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12D miR HR13_24
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Results for Elf5
Z-value: 2.18
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Transcription factors associated with Elf5
Network of associatons between targets according to the STRING database.
First level regulatory network of Elf5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.8 | GO:0038083 | peptidyl-tyrosine autophosphorylation(GO:0038083) |
| 0.2 | 7.2 | GO:0006891 | intra-Golgi vesicle-mediated transport(GO:0006891) |
| 1.2 | 6.2 | GO:1904720 | regulation of mRNA cleavage(GO:0031437) negative regulation of mRNA cleavage(GO:0031438) regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904720) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721) |
| 0.3 | 5.3 | GO:0016558 | protein import into peroxisome matrix(GO:0016558) |
| 0.3 | 4.9 | GO:0060363 | cranial suture morphogenesis(GO:0060363) |
| 0.9 | 4.6 | GO:0033277 | abortive mitotic cell cycle(GO:0033277) |
| 0.1 | 4.6 | GO:0006888 | ER to Golgi vesicle-mediated transport(GO:0006888) |
| 0.2 | 4.1 | GO:0006465 | signal peptide processing(GO:0006465) |
| 0.7 | 4.0 | GO:0032497 | detection of lipopolysaccharide(GO:0032497) |
| 0.3 | 3.8 | GO:0090110 | cargo loading into COPII-coated vesicle(GO:0090110) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 17.5 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.0 | 12.6 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.0 | 11.2 | GO:0000323 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 0.0 | 7.9 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.0 | 7.6 | GO:0005768 | endosome(GO:0005768) |
| 0.1 | 6.5 | GO:0031227 | intrinsic component of endoplasmic reticulum membrane(GO:0031227) |
| 0.0 | 5.8 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.0 | 5.6 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.0 | 5.5 | GO:0001726 | ruffle(GO:0001726) |
| 0.8 | 5.4 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.4 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.1 | 9.8 | GO:0019905 | syntaxin binding(GO:0019905) |
| 0.1 | 8.0 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.0 | 6.4 | GO:0008236 | serine-type peptidase activity(GO:0008236) |
| 1.0 | 6.2 | GO:0060698 | endoribonuclease inhibitor activity(GO:0060698) |
| 0.0 | 5.2 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.6 | 4.8 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.2 | 4.7 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.3 | 4.2 | GO:0015923 | mannosidase activity(GO:0015923) |
| 0.8 | 4.0 | GO:0001875 | lipopolysaccharide receptor activity(GO:0001875) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.9 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.0 | 7.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 6.9 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 4.3 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.1 | 4.1 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.1 | 3.3 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.1 | 3.0 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.1 | 2.7 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.0 | 2.6 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.1 | 2.5 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.4 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.4 | 8.6 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.1 | 6.3 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.2 | 5.6 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.3 | 5.0 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.1 | 4.5 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.3 | 3.8 | REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE | Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle |
| 0.3 | 3.5 | REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |
| 0.1 | 3.5 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.1 | 3.4 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |