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12D miR HR13_24

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Results for Six4

Z-value: 0.65

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Transcription factors associated with Six4

Gene Symbol Gene ID Gene Info
ENSMUSG00000034460.8 sine oculis-related homeobox 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Six4mm10_v2_chr12_-_73113407_731134560.548.7e-02Click!

Activity profile of Six4 motif

Sorted Z-values of Six4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_29307924 1.55 ENSMUST00000108230.1
ENSMUST00000065181.5
D4, zinc and double PHD fingers family 1
chr6_+_134929118 1.42 ENSMUST00000185152.1
ENSMUST00000184504.1
RP23-45G16.5
chr3_+_94398517 1.17 ENSMUST00000050975.3
leucine rich repeat and Ig domain containing 4
chr6_+_134929089 1.15 ENSMUST00000183867.1
ENSMUST00000184991.1
ENSMUST00000183905.1
RP23-45G16.5
chr13_+_51645232 1.09 ENSMUST00000075853.5
CDC28 protein kinase regulatory subunit 2
chr17_-_12851893 1.06 ENSMUST00000162389.1
ENSMUST00000162119.1
ENSMUST00000159223.1
MAS1 oncogene
chr7_+_29309429 0.95 ENSMUST00000137848.1
D4, zinc and double PHD fingers family 1
chr8_+_94377911 0.60 ENSMUST00000159142.1
predicted gene 15889
chr11_+_85312164 0.54 ENSMUST00000127717.1
protein phosphatase 1D magnesium-dependent, delta isoform
chr3_-_129831374 0.49 ENSMUST00000029643.8
GAR1 ribonucleoprotein homolog (yeast)
chr6_+_50110186 0.47 ENSMUST00000166318.1
ENSMUST00000036236.8
ENSMUST00000036225.8
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
chrX_-_150440887 0.46 ENSMUST00000163233.1
transmembrane protein 29
chr1_+_37890477 0.43 ENSMUST00000027256.5
mitochondrial ribosomal protein L30
chr7_+_28180272 0.42 ENSMUST00000173223.1
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b
chr14_-_89898466 0.42 ENSMUST00000081204.4
predicted gene 10110
chr6_+_7555053 0.41 ENSMUST00000090679.2
ENSMUST00000184986.1
tachykinin 1
chr19_-_10974664 0.41 ENSMUST00000072748.6
membrane-spanning 4-domains, subfamily A, member 10
chr7_+_28180226 0.37 ENSMUST00000172467.1
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b
chr13_-_76385028 0.36 ENSMUST00000099365.1
predicted gene 10760
chr13_+_49504774 0.34 ENSMUST00000051504.7
extracellular matrix protein 2, female organ and adipocyte specific
chr8_+_95703037 0.33 ENSMUST00000073139.7
ENSMUST00000080666.7
N-myc downstream regulated gene 4
chr13_+_54071815 0.32 ENSMUST00000021930.8
sideroflexin 1
chr11_-_45955183 0.32 ENSMUST00000109254.1
tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
chr1_-_131200089 0.30 ENSMUST00000068564.8
Ras association (RalGDS/AF-6) domain family member 5
chr11_-_45955465 0.29 ENSMUST00000011398.6
tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
chr18_+_60212080 0.28 ENSMUST00000031549.5
predicted gene 4951
chr10_-_80918212 0.27 ENSMUST00000057623.7
ENSMUST00000179022.1
lamin B2
chr5_-_145191511 0.26 ENSMUST00000161845.1
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F2
chr9_+_78230644 0.25 ENSMUST00000098537.3
glutathione S-transferase, alpha 1 (Ya)
chr7_-_137314394 0.24 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
early B cell factor 3
chr3_+_145938004 0.24 ENSMUST00000039571.7
RIKEN cDNA 2410004B18 gene
chr7_-_132317198 0.21 ENSMUST00000080215.5
carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
chr9_-_57158288 0.21 ENSMUST00000065358.7
COMM domain containing 4
chr9_+_78289923 0.21 ENSMUST00000119823.1
ENSMUST00000121273.1
predicted gene 10639
chr13_+_73626886 0.20 ENSMUST00000022104.7
telomerase reverse transcriptase
chr2_+_25080316 0.19 ENSMUST00000044078.3
ENSMUST00000114380.2
ectonucleoside triphosphate diphosphohydrolase 8
chr10_-_76442758 0.19 ENSMUST00000001179.5
pericentrin (kendrin)
chr7_+_18991245 0.18 ENSMUST00000130268.1
ENSMUST00000059331.8
ENSMUST00000131087.1
Myb-related transcription factor, partner of profilin
chr19_+_8764934 0.17 ENSMUST00000184663.1
nuclear RNA export factor 1
chr6_+_124931378 0.15 ENSMUST00000032214.7
ENSMUST00000180095.1
myeloid leukemia factor 2
chr3_+_139205658 0.14 ENSMUST00000106239.1
sperm tail PG rich repeat containing 2
chr1_-_180813534 0.13 ENSMUST00000159789.1
ENSMUST00000081026.4
H3 histone, family 3A
chr15_-_66831625 0.12 ENSMUST00000164163.1
src-like adaptor
chr9_-_70503718 0.12 ENSMUST00000034739.5
ring finger 111
chr19_-_38224096 0.12 ENSMUST00000067167.5
FRA10AC1 homolog (human)
chr1_+_54250673 0.12 ENSMUST00000027128.4
coiled-coil domain containing 150
chr11_-_118342500 0.11 ENSMUST00000103024.3
cDNA sequence BC100451
chr19_+_6400523 0.11 ENSMUST00000146831.1
ENSMUST00000035716.8
ENSMUST00000138555.1
ENSMUST00000167240.1
RAS, guanyl releasing protein 2
chr15_+_92051153 0.11 ENSMUST00000169825.1
contactin 1
chr12_-_41485751 0.09 ENSMUST00000043884.4
leucine rich repeat protein 3, neuronal
chr8_+_94214567 0.09 ENSMUST00000079961.6
nucleoporin 93
chr14_-_103843685 0.09 ENSMUST00000172237.1
endothelin receptor type B
chr15_-_79834261 0.08 ENSMUST00000148358.1
chromobox 6
chr1_-_180813591 0.07 ENSMUST00000162118.1
ENSMUST00000159685.1
ENSMUST00000161308.1
H3 histone, family 3A
chr2_-_10048580 0.07 ENSMUST00000026888.4
TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr2_-_91444622 0.06 ENSMUST00000064652.7
ENSMUST00000102594.4
ENSMUST00000094835.2
RIKEN cDNA 1110051M20 gene
chr7_-_127935429 0.05 ENSMUST00000141385.1
ENSMUST00000156152.1
protease, serine, 36
chr19_+_29410919 0.04 ENSMUST00000112576.2
programmed cell death 1 ligand 2
chr10_+_79755103 0.04 ENSMUST00000020577.2
fibroblast growth factor 22
chr16_+_11405648 0.04 ENSMUST00000096273.2
sorting nexin 29
chr2_-_103797617 0.04 ENSMUST00000028607.6
cell cycle associated protein 1
chr5_-_41764493 0.03 ENSMUST00000060820.6
NK3 homeobox 2
chr6_+_115134899 0.03 ENSMUST00000009538.5
ENSMUST00000169345.1
synapsin II
chr3_-_30969399 0.03 ENSMUST00000177992.1
ENSMUST00000129817.2
ENSMUST00000168645.1
ENSMUST00000108255.1
ENSMUST00000064718.5
ENSMUST00000099163.3
polyhomeotic-like 3 (Drosophila)
chr8_-_85067982 0.03 ENSMUST00000177563.1
predicted gene 5741
chr19_+_6400611 0.02 ENSMUST00000113467.1
RAS, guanyl releasing protein 2
chr3_+_139205887 0.00 ENSMUST00000062306.6
sperm tail PG rich repeat containing 2

Network of associatons between targets according to the STRING database.

First level regulatory network of Six4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.1 0.5 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
0.1 1.1 GO:0060732 positive regulation of inositol phosphate biosynthetic process(GO:0060732)
0.1 0.2 GO:1904173 negative regulation of RNA interference(GO:1900369) regulation of histone demethylase activity (H3-K4 specific)(GO:1904173)
0.1 0.2 GO:0031509 telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340)
0.0 0.5 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.0 0.3 GO:2001135 regulation of endocytic recycling(GO:2001135)
0.0 1.1 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.0 0.1 GO:0090521 glomerular visceral epithelial cell migration(GO:0090521)
0.0 0.1 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.2 GO:0009133 nucleoside diphosphate biosynthetic process(GO:0009133)
0.0 0.8 GO:0007520 myoblast fusion(GO:0007520)
0.0 0.1 GO:0014826 vein smooth muscle contraction(GO:0014826)
0.0 0.2 GO:1990403 embryonic brain development(GO:1990403)
0.0 0.3 GO:0080184 response to stilbenoid(GO:0035634) response to phenylpropanoid(GO:0080184)
0.0 1.3 GO:0051965 positive regulation of synapse assembly(GO:0051965)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.5 GO:0071565 nBAF complex(GO:0071565)
0.1 0.5 GO:0001651 dense fibrillar component(GO:0001651)
0.0 0.3 GO:0005638 lamin filament(GO:0005638)
0.0 0.2 GO:0001740 Barr body(GO:0001740)
0.0 0.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 1.1 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.3 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.2 GO:0042405 nuclear inclusion body(GO:0042405)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.2 0.6 GO:0008192 RNA guanylyltransferase activity(GO:0008192)
0.2 1.1 GO:0001595 angiotensin receptor activity(GO:0001595)
0.1 0.3 GO:0070052 collagen V binding(GO:0070052)
0.1 0.5 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.1 0.2 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.1 0.5 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.0 0.1 GO:0004962 endothelin receptor activity(GO:0004962)
0.0 0.2 GO:0003964 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.0 0.5 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.1 GO:0032184 SUMO polymer binding(GO:0032184)
0.0 0.4 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.8 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.2 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis