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12D miR HR13_24

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Results for Tbx2

Z-value: 0.54

Motif logo

Transcription factors associated with Tbx2

Gene Symbol Gene ID Gene Info
ENSMUSG00000000093.6 T-box 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Tbx2mm10_v2_chr11_+_85832551_85832551-0.107.7e-01Click!

Activity profile of Tbx2 motif

Sorted Z-values of Tbx2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_49549523 1.00 ENSMUST00000029987.9
aldolase B, fructose-bisphosphate
chr1_+_130826762 0.81 ENSMUST00000133792.1
polymeric immunoglobulin receptor
chr1_+_130826676 0.68 ENSMUST00000027675.7
polymeric immunoglobulin receptor
chr7_+_28071230 0.50 ENSMUST00000138392.1
ENSMUST00000076648.7
Fc fragment of IgG binding protein
chr9_-_31464238 0.40 ENSMUST00000048050.7
transmembrane protein 45b
chr19_-_28963863 0.34 ENSMUST00000161813.1
RIKEN cDNA 4430402I18 gene
chr9_-_45204083 0.34 ENSMUST00000034599.8
transmembrane protease, serine 4
chr3_+_60031754 0.33 ENSMUST00000029325.3
arylacetamide deacetylase (esterase)
chr9_+_86743641 0.30 ENSMUST00000179574.1
protease, serine, 35
chr9_+_53850243 0.28 ENSMUST00000048485.5
sarcolipin
chr14_-_30943275 0.28 ENSMUST00000006704.8
ENSMUST00000163118.1
inter-alpha trypsin inhibitor, heavy chain 1
chr11_-_69900930 0.28 ENSMUST00000018714.6
ENSMUST00000128046.1
RIKEN cDNA 2810408A11 gene
chr10_+_79890853 0.27 ENSMUST00000061653.7
complement factor D (adipsin)
chr3_-_107943705 0.26 ENSMUST00000106680.1
ENSMUST00000106684.1
ENSMUST00000106685.2
glutathione S-transferase, mu 6
chr9_+_86743616 0.23 ENSMUST00000036426.6
protease, serine, 35
chr9_-_95845215 0.22 ENSMUST00000093800.2
plastin 1 (I-isoform)
chr4_+_148000722 0.22 ENSMUST00000103230.4
natriuretic peptide type A
chr2_+_54436317 0.22 ENSMUST00000112636.1
ENSMUST00000112635.1
ENSMUST00000112634.1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13
chr7_-_28302238 0.21 ENSMUST00000108315.3
delta-like 3 (Drosophila)
chr2_+_10047838 0.21 ENSMUST00000181588.1
RIKEN cDNA C630004M23 gene
chr6_+_15196949 0.20 ENSMUST00000151301.1
ENSMUST00000131414.1
ENSMUST00000140557.1
ENSMUST00000115469.1
forkhead box P2
chr2_-_164828529 0.20 ENSMUST00000017911.3
spermatogenesis associated 25
chr9_-_110645328 0.19 ENSMUST00000149089.1
neurobeachin-like 2
chr6_-_122609964 0.19 ENSMUST00000032211.4
growth differentiation factor 3
chr1_-_63273112 0.19 ENSMUST00000153049.1
ENSMUST00000151616.1
predicted gene 11608
chr11_-_69900949 0.19 ENSMUST00000102580.3
RIKEN cDNA 2810408A11 gene
chr4_+_84884366 0.18 ENSMUST00000102819.3
centlein, centrosomal protein
chr6_+_116264186 0.18 ENSMUST00000036503.7
ENSMUST00000112900.3
zinc finger, AN1-type domain 4
chr4_-_41464816 0.17 ENSMUST00000108055.2
ENSMUST00000154535.1
ENSMUST00000030148.5
kinesin family member 24
chr5_+_108065696 0.16 ENSMUST00000172045.1
metal response element binding transcription factor 2
chr13_-_100316616 0.16 ENSMUST00000042220.2
NLR family, apoptosis inhibitory protein 6
chr3_-_127499095 0.15 ENSMUST00000182594.1
ankyrin 2, brain
chr14_+_68083853 0.15 ENSMUST00000022639.7
neurofilament, light polypeptide
chr9_-_123678782 0.15 ENSMUST00000170591.1
ENSMUST00000171647.1
solute carrier family 6 (neurotransmitter transporter), member 20A
chr13_-_103096818 0.14 ENSMUST00000166336.1
microtubule associated serine/threonine kinase family member 4
chr1_-_105356658 0.14 ENSMUST00000058688.5
ENSMUST00000172299.1
ring finger protein 152
chr1_+_131599239 0.13 ENSMUST00000027690.6
arginine vasopressin receptor 1B
chr16_-_43979050 0.12 ENSMUST00000165648.1
ENSMUST00000036321.7
zinc finger, DHHC domain containing 23
chr4_+_42035113 0.12 ENSMUST00000098127.1
predicted gene 10597
chr15_-_95528702 0.11 ENSMUST00000166170.1
NEL-like 2
chr4_+_84884418 0.11 ENSMUST00000169371.2
centlein, centrosomal protein
chr19_-_37207293 0.11 ENSMUST00000132580.1
ENSMUST00000079754.4
ENSMUST00000136286.1
ENSMUST00000126188.1
ENSMUST00000126781.1
cytoplasmic polyadenylation element binding protein 3
chr13_+_13590402 0.11 ENSMUST00000110559.1
lysosomal trafficking regulator
chr9_+_54980880 0.10 ENSMUST00000093844.3
cholinergic receptor, nicotinic, alpha polypeptide 5
chr12_-_41485751 0.10 ENSMUST00000043884.4
leucine rich repeat protein 3, neuronal
chr15_-_95528228 0.10 ENSMUST00000075275.2
NEL-like 2
chr1_+_63273261 0.10 ENSMUST00000114132.1
ENSMUST00000126932.1
zinc finger, DBF-type containing 2
chr11_-_84068766 0.10 ENSMUST00000018792.5
dual specificity phosphatase 14
chr4_+_84884276 0.09 ENSMUST00000047023.6
centlein, centrosomal protein
chr3_+_96680093 0.09 ENSMUST00000130429.1
ankyrin repeat domain 35
chr6_-_116716888 0.09 ENSMUST00000056623.6
transmembrane protein 72
chr16_-_32797413 0.09 ENSMUST00000115116.1
ENSMUST00000041123.8
mucin 20
chrX_+_153006461 0.08 ENSMUST00000095755.3
ubiquitin specific protease 51
chr2_+_172979827 0.08 ENSMUST00000109125.1
ENSMUST00000050442.9
ENSMUST00000109126.3
SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae)
chr9_-_49798905 0.08 ENSMUST00000114476.2
neural cell adhesion molecule 1
chr2_+_175372436 0.08 ENSMUST00000131676.1
ENSMUST00000109048.2
ENSMUST00000109047.2
predicted gene 4723
chr11_+_98551097 0.08 ENSMUST00000081033.6
ENSMUST00000107511.1
ENSMUST00000107509.1
ENSMUST00000017339.5
zona pellucida binding protein 2
chr7_+_50599180 0.07 ENSMUST00000119710.2
RIKEN cDNA 4933405O20 gene
chr2_-_60673654 0.07 ENSMUST00000059888.8
ENSMUST00000154764.1
integrin beta 6
chr2_-_91183017 0.07 ENSMUST00000066420.5
MAP-kinase activating death domain
chr14_+_80000292 0.07 ENSMUST00000088735.3
olfactomedin 4
chr11_+_70639118 0.07 ENSMUST00000055184.6
ENSMUST00000108551.2
glycoprotein 1b, alpha polypeptide
chr11_-_84068357 0.07 ENSMUST00000100705.4
dual specificity phosphatase 14
chr7_+_25267669 0.06 ENSMUST00000169266.1
capicua homolog (Drosophila)
chr11_-_101551837 0.06 ENSMUST00000017290.4
breast cancer 1
chr11_+_98551173 0.06 ENSMUST00000107513.2
zona pellucida binding protein 2
chrX_-_95444789 0.06 ENSMUST00000084535.5
APC membrane recruitment 1
chr13_+_118714678 0.06 ENSMUST00000022246.8
fibroblast growth factor 10
chr1_+_66468364 0.06 ENSMUST00000061620.9
unc-80 homolog (C. elegans)
chr2_-_175703646 0.06 ENSMUST00000109027.2
ENSMUST00000179061.1
ENSMUST00000131041.1
predicted gene 4245
chrX_+_139210031 0.06 ENSMUST00000113043.1
ENSMUST00000169886.1
ENSMUST00000113045.2
melanoma associated antigen (mutated) 1-like 1
chr1_-_172082757 0.05 ENSMUST00000003550.4
nicastrin
chr2_+_152081529 0.05 ENSMUST00000064061.3
scratch homolog 2, zinc finger protein (Drosophila)
chr2_+_68861564 0.05 ENSMUST00000176018.1
ceramide synthase 6
chr7_-_115824699 0.05 ENSMUST00000169129.1
SRY-box containing gene 6
chr4_+_116221590 0.05 ENSMUST00000147292.1
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
chr7_-_108930151 0.05 ENSMUST00000055745.3
NLR family, pyrin domain containing 10
chr4_+_53440388 0.05 ENSMUST00000102911.3
ENSMUST00000107646.2
solute carrier family 44, member 1
chr2_+_68861433 0.05 ENSMUST00000028426.2
ceramide synthase 6
chrX_+_100729917 0.05 ENSMUST00000019503.7
glycerophosphodiester phosphodiesterase domain containing 2
chr17_+_3397189 0.05 ENSMUST00000072156.6
T cell lymphoma invasion and metastasis 2
chr4_+_42950369 0.05 ENSMUST00000084662.5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr4_+_11191726 0.05 ENSMUST00000029866.9
ENSMUST00000108324.3
cyclin E2
chr5_+_108065742 0.04 ENSMUST00000081567.4
ENSMUST00000170319.1
ENSMUST00000112626.1
metal response element binding transcription factor 2
chr3_+_96104498 0.04 ENSMUST00000132980.1
ENSMUST00000138206.1
ENSMUST00000090785.2
ENSMUST00000035519.5
OTU domain containing 7B
chr7_+_3645267 0.04 ENSMUST00000038913.9
CCR4-NOT transcription complex, subunit 3
chr9_-_49798729 0.04 ENSMUST00000166811.2
neural cell adhesion molecule 1
chr6_+_42286709 0.04 ENSMUST00000163936.1
chloride channel 1
chr5_+_120513102 0.04 ENSMUST00000111889.1
solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
chr7_+_133637686 0.04 ENSMUST00000128901.2
RIKEN cDNA 2700050L05 gene
chr2_+_175469985 0.04 ENSMUST00000109042.3
ENSMUST00000109002.2
ENSMUST00000109043.2
ENSMUST00000143490.1
predicted gene 8923
chr19_-_45046614 0.04 ENSMUST00000145391.1
PDZ domain containing 7
chr8_-_122476036 0.03 ENSMUST00000014614.3
ring finger protein 166
chr17_-_42611313 0.03 ENSMUST00000068355.6
opsin 5
chr13_+_112464070 0.03 ENSMUST00000183663.1
ENSMUST00000184311.1
ENSMUST00000183886.1
interleukin 6 signal transducer
chr2_+_54436432 0.03 ENSMUST00000136642.1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13
chr16_-_32868325 0.03 ENSMUST00000089684.3
ENSMUST00000040986.8
ENSMUST00000115105.2
RIKEN cDNA 1700021K19 gene
chrX_+_169685191 0.03 ENSMUST00000112104.1
ENSMUST00000112107.1
midline 1
chr10_+_106470281 0.03 ENSMUST00000029404.9
ENSMUST00000169303.1
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr7_+_27607997 0.03 ENSMUST00000142365.1
thymoma viral proto-oncogene 2
chr11_+_96316684 0.03 ENSMUST00000049241.7
homeobox B4
chr7_+_111028951 0.02 ENSMUST00000005749.5
Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr11_-_23895208 0.02 ENSMUST00000102863.2
ENSMUST00000020513.3
poly(A) polymerase gamma
chr3_+_32436376 0.02 ENSMUST00000108242.1
phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
chr13_+_93308006 0.02 ENSMUST00000079086.6
homer homolog 1 (Drosophila)
chr6_-_94700137 0.02 ENSMUST00000101126.2
ENSMUST00000032105.4
leucine-rich repeats and immunoglobulin-like domains 1
chr1_+_131970589 0.02 ENSMUST00000027695.6
solute carrier family 45, member 3
chr15_+_92344359 0.02 ENSMUST00000181901.1
predicted gene, 26760
chr13_-_100246323 0.02 ENSMUST00000049789.2
NLR family, apoptosis inhibitory protein 5
chrX_-_139782353 0.02 ENSMUST00000101217.3
ripply1 homolog (zebrafish)
chr11_+_69901816 0.02 ENSMUST00000177138.1
ENSMUST00000108617.3
ENSMUST00000177476.1
ENSMUST00000061837.4
neuralized homolog 4 (Drosophila)
chr19_+_4003334 0.02 ENSMUST00000025806.3
double C2, gamma
chr2_-_114052804 0.02 ENSMUST00000090269.6
actin, alpha, cardiac muscle 1
chr2_-_91182848 0.02 ENSMUST00000111370.2
ENSMUST00000111376.1
ENSMUST00000099723.2
MAP-kinase activating death domain
chr2_-_121085835 0.02 ENSMUST00000028721.7
transglutaminase 5
chr4_+_116221689 0.02 ENSMUST00000106490.2
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
chr3_+_36552600 0.01 ENSMUST00000029269.5
ENSMUST00000136890.1
exosome component 9
chr9_+_19641224 0.01 ENSMUST00000079042.6
zinc finger protein 317
chr17_-_46680870 0.01 ENSMUST00000165007.1
ENSMUST00000071841.5
kelch domain containing 3
chr1_+_170214826 0.01 ENSMUST00000159201.1
ENSMUST00000055830.1
RIKEN cDNA 4930500M09 gene
chr5_-_137533170 0.01 ENSMUST00000168746.1
ENSMUST00000170293.1
guanine nucleotide binding protein (G protein), beta 2
chr19_-_10304867 0.01 ENSMUST00000039327.4
diacylglycerol lipase, alpha
chr9_+_73044833 0.01 ENSMUST00000184146.1
ENSMUST00000034722.4
RAB27A, member RAS oncogene family
chr9_-_22131801 0.01 ENSMUST00000069330.6
acid phosphatase 5, tartrate resistant
chr5_-_108132513 0.01 ENSMUST00000119784.1
ENSMUST00000117759.1
transmembrane emp24 protein transport domain containing 5
chr15_+_61987034 0.01 ENSMUST00000159338.1
myelocytomatosis oncogene
chr2_+_124089961 0.01 ENSMUST00000103241.1
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr6_-_28261907 0.01 ENSMUST00000115320.1
ENSMUST00000123098.1
ENSMUST00000115321.2
ENSMUST00000155494.1
zinc finger protein 800
chr13_+_65152226 0.01 ENSMUST00000058907.3
olfactory receptor 466
chr5_-_108132541 0.01 ENSMUST00000119437.1
ENSMUST00000118036.1
transmembrane emp24 protein transport domain containing 5
chr4_-_58499398 0.01 ENSMUST00000107570.1
lysophosphatidic acid receptor 1
chr8_+_107119110 0.01 ENSMUST00000046116.1
RIKEN cDNA C630050I24 gene
chr1_-_173741717 0.01 ENSMUST00000127730.1
expressed sequence AI607873
chr2_+_52857844 0.00 ENSMUST00000090952.4
ENSMUST00000049483.6
ENSMUST00000050719.6
formin-like 2
chr11_+_103101682 0.00 ENSMUST00000107040.3
ENSMUST00000140372.1
ENSMUST00000024492.8
ENSMUST00000134884.1
acyl-Coenzyme A binding domain containing 4
chr15_+_6445320 0.00 ENSMUST00000022749.9
complement component 9
chr13_-_43304153 0.00 ENSMUST00000055341.5
glucose-fructose oxidoreductase domain containing 1
chr1_-_52500679 0.00 ENSMUST00000069792.7
Ngfi-A binding protein 1
chr11_+_23306910 0.00 ENSMUST00000137823.1
ubiquitin specific peptidase 34
chr4_+_94614483 0.00 ENSMUST00000030311.4
ENSMUST00000107104.2
intraflagellar transport 74
chr7_+_29309429 0.00 ENSMUST00000137848.1
D4, zinc and double PHD fingers family 1
chr18_+_55057557 0.00 ENSMUST00000181765.1
predicted gene 4221
chr4_-_129573637 0.00 ENSMUST00000102596.1
lymphocyte protein tyrosine kinase

Network of associatons between targets according to the STRING database.

First level regulatory network of Tbx2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.5 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.2 1.0 GO:0061624 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) glycolytic process through fructose-1-phosphate(GO:0061625)
0.1 0.2 GO:1902896 terminal web assembly(GO:1902896)
0.0 0.1 GO:0033693 neurofilament bundle assembly(GO:0033693)
0.0 0.2 GO:0070889 platelet alpha granule organization(GO:0070889)
0.0 0.3 GO:1901894 regulation of calcium-transporting ATPase activity(GO:1901894)
0.0 0.2 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.0 0.2 GO:0007386 compartment pattern specification(GO:0007386)
0.0 0.2 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.0 0.1 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.0 0.1 GO:1900247 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.0 0.1 GO:0035524 proline transmembrane transport(GO:0035524)
0.0 0.1 GO:0001992 regulation of systemic arterial blood pressure by vasopressin(GO:0001992)
0.0 0.3 GO:0010898 positive regulation of triglyceride catabolic process(GO:0010898)
0.0 0.1 GO:1902277 negative regulation of pancreatic amylase secretion(GO:1902277)
0.0 0.1 GO:1990918 double-strand break repair involved in meiotic recombination(GO:1990918)
0.0 0.1 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.0 0.4 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.0 0.2 GO:0048859 formation of anatomical boundary(GO:0048859)
0.0 0.1 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
0.0 0.1 GO:0060435 bronchiole development(GO:0060435) secretion by lung epithelial cell involved in lung growth(GO:0061033) white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350) positive regulation of hair follicle cell proliferation(GO:0071338)
0.0 0.3 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.2 GO:0036309 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) regulation of SA node cell action potential(GO:0098907)
0.0 0.2 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.0 0.2 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.0 0.2 GO:0070269 pyroptosis(GO:0070269)
0.0 0.0 GO:0070104 negative regulation of interleukin-6-mediated signaling pathway(GO:0070104)
0.0 0.1 GO:0038044 transforming growth factor-beta secretion(GO:0038044)
0.0 0.1 GO:2001012 mesenchymal cell differentiation involved in kidney development(GO:0072161) mesenchymal cell differentiation involved in renal system development(GO:2001012)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0 0.1 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.0 1.5 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.5 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.2 GO:1990357 terminal web(GO:1990357)
0.0 0.2 GO:0072557 IPAF inflammasome complex(GO:0072557)
0.0 0.1 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
0.0 0.2 GO:0042629 mast cell granule(GO:0042629)
0.0 0.0 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.0 0.3 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.0 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.0 0.1 GO:0070531 BRCA1-A complex(GO:0070531)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.5 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.1 1.0 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.1 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.0 0.3 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.1 GO:0005000 vasopressin receptor activity(GO:0005000)
0.0 0.1 GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0 0.1 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.0 0.3 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.0 GO:0005502 11-cis retinal binding(GO:0005502)
0.0 0.0 GO:0004923 interleukin-6 receptor activity(GO:0004915) leukemia inhibitory factor receptor activity(GO:0004923) interleukin-6 binding(GO:0019981)
0.0 0.2 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 0.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.1 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.3 PID IL4 2PATHWAY IL4-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.3 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.0 0.1 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors