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12D miR HR13_24
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Results for Foxj3_Tbl1xr1
Z-value: 1.98
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Transcription factors associated with Foxj3_Tbl1xr1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Tbl1xr1 | mm10_v2_chr3_+_22076644_22076681 | -0.83 | 1.7e-03 | Click! |
| Foxj3 | mm10_v2_chr4_+_119539652_119539698 | -0.82 | 2.0e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chrX_+_164162167 Show fit | 5.61 |
ENSMUST00000131543.1
|
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 |
|
| chr10_+_128267997 Show fit | 4.63 |
ENSMUST00000050901.2
|
apolipoprotein F |
|
| chr1_-_158814469 Show fit | 4.27 |
ENSMUST00000161589.2
|
pappalysin 2 |
|
| chr3_+_138277489 Show fit | 3.70 |
ENSMUST00000004232.9
|
alcohol dehydrogenase 1 (class I) |
|
| chr7_-_101870778 Show fit | 3.45 |
ENSMUST00000001882.4
ENSMUST00000126204.1 ENSMUST00000155311.1 ENSMUST00000106983.1 ENSMUST00000123630.1 |
folate receptor 1 (adult) |
|
| chr14_-_13914478 Show fit | 3.01 |
ENSMUST00000144914.1
|
predicted gene 281 |
|
| chr16_+_32756336 Show fit | 2.76 |
ENSMUST00000135753.1
|
mucin 4 |
|
| chr4_+_134864536 Show fit | 2.68 |
ENSMUST00000030627.7
|
Rh blood group, D antigen |
|
| chr17_+_32468462 Show fit | 2.66 |
ENSMUST00000003413.6
|
cytochrome P450, family 4, subfamily f, polypeptide 39 |
|
| chr2_-_62483637 Show fit | 2.51 |
ENSMUST00000136686.1
ENSMUST00000102733.3 |
glucagon |
Network of associatons between targets according to the STRING database.
First level regulatory network of Foxj3_Tbl1xr1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 15.5 | GO:0003147 | neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713) cellular response to folic acid(GO:0071231) |
| 0.1 | 12.4 | GO:0007608 | sensory perception of smell(GO:0007608) |
| 2.3 | 9.2 | GO:0015801 | aromatic amino acid transport(GO:0015801) tryptophan transport(GO:0015827) |
| 0.9 | 5.3 | GO:0002835 | negative regulation of response to tumor cell(GO:0002835) negative regulation of immune response to tumor cell(GO:0002838) |
| 0.2 | 5.1 | GO:0060445 | branching involved in salivary gland morphogenesis(GO:0060445) |
| 0.1 | 5.1 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.3 | 5.0 | GO:1901841 | regulation of high voltage-gated calcium channel activity(GO:1901841) |
| 0.3 | 4.9 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 1.5 | 4.4 | GO:0042853 | glycine biosynthetic process, by transamination of glyoxylate(GO:0019265) L-alanine catabolic process(GO:0042853) |
| 0.2 | 4.4 | GO:1990001 | inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 27.4 | GO:0005615 | extracellular space(GO:0005615) |
| 0.8 | 16.7 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.1 | 11.4 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.0 | 10.3 | GO:0019898 | extrinsic component of membrane(GO:0019898) |
| 0.1 | 7.7 | GO:0031227 | intrinsic component of endoplasmic reticulum membrane(GO:0031227) |
| 0.0 | 6.9 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.1 | 5.2 | GO:0030139 | endocytic vesicle(GO:0030139) |
| 0.1 | 4.5 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.4 | 4.3 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.5 | 4.1 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 15.4 | GO:0051870 | methotrexate binding(GO:0051870) |
| 0.2 | 11.2 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 1.3 | 9.2 | GO:0008241 | peptidyl-dipeptidase activity(GO:0008241) |
| 0.1 | 9.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.2 | 8.2 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.3 | 6.5 | GO:0045295 | gamma-catenin binding(GO:0045295) |
| 0.1 | 6.0 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.2 | 5.9 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.6 | 5.8 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.1 | 5.6 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 8.7 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 7.9 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 7.1 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.2 | 6.1 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.1 | 5.8 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
| 0.1 | 5.5 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.1 | 4.0 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 3.8 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.0 | 3.5 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.6 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.4 | 7.3 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.4 | 7.3 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.3 | 6.3 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 5.6 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.2 | 4.6 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.2 | 4.6 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.1 | 4.6 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 4.3 | REACTOME PHASE II CONJUGATION | Genes involved in Phase II conjugation |
| 0.1 | 4.1 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |