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12D miR HR13_24

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Results for Foxa2_Foxa1

Z-value: 2.39

Motif logo

Transcription factors associated with Foxa2_Foxa1

Gene Symbol Gene ID Gene Info
ENSMUSG00000037025.5 forkhead box A2
ENSMUSG00000035451.6 forkhead box A1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Foxa2mm10_v2_chr2_-_148045891_148045948-0.821.9e-03Click!
Foxa1mm10_v2_chr12_-_57546121_57546141-0.471.5e-01Click!

Activity profile of Foxa2_Foxa1 motif

Sorted Z-values of Foxa2_Foxa1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_104766308 19.00 ENSMUST00000031663.3
complement component 8, beta polypeptide
chr4_+_104766334 18.22 ENSMUST00000065072.6
complement component 8, beta polypeptide
chr2_-_62483637 11.56 ENSMUST00000136686.1
ENSMUST00000102733.3
glucagon
chr10_+_115817247 8.66 ENSMUST00000035563.7
ENSMUST00000080630.3
ENSMUST00000179196.1
tetraspanin 8
chr4_-_57916283 8.23 ENSMUST00000063816.5
RIKEN cDNA D630039A03 gene
chr5_-_86906937 7.63 ENSMUST00000031181.9
ENSMUST00000113333.1
UDP glucuronosyltransferase 2 family, polypeptide B34
chrX_-_108664891 6.34 ENSMUST00000178160.1
predicted gene 379
chr3_-_113532288 6.26 ENSMUST00000132353.1
amylase 2a1
chr6_+_90619241 5.35 ENSMUST00000032177.8
solute carrier family 41, member 3
chr14_+_41131777 5.32 ENSMUST00000022314.3
ENSMUST00000170719.1
surfactant associated protein A1
chrX_+_164140447 5.04 ENSMUST00000073973.4
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr3_-_113258837 4.94 ENSMUST00000098673.3
amylase 2a5
chr11_+_96929260 4.79 ENSMUST00000054311.5
ENSMUST00000107636.3
proline rich 15-like
chr11_+_96929367 4.69 ENSMUST00000062172.5
proline rich 15-like
chr16_-_22439719 4.55 ENSMUST00000079601.6
ets variant gene 5
chr14_+_103513328 3.84 ENSMUST00000095576.3
sciellin
chr14_-_110755100 3.79 ENSMUST00000078386.2
SLIT and NTRK-like family, member 6
chr17_+_70522083 3.70 ENSMUST00000148486.1
ENSMUST00000133717.1
discs, large (Drosophila) homolog-associated protein 1
chr11_-_99993992 3.55 ENSMUST00000105049.1
keratin associated protein 17-1
chr6_+_5390387 3.55 ENSMUST00000183358.1
ankyrin repeat and SOCS box-containing 4
chr14_-_41185188 3.54 ENSMUST00000077136.3
surfactant associated protein D
chr15_+_10223974 3.54 ENSMUST00000128450.1
ENSMUST00000148257.1
ENSMUST00000128921.1
prolactin receptor
chr6_+_30541582 3.38 ENSMUST00000096066.4
carboxypeptidase A2, pancreatic
chr5_+_75152274 3.33 ENSMUST00000000476.8
platelet derived growth factor receptor, alpha polypeptide
chrX_+_101376359 2.89 ENSMUST00000119080.1
gap junction protein, beta 1
chr10_-_93310963 2.84 ENSMUST00000151153.1
ELK3, member of ETS oncogene family
chr16_+_17331371 2.82 ENSMUST00000023450.6
ENSMUST00000161034.1
serine (or cysteine) peptidase inhibitor, clade D, member 1
chr13_-_95478655 2.79 ENSMUST00000022186.3
S100 calcium binding protein, zeta
chr4_+_102570065 2.76 ENSMUST00000097950.2
phosphodiesterase 4B, cAMP specific
chr4_-_127354074 2.58 ENSMUST00000106090.1
ENSMUST00000060419.1
gap junction protein, beta 4
chr5_+_102481374 2.56 ENSMUST00000094559.2
ENSMUST00000073302.5
Rho GTPase activating protein 24
chr6_-_136922169 2.48 ENSMUST00000032343.6
endoplasmic reticulum protein 27
chr17_-_31144271 2.48 ENSMUST00000024826.7
trefoil factor 2 (spasmolytic protein 1)
chr5_+_102481546 2.47 ENSMUST00000112854.1
Rho GTPase activating protein 24
chr14_+_73237891 2.46 ENSMUST00000044405.6
lysophosphatidic acid receptor 6
chr1_-_39720989 2.42 ENSMUST00000151913.1
regulatory factor X 8
chr6_+_142298419 2.39 ENSMUST00000041993.2
islet amyloid polypeptide
chr3_+_106486009 2.36 ENSMUST00000183271.1
ENSMUST00000061206.3
DENN/MADD domain containing 2D
chr6_+_97991776 2.36 ENSMUST00000043628.6
microphthalmia-associated transcription factor
chr2_+_24345282 2.30 ENSMUST00000114485.2
interleukin 1 receptor antagonist
chr1_+_157526127 2.29 ENSMUST00000111700.1
SEC16 homolog B (S. cerevisiae)
chr11_-_99986593 2.22 ENSMUST00000105050.2
keratin associated protein 16-1
chr13_-_95525239 2.19 ENSMUST00000022185.8
coagulation factor II (thrombin) receptor-like 1
chr2_+_58755177 2.19 ENSMUST00000102755.3
uridine phosphorylase 2
chr10_-_93311073 2.17 ENSMUST00000008542.5
ELK3, member of ETS oncogene family
chr3_-_20275659 2.13 ENSMUST00000011607.5
carboxypeptidase B1 (tissue)
chr3_-_106167564 2.11 ENSMUST00000063062.8
chitinase 3-like 3
chr17_+_70522149 2.08 ENSMUST00000140728.1
discs, large (Drosophila) homolog-associated protein 1
chr7_+_131032061 2.08 ENSMUST00000084509.3
deleted in malignant brain tumors 1
chr5_-_108795352 2.04 ENSMUST00000004943.1
transmembrane emp24 protein transport domain containing
chr6_+_92940572 2.04 ENSMUST00000181145.1
ENSMUST00000181840.1
RIKEN cDNA 9530026P05 gene
chr4_-_58499398 1.92 ENSMUST00000107570.1
lysophosphatidic acid receptor 1
chr5_+_16553488 1.90 ENSMUST00000030683.3
hepatocyte growth factor
chr2_+_58754910 1.88 ENSMUST00000059102.6
uridine phosphorylase 2
chr2_+_24345305 1.82 ENSMUST00000114482.1
interleukin 1 receptor antagonist
chr10_-_41611319 1.80 ENSMUST00000179614.1
coiled-coil domain containing 162
chr13_+_40859768 1.80 ENSMUST00000110191.2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr11_-_100146120 1.73 ENSMUST00000007317.7
keratin 19
chr8_+_107119110 1.65 ENSMUST00000046116.1
RIKEN cDNA C630050I24 gene
chr5_-_123865491 1.62 ENSMUST00000057145.5
niacin receptor 1
chr6_+_34863130 1.61 ENSMUST00000074949.3
transmembrane protein 140
chr3_+_106113229 1.60 ENSMUST00000079132.5
ENSMUST00000139086.1
chitinase, acidic
chr7_-_100656953 1.59 ENSMUST00000107046.1
ENSMUST00000107045.1
ENSMUST00000139708.1
pleckstrin homology domain containing, family B (evectins) member 1
chr14_-_30943275 1.57 ENSMUST00000006704.8
ENSMUST00000163118.1
inter-alpha trypsin inhibitor, heavy chain 1
chr1_-_74885322 1.54 ENSMUST00000159232.1
ENSMUST00000068631.3
FEV (ETS oncogene family)
chr15_-_84855093 1.52 ENSMUST00000016768.5
PHD finger protein 21B
chr3_-_145032765 1.50 ENSMUST00000029919.5
chloride channel calcium activated 3
chr15_-_66560997 1.47 ENSMUST00000048372.5
transmembrane protein 71
chr18_+_36952621 1.46 ENSMUST00000115661.2
protocadherin alpha 2
chr2_+_164403194 1.45 ENSMUST00000017151.1
recombination signal binding protein for immunoglobulin kappa J region-like
chr12_+_71016658 1.44 ENSMUST00000125125.1
AT rich interactive domain 4A (RBP1-like)
chr19_-_58455398 1.42 ENSMUST00000026076.7
glial cell line derived neurotrophic factor family receptor alpha 1
chr11_+_94565039 1.41 ENSMUST00000040418.8
chondroadherin
chr14_+_55853997 1.39 ENSMUST00000100529.3
NYN domain and retroviral integrase containing
chr2_-_51973219 1.37 ENSMUST00000028314.2
N-myc (and STAT) interactor
chr16_-_22161450 1.37 ENSMUST00000115379.1
insulin-like growth factor 2 mRNA binding protein 2
chr8_+_70373541 1.35 ENSMUST00000003659.7
cartilage oligomeric matrix protein
chr2_-_70825726 1.32 ENSMUST00000038584.8
tousled-like kinase 1
chr11_+_110399115 1.32 ENSMUST00000020949.5
ENSMUST00000100260.1
mitogen-activated protein kinase kinase 6
chr19_+_38264761 1.32 ENSMUST00000087252.5
leucine-rich repeat LGI family, member 1
chr8_+_127064022 1.31 ENSMUST00000160272.1
ENSMUST00000079777.5
ENSMUST00000162907.1
par-3 (partitioning defective 3) homolog (C. elegans)
chr14_+_55854115 1.28 ENSMUST00000168479.1
NYN domain and retroviral integrase containing
chr2_-_104742802 1.27 ENSMUST00000028595.7
DEP domain containing 7
chr16_-_22657165 1.26 ENSMUST00000089925.3
diacylglycerol kinase, gamma
chr1_+_179546303 1.25 ENSMUST00000040706.8
consortin, connexin sorting protein
chr2_+_24336846 1.24 ENSMUST00000114487.2
interleukin 1 receptor antagonist
chr19_+_55741810 1.23 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
transcription factor 7 like 2, T cell specific, HMG box
chr16_-_74411292 1.20 ENSMUST00000117200.1
roundabout homolog 2 (Drosophila)
chr16_-_22657182 1.19 ENSMUST00000023578.7
diacylglycerol kinase, gamma
chr19_-_58455161 1.18 ENSMUST00000135730.1
ENSMUST00000152507.1
glial cell line derived neurotrophic factor family receptor alpha 1
chr18_-_38918642 1.18 ENSMUST00000040647.4
fibroblast growth factor 1
chr7_+_19359740 1.18 ENSMUST00000140836.1
protein phosphatase 1, regulatory (inhibitor) subunit 13 like
chr11_+_87699897 1.16 ENSMUST00000040089.4
ring finger protein 43
chr6_+_139843648 1.15 ENSMUST00000087657.6
phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide
chr4_+_102254993 1.13 ENSMUST00000106908.2
phosphodiesterase 4B, cAMP specific
chr13_-_60177357 1.10 ENSMUST00000065086.4
growth arrest specific 1
chr14_+_61607455 1.09 ENSMUST00000051184.8
potassium channel regulator
chr2_+_69219971 1.08 ENSMUST00000005364.5
ENSMUST00000112317.2
glucose-6-phosphatase, catalytic, 2
chr2_-_51972990 1.08 ENSMUST00000145481.1
ENSMUST00000112705.2
N-myc (and STAT) interactor
chr1_-_156034826 1.06 ENSMUST00000141878.1
ENSMUST00000123705.1
torsin A interacting protein 1
chr19_+_55741884 1.05 ENSMUST00000111658.3
ENSMUST00000111654.1
transcription factor 7 like 2, T cell specific, HMG box
chr18_+_51117754 1.05 ENSMUST00000116639.2
proline rich 16
chr1_-_87573825 1.04 ENSMUST00000068681.5
neuronal guanine nucleotide exchange factor
chr2_-_163645125 1.03 ENSMUST00000017851.3
serine incorporator 3
chr1_-_156034800 1.02 ENSMUST00000169241.1
torsin A interacting protein 1
chr15_+_5185700 1.02 ENSMUST00000081640.5
tetratricopeptide repeat domain 33
chr2_+_30595037 1.01 ENSMUST00000102853.3
CSA-conditional, T cell activation-dependent protein
chr11_+_114851142 1.00 ENSMUST00000133245.1
ENSMUST00000122967.2
G protein-coupled receptor, family C, group 5, member C
chr6_+_29853746 1.00 ENSMUST00000064872.6
ENSMUST00000152581.1
ENSMUST00000176265.1
ENSMUST00000154079.1
S-adenosylhomocysteine hydrolase-like 2
chr14_-_88471396 0.98 ENSMUST00000061628.5
protocadherin 20
chrX_+_159708593 0.98 ENSMUST00000080394.6
SH3-domain kinase binding protein 1
chr4_+_11123950 0.96 ENSMUST00000142297.1
predicted gene 11827
chr16_-_38294774 0.95 ENSMUST00000023504.4
nuclear receptor subfamily 1, group I, member 2
chr17_+_68837062 0.95 ENSMUST00000178545.1
transmembrane protein 200C
chr18_-_62756275 0.95 ENSMUST00000067450.1
ENSMUST00000048109.5
RIKEN cDNA 2700046A07 gene
chr18_+_69925466 0.94 ENSMUST00000043929.4
coiled-coil domain containing 68
chr3_-_69859875 0.92 ENSMUST00000051239.7
ENSMUST00000171529.1
serine palmitoyltransferase, small subunit B
chr11_+_115824029 0.91 ENSMUST00000103032.4
ENSMUST00000133250.1
ENSMUST00000177736.1
lethal giant larvae homolog 2 (Drosophila)
chr12_-_31950535 0.91 ENSMUST00000172314.2
high mobility group box transcription factor 1
chr4_+_150853919 0.91 ENSMUST00000073600.2
ERBB receptor feedback inhibitor 1
chr13_-_74807913 0.90 ENSMUST00000065629.4
calpastatin
chr2_-_60722636 0.89 ENSMUST00000028348.2
ENSMUST00000112517.1
integrin beta 6
chr13_+_111867931 0.89 ENSMUST00000128198.1
predicted gene 15326
chr1_-_166409773 0.88 ENSMUST00000135673.1
ENSMUST00000079972.6
ENSMUST00000169324.1
ENSMUST00000111411.2
ENSMUST00000128861.1
pogo transposable element with KRAB domain
chr3_-_113324052 0.88 ENSMUST00000179314.1
amylase 2a3
chr6_+_15185203 0.88 ENSMUST00000154448.1
forkhead box P2
chr18_+_69925542 0.88 ENSMUST00000080050.5
coiled-coil domain containing 68
chr3_-_113291449 0.87 ENSMUST00000179568.1
amylase 2a4
chr15_-_3303521 0.87 ENSMUST00000165386.1
coiled-coil domain containing 152
chr9_+_107975529 0.86 ENSMUST00000035216.4
ubiquitin-like modifier activating enzyme 7
chr15_-_5108492 0.85 ENSMUST00000118365.2
caspase recruitment domain family, member 6
chr5_-_51567717 0.85 ENSMUST00000127135.1
ENSMUST00000151104.1
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
chr2_-_170194033 0.84 ENSMUST00000180625.1
predicted gene, 17619
chr7_+_78913401 0.84 ENSMUST00000118867.1
interferon-stimulated protein
chr9_+_74848437 0.83 ENSMUST00000161862.1
ENSMUST00000162089.1
ENSMUST00000160017.1
ENSMUST00000160950.1
predicted gene 16551
predicted gene 20649
chr14_-_93888732 0.83 ENSMUST00000068992.2
protocadherin 9
chr1_-_170867761 0.83 ENSMUST00000027974.6
activating transcription factor 6
chr18_-_84086379 0.83 ENSMUST00000060303.8
teashirt zinc finger family member 1
chr19_+_55742056 0.82 ENSMUST00000111659.2
transcription factor 7 like 2, T cell specific, HMG box
chr2_+_160888101 0.82 ENSMUST00000109455.2
ENSMUST00000040872.6
lipin 3
chr7_-_29168647 0.81 ENSMUST00000048923.6
sprouty-related, EVH1 domain containing 3
chr5_-_103211251 0.80 ENSMUST00000060871.5
ENSMUST00000112846.1
ENSMUST00000170792.1
ENSMUST00000112847.2
mitogen-activated protein kinase 10
chr2_+_125136692 0.80 ENSMUST00000099452.2
cortexin 2
chr12_+_77238093 0.79 ENSMUST00000177595.1
ENSMUST00000171770.2
fucosyltransferase 8
chr6_-_137571007 0.78 ENSMUST00000100841.2
epidermal growth factor receptor pathway substrate 8
chr17_+_46161021 0.78 ENSMUST00000024748.7
ENSMUST00000172170.1
GTP binding protein 2
chr8_-_45262012 0.78 ENSMUST00000034064.3
coagulation factor XI
chr3_-_52104891 0.77 ENSMUST00000121440.1
mastermind like 3 (Drosophila)
chr15_-_50890396 0.77 ENSMUST00000185183.1
trichorhinophalangeal syndrome I (human)
chr9_-_99710063 0.77 ENSMUST00000035048.5
claudin 18
chr1_+_9848270 0.76 ENSMUST00000171265.1
serum/glucocorticoid regulated kinase 3
chr6_+_134830145 0.76 ENSMUST00000046303.5
cAMP responsive element binding protein-like 2
chr5_+_95956916 0.75 ENSMUST00000023840.5
chemokine (C-X-C motif) ligand 13
chr4_+_98546710 0.75 ENSMUST00000102792.3
InaD-like (Drosophila)
chr4_+_43669610 0.75 ENSMUST00000107866.1
transmembrane protein 8B
chr13_+_112467504 0.74 ENSMUST00000183868.1
interleukin 6 signal transducer
chr7_+_78913436 0.74 ENSMUST00000121645.1
interferon-stimulated protein
chr3_+_137867675 0.74 ENSMUST00000090178.5
DnaJ (Hsp40) homolog, subfamily B, member 14
chr17_+_46161111 0.74 ENSMUST00000166563.1
GTP binding protein 2
chr16_-_26526744 0.73 ENSMUST00000165687.1
transmembrane protein 207
chr13_-_12464925 0.73 ENSMUST00000124888.1
lectin, galactose binding, soluble 8
chr1_+_9848375 0.71 ENSMUST00000097826.4
serum/glucocorticoid regulated kinase 3
chr18_-_3281036 0.71 ENSMUST00000049942.6
ENSMUST00000139537.1
ENSMUST00000124747.1
cAMP responsive element modulator
chr15_+_5185519 0.70 ENSMUST00000118193.1
ENSMUST00000022751.8
tetratricopeptide repeat domain 33
chr9_+_86743641 0.70 ENSMUST00000179574.1
protease, serine, 35
chr7_+_90426312 0.69 ENSMUST00000061391.7
coiled-coil domain containing 89
chrX_+_136707976 0.69 ENSMUST00000055104.5
transcription elongation factor A (SII)-like 1
chr7_+_78913765 0.69 ENSMUST00000038142.8
interferon-stimulated protein
chr8_-_45294854 0.69 ENSMUST00000116473.2
kallikrein B, plasma 1
chr5_-_17888884 0.67 ENSMUST00000169095.1
CD36 antigen
chr6_-_41446062 0.67 ENSMUST00000095999.5
predicted gene 10334
chr16_+_24448082 0.67 ENSMUST00000078988.2
LIM domain containing preferred translocation partner in lipoma
chr3_+_135825648 0.66 ENSMUST00000180196.1
solute carrier family 39 (metal ion transporter), member 8
chr7_+_43351378 0.66 ENSMUST00000012798.7
ENSMUST00000122423.1
ENSMUST00000121494.1
sialic acid binding Ig-like lectin 5
chr10_+_52391606 0.66 ENSMUST00000067085.4
nephrocan
chr8_+_45658731 0.65 ENSMUST00000143820.1
ENSMUST00000132139.1
sorbin and SH3 domain containing 2
chr1_-_126830632 0.65 ENSMUST00000112583.1
ENSMUST00000094609.3
NCK-associated protein 5
chr9_+_43744399 0.65 ENSMUST00000034510.7
poliovirus receptor-related 1
chr4_+_98546919 0.65 ENSMUST00000030290.7
InaD-like (Drosophila)
chr7_-_34655500 0.64 ENSMUST00000032709.1
potassium channel tetramerisation domain containing 15
chr5_-_66151903 0.63 ENSMUST00000167950.1
RNA binding motif protein 47
chr3_+_27154020 0.63 ENSMUST00000181124.1
RIKEN cDNA 1700125G22 gene
chr5_+_107437908 0.62 ENSMUST00000094541.2
BTB (POZ) domain containing 8
chr8_-_8639363 0.60 ENSMUST00000152698.1
ephrin B2
chr2_-_90479165 0.60 ENSMUST00000111495.2
protein tyrosine phosphatase, receptor type, J
chr19_+_26749726 0.59 ENSMUST00000175842.1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr7_-_142661858 0.58 ENSMUST00000145896.2
insulin-like growth factor 2
chr2_+_52072823 0.57 ENSMUST00000112693.2
ENSMUST00000069794.5
Rap1 interacting factor 1 homolog (yeast)
chr2_-_18048784 0.57 ENSMUST00000142856.1
SKI/DACH domain containing 1
chr1_-_138619687 0.56 ENSMUST00000027642.2
NIMA (never in mitosis gene a)-related expressed kinase 7
chr14_-_121915774 0.56 ENSMUST00000055475.7
G protein-coupled receptor 18
chr18_+_37742088 0.55 ENSMUST00000003599.6
protocadherin gamma subfamily A, 9
chr3_-_131344892 0.55 ENSMUST00000090246.4
ENSMUST00000126569.1
sphingomyelin synthase 2
chr8_-_85380964 0.55 ENSMUST00000122452.1
myosin light chain kinase 3
chr5_-_66054499 0.54 ENSMUST00000145625.1
RNA binding motif protein 47
chr1_+_43445736 0.54 ENSMUST00000086421.5
ENSMUST00000114744.1
non-catalytic region of tyrosine kinase adaptor protein 2
chr19_+_26623419 0.54 ENSMUST00000176584.1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr2_-_66256576 0.54 ENSMUST00000125446.2
ENSMUST00000102718.3
tetratricopeptide repeat domain 21B
chr12_+_119443410 0.54 ENSMUST00000048880.6
metastasis associated in colon cancer 1
chr19_+_42090422 0.53 ENSMUST00000066778.4
phosphatidylinositol 4-kinase type 2 alpha

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxa2_Foxa1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 37.2 GO:0006957 complement activation, alternative pathway(GO:0006957)
1.7 11.6 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
1.3 5.0 GO:0015801 aromatic amino acid transport(GO:0015801) tryptophan transport(GO:0015827)
1.1 3.3 GO:0072277 metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
1.1 5.3 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
1.0 8.9 GO:0008228 opsonization(GO:0008228)
0.9 3.8 GO:0060005 vestibular reflex(GO:0060005)
0.8 2.5 GO:1902524 positive regulation of protein K48-linked ubiquitination(GO:1902524)
0.7 2.2 GO:1900135 positive regulation of eosinophil degranulation(GO:0043311) regulation of neutrophil mediated cytotoxicity(GO:0070948) regulation of neutrophil mediated killing of symbiont cell(GO:0070949) positive regulation of renin secretion into blood stream(GO:1900135) positive regulation of eosinophil activation(GO:1902568)
0.7 4.0 GO:0042078 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.6 2.4 GO:0097647 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.6 3.5 GO:0038161 prolactin signaling pathway(GO:0038161)
0.6 5.0 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.5 1.9 GO:1904566 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.5 2.3 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.4 5.8 GO:0070842 aggresome assembly(GO:0070842)
0.4 1.2 GO:0090004 positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.4 2.5 GO:0060455 negative regulation of gastric acid secretion(GO:0060455)
0.4 1.2 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.4 1.5 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.3 3.1 GO:0044334 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) embryonic hindgut morphogenesis(GO:0048619)
0.3 4.4 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.3 2.7 GO:0015074 DNA integration(GO:0015074)
0.3 3.5 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.3 1.6 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
0.3 1.5 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.3 1.8 GO:0036438 maintenance of lens transparency(GO:0036438)
0.3 2.9 GO:0015868 purine ribonucleotide transport(GO:0015868)
0.3 0.8 GO:2001205 negative regulation of osteoclast development(GO:2001205)
0.2 0.7 GO:0070104 negative regulation of interleukin-6-mediated signaling pathway(GO:0070104)
0.2 1.4 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
0.2 1.0 GO:0042738 exogenous drug catabolic process(GO:0042738)
0.2 2.4 GO:0044336 canonical Wnt signaling pathway involved in negative regulation of apoptotic process(GO:0044336)
0.2 2.3 GO:0048208 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.2 0.9 GO:0016332 establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
0.2 0.7 GO:0070543 response to linoleic acid(GO:0070543)
0.2 1.3 GO:0003383 apical constriction(GO:0003383)
0.2 0.8 GO:2000182 regulation of progesterone biosynthetic process(GO:2000182)
0.2 2.1 GO:0071763 nuclear membrane organization(GO:0071763)
0.2 1.0 GO:0009597 detection of virus(GO:0009597)
0.2 0.8 GO:0046368 GDP-L-fucose metabolic process(GO:0046368)
0.2 0.8 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.2 1.2 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.2 1.5 GO:0051611 regulation of serotonin uptake(GO:0051611)
0.2 0.6 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034)
0.2 0.8 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634) negative regulation of endothelial cell chemotaxis(GO:2001027)
0.2 8.7 GO:0030195 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.2 0.6 GO:0002305 gamma-delta intraepithelial T cell differentiation(GO:0002304) CD8-positive, gamma-delta intraepithelial T cell differentiation(GO:0002305)
0.2 0.5 GO:0045575 basophil activation involved in immune response(GO:0002276) basophil activation(GO:0045575)
0.2 0.7 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.2 1.9 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665) regulation of tau-protein kinase activity(GO:1902947)
0.2 2.6 GO:0042048 olfactory behavior(GO:0042048)
0.2 0.5 GO:0061144 epithelial cell maturation involved in prostate gland development(GO:0060743) alveolar secondary septum development(GO:0061144)
0.2 0.8 GO:0060023 soft palate development(GO:0060023)
0.2 0.3 GO:1903972 regulation of macrophage colony-stimulating factor signaling pathway(GO:1902226) regulation of response to macrophage colony-stimulating factor(GO:1903969) regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903972)
0.2 0.5 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.2 0.9 GO:1903243 negative regulation of tumor necrosis factor biosynthetic process(GO:0042536) negative regulation of cardiac muscle hypertrophy in response to stress(GO:1903243)
0.2 1.5 GO:0016554 cytidine to uridine editing(GO:0016554)
0.1 0.9 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.1 1.0 GO:1904220 regulation of serine C-palmitoyltransferase activity(GO:1904220)
0.1 1.2 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.1 0.5 GO:0002528 regulation of vascular permeability involved in acute inflammatory response(GO:0002528)
0.1 0.5 GO:1903898 positive regulation of translation in response to endoplasmic reticulum stress(GO:0036493) negative regulation of PERK-mediated unfolded protein response(GO:1903898)
0.1 0.8 GO:0007258 JUN phosphorylation(GO:0007258)
0.1 0.7 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.1 0.9 GO:0038044 transforming growth factor-beta secretion(GO:0038044)
0.1 1.0 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.1 0.7 GO:0002317 plasma cell differentiation(GO:0002317)
0.1 1.3 GO:0032308 positive regulation of prostaglandin secretion(GO:0032308)
0.1 0.4 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.1 0.3 GO:0071895 negative regulation of interleukin-13 production(GO:0032696) odontoblast differentiation(GO:0071895)
0.1 0.5 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 1.6 GO:0010745 negative regulation of macrophage derived foam cell differentiation(GO:0010745)
0.1 1.0 GO:0042473 outer ear morphogenesis(GO:0042473)
0.1 0.3 GO:0002784 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) regulation of antimicrobial peptide production(GO:0002784) regulation of antibacterial peptide production(GO:0002786) positive regulation of antibacterial peptide production(GO:0002803)
0.1 2.1 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.1 1.4 GO:0060346 bone trabecula formation(GO:0060346)
0.1 0.9 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.1 1.0 GO:0061002 negative regulation of dendritic spine morphogenesis(GO:0061002)
0.1 1.3 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.1 0.6 GO:1903849 regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.1 0.3 GO:2000297 negative regulation of synapse maturation(GO:2000297)
0.1 0.3 GO:0002370 natural killer cell cytokine production(GO:0002370) regulation of natural killer cell cytokine production(GO:0002727)
0.1 4.2 GO:0046834 lipid phosphorylation(GO:0046834)
0.1 0.4 GO:0046909 intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445)
0.1 0.5 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.1 0.3 GO:0055130 D-serine catabolic process(GO:0036088) D-alanine family amino acid metabolic process(GO:0046144) D-alanine metabolic process(GO:0046436) D-alanine catabolic process(GO:0055130)
0.1 0.3 GO:0010248 establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)
0.1 0.8 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.1 0.3 GO:0030043 actin filament fragmentation(GO:0030043)
0.1 0.2 GO:1904882 pre-B cell allelic exclusion(GO:0002331) signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434) telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
0.1 0.5 GO:0050847 progesterone receptor signaling pathway(GO:0050847)
0.1 0.2 GO:0002182 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.1 0.4 GO:0021993 initiation of neural tube closure(GO:0021993)
0.1 0.6 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.1 2.0 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.1 0.2 GO:1904798 negative regulation of interleukin-8 biosynthetic process(GO:0045415) positive regulation of core promoter binding(GO:1904798)
0.1 0.8 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.1 0.7 GO:0015691 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.1 0.2 GO:1900106 hyaluranon cable assembly(GO:0036118) monocyte aggregation(GO:0070487) kidney mesenchyme morphogenesis(GO:0072131) metanephric mesenchyme morphogenesis(GO:0072133) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.1 0.7 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.1 0.4 GO:0071896 protein localization to adherens junction(GO:0071896)
0.1 1.1 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.1 0.2 GO:0007525 somatic muscle development(GO:0007525)
0.1 0.8 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.1 0.2 GO:0097401 synaptic vesicle lumen acidification(GO:0097401)
0.1 0.3 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.1 0.2 GO:0015851 nucleobase transport(GO:0015851) pyrimidine nucleobase transport(GO:0015855)
0.0 0.3 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.0 0.4 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 1.6 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.0 1.1 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
0.0 1.2 GO:0003215 cardiac right ventricle morphogenesis(GO:0003215)
0.0 0.3 GO:0045925 positive regulation of female receptivity(GO:0045925)
0.0 0.2 GO:0035524 proline transmembrane transport(GO:0035524)
0.0 1.0 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.2 GO:0061589 calcium activated phosphatidylserine scrambling(GO:0061589)
0.0 1.7 GO:0060706 cell differentiation involved in embryonic placenta development(GO:0060706)
0.0 1.5 GO:2001240 negative regulation of signal transduction in absence of ligand(GO:1901099) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.0 0.5 GO:0051132 NK T cell activation(GO:0051132)
0.0 0.2 GO:1904073 regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
0.0 0.6 GO:0043116 negative regulation of vascular permeability(GO:0043116)
0.0 4.3 GO:0009166 nucleotide catabolic process(GO:0009166)
0.0 0.4 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.4 GO:0001696 gastric acid secretion(GO:0001696)
0.0 0.5 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.0 0.5 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 0.4 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.3 GO:0021559 trigeminal nerve development(GO:0021559)
0.0 0.3 GO:0031179 peptide modification(GO:0031179)
0.0 0.6 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.0 0.1 GO:0006447 regulation of translational initiation by iron(GO:0006447) positive regulation of translational initiation by iron(GO:0045994)
0.0 0.5 GO:0044458 motile cilium assembly(GO:0044458)
0.0 0.2 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.0 0.3 GO:0072189 ureter development(GO:0072189)
0.0 0.1 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.0 0.2 GO:0071280 cellular response to copper ion(GO:0071280)
0.0 0.0 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0 0.5 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.2 GO:0007343 egg activation(GO:0007343)
0.0 1.1 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.0 0.1 GO:0046116 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.0 0.5 GO:0002011 morphogenesis of an epithelial sheet(GO:0002011)
0.0 0.2 GO:0015705 thyroid hormone generation(GO:0006590) iodide transport(GO:0015705)
0.0 0.2 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.0 1.6 GO:0030216 keratinocyte differentiation(GO:0030216)
0.0 0.1 GO:0043470 regulation of carbohydrate catabolic process(GO:0043470) regulation of cellular carbohydrate catabolic process(GO:0043471)
0.0 0.2 GO:0002051 osteoblast fate commitment(GO:0002051)
0.0 0.1 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.0 2.5 GO:0007596 blood coagulation(GO:0007596)
0.0 0.2 GO:0048757 endosome to melanosome transport(GO:0035646) endosome to pigment granule transport(GO:0043485) pigment granule maturation(GO:0048757)
0.0 0.1 GO:0015889 cobalamin transport(GO:0015889)
0.0 0.4 GO:0044062 regulation of excretion(GO:0044062)
0.0 0.1 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.0 0.5 GO:0007588 excretion(GO:0007588)
0.0 0.2 GO:0086069 bundle of His cell to Purkinje myocyte communication(GO:0086069)
0.0 0.2 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.2 GO:0031069 hair follicle morphogenesis(GO:0031069)
0.0 0.2 GO:0016188 synaptic vesicle maturation(GO:0016188)
0.0 1.9 GO:0042060 wound healing(GO:0042060)
0.0 1.0 GO:0007006 mitochondrial membrane organization(GO:0007006)
0.0 0.2 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.0 0.7 GO:0051591 response to cAMP(GO:0051591)
0.0 0.1 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.0 1.0 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 1.4 GO:0051028 mRNA transport(GO:0051028)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.7 37.1 GO:0005579 membrane attack complex(GO:0005579)
0.5 4.1 GO:0045098 type III intermediate filament(GO:0045098)
0.5 3.5 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.3 2.1 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.3 3.1 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.3 0.9 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
0.3 5.8 GO:0005922 connexon complex(GO:0005922)
0.2 0.7 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.2 8.9 GO:0005771 multivesicular body(GO:0005771)
0.2 0.7 GO:0044218 other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
0.2 1.7 GO:1990357 terminal web(GO:1990357)
0.2 0.3 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.2 4.4 GO:0000930 gamma-tubulin complex(GO:0000930)
0.2 1.3 GO:0033269 internode region of axon(GO:0033269)
0.1 0.9 GO:0031211 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.1 2.2 GO:0031143 pseudopodium(GO:0031143)
0.1 2.5 GO:0045095 keratin filament(GO:0045095)
0.1 0.6 GO:0001940 male pronucleus(GO:0001940)
0.1 1.2 GO:0071564 npBAF complex(GO:0071564)
0.1 0.2 GO:0016939 kinesin II complex(GO:0016939)
0.1 0.4 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.1 0.5 GO:0030991 intraciliary transport particle A(GO:0030991)
0.1 0.8 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 0.5 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.0 0.8 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.3 GO:0001652 granular component(GO:0001652)
0.0 0.2 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
0.0 0.5 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 2.0 GO:0015030 Cajal body(GO:0015030)
0.0 0.8 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 1.0 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.9 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.4 GO:0005921 gap junction(GO:0005921)
0.0 0.5 GO:0044292 dendrite terminus(GO:0044292)
0.0 3.6 GO:0005902 microvillus(GO:0005902)
0.0 0.2 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 1.1 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 0.4 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.4 GO:0032426 stereocilium tip(GO:0032426)
0.0 1.1 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 1.0 GO:0001772 immunological synapse(GO:0001772)
0.0 18.8 GO:0009986 cell surface(GO:0009986)
0.0 0.9 GO:0045171 intercellular bridge(GO:0045171)
0.0 0.1 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.7 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 1.2 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.6 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.2 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.2 GO:0000159 protein phosphatase type 2A complex(GO:0000159)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.3 GO:0045352 interleukin-1, Type II receptor binding(GO:0005151) interleukin-1 receptor antagonist activity(GO:0005152) interleukin-1 Type I receptor antagonist activity(GO:0045352) interleukin-1 Type II receptor antagonist activity(GO:0045353)
1.3 5.0 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
1.0 6.7 GO:0004556 alpha-amylase activity(GO:0004556)
0.8 4.1 GO:0004850 uridine phosphorylase activity(GO:0004850)
0.7 5.0 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.7 3.5 GO:0004925 prolactin receptor activity(GO:0004925)
0.7 3.3 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.6 2.3 GO:0008859 exoribonuclease II activity(GO:0008859)
0.6 3.9 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.5 2.2 GO:0015057 thrombin receptor activity(GO:0015057)
0.4 1.8 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.4 1.1 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.3 1.0 GO:0005118 sevenless binding(GO:0005118)
0.3 3.6 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.2 0.7 GO:0019981 interleukin-6 receptor activity(GO:0004915) leukemia inhibitory factor receptor activity(GO:0004923) interleukin-6 binding(GO:0019981)
0.2 0.9 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.2 7.7 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.2 0.7 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.2 0.9 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.2 5.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.2 1.6 GO:0071253 connexin binding(GO:0071253)
0.2 0.8 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.2 2.8 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.2 4.0 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.2 2.9 GO:0005243 gap junction channel activity(GO:0005243)
0.2 0.5 GO:0035651 AP-3 adaptor complex binding(GO:0035651)
0.1 1.0 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 0.8 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.1 4.4 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 1.2 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 0.4 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.1 11.3 GO:0005179 hormone activity(GO:0005179)
0.1 0.6 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.1 0.5 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.1 0.3 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.1 3.0 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.1 0.5 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.1 0.5 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.1 1.4 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.1 0.3 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.1 0.5 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 2.1 GO:0005521 lamin binding(GO:0005521)
0.1 1.1 GO:0015194 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.1 10.3 GO:0005178 integrin binding(GO:0005178)
0.1 1.5 GO:0035497 cAMP response element binding(GO:0035497)
0.1 0.8 GO:0070008 serine-type exopeptidase activity(GO:0070008)
0.1 0.2 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.1 0.8 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.3 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.1 1.9 GO:0042056 chemoattractant activity(GO:0042056)
0.1 0.5 GO:0005534 galactose binding(GO:0005534)
0.1 0.3 GO:0003884 D-amino-acid oxidase activity(GO:0003884)
0.1 0.8 GO:0008417 fucosyltransferase activity(GO:0008417)
0.1 0.2 GO:0004947 bradykinin receptor activity(GO:0004947)
0.1 1.3 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 2.7 GO:0070888 E-box binding(GO:0070888)
0.0 0.6 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.3 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 1.4 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.3 GO:0033142 progesterone receptor binding(GO:0033142)
0.0 1.3 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.2 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.0 0.9 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.2 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.0 0.2 GO:0005350 purine nucleobase transmembrane transporter activity(GO:0005345) pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205) glycerol channel activity(GO:0015254)
0.0 0.9 GO:0017081 chloride channel regulator activity(GO:0017081)
0.0 1.8 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.2 GO:0031013 troponin I binding(GO:0031013)
0.0 0.2 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 1.6 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.4 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.4 GO:0019865 immunoglobulin binding(GO:0019865)
0.0 1.5 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.1 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.0 0.2 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 1.3 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.3 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.0 1.2 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.8 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 1.4 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 1.0 GO:0005109 frizzled binding(GO:0005109)
0.0 0.2 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 28.5 GO:0032403 protein complex binding(GO:0032403)
0.0 0.2 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.0 0.7 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 2.1 GO:0008201 heparin binding(GO:0008201)
0.0 0.4 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.2 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.8 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 0.7 GO:0050699 WW domain binding(GO:0050699)
0.0 0.4 GO:0051393 alpha-actinin binding(GO:0051393)
0.0 0.2 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.3 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.0 0.1 GO:0032036 myosin heavy chain binding(GO:0032036)
0.0 0.1 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.2 GO:0004629 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.0 0.1 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 0.1 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0 0.2 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 20.1 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 7.9 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 5.6 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.1 3.3 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.1 6.0 PID IL1 PATHWAY IL1-mediated signaling events
0.1 2.2 ST GA12 PATHWAY G alpha 12 Pathway
0.1 2.9 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 3.5 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.1 0.4 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.1 1.9 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.0 0.9 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.8 PID IGF1 PATHWAY IGF1 pathway
0.0 0.7 PID IL27 PATHWAY IL27-mediated signaling events
0.0 0.8 PID GMCSF PATHWAY GMCSF-mediated signaling events
0.0 0.6 PID NECTIN PATHWAY Nectin adhesion pathway
0.0 2.2 PID AP1 PATHWAY AP-1 transcription factor network
0.0 0.8 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 1.0 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 1.3 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.5 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 0.6 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 0.4 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 1.6 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.9 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.0 1.4 PID P53 REGULATION PATHWAY p53 pathway
0.0 0.8 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.7 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.0 PID FGF PATHWAY FGF signaling pathway
0.0 0.8 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.7 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.2 PID ERBB4 PATHWAY ErbB4 signaling events
0.0 0.3 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 0.2 PID ALK2 PATHWAY ALK2 signaling events
0.0 0.3 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.4 PID CXCR3 PATHWAY CXCR3-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 35.9 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.7 11.8 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.3 5.5 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.2 4.1 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.2 3.5 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.2 1.9 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.2 2.0 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.1 4.8 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 0.8 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.1 0.8 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 4.0 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.1 3.5 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 0.7 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.1 2.8 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 1.2 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.1 1.5 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.1 3.4 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.7 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.8 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 1.6 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 2.3 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 1.9 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 1.7 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 1.2 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.7 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 1.0 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.4 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.7 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.8 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0 2.2 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.0 0.4 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.2 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 4.8 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.4 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.9 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.9 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.6 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.1 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.5 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 0.4 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 1.4 REACTOME DIABETES PATHWAYS Genes involved in Diabetes pathways
0.0 3.7 REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION Genes involved in Class I MHC mediated antigen processing & presentation
0.0 0.6 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 0.6 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 2.3 REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.0 0.1 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis