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12D miR HR13_24
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Results for En1
Z-value: 1.57
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Transcription factors associated with En1
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr13_-_71963713 Show fit | 3.04 |
ENSMUST00000077337.8
|
Iroquois related homeobox 1 (Drosophila) |
|
| chr13_-_3945349 Show fit | 2.69 |
ENSMUST00000058610.7
|
urocortin 3 |
|
| chr1_-_158814469 Show fit | 2.67 |
ENSMUST00000161589.2
|
pappalysin 2 |
|
| chr12_-_119238794 Show fit | 2.49 |
ENSMUST00000026360.8
|
integrin beta 8 |
|
| chr4_-_131672133 Show fit | 2.12 |
ENSMUST00000144212.1
|
predicted gene 12962 |
|
| chr11_+_115154139 Show fit | 2.03 |
ENSMUST00000021076.5
|
RAB37, member of RAS oncogene family |
|
| chr7_-_101869012 Show fit | 1.91 |
ENSMUST00000123321.1
|
folate receptor 1 (adult) |
|
| chr7_-_101868667 Show fit | 1.73 |
ENSMUST00000150184.1
|
folate receptor 1 (adult) |
|
| chr9_+_46998931 Show fit | 1.69 |
ENSMUST00000178065.1
|
predicted gene 4791 |
|
| chr1_+_171155512 Show fit | 1.66 |
ENSMUST00000111334.1
|
myelin protein zero |
Network of associatons between targets according to the STRING database.
First level regulatory network of En1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 3.6 | GO:0003147 | neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713) cellular response to folic acid(GO:0071231) |
| 0.8 | 3.0 | GO:0072272 | proximal/distal pattern formation involved in metanephric nephron development(GO:0072272) |
| 0.1 | 3.0 | GO:0007189 | adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189) |
| 0.3 | 2.5 | GO:0033564 | anterior/posterior axon guidance(GO:0033564) |
| 0.8 | 2.3 | GO:0002014 | vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure(GO:0002014) |
| 0.3 | 2.2 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
| 0.1 | 2.1 | GO:0001573 | ganglioside metabolic process(GO:0001573) |
| 0.1 | 1.8 | GO:0036158 | outer dynein arm assembly(GO:0036158) |
| 0.0 | 1.8 | GO:0060349 | bone morphogenesis(GO:0060349) |
| 0.1 | 1.7 | GO:0045217 | cell-cell junction maintenance(GO:0045217) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.6 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.1 | 2.7 | GO:0043196 | varicosity(GO:0043196) |
| 0.1 | 2.6 | GO:0008305 | integrin complex(GO:0008305) |
| 0.0 | 2.0 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.1 | 1.9 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.1 | 1.5 | GO:0042582 | primary lysosome(GO:0005766) azurophil granule(GO:0042582) |
| 0.1 | 1.5 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.0 | 1.5 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) |
| 0.0 | 1.3 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.2 | 1.2 | GO:1990357 | terminal web(GO:1990357) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.2 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.3 | 3.6 | GO:0051870 | methotrexate binding(GO:0051870) |
| 0.3 | 2.7 | GO:0051429 | corticotropin-releasing hormone receptor binding(GO:0051429) |
| 0.4 | 2.5 | GO:0005042 | netrin receptor activity(GO:0005042) |
| 0.4 | 2.5 | GO:1990430 | extracellular matrix protein binding(GO:1990430) |
| 0.1 | 2.3 | GO:0047617 | acyl-CoA hydrolase activity(GO:0047617) |
| 0.0 | 2.3 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.3 | 2.2 | GO:0004013 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.1 | 1.5 | GO:0004579 | oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 0.0 | 1.5 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 2.5 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.1 | 2.1 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 1.6 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.0 | 1.2 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 1.1 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 1.0 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 0.9 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.0 | 0.9 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.0 | 0.8 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.5 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.0 | 2.5 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 2.0 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 2.0 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.1 | 1.8 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.0 | 1.6 | REACTOME TRANS GOLGI NETWORK VESICLE BUDDING | Genes involved in trans-Golgi Network Vesicle Budding |
| 0.0 | 1.0 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 0.0 | 1.0 | REACTOME L1CAM INTERACTIONS | Genes involved in L1CAM interactions |
| 0.0 | 0.9 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.1 | 0.8 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |