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12D miR HR13_24

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Results for Pax6

Z-value: 0.78

Motif logo

Transcription factors associated with Pax6

Gene Symbol Gene ID Gene Info
ENSMUSG00000027168.15 paired box 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Pax6mm10_v2_chr2_+_105682463_105682547-0.672.3e-02Click!

Activity profile of Pax6 motif

Sorted Z-values of Pax6 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_101869012 1.86 ENSMUST00000123321.1
folate receptor 1 (adult)
chr7_-_101868667 1.63 ENSMUST00000150184.1
folate receptor 1 (adult)
chr11_+_61022560 1.54 ENSMUST00000089184.4
potassium inwardly-rectifying channel, subfamily J, member 12
chr18_-_32139570 1.17 ENSMUST00000171765.1
protein C
chr8_-_24948771 1.07 ENSMUST00000119720.1
ENSMUST00000121438.2
a disintegrin and metallopeptidase domain 32
chr9_+_92250039 0.98 ENSMUST00000093801.3
phospholipid scramblase 1
chrX_+_73214333 0.94 ENSMUST00000156188.1
ENSMUST00000069077.3
ENSMUST00000069103.4
ENSMUST00000114506.1
ENSMUST00000081827.3
X-linked lymphocyte-regulated 4B
chr1_+_43092588 0.90 ENSMUST00000039080.3
RIKEN cDNA 8430432A02 gene
chrX_+_103422010 0.81 ENSMUST00000182089.1
predicted gene, 26992
chr13_-_23914998 0.75 ENSMUST00000021769.8
ENSMUST00000110407.2
solute carrier family 17 (sodium phosphate), member 4
chr19_-_57118981 0.73 ENSMUST00000111528.1
ENSMUST00000111529.1
ENSMUST00000104902.2
actin-binding LIM protein 1
chr15_-_101850778 0.72 ENSMUST00000023790.3
keratin 1
chr17_+_43016536 0.72 ENSMUST00000024708.4
tumor necrosis factor receptor superfamily, member 21
chr5_+_90903864 0.61 ENSMUST00000075433.6
chemokine (C-X-C motif) ligand 2
chr4_-_34050077 0.58 ENSMUST00000029927.5
sperm acrosome associated 1
chr3_+_31902507 0.58 ENSMUST00000119310.1
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr18_+_37447641 0.56 ENSMUST00000052387.3
protocadherin beta 14
chr16_-_52452654 0.51 ENSMUST00000168071.1
activated leukocyte cell adhesion molecule
chr13_+_64432479 0.51 ENSMUST00000021939.6
cyclin-dependent kinase 20
chrX_+_23693043 0.46 ENSMUST00000035766.6
ENSMUST00000101670.2
WD repeat domain 44
chr4_-_71757965 0.44 ENSMUST00000084489.2
predicted gene 11232
chr17_-_51832666 0.42 ENSMUST00000144331.1
special AT-rich sequence binding protein 1
chr13_-_62607499 0.42 ENSMUST00000091563.4
RIKEN cDNA 6720489N17 gene
chr19_-_57118897 0.41 ENSMUST00000111526.1
actin-binding LIM protein 1
chr5_+_149265035 0.39 ENSMUST00000130144.1
ENSMUST00000071130.3
arachidonate 5-lipoxygenase activating protein
chr5_-_74677792 0.39 ENSMUST00000117525.1
ENSMUST00000153543.1
ENSMUST00000039744.6
ENSMUST00000113531.2
ENSMUST00000121690.1
ligand of numb-protein X 1
chr9_+_15239045 0.39 ENSMUST00000034413.6
V-set and transmembrane domain containing 5
chr2_-_162661075 0.37 ENSMUST00000109442.1
ENSMUST00000109445.2
ENSMUST00000109443.1
ENSMUST00000109441.1
protein tyrosine phosphatase, receptor type, T
chr6_+_48395586 0.33 ENSMUST00000114571.1
ENSMUST00000114572.3
ENSMUST00000031815.5
KRAB-A domain containing 1
chr1_+_156040884 0.32 ENSMUST00000060404.4
torsin A interacting protein 2
chr2_+_163602331 0.32 ENSMUST00000152135.1
tocopherol (alpha) transfer protein-like
chr2_+_163602294 0.32 ENSMUST00000171696.1
ENSMUST00000109408.3
tocopherol (alpha) transfer protein-like
chr10_-_53694823 0.31 ENSMUST00000171807.1
family with sequence similarity 184, member A
chr18_-_34373313 0.29 ENSMUST00000006027.5
receptor accessory protein 5
chr9_-_22307638 0.28 ENSMUST00000086278.6
zinc finger protein 810
chr7_+_97453204 0.28 ENSMUST00000050732.7
ENSMUST00000121987.1
potassium channel tetramerisation domain containing 14
chr13_-_53377355 0.28 ENSMUST00000021920.6
serine palmitoyltransferase, long chain base subunit 1
chr9_+_64179289 0.27 ENSMUST00000034965.6
small nuclear RNA activating complex, polypeptide 5
chr3_-_98753465 0.27 ENSMUST00000094050.4
ENSMUST00000090743.6
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3
chr2_-_75981967 0.27 ENSMUST00000099994.3
tetratricopeptide repeat domain 30A1
chr1_+_131638306 0.26 ENSMUST00000073350.6
cathepsin E
chr16_-_22857514 0.26 ENSMUST00000004576.6
TBCC domain containing 1
chr8_-_57962564 0.26 ENSMUST00000098757.3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6
chr2_+_105904629 0.25 ENSMUST00000037499.5
IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr8_+_45069137 0.24 ENSMUST00000067984.7
melatonin receptor 1A
chr6_+_48395652 0.23 ENSMUST00000077093.4
KRAB-A domain containing 1
chr13_-_43480973 0.21 ENSMUST00000144326.2
RAN binding protein 9
chr7_+_123462274 0.21 ENSMUST00000033023.3
aquaporin 8
chr7_+_64153916 0.20 ENSMUST00000107527.2
transient receptor potential cation channel, subfamily M, member 1
chr8_-_27228494 0.19 ENSMUST00000117565.1
adrenergic receptor, beta 3
chr12_+_112976471 0.18 ENSMUST00000165079.1
ENSMUST00000002880.6
BTB (POZ) domain containing 6
chr15_+_103272893 0.18 ENSMUST00000100162.3
coatomer protein complex, subunit zeta 1
chr1_+_21240597 0.18 ENSMUST00000121676.1
glutathione S-transferase, alpha 3
chr1_-_138619687 0.17 ENSMUST00000027642.2
NIMA (never in mitosis gene a)-related expressed kinase 7
chr19_+_6400611 0.17 ENSMUST00000113467.1
RAS, guanyl releasing protein 2
chr13_-_66905322 0.16 ENSMUST00000021993.4
ubiquinol-cytochrome c reductase binding protein
chr13_+_66905415 0.16 ENSMUST00000099412.2
predicted gene 10767
chr8_+_54600774 0.16 ENSMUST00000033917.6
spermatogenesis associated 4
chr11_+_45852031 0.16 ENSMUST00000109261.3
ENSMUST00000109260.1
clathrin interactor 1
chr12_-_51829525 0.15 ENSMUST00000179265.1
ENSMUST00000042052.8
HECT domain containing 1
chr7_+_75610038 0.15 ENSMUST00000125771.1
A kinase (PRKA) anchor protein 13
chr6_-_122856151 0.14 ENSMUST00000042081.8
complement component 3a receptor 1
chr17_-_17624458 0.14 ENSMUST00000041047.2
leucyl/cystinyl aminopeptidase
chr11_-_6200411 0.14 ENSMUST00000066496.3
NudC domain containing 3
chr3_+_65109343 0.14 ENSMUST00000159525.1
ENSMUST00000049230.8
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr11_-_115612491 0.14 ENSMUST00000106507.2
MIF4G domain containing
chr7_+_51511005 0.14 ENSMUST00000043944.5
anoctamin 5
chr17_-_43543639 0.12 ENSMUST00000178772.1
ankyrin repeat domain 66
chr13_-_24937585 0.12 ENSMUST00000037615.6
aldhehyde dehydrogenase family 5, subfamily A1
chr6_-_113377376 0.12 ENSMUST00000043333.2
transcriptional adaptor 3
chr3_-_36613285 0.11 ENSMUST00000108155.1
Bardet-Biedl syndrome 7 (human)
chr17_+_34604262 0.10 ENSMUST00000174041.1
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
chr7_+_12897800 0.10 ENSMUST00000055528.4
ENSMUST00000117189.1
ENSMUST00000120809.1
ENSMUST00000119989.1
zinc finger and SCAN domain containing 22
chr1_-_195131536 0.09 ENSMUST00000075451.6
complement component (3b/4b) receptor 1-like
chr17_-_51831884 0.09 ENSMUST00000124222.1
special AT-rich sequence binding protein 1
chr7_+_64153835 0.09 ENSMUST00000085222.5
ENSMUST00000107525.1
transient receptor potential cation channel, subfamily M, member 1
chr8_-_72475212 0.08 ENSMUST00000079510.4
calcium homeostasis endoplasmic reticulum protein
chr5_-_18360384 0.08 ENSMUST00000074694.5
guanine nucleotide binding protein (G protein), alpha inhibiting 1
chr17_+_25366550 0.08 ENSMUST00000069616.7
tryptase beta 2
chr5_-_38480131 0.07 ENSMUST00000143758.1
ENSMUST00000067886.5
solute carrier family 2 (facilitated glucose transporter), member 9
chr8_-_80880479 0.07 ENSMUST00000034150.8
growth factor receptor bound protein 2-associated protein 1
chr14_-_57890242 0.06 ENSMUST00000089473.3
zinc finger, DHHC domain containing 20
chr11_-_67965631 0.05 ENSMUST00000021287.5
ENSMUST00000126766.1
WD repeat domain 16
chr8_+_109614417 0.04 ENSMUST00000109242.1
ENSMUST00000057344.2
polycystic kidney disease 1 like 3
chr6_+_56956466 0.03 ENSMUST00000096612.3
vomeronasal 1 receptor 4
chr4_-_59915035 0.03 ENSMUST00000030081.1
solute carrier family 46, member 2
chr6_-_88045190 0.03 ENSMUST00000113596.1
ENSMUST00000113600.3
RAB7, member RAS oncogene family
chr1_-_120120138 0.03 ENSMUST00000112648.1
ENSMUST00000128408.1
diazepam binding inhibitor
chr7_+_26061495 0.02 ENSMUST00000005669.7
cytochrome P450, family 2, subfamily b, polypeptide 13
chr1_+_156040909 0.02 ENSMUST00000065648.8
ENSMUST00000097526.2
torsin A interacting protein 2
chr11_-_84870646 0.01 ENSMUST00000018547.2
gametogenetin binding protein 2
chr14_-_43819639 0.01 ENSMUST00000100691.3
eosinophil-associated, ribonuclease A family, member 1
chr7_-_26686437 0.01 ENSMUST00000077356.6
cytochrome P450, family 2, subfamily b, polypeptide 23
chr1_+_21240581 0.01 ENSMUST00000027067.8
glutathione S-transferase, alpha 3
chr4_+_129820702 0.00 ENSMUST00000165853.1
protein tyrosine phosphatase 4a2
chr9_+_105642957 0.00 ENSMUST00000065778.6
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 4, p150
chr7_+_30422389 0.00 ENSMUST00000108175.1
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, delta

Network of associatons between targets according to the STRING database.

First level regulatory network of Pax6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.5 GO:0071231 neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713) cellular response to folic acid(GO:0071231)
0.3 1.0 GO:0070782 phosphatidylserine exposure on apoptotic cell surface(GO:0070782) regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
0.2 0.7 GO:0032696 negative regulation of interleukin-13 production(GO:0032696)
0.2 1.2 GO:1903142 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.1 0.4 GO:0002540 leukotriene production involved in inflammatory response(GO:0002540)
0.1 0.3 GO:0006667 sphinganine metabolic process(GO:0006667)
0.1 0.7 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.1 0.2 GO:0046223 mycotoxin metabolic process(GO:0043385) mycotoxin catabolic process(GO:0043387) aflatoxin metabolic process(GO:0046222) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound metabolic process(GO:1901376) organic heteropentacyclic compound catabolic process(GO:1901377)
0.1 0.6 GO:0005513 detection of calcium ion(GO:0005513)
0.1 0.3 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.1 0.3 GO:0035720 intraciliary anterograde transport(GO:0035720)
0.1 0.6 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.1 0.3 GO:0051661 maintenance of centrosome location(GO:0051661) maintenance of Golgi location(GO:0051684)
0.0 0.2 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.0 1.5 GO:0010107 potassium ion import(GO:0010107)
0.0 0.3 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 0.2 GO:0015722 canalicular bile acid transport(GO:0015722)
0.0 0.1 GO:0002430 complement receptor mediated signaling pathway(GO:0002430) tolerance induction dependent upon immune response(GO:0002461)
0.0 0.1 GO:1904776 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.0 0.1 GO:0006538 glutamate catabolic process(GO:0006538)
0.0 0.6 GO:0090023 positive regulation of neutrophil chemotaxis(GO:0090023)
0.0 0.5 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.2 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.0 0.9 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.0 0.1 GO:2000258 negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.0 0.1 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.0 0.3 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.0 0.3 GO:0046548 retinal rod cell development(GO:0046548)
0.0 0.2 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0 0.2 GO:0030828 positive regulation of cGMP biosynthetic process(GO:0030828)
0.0 0.1 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.0 1.1 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.5 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.1 GO:0051533 positive regulation of NFAT protein import into nucleus(GO:0051533)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.5 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.1 0.3 GO:0035841 new growing cell tip(GO:0035841)
0.1 0.3 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.1 0.2 GO:0046691 intracellular canaliculus(GO:0046691)
0.1 0.3 GO:0035339 SPOTS complex(GO:0035339)
0.0 0.7 GO:0001533 cornified envelope(GO:0001533)
0.0 0.9 GO:0000800 lateral element(GO:0000800)
0.0 0.6 GO:0002080 acrosomal membrane(GO:0002080)
0.0 0.2 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.0 0.5 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.3 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 0.2 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.3 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 1.3 GO:0030315 T-tubule(GO:0030315)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.5 GO:0051870 methotrexate binding(GO:0051870)
0.2 0.7 GO:0030280 structural constituent of epidermis(GO:0030280)
0.2 1.2 GO:0070012 oligopeptidase activity(GO:0070012)
0.2 0.5 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.1 0.4 GO:0004051 arachidonate 5-lipoxygenase activity(GO:0004051)
0.1 1.0 GO:0042609 CD4 receptor binding(GO:0042609)
0.1 0.3 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.1 0.3 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.1 0.8 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.1 0.2 GO:0008502 melatonin receptor activity(GO:0008502)
0.1 1.5 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.1 0.6 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.2 GO:0004939 beta-adrenergic receptor activity(GO:0004939) beta-3 adrenergic receptor binding(GO:0031699)
0.0 0.6 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.4 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.6 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.1 GO:0004875 complement receptor activity(GO:0004875)
0.0 0.2 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.2 GO:0015250 water channel activity(GO:0015250)
0.0 0.1 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.1 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 0.1 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0 0.3 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 0.6 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.1 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 1.1 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 1.5 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.6 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.2 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.6 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines