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12D miR HR13_24
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Results for Atf4
Z-value: 1.35
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Transcription factors associated with Atf4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Atf4 | mm10_v2_chr15_+_80255184_80255263 | 0.58 | 6.1e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_119351222 Show fit | 4.07 |
ENSMUST00000028780.3
|
ChaC, cation transport regulator 1 |
|
| chr10_-_83533383 Show fit | 2.80 |
ENSMUST00000146640.1
|
aldehyde dehydrogenase 1 family, member L2 |
|
| chrX_+_164438039 Show fit | 2.65 |
ENSMUST00000033755.5
|
ankyrin repeat and SOCS box-containing 11 |
|
| chr7_-_45615484 Show fit | 2.27 |
ENSMUST00000033099.4
|
fibroblast growth factor 21 |
|
| chr11_-_58534825 Show fit | 2.13 |
ENSMUST00000170009.1
|
olfactory receptor 330 |
|
| chr7_-_126625676 Show fit | 1.76 |
ENSMUST00000032961.3
|
nuclear protein transcription regulator 1 |
|
| chr7_+_78913401 Show fit | 1.50 |
ENSMUST00000118867.1
|
interferon-stimulated protein |
|
| chrX_+_103422010 Show fit | 1.46 |
ENSMUST00000182089.1
|
predicted gene, 26992 |
|
| chr7_+_78913436 Show fit | 1.33 |
ENSMUST00000121645.1
|
interferon-stimulated protein |
|
| chr7_-_143600049 Show fit | 1.27 |
ENSMUST00000105909.3
ENSMUST00000010899.7 |
cysteinyl-tRNA synthetase |
Network of associatons between targets according to the STRING database.
First level regulatory network of Atf4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 4.8 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 0.3 | 4.1 | GO:0006751 | glutathione catabolic process(GO:0006751) |
| 0.9 | 2.8 | GO:0009397 | 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560) |
| 0.6 | 2.3 | GO:0015825 | L-serine transport(GO:0015825) |
| 0.5 | 2.3 | GO:1904721 | regulation of mRNA cleavage(GO:0031437) negative regulation of mRNA cleavage(GO:0031438) regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904720) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721) |
| 0.3 | 2.3 | GO:0090080 | positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080) |
| 0.4 | 2.1 | GO:0051012 | microtubule sliding(GO:0051012) |
| 0.0 | 2.1 | GO:0007608 | sensory perception of smell(GO:0007608) |
| 0.1 | 1.8 | GO:2000194 | regulation of female gonad development(GO:2000194) |
| 0.0 | 1.5 | GO:0006506 | GPI anchor biosynthetic process(GO:0006506) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.8 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 4.1 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 2.3 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 2.1 | GO:0072686 | mitotic spindle(GO:0072686) |
| 0.0 | 1.6 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.0 | 1.5 | GO:0031227 | intrinsic component of endoplasmic reticulum membrane(GO:0031227) |
| 0.3 | 1.0 | GO:0036488 | CHOP-C/EBP complex(GO:0036488) |
| 0.1 | 1.0 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.1 | 0.9 | GO:0043203 | axon hillock(GO:0043203) |
| 0.0 | 0.8 | GO:0010369 | chromocenter(GO:0010369) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 4.8 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 0.8 | 4.1 | GO:0003839 | gamma-glutamylcyclotransferase activity(GO:0003839) |
| 0.9 | 2.8 | GO:0016155 | formyltetrahydrofolate dehydrogenase activity(GO:0016155) |
| 0.1 | 2.4 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.4 | 2.3 | GO:0060698 | endoribonuclease inhibitor activity(GO:0060698) |
| 0.3 | 2.3 | GO:0022858 | L-alanine transmembrane transporter activity(GO:0015180) alanine transmembrane transporter activity(GO:0022858) |
| 0.0 | 2.1 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.2 | 1.0 | GO:0045340 | mercury ion binding(GO:0045340) |
| 0.1 | 1.0 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.1 | 1.0 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 1.0 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 0.6 | PID IL5 PATHWAY | IL5-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.0 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 3.0 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 1.0 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.1 | 1.0 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |
| 0.1 | 1.0 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.0 | 0.9 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 0.6 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.0 | 0.6 | REACTOME ACTIVATION OF GENES BY ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.0 | 0.5 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.0 | 0.3 | REACTOME ACYL CHAIN REMODELLING OF PI | Genes involved in Acyl chain remodelling of PI |