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12D miR HR13_24

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Results for Six3_Six1_Six2

Z-value: 0.47

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Transcription factors associated with Six3_Six1_Six2

Gene Symbol Gene ID Gene Info
ENSMUSG00000038805.9 sine oculis-related homeobox 3
ENSMUSG00000051367.8 sine oculis-related homeobox 1
ENSMUSG00000024134.10 sine oculis-related homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Six2mm10_v2_chr17_-_85688252_85688275-0.491.3e-01Click!
Six3mm10_v2_chr17_+_85613432_85613608-0.234.9e-01Click!
Six1mm10_v2_chr12_-_73047179_730471790.029.4e-01Click!

Activity profile of Six3_Six1_Six2 motif

Sorted Z-values of Six3_Six1_Six2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_65123108 0.89 ENSMUST00000050047.3
ENSMUST00000148020.1
RIKEN cDNA D630023F18 gene
chr15_-_82244716 0.55 ENSMUST00000089155.4
ENSMUST00000089157.3
centromere protein M
chr1_+_139454747 0.54 ENSMUST00000053364.8
ENSMUST00000097554.3
asp (abnormal spindle)-like, microcephaly associated (Drosophila)
chr2_+_31245801 0.47 ENSMUST00000000199.7
neuronal calcium sensor 1
chr3_+_94398517 0.40 ENSMUST00000050975.3
leucine rich repeat and Ig domain containing 4
chr19_-_44135816 0.37 ENSMUST00000026218.5
CWF19-like 1, cell cycle control (S. pombe)
chr9_+_106222598 0.34 ENSMUST00000062241.9
toll-like receptor 9
chr7_-_126676357 0.30 ENSMUST00000106371.1
ENSMUST00000106372.3
ENSMUST00000155419.1
sulfotransferase family 1A, phenol-preferring, member 1
chr13_+_94083490 0.28 ENSMUST00000156071.1
lipoma HMGIC fusion partner-like 2
chr18_+_62180119 0.28 ENSMUST00000067743.1
predicted gene 9949
chr15_+_98571004 0.27 ENSMUST00000023728.6
RIKEN cDNA 4930415O20 gene
chr7_+_131032061 0.22 ENSMUST00000084509.3
deleted in malignant brain tumors 1
chrX_+_169685191 0.21 ENSMUST00000112104.1
ENSMUST00000112107.1
midline 1
chr16_-_45724600 0.20 ENSMUST00000096057.4
transgelin 3
chrX_-_142966709 0.20 ENSMUST00000041317.2
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr3_-_37724321 0.19 ENSMUST00000108105.1
ENSMUST00000079755.4
ENSMUST00000099128.1
predicted gene 5148
chr2_+_127336152 0.18 ENSMUST00000028846.6
dual specificity phosphatase 2
chr14_+_57798182 0.18 ENSMUST00000111269.1
Sin3-associated polypeptide 18
chr8_-_4275886 0.17 ENSMUST00000003029.7
translocase of inner mitochondrial membrane 44
chr10_+_23949516 0.17 ENSMUST00000045152.4
trace amine-associated receptor 3
chrX_-_74373218 0.15 ENSMUST00000178691.1
ENSMUST00000114146.1
ubiquitin-like 4
solute carrier family 10 (sodium/bile acid cotransporter family), member 3
chr19_-_23075853 0.14 ENSMUST00000181623.1
RIKEN cDNA C330002G04 gene
chr7_-_119459266 0.14 ENSMUST00000033255.5
glycoprotein 2 (zymogen granule membrane)
chr15_+_82252397 0.12 ENSMUST00000136948.1
RIKEN cDNA 1500009C09 gene
chr5_+_139423151 0.11 ENSMUST00000066211.4
G protein-coupled estrogen receptor 1
chr1_+_136467958 0.10 ENSMUST00000047817.6
kinesin family member 14
chrX_-_74373260 0.10 ENSMUST00000073067.4
ENSMUST00000037967.5
solute carrier family 10 (sodium/bile acid cotransporter family), member 3
chr13_+_104229366 0.10 ENSMUST00000022227.6
centromere protein K
chr16_+_22920222 0.09 ENSMUST00000023587.4
ENSMUST00000116625.2
fetuin beta
chr9_+_98422961 0.09 ENSMUST00000052068.9
retinol binding protein 1, cellular
chr7_-_126676428 0.08 ENSMUST00000106373.1
sulfotransferase family 1A, phenol-preferring, member 1
chr7_-_80115294 0.08 ENSMUST00000107384.3
isocitrate dehydrogenase 2 (NADP+), mitochondrial
chr8_+_69832633 0.08 ENSMUST00000131637.2
ENSMUST00000081503.6
pre B cell leukemia homeobox 4
chr10_+_24595623 0.07 ENSMUST00000176228.1
ENSMUST00000129142.1
connective tissue growth factor
chr6_+_48537560 0.07 ENSMUST00000040361.5
ATPase, H+ transporting, lysosomal V0 subunit E2
chr17_-_40914350 0.07 ENSMUST00000166343.1
glycine-N-acyltransferase-like 3
chr4_-_43030440 0.06 ENSMUST00000135660.1
stomatin (Epb7.2)-like 2
chr4_-_32950813 0.06 ENSMUST00000084750.1
ENSMUST00000084748.2
ankyrin repeat domain 6
chr14_+_57798156 0.06 ENSMUST00000128764.1
Sin3-associated polypeptide 18
chr16_-_11203259 0.05 ENSMUST00000119953.1
ribosomal L1 domain containing 1
chr17_+_35241746 0.05 ENSMUST00000068056.5
ENSMUST00000174757.1
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr2_-_13271268 0.05 ENSMUST00000137670.1
ENSMUST00000114791.2
Ras suppressor protein 1
chr4_-_60582152 0.05 ENSMUST00000098047.2
major urinary protein 10
chr15_-_76206309 0.04 ENSMUST00000073418.6
ENSMUST00000171634.1
ENSMUST00000076442.5
plectin
chr11_-_101987004 0.04 ENSMUST00000107173.2
ENSMUST00000107172.1
dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)
chr7_-_101903783 0.04 ENSMUST00000106969.1
transmembrane O-methyltransferase
chr19_-_55315980 0.04 ENSMUST00000076891.5
zinc finger, DHHC domain containing 6
chr6_+_123123423 0.04 ENSMUST00000032248.7
C-type lectin domain family 4, member a2
chr13_+_43785107 0.04 ENSMUST00000015540.2
CD83 antigen
chr6_+_38534823 0.04 ENSMUST00000019833.4
RIKEN cDNA 1110001J03 gene
chr17_+_35241838 0.04 ENSMUST00000173731.1
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr8_-_86885222 0.03 ENSMUST00000034074.7
NEDD4 binding protein 1
chr9_-_70503718 0.03 ENSMUST00000034739.5
ring finger 111
chr3_-_40509737 0.03 ENSMUST00000179966.1
RIKEN cDNA 1700017G19 gene
chr4_-_60421933 0.03 ENSMUST00000107506.2
ENSMUST00000122381.1
ENSMUST00000118759.1
ENSMUST00000122177.1
major urinary protein 9
chr2_-_13271419 0.03 ENSMUST00000028059.2
Ras suppressor protein 1
chr5_+_104046869 0.02 ENSMUST00000031250.7
nudix (nucleoside diphosphate linked moiety X)-type motif 9
chr8_+_84831522 0.02 ENSMUST00000036734.5
growth arrest and DNA-damage-inducible, gamma interacting protein 1
chr16_-_18235074 0.02 ENSMUST00000076957.5
zinc finger, DHHC domain containing 8
chr15_+_38661904 0.02 ENSMUST00000022904.6
ATPase, H+ transporting, lysosomal V1 subunit C1
chr8_-_22653406 0.02 ENSMUST00000033938.5
polymerase (DNA directed), beta
chr9_-_121839460 0.02 ENSMUST00000135986.2
coiled-coil domain containing 13
chr19_-_38043559 0.02 ENSMUST00000041475.8
ENSMUST00000172095.2
myoferlin
chr2_+_117249725 0.02 ENSMUST00000028825.4
family with sequence similarity 98, member B
chr4_-_106730925 0.01 ENSMUST00000148281.1
maestro heat-like repeat family member 7
chr5_+_138820080 0.01 ENSMUST00000179205.1
predicted gene 5294
chr17_+_40811089 0.01 ENSMUST00000024721.7
Rhesus blood group-associated A glycoprotein
chr11_-_99230998 0.01 ENSMUST00000103133.3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
chr10_+_70868633 0.01 ENSMUST00000058942.5
RIKEN cDNA 4930533K18 gene
chr16_+_11203375 0.01 ENSMUST00000181526.1
RIKEN cDNA 2610020C07 gene
chr6_-_115675871 0.01 ENSMUST00000112949.1
v-raf-leukemia viral oncogene 1
chr4_-_116651644 0.01 ENSMUST00000030455.8
aldo-keto reductase family 1, member A1 (aldehyde reductase)
chr7_+_30232310 0.01 ENSMUST00000108193.1
ENSMUST00000108192.1
polymerase (RNA) II (DNA directed) polypeptide I
chr12_+_84773262 0.00 ENSMUST00000021667.5
iron-sulfur cluster assembly 2 homolog (S. cerevisiae)
chr14_+_55765956 0.00 ENSMUST00000057569.3
leukotriene B4 receptor 1
chr5_+_140607334 0.00 ENSMUST00000031555.1
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

Network of associatons between targets according to the STRING database.

First level regulatory network of Six3_Six1_Six2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0034165 positive regulation of interleukin-18 production(GO:0032741) positive regulation of toll-like receptor 9 signaling pathway(GO:0034165)
0.1 0.5 GO:0051661 maintenance of centrosome location(GO:0051661)
0.1 0.1 GO:1990773 regulation of matrix metallopeptidase secretion(GO:1904464) matrix metallopeptidase secretion(GO:1990773)
0.0 0.1 GO:0051385 positive regulation of inositol trisphosphate biosynthetic process(GO:0032962) response to mineralocorticoid(GO:0051385) regulation of cardiac vascular smooth muscle cell differentiation(GO:2000722) positive regulation of cardiac vascular smooth muscle cell differentiation(GO:2000724)
0.0 0.1 GO:0033624 negative regulation of integrin activation(GO:0033624)
0.0 0.1 GO:0033189 response to vitamin A(GO:0033189)
0.0 0.1 GO:0002386 immune response in mucosal-associated lymphoid tissue(GO:0002386)
0.0 0.4 GO:0051923 sulfation(GO:0051923)
0.0 0.1 GO:1900210 positive regulation of mitochondrial DNA replication(GO:0090297) regulation of cardiolipin metabolic process(GO:1900208) positive regulation of cardiolipin metabolic process(GO:1900210) stress-induced mitochondrial fusion(GO:1990046)
0.0 0.2 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.1 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.0 0.1 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.0 0.2 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.0 0.2 GO:0030150 protein import into mitochondrial matrix(GO:0030150)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0036019 endolysosome(GO:0036019)
0.1 0.5 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.2 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 0.2 GO:0061574 ASAP complex(GO:0061574)
0.0 0.5 GO:0031045 dense core granule(GO:0031045)
0.0 0.1 GO:0032591 dendritic spine membrane(GO:0032591)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0 0.3 GO:0045322 unmethylated CpG binding(GO:0045322)
0.0 0.2 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.1 GO:0017082 mineralocorticoid receptor activity(GO:0017082)
0.0 0.1 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.0 0.2 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 0.1 GO:0030621 U4 snRNA binding(GO:0030621)
0.0 0.0 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.0 0.2 GO:0033549 MAP kinase phosphatase activity(GO:0033549)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.3 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling