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12D miR HR13_24

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Results for Trp73

Z-value: 0.52

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Transcription factors associated with Trp73

Gene Symbol Gene ID Gene Info
ENSMUSG00000029026.10 transformation related protein 73

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Trp73mm10_v2_chr4_-_154097105_154097173-0.166.3e-01Click!

Activity profile of Trp73 motif

Sorted Z-values of Trp73 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_106804998 0.68 ENSMUST00000065253.6
acyl-CoA thioesterase 11
chr17_+_29090969 0.66 ENSMUST00000119901.1
cyclin-dependent kinase inhibitor 1A (P21)
chr4_-_11386679 0.50 ENSMUST00000043781.7
ENSMUST00000108310.1
epithelial splicing regulatory protein 1
chr4_-_11386757 0.50 ENSMUST00000108313.1
ENSMUST00000108311.2
epithelial splicing regulatory protein 1
chr7_-_31054815 0.39 ENSMUST00000071697.4
ENSMUST00000108110.3
FXYD domain-containing ion transport regulator 1
chrX_+_103321398 0.37 ENSMUST00000033689.2
caudal type homeobox 4
chr11_+_114851142 0.36 ENSMUST00000133245.1
ENSMUST00000122967.2
G protein-coupled receptor, family C, group 5, member C
chr14_-_24245913 0.34 ENSMUST00000073687.6
ENSMUST00000090398.4
discs, large homolog 5 (Drosophila)
chr8_+_122269569 0.30 ENSMUST00000055537.2
predicted gene 22
chr5_-_103629279 0.26 ENSMUST00000031263.1
solute carrier family 10 (sodium/bile acid cotransporter family), member 6
chr1_+_170214826 0.25 ENSMUST00000159201.1
ENSMUST00000055830.1
RIKEN cDNA 4930500M09 gene
chr7_-_141443314 0.24 ENSMUST00000106005.2
leucine-rich and death domain containing
chr4_-_115781012 0.23 ENSMUST00000106521.1
testis expressed 38
chr2_-_164857671 0.22 ENSMUST00000059954.7
phospholipid transfer protein
chr3_+_159839729 0.22 ENSMUST00000068952.5
wntless homolog (Drosophila)
chr7_-_116038734 0.22 ENSMUST00000166877.1
SRY-box containing gene 6
chr2_+_119237531 0.22 ENSMUST00000110817.2
serine protease inhibitor, Kunitz type 1
chr2_+_34772089 0.20 ENSMUST00000028222.6
ENSMUST00000100171.2
heat shock protein 5
chr2_+_119237351 0.20 ENSMUST00000028783.7
serine protease inhibitor, Kunitz type 1
chr2_-_164857542 0.20 ENSMUST00000109316.1
ENSMUST00000156255.1
ENSMUST00000128110.1
ENSMUST00000109317.3
phospholipid transfer protein
chr1_+_153665274 0.19 ENSMUST00000152114.1
ENSMUST00000111812.1
regulator of G-protein signaling 8
chr19_-_34747289 0.19 ENSMUST00000009522.3
solute carrier family 16 (monocarboxylic acid transporters), member 12
chr10_+_52391606 0.19 ENSMUST00000067085.4
nephrocan
chr2_+_119237453 0.19 ENSMUST00000110816.1
serine protease inhibitor, Kunitz type 1
chr1_-_5070281 0.17 ENSMUST00000147158.1
ENSMUST00000118000.1
regulator of G-protein signaling 20
chr5_-_139819906 0.17 ENSMUST00000147328.1
transmembrane protein 184a
chr11_+_114851507 0.17 ENSMUST00000177952.1
G protein-coupled receptor, family C, group 5, member C
chr13_-_55021287 0.17 ENSMUST00000148221.1
ENSMUST00000052949.6
hexokinase 3
chr18_+_56432116 0.17 ENSMUST00000070166.5
GRAM domain containing 3
chr9_+_108986163 0.17 ENSMUST00000052724.3
urocortin 2
chr15_-_7398334 0.16 ENSMUST00000096494.4
EGF-like, fibronectin type III and laminin G domains
chr5_+_137288273 0.16 ENSMUST00000024099.4
ENSMUST00000085934.3
acetylcholinesterase
chr6_+_29398920 0.15 ENSMUST00000181464.1
ENSMUST00000180829.1
coiled-coil domain containing 136
chr15_-_7398233 0.15 ENSMUST00000058593.3
EGF-like, fibronectin type III and laminin G domains
chr8_-_70659645 0.15 ENSMUST00000070173.7
pyroglutamyl-peptidase I
chr19_-_7105729 0.15 ENSMUST00000113383.2
fibronectin leucine rich transmembrane protein 1
chr14_+_34085978 0.13 ENSMUST00000022519.8
annexin A8
chrX_-_10216918 0.13 ENSMUST00000072393.2
ENSMUST00000044598.6
ENSMUST00000073392.4
ENSMUST00000115533.1
ENSMUST00000115532.1
retinitis pigmentosa GTPase regulator
chr8_-_85067982 0.12 ENSMUST00000177563.1
predicted gene 5741
chr2_+_118779703 0.12 ENSMUST00000063975.3
ENSMUST00000037547.2
ENSMUST00000110846.1
ENSMUST00000110843.1
dispatched homolog 2 (Drosophila)
chr10_-_62651194 0.12 ENSMUST00000020270.4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
chr5_-_36748639 0.12 ENSMUST00000071949.3
biogenesis of organelles complex-1, subunit 4, cappuccino
chr18_+_51117754 0.12 ENSMUST00000116639.2
proline rich 16
chr5_-_30960326 0.12 ENSMUST00000074840.5
prolactin regulatory element binding
chr5_-_30960236 0.11 ENSMUST00000088063.2
prolactin regulatory element binding
chr5_+_43233928 0.11 ENSMUST00000114066.1
ENSMUST00000114065.1
cytoplasmic polyadenylation element binding protein 2
chr3_-_107931579 0.11 ENSMUST00000133947.2
ENSMUST00000124215.1
ENSMUST00000106688.1
ENSMUST00000106687.2
glutathione S-transferase, mu 7
chr13_-_55021196 0.10 ENSMUST00000153665.1
hexokinase 3
chr9_-_64341145 0.10 ENSMUST00000120760.1
ENSMUST00000168844.2
DIS3 mitotic control homolog (S. cerevisiae)-like
chr12_+_109747903 0.09 ENSMUST00000183084.1
ENSMUST00000182300.1
miRNA containing gene
chr15_+_30172570 0.09 ENSMUST00000081728.5
catenin (cadherin associated protein), delta 2
chr11_-_103344651 0.09 ENSMUST00000041385.7
Rho GTPase activating protein 27
chr12_+_3365108 0.08 ENSMUST00000020999.5
kinesin family member 3C
chr3_+_89245952 0.08 ENSMUST00000040888.5
keratinocyte associated protein 2
chr11_+_60931998 0.08 ENSMUST00000019076.3
mitogen-activated protein kinase kinase 3
chr1_-_39478734 0.08 ENSMUST00000054462.5
TBC1 domain family, member 8
chr15_+_84232030 0.07 ENSMUST00000023072.6
parvin, beta
chr3_-_89245829 0.07 ENSMUST00000041022.8
tripartite motif-containing 46
chr4_+_109000606 0.07 ENSMUST00000065977.4
ENSMUST00000102736.2
nardilysin, N-arginine dibasic convertase, NRD convertase 1
chr10_-_127311740 0.07 ENSMUST00000037290.5
ENSMUST00000171564.1
methionine-tRNA synthetase
chr10_+_39369750 0.07 ENSMUST00000063091.6
ENSMUST00000099967.3
ENSMUST00000126486.1
Fyn proto-oncogene
chr11_-_33578933 0.07 ENSMUST00000020366.1
ENSMUST00000135350.1
gamma-aminobutyric acid (GABA) A receptor, pi
chr10_-_105841323 0.07 ENSMUST00000046638.9
methyltransferase like 25
chr10_-_57532416 0.07 ENSMUST00000169122.1
serine incorporator 1
chr19_-_47157764 0.07 ENSMUST00000178630.1
calcium homeostasis modulator 3
chr4_+_119232896 0.06 ENSMUST00000121111.2
ENSMUST00000030393.6
ENSMUST00000102662.4
leprecan 1
chr17_+_28232723 0.06 ENSMUST00000002320.8
peroxisome proliferator activator receptor delta
chr9_-_58158498 0.06 ENSMUST00000168864.2
immunoglobulin superfamily containing leucine-rich repeat
chr4_-_45489794 0.06 ENSMUST00000146236.1
src homology 2 domain-containing transforming protein B
chr10_-_57532489 0.05 ENSMUST00000020027.4
serine incorporator 1
chr11_+_4267095 0.05 ENSMUST00000040750.3
leukemia inhibitory factor
chr7_-_5014645 0.05 ENSMUST00000165320.1
Flt3 interacting zinc finger protein 1
chr2_-_127541385 0.05 ENSMUST00000103214.2
prominin 2
chr3_-_89402650 0.05 ENSMUST00000168325.1
ENSMUST00000057431.5
lens epithelial protein
chr7_+_25282179 0.05 ENSMUST00000163320.1
ENSMUST00000005578.6
capicua homolog (Drosophila)
chr7_-_65371210 0.04 ENSMUST00000102592.3
tight junction protein 1
chr5_-_33782810 0.04 ENSMUST00000005431.5
leucine zipper-EF-hand containing transmembrane protein 1
chr14_+_34086008 0.04 ENSMUST00000120077.1
annexin A8
chrX_+_10717451 0.04 ENSMUST00000156321.1
Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish))
chr3_+_108085976 0.04 ENSMUST00000070502.1
predicted gene 12500
chr11_+_57801575 0.04 ENSMUST00000020826.5
SAP30-like
chr13_+_48261427 0.04 ENSMUST00000021810.1
inhibitor of DNA binding 4
chr12_-_84876479 0.04 ENSMUST00000163189.1
ENSMUST00000110254.2
ENSMUST00000002073.6
latent transforming growth factor beta binding protein 2
chr9_-_65885024 0.04 ENSMUST00000122410.1
ENSMUST00000117083.1
thyroid hormone receptor interactor 4
chr16_-_18629864 0.04 ENSMUST00000096987.5
septin 5
chr14_-_73325773 0.03 ENSMUST00000022701.6
retinoblastoma 1
chr19_+_46304709 0.03 ENSMUST00000073116.5
nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
chr5_-_92083667 0.03 ENSMUST00000113127.3
GTPase activating protein (SH3 domain) binding protein 2
chr5_-_92083455 0.03 ENSMUST00000169094.1
ENSMUST00000167918.1
GTPase activating protein (SH3 domain) binding protein 2
chr1_-_170215380 0.03 ENSMUST00000027979.7
ENSMUST00000123399.1
U2AF homology motif (UHM) kinase 1
chr1_+_55088132 0.03 ENSMUST00000075242.6
heat shock protein 1 (chaperonin 10)
chr12_-_45074457 0.02 ENSMUST00000053768.6
syntaxin binding protein 6 (amisyn)
chr10_+_127642975 0.02 ENSMUST00000092074.5
ENSMUST00000120279.1
signal transducer and activator of transcription 6
chr11_+_69913888 0.02 ENSMUST00000072581.2
ENSMUST00000116358.1
G protein pathway suppressor 2
chr11_-_76468396 0.02 ENSMUST00000065028.7
active BCR-related gene
chr8_+_27085520 0.02 ENSMUST00000178514.1
ENSMUST00000033876.7
G protein-coupled receptor 124
chr11_-_20831009 0.01 ENSMUST00000047028.8
lectin, galactoside binding-like
chr4_+_74251928 0.01 ENSMUST00000030102.5
lysine (K)-specific demethylase 4C
chr1_+_135729147 0.01 ENSMUST00000027677.7
cysteine and glycine-rich protein 1
chr4_-_87806276 0.01 ENSMUST00000148059.1
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr8_+_27085835 0.01 ENSMUST00000165366.2
G protein-coupled receptor 124
chr15_-_98607611 0.00 ENSMUST00000096224.4
adenylate cyclase 6

Network of associatons between targets according to the STRING database.

First level regulatory network of Trp73

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0042360 vitamin E metabolic process(GO:0042360)
0.1 0.2 GO:0048209 regulation of vesicle targeting, to, from or within Golgi(GO:0048209)
0.1 0.2 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.1 0.2 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.1 0.7 GO:0071493 cellular response to UV-B(GO:0071493)
0.1 0.4 GO:1903278 positive regulation of sodium ion export(GO:1903275) positive regulation of sodium ion export from cell(GO:1903278)
0.1 0.2 GO:0015881 creatine transport(GO:0015881)
0.0 0.3 GO:0072205 negative regulation of hippo signaling(GO:0035331) protein localization to adherens junction(GO:0071896) metanephric collecting duct development(GO:0072205)
0.0 0.2 GO:0033685 negative regulation of luteinizing hormone secretion(GO:0033685)
0.0 0.2 GO:1900619 acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)
0.0 0.6 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.0 0.2 GO:0018992 germ-line sex determination(GO:0018992)
0.0 0.3 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.3 GO:1901299 negative regulation of hydrogen peroxide-mediated programmed cell death(GO:1901299)
0.0 1.0 GO:0060445 branching involved in salivary gland morphogenesis(GO:0060445)
0.0 0.1 GO:0071963 establishment or maintenance of cell polarity regulating cell shape(GO:0071963)
0.0 0.1 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.0 0.2 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0 0.1 GO:0072108 positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis(GO:0072108)
0.0 0.1 GO:1904217 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.0 0.2 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.1 GO:0045900 negative regulation of translational elongation(GO:0045900)
0.0 0.1 GO:1902951 negative regulation of dendritic spine maintenance(GO:1902951)
0.0 0.7 GO:0009409 response to cold(GO:0009409)
0.0 0.0 GO:0034085 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0 0.0 GO:0002268 follicular dendritic cell activation(GO:0002266) follicular dendritic cell differentiation(GO:0002268)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0070557 PCNA-p21 complex(GO:0070557)
0.0 0.5 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.2 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.2 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.0 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.2 0.5 GO:0005118 sevenless binding(GO:0005118)
0.1 0.2 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429)
0.1 0.2 GO:0005308 creatine transmembrane transporter activity(GO:0005308)
0.0 0.2 GO:0004104 cholinesterase activity(GO:0004104)
0.0 0.3 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.2 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.0 0.6 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.0 0.1 GO:0016501 prostacyclin receptor activity(GO:0016501)
0.0 0.1 GO:0042610 CD8 receptor binding(GO:0042610)
0.0 0.1 GO:0005146 leukemia inhibitory factor receptor binding(GO:0005146)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 0.2 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.3 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.4 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport