ISMARA results: Hey1_Myc

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12D miR HR13_24

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Results for Hey1_Myc_Mxi1

Z-value: 2.39

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Transcription factors associated with Hey1_Myc_Mxi1

Gene Symbol	Gene ID	Gene Info
Hey1 Ensembl NCBI MGI UniProt	ENSMUSG00000040289.3	hairy/enhancer-of-split related with YRPW motif 1
Myc Ensembl NCBI MGI UniProt	ENSMUSG00000022346.8	myelocytomatosis oncogene
Mxi1 Ensembl NCBI MGI UniProt	ENSMUSG00000025025.7	MAX interactor 1, dimerization protein

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Mxi1	mm10_v2_chr19_+_53310495_53310552	0.94	1.6e-05	Click!
Hey1	mm10_v2_chr3_-_8667033_8667046	0.80	3.1e-03	Click!
Myc	mm10_v2_chr15_+_61987410_61987491	0.68	2.0e-02	Click!

Activity profile of Hey1_Myc_Mxi1 motif

Sorted Z-values of Hey1_Myc_Mxi1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_+_104638658 Show fit	8.55	ENSMUST00000046212.1	Slc16a1 Ensembl NCBI MGI UniProt Show fit	solute carrier family 16 (monocarboxylic acid transporters), member 1
chr9_+_107587711 Show fit	8.16	ENSMUST00000010192.5	Ifrd2 Ensembl NCBI MGI UniProt Show fit	interferon-related developmental regulator 2
chr4_+_124657646 Show fit	7.27	ENSMUST00000053491.7	Pou3f1 Ensembl NCBI MGI UniProt Show fit	POU domain, class 3, transcription factor 1
chr7_+_141476374 Show fit	7.04	ENSMUST00000117634.1	Tspan4 Ensembl NCBI MGI UniProt Show fit	tetraspanin 4
chr2_+_164769892 Show fit	7.04	ENSMUST00000088248.6 ENSMUST00000001439.6	Ube2c Ensembl NCBI MGI UniProt Show fit	ubiquitin-conjugating enzyme E2C
chr4_+_134468320 Show fit	6.35	ENSMUST00000030636.4 ENSMUST00000127279.1 ENSMUST00000105867.1	Stmn1 Ensembl NCBI MGI UniProt Show fit	stathmin 1
chr12_+_109459843 Show fit	6.21	ENSMUST00000173812.1	Dlk1 Ensembl NCBI MGI UniProt Show fit	delta-like 1 homolog (Drosophila)
chr9_+_44066993 Show fit	5.35	ENSMUST00000034508.7	Usp2 Ensembl NCBI MGI UniProt Show fit	ubiquitin specific peptidase 2
chr17_-_24658425 Show fit	5.22	ENSMUST00000095544.4	Npw Ensembl NCBI MGI UniProt Show fit	neuropeptide W
chr2_+_130274424 Show fit	4.88	ENSMUST00000103198.4	Nop56 Ensembl NCBI MGI UniProt Show fit	NOP56 ribonucleoprotein

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Hey1_Myc_Mxi1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	12.5	GO:0000154	rRNA modification(GO:0000154)
0.6	11.4	GO:0048642	negative regulation of skeletal muscle tissue development(GO:0048642)
2.2	11.0	GO:0090521	glomerular visceral epithelial cell migration(GO:0090521)
0.3	8.8	GO:0000027	ribosomal large subunit assembly(GO:0000027)
0.9	8.6	GO:0015727	lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
1.6	8.2	GO:0018002	N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
1.3	7.8	GO:0048254	snoRNA localization(GO:0048254)
0.8	7.4	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
1.0	7.0	GO:0031536	regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994) positive regulation of exit from mitosis(GO:0031536)
0.1	6.8	GO:0006364	rRNA processing(GO:0006364)

Showing 1 to 10 of 444 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.5	17.8	GO:0031428	box C/D snoRNP complex(GO:0031428)
0.0	17.3	GO:0005813	centrosome(GO:0005813)
0.1	12.1	GO:0001650	fibrillar center(GO:0001650)
0.2	9.3	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
1.2	9.2	GO:0031415	NatA complex(GO:0031415)
0.0	8.3	GO:0005730	nucleolus(GO:0005730)
0.0	7.9	GO:0005759	mitochondrial matrix(GO:0005759)
1.6	7.8	GO:0044611	nuclear pore inner ring(GO:0044611)
0.3	7.5	GO:0030686	90S preribosome(GO:0030686)
0.1	7.4	GO:0022626	cytosolic ribosome(GO:0022626)

Showing 1 to 10 of 207 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	11.0	GO:1990226	histone methyltransferase binding(GO:1990226)
0.1	10.9	GO:0003735	structural constituent of ribosome(GO:0003735)
0.2	10.5	GO:0030332	cyclin binding(GO:0030332)
0.1	10.1	GO:0003823	antigen binding(GO:0003823)
0.3	9.9	GO:0098632	protein binding involved in cell-cell adhesion(GO:0098632)
0.2	9.7	GO:0061631	ubiquitin conjugating enzyme activity(GO:0061631)
0.0	9.3	GO:0005096	GTPase activator activity(GO:0005096)
1.1	8.9	GO:0001094	TFIID-class transcription factor binding(GO:0001094)
1.2	8.6	GO:0015129	lactate transmembrane transporter activity(GO:0015129)
1.6	8.2	GO:1990190	peptide-glutamate-N-acetyltransferase activity(GO:1990190)

Showing 1 to 10 of 314 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	17.2	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.1	6.8	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.4	6.4	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.4	6.4	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.1	5.2	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.1	4.5	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.1	4.3	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.1	3.9	PID ATR PATHWAY	ATR signaling pathway
0.0	3.9	WNT SIGNALING	Genes related to Wnt-mediated signal transduction
0.1	3.7	PID MTOR 4PATHWAY	mTOR signaling pathway

Showing 1 to 10 of 50 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	17.8	REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S	Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.2	10.1	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.1	9.9	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.7	8.7	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.2	8.4	REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY	Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.2	8.3	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.2	7.4	REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1	7.4	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.4	7.2	REACTOME PHOSPHORYLATION OF THE APC C	Genes involved in Phosphorylation of the APC/C
0.2	7.0	REACTOME GLYCOLYSIS	Genes involved in Glycolysis

Showing 1 to 10 of 93 entries

Results for Hey1_Myc_Mxi1

Z-value: 2.39

Motif logo

Transcription factors associated with Hey1_Myc_Mxi1

Activity-expression correlation:

Activity profile of Hey1_Myc_Mxi1 motif

Sorted Z-values of Hey1_Myc_Mxi1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Hey1_Myc_Mxi1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: