST00000134675.1
ENSMUST00000139869.1
ENSMUST00000126067.1
sorbin and SH3 domain containing 2
chrX_-_107816238 0.04 ENSMUST00000120722.1
RIKEN cDNA 2610002M06 gene
chr10_-_44458715 0.03 ENSMUST00000039174.4
PR domain containing 1, with ZNF domain
chr8_-_41054771 0.03 ENSMUST00000093534.4
mitochondrial tumor suppressor 1
chr15_-_101892916 0.02 ENSMUST00000100179.1
keratin 76
chr17_+_57358682 0.02 ENSMUST00000086763.5
ENSMUST00000004850.7
EGF-like module containing, mucin-like, hormone receptor-like sequence 1
chr13_-_91807658 0.02 ENSMUST00000022121.6
zinc finger, CCHC domain containing 9
chr3_+_16183177 0.01 ENSMUST00000108345.2
ENSMUST00000108346.2
YTH domain family 3
chr8_+_45658273 0.01 ENSMUST00000153798.1
sorbin and SH3 domain containing 2

Network of associatons between targets according to the STRING database.

First level regulatory network of Bbx

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0046898 response to cycloheximide(GO:0046898)
0.1 0.3 GO:0019532 oxalate transport(GO:0019532)
0.0 0.1 GO:0002370 natural killer cell cytokine production(GO:0002370) regulation of natural killer cell cytokine production(GO:0002727)
0.0 0.3 GO:0071763 nuclear membrane organization(GO:0071763)
0.0 0.2 GO:1903207 neuron death in response to hydrogen peroxide(GO:0036476) regulation of hydrogen peroxide-induced neuron death(GO:1903207) negative regulation of hydrogen peroxide-induced neuron death(GO:1903208)
0.0 0.4 GO:0039703 viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)
0.0 0.3 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.3 GO:0045098 type III intermediate filament(GO:0045098)
0.0 0.2 GO:1990037 Lewy body core(GO:1990037)
0.0 0.4 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0051434 BH3 domain binding(GO:0051434)
0.1 0.3 GO:0004850 uridine phosphorylase activity(GO:0004850)
0.0 0.1 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 0.4 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.3 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.1 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 0.3 GO:0005521 lamin binding(GO:0005521)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.0 0.3 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.4 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.3 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins