ISMARA results: Creb3l2

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12D miR HR13_24

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Results for Creb3l2

Z-value: 1.68

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Transcription factors associated with Creb3l2

Gene Symbol	Gene ID	Gene Info
Creb3l2 Ensembl NCBI MGI UniProt	ENSMUSG00000038648.5	cAMP responsive element binding protein 3-like 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Creb3l2	mm10_v2_chr6_-_37442095_37442154	0.47	1.4e-01	Click!

Activity profile of Creb3l2 motif

Sorted Z-values of Creb3l2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr13_-_92131494 Show fit	4.98	ENSMUST00000099326.3 ENSMUST00000146492.1	Rasgrf2 Ensembl NCBI MGI UniProt Show fit	RAS protein-specific guanine nucleotide-releasing factor 2
chr2_+_180725263 Show fit	4.97	ENSMUST00000094218.3	Slc17a9 Ensembl NCBI MGI UniProt Show fit	solute carrier family 17, member 9
chr4_+_104766308 Show fit	3.86	ENSMUST00000031663.3	C8b Ensembl NCBI MGI UniProt Show fit	complement component 8, beta polypeptide
chr4_+_104766334 Show fit	3.77	ENSMUST00000065072.6	C8b Ensembl NCBI MGI UniProt Show fit	complement component 8, beta polypeptide
chr18_+_65800543 Show fit	3.06	ENSMUST00000025394.6 ENSMUST00000153193.1	Sec11c Ensembl NCBI MGI UniProt Show fit	SEC11 homolog C (S. cerevisiae)
chr5_-_139814231 Show fit	2.58	ENSMUST00000044002.4	Tmem184a Ensembl NCBI MGI UniProt Show fit	transmembrane protein 184a
chr2_+_160880642 Show fit	2.40	ENSMUST00000109456.2	Lpin3 Ensembl NCBI MGI UniProt Show fit	lipin 3
chr4_-_106617232 Show fit	2.23	ENSMUST00000106788.1	BC055111 Ensembl NCBI MGI UniProt Show fit	cDNA sequence BC055111
chr4_+_133553370 Show fit	2.06	ENSMUST00000042706.2	Nr0b2 Ensembl NCBI MGI UniProt Show fit	nuclear receptor subfamily 0, group B, member 2
chr14_-_70443442 Show fit	2.05	ENSMUST00000000793.5	Polr3d Ensembl NCBI MGI UniProt Show fit	polymerase (RNA) III (DNA directed) polypeptide D

Showing 1 to 10 of 184 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Creb3l2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	7.6	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.2	5.9	GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.1	5.0	GO:1903146	regulation of mitophagy(GO:1903146)
0.7	4.4	GO:0018992	germ-line sex determination(GO:0018992)
0.1	3.9	GO:0006383	transcription from RNA polymerase III promoter(GO:0006383)
0.2	3.1	GO:0006465	signal peptide processing(GO:0006465)
0.6	2.8	GO:0000738	DNA catabolic process, exonucleolytic(GO:0000738)
0.0	2.1	GO:0032024	positive regulation of insulin secretion(GO:0032024)
0.1	1.9	GO:0006817	phosphate ion transport(GO:0006817)
0.1	1.9	GO:1902175	regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902175)

Showing 1 to 10 of 67 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	7.6	GO:0005579	membrane attack complex(GO:0005579)
0.1	4.3	GO:0031901	early endosome membrane(GO:0031901)
0.2	3.9	GO:0005666	DNA-directed RNA polymerase III complex(GO:0005666)
0.4	3.1	GO:0005787	signal peptidase complex(GO:0005787)
0.1	2.8	GO:0015030	Cajal body(GO:0015030)
0.1	2.2	GO:0030127	COPII vesicle coat(GO:0030127)
0.0	1.9	GO:1990391	DNA repair complex(GO:1990391)
0.1	1.8	GO:0070971	endoplasmic reticulum exit site(GO:0070971)
0.4	1.5	GO:0097574	lateral part of cell(GO:0097574) basolateral part of cell(GO:1990794) rod bipolar cell terminal bouton(GO:1990795)
0.2	1.4	GO:0097342	ripoptosome(GO:0097342)

Showing 1 to 10 of 26 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	7.7	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2	3.9	GO:0001056	RNA polymerase III activity(GO:0001056)
0.3	2.9	GO:0031545	peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.7	2.8	GO:0008859	exoribonuclease II activity(GO:0008859)
0.0	2.2	GO:0008236	serine-type peptidase activity(GO:0008236)
0.1	2.1	GO:0042975	peroxisome proliferator activated receptor binding(GO:0042975)
0.6	1.9	GO:0015319	sodium:inorganic phosphate symporter activity(GO:0015319)
0.0	1.9	GO:0003697	single-stranded DNA binding(GO:0003697)
0.0	1.8	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0	1.7	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)

Showing 1 to 10 of 53 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	6.5	ST G ALPHA S PATHWAY	G alpha s Pathway
0.0	2.2	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.1	2.1	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.0	1.9	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.0	1.8	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.0	1.8	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.0	1.4	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.0	1.2	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
0.0	1.2	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0	1.1	ST INTEGRIN SIGNALING PATHWAY	Integrin Signaling Pathway

Showing 1 to 10 of 16 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	7.6	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
0.2	5.9	REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR	Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.2	3.9	REACTOME RNA POL III CHAIN ELONGATION	Genes involved in RNA Polymerase III Chain Elongation
0.2	3.1	REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1	2.8	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.0	1.9	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.0	1.8	REACTOME RECYCLING PATHWAY OF L1	Genes involved in Recycling pathway of L1
0.0	1.7	REACTOME G ALPHA S SIGNALLING EVENTS	Genes involved in G alpha (s) signalling events
0.0	1.6	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.0	1.5	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling

Showing 1 to 10 of 31 entries

Results for Creb3l2

Z-value: 1.68

Motif logo

Transcription factors associated with Creb3l2

Activity-expression correlation:

Activity profile of Creb3l2 motif

Sorted Z-values of Creb3l2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Creb3l2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: