ISMARA results: Runx2

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12D miR HR13_24

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Results for Runx2_Bcl11a

Z-value: 1.41

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Transcription factors associated with Runx2_Bcl11a

Gene Symbol	Gene ID	Gene Info
Runx2 Ensembl NCBI MGI UniProt	ENSMUSG00000039153.10	runt related transcription factor 2
Bcl11a Ensembl NCBI MGI UniProt	ENSMUSG00000000861.9	B cell CLL/lymphoma 11A (zinc finger protein)

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Bcl11a	mm10_v2_chr11_+_24078173_24078219	-0.86	7.3e-04	Click!
Runx2	mm10_v2_chr17_-_44814581_44814595	-0.65	3.0e-02	Click!

Activity profile of Runx2_Bcl11a motif

Sorted Z-values of Runx2_Bcl11a motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr16_-_17838173 Show fit	2.92	ENSMUST00000118960.1	Car15 Ensembl NCBI MGI UniProt Show fit	carbonic anhydrase 15
chr8_-_109579056 Show fit	2.76	ENSMUST00000074898.6	Hp Ensembl NCBI MGI UniProt Show fit	haptoglobin
chr13_+_89540636 Show fit	2.66	ENSMUST00000022108.7	Hapln1 Ensembl NCBI MGI UniProt Show fit	hyaluronan and proteoglycan link protein 1
chr2_+_21367532 Show fit	2.56	ENSMUST00000055946.7	Gpr158 Ensembl NCBI MGI UniProt Show fit	G protein-coupled receptor 158
chr4_-_57916283 Show fit	2.36	ENSMUST00000063816.5	D630039A03Rik Ensembl NCBI MGI UniProt Show fit	RIKEN cDNA D630039A03 gene
chr7_+_121865070 Show fit	2.28	ENSMUST00000033161.5	Scnn1b Ensembl NCBI MGI UniProt Show fit	sodium channel, nonvoltage-gated 1 beta
chr10_-_81291227 Show fit	2.20	ENSMUST00000045744.6	Tjp3 Ensembl NCBI MGI UniProt Show fit	tight junction protein 3
chr3_-_90514250 Show fit	2.16	ENSMUST00000107340.1 ENSMUST00000060738.8	S100a1 Ensembl NCBI MGI UniProt Show fit	S100 calcium binding protein A1
chr3_+_28697901 Show fit	2.13	ENSMUST00000029240.7	Slc2a2 Ensembl NCBI MGI UniProt Show fit	solute carrier family 2 (facilitated glucose transporter), member 2
chr15_-_75567176 Show fit	2.10	ENSMUST00000156032.1 ENSMUST00000127095.1	Ly6h Ensembl NCBI MGI UniProt Show fit	lymphocyte antigen 6 complex, locus H

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Runx2_Bcl11a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	2.6	GO:2000295	regulation of hydrogen peroxide catabolic process(GO:2000295)
0.3	2.4	GO:0009449	gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.0	2.4	GO:0007608	sensory perception of smell(GO:0007608)
0.3	2.3	GO:0071896	protein localization to adherens junction(GO:0071896)
0.3	2.3	GO:0030886	negative regulation of myeloid dendritic cell activation(GO:0030886)
0.2	2.3	GO:1901387	positive regulation of voltage-gated calcium channel activity(GO:1901387)
0.4	2.1	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.1	2.1	GO:0035313	wound healing, spreading of epidermal cells(GO:0035313)
0.3	2.0	GO:0071985	multivesicular body sorting pathway(GO:0071985)
0.3	2.0	GO:0015074	DNA integration(GO:0015074)

Showing 1 to 10 of 286 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.2	GO:0046658	anchored component of plasma membrane(GO:0046658)
0.1	3.9	GO:0048786	presynaptic active zone(GO:0048786)
0.2	2.9	GO:0001533	cornified envelope(GO:0001533)
0.1	2.4	GO:0031430	M band(GO:0031430)
0.1	2.3	GO:0034706	sodium channel complex(GO:0034706)
0.2	2.1	GO:0030126	COPI vesicle coat(GO:0030126)
0.0	2.0	GO:0031225	anchored component of membrane(GO:0031225)
0.1	1.9	GO:0034663	endoplasmic reticulum chaperone complex(GO:0034663)
0.0	1.7	GO:0005923	bicellular tight junction(GO:0005923)
0.0	1.5	GO:0055037	recycling endosome(GO:0055037)

Showing 1 to 10 of 104 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	2.9	GO:0015280	ligand-gated sodium channel activity(GO:0015280)
0.1	2.9	GO:0005540	hyaluronic acid binding(GO:0005540)
0.0	2.9	GO:0004984	olfactory receptor activity(GO:0004984)
0.3	2.4	GO:0004351	glutamate decarboxylase activity(GO:0004351)
0.1	2.4	GO:0005035	tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.1	2.3	GO:0004089	carbonate dehydratase activity(GO:0004089)
0.0	2.2	GO:0005080	protein kinase C binding(GO:0005080)
0.4	2.1	GO:0055056	dehydroascorbic acid transporter activity(GO:0033300) D-glucose transmembrane transporter activity(GO:0055056)
0.3	2.1	GO:0030550	acetylcholine receptor inhibitor activity(GO:0030550)
0.1	1.7	GO:0050811	GABA receptor binding(GO:0050811)

Showing 1 to 10 of 197 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.2	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.0	2.3	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.0	1.8	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.0	1.7	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.0	1.6	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.0	1.4	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.0	1.2	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.0	1.2	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.0	1.1	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.0	1.1	PID HES HEY PATHWAY	Notch-mediated HES/HEY network

Showing 1 to 10 of 38 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	2.5	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1	2.3	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
0.1	2.0	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.0	1.9	REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS	Genes involved in Class A/1 (Rhodopsin-like receptors)
0.0	1.8	REACTOME EGFR DOWNREGULATION	Genes involved in EGFR downregulation
0.0	1.4	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.1	1.3	REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0	1.1	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.0	1.1	REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS	Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.0	1.1	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels

Showing 1 to 10 of 63 entries

Results for Runx2_Bcl11a

Z-value: 1.41

Motif logo

Transcription factors associated with Runx2_Bcl11a

Activity-expression correlation:

Activity profile of Runx2_Bcl11a motif

Sorted Z-values of Runx2_Bcl11a motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Runx2_Bcl11a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: