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12D miR HR13_24

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Results for Nkx2-4

Z-value: 0.82

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Transcription factors associated with Nkx2-4

Gene Symbol Gene ID Gene Info
ENSMUSG00000054160.2 NK2 homeobox 4

Activity profile of Nkx2-4 motif

Sorted Z-values of Nkx2-4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr10_+_4611971 3.59 ENSMUST00000105590.1
ENSMUST00000067086.7
estrogen receptor 1 (alpha)
chr14_-_47418407 1.76 ENSMUST00000043296.3
discs, large (Drosophila) homolog-associated protein 5
chr10_+_88091070 1.67 ENSMUST00000048621.7
pro-melanin-concentrating hormone
chr9_+_108560422 1.51 ENSMUST00000081111.8
inosine 5'-phosphate dehydrogenase 2
chr6_-_29165003 1.44 ENSMUST00000007993.9
RNA binding motif protein 28
chr6_+_134929118 1.40 ENSMUST00000185152.1
ENSMUST00000184504.1
RP23-45G16.5
chr6_+_21986887 1.30 ENSMUST00000151315.1
cadherin-like and PC-esterase domain containing 1
chr7_-_34812677 1.25 ENSMUST00000078686.6
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
chr6_+_134929089 1.24 ENSMUST00000183867.1
ENSMUST00000184991.1
ENSMUST00000183905.1
RP23-45G16.5
chr6_+_21986438 1.17 ENSMUST00000115382.1
cadherin-like and PC-esterase domain containing 1
chr10_+_20347788 0.97 ENSMUST00000169712.1
mitochondrial fission regulator 2
chr13_+_108316395 0.96 ENSMUST00000171178.1
DEP domain containing 1B
chr2_+_131950855 0.88 ENSMUST00000110170.1
ENSMUST00000110172.2
ENSMUST00000110171.2
prion protein dublet
chr8_+_66860215 0.77 ENSMUST00000118009.1
nuclear assembly factor 1 homolog (S. cerevisiae)
chr2_+_30061754 0.69 ENSMUST00000149578.1
ENSMUST00000102866.3
SET nuclear oncogene
chr6_+_123229843 0.59 ENSMUST00000112554.2
ENSMUST00000024118.4
ENSMUST00000117130.1
C-type lectin domain family 4, member n
chr12_+_38781093 0.58 ENSMUST00000161513.1
ets variant gene 1
chr12_+_38780817 0.57 ENSMUST00000160856.1
ets variant gene 1
chr10_+_128232065 0.57 ENSMUST00000055539.4
ENSMUST00000105244.1
ENSMUST00000105243.2
ENSMUST00000125289.1
ENSMUST00000105242.1
timeless circadian clock 1
chr12_-_91746020 0.53 ENSMUST00000166967.1
stonin 2
chr13_+_3478226 0.53 ENSMUST00000181708.1
ENSMUST00000180836.1
ENSMUST00000180567.1
RIKEN cDNA 2810429I04 gene
chr4_-_108848619 0.53 ENSMUST00000164855.1
RIKEN cDNA A730015C16 gene
chr2_+_25180737 0.50 ENSMUST00000104999.2
Notch-regulated ankyrin repeat protein
chr9_-_71896047 0.50 ENSMUST00000184448.1
transcription factor 12
chr1_+_34439851 0.49 ENSMUST00000027303.7
IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast)
chr7_-_81566939 0.46 ENSMUST00000042318.5
fibronectin type III and SPRY domain containing 2
chr12_+_69963452 0.44 ENSMUST00000110560.1
predicted gene 3086
chr2_-_27507656 0.43 ENSMUST00000154316.1
bromodomain containing 3
chr2_-_34755229 0.43 ENSMUST00000102800.1
GTPase activating protein and VPS9 domains 1
chr8_+_45628176 0.42 ENSMUST00000130850.1
sorbin and SH3 domain containing 2
chr4_-_136892867 0.42 ENSMUST00000046332.5
complement component 1, q subcomponent, C chain
chr4_+_48663502 0.39 ENSMUST00000030033.4
muscle-related coiled-coil protein
chr2_+_140170641 0.35 ENSMUST00000044825.4
NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
chr8_+_31091593 0.35 ENSMUST00000161713.1
dual specificity phosphatase 26 (putative)
chr17_-_25844417 0.34 ENSMUST00000176591.1
ras homolog gene family, member T2
chr7_-_132813095 0.34 ENSMUST00000106165.1
family with sequence similarity 53, member B
chr13_+_108860072 0.34 ENSMUST00000177907.1
phosphodiesterase 4D, cAMP specific
chr7_-_80905060 0.32 ENSMUST00000119428.1
ENSMUST00000026817.4
neuromedin B
chr8_+_46490968 0.31 ENSMUST00000110372.1
ENSMUST00000130563.1
acyl-CoA synthetase long-chain family member 1
chr11_+_70026815 0.29 ENSMUST00000135916.2
discs, large homolog 4 (Drosophila)
chrX_+_37265338 0.28 ENSMUST00000115194.3
reproductive homeobox 4A
chr3_-_110250963 0.28 ENSMUST00000106567.1
protein arginine N-methyltransferase 6
chr4_+_99656299 0.27 ENSMUST00000087285.3
forkhead box D3
chr1_+_85650008 0.27 ENSMUST00000054279.8
ENSMUST00000147552.1
ENSMUST00000153574.1
ENSMUST00000150967.1
nuclear antigen Sp100
chr11_+_87592897 0.27 ENSMUST00000119628.1
myotubularin related protein 4
chr18_+_34542313 0.27 ENSMUST00000012426.2
wingless-related MMTV integration site 8A
chr2_+_174643534 0.26 ENSMUST00000059452.5
zinc finger protein 831
chr5_+_89027959 0.26 ENSMUST00000130041.1
solute carrier family 4 (anion exchanger), member 4
chr17_+_16972910 0.25 ENSMUST00000071374.5
cDNA sequence BC002059
chr2_-_85196697 0.25 ENSMUST00000099930.2
ENSMUST00000111601.1
leucine rich repeat containing 55
chr1_+_85649988 0.25 ENSMUST00000155094.1
nuclear antigen Sp100
chr11_+_53720790 0.23 ENSMUST00000048605.2
interleukin 5
chr15_-_98898483 0.23 ENSMUST00000023737.4
desert hedgehog
chr1_-_118311132 0.22 ENSMUST00000027623.7
translin
chrX_+_37390848 0.21 ENSMUST00000179915.2
predicted gene, 21098
chrX_-_155623325 0.21 ENSMUST00000038665.5
patched domain containing 1
chr3_+_88629499 0.19 ENSMUST00000175745.1
rho/rac guanine nucleotide exchange factor (GEF) 2
chr2_-_85035487 0.19 ENSMUST00000028465.7
purinergic receptor P2X, ligand-gated ion channel, 3
chr7_+_82867327 0.17 ENSMUST00000082237.5
mex3 homolog B (C. elegans)
chr5_-_137533170 0.17 ENSMUST00000168746.1
ENSMUST00000170293.1
guanine nucleotide binding protein (G protein), beta 2
chr11_-_102579461 0.16 ENSMUST00000107081.1
predicted gene 11627
chr10_-_26373956 0.15 ENSMUST00000105519.3
ENSMUST00000040219.6
l(3)mbt-like 3 (Drosophila)
chr4_-_40279389 0.15 ENSMUST00000108108.2
ENSMUST00000095128.3
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6
chr13_+_47193942 0.14 ENSMUST00000110111.2
ring finger protein 144B
chr19_-_5457397 0.14 ENSMUST00000179549.1
coiled-coil domain containing 85B
chr8_+_45627946 0.14 ENSMUST00000145458.1
sorbin and SH3 domain containing 2
chr15_+_99055164 0.14 ENSMUST00000047104.7
ENSMUST00000024249.3
peripherin
chr12_-_105685235 0.13 ENSMUST00000041055.7
autophagy related 2B
chr14_+_55672235 0.12 ENSMUST00000002397.5
guanosine monophosphate reductase 2
chr1_+_85650044 0.12 ENSMUST00000066427.4
nuclear antigen Sp100
chr5_-_137533297 0.12 ENSMUST00000111020.1
ENSMUST00000111023.1
guanine nucleotide binding protein (G protein), beta 2
chr17_-_40914350 0.12 ENSMUST00000166343.1
glycine-N-acyltransferase-like 3
chr5_-_64932761 0.11 ENSMUST00000059349.4
toll-like receptor 1
chr8_-_40308331 0.11 ENSMUST00000118639.1
fibroblast growth factor 20
chr5_-_137533212 0.11 ENSMUST00000143495.1
ENSMUST00000111038.1
guanine nucleotide binding protein (G protein), beta 2
erythropoietin
chr17_+_36943025 0.11 ENSMUST00000173072.1
ring finger protein 39
chr5_+_34999111 0.08 ENSMUST00000114283.1
regulator of G-protein signaling 12
chr19_-_39740999 0.08 ENSMUST00000099472.3
cytochrome P450, family 2, subfamily c, polypeptide 68
chr5_+_89028035 0.07 ENSMUST00000113216.2
ENSMUST00000134303.1
solute carrier family 4 (anion exchanger), member 4
chr8_+_88199194 0.07 ENSMUST00000119033.1
ENSMUST00000066748.3
ENSMUST00000118952.1
PAP associated domain containing 5
chr11_+_101733011 0.07 ENSMUST00000129741.1
DEAH (Asp-Glu-Ala-His) box polypeptide 8
chr17_+_86753900 0.07 ENSMUST00000024954.9
endothelial PAS domain protein 1
chr17_-_25844514 0.07 ENSMUST00000176709.1
ras homolog gene family, member T2
chrX_+_37557412 0.06 ENSMUST00000089075.4
reproductive homeobox 4E
chr15_-_100669496 0.06 ENSMUST00000182814.1
ENSMUST00000182068.1
bridging integrator 2
chr15_-_100669535 0.06 ENSMUST00000183211.1
bridging integrator 2
chr6_-_122609964 0.05 ENSMUST00000032211.4
growth differentiation factor 3
chrX_-_140956675 0.05 ENSMUST00000033805.8
ENSMUST00000112978.1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
chr14_-_55671873 0.04 ENSMUST00000163750.1
ENSMUST00000010520.8
neural precursor cell expressed, developmentally down-regulated gene 8
chrX_+_107089234 0.03 ENSMUST00000118666.1
ENSMUST00000053375.3
purinergic receptor P2Y, G-protein coupled 10
chr3_+_76593550 0.03 ENSMUST00000162471.1
follistatin-like 5
chr15_-_100669512 0.03 ENSMUST00000182574.1
ENSMUST00000182775.1
bridging integrator 2
chr1_+_178798438 0.02 ENSMUST00000160789.1
kinesin family member 26B
chr15_-_26895049 0.02 ENSMUST00000059204.9
F-box and leucine-rich repeat protein 7
chr16_+_32419696 0.02 ENSMUST00000014220.8
ENSMUST00000080316.7
Tctex1 domain containing 2
chr11_+_101732950 0.02 ENSMUST00000039152.7
DEAH (Asp-Glu-Ala-His) box polypeptide 8
chr6_-_91807318 0.02 ENSMUST00000159684.1
glutamate receptor interacting protein 2
chr11_-_83429455 0.02 ENSMUST00000052521.2
growth arrest-specific 2 like 2
chr2_-_93046053 0.02 ENSMUST00000111272.1
ENSMUST00000178666.1
ENSMUST00000147339.1
PR domain containing 11
chr2_-_147186389 0.01 ENSMUST00000109970.3
ENSMUST00000067075.5
NK2 homeobox 2
chr5_-_23616528 0.01 ENSMUST00000088392.4
serine/arginine-rich protein specific kinase 2
chr6_-_91807424 0.01 ENSMUST00000162300.1
glutamate receptor interacting protein 2
chr11_+_110968056 0.01 ENSMUST00000125692.1
potassium inwardly-rectifying channel, subfamily J, member 16
chrX_+_112604274 0.01 ENSMUST00000071814.6
zinc finger protein 711
chr8_+_45627709 0.00 ENSMUST00000134321.1
ENSMUST00000135336.1
sorbin and SH3 domain containing 2

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx2-4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 3.6 GO:0060523 prostate epithelial cord elongation(GO:0060523)
0.3 1.5 GO:0006177 GMP biosynthetic process(GO:0006177)
0.2 1.7 GO:0042320 negative regulation of synaptic transmission, dopaminergic(GO:0032227) regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747)
0.2 0.6 GO:1904975 response to bleomycin(GO:1904975) cellular response to bleomycin(GO:1904976)
0.2 0.8 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454) telomerase RNA stabilization(GO:0090669)
0.1 0.4 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.1 1.1 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1 0.2 GO:0045645 regulation of eosinophil differentiation(GO:0045643) positive regulation of eosinophil differentiation(GO:0045645)
0.1 0.3 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.1 0.4 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
0.0 0.3 GO:0009946 proximal/distal axis specification(GO:0009946)
0.0 0.5 GO:0014807 regulation of somitogenesis(GO:0014807)
0.0 0.9 GO:0006878 cellular copper ion homeostasis(GO:0006878)
0.0 0.1 GO:0071725 detection of bacterial lipopeptide(GO:0070340) response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727)
0.0 0.2 GO:1904058 positive regulation of sensory perception of pain(GO:1904058)
0.0 0.1 GO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.0 0.1 GO:1901069 guanosine-containing compound catabolic process(GO:1901069)
0.0 0.3 GO:1901898 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.2 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.0 0.3 GO:0098953 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
0.0 0.3 GO:0044539 long-chain fatty acid import(GO:0044539)
0.0 0.2 GO:0072697 protein localization to cell cortex(GO:0072697)
0.0 0.6 GO:0050832 defense response to fungus(GO:0050832)
0.0 0.4 GO:0018195 peptidyl-arginine modification(GO:0018195)
0.0 0.2 GO:1903818 positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.0 0.4 GO:0047497 establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.0 1.0 GO:0000266 mitochondrial fission(GO:0000266)
0.0 0.1 GO:1903181 regulation of dopamine biosynthetic process(GO:1903179) positive regulation of dopamine biosynthetic process(GO:1903181)
0.0 0.1 GO:0038032 termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.0 0.0 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.0 0.3 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.2 GO:0033327 Leydig cell differentiation(GO:0033327)
0.0 0.3 GO:0016486 peptide hormone processing(GO:0016486)
0.0 0.2 GO:0043249 erythrocyte maturation(GO:0043249)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.6 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.2 0.5 GO:0034457 Mpp10 complex(GO:0034457)
0.1 1.8 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 0.4 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 0.1 GO:0044299 C-fiber(GO:0044299)
0.0 0.8 GO:0005732 small nucleolar ribonucleoprotein complex(GO:0005732)
0.0 1.8 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.4 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.3 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.2 GO:0005639 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.6 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.4 1.5 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.2 1.2 GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.2 0.5 GO:0030519 snoRNP binding(GO:0030519)
0.1 0.4 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.1 0.3 GO:0043758 acetate-CoA ligase (ADP-forming) activity(GO:0043758)
0.1 0.3 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241) histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.1 2.0 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.8 GO:0070034 telomerase RNA binding(GO:0070034)
0.0 0.2 GO:0005113 patched binding(GO:0005113)
0.0 0.1 GO:0035663 Toll-like receptor 2 binding(GO:0035663)
0.0 0.1 GO:0005128 erythropoietin receptor binding(GO:0005128)
0.0 0.3 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.0 0.2 GO:0004931 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 0.6 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.5 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.3 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.3 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.4 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.9 GO:0005507 copper ion binding(GO:0005507)
0.0 0.1 GO:0050897 cobalt ion binding(GO:0050897)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.6 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 1.8 PID AURORA A PATHWAY Aurora A signaling
0.0 1.1 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.6 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.2 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 3.6 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.1 0.4 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.1 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 0.3 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.3 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 2.0 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.5 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.4 REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR Genes involved in Thromboxane signalling through TP receptor