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12D miR HR13_24

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Results for E2f8

Z-value: 1.26

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Transcription factors associated with E2f8

Gene Symbol Gene ID Gene Info
ENSMUSG00000046179.11 E2F transcription factor 8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
E2f8mm10_v2_chr7_-_48881596_488816190.927.8e-05Click!

Activity profile of E2f8 motif

Sorted Z-values of E2f8 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr8_+_75109528 3.43 ENSMUST00000164309.1
minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
chr5_+_123749696 3.12 ENSMUST00000031366.7
kinetochore associated 1
chr16_-_18811615 2.90 ENSMUST00000096990.3
cell division cycle 45
chr17_+_56040350 2.55 ENSMUST00000002914.8
chromatin assembly factor 1, subunit A (p150)
chr17_+_56303321 2.47 ENSMUST00000001258.8
ubiquitin-like, containing PHD and RING finger domains, 1
chr7_-_48881596 2.11 ENSMUST00000119223.1
E2F transcription factor 8
chr1_-_128359610 2.08 ENSMUST00000027601.4
minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)
chr7_-_48881032 2.07 ENSMUST00000058745.8
E2F transcription factor 8
chr17_+_56303396 2.05 ENSMUST00000113038.1
ubiquitin-like, containing PHD and RING finger domains, 1
chr12_+_24708984 1.86 ENSMUST00000154588.1
ribonucleotide reductase M2
chr19_+_38931008 1.83 ENSMUST00000145051.1
helicase, lymphoid specific
chr3_+_126363827 1.82 ENSMUST00000093976.2
arylsulfatase J
chrX_+_49470450 1.77 ENSMUST00000114904.3
Rho GTPase activating protein 36
chrX_+_49470555 1.77 ENSMUST00000042444.6
Rho GTPase activating protein 36
chr10_+_128015157 1.77 ENSMUST00000178041.1
ENSMUST00000026461.7
DNA primase, p49 subunit
chr19_+_38930909 1.76 ENSMUST00000025965.5
helicase, lymphoid specific
chr11_+_98907801 1.66 ENSMUST00000092706.6
cell division cycle 6
chr13_+_19623163 1.62 ENSMUST00000002883.5
secreted frizzled-related protein 4
chr6_+_21215472 1.61 ENSMUST00000081542.5
potassium voltage-gated channel, Shal-related family, member 2
chr7_-_44548733 1.57 ENSMUST00000145956.1
ENSMUST00000049343.8
polymerase (DNA directed), delta 1, catalytic subunit
chr2_-_34913976 1.57 ENSMUST00000028232.3
PHD finger protein 19
chr12_+_24708241 1.53 ENSMUST00000020980.5
ribonucleotide reductase M2
chr6_+_35177386 1.52 ENSMUST00000043815.9
nucleoporin 205
chr6_-_88898664 1.50 ENSMUST00000058011.6
minichromosome maintenance deficient 2 mitotin (S. cerevisiae)
chr9_-_35116804 1.43 ENSMUST00000034537.6
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
chr9_-_36726374 1.37 ENSMUST00000172702.2
ENSMUST00000172742.1
ENSMUST00000034625.5
checkpoint kinase 1
chr4_+_132768325 1.30 ENSMUST00000102561.4
replication protein A2
chr6_+_35177610 1.20 ENSMUST00000170234.1
nucleoporin 205
chr2_+_163054682 1.19 ENSMUST00000018005.3
myeloblastosis oncogene-like 2
chr16_+_10835046 1.18 ENSMUST00000037913.8
RMI2, RecQ mediated genome instability 2, homolog (S. cerevisiae)
chr16_+_20733104 1.18 ENSMUST00000115423.1
ENSMUST00000007171.6
chordin
chr9_+_103305156 1.13 ENSMUST00000035164.3
topoisomerase (DNA) II binding protein 1
chr6_-_125286015 0.97 ENSMUST00000088246.5
tubulin, alpha 3A
chr6_+_117916981 0.95 ENSMUST00000179478.1
heterogeneous nuclear ribonucleoprotein F
chr16_-_15637277 0.92 ENSMUST00000023353.3
minichromosome maintenance deficient 4 homolog (S. cerevisiae)
chr6_+_117917281 0.87 ENSMUST00000180020.1
ENSMUST00000177570.1
heterogeneous nuclear ribonucleoprotein F
chr5_-_33652339 0.80 ENSMUST00000075670.6
stem-loop binding protein
chr2_-_45112890 0.74 ENSMUST00000076836.6
zinc finger E-box binding homeobox 2
chr15_+_55557399 0.72 ENSMUST00000022998.7
Mdm2, transformed 3T3 cell double minute p53 binding protein
chr2_+_24949747 0.69 ENSMUST00000028350.3
zinc finger, MYND domain containing 19
chr13_+_44731265 0.63 ENSMUST00000173246.1
jumonji, AT rich interactive domain 2
chr5_-_33652296 0.59 ENSMUST00000151081.1
ENSMUST00000101354.3
stem-loop binding protein
chr6_-_94700137 0.51 ENSMUST00000101126.2
ENSMUST00000032105.4
leucine-rich repeats and immunoglobulin-like domains 1
chr10_-_21160925 0.49 ENSMUST00000020158.6
myeloblastosis oncogene
chr5_-_65335564 0.48 ENSMUST00000172780.1
replication factor C (activator 1) 1
chr2_-_45113255 0.47 ENSMUST00000068415.4
ENSMUST00000127520.1
zinc finger E-box binding homeobox 2
chr4_-_129189600 0.45 ENSMUST00000117497.1
ENSMUST00000117350.1
S100P binding protein
chr15_-_55557748 0.45 ENSMUST00000172387.1
mitochondrial ribosomal protein L13
chr7_+_102065713 0.44 ENSMUST00000094129.2
ENSMUST00000094130.2
ENSMUST00000084843.3
transient receptor potential cation channel, subfamily C, member 2
chr10_+_42860543 0.43 ENSMUST00000157071.1
sex comb on midleg-like 4 (Drosophila)
chr5_-_65335597 0.43 ENSMUST00000172660.1
ENSMUST00000172732.1
ENSMUST00000031092.8
replication factor C (activator 1) 1
chr9_-_50659780 0.43 ENSMUST00000034567.3
dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)
chr4_-_129189646 0.40 ENSMUST00000106059.1
S100P binding protein
chr5_+_150673739 0.40 ENSMUST00000016569.4
ENSMUST00000038900.8
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr15_+_55557575 0.39 ENSMUST00000170046.1
Mdm2, transformed 3T3 cell double minute p53 binding protein
chr4_-_129189512 0.38 ENSMUST00000117965.1
ENSMUST00000106061.2
ENSMUST00000072431.6
S100P binding protein
chr5_+_137787769 0.35 ENSMUST00000035852.7
zinc finger, CW type with PWWP domain 1
chr7_+_102065485 0.32 ENSMUST00000106950.1
ENSMUST00000146450.1
transient receptor potential cation channel, subfamily C, member 2
chr1_+_131910458 0.29 ENSMUST00000062264.6
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr6_-_87851011 0.29 ENSMUST00000113617.1
cellular nucleic acid binding protein
chr11_+_88047302 0.28 ENSMUST00000139129.2
serine/arginine-rich splicing factor 1
chr2_-_154569845 0.25 ENSMUST00000103145.4
E2F transcription factor 1
chr16_-_18248697 0.22 ENSMUST00000115645.3
RAN binding protein 1
chr13_+_44731281 0.22 ENSMUST00000174086.1
jumonji, AT rich interactive domain 2
chr11_+_88047693 0.20 ENSMUST00000079866.4
serine/arginine-rich splicing factor 1
chr3_-_127553233 0.16 ENSMUST00000029588.5
La ribonucleoprotein domain family, member 7
chr17_-_35235755 0.16 ENSMUST00000048994.6
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor like 1
chr11_+_79993062 0.15 ENSMUST00000017692.8
ENSMUST00000163272.1
suppressor of zeste 12 homolog (Drosophila)
chr17_+_34377124 0.13 ENSMUST00000080254.5
butyrophilin-like 1
chr11_-_101785252 0.13 ENSMUST00000164750.1
ENSMUST00000107176.1
ENSMUST00000017868.6
ets variant gene 4 (E1A enhancer binding protein, E1AF)
chr5_+_129020069 0.13 ENSMUST00000031383.7
ENSMUST00000111343.1
RAN, member RAS oncogene family
chr10_+_116301374 0.12 ENSMUST00000092167.5
protein tyrosine phosphatase, receptor type, B
chr15_+_98092569 0.10 ENSMUST00000163507.1
phosphofructokinase, muscle
chr15_+_78926720 0.09 ENSMUST00000089377.5
lectin, galactose binding, soluble 1
chr2_-_154569720 0.08 ENSMUST00000000894.5
E2F transcription factor 1
chrX_-_70477170 0.07 ENSMUST00000101506.3
ENSMUST00000114630.2
cDNA sequence BC023829
chr10_+_42860348 0.06 ENSMUST00000063063.7
sex comb on midleg-like 4 (Drosophila)
chr17_+_33909481 0.04 ENSMUST00000173626.1
ENSMUST00000174541.1
Fas death domain-associated protein
chr8_-_109737714 0.03 ENSMUST00000093162.3
ataxin 1-like
chr6_+_29348069 0.01 ENSMUST00000173216.1
ENSMUST00000031779.10
ENSMUST00000090481.7
calumenin
chr4_+_129189760 0.01 ENSMUST00000106054.2
ENSMUST00000001365.2
tyrosyl-tRNA synthetase
chr2_-_155945282 0.01 ENSMUST00000040162.2
growth differentiation factor 5
chr5_+_135187251 0.01 ENSMUST00000002825.5
bromodomain adjacent to zinc finger domain, 1B
chr2_-_157204483 0.01 ENSMUST00000029170.7
retinoblastoma-like 1 (p107)
chr17_+_33909409 0.01 ENSMUST00000173028.1
ENSMUST00000079421.7
Fas death domain-associated protein
chr12_+_84642896 0.01 ENSMUST00000095551.4
vertebrae development associated

Network of associatons between targets according to the STRING database.

First level regulatory network of E2f8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.2 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
1.0 2.9 GO:0071163 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) DNA replication preinitiation complex assembly(GO:0071163) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.5 8.1 GO:0010216 maintenance of DNA methylation(GO:0010216)
0.5 1.6 GO:1902174 positive regulation of keratinocyte apoptotic process(GO:1902174) regulation of sodium-dependent phosphate transport(GO:2000118)
0.5 1.6 GO:0045004 DNA replication proofreading(GO:0045004)
0.5 4.5 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.4 1.8 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.2 6.2 GO:0006270 DNA replication initiation(GO:0006270)
0.2 1.2 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.2 1.6 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.2 1.1 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.2 2.7 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.2 3.4 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.2 0.5 GO:0032474 otolith morphogenesis(GO:0032474)
0.2 1.6 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
0.2 0.9 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.2 0.8 GO:0002121 inter-male aggressive behavior(GO:0002121)
0.1 1.4 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.1 0.3 GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
0.1 0.3 GO:0060382 release from viral latency(GO:0019046) regulation of DNA strand elongation(GO:0060382)
0.1 1.3 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.1 2.6 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.1 1.6 GO:0045475 locomotor rhythm(GO:0045475)
0.1 0.4 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.1 1.3 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.0 0.4 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.1 GO:0045062 extrathymic T cell selection(GO:0045062)
0.0 1.4 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 1.2 GO:0033045 regulation of sister chromatid segregation(GO:0033045)
0.0 0.3 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 1.2 GO:0090307 mitotic spindle assembly(GO:0090307)
0.0 0.1 GO:0033600 negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
0.0 2.3 GO:0007093 mitotic cell cycle checkpoint(GO:0007093)
0.0 0.1 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.0 0.1 GO:0061622 glycolytic process through glucose-1-phosphate(GO:0061622)
0.0 0.1 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.0 0.1 GO:0002317 plasma cell differentiation(GO:0002317)
0.0 0.2 GO:0035562 negative regulation of chromatin binding(GO:0035562)
0.0 0.2 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.1 GO:1990423 RZZ complex(GO:1990423)
1.0 2.9 GO:0005656 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.9 2.6 GO:0033186 CAF-1 complex(GO:0033186)
0.7 3.4 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.5 2.7 GO:0044611 nuclear pore inner ring(GO:0044611)
0.5 7.9 GO:0042555 MCM complex(GO:0042555)
0.5 1.6 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.4 1.8 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.2 1.2 GO:0031523 Myb complex(GO:0031523)
0.2 1.4 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.2 0.9 GO:0005663 DNA replication factor C complex(GO:0005663)
0.1 0.4 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.1 7.2 GO:0005657 replication fork(GO:0005657)
0.1 3.6 GO:0005721 pericentric heterochromatin(GO:0005721)
0.1 2.6 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 1.3 GO:0001673 male germ cell nucleus(GO:0001673)
0.1 0.3 GO:0035189 Rb-E2F complex(GO:0035189)
0.1 1.5 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 1.1 GO:0051233 spindle midzone(GO:0051233)
0.0 0.1 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 2.2 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 0.8 GO:0032590 dendrite membrane(GO:0032590)
0.0 0.2 GO:1904115 axon cytoplasm(GO:1904115)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.5 GO:0031493 nucleosomal histone binding(GO:0031493)
0.7 3.4 GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.6 7.8 GO:0003688 DNA replication origin binding(GO:0003688)
0.5 1.4 GO:0071207 histone pre-mRNA stem-loop binding(GO:0071207)
0.5 1.4 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.4 1.4 GO:0047288 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836) monosialoganglioside sialyltransferase activity(GO:0047288)
0.3 1.6 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.3 2.6 GO:0070087 chromo shadow domain binding(GO:0070087)
0.2 1.7 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 1.2 GO:0045545 syndecan binding(GO:0045545)
0.1 1.8 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.1 2.7 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 1.6 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.1 1.3 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.1 0.4 GO:0034603 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.1 0.9 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 0.8 GO:0019992 diacylglycerol binding(GO:0019992)
0.1 3.0 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 1.6 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 0.4 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.1 1.8 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 1.8 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.0 0.1 GO:0048030 disaccharide binding(GO:0048030)
0.0 0.1 GO:0070883 pre-miRNA binding(GO:0070883)
0.0 3.6 GO:0004386 helicase activity(GO:0004386)
0.0 0.1 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.0 1.4 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.9 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.8 GO:0032452 histone demethylase activity(GO:0032452)
0.0 4.2 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 1.2 GO:0048306 calcium-dependent protein binding(GO:0048306)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 7.0 PID ATR PATHWAY ATR signaling pathway
0.1 3.6 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 4.6 PID E2F PATHWAY E2F transcription factor network
0.0 1.6 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.4 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.9 PID FAS PATHWAY FAS (CD95) signaling pathway
0.0 0.1 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.5 PID ERBB4 PATHWAY ErbB4 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 10.8 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.3 5.4 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.3 4.6 REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND Genes involved in Processive synthesis on the lagging strand
0.2 1.8 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 1.2 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 1.4 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.1 2.8 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 0.8 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.4 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 1.6 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 3.5 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 2.1 REACTOME MRNA SPLICING Genes involved in mRNA Splicing