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12D miR HR13_24

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Results for Lhx3

Z-value: 0.58

Motif logo

Transcription factors associated with Lhx3

Gene Symbol Gene ID Gene Info
ENSMUSG00000026934.9 LIM homeobox protein 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Lhx3mm10_v2_chr2_-_26208281_26208293-0.831.4e-03Click!

Activity profile of Lhx3 motif

Sorted Z-values of Lhx3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_60081861 0.92 ENSMUST00000029326.5
succinate receptor 1
chr6_+_96115249 0.92 ENSMUST00000075080.5
family with sequence similarity 19, member A1
chr17_+_69439326 0.89 ENSMUST00000169935.1
RIKEN cDNA A330050F15 gene
chr14_-_108914237 0.74 ENSMUST00000100322.2
SLIT and NTRK-like family, member 1
chr4_+_102589687 0.70 ENSMUST00000097949.4
ENSMUST00000106901.1
phosphodiesterase 4B, cAMP specific
chr19_-_34166037 0.65 ENSMUST00000025686.7
ankyrin repeat domain 22
chr6_-_3399545 0.54 ENSMUST00000120087.3
sterile alpha motif domain containing 9-like
chr10_-_64090265 0.47 ENSMUST00000105439.1
leucine rich repeat transmembrane neuronal 3
chr6_-_115592571 0.46 ENSMUST00000112957.1
RIKEN cDNA 2510049J12 gene
chr11_+_59306920 0.46 ENSMUST00000000128.3
ENSMUST00000108783.3
wingless-type MMTV integration site 9A
chr18_-_38866702 0.46 ENSMUST00000115582.1
fibroblast growth factor 1
chr6_+_34780412 0.44 ENSMUST00000115016.1
ENSMUST00000115017.1
ATP/GTP binding protein-like 3
chr6_-_129876659 0.41 ENSMUST00000014687.4
ENSMUST00000122219.1
killer cell lectin-like receptor, subfamily A, member 17
chr4_-_58499398 0.41 ENSMUST00000107570.1
lysophosphatidic acid receptor 1
chr10_-_53647080 0.40 ENSMUST00000169866.1
family with sequence similarity 184, member A
chr17_-_36032682 0.39 ENSMUST00000102678.4
histocompatibility 2, T region locus 23
chr11_-_49113757 0.36 ENSMUST00000060398.1
olfactory receptor 1396
chr15_-_58364148 0.35 ENSMUST00000068515.7
annexin A13
chr11_+_62847111 0.34 ENSMUST00000150989.1
ENSMUST00000176577.1
F-box and WD-40 domain protein 10
chr7_+_45621805 0.34 ENSMUST00000033100.4
izumo sperm-egg fusion 1
chr10_+_75037066 0.34 ENSMUST00000147802.1
ENSMUST00000020391.5
RAB36, member RAS oncogene family
chr4_+_145585166 0.33 ENSMUST00000105739.1
ENSMUST00000119718.1
predicted gene 13212
chr3_+_151437887 0.32 ENSMUST00000046977.7
EGF, latrophilin seven transmembrane domain containing 1
chr7_-_119459266 0.30 ENSMUST00000033255.5
glycoprotein 2 (zymogen granule membrane)
chrX_-_143933204 0.29 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
doublecortin
chr2_+_125136692 0.29 ENSMUST00000099452.2
cortexin 2
chr4_-_147702553 0.29 ENSMUST00000117638.1
zinc finger protein 534
chr15_+_98571004 0.28 ENSMUST00000023728.6
RIKEN cDNA 4930415O20 gene
chr10_-_24101951 0.27 ENSMUST00000170267.1
trace amine-associated receptor 8C
chr5_-_70842617 0.27 ENSMUST00000031119.1
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1
chr5_+_66968961 0.27 ENSMUST00000132991.1
LIM and calponin homology domains 1
chr5_+_20702129 0.26 ENSMUST00000101556.4
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr10_+_102158858 0.26 ENSMUST00000138522.1
ENSMUST00000163753.1
ENSMUST00000138016.1
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr18_+_57468478 0.26 ENSMUST00000091892.2
cortexin 3
chr10_+_23797052 0.25 ENSMUST00000133289.1
solute carrier family 18, subfamily B, member 1
chr16_-_64771146 0.25 ENSMUST00000076991.6
RIKEN cDNA 4930453N24 gene
chr13_-_101692624 0.25 ENSMUST00000035532.6
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr7_-_102714411 0.24 ENSMUST00000084817.2
olfactory receptor 33
chr11_+_62847062 0.24 ENSMUST00000036085.4
F-box and WD-40 domain protein 10
chrX_-_139871637 0.24 ENSMUST00000033811.7
ENSMUST00000087401.5
microrchidia 4
chr2_+_23069210 0.23 ENSMUST00000155602.1
acyl-Coenzyme A binding domain containing 5
chr4_-_14621805 0.23 ENSMUST00000042221.7
solute carrier family 26, member 7
chr1_+_177444653 0.22 ENSMUST00000094276.3
zinc finger and BTB domain containing 18
chr14_+_80000292 0.22 ENSMUST00000088735.3
olfactomedin 4
chrX_-_143933089 0.21 ENSMUST00000087313.3
doublecortin
chr19_+_20601958 0.20 ENSMUST00000087638.3
aldehyde dehydrogenase family 1, subfamily A1
chr1_+_88055377 0.20 ENSMUST00000138182.1
ENSMUST00000113142.3
UDP glycosyltransferase 1 family, polypeptide A10
chrX_+_160768013 0.20 ENSMUST00000033650.7
retinoschisis (X-linked, juvenile) 1 (human)
chr4_+_145514884 0.19 ENSMUST00000105741.1
predicted gene 13225
chr18_+_37477768 0.19 ENSMUST00000051442.5
protocadherin beta 16
chr3_-_20367124 0.19 ENSMUST00000163776.2
ENSMUST00000068316.7
angiotensin II receptor, type 1b
chr7_-_101581161 0.19 ENSMUST00000063920.2
ADP-ribosyltransferase 2b
chr11_-_106314494 0.19 ENSMUST00000167143.1
CD79B antigen
chr11_+_58778089 0.19 ENSMUST00000081533.2
olfactory receptor 315
chr4_+_145510759 0.18 ENSMUST00000105742.1
ENSMUST00000136309.1
predicted gene 13225
chr1_+_88055467 0.18 ENSMUST00000173325.1
UDP glycosyltransferase 1 family, polypeptide A10
chr8_-_106573461 0.18 ENSMUST00000073722.5
predicted pseudogene 10073
chr3_+_41742615 0.17 ENSMUST00000146165.1
ENSMUST00000119572.1
ENSMUST00000108065.2
ENSMUST00000120167.1
ENSMUST00000026867.7
ENSMUST00000026868.7
DNA segment, Chr 3, ERATO Doi 751, expressed
chr10_+_116143881 0.17 ENSMUST00000105271.2
protein tyrosine phosphatase, receptor type, R
chr4_+_138879360 0.17 ENSMUST00000105804.1
phospholipase A2, group IIE
chr10_+_102159000 0.17 ENSMUST00000020039.6
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr4_-_147809788 0.17 ENSMUST00000105734.3
ENSMUST00000176201.1
predicted gene 13157
predicted gene 20707
chr17_-_78684262 0.16 ENSMUST00000145480.1
striatin, calmodulin binding protein
chr19_+_26623419 0.16 ENSMUST00000176584.1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr7_-_37772868 0.16 ENSMUST00000176205.1
zinc finger protein 536
chr5_-_62765618 0.16 ENSMUST00000159470.1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr10_-_62507737 0.15 ENSMUST00000020271.6
serglycin
chr17_-_56036546 0.15 ENSMUST00000003268.9
SH3-domain GRB2-like 1
chr4_+_134930898 0.14 ENSMUST00000030622.2
SYF2 homolog, RNA splicing factor (S. cerevisiae)
chr3_+_142620596 0.14 ENSMUST00000165774.1
guanylate binding protein 2
chr17_+_45734506 0.13 ENSMUST00000180558.1
RIKEN cDNA F630040K05 gene
chr4_+_145670685 0.13 ENSMUST00000105738.2
predicted gene 13242
chr17_-_67950908 0.13 ENSMUST00000164647.1
Rho GTPase activating protein 28
chr9_+_120929216 0.13 ENSMUST00000130466.1
catenin (cadherin associated protein), beta 1
chr1_-_82291370 0.12 ENSMUST00000069799.2
insulin receptor substrate 1
chr15_-_36879816 0.12 ENSMUST00000100713.2
predicted gene 10384
chr3_-_116712644 0.12 ENSMUST00000029569.2
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr16_-_29544852 0.12 ENSMUST00000039090.8
ATPase type 13A4
chr1_+_21240597 0.11 ENSMUST00000121676.1
glutathione S-transferase, alpha 3
chr1_+_153665627 0.11 ENSMUST00000147482.1
regulator of G-protein signaling 8
chr8_-_3624989 0.11 ENSMUST00000142431.1
Purkinje cell protein 2 (L7)
chr2_-_76870486 0.10 ENSMUST00000138542.1
titin
chrX_-_100625901 0.10 ENSMUST00000059099.6
PDZ domain containing 11
chr10_-_64090241 0.10 ENSMUST00000133588.1
leucine rich repeat transmembrane neuronal 3
chr16_+_11406618 0.10 ENSMUST00000122168.1
sorting nexin 29
chr7_+_23983961 0.10 ENSMUST00000077386.4
vomeronasal 1 receptor 181
chr4_+_146502027 0.09 ENSMUST00000105735.2
predicted gene 13247
chr17_-_34862473 0.09 ENSMUST00000025229.4
ENSMUST00000176203.2
ENSMUST00000128767.1
complement factor B
chr6_+_37870786 0.09 ENSMUST00000120428.1
ENSMUST00000031859.7
tripartite motif-containing 24
chr4_+_147492417 0.09 ENSMUST00000105721.2
predicted gene 13152
chr6_-_128275577 0.09 ENSMUST00000130454.1
TEA domain family member 4
chr17_-_34862122 0.08 ENSMUST00000154526.1
complement factor B
chr10_+_116966274 0.08 ENSMUST00000033651.3
RIKEN cDNA D630029K05 gene
chr3_-_14778452 0.08 ENSMUST00000094365.4
carbonic anhydrase 1
chr10_+_116964707 0.08 ENSMUST00000176050.1
ENSMUST00000176455.1
RIKEN cDNA D630029K05 gene
chr10_-_6980376 0.07 ENSMUST00000105617.1
interaction protein for cytohesin exchange factors 1
chr2_+_82053222 0.07 ENSMUST00000047527.7
zinc finger protein 804A
chr3_+_135348029 0.07 ENSMUST00000159658.1
ENSMUST00000078568.5
ENSMUST00000160460.1
solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1
chr2_+_110597298 0.07 ENSMUST00000045972.6
ENSMUST00000111026.2
solute carrier family 5 (sodium/glucose cotransporter), member 12
chr5_-_142530041 0.06 ENSMUST00000099400.2
poly (A) polymerase beta (testis specific)
chr3_-_67515487 0.06 ENSMUST00000178314.1
ENSMUST00000054825.4
retinoic acid receptor responder (tazarotene induced) 1
chr1_+_153665587 0.06 ENSMUST00000147700.1
regulator of G-protein signaling 8
chr3_-_41742471 0.06 ENSMUST00000026866.8
sodium channel and clathrin linker 1
chr5_-_118244861 0.05 ENSMUST00000117177.1
ENSMUST00000133372.1
ENSMUST00000154786.1
ENSMUST00000121369.1
ring finger protein, transmembrane 2
chr11_+_76902152 0.05 ENSMUST00000102495.1
transmembrane and immunoglobulin domain containing 1
chr10_+_75037291 0.05 ENSMUST00000139384.1
RAB36, member RAS oncogene family
chr4_+_118961578 0.05 ENSMUST00000058651.4
L-amino acid oxidase 1
chr1_+_21240581 0.05 ENSMUST00000027067.8
glutathione S-transferase, alpha 3
chr12_-_84617326 0.04 ENSMUST00000021666.4
ATP-binding cassette, sub-family D (ALD), member 4
chr2_+_92185467 0.04 ENSMUST00000111291.2
PHD finger protein 21A
chr4_+_146097312 0.04 ENSMUST00000105730.1
ENSMUST00000091878.5
predicted gene 13051
chr7_-_126976092 0.03 ENSMUST00000181859.1
RIKEN cDNA D830044I16 gene
chr10_+_36506814 0.03 ENSMUST00000167191.1
ENSMUST00000058738.4
heparan sulfate (glucosamine) 3-O-sulfotransferase 5
chr16_+_45224315 0.03 ENSMUST00000102802.3
ENSMUST00000063654.4
B and T lymphocyte associated
chr10_+_5593718 0.03 ENSMUST00000051809.8
myc target 1
chr11_+_6560183 0.03 ENSMUST00000109722.2
cerebral cavernous malformation 2
chr6_-_66559708 0.02 ENSMUST00000079584.1
vomeronasal 1 receptor 32
chr5_-_62766153 0.01 ENSMUST00000076623.4
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr10_-_130394241 0.00 ENSMUST00000094502.4
vomeronasal 2, receptor 84

Network of associatons between targets according to the STRING database.

First level regulatory network of Lhx3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:1904566 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.1 0.4 GO:0002489 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) positive regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000566)
0.1 0.5 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.1 0.5 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.1 0.2 GO:0016062 adaptation of rhodopsin mediated signaling(GO:0016062) light adaption(GO:0036367)
0.1 0.4 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.1 0.3 GO:0002386 immune response in mucosal-associated lymphoid tissue(GO:0002386)
0.1 0.7 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 0.2 GO:1901376 mycotoxin metabolic process(GO:0043385) mycotoxin catabolic process(GO:0043387) aflatoxin metabolic process(GO:0046222) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound metabolic process(GO:1901376) organic heteropentacyclic compound catabolic process(GO:1901377)
0.1 0.2 GO:0033366 protein localization to secretory granule(GO:0033366) protein localization to mast cell secretory granule(GO:0033367) protease localization to mast cell secretory granule(GO:0033368) maintenance of protein location in mast cell secretory granule(GO:0033370) T cell secretory granule organization(GO:0033371) maintenance of protease location in mast cell secretory granule(GO:0033373) protein localization to T cell secretory granule(GO:0033374) protease localization to T cell secretory granule(GO:0033375) maintenance of protein location in T cell secretory granule(GO:0033377) maintenance of protease location in T cell secretory granule(GO:0033379) granzyme B localization to T cell secretory granule(GO:0033380) maintenance of granzyme B location in T cell secretory granule(GO:0033382)
0.0 0.1 GO:0060983 negative regulation of mitotic cell cycle, embryonic(GO:0045976) positive regulation of epithelial cell proliferation involved in prostate gland development(GO:0060769) epicardium-derived cardiac vascular smooth muscle cell differentiation(GO:0060983) canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation(GO:0061324) regulation of histone demethylase activity (H3-K4 specific)(GO:1904173)
0.0 0.2 GO:0019532 oxalate transport(GO:0019532)
0.0 0.6 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.0 0.2 GO:0019364 pyridine nucleotide catabolic process(GO:0019364)
0.0 0.1 GO:0043056 forward locomotion(GO:0043056)
0.0 0.2 GO:0030242 pexophagy(GO:0030242)
0.0 0.1 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.0 0.4 GO:0052696 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.0 0.3 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.0 0.3 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.0 0.2 GO:0042904 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.0 0.2 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.0 0.5 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 0.2 GO:0010459 negative regulation of heart rate(GO:0010459)
0.0 0.1 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.0 0.1 GO:0090273 regulation of somatostatin secretion(GO:0090273)
0.0 0.1 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.0 0.5 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.0 0.2 GO:0002035 brain renin-angiotensin system(GO:0002035)
0.0 0.2 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.0 0.1 GO:0001830 trophectodermal cell fate commitment(GO:0001830)
0.0 0.1 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.0 0.1 GO:0016056 rhodopsin mediated signaling pathway(GO:0016056)
0.0 0.2 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.0 0.2 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.1 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.2 GO:0034374 low-density lipoprotein particle remodeling(GO:0034374)
0.0 0.2 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 0.1 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.4 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.7 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.2 GO:0019815 B cell receptor complex(GO:0019815)
0.0 0.2 GO:0031983 vesicle lumen(GO:0031983)
0.0 0.1 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.0 0.2 GO:0042629 mast cell granule(GO:0042629)
0.0 0.1 GO:0034750 Scrib-APC-beta-catenin complex(GO:0034750)
0.0 0.3 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.2 GO:0042581 specific granule(GO:0042581)
0.0 0.1 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.1 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
0.0 0.3 GO:0002080 acrosomal membrane(GO:0002080)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.1 0.2 GO:0004945 angiotensin type II receptor activity(GO:0004945)
0.1 0.2 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.1 0.4 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.1 0.4 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.4 GO:1901611 phosphatidylglycerol binding(GO:1901611)
0.0 0.8 GO:0042288 MHC class I protein binding(GO:0042288)
0.0 0.3 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 0.3 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 0.3 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 0.5 GO:0044548 S100 protein binding(GO:0044548)
0.0 0.2 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 0.7 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.1 GO:0031433 telethonin binding(GO:0031433)
0.0 0.0 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.0 0.4 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.2 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.3 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.2 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.0 0.1 GO:0034056 estrogen response element binding(GO:0034056)
0.0 0.1 GO:0004064 arylesterase activity(GO:0004064)
0.0 0.8 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.2 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.4 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.1 GO:0015129 lactate transmembrane transporter activity(GO:0015129)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.4 PID NECTIN PATHWAY Nectin adhesion pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 0.5 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 0.4 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.6 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.2 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.2 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade