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12D miR HR13_24

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Results for Cdx2

Z-value: 0.88

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Transcription factors associated with Cdx2

Gene Symbol Gene ID Gene Info
ENSMUSG00000029646.3 caudal type homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Cdx2mm10_v2_chr5_-_147307264_147307281-0.576.8e-02Click!

Activity profile of Cdx2 motif

Sorted Z-values of Cdx2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr16_-_44016387 2.32 ENSMUST00000036174.3
GRAM domain containing 1C
chr4_-_137118135 1.79 ENSMUST00000154285.1
predicted gene 13001
chr2_-_24048857 1.44 ENSMUST00000114497.1
histamine N-methyltransferase
chr13_+_89540636 1.39 ENSMUST00000022108.7
hyaluronan and proteoglycan link protein 1
chr9_-_21989427 1.24 ENSMUST00000045726.6
ral guanine nucleotide dissociation stimulator-like 3
chr19_-_34879452 1.18 ENSMUST00000036584.5
pantothenate kinase 1
chrX_+_164140447 1.07 ENSMUST00000073973.4
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr6_+_71199827 0.96 ENSMUST00000067492.7
fatty acid binding protein 1, liver
chr11_-_99979053 0.94 ENSMUST00000105051.1
keratin associated protein 29-1
chrX_+_139684980 0.88 ENSMUST00000096313.3
TBC1 domain family, member 8B
chr17_-_90088343 0.81 ENSMUST00000173917.1
neurexin I
chr17_-_91092715 0.75 ENSMUST00000160800.2
ENSMUST00000159778.1
ENSMUST00000160844.3
neurexin I
chr3_+_40540751 0.73 ENSMUST00000091186.3
inturned planar cell polarity effector homolog (Drosophila)
chr7_+_131032061 0.72 ENSMUST00000084509.3
deleted in malignant brain tumors 1
chr6_-_13839916 0.66 ENSMUST00000060442.7
G protein-coupled receptor 85
chr11_-_99244058 0.63 ENSMUST00000103132.3
ENSMUST00000038214.6
keratin 222
chr1_+_109993982 0.58 ENSMUST00000027542.6
cadherin 7, type 2
chr11_-_99993992 0.56 ENSMUST00000105049.1
keratin associated protein 17-1
chr11_+_87663087 0.56 ENSMUST00000165679.1
ring finger protein 43
chr3_-_90695706 0.53 ENSMUST00000069960.5
ENSMUST00000117167.1
S100 calcium binding protein A9 (calgranulin B)
chr1_-_169747634 0.53 ENSMUST00000027991.5
ENSMUST00000111357.1
regulator of G-protein signaling 4
chr3_+_126597415 0.53 ENSMUST00000066452.7
ENSMUST00000171289.1
ENSMUST00000106399.1
calcium/calmodulin-dependent protein kinase II, delta
chr8_-_105933832 0.48 ENSMUST00000034368.6
chymotrypsin-like
chr10_+_52391606 0.48 ENSMUST00000067085.4
nephrocan
chr5_+_13399309 0.46 ENSMUST00000030714.7
ENSMUST00000141968.1
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr4_-_64046925 0.41 ENSMUST00000107377.3
tenascin C
chr8_+_54550324 0.41 ENSMUST00000033918.2
ankyrin repeat and SOCs box-containing 5
chr3_+_3634145 0.40 ENSMUST00000108394.1
hepatocyte nuclear factor 4, gamma
chrX_-_51205990 0.39 ENSMUST00000114876.2
muscleblind-like 3 (Drosophila)
chr18_+_37755718 0.36 ENSMUST00000061279.7
protocadherin gamma subfamily A, 9
chr13_-_23934156 0.35 ENSMUST00000052776.2
histone cluster 1, H2ba
chr5_-_135744206 0.34 ENSMUST00000153399.1
ENSMUST00000043378.2
transmembrane protein 120A
chr19_+_8850785 0.33 ENSMUST00000096257.2
LRRN4 C-terminal like
chr12_+_77238093 0.33 ENSMUST00000177595.1
ENSMUST00000171770.2
fucosyltransferase 8
chr3_+_126597299 0.33 ENSMUST00000106400.2
ENSMUST00000106401.1
calcium/calmodulin-dependent protein kinase II, delta
chr14_+_80000292 0.32 ENSMUST00000088735.3
olfactomedin 4
chr4_+_144893127 0.32 ENSMUST00000142808.1
dehydrogenase/reductase (SDR family) member 3
chr14_+_54686171 0.30 ENSMUST00000038539.6
RIKEN cDNA 1700123O20 gene
chr10_+_118204942 0.26 ENSMUST00000096691.4
interleukin 22
chr1_-_89933290 0.26 ENSMUST00000036954.7
gastrulation brain homeobox 2
chr3_-_92485886 0.23 ENSMUST00000054599.7
small proline-rich protein 1A
chr15_-_101491509 0.20 ENSMUST00000023718.7
RIKEN cDNA 5430421N21 gene
chr10_-_34044302 0.19 ENSMUST00000048052.5
family with sequence similarity 26, member D
chr1_+_12692430 0.18 ENSMUST00000180062.1
ENSMUST00000177608.1
sulfatase 1
chr11_-_99438143 0.16 ENSMUST00000017743.2
keratin 20
chr17_+_80307396 0.15 ENSMUST00000068175.5
Rho guanine nucleotide exchange factor (GEF) 33
chr12_+_113074756 0.15 ENSMUST00000109729.2
testis expressed gene 22
chr1_-_186705980 0.14 ENSMUST00000045288.8
transforming growth factor, beta 2
chr13_-_107890059 0.14 ENSMUST00000105097.2
zinc finger SWIM-type containing 6
chr1_-_144249134 0.14 ENSMUST00000172388.1
regulator of G-protein signaling 1
chr2_+_74721978 0.13 ENSMUST00000047904.3
homeobox D3
chr6_+_17491216 0.11 ENSMUST00000080469.5
met proto-oncogene
chr2_+_4300462 0.11 ENSMUST00000175669.1
FERM domain containing 4A
chr15_-_101573883 0.10 ENSMUST00000042957.5
keratin 75
chr19_-_47692042 0.09 ENSMUST00000026045.7
ENSMUST00000086923.5
collagen, type XVII, alpha 1
chr8_+_94386486 0.09 ENSMUST00000034220.7
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chrX_+_164090187 0.08 ENSMUST00000015545.3
transmembrane protein 27
chr12_+_113074475 0.07 ENSMUST00000012355.7
ENSMUST00000146107.1
testis expressed gene 22
chr4_-_109202217 0.06 ENSMUST00000160774.1
ENSMUST00000030288.7
ENSMUST00000162787.2
oxysterol binding protein-like 9
chr2_-_64393853 0.05 ENSMUST00000142353.1
predicted gene 13575
chr6_-_71262232 0.04 ENSMUST00000129630.2
ENSMUST00000114186.2
ENSMUST00000074301.3
SET and MYND domain containing 1
chr8_+_94386438 0.04 ENSMUST00000161576.1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr18_+_37513652 0.04 ENSMUST00000061405.4
protocadherin beta 21
chr16_-_79091078 0.04 ENSMUST00000023566.4
ENSMUST00000060402.5
transmembrane protease, serine 15
chr8_+_15057646 0.03 ENSMUST00000033842.3
myomesin 2
chr18_+_65582281 0.03 ENSMUST00000183319.1
zinc finger protein 532
chr15_+_23036449 0.02 ENSMUST00000164787.1
cadherin 18
chr6_-_122340525 0.02 ENSMUST00000112600.2
polyhomeotic-like 1 (Drosophila)
chr5_+_90460889 0.01 ENSMUST00000031314.8
albumin
chr6_+_38918969 0.01 ENSMUST00000003017.6
thromboxane A synthase 1, platelet
chr3_-_142169196 0.00 ENSMUST00000098568.1
bone morphogenetic protein receptor, type 1B

Network of associatons between targets according to the STRING database.

First level regulatory network of Cdx2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.6 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.4 1.4 GO:0001692 histamine metabolic process(GO:0001692)
0.3 1.1 GO:0015801 aromatic amino acid transport(GO:0015801) tryptophan transport(GO:0015827)
0.2 0.5 GO:0070488 neutrophil aggregation(GO:0070488)
0.1 0.9 GO:0035022 positive regulation of Rac protein signal transduction(GO:0035022)
0.1 0.5 GO:0021828 cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) facioacoustic ganglion development(GO:1903375)
0.1 0.4 GO:0060447 peripheral nervous system axon regeneration(GO:0014012) bud outgrowth involved in lung branching(GO:0060447)
0.1 0.6 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.1 0.3 GO:0046368 GDP-L-fucose metabolic process(GO:0046368)
0.1 1.2 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.1 1.0 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.1 0.7 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.0 0.1 GO:0003275 endocardial cushion fusion(GO:0003274) apoptotic process involved in outflow tract morphogenesis(GO:0003275) regulation of catagen(GO:0051794) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256)
0.0 0.2 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.0 0.3 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.0 0.7 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.0 0.3 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.0 0.1 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.0 0.3 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.1 GO:0070495 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.0 0.2 GO:0031424 keratinization(GO:0031424)
0.0 1.0 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 0.4 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.1 1.6 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 1.0 GO:0045179 apical cortex(GO:0045179)
0.0 1.0 GO:0045095 keratin filament(GO:0045095)
0.0 0.9 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.1 GO:1990037 Lewy body core(GO:1990037)
0.0 0.3 GO:0042581 specific granule(GO:0042581)
0.0 0.3 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.7 GO:0043194 axon initial segment(GO:0043194)
0.0 0.2 GO:0001533 cornified envelope(GO:0001533)
0.0 1.2 GO:0030118 clathrin coat(GO:0030118)
0.0 0.8 GO:0005882 intermediate filament(GO:0005882)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:0004594 pantothenate kinase activity(GO:0004594)
0.2 1.2 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.2 1.1 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.1 1.0 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.1 1.6 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 0.9 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.1 0.2 GO:0030280 structural constituent of epidermis(GO:0030280)
0.1 0.5 GO:0050786 Toll-like receptor 4 binding(GO:0035662) RAGE receptor binding(GO:0050786)
0.1 1.4 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 0.4 GO:0045545 syndecan binding(GO:0045545)
0.0 0.3 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.1 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.0 0.2 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.5 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.3 GO:0008417 fucosyltransferase activity(GO:0008417)
0.0 0.1 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.0 0.8 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 1.2 GO:0008170 N-methyltransferase activity(GO:0008170)
0.0 0.7 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.6 GO:0005109 frizzled binding(GO:0005109)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.4 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.9 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.5 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.4 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.1 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.9 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 0.5 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.6 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.9 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.3 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0 0.4 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells