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12D miR HR13_24
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Results for Foxa3
Z-value: 1.55
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Transcription factors associated with Foxa3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Foxa3 | mm10_v2_chr7_-_19023538_19023546 | 0.53 | 9.1e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_104766308 Show fit | 8.31 |
ENSMUST00000031663.3
|
complement component 8, beta polypeptide |
|
| chr4_+_104766334 Show fit | 7.71 |
ENSMUST00000065072.6
|
complement component 8, beta polypeptide |
|
| chrX_-_108664891 Show fit | 6.80 |
ENSMUST00000178160.1
|
predicted gene 379 |
|
| chr3_+_138277489 Show fit | 3.64 |
ENSMUST00000004232.9
|
alcohol dehydrogenase 1 (class I) |
|
| chr13_-_95478655 Show fit | 3.32 |
ENSMUST00000022186.3
|
S100 calcium binding protein, zeta |
|
| chr2_-_62483637 Show fit | 2.87 |
ENSMUST00000136686.1
ENSMUST00000102733.3 |
glucagon |
|
| chr5_-_86906937 Show fit | 2.68 |
ENSMUST00000031181.9
ENSMUST00000113333.1 |
UDP glucuronosyltransferase 2 family, polypeptide B34 |
|
| chr3_+_106113229 Show fit | 2.33 |
ENSMUST00000079132.5
ENSMUST00000139086.1 |
chitinase, acidic |
|
| chr6_+_97991776 Show fit | 2.29 |
ENSMUST00000043628.6
|
microphthalmia-associated transcription factor |
|
| chr3_-_145032765 Show fit | 2.23 |
ENSMUST00000029919.5
|
chloride channel calcium activated 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Foxa3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 16.0 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.9 | 3.7 | GO:0006069 | ethanol oxidation(GO:0006069) |
| 0.4 | 2.9 | GO:0035948 | positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) |
| 0.0 | 2.8 | GO:0009166 | nucleotide catabolic process(GO:0009166) |
| 0.0 | 2.5 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.2 | 2.3 | GO:0044336 | canonical Wnt signaling pathway involved in negative regulation of apoptotic process(GO:0044336) |
| 0.2 | 2.2 | GO:0070842 | aggresome assembly(GO:0070842) |
| 0.4 | 1.8 | GO:0060005 | vestibular reflex(GO:0060005) |
| 0.4 | 1.8 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
| 0.4 | 1.8 | GO:0060066 | oviduct development(GO:0060066) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 16.3 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.3 | 2.8 | GO:0045098 | type III intermediate filament(GO:0045098) |
| 0.1 | 2.5 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 2.2 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.1 | 1.8 | GO:0016600 | flotillin complex(GO:0016600) lateral loop(GO:0043219) |
| 0.0 | 1.8 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.2 | 1.7 | GO:0031466 | Cul5-RING ubiquitin ligase complex(GO:0031466) |
| 0.2 | 1.4 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
| 0.2 | 1.3 | GO:1990357 | terminal web(GO:1990357) |
| 0.1 | 1.1 | GO:0033391 | chromatoid body(GO:0033391) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 19.2 | GO:0032403 | protein complex binding(GO:0032403) |
| 1.2 | 3.7 | GO:0004024 | alcohol dehydrogenase activity, zinc-dependent(GO:0004024) |
| 0.1 | 3.4 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.6 | 2.8 | GO:0004850 | uridine phosphorylase activity(GO:0004850) |
| 0.0 | 2.3 | GO:0070888 | E-box binding(GO:0070888) |
| 0.6 | 1.8 | GO:0045352 | interleukin-1, Type II receptor binding(GO:0005151) interleukin-1 receptor antagonist activity(GO:0005152) interleukin-1 Type I receptor antagonist activity(GO:0045352) interleukin-1 Type II receptor antagonist activity(GO:0045353) |
| 0.1 | 1.8 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.1 | 1.8 | GO:0001530 | lipopolysaccharide binding(GO:0001530) |
| 0.2 | 1.7 | GO:0008241 | peptidyl-dipeptidase activity(GO:0008241) |
| 0.2 | 1.7 | GO:0004556 | alpha-amylase activity(GO:0004556) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.1 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 4.2 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 3.2 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 2.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 2.1 | PID NEPHRIN NEPH1 PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.0 | 1.8 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.0 | 1.8 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.0 | 1.6 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 1.1 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 1.1 | PID AURORA A PATHWAY | Aurora A signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 13.8 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.2 | 3.3 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.2 | 2.8 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.1 | 2.0 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.0 | 1.8 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.0 | 1.4 | REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D | Genes involved in Metabolism of steroid hormones and vitamins A and D |
| 0.0 | 1.3 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 1.1 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.1 | 1.0 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.1 | 1.0 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |