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12D miR HR13_24

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Results for Mecom

Z-value: 0.78

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Transcription factors associated with Mecom

Gene Symbol Gene ID Gene Info
ENSMUSG00000027684.10 MDS1 and EVI1 complex locus

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Mecommm10_v2_chr3_-_30509752_305098220.382.5e-01Click!

Activity profile of Mecom motif

Sorted Z-values of Mecom motif

Promoter Log-likelihood Transcript Gene Gene Info
chrX_+_11305655 0.83 ENSMUST00000178806.1
predicted gene 14477
chrX_+_11315158 0.82 ENSMUST00000179004.1
predicted gene 14479
chrX_+_11324659 0.82 ENSMUST00000164729.2
predicted gene 14475
chrX_+_11308824 0.82 ENSMUST00000178595.1
predicted gene 14476
chrX_+_11318256 0.69 ENSMUST00000179859.1
predicted gene 14482
chrX_+_11321423 0.67 ENSMUST00000178196.1
predicted gene 14478
chrX_+_9283764 0.63 ENSMUST00000177926.1
RIKEN cDNA 1700012L04 gene
chrX_+_11299257 0.62 ENSMUST00000178729.1
predicted gene 14483
chrX_+_11302432 0.60 ENSMUST00000179428.1
predicted gene 14474
chrX_+_11311934 0.59 ENSMUST00000178979.1
predicted gene 14484
chr1_+_156838915 0.54 ENSMUST00000111720.1
angiopoietin-like 1
chrX_+_9350599 0.49 ENSMUST00000073949.2
predicted gene 14501
chr1_+_152399824 0.43 ENSMUST00000044311.8
collagen beta(1-O)galactosyltransferase 2
chr1_+_120006980 0.42 ENSMUST00000072886.4
secretin receptor
chr2_+_103970115 0.37 ENSMUST00000111143.1
ENSMUST00000138815.1
LIM domain only 2
chr2_+_71786923 0.34 ENSMUST00000112101.1
ENSMUST00000028522.3
integrin alpha 6
chr2_+_103969528 0.33 ENSMUST00000123437.1
ENSMUST00000163256.1
LIM domain only 2
chrX_+_98149666 0.32 ENSMUST00000052837.7
androgen receptor
chr7_+_127296291 0.30 ENSMUST00000106306.2
ENSMUST00000120857.1
integrin alpha L
chr13_+_49544443 0.27 ENSMUST00000177948.1
ENSMUST00000021820.6
asporin
chr2_-_152830266 0.26 ENSMUST00000140436.1
BCL2-like 1
chr16_+_56477838 0.26 ENSMUST00000048471.7
ENSMUST00000096013.3
ENSMUST00000096012.3
ENSMUST00000171000.1
ABI gene family, member 3 (NESH) binding protein
chr10_-_27616895 0.25 ENSMUST00000092639.5
laminin, alpha 2
chr14_+_34375504 0.24 ENSMUST00000111908.1
multimerin 2
chr2_+_97467657 0.22 ENSMUST00000059049.7
leucine rich repeat containing 4C
chr3_+_87357874 0.21 ENSMUST00000015998.6
CD5 antigen-like
chr10_+_63457505 0.20 ENSMUST00000105440.1
catenin (cadherin associated protein), alpha 3
chrX_-_145505136 0.19 ENSMUST00000112835.1
angiomotin
chr2_+_103970221 0.19 ENSMUST00000111140.2
ENSMUST00000111139.2
LIM domain only 2
chr1_-_173766876 0.18 ENSMUST00000111214.2
interferon activated gene 204
chr14_+_61599493 0.17 ENSMUST00000039562.6
tripartite motif-containing 13
chr13_+_89540636 0.16 ENSMUST00000022108.7
hyaluronan and proteoglycan link protein 1
chr2_-_149798701 0.15 ENSMUST00000148202.1
ENSMUST00000139471.1
predicted gene 14133
chr14_-_43875517 0.14 ENSMUST00000179200.1
eosinophil-associated, ribonuclease A family, member 1
chr5_-_120467296 0.13 ENSMUST00000132916.1
serine dehydratase-like
chr10_+_3740348 0.13 ENSMUST00000120274.1
pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr7_+_82337218 0.13 ENSMUST00000173828.1
ADAMTS-like 3
chr2_-_45110241 0.13 ENSMUST00000177302.1
zinc finger E-box binding homeobox 2
chrX_-_139871637 0.13 ENSMUST00000033811.7
ENSMUST00000087401.5
microrchidia 4
chr7_+_127296251 0.12 ENSMUST00000117762.1
integrin alpha L
chr12_-_11208948 0.12 ENSMUST00000049877.1
mesogenin 1
chr16_-_48771956 0.12 ENSMUST00000170861.1
T cell receptor associated transmembrane adaptor 1
chr17_-_32420965 0.11 ENSMUST00000170392.1
peptidoglycan recognition protein 2
chr16_-_29541483 0.11 ENSMUST00000057018.8
ENSMUST00000182627.1
ATPase type 13A4
chr2_+_34874486 0.11 ENSMUST00000028228.3
cutA divalent cation tolerance homolog-like
chr1_+_107511416 0.09 ENSMUST00000009356.4
serine (or cysteine) peptidase inhibitor, clade B, member 2
chrX_+_169879596 0.09 ENSMUST00000112105.1
ENSMUST00000078947.5
midline 1
chr2_+_34874396 0.09 ENSMUST00000113068.2
ENSMUST00000047447.8
cutA divalent cation tolerance homolog-like
chr10_+_5593718 0.09 ENSMUST00000051809.8
myc target 1
chr8_+_12385769 0.07 ENSMUST00000080795.8
predicted gene 5607
chr1_+_107511489 0.07 ENSMUST00000064916.2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr6_+_129397297 0.06 ENSMUST00000032262.7
C-type lectin domain family 1, member b
chr16_-_38713235 0.06 ENSMUST00000023487.4
Rho GTPase activating protein 31
chr1_-_189343342 0.06 ENSMUST00000079451.6
potassium channel, subfamily K, member 2
chrX_-_37110257 0.06 ENSMUST00000076265.6
UPF3 regulator of nonsense transcripts homolog B (yeast)
chr2_-_45110336 0.05 ENSMUST00000028229.6
ENSMUST00000152232.1
zinc finger E-box binding homeobox 2
chr18_+_80206775 0.05 ENSMUST00000145963.1
ENSMUST00000025464.7
ENSMUST00000125127.1
ENSMUST00000025463.7
thioredoxin-like 4A
predicted gene 16286
chr6_-_29609811 0.05 ENSMUST00000012679.8
transportin 3
chr11_-_88718078 0.04 ENSMUST00000092794.5
musashi RNA-binding protein 2
chr14_+_55853997 0.04 ENSMUST00000100529.3
NYN domain and retroviral integrase containing
chr6_-_29609607 0.04 ENSMUST00000115251.1
transportin 3
chr14_+_115042752 0.04 ENSMUST00000134140.2
Mir17 host gene 1 (non-protein coding)
chr2_+_18672384 0.04 ENSMUST00000171845.1
ENSMUST00000061158.4
COMM domain containing 3
chr14_+_55854115 0.04 ENSMUST00000168479.1
NYN domain and retroviral integrase containing
chr17_+_33432890 0.04 ENSMUST00000174088.2
actin-like 9
chr6_+_138140298 0.04 ENSMUST00000008684.4
microsomal glutathione S-transferase 1
chr6_-_30958990 0.04 ENSMUST00000101589.3
Kruppel-like factor 14
chr9_+_72806874 0.03 ENSMUST00000055535.8
protogenin homolog (Gallus gallus)
chr9_-_35611915 0.03 ENSMUST00000034610.2
prostate and testis expressed 4
chr15_-_48791933 0.03 ENSMUST00000160658.1
ENSMUST00000100670.3
ENSMUST00000162830.1
CUB and Sushi multiple domains 3
chr11_-_81968415 0.02 ENSMUST00000066197.6
acid-sensing (proton-gated) ion channel 2
chr17_-_37086236 0.02 ENSMUST00000070808.2
olfactory receptor 90
chr18_+_80206887 0.02 ENSMUST00000127234.1
predicted gene 16286
chr11_-_83020722 0.02 ENSMUST00000108152.2
schlafen 8
chrX_-_113185485 0.02 ENSMUST00000026607.8
ENSMUST00000113388.2
choroidermia
chr14_-_124677089 0.02 ENSMUST00000095529.3
fibroblast growth factor 14
chr5_+_129715488 0.02 ENSMUST00000119576.1
ENSMUST00000042191.5
ENSMUST00000118420.1
ENSMUST00000154358.1
ENSMUST00000121339.1
ENSMUST00000119604.1
ENSMUST00000136108.1
ENSMUST00000121813.1
ENSMUST00000119985.1
ENSMUST00000138812.1
mitochondrial ribosomal protein S17
chr10_-_80701811 0.02 ENSMUST00000003438.9
MOB kinase activator 3A
chr18_+_4994600 0.01 ENSMUST00000140448.1
supervillin
chr11_-_83020788 0.01 ENSMUST00000038141.8
ENSMUST00000092838.4
schlafen 8
chr3_-_83049797 0.01 ENSMUST00000048246.3
fibrinogen beta chain
chr4_-_110292719 0.01 ENSMUST00000106601.1
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr16_+_38362205 0.01 ENSMUST00000023494.6
popeye domain containing 2
chr5_-_136198908 0.00 ENSMUST00000149151.1
ENSMUST00000151786.1
Prkr interacting protein 1 (IL11 inducible)
chrX_-_145505175 0.00 ENSMUST00000143610.1
angiomotin
chr10_-_80813486 0.00 ENSMUST00000181039.1
ENSMUST00000180438.1
junctional sarcoplasmic reticulum protein 1
chr11_-_116626951 0.00 ENSMUST00000103028.1
rhomboid 5 homolog 2 (Drosophila)
chr9_+_44398176 0.00 ENSMUST00000165839.1
solute carrier family 37 (glucose-6-phosphate transporter), member 4

Network of associatons between targets according to the STRING database.

First level regulatory network of Mecom

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0060769 lateral sprouting involved in mammary gland duct morphogenesis(GO:0060599) tertiary branching involved in mammary gland duct morphogenesis(GO:0060748) positive regulation of epithelial cell proliferation involved in prostate gland development(GO:0060769)
0.1 0.9 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.1 0.3 GO:0046898 response to cycloheximide(GO:0046898)
0.1 0.3 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.1 0.4 GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291)
0.0 0.2 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
0.0 0.2 GO:0032224 positive regulation of synaptic transmission, cholinergic(GO:0032224)
0.0 0.3 GO:0035878 nail development(GO:0035878)
0.0 0.1 GO:0009253 peptidoglycan metabolic process(GO:0000270) natural killer cell differentiation involved in immune response(GO:0002325) peptidoglycan catabolic process(GO:0009253) negative regulation of natural killer cell differentiation(GO:0032824) regulation of natural killer cell differentiation involved in immune response(GO:0032826) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827)
0.0 0.2 GO:0097324 melanocyte migration(GO:0097324) positive regulation of lens fiber cell differentiation(GO:1902748)
0.0 0.1 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.0 0.2 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.0 0.2 GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.0 0.1 GO:1900039 positive regulation of cellular response to hypoxia(GO:1900039)
0.0 0.1 GO:0018002 N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
0.0 0.1 GO:0015074 DNA integration(GO:0015074)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0034687 integrin alphaL-beta2 complex(GO:0034687)
0.0 0.3 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.3 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.1 GO:0044305 calyx of Held(GO:0044305)
0.0 0.2 GO:0005916 fascia adherens(GO:0005916)
0.0 0.2 GO:0005605 basal lamina(GO:0005605)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0030369 ICAM-3 receptor activity(GO:0030369)
0.0 0.3 GO:0038132 neuregulin binding(GO:0038132)
0.0 0.1 GO:0004794 L-threonine ammonia-lyase activity(GO:0004794)
0.0 0.2 GO:0043532 angiostatin binding(GO:0043532)
0.0 0.1 GO:0008745 N-acetylmuramoyl-L-alanine amidase activity(GO:0008745) peptidoglycan receptor activity(GO:0016019)
0.0 0.3 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.2 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 0.9 GO:0070888 E-box binding(GO:0070888)
0.0 0.4 GO:0035250 UDP-galactosyltransferase activity(GO:0035250)
0.0 0.1 GO:1990190 peptide-glutamate-N-acetyltransferase activity(GO:1990190)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.4 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 0.3 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.4 NABA PROTEOGLYCANS Genes encoding proteoglycans

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME INFLAMMASOMES Genes involved in Inflammasomes