ISMARA results: Irf2_Irf1_Irf8_Irf9

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12D miR HR13_24

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Results for Irf2_Irf1_Irf8_Irf9_Irf7

Z-value: 2.09

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Transcription factors associated with Irf2_Irf1_Irf8_Irf9_Irf7

Gene Symbol	Gene ID	Gene Info
Irf2 Ensembl NCBI MGI UniProt	ENSMUSG00000031627.7	interferon regulatory factor 2
Irf1 Ensembl NCBI MGI UniProt	ENSMUSG00000018899.10	interferon regulatory factor 1
Irf8 Ensembl NCBI MGI UniProt	ENSMUSG00000041515.3	interferon regulatory factor 8
Irf9 Ensembl NCBI MGI UniProt	ENSMUSG00000002325.8	interferon regulatory factor 9
Irf7 Ensembl NCBI MGI UniProt	ENSMUSG00000025498.8	interferon regulatory factor 7

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Irf2	mm10_v2_chr8_+_46739745_46739791	-0.80	2.8e-03	Click!
Irf8	mm10_v2_chr8_+_120736352_120736385	-0.52	1.0e-01	Click!
Irf1	mm10_v2_chr11_+_53770458_53770509	-0.46	1.5e-01	Click!
Irf9	mm10_v2_chr14_+_55604550_55604579	-0.34	3.0e-01	Click!
Irf7	mm10_v2_chr7_-_141266415_141266481	-0.00	9.9e-01	Click!

Activity profile of Irf2_Irf1_Irf8_Irf9_Irf7 motif

Sorted Z-values of Irf2_Irf1_Irf8_Irf9_Irf7 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr8_+_61928081 Show fit	5.73	ENSMUST00000154398.1 ENSMUST00000093485.2 ENSMUST00000156980.1 ENSMUST00000070631.7	Ddx60 Ensembl NCBI MGI UniProt Show fit	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr3_-_113574242 Show fit	4.62	ENSMUST00000142505.2	Amy1 Ensembl NCBI MGI UniProt Show fit	amylase 1, salivary
chr3_-_113574758 Show fit	4.12	ENSMUST00000106540.1	Amy1 Ensembl NCBI MGI UniProt Show fit	amylase 1, salivary
chr7_+_104244496 Show fit	3.79	ENSMUST00000106854.1 ENSMUST00000143414.1	Trim34a Ensembl NCBI MGI UniProt Show fit	tripartite motif-containing 34A
chr7_+_104244449 Show fit	3.78	ENSMUST00000106849.2 ENSMUST00000060315.5	Trim34a Ensembl NCBI MGI UniProt Show fit	tripartite motif-containing 34A
chr7_+_104244465 Show fit	3.61	ENSMUST00000106848.1	Trim34a Ensembl NCBI MGI UniProt Show fit	tripartite motif-containing 34A
chr19_+_34640871 Show fit	3.47	ENSMUST00000102824.3	Ifit1 Ensembl NCBI MGI UniProt Show fit	interferon-induced protein with tetratricopeptide repeats 1
chr12_-_79007276 Show fit	3.45	ENSMUST00000056660.6 ENSMUST00000174721.1	Tmem229b Ensembl NCBI MGI UniProt Show fit	transmembrane protein 229B
chr5_-_92348871 Show fit	2.94	ENSMUST00000038816.6 ENSMUST00000118006.1	Cxcl10 Ensembl NCBI MGI UniProt Show fit	chemokine (C-X-C motif) ligand 10
chr8_-_105938384 Show fit	2.75	ENSMUST00000034369.8	Psmb10 Ensembl NCBI MGI UniProt Show fit	proteasome (prosome, macropain) subunit, beta type 10

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Irf2_Irf1_Irf8_Irf9_Irf7

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	17.0	GO:0042832	defense response to protozoan(GO:0042832)
0.1	9.4	GO:0016052	carbohydrate catabolic process(GO:0016052)
0.1	8.5	GO:0051607	defense response to virus(GO:0051607)
2.2	6.5	GO:1900245	positive regulation of MDA-5 signaling pathway(GO:1900245)
0.5	5.5	GO:0019885	antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.8	5.0	GO:0035546	interferon-beta secretion(GO:0035546) regulation of interferon-beta secretion(GO:0035547) positive regulation of interferon-beta secretion(GO:0035549)
1.0	3.8	GO:1901740	negative regulation of myoblast fusion(GO:1901740)
0.8	3.8	GO:0000738	DNA catabolic process, exonucleolytic(GO:0000738)
0.3	3.7	GO:0035457	cellular response to interferon-alpha(GO:0035457)
0.1	2.8	GO:0006687	glycosphingolipid metabolic process(GO:0006687)

Showing 1 to 10 of 256 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	11.1	GO:0020003	symbiont-containing vacuole(GO:0020003)
0.0	5.3	GO:0045111	intermediate filament cytoskeleton(GO:0045111)
0.0	4.9	GO:0005923	bicellular tight junction(GO:0005923)
0.8	4.2	GO:1990111	spermatoproteasome complex(GO:1990111)
0.0	3.8	GO:0016363	nuclear matrix(GO:0016363)
0.3	3.3	GO:0042612	MHC class I protein complex(GO:0042612)
0.4	3.0	GO:0042825	TAP complex(GO:0042825)
0.0	2.4	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.1	2.2	GO:0055038	recycling endosome membrane(GO:0055038)
0.1	2.1	GO:0044754	autolysosome(GO:0044754)

Showing 1 to 10 of 87 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	9.4	GO:0003924	GTPase activity(GO:0003924)
1.2	8.7	GO:0004556	alpha-amylase activity(GO:0004556)
0.1	8.0	GO:0003725	double-stranded RNA binding(GO:0003725)
0.0	5.1	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.5	4.9	GO:0001730	2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.3	4.1	GO:0050700	CARD domain binding(GO:0050700)
0.9	3.8	GO:0008859	exoribonuclease II activity(GO:0008859)
0.4	3.0	GO:0046978	TAP1 binding(GO:0046978) TAP2 binding(GO:0046979)
0.6	2.9	GO:0048248	CXCR3 chemokine receptor binding(GO:0048248)
0.1	2.9	GO:0048020	CCR chemokine receptor binding(GO:0048020)

Showing 1 to 10 of 164 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	6.4	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.3	3.0	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.1	2.9	ST G ALPHA S PATHWAY	G alpha s Pathway
0.0	2.8	PID CXCR3 PATHWAY	CXCR3-mediated signaling events
0.0	2.6	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	2.1	SIG PIP3 SIGNALING IN CARDIAC MYOCTES	Genes related to PIP3 signaling in cardiac myocytes
0.1	2.0	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.0	1.9	PID IL4 2PATHWAY	IL4-mediated signaling events
0.1	1.7	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.1	1.6	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Showing 1 to 10 of 48 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	14.5	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.3	5.6	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway
0.1	3.3	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.1	2.5	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.2	2.4	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.2	2.3	REACTOME PD1 SIGNALING	Genes involved in PD-1 signaling
0.2	2.2	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.1	2.2	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.2	2.1	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.1	2.0	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins

Showing 1 to 10 of 64 entries

Results for Irf2_Irf1_Irf8_Irf9_Irf7

Z-value: 2.09

Motif logo

Transcription factors associated with Irf2_Irf1_Irf8_Irf9_Irf7

Activity-expression correlation:

Activity profile of Irf2_Irf1_Irf8_Irf9_Irf7 motif

Sorted Z-values of Irf2_Irf1_Irf8_Irf9_Irf7 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Irf2_Irf1_Irf8_Irf9_Irf7

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: