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12D miR HR13_24

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Results for Hoxd10

Z-value: 0.48

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Transcription factors associated with Hoxd10

Gene Symbol Gene ID Gene Info
ENSMUSG00000050368.3 homeobox D10

Activity profile of Hoxd10 motif

Sorted Z-values of Hoxd10 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr13_-_71963713 1.32 ENSMUST00000077337.8
Iroquois related homeobox 1 (Drosophila)
chr3_+_138277489 1.10 ENSMUST00000004232.9
alcohol dehydrogenase 1 (class I)
chr3_+_106486009 0.78 ENSMUST00000183271.1
ENSMUST00000061206.3
DENN/MADD domain containing 2D
chr2_+_21367532 0.76 ENSMUST00000055946.7
G protein-coupled receptor 158
chr4_+_102254993 0.74 ENSMUST00000106908.2
phosphodiesterase 4B, cAMP specific
chr19_+_37436707 0.66 ENSMUST00000128184.1
hematopoietically expressed homeobox
chr4_+_100478806 0.63 ENSMUST00000133493.2
ENSMUST00000092730.3
ENSMUST00000106979.3
ubiquitin-conjugating enzyme E2U (putative)
chr9_+_104569671 0.59 ENSMUST00000057742.8
copine IV
chr14_+_103513328 0.58 ENSMUST00000095576.3
sciellin
chr3_+_115080965 0.57 ENSMUST00000051309.8
olfactomedin 3
chr7_+_51880312 0.50 ENSMUST00000145049.1
growth arrest specific 2
chr11_-_99244058 0.49 ENSMUST00000103132.3
ENSMUST00000038214.6
keratin 222
chr15_+_25773985 0.48 ENSMUST00000125667.1
myosin X
chr6_+_97807014 0.47 ENSMUST00000043637.7
microphthalmia-associated transcription factor
chr8_+_109990430 0.45 ENSMUST00000001720.7
ENSMUST00000143741.1
tyrosine aminotransferase
chr5_+_20702129 0.41 ENSMUST00000101556.4
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr17_-_78684262 0.35 ENSMUST00000145480.1
striatin, calmodulin binding protein
chr10_+_116177351 0.34 ENSMUST00000155606.1
ENSMUST00000128399.1
protein tyrosine phosphatase, receptor type, R
chr3_-_75270073 0.30 ENSMUST00000039047.4
serine (or cysteine) peptidase inhibitor, clade I, member 2
chr13_+_40917626 0.28 ENSMUST00000067778.6
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr1_+_150100093 0.28 ENSMUST00000035065.7
prostaglandin-endoperoxide synthase 2
chr2_+_106693185 0.27 ENSMUST00000111063.1
metallophosphoesterase domain containing 2
chr14_+_79515618 0.23 ENSMUST00000110835.1
E74-like factor 1
chr4_+_19605451 0.19 ENSMUST00000108250.2
predicted gene 12353
chr7_+_30095150 0.19 ENSMUST00000130526.1
ENSMUST00000108200.1
zinc finger protein 260
chrX_-_70365052 0.18 ENSMUST00000101509.2
iduronate 2-sulfatase
chr12_+_55089202 0.18 ENSMUST00000021407.10
signal recognition particle 54A
chr18_-_6490808 0.17 ENSMUST00000028100.6
ENSMUST00000050542.5
enhancer of polycomb homolog 1 (Drosophila)
chr13_-_12520377 0.16 ENSMUST00000179308.1
EDAR (ectodysplasin-A receptor)-associated death domain
chr10_-_24101951 0.14 ENSMUST00000170267.1
trace amine-associated receptor 8C
chrX_-_9469288 0.13 ENSMUST00000015484.3
cytochrome b-245, beta polypeptide
chr14_-_93888732 0.13 ENSMUST00000068992.2
protocadherin 9
chr9_-_45828618 0.12 ENSMUST00000117194.1
centrosomal protein 164
chr1_+_107422681 0.11 ENSMUST00000112710.1
ENSMUST00000086690.4
serine (or cysteine) peptidase inhibitor, clade B, member 7
chr16_-_23029080 0.10 ENSMUST00000100046.2
kininogen 2
chr6_-_92481343 0.10 ENSMUST00000113445.1
prickle homolog 2 (Drosophila)
chr2_+_120404757 0.06 ENSMUST00000135074.1
glucosidase, alpha; neutral C
chr4_-_108833544 0.06 ENSMUST00000102740.1
ENSMUST00000102741.1
basic transcription factor 3-like 4
chr4_-_36136463 0.06 ENSMUST00000098151.2
leucine rich repeat and Ig domain containing 2
chr3_-_95282076 0.06 ENSMUST00000015855.7
prune homolog (Drosophila)
chr10_+_128790903 0.06 ENSMUST00000026411.6
matrix metallopeptidase 19
chr11_-_58552237 0.05 ENSMUST00000073933.1
olfactory receptor 328
chr19_+_34100943 0.05 ENSMUST00000025685.6
lipase, family member M
chr7_-_84679346 0.04 ENSMUST00000069537.2
ENSMUST00000178385.1
zinc finger, AN1-type domain 6
chr7_+_43690418 0.04 ENSMUST00000056329.6
kallikrein related-peptidase 14
chr1_+_180111339 0.04 ENSMUST00000145181.1
CDC42 binding protein kinase alpha
chr16_+_25801907 0.03 ENSMUST00000040231.6
ENSMUST00000115306.1
ENSMUST00000115304.1
ENSMUST00000115305.1
transformation related protein 63
chr15_-_5108469 0.02 ENSMUST00000141020.1
caspase recruitment domain family, member 6
chr17_-_46327949 0.02 ENSMUST00000047970.7
ATP-binding cassette, sub-family C (CFTR/MRP), member 10
chr6_-_28397999 0.02 ENSMUST00000035930.4
zinc finger protein 800
chr13_-_21556020 0.02 ENSMUST00000068163.1
olfactory receptor 1535
chr11_+_58786139 0.01 ENSMUST00000076393.3
olfactory receptor 314

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxd10

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0072272 proximal/distal pattern formation involved in metanephric nephron development(GO:0072272)
0.3 1.1 GO:0006069 ethanol oxidation(GO:0006069)
0.2 0.7 GO:0061010 gall bladder development(GO:0061010)
0.1 0.4 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.1 0.4 GO:0006572 tyrosine catabolic process(GO:0006572)
0.1 0.7 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 0.3 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.0 0.3 GO:0036438 maintenance of lens transparency(GO:0036438)
0.0 0.4 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.0 0.2 GO:0061152 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.0 0.5 GO:0044336 canonical Wnt signaling pathway involved in negative regulation of apoptotic process(GO:0044336)
0.0 0.1 GO:0001830 trophectodermal cell fate commitment(GO:0001830)
0.0 0.1 GO:0097411 hypoxia-inducible factor-1alpha signaling pathway(GO:0097411)
0.0 0.2 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 0.2 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.6 GO:0042462 eye photoreceptor cell development(GO:0042462)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0033503 HULC complex(GO:0033503)
0.0 0.2 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.7 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.4 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.2 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.0 0.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.1 GO:0043020 NADPH oxidase complex(GO:0043020)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.1 0.4 GO:0070546 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.1 0.3 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.1 0.4 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 0.7 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190) DNA binding, bending(GO:0008301)
0.0 0.2 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.0 0.7 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.1 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.0 0.4 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.1 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 0.8 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.1 GO:0032450 maltose alpha-glucosidase activity(GO:0032450)
0.0 0.2 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.0 0.3 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID NETRIN PATHWAY Netrin-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.7 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.2 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.4 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions