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12D miR HR13_24

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Results for Egr3

Z-value: 1.03

Motif logo

Transcription factors associated with Egr3

Gene Symbol Gene ID Gene Info
ENSMUSG00000033730.3 early growth response 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Egr3mm10_v2_chr14_+_70077375_70077445-0.874.5e-04Click!

Activity profile of Egr3 motif

Sorted Z-values of Egr3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_109722214 2.78 ENSMUST00000020938.7
family with sequence similarity 20, member A
chr5_+_64970069 1.66 ENSMUST00000031080.8
family with sequence similarity 114, member A1
chr8_+_62951361 1.26 ENSMUST00000119068.1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3
chr17_-_87282793 1.21 ENSMUST00000146560.2
RIKEN cDNA 4833418N02 gene
chr17_-_87282771 1.13 ENSMUST00000161759.1
RIKEN cDNA 4833418N02 gene
chr1_+_125676969 1.10 ENSMUST00000027581.6
G protein-coupled receptor 39
chr7_+_80246375 1.09 ENSMUST00000058266.6
tubulin tyrosine ligase-like family, member 13
chr17_-_29078953 1.07 ENSMUST00000133221.1
tumor protein p53 pathway corepressor 1
chr19_+_16956110 1.03 ENSMUST00000087689.4
prune homolog 2 (Drosophila)
chr3_+_105452326 1.02 ENSMUST00000098761.3
potassium voltage-gated channel, Shal-related family, member 3
chr6_+_42261957 0.99 ENSMUST00000095987.3
transmembrane protein 139
chrX_+_143664290 0.92 ENSMUST00000112868.1
p21 protein (Cdc42/Rac)-activated kinase 3
chr1_-_9299238 0.89 ENSMUST00000140295.1
syntrophin, gamma 1
chr18_-_41951187 0.86 ENSMUST00000070949.4
PRELI domain containing 2
chrX_+_143664365 0.86 ENSMUST00000126592.1
ENSMUST00000156449.1
ENSMUST00000155215.1
ENSMUST00000112865.1
p21 protein (Cdc42/Rac)-activated kinase 3
chrX_-_7574120 0.82 ENSMUST00000045924.7
ENSMUST00000115742.2
ENSMUST00000150787.1
protein phosphatase 1, regulatory (inhibitor) subunit 3F
chrX_+_36195968 0.82 ENSMUST00000115256.1
zinc finger, CCHC domain containing 12
chr1_+_120340569 0.81 ENSMUST00000037286.8
complement component 1, q subcomponent-like 2
chr7_-_19023538 0.81 ENSMUST00000036018.5
forkhead box A3
chr2_+_105127200 0.76 ENSMUST00000139585.1
Wilms tumor 1 homolog
chr11_+_71750680 0.76 ENSMUST00000021168.7
WSC domain containing 1
chr9_+_75410145 0.75 ENSMUST00000180533.1
ENSMUST00000180574.1
RIKEN cDNA 4933433G15 gene
chr11_+_71750980 0.73 ENSMUST00000108511.1
WSC domain containing 1
chr9_-_55048544 0.71 ENSMUST00000034854.6
cholinergic receptor, nicotinic, beta polypeptide 4
chrX_-_162159717 0.67 ENSMUST00000087085.3
Nance-Horan syndrome (human)
chr10_+_59221945 0.63 ENSMUST00000182161.1
sosondowah ankyrin repeat domain family member C
chr7_-_110061319 0.62 ENSMUST00000098110.2
expressed sequence AA474408
chr1_-_157412576 0.61 ENSMUST00000078308.6
ENSMUST00000139470.1
RAS protein activator like 2
chr9_-_75409951 0.61 ENSMUST00000049355.10
mitogen-activated protein kinase 6
chr18_-_37935403 0.58 ENSMUST00000080033.6
ENSMUST00000115631.1
diaphanous homolog 1 (Drosophila)
chr18_-_37935378 0.58 ENSMUST00000025337.7
diaphanous homolog 1 (Drosophila)
chr5_+_102481546 0.56 ENSMUST00000112854.1
Rho GTPase activating protein 24
chr12_-_51971289 0.53 ENSMUST00000040583.5
HEAT repeat containing 5A
chr18_-_37935429 0.52 ENSMUST00000115634.1
diaphanous homolog 1 (Drosophila)
chr7_-_45510400 0.52 ENSMUST00000033096.7
nucleobindin 1
chr3_+_97901190 0.52 ENSMUST00000029476.2
ENSMUST00000122288.1
SEC22 vesicle trafficking protein homolog B (S. cerevisiae)
chr17_-_83631892 0.51 ENSMUST00000051482.1
potassium voltage-gated channel, subfamily G, member 3
chr4_-_126968124 0.48 ENSMUST00000106108.2
zinc finger, MYM-type 4
chr10_-_18023229 0.47 ENSMUST00000020002.7
ABRA C-terminal like
chr4_-_129696579 0.46 ENSMUST00000137640.1
transmembrane protein 39b
chr7_+_48959089 0.46 ENSMUST00000183659.1
neuron navigator 2
chr2_-_63184253 0.45 ENSMUST00000075052.3
ENSMUST00000112454.1
potassium voltage-gated channel, subfamily H (eag-related), member 7
chr2_+_121413775 0.45 ENSMUST00000028683.7
protein disulfide isomerase associated 3
chr19_-_47157764 0.41 ENSMUST00000178630.1
calcium homeostasis modulator 3
chr14_+_15437623 0.40 ENSMUST00000181388.1
RIKEN cDNA B230110C06 gene
chr5_-_62765618 0.39 ENSMUST00000159470.1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr7_+_80246529 0.39 ENSMUST00000107381.1
tubulin tyrosine ligase-like family, member 13
chr16_-_94370994 0.39 ENSMUST00000113914.1
ENSMUST00000113905.1
phosphatidylinositol glycan anchor biosynthesis, class P
chr7_+_3645267 0.38 ENSMUST00000038913.9
CCR4-NOT transcription complex, subunit 3
chr5_+_143403819 0.38 ENSMUST00000110731.2
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
chr17_-_28560704 0.37 ENSMUST00000114785.1
ENSMUST00000025062.3
colipase, pancreatic
chr18_+_65698253 0.37 ENSMUST00000115097.1
ENSMUST00000117694.1
O-acyltransferase like
chr4_+_40948401 0.37 ENSMUST00000030128.5
charged multivesicular body protein 5
chr19_+_6400611 0.37 ENSMUST00000113467.1
RAS, guanyl releasing protein 2
chr5_+_138280516 0.35 ENSMUST00000048028.8
stromal antigen 3
chr2_+_4300462 0.33 ENSMUST00000175669.1
FERM domain containing 4A
chr6_+_91684061 0.33 ENSMUST00000032185.7
solute carrier family 6 (neurotransmitter transporter, taurine), member 6
chr11_-_99422252 0.33 ENSMUST00000017741.3
keratin 12
chr7_-_141539784 0.31 ENSMUST00000118694.1
ENSMUST00000153191.1
ENSMUST00000166082.1
ENSMUST00000026586.6
chitinase domain containing 1
chr14_-_21740395 0.31 ENSMUST00000120984.2
dual specificity phosphatase 13
chr9_-_58204310 0.31 ENSMUST00000114144.2
immunoglobulin superfamily containing leucine-rich repeat 2
chr4_+_99955715 0.30 ENSMUST00000102783.4
phosphoglucomutase 2
chr16_+_64851991 0.29 ENSMUST00000067744.7
CGG triplet repeat binding protein 1
chr17_-_33760306 0.26 ENSMUST00000173860.1
RAB11B, member RAS oncogene family
chrX_+_101274198 0.25 ENSMUST00000117203.1
ENSMUST00000087948.4
ENSMUST00000087956.5
mediator of RNA polymerase II transcription, subunit 12 homolog (yeast)
chrX_+_101274023 0.25 ENSMUST00000117706.1
mediator of RNA polymerase II transcription, subunit 12 homolog (yeast)
chr17_-_79715034 0.25 ENSMUST00000024894.1
cytochrome P450, family 1, subfamily b, polypeptide 1
chr7_+_144896523 0.24 ENSMUST00000033389.5
fibroblast growth factor 15
chr14_+_55510445 0.24 ENSMUST00000165262.1
ENSMUST00000074225.4
copine VI
chr3_-_127162328 0.23 ENSMUST00000182994.1
ankyrin 2, brain
chr5_+_77265454 0.22 ENSMUST00000080359.5
RE1-silencing transcription factor
chr9_+_44499126 0.22 ENSMUST00000074989.5
B cell CLL/lymphoma 9-like
chr9_-_66124872 0.22 ENSMUST00000034946.8
sorting nexin 1
chr13_+_59585259 0.22 ENSMUST00000168367.1
ENSMUST00000022038.7
ENSMUST00000166923.1
N(alpha)-acetyltransferase 35, NatC auxiliary subunit
chr10_+_29143996 0.21 ENSMUST00000092629.2
SOGA family member 3
chr19_-_4615453 0.21 ENSMUST00000053597.2
leucine rich repeat and fibronectin type III domain containing 4
chr3_+_135438722 0.20 ENSMUST00000166033.1
ubiquitin-conjugating enzyme E2D 3
chr17_+_87282880 0.20 ENSMUST00000041110.5
ENSMUST00000125875.1
tetratricopeptide repeat domain 7
chr2_+_32395896 0.20 ENSMUST00000028162.3
prostaglandin E synthase 2
chr3_-_81975742 0.20 ENSMUST00000029645.8
tryptophan 2,3-dioxygenase
chr4_-_41695935 0.19 ENSMUST00000145379.1
ciliary neurotrophic factor receptor
chr5_+_138280538 0.19 ENSMUST00000162245.1
ENSMUST00000161691.1
stromal antigen 3
chr1_+_74506044 0.18 ENSMUST00000087215.5
rcd1 (required for cell differentiation) homolog 1 (S. pombe)
chr2_-_173119402 0.17 ENSMUST00000094287.3
ENSMUST00000179693.1
CCCTC-binding factor (zinc finger protein)-like
chr12_-_67221221 0.16 ENSMUST00000178814.1
ENSMUST00000179345.2
MAM domain containing glycosylphosphatidylinositol anchor 2
MAM domain-containing glycosylphosphatidylinositol anchor protein 2
chr1_+_36068371 0.15 ENSMUST00000088174.3
heparan sulfate 6-O-sulfotransferase 1
chr6_+_125067913 0.15 ENSMUST00000088292.5
lysophosphatidic acid receptor 5
chr13_-_41847599 0.15 ENSMUST00000179758.1
androgen dependent TFPI regulating protein
chr18_+_32163073 0.15 ENSMUST00000096575.3
mitogen-activated protein kinase kinase kinase 2
chr13_-_41847626 0.14 ENSMUST00000121404.1
androgen dependent TFPI regulating protein
chr18_-_84086379 0.12 ENSMUST00000060303.8
teashirt zinc finger family member 1
chr15_-_98778150 0.11 ENSMUST00000023732.5
wingless related MMTV integration site 10b
chr13_-_85288999 0.11 ENSMUST00000109552.2
RAS p21 protein activator 1
chr10_+_83722865 0.08 ENSMUST00000150459.1
RIKEN cDNA 1500009L16 gene
chr13_+_55369732 0.08 ENSMUST00000063771.7
regulator of G-protein signaling 14
chr19_+_6975048 0.07 ENSMUST00000070850.6
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr3_+_129213920 0.07 ENSMUST00000042587.10
paired-like homeodomain transcription factor 2
chr7_-_100371889 0.07 ENSMUST00000032963.8
protein phosphatase methylesterase 1
chr17_-_46327990 0.06 ENSMUST00000167360.1
ATP-binding cassette, sub-family C (CFTR/MRP), member 10
chr19_-_4615647 0.05 ENSMUST00000113822.2
leucine rich repeat and fibronectin type III domain containing 4
chr7_-_119184374 0.05 ENSMUST00000084650.4
G protein-coupled receptor 139
chr13_-_41847482 0.04 ENSMUST00000072012.3
androgen dependent TFPI regulating protein
chr17_-_46327949 0.03 ENSMUST00000047970.7
ATP-binding cassette, sub-family C (CFTR/MRP), member 10
chr10_-_111010001 0.02 ENSMUST00000099285.3
ENSMUST00000041723.7
zinc finger, DHHC domain containing 17
chr11_-_98775333 0.02 ENSMUST00000064941.6
nuclear receptor subfamily 1, group D, member 1
chr10_-_29144194 0.01 ENSMUST00000070359.2
predicted gene 9996
chr4_+_123183722 0.00 ENSMUST00000152194.1
hippocalcin-like 4

Network of associatons between targets according to the STRING database.

First level regulatory network of Egr3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:0035482 gastric motility(GO:0035482)
0.3 0.8 GO:0072302 negative regulation of metanephric glomerulus development(GO:0072299) negative regulation of metanephric glomerular mesangial cell proliferation(GO:0072302) regulation of metanephric ureteric bud development(GO:2001074) positive regulation of metanephric ureteric bud development(GO:2001076)
0.2 0.7 GO:0060084 synaptic transmission involved in micturition(GO:0060084)
0.2 2.8 GO:0070166 enamel mineralization(GO:0070166)
0.2 0.8 GO:0070368 positive regulation of hepatocyte differentiation(GO:0070368)
0.2 0.8 GO:2000325 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.1 0.4 GO:1903334 positive regulation of protein folding(GO:1903334)
0.1 0.5 GO:0007066 female meiosis sister chromatid cohesion(GO:0007066)
0.1 0.4 GO:0061763 multivesicular body-lysosome fusion(GO:0061763)
0.1 0.5 GO:0021564 vagus nerve development(GO:0021564)
0.1 1.3 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 1.0 GO:0097623 potassium ion export across plasma membrane(GO:0097623)
0.1 0.2 GO:0071603 endothelial cell-cell adhesion(GO:0071603)
0.1 0.3 GO:0006032 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.1 0.5 GO:0090245 axis elongation involved in somitogenesis(GO:0090245)
0.1 1.8 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.1 0.2 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.1 0.3 GO:0045054 constitutive secretory pathway(GO:0045054)
0.1 0.8 GO:2000465 regulation of glycogen (starch) synthase activity(GO:2000465)
0.1 0.6 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.1 0.2 GO:2000705 regulation of dense core granule biogenesis(GO:2000705)
0.1 0.4 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 0.2 GO:0003360 brainstem development(GO:0003360)
0.0 0.2 GO:0070858 negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252)
0.0 0.1 GO:0060023 soft palate development(GO:0060023)
0.0 0.5 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 0.3 GO:0019388 galactose catabolic process(GO:0019388)
0.0 0.3 GO:0061303 cornea development in camera-type eye(GO:0061303)
0.0 0.2 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.1 GO:0051885 positive regulation of anagen(GO:0051885)
0.0 0.2 GO:0036309 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.0 0.2 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 0.1 GO:0021763 subthalamic nucleus development(GO:0021763) superior vena cava morphogenesis(GO:0060578)
0.0 0.4 GO:0032094 response to food(GO:0032094)
0.0 0.2 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.0 0.7 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)
0.0 0.4 GO:0001829 trophectodermal cell differentiation(GO:0001829)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0000802 transverse filament(GO:0000802)
0.1 0.5 GO:0090498 extrinsic component of Golgi membrane(GO:0090498)
0.1 0.2 GO:0030905 retromer, tubulation complex(GO:0030905)
0.1 0.2 GO:0031417 NatC complex(GO:0031417)
0.1 0.4 GO:0042825 TAP complex(GO:0042825)
0.0 0.7 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.2 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.0 0.4 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.7 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 1.0 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.6 GO:0032156 septin cytoskeleton(GO:0032156)
0.0 0.4 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.5 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.5 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.5 GO:0016592 mediator complex(GO:0016592)
0.0 0.8 GO:0005758 mitochondrial intermembrane space(GO:0005758)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.2 0.8 GO:2001069 glycogen binding(GO:2001069)
0.2 1.0 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.1 0.4 GO:0019153 protein-disulfide reductase (glutathione) activity(GO:0019153)
0.1 0.3 GO:0030977 taurine binding(GO:0030977)
0.1 0.8 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.1 0.4 GO:0046923 ER retention sequence binding(GO:0046923)
0.1 1.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 1.5 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 0.3 GO:0004568 chitinase activity(GO:0004568)
0.1 2.8 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.1 0.2 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.1 0.2 GO:1990460 leptin receptor binding(GO:1990460)
0.1 0.7 GO:0042166 acetylcholine-gated cation channel activity(GO:0022848) acetylcholine binding(GO:0042166)
0.1 0.2 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.0 0.3 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 0.2 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.0 0.6 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.2 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.4 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.2 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.0 1.5 GO:0008146 sulfotransferase activity(GO:0008146)
0.0 0.5 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.6 GO:0032183 SUMO binding(GO:0032183)
0.0 0.4 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 0.2 GO:0070330 aromatase activity(GO:0070330)
0.0 0.2 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.5 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.0 0.6 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.3 GO:0031489 myosin V binding(GO:0031489)
0.0 0.5 GO:0005484 SNAP receptor activity(GO:0005484)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.8 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 1.3 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.8 PID HNF3A PATHWAY FOXA1 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 2.0 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.4 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.2 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.0 0.8 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.3 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.3 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.4 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.4 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0 0.4 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.2 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.2 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.4 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling