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12D miR HR13_24

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Results for Relb

Z-value: 0.29

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Transcription factors associated with Relb

Gene Symbol Gene ID Gene Info
ENSMUSG00000002983.10 avian reticuloendotheliosis viral (v-rel) oncogene related B

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Relbmm10_v2_chr7_-_19629355_19629451-0.215.3e-01Click!

Activity profile of Relb motif

Sorted Z-values of Relb motif

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_90891234 0.37 ENSMUST00000031327.8
chemokine (C-X-C motif) ligand 1
chr1_-_171196229 0.31 ENSMUST00000111332.1
Purkinje cell protein 4-like 1
chr2_-_27027909 0.27 ENSMUST00000102890.4
ENSMUST00000153388.1
ENSMUST00000045702.5
solute carrier family 2 (facilitated glucose transporter), member 6
chr2_-_5714490 0.24 ENSMUST00000044009.7
calcium/calmodulin-dependent protein kinase ID
chr2_+_10153563 0.24 ENSMUST00000026886.7
inter-alpha (globulin) inhibitor H5
chr5_+_90759299 0.20 ENSMUST00000031318.4
chemokine (C-X-C motif) ligand 5
chr11_+_90030295 0.18 ENSMUST00000092788.3
transmembrane protein 100
chr12_+_111166485 0.15 ENSMUST00000139162.1
TNF receptor-associated factor 3
chr2_-_125506385 0.14 ENSMUST00000028633.6
fibrillin 1
chr4_-_117125618 0.13 ENSMUST00000183310.1
BTB (POZ) domain containing 19
chr2_-_160313616 0.13 ENSMUST00000109475.2
predicted gene 826
chr17_+_42315947 0.12 ENSMUST00000048691.4
patched domain containing 4
chr9_-_97018823 0.11 ENSMUST00000055433.4
splA/ryanodine receptor domain and SOCS box containing 4
chr4_+_99656299 0.11 ENSMUST00000087285.3
forkhead box D3
chr17_+_35424870 0.10 ENSMUST00000113879.3
histocompatibility 2, Q region locus 6
chr4_+_130915949 0.10 ENSMUST00000030316.6
lysosomal-associated protein transmembrane 5
chr17_+_74717743 0.10 ENSMUST00000024882.6
tetratricopeptide repeat domain 27
chr1_+_193301953 0.10 ENSMUST00000016315.9
laminin, beta 3
chr12_+_102948843 0.09 ENSMUST00000101099.5
unc-79 homolog (C. elegans)
chr10_+_79664553 0.09 ENSMUST00000020554.6
mucosal vascular addressin cell adhesion molecule 1
chr2_-_73485733 0.08 ENSMUST00000102680.1
WAS/WASL interacting protein family, member 1
chr6_+_122513583 0.08 ENSMUST00000032210.7
ENSMUST00000148517.1
microfibrillar associated protein 5
chr7_+_16309577 0.08 ENSMUST00000002152.6
BCL2 binding component 3
chr17_+_35424842 0.08 ENSMUST00000174699.1
histocompatibility 2, Q region locus 6
chr4_-_91399984 0.08 ENSMUST00000102799.3
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr7_-_70360593 0.08 ENSMUST00000032768.7
nuclear receptor subfamily 2, group F, member 2
chr18_+_36559972 0.08 ENSMUST00000134146.1
ankyrin repeat and KH domain containing 1
chr7_-_45920830 0.08 ENSMUST00000164119.1
epithelial membrane protein 3
chr5_-_134678190 0.07 ENSMUST00000111233.1
LIM-domain containing, protein kinase
chr16_+_32914094 0.06 ENSMUST00000023491.6
ENSMUST00000170899.1
ENSMUST00000171118.1
ENSMUST00000170201.1
ENSMUST00000165616.1
ENSMUST00000135193.2
leucine-rich repeats and calponin homology (CH) domain containing 3
chr7_+_43463145 0.06 ENSMUST00000107977.1
ZV-set and immunoglobulin domain containing 10 like
chr1_-_170589791 0.06 ENSMUST00000161966.1
ENSMUST00000160456.1
nitric oxide synthase 1 (neuronal) adaptor protein
chrX_+_157699113 0.06 ENSMUST00000112521.1
small muscle protein, X-linked
chr1_+_15287259 0.05 ENSMUST00000175681.1
potassium voltage gated channel, Shab-related subfamily, member 2
chr9_+_110132015 0.05 ENSMUST00000088716.5
ENSMUST00000111969.1
ENSMUST00000035057.7
ENSMUST00000111966.1
ENSMUST00000111968.1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr12_-_54862783 0.05 ENSMUST00000078124.7
cofilin 2, muscle
chr4_+_100776664 0.04 ENSMUST00000030257.8
ENSMUST00000097955.2
cache domain containing 1
chrX_+_36112110 0.04 ENSMUST00000033418.7
interleukin 13 receptor, alpha 1
chr16_+_97997313 0.04 ENSMUST00000122450.1
RIKEN cDNA B230307C23 gene
chr12_+_85686648 0.04 ENSMUST00000040536.5
basic leucine zipper transcription factor, ATF-like
chr8_+_72319033 0.04 ENSMUST00000067912.7
Kruppel-like factor 2 (lung)
chr2_+_18672384 0.04 ENSMUST00000171845.1
ENSMUST00000061158.4
COMM domain containing 3
chrX_+_141475385 0.04 ENSMUST00000112931.1
ENSMUST00000112930.1
collagen, type IV, alpha 5
chr8_+_46739745 0.04 ENSMUST00000034041.7
interferon regulatory factor 2
chr13_+_44730726 0.04 ENSMUST00000173704.1
ENSMUST00000044608.7
ENSMUST00000173367.1
jumonji, AT rich interactive domain 2
chr12_+_111166349 0.03 ENSMUST00000117269.1
TNF receptor-associated factor 3
chr14_+_120478443 0.03 ENSMUST00000062117.6
RAS related protein 2a
chr15_-_98677451 0.03 ENSMUST00000120997.1
ENSMUST00000109149.2
ENSMUST00000003451.4
Rho family GTPase 1
chr3_+_51415986 0.03 ENSMUST00000029303.7
N(alpha)-acetyltransferase 15, NatA auxiliary subunit
chr4_+_129820198 0.03 ENSMUST00000030578.7
protein tyrosine phosphatase 4a2
chr12_+_111166413 0.03 ENSMUST00000021706.4
TNF receptor-associated factor 3
chr4_+_43631935 0.03 ENSMUST00000030191.8
natriuretic peptide receptor 2
chr6_-_124741374 0.03 ENSMUST00000004389.5
gene rich cluster, C10 gene
chr3_-_9610074 0.02 ENSMUST00000041124.7
zinc finger protein 704
chr4_-_152131865 0.02 ENSMUST00000105653.1
espin
chr5_+_150259922 0.02 ENSMUST00000087204.5
furry homolog (Drosophila)
chr10_+_102512216 0.02 ENSMUST00000055355.4
Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
chr5_+_33658123 0.01 ENSMUST00000074849.6
ENSMUST00000079534.4
transforming, acidic coiled-coil containing protein 3
chr16_-_30267524 0.01 ENSMUST00000064856.7
carboxypeptidase N, polypeptide 2
chr12_-_55492587 0.01 ENSMUST00000021413.7
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
chr12_-_84194007 0.01 ENSMUST00000110294.1
ELM2 and Myb/SANT-like domain containing 1
chr18_+_37484955 0.01 ENSMUST00000053856.4
protocadherin beta 17
chr7_-_102250086 0.01 ENSMUST00000106923.1
ENSMUST00000098230.4
ras homolog gene family, member G
chr5_-_110448486 0.00 ENSMUST00000069483.5
fibrosin-like 1
chr1_+_135133272 0.00 ENSMUST00000167080.1
protein tyrosine phosphatase, non-receptor type 7
chr3_-_107760221 0.00 ENSMUST00000153114.1
ENSMUST00000118593.1
ENSMUST00000120243.1
colony stimulating factor 1 (macrophage)

Network of associatons between targets according to the STRING database.

First level regulatory network of Relb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0070949 regulation of neutrophil mediated cytotoxicity(GO:0070948) regulation of neutrophil mediated killing of symbiont cell(GO:0070949)
0.0 0.1 GO:2001205 negative regulation of osteoclast development(GO:2001205)
0.0 0.2 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.0 0.2 GO:0060842 arterial endothelial cell differentiation(GO:0060842)
0.0 0.1 GO:1900739 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.0 0.1 GO:2000170 positive regulation of peptidyl-cysteine S-nitrosylation(GO:2000170)
0.0 0.2 GO:0008063 Toll signaling pathway(GO:0008063)
0.0 0.3 GO:0035428 hexose transmembrane transport(GO:0035428)
0.0 0.1 GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.0 0.0 GO:0030043 actin filament fragmentation(GO:0030043)
0.0 0.0 GO:0035962 response to interleukin-13(GO:0035962) cellular response to interleukin-13(GO:0035963)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0005610 laminin-5 complex(GO:0005610)
0.0 0.2 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.1 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.0 0.2 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 0.2 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.1 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.0 0.1 GO:0098634 protein binding involved in cell-matrix adhesion(GO:0098634)
0.0 0.2 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.0 0.2 GO:0031996 thioesterase binding(GO:0031996)
0.0 0.3 GO:0005402 sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.6 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.2 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon