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12D miR HR13_24

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Results for Thrb

Z-value: 0.38

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Transcription factors associated with Thrb

Gene Symbol Gene ID Gene Info
ENSMUSG00000021779.10 thyroid hormone receptor beta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Thrbmm10_v2_chr14_+_17981633_179816440.284.0e-01Click!

Activity profile of Thrb motif

Sorted Z-values of Thrb motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_14863495 1.50 ENSMUST00000029076.4
carbonic anhydrase 3
chr2_+_119167758 0.77 ENSMUST00000057454.3
GTP cyclohydrolase I feedback regulator
chr9_-_107668967 0.56 ENSMUST00000177567.1
solute carrier family 38, member 3
chr2_-_105399286 0.50 ENSMUST00000006128.6
reticulocalbin 1
chr7_-_25005895 0.48 ENSMUST00000102858.3
ENSMUST00000080882.6
ATPase, Na+/K+ transporting, alpha 3 polypeptide
chr16_-_17144415 0.48 ENSMUST00000115709.1
coiled-coil domain containing 116
chr14_+_54476100 0.45 ENSMUST00000164766.1
ENSMUST00000164697.1
rad and gem related GTP binding protein 2
chr5_+_108065696 0.38 ENSMUST00000172045.1
metal response element binding transcription factor 2
chr7_+_101896817 0.35 ENSMUST00000143835.1
anaphase prompoting complex C subunit 15
chr2_+_32363004 0.31 ENSMUST00000132028.1
ENSMUST00000136079.1
CDKN1A interacting zinc finger protein 1
chr2_+_152962485 0.29 ENSMUST00000099197.2
ENSMUST00000103155.3
tubulin tyrosine ligase-like family, member 9
chr1_+_87214286 0.29 ENSMUST00000113231.3
eukaryotic translation initiation factor 4E member 2
chr10_+_81176631 0.27 ENSMUST00000047864.9
eukaryotic translation elongation factor 2
chr3_+_101377074 0.26 ENSMUST00000043983.5
immunoglobulin superfamily, member 3
chr2_+_32363163 0.25 ENSMUST00000145635.1
CDKN1A interacting zinc finger protein 1
chr9_+_95857597 0.24 ENSMUST00000034980.7
ataxia telangiectasia and Rad3 related
chr2_+_32363192 0.21 ENSMUST00000048964.7
ENSMUST00000113332.1
CDKN1A interacting zinc finger protein 1
chr16_+_36934976 0.18 ENSMUST00000023531.8
hematopoietic cell specific Lyn substrate 1
chr17_+_56162477 0.18 ENSMUST00000077788.6
tumor necrosis factor, alpha-induced protein 8-like 1
chr1_+_87213924 0.18 ENSMUST00000113230.1
ENSMUST00000123735.1
eukaryotic translation initiation factor 4E member 2
chr11_+_46404720 0.18 ENSMUST00000063166.5
family with sequence similarity 71, member B
chr14_-_7994563 0.18 ENSMUST00000026315.7
deoxyribonuclease 1-like 3
chr10_+_87521920 0.17 ENSMUST00000142088.1
phenylalanine hydroxylase
chr15_-_100669496 0.16 ENSMUST00000182814.1
ENSMUST00000182068.1
bridging integrator 2
chr11_-_58938851 0.15 ENSMUST00000094151.5
ring finger protein 187
chr16_+_37916440 0.15 ENSMUST00000061274.7
G protein-coupled receptor 156
chr5_+_108065742 0.14 ENSMUST00000081567.4
ENSMUST00000170319.1
ENSMUST00000112626.1
metal response element binding transcription factor 2
chr11_-_58626044 0.14 ENSMUST00000070804.2
olfactory receptor 323
chr3_+_67374091 0.12 ENSMUST00000077916.5
myeloid leukemia factor 1
chr11_+_109485606 0.10 ENSMUST00000106697.1
arylsulfatase G
chrX_+_112311334 0.09 ENSMUST00000026599.3
ENSMUST00000113415.1
apolipoprotein O-like
chr11_+_49203465 0.08 ENSMUST00000150284.1
ENSMUST00000109197.1
ENSMUST00000151228.1
zinc finger protein 62
chr11_-_103344651 0.08 ENSMUST00000041385.7
Rho GTPase activating protein 27
chr13_+_30749226 0.07 ENSMUST00000021784.2
ENSMUST00000110307.1
interferon regulatory factor 4
chr9_+_44673227 0.07 ENSMUST00000034609.4
ENSMUST00000071219.5
trehalase (brush-border membrane glycoprotein)
chr10_+_87521795 0.06 ENSMUST00000020241.8
phenylalanine hydroxylase
chr2_-_25469742 0.05 ENSMUST00000114259.2
ENSMUST00000015234.6
prostaglandin D2 synthase (brain)
chr2_+_92382911 0.05 ENSMUST00000054316.2
ENSMUST00000111280.2
RIKEN cDNA 1700029I15 gene
chr2_-_25470031 0.05 ENSMUST00000114251.1
prostaglandin D2 synthase (brain)
chr8_-_119501695 0.04 ENSMUST00000133821.1
ENSMUST00000036748.8
solute carrier family 38, member 8
chr16_+_32419696 0.04 ENSMUST00000014220.8
ENSMUST00000080316.7
Tctex1 domain containing 2
chr17_+_36943025 0.03 ENSMUST00000173072.1
ring finger protein 39
chr9_-_102626095 0.02 ENSMUST00000093791.3
centrosomal protein 63
chr11_-_113710017 0.01 ENSMUST00000018871.1
cleavage and polyadenylation specific factor 4-like
chr6_+_83237375 0.01 ENSMUST00000039212.7
ENSMUST00000113899.1
solute carrier family 4, sodium bicarbonate cotransporter, member 5
chr9_+_102626278 0.01 ENSMUST00000038673.7
anaphase promoting complex subunit 13
chr9_-_102626509 0.00 ENSMUST00000161645.1
ENSMUST00000162297.1
ENSMUST00000162655.1
centrosomal protein 63
chr4_-_148444744 0.00 ENSMUST00000051633.2
UbiA prenyltransferase domain containing 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Thrb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0061402 positive regulation of transcription from RNA polymerase II promoter in response to acidic pH(GO:0061402)
0.2 0.8 GO:0032298 positive regulation of DNA-dependent DNA replication initiation(GO:0032298)
0.1 0.5 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.1 0.5 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.1 0.2 GO:1904884 telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
0.1 0.2 GO:0009095 tyrosine biosynthetic process(GO:0006571) aromatic amino acid family biosynthetic process(GO:0009073) aromatic amino acid family biosynthetic process, prephenate pathway(GO:0009095)
0.0 0.5 GO:0036376 sodium ion export from cell(GO:0036376)
0.0 0.3 GO:2000767 positive regulation of cytoplasmic translation(GO:2000767)
0.0 1.5 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 0.1 GO:0042231 interleukin-10 biosynthetic process(GO:0042091) interleukin-13 biosynthetic process(GO:0042231) regulation of interleukin-10 biosynthetic process(GO:0045074) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.0 0.3 GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.1 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.0 0.1 GO:0005984 disaccharide metabolic process(GO:0005984)
0.0 0.3 GO:0032808 lacrimal gland development(GO:0032808)
0.0 0.1 GO:0002318 myeloid progenitor cell differentiation(GO:0002318)
0.0 0.2 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.5 GO:0005845 mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0 0.8 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.5 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.3 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.4 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.1 GO:0061617 MICOS complex(GO:0061617)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0015182 L-asparagine transmembrane transporter activity(GO:0015182)
0.1 1.5 GO:0016151 nickel cation binding(GO:0016151)
0.0 0.5 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556)
0.0 0.2 GO:0004505 phenylalanine 4-monooxygenase activity(GO:0004505)
0.0 0.2 GO:0032405 MutLalpha complex binding(GO:0032405) MutSalpha complex binding(GO:0032407)
0.0 0.1 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.1 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.0 0.8 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.0 0.3 GO:0008097 5S rRNA binding(GO:0008097)
0.0 0.8 GO:0030332 cyclin binding(GO:0030332)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 PID CIRCADIAN PATHWAY Circadian rhythm pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.2 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.1 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.6 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.1 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.5 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases