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12D miR HR13_24
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Results for Rfx3_Rfx1_Rfx4
Z-value: 2.36
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Transcription factors associated with Rfx3_Rfx1_Rfx4
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSMUSG00000040929.10 | regulatory factor X, 3 (influences HLA class II expression) | |
| ENSMUSG00000031706.6 | regulatory factor X, 1 (influences HLA class II expression) | |
| ENSMUSG00000020037.9 | regulatory factor X, 4 (influences HLA class II expression) |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Rfx1 | mm10_v2_chr8_+_84066824_84066882 | 0.90 | 1.9e-04 | Click! |
| Rfx3 | mm10_v2_chr19_-_28011138_28011181 | 0.63 | 3.9e-02 | Click! |
| Rfx4 | mm10_v2_chr10_+_84838143_84838153 | 0.28 | 4.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr18_+_60925612 Show fit | 7.59 |
ENSMUST00000102888.3
ENSMUST00000025519.4 |
calcium/calmodulin-dependent protein kinase II alpha |
|
| chr11_-_6606053 Show fit | 3.21 |
ENSMUST00000045713.3
|
NAC alpha domain containing |
|
| chr10_-_81472859 Show fit | 2.79 |
ENSMUST00000147524.1
ENSMUST00000119060.1 |
CUGBP, Elav-like family member 5 |
|
| chr7_+_126847908 Show fit | 2.64 |
ENSMUST00000147257.1
ENSMUST00000139174.1 |
double C2, alpha |
|
| chr4_+_129960760 Show fit | 2.58 |
ENSMUST00000139884.1
|
RIKEN cDNA 1700003M07 gene |
|
| chr15_+_98167806 Show fit | 2.53 |
ENSMUST00000031914.4
|
expressed sequence AI836003 |
|
| chr11_-_97352016 Show fit | 2.37 |
ENSMUST00000093942.4
|
G protein-coupled receptor 179 |
|
| chr5_+_30711849 Show fit | 2.17 |
ENSMUST00000088081.4
ENSMUST00000101442.3 |
dihydropyrimidinase-like 5 |
|
| chr5_+_30711564 Show fit | 2.16 |
ENSMUST00000114729.1
|
dihydropyrimidinase-like 5 |
|
| chr2_+_163506808 Show fit | 2.10 |
ENSMUST00000143911.1
|
hepatic nuclear factor 4, alpha |
Network of associatons between targets according to the STRING database.
First level regulatory network of Rfx3_Rfx1_Rfx4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 9.3 | GO:0098970 | receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628) |
| 0.0 | 3.9 | GO:0018107 | peptidyl-threonine phosphorylation(GO:0018107) |
| 0.1 | 3.7 | GO:0032469 | endoplasmic reticulum calcium ion homeostasis(GO:0032469) |
| 0.2 | 3.4 | GO:0048642 | negative regulation of skeletal muscle tissue development(GO:0048642) |
| 0.1 | 2.8 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.2 | 2.7 | GO:0006744 | ubiquinone biosynthetic process(GO:0006744) |
| 0.9 | 2.6 | GO:1990046 | positive regulation of mitochondrial DNA replication(GO:0090297) regulation of cardiolipin metabolic process(GO:1900208) positive regulation of cardiolipin metabolic process(GO:1900210) stress-induced mitochondrial fusion(GO:1990046) |
| 0.0 | 2.4 | GO:0007411 | axon guidance(GO:0007411) |
| 0.3 | 2.2 | GO:0034316 | negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) |
| 0.7 | 2.1 | GO:0010534 | regulation of activation of JAK2 kinase activity(GO:0010534) activation of JAK2 kinase activity(GO:0042977) negative regulation of activation of JAK2 kinase activity(GO:1902569) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.9 | GO:0005874 | microtubule(GO:0005874) |
| 1.9 | 7.6 | GO:0099522 | region of cytosol(GO:0099522) postsynaptic cytosol(GO:0099524) |
| 0.0 | 6.7 | GO:0030425 | dendrite(GO:0030425) |
| 0.0 | 3.7 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 3.7 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.1 | 2.6 | GO:0042101 | T cell receptor complex(GO:0042101) |
| 0.1 | 2.5 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.2 | 2.3 | GO:0097539 | ciliary transition fiber(GO:0097539) |
| 0.7 | 2.2 | GO:0098842 | postsynaptic early endosome(GO:0098842) |
| 0.0 | 2.1 | GO:0022626 | cytosolic ribosome(GO:0022626) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.6 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.7 | 7.8 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
| 0.0 | 4.3 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 3.8 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.1 | 3.7 | GO:0097602 | cullin family protein binding(GO:0097602) |
| 0.1 | 3.3 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.3 | 2.6 | GO:1901612 | cardiolipin binding(GO:1901612) |
| 0.1 | 2.4 | GO:0008569 | ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) |
| 0.1 | 2.3 | GO:0071949 | FAD binding(GO:0071949) |
| 0.0 | 2.2 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 7.6 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.1 | 3.2 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 3.1 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 2.0 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 1.4 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.0 | 1.0 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.0 | 0.9 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.0 | 0.9 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 0.8 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 0.7 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 7.6 | REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
| 0.2 | 4.3 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.1 | 2.7 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.1 | 2.3 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.1 | 2.2 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.0 | 1.9 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |
| 0.0 | 1.8 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.0 | 1.6 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.0 | 1.6 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.1 | 1.4 | REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A | Genes involved in APC-Cdc20 mediated degradation of Nek2A |