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12D miR HR13_24
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Results for Rfx2_Rfx7
Z-value: 1.59
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Transcription factors associated with Rfx2_Rfx7
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Rfx2 | mm10_v2_chr17_-_56830916_56831008 | 0.36 | 2.8e-01 | Click! |
| Rfx7 | mm10_v2_chr9_+_72532609_72532828 | 0.11 | 7.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_-_28466266 Show fit | 3.16 |
ENSMUST00000127683.1
ENSMUST00000086370.4 |
RIKEN cDNA 1700007K13 gene |
|
| chr4_+_129960760 Show fit | 2.36 |
ENSMUST00000139884.1
|
RIKEN cDNA 1700003M07 gene |
|
| chr2_-_152831665 Show fit | 1.63 |
ENSMUST00000156688.1
ENSMUST00000007803.5 |
BCL2-like 1 |
|
| chr4_-_126325641 Show fit | 1.42 |
ENSMUST00000131113.1
|
tektin 2 |
|
| chr11_+_117523526 Show fit | 1.36 |
ENSMUST00000132261.1
|
predicted gene 11734 |
|
| chr2_-_152831112 Show fit | 1.30 |
ENSMUST00000128172.1
|
BCL2-like 1 |
|
| chr3_+_156562141 Show fit | 1.29 |
ENSMUST00000175773.1
|
neuronal growth regulator 1 |
|
| chr2_-_181698433 Show fit | 1.20 |
ENSMUST00000052416.3
|
RIKEN cDNA 4930526D03 gene |
|
| chr17_+_24696234 Show fit | 1.17 |
ENSMUST00000019464.7
|
NADPH oxidase organizer 1 |
|
| chrX_+_52791179 Show fit | 1.14 |
ENSMUST00000101588.1
|
coiled-coil domain containing 160 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Rfx2_Rfx7
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.5 | GO:0036159 | inner dynein arm assembly(GO:0036159) |
| 0.7 | 2.9 | GO:0046898 | response to cycloheximide(GO:0046898) |
| 0.0 | 2.1 | GO:0007631 | feeding behavior(GO:0007631) |
| 0.2 | 1.7 | GO:0008063 | Toll signaling pathway(GO:0008063) |
| 0.0 | 1.6 | GO:0022617 | extracellular matrix disassembly(GO:0022617) |
| 0.1 | 1.2 | GO:0036158 | outer dynein arm assembly(GO:0036158) |
| 0.1 | 1.1 | GO:0086023 | adrenergic receptor signaling pathway involved in heart process(GO:0086023) |
| 0.0 | 0.9 | GO:0003341 | cilium movement(GO:0003341) |
| 0.0 | 0.9 | GO:0006687 | glycosphingolipid metabolic process(GO:0006687) |
| 0.2 | 0.8 | GO:0060447 | bud outgrowth involved in lung branching(GO:0060447) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 2.9 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
| 0.0 | 2.6 | GO:0031514 | motile cilium(GO:0031514) |
| 0.1 | 1.7 | GO:0035631 | CD40 receptor complex(GO:0035631) |
| 0.1 | 1.2 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.0 | 1.2 | GO:0005930 | axoneme(GO:0005930) |
| 0.1 | 0.9 | GO:0033503 | HULC complex(GO:0033503) |
| 0.1 | 0.8 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.1 | 0.7 | GO:0002177 | manchette(GO:0002177) |
| 0.1 | 0.6 | GO:0036156 | inner dynein arm(GO:0036156) |
| 0.0 | 0.6 | GO:0060170 | ciliary membrane(GO:0060170) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 2.9 | GO:0051434 | BH3 domain binding(GO:0051434) |
| 0.1 | 1.6 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.0 | 1.5 | GO:0045503 | dynein light chain binding(GO:0045503) |
| 0.1 | 1.2 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 0.2 | 1.1 | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity(GO:0004726) |
| 0.0 | 0.9 | GO:0070840 | dynein complex binding(GO:0070840) |
| 0.0 | 0.9 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.0 | 0.9 | GO:0030276 | clathrin binding(GO:0030276) |
| 0.1 | 0.8 | GO:0005432 | calcium:sodium antiporter activity(GO:0005432) |
| 0.1 | 0.8 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.0 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 2.0 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.0 | 1.2 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 0.8 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 0.8 | PID THROMBIN PAR1 PATHWAY | PAR1-mediated thrombin signaling events |
| 0.0 | 0.8 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.0 | 0.6 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 0.6 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 0.4 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.0 | 0.2 | PID ALK2 PATHWAY | ALK2 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.9 | REACTOME INFLAMMASOMES | Genes involved in Inflammasomes |
| 0.1 | 1.7 | REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON | Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
| 0.0 | 1.2 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.0 | 0.5 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 0.5 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.0 | 0.4 | REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.0 | 0.4 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.0 | 0.3 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.0 | 0.1 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |