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12D miR HR13_24

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Results for Nfat5

Z-value: 0.35

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Transcription factors associated with Nfat5

Gene Symbol Gene ID Gene Info
ENSMUSG00000003847.10 nuclear factor of activated T cells 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nfat5mm10_v2_chr8_+_107293463_107293483-0.372.7e-01Click!

Activity profile of Nfat5 motif

Sorted Z-values of Nfat5 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_141078188 0.72 ENSMUST00000106039.2
plakophilin 3
chr10_+_5639210 0.54 ENSMUST00000019906.4
vasoactive intestinal polypeptide
chr2_-_30415389 0.47 ENSMUST00000142096.1
carnitine acetyltransferase
chr4_+_134864536 0.41 ENSMUST00000030627.7
Rh blood group, D antigen
chr2_+_125136692 0.39 ENSMUST00000099452.2
cortexin 2
chr3_-_129755305 0.34 ENSMUST00000029653.2
epidermal growth factor
chr4_+_110397764 0.33 ENSMUST00000097920.2
ENSMUST00000080744.6
ATP/GTP binding protein-like 4
chrX_+_139684980 0.33 ENSMUST00000096313.3
TBC1 domain family, member 8B
chr4_+_110397661 0.31 ENSMUST00000106589.2
ENSMUST00000106587.2
ENSMUST00000106591.1
ENSMUST00000106592.1
ATP/GTP binding protein-like 4
chr3_-_27710413 0.30 ENSMUST00000046157.4
fibronectin type III domain containing 3B
chrX_+_72987339 0.29 ENSMUST00000164800.1
ENSMUST00000114546.2
zinc finger protein 185
chr5_-_105051047 0.28 ENSMUST00000112718.4
guanylate-binding protein 8
chr6_+_123262107 0.28 ENSMUST00000032240.2
C-type lectin domain family 4, member d
chr15_-_75894474 0.25 ENSMUST00000023237.6
nicotinate phosphoribosyltransferase domain containing 1
chr19_-_5845471 0.23 ENSMUST00000174287.1
ENSMUST00000173672.1
nuclear paraspeckle assembly transcript 1 (non-protein coding)
chr8_-_25091341 0.22 ENSMUST00000125466.1
pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2
chr10_+_112165676 0.22 ENSMUST00000170013.1
calcyphosphine 2
chrX_-_16817339 0.22 ENSMUST00000040820.6
monoamine oxidase B
chr7_-_126625676 0.22 ENSMUST00000032961.3
nuclear protein transcription regulator 1
chr1_+_88055467 0.21 ENSMUST00000173325.1
UDP glycosyltransferase 1 family, polypeptide A10
chr1_+_88070765 0.21 ENSMUST00000073772.4
UDP glucuronosyltransferase 1 family, polypeptide A9
chr17_-_34517352 0.19 ENSMUST00000075483.4
butyrophilin-like 6
chr1_+_88055377 0.19 ENSMUST00000138182.1
ENSMUST00000113142.3
UDP glycosyltransferase 1 family, polypeptide A10
chr6_+_120773633 0.19 ENSMUST00000112682.2
solute carrier family 25 (mitochondrial carrier), member 18
chr1_+_24678536 0.18 ENSMUST00000095062.3
LMBR1 domain containing 1
chr8_-_105979413 0.17 ENSMUST00000034371.7
dipeptidase 3
chr10_-_29535857 0.16 ENSMUST00000092623.3
R-spondin 3 homolog (Xenopus laevis)
chr10_+_21993890 0.16 ENSMUST00000092673.4
serum/glucocorticoid regulated kinase 1
chr16_+_84774361 0.15 ENSMUST00000098407.2
junction adhesion molecule 2
chr18_+_36560581 0.14 ENSMUST00000155329.2
ankyrin repeat and KH domain containing 1
chr7_+_99535439 0.14 ENSMUST00000098266.2
ENSMUST00000179755.1
arrestin, beta 1
chr17_-_34475937 0.14 ENSMUST00000065841.4
butyrophilin-like 4
chr11_+_119022962 0.13 ENSMUST00000026662.7
chromobox 2
chr10_-_109010955 0.12 ENSMUST00000105276.1
ENSMUST00000064054.7
synaptotagmin I
chr12_-_83597140 0.12 ENSMUST00000048319.4
zinc finger, FYVE domain containing 1
chr19_+_25236959 0.12 ENSMUST00000049400.8
KN motif and ankyrin repeat domains 1
chr16_-_79091078 0.12 ENSMUST00000023566.4
ENSMUST00000060402.5
transmembrane protease, serine 15
chr5_-_124354671 0.11 ENSMUST00000031341.4
CDK2 (cyclin-dependent kinase 2)-associated protein 1
chr10_-_62507737 0.11 ENSMUST00000020271.6
serglycin
chr4_+_3940747 0.11 ENSMUST00000119403.1
coiled-coil-helix-coiled-coil-helix domain containing 7
chr11_-_58570559 0.11 ENSMUST00000108822.2
olfactory receptor 224
chr16_+_84774123 0.11 ENSMUST00000114195.1
junction adhesion molecule 2
chrX_+_106583184 0.10 ENSMUST00000101296.2
ENSMUST00000101297.3
predicted gene 5127
chr10_+_21994666 0.09 ENSMUST00000020145.5
serum/glucocorticoid regulated kinase 1
chr10_-_95415484 0.09 ENSMUST00000172070.1
ENSMUST00000150432.1
suppressor of cytokine signaling 2
chr11_-_99493112 0.09 ENSMUST00000006969.7
keratin 23
chr5_+_139423151 0.09 ENSMUST00000066211.4
G protein-coupled estrogen receptor 1
chr6_-_142964404 0.09 ENSMUST00000032421.3
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr7_-_141918481 0.09 ENSMUST00000151890.1
toll interacting protein
chr12_+_35992900 0.09 ENSMUST00000020898.5
anterior gradient 2
chr6_+_91684061 0.09 ENSMUST00000032185.7
solute carrier family 6 (neurotransmitter transporter, taurine), member 6
chr10_-_95415283 0.08 ENSMUST00000119917.1
suppressor of cytokine signaling 2
chr18_+_36559972 0.07 ENSMUST00000134146.1
ankyrin repeat and KH domain containing 1
chr1_+_165485168 0.06 ENSMUST00000111440.1
ENSMUST00000027852.8
ENSMUST00000111439.1
adenylate cyclase 10
chr15_-_57265126 0.06 ENSMUST00000137764.1
ENSMUST00000022995.6
solute carrier family 22 (organic cation transporter), member 22
chr2_+_172549581 0.06 ENSMUST00000030391.2
transcription factor AP-2, gamma
chr19_+_20405280 0.06 ENSMUST00000179640.1
RIKEN cDNA 1500015L24 gene
chr13_-_113180897 0.06 ENSMUST00000038212.7
granzyme K
chr11_+_54370625 0.06 ENSMUST00000094193.2
RIKEN cDNA 4930404A10 gene
chr15_+_5185700 0.06 ENSMUST00000081640.5
tetratricopeptide repeat domain 33
chr19_+_10525244 0.06 ENSMUST00000038379.3
cleavage and polyadenylation specific factor 7
chr5_-_26089291 0.06 ENSMUST00000094946.4
predicted gene 10471
chr11_-_118401826 0.05 ENSMUST00000106290.3
ENSMUST00000043722.3
lectin, galactoside-binding, soluble, 3 binding protein
chr7_+_99535652 0.05 ENSMUST00000032995.8
ENSMUST00000162404.1
arrestin, beta 1
chr9_+_114515697 0.05 ENSMUST00000180393.1
RIKEN cDNA C130032M10 gene
chr11_+_95261529 0.05 ENSMUST00000021242.4
tachykinin 4
chr2_-_30415509 0.05 ENSMUST00000134120.1
ENSMUST00000102854.3
carnitine acetyltransferase
chrX_-_155216338 0.05 ENSMUST00000112551.3
spermidine/spermine N1-acetyl transferase 1
chr16_-_55838827 0.05 ENSMUST00000096026.2
ENSMUST00000036273.6
ENSMUST00000114457.1
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta
chrX_-_155216444 0.05 ENSMUST00000026318.8
spermidine/spermine N1-acetyl transferase 1
chr9_-_105521147 0.04 ENSMUST00000176770.1
ENSMUST00000085133.6
ATPase, Ca++-sequestering
chr7_+_20008023 0.04 ENSMUST00000073151.6
ENSMUST00000137183.1
NLR family, pyrin domain containing 9B
chr7_+_20019172 0.04 ENSMUST00000117909.1
NLR family, pyrin domain containing 9B
chrX_-_49797700 0.04 ENSMUST00000033442.7
ENSMUST00000114891.1
immunoglobulin superfamily, member 1
chr1_+_180945898 0.04 ENSMUST00000160508.1
ENSMUST00000160536.1
transmembrane protein 63a
chr9_+_7764041 0.04 ENSMUST00000052865.9
transmembrane protein 123
chr7_+_46847128 0.04 ENSMUST00000005051.4
lactate dehydrogenase A
chr1_+_5588493 0.03 ENSMUST00000160777.1
ENSMUST00000027038.4
opioid receptor, kappa 1
chr7_-_81493725 0.03 ENSMUST00000119121.1
adaptor-related protein complex 3, beta 2 subunit
chr6_-_92183972 0.03 ENSMUST00000140438.1
mitochondrial ribosomal protein S25
chr7_-_81493883 0.03 ENSMUST00000082090.7
adaptor-related protein complex 3, beta 2 subunit
chr7_-_43533171 0.03 ENSMUST00000004728.5
ENSMUST00000039861.5
CD33 antigen
chr7_+_110773658 0.03 ENSMUST00000143786.1
adenosine monophosphate deaminase 3
chr5_-_26039506 0.02 ENSMUST00000079447.2
spermatogenesis associated glutamate (E)-rich protein 4a
chr10_-_7663569 0.02 ENSMUST00000162606.1
protein-L-isoaspartate (D-aspartate) O-methyltransferase 1
chr3_-_145099024 0.02 ENSMUST00000040465.6
chloride channel calcium activated 5
chr12_+_84417196 0.02 ENSMUST00000183146.1
ring finger protein 113A2
chr9_-_7835255 0.02 ENSMUST00000074246.6
baculoviral IAP repeat-containing 2
chr11_+_9191934 0.01 ENSMUST00000042740.6
ATP-binding cassette, sub-family A (ABC1), member 13
chr3_-_70807284 0.01 ENSMUST00000180497.1
predicted gene 6634
chr4_-_82505707 0.01 ENSMUST00000107248.1
ENSMUST00000107247.1
nuclear factor I/B
chr4_-_49506538 0.01 ENSMUST00000043056.2
bile acid-Coenzyme A: amino acid N-acyltransferase
chr16_+_92058270 0.01 ENSMUST00000047429.8
ENSMUST00000113975.2
mitochondrial ribosomal protein S6
solute carrier family 5 (inositol transporters), member 3
chr2_-_177925604 0.01 ENSMUST00000108934.2
ENSMUST00000081529.4
RIKEN cDNA C330013J21 gene
chr11_+_120491840 0.01 ENSMUST00000026899.3
solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10
chr1_+_83159733 0.01 ENSMUST00000113436.1
ENSMUST00000065436.3
ENSMUST00000065403.6
dynein assembly factor with WDR repeat domains 1
chr3_-_40509737 0.01 ENSMUST00000179966.1
RIKEN cDNA 1700017G19 gene
chr5_-_137871739 0.01 ENSMUST00000164886.1
paired immunoglobin-like type 2 receptor beta 2
chr15_-_38078842 0.01 ENSMUST00000110336.2
ubiquitin protein ligase E3 component n-recognin 5
chr5_+_120511168 0.00 ENSMUST00000068326.7
solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
chr6_-_129275360 0.00 ENSMUST00000032259.3
CD69 antigen
chr10_-_78351690 0.00 ENSMUST00000166360.1
1-acylglycerol-3-phosphate O-acyltransferase 3
chr1_+_88406956 0.00 ENSMUST00000027518.5
secreted phosphoprotein 2

Network of associatons between targets according to the STRING database.

First level regulatory network of Nfat5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.1 0.4 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.1 0.6 GO:0010579 regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579)
0.1 0.7 GO:0002159 desmosome assembly(GO:0002159)
0.1 0.5 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.1 0.3 GO:0007262 STAT protein import into nucleus(GO:0007262)
0.1 0.2 GO:0045062 extrathymic T cell selection(GO:0045062)
0.1 0.3 GO:0038094 Fc-gamma receptor signaling pathway(GO:0038094)
0.1 0.6 GO:0052696 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.0 0.1 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.0 0.2 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.0 0.1 GO:0033367 protein localization to secretory granule(GO:0033366) protein localization to mast cell secretory granule(GO:0033367) protease localization to mast cell secretory granule(GO:0033368) maintenance of protein location in mast cell secretory granule(GO:0033370) T cell secretory granule organization(GO:0033371) maintenance of protease location in mast cell secretory granule(GO:0033373) protein localization to T cell secretory granule(GO:0033374) protease localization to T cell secretory granule(GO:0033375) maintenance of protein location in T cell secretory granule(GO:0033377) maintenance of protease location in T cell secretory granule(GO:0033379) granzyme B localization to T cell secretory granule(GO:0033380) maintenance of granzyme B location in T cell secretory granule(GO:0033382)
0.0 0.2 GO:0014063 negative regulation of serotonin secretion(GO:0014063)
0.0 0.1 GO:0032917 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
0.0 0.1 GO:1903896 positive regulation of IRE1-mediated unfolded protein response(GO:1903896)
0.0 0.1 GO:0071718 sodium-independent icosanoid transport(GO:0071718)
0.0 0.3 GO:0060510 Type II pneumocyte differentiation(GO:0060510)
0.0 0.2 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.0 0.1 GO:0046877 regulation of saliva secretion(GO:0046877)
0.0 0.1 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.0 0.1 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.2 GO:2000194 regulation of female gonad development(GO:2000194)
0.0 0.0 GO:0030026 cellular manganese ion homeostasis(GO:0030026) Golgi calcium ion homeostasis(GO:0032468) manganese ion homeostasis(GO:0055071)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0005914 spot adherens junction(GO:0005914)
0.0 0.1 GO:0097629 extrinsic component of omegasome membrane(GO:0097629)
0.0 0.2 GO:0042382 paraspeckles(GO:0042382)
0.0 0.1 GO:0042629 mast cell granule(GO:0042629)
0.0 0.2 GO:0031143 pseudopodium(GO:0031143)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092)
0.1 0.2 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.0 0.7 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.2 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.0 0.1 GO:0004145 diamine N-acetyltransferase activity(GO:0004145)
0.0 0.2 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0 0.1 GO:0030348 syntaxin-3 binding(GO:0030348)
0.0 0.1 GO:0017082 mineralocorticoid receptor activity(GO:0017082)
0.0 0.1 GO:0030977 taurine binding(GO:0030977)
0.0 0.2 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.2 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.6 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.2 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.1 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
0.0 0.6 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.4 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.0 0.3 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.1 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.3 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.2 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.2 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 0.0 GO:0015410 manganese-transporting ATPase activity(GO:0015410)
0.0 0.3 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID ERBB NETWORK PATHWAY ErbB receptor signaling network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.5 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.3 REACTOME SHC1 EVENTS IN EGFR SIGNALING Genes involved in SHC1 events in EGFR signaling
0.0 0.2 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0 0.5 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 0.1 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle