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12D miR HR13_24

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Results for Zfp423

Z-value: 1.02

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Transcription factors associated with Zfp423

Gene Symbol Gene ID Gene Info
ENSMUSG00000045333.9 zinc finger protein 423

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Zfp423mm10_v2_chr8_-_87804411_878044630.793.7e-03Click!

Activity profile of Zfp423 motif

Sorted Z-values of Zfp423 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_109459843 3.74 ENSMUST00000173812.1
delta-like 1 homolog (Drosophila)
chr19_-_10101501 2.29 ENSMUST00000025567.7
fatty acid desaturase 2
chr7_+_29307924 2.27 ENSMUST00000108230.1
ENSMUST00000065181.5
D4, zinc and double PHD fingers family 1
chr19_+_7268296 2.14 ENSMUST00000066646.4
REST corepressor 2
chr17_+_55986494 1.90 ENSMUST00000011733.8
fibronectin type 3 and SPRY domain-containing protein
chr19_-_10869757 1.57 ENSMUST00000120524.1
ENSMUST00000025645.7
transmembrane protein 132A
chr4_-_106464167 1.41 ENSMUST00000049507.5
proprotein convertase subtilisin/kexin type 9
chrX_-_75130844 1.37 ENSMUST00000114092.1
ENSMUST00000132501.1
ENSMUST00000153318.1
ENSMUST00000155742.1
membrane protein, palmitoylated
chr4_-_108032069 1.37 ENSMUST00000106709.2
podocan
chr15_-_78718113 1.17 ENSMUST00000088592.4
leucine rich repeat and fibronectin type III, extracellular 2
chr2_+_163547148 1.13 ENSMUST00000109411.1
ENSMUST00000018094.6
hepatic nuclear factor 4, alpha
chr12_+_102948843 1.05 ENSMUST00000101099.5
unc-79 homolog (C. elegans)
chr4_+_129513581 0.99 ENSMUST00000062356.6
MARCKS-like 1
chr9_-_37552904 0.92 ENSMUST00000065668.5
neurogranin
chr4_-_108031938 0.84 ENSMUST00000106708.1
podocan
chr5_+_31297551 0.83 ENSMUST00000072228.5
glucokinase regulatory protein
chr17_-_32166879 0.83 ENSMUST00000087723.3
notch 3
chr4_-_117125618 0.82 ENSMUST00000183310.1
BTB (POZ) domain containing 19
chr18_+_4920509 0.80 ENSMUST00000126977.1
supervillin
chr8_-_120177420 0.73 ENSMUST00000135567.2
family with sequence similarity 92, member B
chr7_-_141443314 0.72 ENSMUST00000106005.2
leucine-rich and death domain containing
chrX_-_75130914 0.62 ENSMUST00000114091.1
membrane protein, palmitoylated
chr15_-_66286224 0.60 ENSMUST00000070256.7
potassium voltage-gated channel, subfamily Q, member 3
chrX_-_75130996 0.58 ENSMUST00000033775.2
membrane protein, palmitoylated
chr2_+_133552159 0.58 ENSMUST00000028836.6
bone morphogenetic protein 2
chr11_+_82101836 0.55 ENSMUST00000000194.3
chemokine (C-C motif) ligand 12
chr13_-_47106176 0.52 ENSMUST00000021807.6
ENSMUST00000135278.1
DEK oncogene (DNA binding)
chr6_-_124415037 0.51 ENSMUST00000035861.5
ENSMUST00000112532.1
ENSMUST00000080557.5
peroxisomal biogenesis factor 5
chr10_+_3973086 0.47 ENSMUST00000117291.1
ENSMUST00000120585.1
ENSMUST00000043735.7
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr2_-_29055051 0.46 ENSMUST00000113843.1
ENSMUST00000157048.2
RIKEN cDNA 1700101E01 gene
chr7_-_120670256 0.44 ENSMUST00000033178.2
PDZ domain containing 9
chr14_+_119138415 0.43 ENSMUST00000065904.3
heparan sulfate 6-O-sulfotransferase 3
chr5_-_135934590 0.40 ENSMUST00000055808.5
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
chr2_+_164785994 0.40 ENSMUST00000152471.1
sorting nexin family member 21
chr15_+_89253035 0.40 ENSMUST00000088788.3
protein phosphatase 6, regulatory subunit 2
chr7_-_19458494 0.39 ENSMUST00000085715.5
MAP/microtubule affinity-regulating kinase 4
chr8_-_120177440 0.38 ENSMUST00000048786.6
family with sequence similarity 92, member B
chr14_+_70553687 0.38 ENSMUST00000161069.1
hairless
chr10_+_81136223 0.35 ENSMUST00000048128.8
zinc finger and BTB domain containing 7a
chr19_+_10041548 0.35 ENSMUST00000115995.2
fatty acid desaturase 3
chr4_-_148626756 0.34 ENSMUST00000105699.1
TAR DNA binding protein
chr7_-_70360593 0.33 ENSMUST00000032768.7
nuclear receptor subfamily 2, group F, member 2
chr11_-_76846968 0.33 ENSMUST00000021201.5
carboxypeptidase D
chr6_+_113471481 0.32 ENSMUST00000113062.1
interleukin 17 receptor C
chr7_+_45705518 0.30 ENSMUST00000107740.1
ENSMUST00000107741.1
D site albumin promoter binding protein
chr10_+_13966268 0.29 ENSMUST00000015645.4
human immunodeficiency virus type I enhancer binding protein 2
chr1_-_54926311 0.29 ENSMUST00000179030.1
ENSMUST00000044359.9
ankyrin repeat domain 44
chr17_-_10840285 0.26 ENSMUST00000041463.6
PARK2 co-regulated
chr6_+_37900477 0.25 ENSMUST00000120238.1
tripartite motif-containing 24
chr15_+_101293196 0.24 ENSMUST00000071328.6
RIKEN cDNA 6030408B16 gene
chr6_-_128200598 0.23 ENSMUST00000071101.6
predicted gene 10010
chr8_-_83699095 0.22 ENSMUST00000005616.8
protein kinase N1
chr18_+_34759551 0.22 ENSMUST00000097622.3
family with sequence similarity 53, member C
chr8_+_58912257 0.21 ENSMUST00000160055.1
cDNA sequence BC030500
chr10_+_81136534 0.21 ENSMUST00000119606.1
ENSMUST00000146895.1
ENSMUST00000121840.1
zinc finger and BTB domain containing 7a
chr7_-_45694369 0.21 ENSMUST00000040636.6
secretory blood group 1
chr4_+_129820198 0.20 ENSMUST00000030578.7
protein tyrosine phosphatase 4a2
chr1_+_167598450 0.19 ENSMUST00000111386.1
ENSMUST00000111384.1
retinoid X receptor gamma
chr11_+_102836296 0.18 ENSMUST00000021302.8
ENSMUST00000107072.1
HIG1 domain family, member 1B
chr4_+_154237525 0.18 ENSMUST00000152159.1
multiple EGF-like-domains 6
chr10_+_60349318 0.17 ENSMUST00000105459.1
RIKEN cDNA 4632428N05 gene
chr10_-_127620960 0.17 ENSMUST00000121829.1
low density lipoprotein receptor-related protein 1
chr8_-_41016749 0.17 ENSMUST00000117735.1
mitochondrial tumor suppressor 1
chr2_+_164785823 0.17 ENSMUST00000174070.1
ENSMUST00000172577.1
ENSMUST00000056181.6
sorting nexin family member 21
chr7_-_133122615 0.17 ENSMUST00000167218.1
C-terminal binding protein 2
chr6_+_113471427 0.15 ENSMUST00000058300.7
interleukin 17 receptor C
chr17_-_36867187 0.14 ENSMUST00000025329.6
ENSMUST00000174195.1
tripartite motif-containing 15
chr6_-_97205549 0.14 ENSMUST00000164744.1
ENSMUST00000089287.5
ubiquitin-like modifier activating enzyme 3
chr1_+_167598384 0.14 ENSMUST00000015987.3
retinoid X receptor gamma
chr10_-_127620922 0.13 ENSMUST00000118455.1
low density lipoprotein receptor-related protein 1
chr12_-_69183986 0.13 ENSMUST00000110620.1
ENSMUST00000110619.1
ribosomal protein L36A-like
chr16_+_58408443 0.12 ENSMUST00000046663.7
discoidin, CUB and LCCL domain containing 2
chr14_-_70520254 0.12 ENSMUST00000022693.7
bone morphogenetic protein 1
chr18_-_80151467 0.11 ENSMUST00000066743.9
ADNP homeobox 2
chr7_-_34196608 0.11 ENSMUST00000148381.1
ENSMUST00000002710.3
programmed cell death 2-like
chr2_-_30359190 0.10 ENSMUST00000100215.4
ENSMUST00000113620.3
SH3-domain GRB2-like endophilin B2
chrX_+_58030999 0.09 ENSMUST00000088631.4
ENSMUST00000088629.3
zinc finger protein of the cerebellum 3
chr5_+_115429944 0.09 ENSMUST00000067168.5
musashi RNA-binding protein 1
chr13_+_42052015 0.09 ENSMUST00000060148.5
human immunodeficiency virus type I enhancer binding protein 1
chr19_+_6401675 0.08 ENSMUST00000113471.1
ENSMUST00000113469.2
RAS, guanyl releasing protein 2
chr12_-_69184056 0.08 ENSMUST00000054544.6
ribosomal protein L36A-like
chr2_+_13573927 0.07 ENSMUST00000141365.1
ENSMUST00000028062.2
vimentin
chr7_+_127485221 0.06 ENSMUST00000048896.6
fibrosin
chr11_+_60469339 0.03 ENSMUST00000071880.2
ENSMUST00000081823.5
ENSMUST00000094135.2
myosin XV
chr12_-_14152038 0.03 ENSMUST00000020926.6
family with sequence similarity 84, member A
chrX_+_58030622 0.01 ENSMUST00000088627.4
zinc finger protein of the cerebellum 3
chr2_-_30359278 0.01 ENSMUST00000163668.2
ENSMUST00000028214.8
ENSMUST00000113621.3
SH3-domain GRB2-like endophilin B2
chr7_-_16286744 0.00 ENSMUST00000150528.2
ENSMUST00000118976.2
ENSMUST00000146609.2
coiled-coil domain containing 9

Network of associatons between targets according to the STRING database.

First level regulatory network of Zfp423

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:1902569 regulation of activation of JAK2 kinase activity(GO:0010534) activation of JAK2 kinase activity(GO:0042977) negative regulation of activation of JAK2 kinase activity(GO:1902569)
0.4 1.4 GO:0032805 positive regulation of low-density lipoprotein particle receptor catabolic process(GO:0032805)
0.2 0.8 GO:0009750 response to fructose(GO:0009750)
0.2 0.5 GO:0016561 protein import into peroxisome matrix, translocation(GO:0016561)
0.2 0.8 GO:0072103 glomerulus vasculature morphogenesis(GO:0072103) glomerular capillary formation(GO:0072104)
0.1 0.6 GO:0003133 BMP signaling pathway involved in heart induction(GO:0003130) endodermal-mesodermal cell signaling(GO:0003133) endodermal-mesodermal cell signaling involved in heart induction(GO:0003134) embryonic heart tube anterior/posterior pattern specification(GO:0035054) corticotropin hormone secreting cell differentiation(GO:0060128)
0.1 0.5 GO:2000402 negative regulation of lymphocyte migration(GO:2000402)
0.1 3.7 GO:0045780 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.1 1.0 GO:0048149 behavioral response to ethanol(GO:0048149)
0.1 0.5 GO:0009256 10-formyltetrahydrofolate metabolic process(GO:0009256) tetrahydrofolate biosynthetic process(GO:0046654)
0.1 0.3 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
0.1 0.5 GO:0044838 cell quiescence(GO:0044838) regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.1 0.4 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1 0.3 GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.1 2.6 GO:0090022 regulation of neutrophil chemotaxis(GO:0090022)
0.0 0.2 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.0 0.3 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.0 0.1 GO:0007113 endomitotic cell cycle(GO:0007113)
0.0 0.3 GO:0071763 nuclear membrane organization(GO:0071763)
0.0 0.1 GO:1901252 regulation of intracellular transport of viral material(GO:1901252)
0.0 2.2 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.6 GO:0060081 membrane hyperpolarization(GO:0060081)
0.0 0.5 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.0 0.6 GO:1900273 positive regulation of long-term synaptic potentiation(GO:1900273)
0.0 0.4 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.0 0.1 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.0 0.2 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 2.6 GO:0006633 fatty acid biosynthetic process(GO:0006633)
0.0 0.1 GO:0036135 Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
0.0 1.2 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.4 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.1 2.3 GO:0071565 nBAF complex(GO:0071565)
0.1 0.9 GO:0044327 dendritic spine head(GO:0044327)
0.1 0.3 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.8 GO:0043034 costamere(GO:0043034)
0.0 2.3 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.5 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.6 GO:0033268 node of Ranvier(GO:0033268)
0.0 2.6 GO:0030863 cortical cytoskeleton(GO:0030863)
0.0 0.4 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.3 GO:0097225 sperm midpiece(GO:0097225)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0034189 very-low-density lipoprotein particle binding(GO:0034189)
0.5 2.3 GO:0004768 stearoyl-CoA 9-desaturase activity(GO:0004768)
0.4 1.1 GO:0070540 stearic acid binding(GO:0070540)
0.1 0.5 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.1 0.5 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.1 0.4 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.1 0.8 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.1 0.3 GO:0016964 alpha-2 macroglobulin receptor activity(GO:0016964)
0.1 0.5 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.1 0.6 GO:0019211 phosphatase activator activity(GO:0019211)
0.1 0.2 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.1 0.2 GO:0031127 galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.1 0.5 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 0.9 GO:0070300 phosphatidic acid binding(GO:0070300)
0.0 0.4 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 0.3 GO:0034056 estrogen response element binding(GO:0034056)
0.0 0.3 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.0 0.3 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 2.2 GO:0005518 collagen binding(GO:0005518)
0.0 1.2 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.3 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.4 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.2 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.0 0.1 GO:1990254 keratin filament binding(GO:1990254)
0.0 0.4 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 0.1 GO:0008641 small protein activating enzyme activity(GO:0008641)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.9 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 2.2 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.2 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.4 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 0.8 REACTOME SIGNALING BY NOTCH3 Genes involved in Signaling by NOTCH3
0.1 2.3 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.1 3.7 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 1.1 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.8 REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.6 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.6 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.4 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis