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12D miR HR13_24

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Results for Rfx5

Z-value: 0.42

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Transcription factors associated with Rfx5

Gene Symbol Gene ID Gene Info
ENSMUSG00000005774.6 regulatory factor X, 5 (influences HLA class II expression)

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Rfx5mm10_v2_chr3_+_94954075_949542260.511.1e-01Click!

Activity profile of Rfx5 motif

Sorted Z-values of Rfx5 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_117523526 0.48 ENSMUST00000132261.1
predicted gene 11734
chr17_+_34325658 0.42 ENSMUST00000050325.8
histocompatibility 2, class II antigen E beta2
chr11_+_106276715 0.37 ENSMUST00000044462.3
testicular cell adhesion molecule 1
chr14_+_55618023 0.35 ENSMUST00000002395.7
REC8 homolog (yeast)
chr6_-_29165003 0.24 ENSMUST00000007993.9
RNA binding motif protein 28
chr17_+_34135182 0.22 ENSMUST00000042121.9
histocompatibility 2, class II, locus DMa
chr9_-_51102062 0.22 ENSMUST00000170947.1
RIKEN cDNA 4833427G06 gene
chr17_+_34238896 0.22 ENSMUST00000095342.3
histocompatibility 2, O region beta locus
chr17_+_34153072 0.21 ENSMUST00000114232.2
histocompatibility 2, class II, locus Mb1
chr17_+_34187545 0.21 ENSMUST00000170086.1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr17_-_34305715 0.20 ENSMUST00000174074.1
predicted gene 20513
chr17_+_34187789 0.19 ENSMUST00000041633.8
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr5_+_139150211 0.18 ENSMUST00000026975.6
HEAT repeat containing 2
chr7_-_101921186 0.17 ENSMUST00000106965.1
ENSMUST00000106968.1
ENSMUST00000106967.1
leucine rich repeat containing 51
chr19_-_10482874 0.16 ENSMUST00000038842.3
protein phosphatase 1, regulatory subunit 32
chr6_-_8259098 0.15 ENSMUST00000012627.4
replication protein A3
chr19_+_37376359 0.15 ENSMUST00000012587.3
kinesin family member 11
chr7_-_101921175 0.15 ENSMUST00000098236.2
leucine rich repeat containing 51
chr18_+_60803838 0.15 ENSMUST00000050487.8
ENSMUST00000097563.2
ENSMUST00000167610.1
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
chr5_-_125294107 0.14 ENSMUST00000127148.1
scavenger receptor class B, member 1
chr14_+_53649387 0.14 ENSMUST00000103660.2
T cell receptor alpha variable 15-2-DV6-2
chr8_-_85067982 0.13 ENSMUST00000177563.1
predicted gene 5741
chr9_+_44773191 0.13 ENSMUST00000147559.1
intraflagellar transport 46
chr2_-_28563362 0.13 ENSMUST00000028161.5
carboxyl ester lipase
chr7_+_28179469 0.13 ENSMUST00000085901.6
ENSMUST00000172761.1
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b
chr7_+_28180272 0.13 ENSMUST00000173223.1
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b
chr3_-_95882031 0.12 ENSMUST00000161994.1
predicted gene 129
chr17_+_34263209 0.12 ENSMUST00000040828.5
histocompatibility 2, class II antigen A, beta 1
chr7_+_101378183 0.11 ENSMUST00000084895.5
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr17_+_35861318 0.11 ENSMUST00000074259.8
ENSMUST00000174873.1
nurim (nuclear envelope membrane protein)
chr7_-_105752193 0.11 ENSMUST00000033184.4
tripeptidyl peptidase I
chr7_-_45694369 0.10 ENSMUST00000040636.6
secretory blood group 1
chr10_-_127263346 0.10 ENSMUST00000099172.3
kinesin family member 5A
chr2_+_163438455 0.10 ENSMUST00000109420.3
ENSMUST00000109421.3
ENSMUST00000018087.6
ENSMUST00000137070.1
ganglioside-induced differentiation-associated protein 1-like 1
chr7_+_28180226 0.10 ENSMUST00000172467.1
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b
chr1_+_134405984 0.10 ENSMUST00000173908.1
cytochrome b5 reductase 1
chr9_+_21196705 0.10 ENSMUST00000003395.9
phosphodiesterase 4A, cAMP specific
chr2_-_152398046 0.09 ENSMUST00000063332.8
ENSMUST00000182625.1
SRY-box containing gene 12
chr10_-_123196916 0.09 ENSMUST00000020334.7
ubiquitin specific peptidase 15
chr12_-_87102350 0.09 ENSMUST00000110176.1
neuroglobin
chr8_-_104509874 0.09 ENSMUST00000064576.1
ENSMUST00000162014.1
coiled-coil domain containing 79
chr2_-_92434027 0.08 ENSMUST00000111278.1
ENSMUST00000090559.5
cryptochrome 2 (photolyase-like)
chr17_+_34238914 0.08 ENSMUST00000167280.1
histocompatibility 2, O region beta locus
chr17_+_34145311 0.07 ENSMUST00000041982.7
histocompatibility 2, class II, locus Mb2
chr17_+_35439155 0.07 ENSMUST00000071951.6
ENSMUST00000078205.7
ENSMUST00000116598.3
ENSMUST00000076256.7
histocompatibility 2, Q region locus 7
chr17_+_34145231 0.06 ENSMUST00000171231.1
histocompatibility 2, class II, locus Mb2
chr16_+_20696175 0.06 ENSMUST00000128273.1
family with sequence similarity 131, member A
chr7_+_44467980 0.06 ENSMUST00000035844.4
Josephin domain containing 2
chr3_-_95882232 0.05 ENSMUST00000161866.1
predicted gene 129
chr11_+_72441341 0.05 ENSMUST00000045633.5
MYB binding protein (P160) 1a
chr8_+_27042555 0.05 ENSMUST00000033875.8
ENSMUST00000098851.4
proline synthetase co-transcribed
chr1_-_183147461 0.05 ENSMUST00000171366.1
dispatched homolog 1 (Drosophila)
chr17_+_34305883 0.04 ENSMUST00000074557.8
histocompatibility 2, class II antigen E beta
chr4_+_66827545 0.04 ENSMUST00000048096.5
ENSMUST00000107365.2
toll-like receptor 4
chr7_+_44468020 0.04 ENSMUST00000117324.1
ENSMUST00000120852.1
ENSMUST00000118628.1
Josephin domain containing 2
chr1_+_136676413 0.04 ENSMUST00000181491.1
predicted gene, 19705
chr8_+_84969587 0.04 ENSMUST00000109734.1
ENSMUST00000005292.8
peroxiredoxin 2
chr11_-_3539228 0.04 ENSMUST00000075118.3
ENSMUST00000136243.1
ENSMUST00000170588.1
ENSMUST00000020721.8
smoothelin
chr7_+_44468051 0.04 ENSMUST00000118493.1
Josephin domain containing 2
chr2_+_69380431 0.03 ENSMUST00000063690.3
dehydrogenase/reductase (SDR family) member 9
chr13_+_24831661 0.02 ENSMUST00000038039.2
tyrosyl-DNA phosphodiesterase 2
chr8_+_81856324 0.02 ENSMUST00000109851.2
inositol polyphosphate-4-phosphatase, type II
chr9_+_44773027 0.02 ENSMUST00000125877.1
intraflagellar transport 46
chrX_-_160138375 0.01 ENSMUST00000033662.8
pyruvate dehydrogenase E1 alpha 1
chr7_+_127091426 0.01 ENSMUST00000056288.5
expressed sequence AI467606
chr9_+_44772951 0.01 ENSMUST00000128150.1
intraflagellar transport 46
chr6_+_94500313 0.01 ENSMUST00000061118.8
solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26
chr2_+_122147680 0.01 ENSMUST00000102476.4
beta-2 microglobulin
chr3_+_16183177 0.01 ENSMUST00000108345.2
ENSMUST00000108346.2
YTH domain family 3
chr17_-_24886304 0.01 ENSMUST00000044252.5
nucleotide binding protein 2
chr3_-_95882193 0.01 ENSMUST00000159863.1
ENSMUST00000159739.1
ENSMUST00000036418.3
predicted gene 129
chr19_+_32757497 0.01 ENSMUST00000013807.7
phosphatase and tensin homolog
chr7_+_100537192 0.01 ENSMUST00000120454.1
cytochrome c oxidase assembly factor 4
chr2_-_128687354 0.00 ENSMUST00000110332.1
ENSMUST00000110333.1
ENSMUST00000014499.3
anaphase promoting complex subunit 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Rfx5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0046967 cytosol to ER transport(GO:0046967)
0.1 0.3 GO:0002587 negative regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002587)
0.1 0.9 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.0 0.1 GO:0015920 regulation of phosphatidylcholine catabolic process(GO:0010899) lipopolysaccharide transport(GO:0015920)
0.0 0.1 GO:0098971 anterograde dendritic transport of neurotransmitter receptor complex(GO:0098971)
0.0 0.1 GO:2000847 negative regulation of corticosteroid hormone secretion(GO:2000847) negative regulation of glucocorticoid secretion(GO:2000850)
0.0 0.1 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.0 0.3 GO:0007141 male meiosis I(GO:0007141)
0.0 0.2 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
0.0 0.0 GO:0042231 interleukin-1 biosynthetic process(GO:0042222) interleukin-13 biosynthetic process(GO:0042231)
0.0 0.1 GO:0015671 oxygen transport(GO:0015671)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 0.3 GO:0034991 nuclear meiotic cohesin complex(GO:0034991)
0.0 0.4 GO:0042825 TAP complex(GO:0042825)
0.0 0.0 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.0 0.2 GO:0005662 DNA replication factor A complex(GO:0005662)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
0.0 0.1 GO:0004771 sterol esterase activity(GO:0004771) retinyl-palmitate esterase activity(GO:0050253)
0.0 1.0 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.0 0.2 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.0 0.1 GO:0031127 galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.0 0.1 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.0 0.1 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.0 0.1 GO:0005344 oxygen transporter activity(GO:0005344)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.2 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand