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12D miR HR13_24

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Results for Nfkb2

Z-value: 0.51

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Transcription factors associated with Nfkb2

Gene Symbol Gene ID Gene Info
ENSMUSG00000025225.8 nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nfkb2mm10_v2_chr19_+_46304709_463048110.235.0e-01Click!

Activity profile of Nfkb2 motif

Sorted Z-values of Nfkb2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_29289300 1.51 ENSMUST00000048187.4
protein phosphatase 1, regulatory (inhibitor) subunit 14A
chr2_-_32312162 1.19 ENSMUST00000155269.1
dynamin 1
chr9_+_55326913 1.15 ENSMUST00000085754.3
ENSMUST00000034862.4
expressed sequence AI118078
chr19_+_7268296 0.97 ENSMUST00000066646.4
REST corepressor 2
chr15_-_101562889 0.83 ENSMUST00000023714.4
RIKEN cDNA 4732456N10 gene
chr2_-_102451792 0.75 ENSMUST00000099678.3
four jointed box 1 (Drosophila)
chr1_+_34801704 0.64 ENSMUST00000047664.9
Rho guanine nucleotide exchange factor (GEF) 4
chr9_-_44735189 0.54 ENSMUST00000034611.8
pleckstrin homology-like domain, family B, member 1
chr18_-_77565050 0.47 ENSMUST00000182153.1
ENSMUST00000182146.1
ENSMUST00000026494.7
ENSMUST00000182024.1
ring finger protein 165
chr8_+_120002720 0.47 ENSMUST00000108972.3
cysteine-rich secretory protein LCCL domain containing 2
chr16_+_32914094 0.43 ENSMUST00000023491.6
ENSMUST00000170899.1
ENSMUST00000171118.1
ENSMUST00000170201.1
ENSMUST00000165616.1
ENSMUST00000135193.2
leucine-rich repeats and calponin homology (CH) domain containing 3
chr7_+_16309577 0.42 ENSMUST00000002152.6
BCL2 binding component 3
chr7_-_126200413 0.42 ENSMUST00000163959.1
exportin 6
chr2_-_164473714 0.42 ENSMUST00000017864.2
transformation related protein 53 target 5
chr5_+_37245792 0.40 ENSMUST00000031004.7
collapsin response mediator protein 1
chr5_+_110544326 0.39 ENSMUST00000040001.7
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9
chr7_-_126200474 0.39 ENSMUST00000168189.1
exportin 6
chr11_+_70029742 0.39 ENSMUST00000132597.2
discs, large homolog 4 (Drosophila)
chr1_+_74791516 0.37 ENSMUST00000006718.8
wingless related MMTV integration site 10a
chr8_+_79028587 0.34 ENSMUST00000119254.1
zinc finger protein 827
chr19_-_46338632 0.32 ENSMUST00000051234.8
ENSMUST00000167861.1
CUE domain containing 2
chr11_-_70015346 0.32 ENSMUST00000018718.7
ENSMUST00000102574.3
acyl-Coenzyme A dehydrogenase, very long chain
chr11_+_77686155 0.31 ENSMUST00000100802.4
ENSMUST00000181023.1
nuclear fragile X mental retardation protein interacting protein 2
chr7_-_126200397 0.31 ENSMUST00000009344.9
exportin 6
chr14_-_55591077 0.29 ENSMUST00000161807.1
ENSMUST00000111378.3
ENSMUST00000159687.1
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr17_+_35506018 0.28 ENSMUST00000025271.10
POU domain, class 5, transcription factor 1
chr8_-_104631312 0.27 ENSMUST00000034351.6
Ras-related associated with diabetes
chr11_-_33147400 0.27 ENSMUST00000020507.7
fibroblast growth factor 18
chr9_+_5308828 0.26 ENSMUST00000162846.1
ENSMUST00000027012.7
caspase 4, apoptosis-related cysteine peptidase
chr11_-_70656467 0.24 ENSMUST00000131642.1
predicted gene 12319
chr8_+_79028317 0.24 ENSMUST00000087927.4
ENSMUST00000098614.2
zinc finger protein 827
chr4_+_129985098 0.23 ENSMUST00000106017.1
ENSMUST00000121049.1
brain-specific angiogenesis inhibitor 2
chr15_-_76918010 0.22 ENSMUST00000048854.7
zinc finger protein 647
chr2_+_10153563 0.22 ENSMUST00000026886.7
inter-alpha (globulin) inhibitor H5
chr1_+_153740344 0.21 ENSMUST00000027748.7
regulator of G-protein signaling 16
chr7_+_19176416 0.21 ENSMUST00000117338.1
echinoderm microtubule associated protein like 2
chr4_+_129984833 0.19 ENSMUST00000120204.1
brain-specific angiogenesis inhibitor 2
chr10_-_59221757 0.18 ENSMUST00000165971.1
septin 10
chr7_-_101302020 0.17 ENSMUST00000122116.1
ENSMUST00000120267.1
autophagy related 16-like 2 (S. cerevisiae)
chr17_-_35205305 0.16 ENSMUST00000025266.5
lymphotoxin A
chr13_-_111490028 0.15 ENSMUST00000091236.4
GC-rich promoter binding protein 1
chrX_-_7671341 0.15 ENSMUST00000033486.5
proteolipid protein 2
chr3_+_97658212 0.14 ENSMUST00000045743.6
protein kinase, AMP-activated, beta 2 non-catalytic subunit
chr8_-_105289465 0.13 ENSMUST00000171788.1
ENSMUST00000014981.6
RIKEN cDNA 4931428F04 gene
chr5_+_125475814 0.12 ENSMUST00000031445.3
acetoacetyl-CoA synthetase
chr9_-_107609182 0.12 ENSMUST00000102531.1
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr9_-_107609215 0.11 ENSMUST00000102532.3
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr11_-_68386974 0.10 ENSMUST00000135141.1
netrin 1
chrX_+_163908982 0.09 ENSMUST00000069041.8
adaptor-related protein complex 1, sigma 2 subunit
chr11_+_101176041 0.09 ENSMUST00000103109.3
contactin associated protein-like 1
chr7_+_30422389 0.08 ENSMUST00000108175.1
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, delta
chr2_-_37422869 0.07 ENSMUST00000112936.1
ENSMUST00000112934.1
ring finger and CCCH-type zinc finger domains 2
chr10_+_127421208 0.07 ENSMUST00000168780.1
R3H domain containing 2
chr13_-_111490111 0.07 ENSMUST00000047627.7
GC-rich promoter binding protein 1
chr13_+_43785107 0.06 ENSMUST00000015540.2
CD83 antigen
chr10_-_89686250 0.05 ENSMUST00000092227.5
ENSMUST00000174252.1
SCY1-like 2 (S. cerevisiae)
chr17_-_35980197 0.05 ENSMUST00000055454.7
proline-rich polypeptide 3
chr17_+_34898931 0.04 ENSMUST00000097342.3
ENSMUST00000013931.5
euchromatic histone lysine N-methyltransferase 2
chr19_+_45015198 0.04 ENSMUST00000179108.1
leucine zipper, putative tumor suppressor 2
chr5_+_90891234 0.04 ENSMUST00000031327.8
chemokine (C-X-C motif) ligand 1
chr1_-_152902628 0.04 ENSMUST00000111836.2
ENSMUST00000073441.6
Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
chr11_-_68386821 0.03 ENSMUST00000021284.3
netrin 1
chr11_-_84870812 0.03 ENSMUST00000168434.1
gametogenetin binding protein 2
chr2_-_160313616 0.02 ENSMUST00000109475.2
predicted gene 826
chr11_-_84870712 0.01 ENSMUST00000170741.1
ENSMUST00000172405.1
ENSMUST00000100686.3
ENSMUST00000108081.2
gametogenetin binding protein 2
chr1_-_155742120 0.01 ENSMUST00000027740.7
LIM homeobox protein 4
chr5_-_137530990 0.00 ENSMUST00000132525.1
guanine nucleotide binding protein (G protein), beta 2

Network of associatons between targets according to the STRING database.

First level regulatory network of Nfkb2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.1 0.4 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.1 0.4 GO:1904616 regulation of actin filament binding(GO:1904529) regulation of actin binding(GO:1904616)
0.1 0.3 GO:0001712 ectodermal cell fate commitment(GO:0001712) regulation of heart induction by regulation of canonical Wnt signaling pathway(GO:0090081)
0.1 0.3 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.1 0.3 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.1 0.2 GO:0002874 regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
0.1 0.3 GO:1904849 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.0 0.5 GO:1904259 regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
0.0 0.3 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.0 0.3 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.0 0.4 GO:0099628 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
0.0 0.2 GO:0010968 regulation of microtubule nucleation(GO:0010968)
0.0 0.2 GO:0044034 negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
0.0 0.7 GO:0010842 retina layer formation(GO:0010842)
0.0 1.6 GO:0035690 cellular response to drug(GO:0035690)
0.0 0.4 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.0 0.1 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.0 0.1 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.0 0.5 GO:0060384 innervation(GO:0060384)
0.0 0.0 GO:0070947 neutrophil mediated killing of fungus(GO:0070947)
0.0 1.1 GO:0006611 protein export from nucleus(GO:0006611)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.1 1.2 GO:0043196 varicosity(GO:0043196)
0.0 0.5 GO:0045180 basal cortex(GO:0045180)
0.0 0.3 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.4 GO:0044300 juxtaparanode region of axon(GO:0044224) cerebellar mossy fiber(GO:0044300)
0.0 0.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 1.3 GO:0017053 transcriptional repressor complex(GO:0017053)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.1 0.3 GO:0017099 very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099)
0.1 0.3 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 0.4 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.0 0.3 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 1.5 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.3 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.0 1.1 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.3 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.6 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.4 GO:0031005 filamin binding(GO:0031005)
0.0 0.2 GO:0038191 neuropilin binding(GO:0038191)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 1.5 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 0.4 ST GA12 PATHWAY G alpha 12 Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.4 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.3 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.3 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 0.4 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.1 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling