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12D miR HR13_24

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Results for Aire

Z-value: 0.68

Motif logo

Transcription factors associated with Aire

Gene Symbol Gene ID Gene Info
ENSMUSG00000000731.9 autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)

Activity profile of Aire motif

Sorted Z-values of Aire motif

Promoter Log-likelihood Transcript Gene Gene Info
chrX_-_61185558 3.15 ENSMUST00000166381.1
cerebellar degeneration related antigen 1
chr14_-_47418407 1.30 ENSMUST00000043296.3
discs, large (Drosophila) homolog-associated protein 5
chr8_+_69808672 1.16 ENSMUST00000036074.8
ENSMUST00000123453.1
Gem-interacting protein
chr5_-_135251209 1.04 ENSMUST00000062572.2
frizzled homolog 9 (Drosophila)
chr12_-_36156781 0.91 ENSMUST00000020856.4
basic leucine zipper and W2 domains 2
chr4_+_11758147 0.91 ENSMUST00000029871.5
ENSMUST00000108303.1
cadherin 17
chr10_-_81014902 0.64 ENSMUST00000126317.1
ENSMUST00000092285.3
ENSMUST00000117805.1
guanine nucleotide binding protein (G protein), gamma 7
chr6_+_40964760 0.64 ENSMUST00000076638.5
RIKEN cDNA 1810009J06 gene
chr8_-_4217261 0.62 ENSMUST00000168386.2
cDNA sequence BC068157
chr17_-_35516780 0.62 ENSMUST00000160885.1
ENSMUST00000159009.1
ENSMUST00000161012.1
transcription factor 19
chr6_-_40999479 0.61 ENSMUST00000166306.1
predicted gene 2663
chr9_+_64235201 0.59 ENSMUST00000039011.3
ubiquitin carboxyl-terminal esterase L4
chr3_-_88410295 0.59 ENSMUST00000056370.7
polyamine-modulated factor 1
chr8_-_4216912 0.56 ENSMUST00000177491.1
cDNA sequence BC068157
chr8_-_4217133 0.54 ENSMUST00000175906.1
cDNA sequence BC068157
chr13_-_110280103 0.51 ENSMUST00000167824.1
RAB3C, member RAS oncogene family
chrM_+_7005 0.49 ENSMUST00000082405.1
mitochondrially encoded cytochrome c oxidase II
chr13_+_55445301 0.47 ENSMUST00000001115.8
ENSMUST00000099482.3
G protein-coupled receptor kinase 6
chr14_-_70524068 0.45 ENSMUST00000022692.3
surfactant associated protein C
chr3_+_94443315 0.45 ENSMUST00000029786.7
ENSMUST00000098876.3
mitochondrial ribosomal protein L9
chr3_-_33082004 0.45 ENSMUST00000108225.3
peroxisomal biogenesis factor 5-like
chr2_+_175283298 0.43 ENSMUST00000098998.3
predicted gene 14440
chr19_-_28963863 0.43 ENSMUST00000161813.1
RIKEN cDNA 4430402I18 gene
chr19_+_39287074 0.42 ENSMUST00000003137.8
cytochrome P450, family 2, subfamily c, polypeptide 29
chr2_+_55435918 0.42 ENSMUST00000067101.3
potassium inwardly-rectifying channel, subfamily J, member 3
chr7_-_141434532 0.40 ENSMUST00000133021.1
ENSMUST00000106007.3
ENSMUST00000150026.1
ENSMUST00000133206.2
solute carrier family 25 (mitochondrial carrier, glutamate), member 22
chr4_+_154869585 0.40 ENSMUST00000079269.7
ENSMUST00000163732.1
ENSMUST00000080559.6
membrane metallo-endopeptidase-like 1
chr14_-_18894255 0.38 ENSMUST00000124353.1
ubiquitin-conjugating enzyme E2E 2
chrM_+_8600 0.38 ENSMUST00000082409.1
mitochondrially encoded cytochrome c oxidase III
chr11_+_120608469 0.38 ENSMUST00000106194.1
ENSMUST00000106195.2
neuropeptide B
chr14_-_57571551 0.36 ENSMUST00000022518.5
N-6 adenine-specific DNA methyltransferase 2 (putative)
chr2_+_176431829 0.36 ENSMUST00000172025.1
predicted gene 14435
chrM_+_7759 0.34 ENSMUST00000082407.1
ENSMUST00000082408.1
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chrM_+_14138 0.29 ENSMUST00000082421.1
mitochondrially encoded cytochrome b
chr7_-_14562171 0.29 ENSMUST00000181796.1
vomeronasal 1 receptor 90
chr19_-_4191035 0.28 ENSMUST00000045864.2
TBC1 domain family, member 10c
chr9_-_53610329 0.27 ENSMUST00000034547.5
acetyl-Coenzyme A acetyltransferase 1
chr10_-_111997204 0.26 ENSMUST00000074805.5
GLI pathogenesis-related 1 (glioma)
chr1_-_128359610 0.26 ENSMUST00000027601.4
minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)
chr19_-_5663701 0.24 ENSMUST00000071857.5
ENSMUST00000080824.5
ENSMUST00000164304.1
ENSMUST00000169854.1
signal-induced proliferation associated gene 1
chr10_+_79960145 0.24 ENSMUST00000045247.7
WD repeat domain 18
chr1_+_189728264 0.24 ENSMUST00000097442.2
protein tyrosine phosphatase, non-receptor type 14
chr5_-_84417359 0.23 ENSMUST00000113401.1
Eph receptor A5
chr17_-_6961156 0.23 ENSMUST00000063683.6
T cell activation GTPase activating protein 1
chr9_-_106096776 0.22 ENSMUST00000121963.1
collagen, type VI, alpha 4
chr6_+_40628824 0.22 ENSMUST00000071535.6
maltase-glucoamylase
chr11_+_70166623 0.21 ENSMUST00000102571.3
ENSMUST00000178945.1
ENSMUST00000000327.6
C-type lectin domain family 10, member A
chrX_-_38576166 0.20 ENSMUST00000050083.5
cullin 4B
chrM_-_14060 0.20 ENSMUST00000082419.1
mitochondrially encoded NADH dehydrogenase 6
chr6_-_148896150 0.20 ENSMUST00000072324.5
ENSMUST00000111569.2
caprin family member 2
chr10_+_37139558 0.19 ENSMUST00000062667.3
RIKEN cDNA 5930403N24 gene
chr1_+_44119952 0.19 ENSMUST00000114709.2
basic, immunoglobulin-like variable motif containing
chr19_-_6118491 0.19 ENSMUST00000113533.1
SAC3 domain containing 1
chr3_+_79568192 0.18 ENSMUST00000091023.1
RIKEN cDNA 4930589L23 gene
chr2_-_94010729 0.18 ENSMUST00000040005.6
ENSMUST00000126378.1
alkB, alkylation repair homolog 3 (E. coli)
chr11_+_3963970 0.18 ENSMUST00000020705.4
ENSMUST00000109985.1
pescadillo homolog 1, containing BRCT domain (zebrafish)
chrX_-_38576189 0.18 ENSMUST00000115118.1
cullin 4B
chr11_-_115627948 0.18 ENSMUST00000154623.1
ENSMUST00000106503.3
ENSMUST00000141614.1
solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19
chr2_-_165400398 0.17 ENSMUST00000029213.4
osteoclast stimulatory transmembrane protein
chr3_+_88835231 0.17 ENSMUST00000107498.2
gon-4-like (C.elegans)
chr3_+_89459118 0.17 ENSMUST00000029564.5
phosphomevalonate kinase
chr5_+_43672289 0.16 ENSMUST00000156034.1
coiled-coil and C2 domain containing 2A
chr8_+_111643425 0.16 ENSMUST00000077791.6
zinc finger protein 1
chr10_-_130280218 0.16 ENSMUST00000061571.3
neurogenic differentiation 4
chr9_-_53667429 0.16 ENSMUST00000166367.1
ENSMUST00000034529.7
cullin 5
chr13_+_49504774 0.15 ENSMUST00000051504.7
extracellular matrix protein 2, female organ and adipocyte specific
chrX_+_74127463 0.15 ENSMUST00000033771.4
ENSMUST00000101457.3
opsin 1 (cone pigments), medium-wave-sensitive (color blindness, deutan)
chr17_-_42692244 0.15 ENSMUST00000170723.1
ENSMUST00000164524.1
ENSMUST00000024711.4
ENSMUST00000167993.1
G protein-coupled receptor 115
chr15_+_101266839 0.14 ENSMUST00000023779.6
nuclear receptor subfamily 4, group A, member 1
chr5_+_24100578 0.14 ENSMUST00000030841.5
ENSMUST00000163409.1
kelch-like 7
chr2_-_94010807 0.14 ENSMUST00000111240.1
alkB, alkylation repair homolog 3 (E. coli)
chr10_+_57650977 0.13 ENSMUST00000066028.6
protein kinase inhibitor beta, cAMP dependent, testis specific
chrM_+_11734 0.13 ENSMUST00000082418.1
mitochondrially encoded NADH dehydrogenase 5
chr5_+_140735526 0.13 ENSMUST00000120630.2
archaelysin family metallopeptidase 1
chr5_+_130369420 0.12 ENSMUST00000086029.3
calneuron 1
chr11_+_120608492 0.12 ENSMUST00000061309.4
neuropeptide B
chr2_+_25218741 0.12 ENSMUST00000028346.3
family with sequence similarity 166, member A
chrX_+_101429555 0.12 ENSMUST00000033673.6
non-POU-domain-containing, octamer binding protein
chr14_+_21481428 0.12 ENSMUST00000182996.1
K(lysine) acetyltransferase 6B
chr5_-_113310697 0.11 ENSMUST00000154248.1
small G protein signaling modulator 1
chr5_-_50058908 0.10 ENSMUST00000030971.5
G protein-coupled receptor 125
chr17_-_53463315 0.10 ENSMUST00000024725.4
EF hand domain family, member B
chr11_+_67052641 0.10 ENSMUST00000108690.3
ENSMUST00000092996.4
SCO cytochrome oxidase deficient homolog 1 (yeast)
chr3_+_57425314 0.09 ENSMUST00000029377.7
transmembrane 4 superfamily member 4
chr6_+_56956466 0.08 ENSMUST00000096612.3
vomeronasal 1 receptor 4
chr2_+_128591205 0.08 ENSMUST00000155430.1
predicted gene 355
chr16_+_23058250 0.08 ENSMUST00000039492.6
ENSMUST00000023589.8
ENSMUST00000089902.6
kininogen 1
chr17_-_73950172 0.07 ENSMUST00000024866.4
xanthine dehydrogenase
chr16_-_8425104 0.07 ENSMUST00000023400.2
claudin 26
chr19_+_11895999 0.06 ENSMUST00000072784.2
olfactory receptor 1420
chr4_-_46566432 0.06 ENSMUST00000030021.7
ENSMUST00000107757.1
coronin, actin binding protein 2A
chr8_+_88289028 0.06 ENSMUST00000171456.1
adenylate cyclase 7
chr19_+_34217588 0.05 ENSMUST00000119603.1
STAM binding protein like 1
chr10_+_3872667 0.05 ENSMUST00000136671.1
ENSMUST00000042438.6
pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr18_+_36793918 0.04 ENSMUST00000001419.8
zinc finger, matrin type 2
chr14_-_63037833 0.04 ENSMUST00000111207.1
ENSMUST00000100490.2
defensin beta 30
chr7_-_127895578 0.04 ENSMUST00000033074.6
vitamin K epoxide reductase complex, subunit 1
chr7_-_115846080 0.04 ENSMUST00000166207.1
SRY-box containing gene 6
chr16_-_91618986 0.03 ENSMUST00000143058.1
ENSMUST00000049244.8
ENSMUST00000169982.1
ENSMUST00000133731.1
DnaJ (Hsp40) homolog, subfamily C, member 28
chrX_+_48256854 0.03 ENSMUST00000080713.4
UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
chr12_+_4843303 0.03 ENSMUST00000053034.4
cDNA sequence BC068281
chr10_+_53337686 0.03 ENSMUST00000046221.6
ENSMUST00000163319.1
phospholamban
chr5_+_137981512 0.02 ENSMUST00000035390.5
alpha-2-glycoprotein 1, zinc
chr5_+_30921867 0.02 ENSMUST00000123885.1
ketohexokinase
chr5_-_105051047 0.02 ENSMUST00000112718.4
guanylate-binding protein 8
chr7_+_45897429 0.02 ENSMUST00000140243.1
transmembrane protein 143
chr2_-_112259281 0.01 ENSMUST00000043970.1
NUT midline carcinoma, family member 1
chr15_+_22549022 0.01 ENSMUST00000163361.1
cadherin 18
chr10_+_57650990 0.01 ENSMUST00000175852.1
protein kinase inhibitor beta, cAMP dependent, testis specific
chr19_-_58793277 0.01 ENSMUST00000166692.1
RIKEN cDNA 1700019N19 gene

Network of associatons between targets according to the STRING database.

First level regulatory network of Aire

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:1990523 bone regeneration(GO:1990523)
0.3 0.9 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.1 0.5 GO:0010360 negative regulation of anion channel activity(GO:0010360)
0.1 0.3 GO:0006550 isoleucine catabolic process(GO:0006550)
0.1 0.3 GO:0035552 oxidative single-stranded DNA demethylation(GO:0035552) oxidative single-stranded RNA demethylation(GO:0035553)
0.1 0.6 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1 0.2 GO:0009414 response to water deprivation(GO:0009414)
0.1 0.4 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.1 0.5 GO:0016560 protein import into peroxisome matrix, docking(GO:0016560)
0.0 0.3 GO:0033762 response to glucagon(GO:0033762)
0.0 0.4 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.2 GO:0030974 thiamine pyrophosphate transport(GO:0030974)
0.0 0.2 GO:0034241 positive regulation of macrophage fusion(GO:0034241)
0.0 0.2 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.0 0.3 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.0 0.2 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.0 0.4 GO:0070914 UV-damage excision repair(GO:0070914)
0.0 0.4 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.0 0.3 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 0.8 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.0 0.1 GO:0002248 connective tissue replacement involved in inflammatory response wound healing(GO:0002248)
0.0 0.2 GO:0007000 nucleolus organization(GO:0007000)
0.0 0.2 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.0 0.1 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.0 0.1 GO:0046110 xanthine catabolic process(GO:0009115) xanthine metabolic process(GO:0046110)
0.0 0.2 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.4 GO:0015813 L-glutamate transport(GO:0015813)
0.0 0.0 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.0 0.2 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
0.0 1.0 GO:0022904 respiratory electron transport chain(GO:0022904)
0.0 0.3 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.1 0.5 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.1 1.3 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 1.3 GO:0031527 filopodium membrane(GO:0031527)
0.1 0.4 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0 0.5 GO:0097208 alveolar lamellar body(GO:0097208)
0.0 0.5 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.3 GO:0045275 respiratory chain complex III(GO:0045275)
0.0 0.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.2 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 0.2 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.3 GO:0042555 MCM complex(GO:0042555)
0.0 0.1 GO:0042382 paraspeckles(GO:0042382)
0.0 0.1 GO:0033648 host intracellular organelle(GO:0033647) host intracellular membrane-bounded organelle(GO:0033648)
0.0 0.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.2 GO:0036038 MKS complex(GO:0036038)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.1 0.4 GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.1 0.5 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.1 0.3 GO:0051747 cytosine C-5 DNA demethylase activity(GO:0051747)
0.1 0.5 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.1 0.4 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 0.4 GO:0042296 ISG15 transferase activity(GO:0042296)
0.1 0.2 GO:0070052 collagen V binding(GO:0070052)
0.0 0.3 GO:0003985 acetyl-CoA C-acetyltransferase activity(GO:0003985) C-acetyltransferase activity(GO:0016453)
0.0 1.0 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.2 GO:0032450 maltose alpha-glucosidase activity(GO:0032450)
0.0 0.6 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.3 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.9 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.4 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 0.2 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.0 0.2 GO:0015234 thiamine transmembrane transporter activity(GO:0015234)
0.0 0.5 GO:0031489 myosin V binding(GO:0031489)
0.0 0.2 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.1 GO:0004854 xanthine dehydrogenase activity(GO:0004854) oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor(GO:0016726)
0.0 0.1 GO:0005550 pheromone binding(GO:0005550)
0.0 0.3 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 1.3 PID AURORA A PATHWAY Aurora A signaling
0.0 0.4 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 1.1 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.2 REACTOME OPSINS Genes involved in Opsins
0.0 0.3 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 1.0 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.3 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism