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12D miR HR13_24

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Results for Prox1

Z-value: 0.41

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Transcription factors associated with Prox1

Gene Symbol Gene ID Gene Info
ENSMUSG00000010175.7 prospero homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Prox1mm10_v2_chr1_-_190169399_190169526-0.767.2e-03Click!

Activity profile of Prox1 motif

Sorted Z-values of Prox1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr14_-_51146757 0.50 ENSMUST00000080126.2
ribonuclease, RNase A family, 1 (pancreatic)
chr17_-_34959232 0.48 ENSMUST00000165202.1
ENSMUST00000172753.1
heat shock protein 1B
chr17_-_34972124 0.40 ENSMUST00000087328.2
ENSMUST00000179128.1
heat shock protein 1A
chr7_-_101868667 0.39 ENSMUST00000150184.1
folate receptor 1 (adult)
chr8_-_3467617 0.30 ENSMUST00000111081.3
ENSMUST00000118194.1
ENSMUST00000004686.6
peroxisomal biogenesis factor 11 gamma
chr4_-_137430517 0.30 ENSMUST00000102522.4
chymotrypsin-like elastase family, member 3B
chr7_-_127448993 0.29 ENSMUST00000106299.1
zinc finger protein 689
chr8_+_60632856 0.27 ENSMUST00000160719.1
microfibrillar-associated protein 3-like
chr5_+_124112297 0.25 ENSMUST00000024470.6
ENSMUST00000119269.1
2-oxoglutarate and iron-dependent oxygenase domain containing 2
chr8_+_60632818 0.24 ENSMUST00000161421.1
microfibrillar-associated protein 3-like
chr4_-_137409777 0.23 ENSMUST00000024200.6
predicted gene 13011
chr17_+_86963279 0.21 ENSMUST00000139344.1
ras homolog gene family, member Q
chr8_+_99416585 0.20 ENSMUST00000064349.5
RIKEN cDNA A330008L17 gene
chr8_-_99416397 0.20 ENSMUST00000155527.1
ENSMUST00000142129.1
ENSMUST00000093249.4
ENSMUST00000142475.2
ENSMUST00000128860.1
cadherin 8
chr9_+_104569671 0.19 ENSMUST00000057742.8
copine IV
chr6_-_42373254 0.18 ENSMUST00000073387.2
Eph receptor A1
chr15_-_80014808 0.18 ENSMUST00000000500.6
platelet derived growth factor, B polypeptide
chr8_+_31111816 0.17 ENSMUST00000046941.7
ring finger protein 122
chr1_-_169747634 0.17 ENSMUST00000027991.5
ENSMUST00000111357.1
regulator of G-protein signaling 4
chr10_-_41611319 0.16 ENSMUST00000179614.1
coiled-coil domain containing 162
chr18_-_67245818 0.16 ENSMUST00000073054.3
metallophosphoesterase 1
chr17_+_37045980 0.16 ENSMUST00000174456.1
gamma-aminobutyric acid (GABA) B receptor, 1
chr7_-_127449109 0.16 ENSMUST00000053392.4
zinc finger protein 689
chr1_+_87796467 0.15 ENSMUST00000097661.3
RIKEN cDNA 5830472F04 gene
chr11_-_115612878 0.14 ENSMUST00000106506.1
MIF4G domain containing
chr4_+_99829437 0.14 ENSMUST00000124547.1
ENSMUST00000106994.1
EF-hand calcium binding domain 7
chr3_+_20057802 0.13 ENSMUST00000002502.5
helicase-like transcription factor
chr6_+_122308684 0.13 ENSMUST00000007602.8
ENSMUST00000112610.1
mannose-6-phosphate receptor, cation dependent
chr11_-_115612940 0.13 ENSMUST00000021087.7
MIF4G domain containing
chr5_+_139252343 0.13 ENSMUST00000130326.1
golgi to ER traffic protein 4 homolog (S. cerevisiae)
chr3_-_121283096 0.13 ENSMUST00000135818.1
ENSMUST00000137234.1
transmembrane protein 56
chr5_-_37824580 0.13 ENSMUST00000063116.9
msh homeobox 1
chr19_+_46152505 0.13 ENSMUST00000026254.7
golgi-specific brefeldin A-resistance factor 1
chr4_+_130913264 0.12 ENSMUST00000156225.1
ENSMUST00000156742.1
lysosomal-associated protein transmembrane 5
chr5_+_139252314 0.11 ENSMUST00000026976.5
golgi to ER traffic protein 4 homolog (S. cerevisiae)
chr17_-_70924958 0.11 ENSMUST00000180468.1
predicted gene, 26510
chr7_+_24081888 0.11 ENSMUST00000068975.3
zinc finger protein 180
chr13_+_9276477 0.10 ENSMUST00000174552.1
DIP2 disco-interacting protein 2 homolog C (Drosophila)
chr12_+_111442453 0.10 ENSMUST00000102745.3
tumor necrosis factor, alpha-induced protein 2
chr12_+_111442653 0.09 ENSMUST00000109792.1
tumor necrosis factor, alpha-induced protein 2
chr1_+_78816909 0.09 ENSMUST00000057262.6
potassium voltage-gated channel, Isk-related subfamily, gene 4
chr4_+_74242468 0.09 ENSMUST00000077851.3
lysine (K)-specific demethylase 4C
chr1_+_161395409 0.08 ENSMUST00000028024.4
tumor necrosis factor (ligand) superfamily, member 4
chr2_+_27009926 0.08 ENSMUST00000114005.2
ENSMUST00000114004.1
ENSMUST00000114006.1
ENSMUST00000114007.1
calcium channel flower domain containing 1
chr14_-_55944536 0.08 ENSMUST00000022834.6
chymase 1, mast cell
chr3_-_89402650 0.08 ENSMUST00000168325.1
ENSMUST00000057431.5
lens epithelial protein
chr15_-_86186136 0.08 ENSMUST00000044332.9
ceramide kinase
chr5_+_53998417 0.07 ENSMUST00000117661.2
ENSMUST00000071083.7
stromal interaction molecule 2
chr12_-_40223149 0.07 ENSMUST00000171553.1
ENSMUST00000001672.5
interferon-related developmental regulator 1
chr12_-_36042476 0.07 ENSMUST00000020896.8
tetraspanin 13
chr2_+_34406845 0.07 ENSMUST00000124443.1
ENSMUST00000113124.1
mitogen-activated protein kinase associated protein 1
chr4_-_36951223 0.07 ENSMUST00000108122.1
leucine rich repeat and Ig domain containing 2
chr2_-_167062981 0.06 ENSMUST00000048988.7
zinc finger, NFX1-type containing 1
chr2_+_34406882 0.06 ENSMUST00000113123.1
mitogen-activated protein kinase associated protein 1
chr11_+_19924354 0.06 ENSMUST00000093299.6
sprouty-related, EVH1 domain containing 2
chr1_-_135981941 0.06 ENSMUST00000124134.1
immunoglobulin-like and fibronectin type III domain containing 1
chr9_-_64726583 0.06 ENSMUST00000168366.1
RAB11a, member RAS oncogene family
chr17_+_37045963 0.06 ENSMUST00000025338.9
gamma-aminobutyric acid (GABA) B receptor, 1
chr15_+_102990576 0.06 ENSMUST00000001703.6
homeobox C8
chr18_+_46850034 0.06 ENSMUST00000025358.2
RIKEN cDNA 4833403I15 gene
chr12_+_40222758 0.05 ENSMUST00000038121.4
predicted gene 7008
chr2_+_34406949 0.05 ENSMUST00000040459.4
mitogen-activated protein kinase associated protein 1
chr2_-_136891363 0.05 ENSMUST00000028730.6
ENSMUST00000110089.2
McKusick-Kaufman syndrome
chr4_-_94556737 0.05 ENSMUST00000030313.8
caspase activity and apoptosis inhibitor 1
chr11_+_4986824 0.05 ENSMUST00000009234.9
ENSMUST00000109897.1
adaptor protein complex AP-1, beta 1 subunit
chr14_-_96519067 0.04 ENSMUST00000022666.7
kelch-like 1
chr17_-_37280418 0.04 ENSMUST00000077585.2
olfactory receptor 99
chr7_+_28716846 0.04 ENSMUST00000108279.2
F-box protein 17
chr7_-_80947499 0.04 ENSMUST00000120285.1
SEC11 homolog A (S. cerevisiae)
chr2_-_168734236 0.02 ENSMUST00000109175.2
ATPase, class II, type 9A
chr12_-_83487708 0.02 ENSMUST00000177959.1
ENSMUST00000178756.1
D4, zinc and double PHD fingers, family 3
chr2_+_36230426 0.02 ENSMUST00000062069.5
prostaglandin-endoperoxide synthase 1
chr2_-_136891131 0.02 ENSMUST00000144275.1
McKusick-Kaufman syndrome
chr7_+_28716777 0.02 ENSMUST00000032818.6
ENSMUST00000108278.2
F-box protein 17
chr9_+_118478182 0.02 ENSMUST00000111763.1
eomesodermin homolog (Xenopus laevis)
chr11_+_72207537 0.01 ENSMUST00000021158.3
thioredoxin domain containing 17
chr10_-_81025521 0.01 ENSMUST00000144640.1
DIRAS family, GTP-binding RAS-like 1
chr4_+_117835387 0.01 ENSMUST00000169885.1
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr17_+_24426676 0.01 ENSMUST00000024946.5
enoyl-Coenzyme A delta isomerase 1
chr5_-_138187177 0.00 ENSMUST00000110937.1
ENSMUST00000139276.1
ENSMUST00000048698.7
ENSMUST00000123415.1
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr11_+_19924403 0.00 ENSMUST00000093298.5
sprouty-related, EVH1 domain containing 2

Network of associatons between targets according to the STRING database.

First level regulatory network of Prox1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:1900239 negative regulation of phosphatidylinositol biosynthetic process(GO:0010512) regulation of phenotypic switching(GO:1900239)
0.0 0.3 GO:0044375 regulation of peroxisome size(GO:0044375)
0.0 0.1 GO:0035964 COPI-coated vesicle budding(GO:0035964) protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0 0.4 GO:0003147 neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713) cellular response to folic acid(GO:0071231)
0.0 0.1 GO:0090427 activation of meiosis(GO:0090427)
0.0 0.2 GO:0014053 negative regulation of gamma-aminobutyric acid secretion(GO:0014053)
0.0 0.2 GO:0071816 maintenance of unfolded protein(GO:0036506) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.0 0.1 GO:0043382 defense response to nematode(GO:0002215) memory T cell activation(GO:0035709) positive regulation of memory T cell differentiation(GO:0043382) negative regulation of T-helper 1 cell differentiation(GO:0045626) positive regulation of isotype switching to IgE isotypes(GO:0048295) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
0.0 0.2 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0 0.1 GO:0042222 interleukin-1 biosynthetic process(GO:0042222)
0.0 0.1 GO:0038108 negative regulation of appetite by leptin-mediated signaling pathway(GO:0038108)
0.0 0.1 GO:0032237 activation of store-operated calcium channel activity(GO:0032237)
0.0 0.5 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.0 0.1 GO:0010796 regulation of multivesicular body size(GO:0010796)
0.0 0.2 GO:0051601 exocyst localization(GO:0051601)
0.0 0.1 GO:0033299 secretion of lysosomal enzymes(GO:0033299)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.0 0.2 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0 0.5 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.0 0.1 GO:1902636 kinociliary basal body(GO:1902636)
0.0 0.4 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.2 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.2 GO:0031932 TORC2 complex(GO:0031932)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.1 0.4 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.0 0.2 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.4 GO:0051870 methotrexate binding(GO:0051870)
0.0 0.2 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.1 GO:0001729 ceramide kinase activity(GO:0001729)
0.0 0.2 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.2 GO:0005522 profilin binding(GO:0005522)
0.0 0.3 GO:0031418 L-ascorbic acid binding(GO:0031418)
0.0 0.1 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.0 0.3 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.1 GO:0005173 stem cell factor receptor binding(GO:0005173)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.1 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport