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12D miR HR13_24
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Results for Hoxb7
Z-value: 2.20
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Transcription factors associated with Hoxb7
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Hoxb7 | mm10_v2_chr11_+_96286623_96286653 | -0.65 | 2.9e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_102589687 Show fit | 4.82 |
ENSMUST00000097949.4
ENSMUST00000106901.1 |
phosphodiesterase 4B, cAMP specific |
|
| chr2_-_62483637 Show fit | 4.39 |
ENSMUST00000136686.1
ENSMUST00000102733.3 |
glucagon |
|
| chr13_-_18382041 Show fit | 3.96 |
ENSMUST00000139064.2
ENSMUST00000175703.2 |
POU domain, class 6, transcription factor 2 |
|
| chr8_+_54954728 Show fit | 3.93 |
ENSMUST00000033915.7
|
glycoprotein m6a |
|
| chr5_-_123141067 Show fit | 3.60 |
ENSMUST00000162697.1
ENSMUST00000160321.1 ENSMUST00000159637.1 |
expressed sequence AI480526 |
|
| chr6_+_96113146 Show fit | 3.46 |
ENSMUST00000122120.1
|
family with sequence similarity 19, member A1 |
|
| chr13_-_3945349 Show fit | 3.04 |
ENSMUST00000058610.7
|
urocortin 3 |
|
| chr14_-_110755100 Show fit | 2.84 |
ENSMUST00000078386.2
|
SLIT and NTRK-like family, member 6 |
|
| chr17_-_90088343 Show fit | 2.78 |
ENSMUST00000173917.1
|
neurexin I |
|
| chr8_-_38661508 Show fit | 2.66 |
ENSMUST00000118896.1
|
sarcoglycan zeta |
Network of associatons between targets according to the STRING database.
First level regulatory network of Hoxb7
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 7.3 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
| 0.7 | 6.5 | GO:0010908 | regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) |
| 0.5 | 6.0 | GO:1901898 | negative regulation of relaxation of cardiac muscle(GO:1901898) |
| 0.5 | 5.9 | GO:0070842 | aggresome assembly(GO:0070842) |
| 0.6 | 5.0 | GO:0035887 | aortic smooth muscle cell differentiation(GO:0035887) |
| 0.1 | 4.8 | GO:0042462 | eye photoreceptor cell development(GO:0042462) |
| 1.5 | 4.6 | GO:0050973 | detection of mechanical stimulus involved in equilibrioception(GO:0050973) |
| 0.6 | 4.4 | GO:0035948 | positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) |
| 0.6 | 4.2 | GO:0048852 | diencephalon morphogenesis(GO:0048852) |
| 0.0 | 4.0 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.9 | GO:0030426 | growth cone(GO:0030426) |
| 0.3 | 7.4 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.1 | 7.0 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.7 | 6.5 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) |
| 0.1 | 6.4 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.0 | 6.4 | GO:0097060 | synaptic membrane(GO:0097060) |
| 0.4 | 6.2 | GO:0036057 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.2 | 6.2 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.3 | 5.0 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.1 | 4.7 | GO:0044295 | axonal growth cone(GO:0044295) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 7.3 | GO:0016802 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.2 | 6.8 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.0 | 6.1 | GO:0047485 | protein N-terminus binding(GO:0047485) |
| 0.2 | 5.4 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.2 | 5.1 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.1 | 4.7 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.0 | 4.7 | GO:0005262 | calcium channel activity(GO:0005262) |
| 0.1 | 4.6 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.0 | 4.5 | GO:0004386 | helicase activity(GO:0004386) |
| 0.0 | 4.1 | GO:0005179 | hormone activity(GO:0005179) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.3 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 5.4 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.2 | 5.1 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.1 | 5.0 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 4.2 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 4.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 3.8 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.1 | 3.3 | PID FGF PATHWAY | FGF signaling pathway |
| 0.1 | 1.8 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.1 | 1.7 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.6 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.3 | 6.9 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 | Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1) |
| 0.2 | 6.9 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.2 | 4.8 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.1 | 4.4 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
| 0.2 | 3.8 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 3.7 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.0 | 3.1 | REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
| 0.2 | 2.9 | REACTOME FGFR4 LIGAND BINDING AND ACTIVATION | Genes involved in FGFR4 ligand binding and activation |
| 0.2 | 2.9 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |