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12D miR HR13_24

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Results for Runx3

Z-value: 0.60

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Transcription factors associated with Runx3

Gene Symbol Gene ID Gene Info
ENSMUSG00000070691.4 runt related transcription factor 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Runx3mm10_v2_chr4_+_135120640_1351206600.244.7e-01Click!

Activity profile of Runx3 motif

Sorted Z-values of Runx3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr13_-_23551648 0.93 ENSMUST00000102971.1
histone cluster 1, H4f
chr7_-_44974781 0.80 ENSMUST00000063761.7
carnitine palmitoyltransferase 1c
chr5_+_21424934 0.62 ENSMUST00000056045.4
family with sequence similarity 185, member A
chr10_-_81001338 0.54 ENSMUST00000099462.1
ENSMUST00000118233.1
guanine nucleotide binding protein (G protein), gamma 7
chr13_-_22041352 0.54 ENSMUST00000102977.2
histone cluster 1, H4i
chr6_-_100671126 0.53 ENSMUST00000089245.6
ENSMUST00000113312.2
ENSMUST00000170667.1
SHQ1 homolog (S. cerevisiae)
chr18_-_47368446 0.52 ENSMUST00000076043.6
ENSMUST00000135790.1
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr13_+_51645232 0.47 ENSMUST00000075853.5
CDC28 protein kinase regulatory subunit 2
chr17_+_28328471 0.44 ENSMUST00000042334.8
ribosomal protein L10A
chr13_-_23698454 0.43 ENSMUST00000102967.1
histone cluster 1, H4c
chr7_-_141437587 0.43 ENSMUST00000172654.1
ENSMUST00000106006.1
solute carrier family 25 (mitochondrial carrier, glutamate), member 22
chr4_-_120570252 0.42 ENSMUST00000030381.7
cytidine 5'-triphosphate synthase
chr13_-_21832194 0.41 ENSMUST00000102979.1
histone cluster 1, H4n
chr17_+_27556668 0.40 ENSMUST00000117254.1
ENSMUST00000118570.1
high mobility group AT-hook 1
chr17_+_27556641 0.39 ENSMUST00000119486.1
ENSMUST00000118599.1
high mobility group AT-hook 1
chr17_+_27556613 0.38 ENSMUST00000117600.1
ENSMUST00000114888.3
high mobility group AT-hook 1
chr8_+_4243264 0.38 ENSMUST00000110996.1
mitogen-activated protein kinase kinase 7
chr2_+_72476159 0.37 ENSMUST00000102691.4
cell division cycle associated 7
chr5_+_121397936 0.32 ENSMUST00000042163.8
N(alpha)-acetyltransferase 25, NatB auxiliary subunit
chr7_-_142095266 0.31 ENSMUST00000039926.3
dual specificity phosphatase 8
chr11_-_5878207 0.30 ENSMUST00000102922.3
polymerase (DNA directed), delta 2, regulatory subunit
chr9_+_106429537 0.30 ENSMUST00000059802.6
ribosomal protein L29
chr10_-_62602261 0.28 ENSMUST00000045866.7
DEAD (Asp-Glu-Ala-Asp) box polypeptide 21
chr9_+_106429399 0.27 ENSMUST00000150576.1
ribosomal protein L29
chrX_-_147554050 0.26 ENSMUST00000112819.2
ENSMUST00000136789.1
leucine-rich repeats and calponin homology (CH) domain containing 2
chr17_-_6961156 0.24 ENSMUST00000063683.6
T cell activation GTPase activating protein 1
chr9_+_70012540 0.24 ENSMUST00000118198.1
ENSMUST00000119905.1
ENSMUST00000119413.1
ENSMUST00000140305.1
ENSMUST00000122087.1
general transcription factor II A, 2
chr13_-_35906324 0.23 ENSMUST00000174230.1
ENSMUST00000171686.2
ribonuclease P 40 subunit
chr5_+_45493374 0.22 ENSMUST00000046122.6
leucine aminopeptidase 3
chr5_-_21424664 0.21 ENSMUST00000115245.1
ENSMUST00000030552.5
coiled-coil domain containing 146
chr9_-_78481724 0.21 ENSMUST00000042235.8
eukaryotic translation elongation factor 1 alpha 1
chr17_+_8165501 0.20 ENSMUST00000097419.3
ENSMUST00000024636.8
Fgfr1 oncogene partner
chr11_+_75532127 0.19 ENSMUST00000127226.1
solute carrier family 43, member 2
chr13_+_21735055 0.19 ENSMUST00000087714.4
histone cluster 1, H4j
chr9_-_20898592 0.16 ENSMUST00000004206.8
eukaryotic translation initiation factor 3, subunit G
chr7_+_78783119 0.16 ENSMUST00000032840.4
mitochondrial ribosomal protein S11
chr18_+_37355271 0.15 ENSMUST00000051163.1
protocadherin beta 8
chr9_-_108094459 0.15 ENSMUST00000081309.7
acylpeptide hydrolase
chr2_+_72476225 0.15 ENSMUST00000157019.1
cell division cycle associated 7
chr11_+_75532099 0.15 ENSMUST00000169547.2
solute carrier family 43, member 2
chr4_-_133498538 0.14 ENSMUST00000125541.1
TMF1-regulated nuclear protein 1
chr3_+_122245557 0.14 ENSMUST00000029769.7
glutamate-cysteine ligase, modifier subunit
chr11_-_84916338 0.13 ENSMUST00000103195.4
zinc finger, HIT type 3
chr7_+_35802593 0.13 ENSMUST00000052454.2
RIKEN cDNA E130304I02 gene
chr1_+_74278550 0.12 ENSMUST00000077985.3
G protein-coupled bile acid receptor 1
chr11_-_70410010 0.12 ENSMUST00000019065.3
ENSMUST00000135148.1
proline, glutamic acid and leucine rich protein 1
chr10_+_128083273 0.12 ENSMUST00000026459.5
ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit
chr8_-_27128615 0.11 ENSMUST00000033877.4
BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like
chr13_-_115101909 0.11 ENSMUST00000061673.7
integrin alpha 1
chr11_-_70220969 0.10 ENSMUST00000060010.2
solute carrier family 16 (monocarboxylic acid transporters), member 13
chr7_-_35802968 0.09 ENSMUST00000061586.4
zinc finger protein 507
chr3_+_121953213 0.09 ENSMUST00000037958.7
ENSMUST00000128366.1
Rho GTPase activating protein 29
chr17_-_23599487 0.09 ENSMUST00000057029.4
zinc finger protein 13
chr5_+_25222862 0.08 ENSMUST00000045737.7
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11
chr18_-_34651703 0.07 ENSMUST00000025228.5
ENSMUST00000133181.1
CDC23 cell division cycle 23
chr8_-_115706994 0.06 ENSMUST00000069009.6
avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog
chr19_+_5038826 0.06 ENSMUST00000053705.6
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
chr7_-_16816731 0.06 ENSMUST00000061390.7
fukutin related protein
chr3_+_122245625 0.06 ENSMUST00000178826.1
glutamate-cysteine ligase, modifier subunit
chr9_+_122117338 0.05 ENSMUST00000120173.1
ENSMUST00000134949.1
ENSMUST00000119215.1
SNF related kinase
chr11_-_32267547 0.05 ENSMUST00000109389.2
ENSMUST00000129010.1
ENSMUST00000020530.5
nitrogen permease regulator-like 3
chr4_+_19575139 0.05 ENSMUST00000108253.1
ENSMUST00000029888.3
regulator of microtubule dynamics 1
chr11_-_49113757 0.05 ENSMUST00000060398.1
olfactory receptor 1396
chr7_+_28808795 0.04 ENSMUST00000172529.1
heterogeneous nuclear ribonucleoprotein L
chrX_-_73869804 0.04 ENSMUST00000066576.5
ENSMUST00000114430.1
L1 cell adhesion molecule
chr8_-_11008458 0.04 ENSMUST00000040514.6
insulin receptor substrate 2
chr7_+_127091426 0.03 ENSMUST00000056288.5
expressed sequence AI467606
chr18_-_61786636 0.03 ENSMUST00000120472.1
actin filament associated protein 1-like 1
chr4_-_70410422 0.03 ENSMUST00000144099.1
CDK5 regulatory subunit associated protein 2
chr1_+_40465552 0.02 ENSMUST00000167723.1
interleukin 18 receptor 1
chr8_-_54724474 0.02 ENSMUST00000175915.1
WD repeat domain 17
chr2_-_50296680 0.02 ENSMUST00000144143.1
ENSMUST00000102769.4
ENSMUST00000133768.1
methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria
chr11_-_70220794 0.02 ENSMUST00000159867.1
solute carrier family 16 (monocarboxylic acid transporters), member 13
chr6_-_135254170 0.01 ENSMUST00000111909.1
germ cell-specific gene 1
chr9_+_121719403 0.01 ENSMUST00000182225.1
natural killer tumor recognition sequence
chr13_-_76018524 0.01 ENSMUST00000050997.1
ENSMUST00000179078.1
ENSMUST00000167271.1
Rieske (Fe-S) domain containing
chr1_+_40465976 0.01 ENSMUST00000108044.2
ENSMUST00000087983.2
interleukin 18 receptor 1
chr7_-_78783026 0.01 ENSMUST00000032841.5
mitochondrial ribosomal protein L46
chr13_-_25020289 0.00 ENSMUST00000021772.2
MRS2 magnesium homeostasis factor homolog (S. cerevisiae)
chr9_+_110532501 0.00 ENSMUST00000153838.2
SET domain containing 2

Network of associatons between targets according to the STRING database.

First level regulatory network of Runx3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0090071 negative regulation of ribosome biogenesis(GO:0090071)
0.1 2.5 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.1 0.5 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1 0.8 GO:0009437 carnitine metabolic process(GO:0009437)
0.0 0.3 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0 0.4 GO:0006241 CTP biosynthetic process(GO:0006241) CTP metabolic process(GO:0046036)
0.0 0.2 GO:0075525 viral translational termination-reinitiation(GO:0075525)
0.0 0.4 GO:2000671 regulation of motor neuron apoptotic process(GO:2000671)
0.0 0.3 GO:0006271 DNA strand elongation involved in DNA replication(GO:0006271)
0.0 1.2 GO:0006284 base-excision repair(GO:0006284)
0.0 0.1 GO:0010726 positive regulation of hydrogen peroxide metabolic process(GO:0010726)
0.0 0.2 GO:0051409 response to nitrosative stress(GO:0051409)
0.0 0.5 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.0 0.2 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.0 0.1 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.0 0.4 GO:0015813 L-glutamate transport(GO:0015813)
0.0 0.3 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.4 GO:0000470 maturation of LSU-rRNA(GO:0000470)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.1 0.3 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.1 0.2 GO:0017109 glutamate-cysteine ligase complex(GO:0017109)
0.1 2.0 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.2 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.0 0.6 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.2 GO:0005655 nucleolar ribonuclease P complex(GO:0005655)
0.0 0.3 GO:0031414 N-terminal protein acetyltransferase complex(GO:0031414)
0.0 0.8 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.1 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0 0.4 GO:0000786 nucleosome(GO:0000786)
0.0 0.1 GO:1990130 Iml1 complex(GO:1990130)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.1 1.2 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.1 0.5 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.1 0.4 GO:0003883 CTP synthase activity(GO:0003883)
0.1 0.4 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.1 0.2 GO:0004357 glutamate-cysteine ligase activity(GO:0004357)
0.0 0.2 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.3 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 0.4 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 0.5 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.1 GO:0038181 bile acid receptor activity(GO:0038181)
0.0 0.1 GO:0043532 angiostatin binding(GO:0043532)
0.0 0.1 GO:0001032 RNA polymerase III type 3 promoter DNA binding(GO:0001032)
0.0 0.3 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.1 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.0 0.2 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 0.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.2 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.3 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 1.7 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.8 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1 2.0 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.3 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.6 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.4 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.4 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 0.5 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 1.2 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.2 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex