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12D miR HR13_24

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Results for Smad2

Z-value: 0.77

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Transcription factors associated with Smad2

Gene Symbol Gene ID Gene Info
ENSMUSG00000024563.9 SMAD family member 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Smad2mm10_v2_chr18_+_76241580_762417410.766.2e-03Click!

Activity profile of Smad2 motif

Sorted Z-values of Smad2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr15_-_101562889 2.00 ENSMUST00000023714.4
RIKEN cDNA 4732456N10 gene
chr15_+_62178175 1.81 ENSMUST00000182476.1
plasmacytoma variant translocation 1
chr15_+_82252397 0.97 ENSMUST00000136948.1
RIKEN cDNA 1500009C09 gene
chr7_-_116237767 0.88 ENSMUST00000182834.1
pleckstrin homology domain containing, family A member 7
chr19_+_47228804 0.85 ENSMUST00000111807.3
neuralized homolog 1A (Drosophila)
chr9_-_44713196 0.82 ENSMUST00000144251.1
ENSMUST00000156918.1
pleckstrin homology-like domain, family B, member 1
chr4_+_11191726 0.76 ENSMUST00000029866.9
ENSMUST00000108324.3
cyclin E2
chr2_-_91950386 0.75 ENSMUST00000111303.1
diacylglycerol kinase zeta
chr10_-_49788743 0.68 ENSMUST00000105483.1
ENSMUST00000105487.1
glutamate receptor, ionotropic, kainate 2 (beta 2)
chrX_-_7947763 0.64 ENSMUST00000154244.1
histone deacetylase 6
chr10_+_80151154 0.62 ENSMUST00000146516.1
ENSMUST00000144526.1
midnolin
chr18_-_42579652 0.60 ENSMUST00000054738.3
G protein-coupled receptor 151
chr15_-_84123174 0.59 ENSMUST00000019012.3
patatin-like phospholipase domain containing 5
chr9_+_53771499 0.57 ENSMUST00000048670.8
solute carrier family 35, member F2
chr17_+_7925990 0.57 ENSMUST00000036370.7
T cell activation Rho GTPase activating protein
chr3_+_89136572 0.51 ENSMUST00000107482.3
ENSMUST00000127058.1
pyruvate kinase liver and red blood cell
chr17_-_34615965 0.48 ENSMUST00000097345.3
ENSMUST00000015611.7
EGF-like domain 8
chrX_-_7947848 0.46 ENSMUST00000115642.1
ENSMUST00000033501.8
ENSMUST00000145675.1
histone deacetylase 6
chr14_-_20496780 0.45 ENSMUST00000022353.3
MSS51 mitochondrial translational activator
chr1_-_179803625 0.44 ENSMUST00000027768.7
AT hook containing transcription factor 1
chr16_+_32914094 0.43 ENSMUST00000023491.6
ENSMUST00000170899.1
ENSMUST00000171118.1
ENSMUST00000170201.1
ENSMUST00000165616.1
ENSMUST00000135193.2
leucine-rich repeats and calponin homology (CH) domain containing 3
chrX_-_7947553 0.43 ENSMUST00000133349.1
histone deacetylase 6
chr7_+_99267428 0.42 ENSMUST00000068973.4
ENSMUST00000122101.1
microtubule-associated protein 6
chr9_+_44107286 0.42 ENSMUST00000152956.1
ENSMUST00000114815.1
C1q and tumor necrosis factor related protein 5
chr4_+_42950369 0.42 ENSMUST00000084662.5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr4_+_11191354 0.40 ENSMUST00000170901.1
cyclin E2
chr14_-_31168587 0.39 ENSMUST00000036618.7
stabilin 1
chr11_+_69846665 0.37 ENSMUST00000019605.2
phospholipid scramblase 3
chr1_-_172297989 0.32 ENSMUST00000085913.4
ENSMUST00000097464.2
ENSMUST00000137679.1
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr11_+_101119938 0.32 ENSMUST00000043680.8
tubulin, gamma 1
chr11_-_116654245 0.32 ENSMUST00000021166.5
cytoglobin
chr3_+_89136133 0.32 ENSMUST00000047111.6
pyruvate kinase liver and red blood cell
chr4_+_148591482 0.30 ENSMUST00000006611.8
spermidine synthase
chr2_-_148443543 0.30 ENSMUST00000099269.3
CD93 antigen
chr8_-_105637403 0.29 ENSMUST00000182046.1
predicted gene 5914
chr7_+_101321703 0.28 ENSMUST00000174291.1
ENSMUST00000167888.2
ENSMUST00000172662.1
ENSMUST00000173270.1
ENSMUST00000174083.1
START domain containing 10
chr7_+_19411086 0.28 ENSMUST00000003643.1
creatine kinase, muscle
chr13_-_78199757 0.27 ENSMUST00000091458.6
nuclear receptor subfamily 2, group F, member 1
chrX_+_99821021 0.27 ENSMUST00000096363.2
transmembrane protein 28
chr18_+_40258361 0.26 ENSMUST00000091927.4
potassium channel tetramerisation domain containing 16
chr18_+_11839220 0.22 ENSMUST00000171109.1
ENSMUST00000046948.8
CDK5 and Abl enzyme substrate 1
chr7_+_82867327 0.22 ENSMUST00000082237.5
mex3 homolog B (C. elegans)
chr2_+_156863110 0.21 ENSMUST00000029165.3
RIKEN cDNA 1110008F13 gene
chr7_-_45052865 0.21 ENSMUST00000057293.6
proline rich 12
chr12_-_103338314 0.21 ENSMUST00000149431.1
ankyrin repeat and SOCS box-containing 2
chr8_+_66386292 0.20 ENSMUST00000039540.5
ENSMUST00000110253.2
membrane-associated ring finger (C3HC4) 1
chr6_-_142702259 0.19 ENSMUST00000073173.5
ENSMUST00000111771.1
ENSMUST00000087527.4
ENSMUST00000100827.2
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr6_+_83137089 0.18 ENSMUST00000121093.1
ENSMUST00000087938.4
rhotekin
chrX_-_136741155 0.18 ENSMUST00000166930.1
ENSMUST00000113095.1
ENSMUST00000155207.1
ENSMUST00000080411.6
ENSMUST00000169418.1
mortality factor 4 like 2
chr17_-_34615776 0.17 ENSMUST00000168353.2
EGF-like domain 8
chr17_-_35700520 0.16 ENSMUST00000119825.1
discoidin domain receptor family, member 1
chr2_+_128967383 0.15 ENSMUST00000110320.2
ENSMUST00000110319.2
zinc finger CCCH type containing 6
chr8_-_70439557 0.14 ENSMUST00000076615.5
CREB regulated transcription coactivator 1
chr13_+_23752267 0.14 ENSMUST00000091703.2
histone cluster 1, H3b
chr16_-_36642742 0.14 ENSMUST00000135280.1
CD86 antigen
chr16_-_17722879 0.14 ENSMUST00000080936.6
ENSMUST00000012259.7
mediator complex subunit 15
chr12_+_33147754 0.14 ENSMUST00000146040.1
ENSMUST00000125192.1
ataxin 7-like 1
chr11_+_69846610 0.14 ENSMUST00000152566.1
ENSMUST00000108633.2
phospholipid scramblase 3
chr9_-_119578981 0.13 ENSMUST00000117911.1
ENSMUST00000120420.1
sodium channel, voltage-gated, type V, alpha
chrX_-_94123359 0.13 ENSMUST00000137853.1
ENSMUST00000088102.5
ENSMUST00000113927.1
zinc finger protein X-linked
chr11_-_33147400 0.13 ENSMUST00000020507.7
fibroblast growth factor 18
chr7_-_29180699 0.11 ENSMUST00000059642.10
proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
chr10_-_37138863 0.11 ENSMUST00000092584.5
myristoylated alanine rich protein kinase C substrate
chr8_+_110721462 0.10 ENSMUST00000052457.8
metastasis suppressor 1-like
chr7_-_29180454 0.09 ENSMUST00000182328.1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
chr17_+_3397189 0.09 ENSMUST00000072156.6
T cell lymphoma invasion and metastasis 2
chr13_-_104816908 0.09 ENSMUST00000022228.6
CWC27 spliceosome-associated protein homolog (S. cerevisiae)
chr10_+_80150448 0.08 ENSMUST00000153477.1
midnolin
chr14_-_18331855 0.08 ENSMUST00000022296.6
ubiquitin-conjugating enzyme E2E 1
chr17_-_35980197 0.07 ENSMUST00000055454.7
proline-rich polypeptide 3
chr11_-_100762928 0.07 ENSMUST00000107360.2
ENSMUST00000055083.3
hypocretin
chr13_-_100104064 0.06 ENSMUST00000038104.5
B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
chr8_+_109705549 0.05 ENSMUST00000034163.8
zinc finger protein 821
chr8_-_69184177 0.05 ENSMUST00000185176.1
leucine zipper, putative tumor suppressor 1
chr10_+_80300997 0.05 ENSMUST00000140828.1
ENSMUST00000138909.1
adenomatosis polyposis coli 2
chr12_+_55836365 0.04 ENSMUST00000059250.6
breast cancer metastasis-suppressor 1-like
chr12_+_33147693 0.04 ENSMUST00000077456.6
ENSMUST00000110824.2
ataxin 7-like 1
chr17_-_38082999 0.03 ENSMUST00000059560.4
olfactory receptor 131
chr7_+_140176061 0.03 ENSMUST00000055890.5
olfactory receptor 523
chr2_+_177768044 0.03 ENSMUST00000108942.3
predicted gene 14322
chr8_-_90908415 0.02 ENSMUST00000098517.1
predicted gene 6658
chr13_+_104817171 0.02 ENSMUST00000022230.8
splicing regulatory glutamine/lysine-rich protein 1interacting protein 1
chr14_+_21500879 0.01 ENSMUST00000182964.1
K(lysine) acetyltransferase 6B
chr4_-_155010984 0.01 ENSMUST00000105631.2
ENSMUST00000139976.2
ENSMUST00000145662.2
phospholipase C, eta 2
chr6_+_125009665 0.01 ENSMUST00000046064.10
ENSMUST00000152752.1
ENSMUST00000088308.3
ENSMUST00000112425.1
ENSMUST00000084275.5
zinc finger protein 384
chr4_+_117849361 0.00 ENSMUST00000163288.1
solute carrier family 6 (neurotransmitter transporter, glycine), member 9

Network of associatons between targets according to the STRING database.

First level regulatory network of Smad2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0070844 misfolded protein transport(GO:0070843) polyubiquitinated protein transport(GO:0070844) polyubiquitinated misfolded protein transport(GO:0070845) Hsp90 deacetylation(GO:0070846)
0.1 0.9 GO:0045218 zonula adherens maintenance(GO:0045218)
0.1 0.3 GO:1903279 regulation of calcium:sodium antiporter activity(GO:1903279)
0.1 0.8 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.1 0.7 GO:0033132 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.1 0.3 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.1 0.9 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.1 0.8 GO:1904261 regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
0.1 0.3 GO:0015671 oxygen transport(GO:0015671)
0.1 0.7 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 0.1 GO:1902630 regulation of membrane hyperpolarization(GO:1902630)
0.0 0.1 GO:0002644 negative regulation of tolerance induction(GO:0002644)
0.0 0.7 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.0 0.1 GO:0086047 membrane depolarization during Purkinje myocyte cell action potential(GO:0086047)
0.0 0.3 GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.0 0.4 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.0 0.2 GO:0072697 protein localization to cell cortex(GO:0072697)
0.0 1.2 GO:0006270 DNA replication initiation(GO:0006270)
0.0 0.1 GO:1904849 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.0 0.3 GO:1990035 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.0 0.6 GO:0019433 triglyceride catabolic process(GO:0019433)
0.0 0.3 GO:0000212 meiotic spindle organization(GO:0000212)
0.0 0.3 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.0 0.2 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.1 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0 0.2 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.1 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.1 0.7 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.1 0.9 GO:0005915 zonula adherens(GO:0005915)
0.1 0.8 GO:0045180 basal cortex(GO:0045180)
0.0 0.2 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.3 GO:0005827 polar microtubule(GO:0005827)
0.0 0.3 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.4 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.1 GO:0042585 germinal vesicle(GO:0042585)
0.0 0.2 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 1.5 GO:0016235 aggresome(GO:0016235)
0.0 0.9 GO:0097440 apical dendrite(GO:0097440)
0.0 0.3 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.2 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.5 GO:0042903 tubulin deacetylase activity(GO:0042903)
0.3 0.8 GO:0004743 pyruvate kinase activity(GO:0004743)
0.1 0.7 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 0.3 GO:0015275 stretch-activated, cation-selective, calcium channel activity(GO:0015275)
0.1 0.3 GO:0004096 catalase activity(GO:0004096)
0.1 0.9 GO:0070097 delta-catenin binding(GO:0070097)
0.1 0.7 GO:0001727 lipid kinase activity(GO:0001727)
0.1 0.3 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.3 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.6 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.3 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556)
0.0 1.2 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.4 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.1 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 0.2 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.5 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.1 GO:0001156 TFIIIC-class transcription factor binding(GO:0001156)
0.0 0.3 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.9 GO:0045182 translation regulator activity(GO:0045182)
0.0 0.1 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.0 0.2 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 0.1 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 0.1 GO:0008140 cAMP response element binding protein binding(GO:0008140)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 1.5 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 0.9 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.8 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.7 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.3 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.8 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 1.5 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.3 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines