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12D miR HR13_24
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Results for Hsf2
Z-value: 1.29
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Transcription factors associated with Hsf2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Hsf2 | mm10_v2_chr10_+_57486354_57486414 | 0.40 | 2.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Hsf2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 3.9 | GO:0060523 | prostate epithelial cord elongation(GO:0060523) |
| 0.1 | 2.0 | GO:0033235 | positive regulation of protein sumoylation(GO:0033235) |
| 0.5 | 1.6 | GO:0002842 | positive regulation of T cell mediated immune response to tumor cell(GO:0002842) protein import into mitochondrial intermembrane space(GO:0045041) |
| 0.3 | 1.5 | GO:0045585 | regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585) |
| 0.1 | 1.3 | GO:0060081 | membrane hyperpolarization(GO:0060081) |
| 0.1 | 1.1 | GO:0060371 | regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371) |
| 0.1 | 1.1 | GO:0071285 | cellular response to lithium ion(GO:0071285) |
| 0.1 | 1.1 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
| 0.0 | 1.1 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 0.1 | 1.0 | GO:1903405 | protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) protein localization to nucleoplasm(GO:1990173) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 3.9 | GO:0097550 | transcriptional preinitiation complex(GO:0097550) |
| 0.0 | 2.2 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.1 | 1.7 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.2 | 1.6 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.3 | 1.5 | GO:0097226 | sperm mitochondrial sheath(GO:0097226) |
| 0.0 | 1.5 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.2 | 1.4 | GO:0005818 | aster(GO:0005818) |
| 0.1 | 1.1 | GO:0030061 | mitochondrial crista(GO:0030061) |
| 0.1 | 1.1 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.2 | 1.0 | GO:0031314 | extrinsic component of mitochondrial inner membrane(GO:0031314) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 3.9 | GO:0031798 | type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052) |
| 0.0 | 2.6 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.2 | 2.4 | GO:0008474 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.1 | 2.0 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
| 0.3 | 1.7 | GO:0002135 | CTP binding(GO:0002135) |
| 0.0 | 1.7 | GO:0030506 | ankyrin binding(GO:0030506) |
| 0.2 | 1.6 | GO:0043559 | insulin binding(GO:0043559) |
| 0.0 | 1.6 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.4 | 1.5 | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575) |
| 0.2 | 1.4 | GO:0061676 | importin-alpha family protein binding(GO:0061676) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.8 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.0 | 2.4 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 2.1 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.0 | 2.1 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 1.7 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 1.5 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 1.2 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.0 | 1.1 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 1.0 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 0.9 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.1 | REACTOME NUCLEAR SIGNALING BY ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
| 0.0 | 2.5 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 2.1 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 1.7 | REACTOME SEMA3A PAK DEPENDENT AXON REPULSION | Genes involved in Sema3A PAK dependent Axon repulsion |
| 0.0 | 1.7 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.0 | 1.2 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.0 | 1.2 | REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |
| 0.0 | 1.1 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 1.0 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.0 | 1.0 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |