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12D miR HR13_24
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Results for Srf
Z-value: 1.39
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Transcription factors associated with Srf
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Srf | mm10_v2_chr17_-_46556158_46556188 | 0.82 | 1.9e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_+_14863495 Show fit | 4.03 |
ENSMUST00000029076.4
|
carbonic anhydrase 3 |
|
| chr6_-_85513586 Show fit | 3.79 |
ENSMUST00000095759.3
|
early growth response 4 |
|
| chr18_+_34861200 Show fit | 3.43 |
ENSMUST00000165033.1
|
early growth response 1 |
|
| chr6_-_83536215 Show fit | 3.03 |
ENSMUST00000075161.5
|
actin, gamma 2, smooth muscle, enteric |
|
| chr1_-_43163891 Show fit | 2.86 |
ENSMUST00000008280.7
|
four and a half LIM domains 2 |
|
| chr2_+_127336152 Show fit | 2.74 |
ENSMUST00000028846.6
|
dual specificity phosphatase 2 |
|
| chr14_+_3652030 Show fit | 2.47 |
ENSMUST00000167430.1
|
predicted gene 3020 |
|
| chr14_+_4334763 Show fit | 2.42 |
ENSMUST00000165466.1
|
RIKEN cDNA 2610042L04 gene |
|
| chr14_+_3412614 Show fit | 2.38 |
ENSMUST00000170123.1
|
predicted gene 10409 |
|
| chr2_+_156775409 Show fit | 2.32 |
ENSMUST00000088552.6
|
myosin, light polypeptide 9, regulatory |
Network of associatons between targets according to the STRING database.
First level regulatory network of Srf
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.0 | GO:0006730 | one-carbon metabolic process(GO:0006730) |
| 1.1 | 3.4 | GO:0042222 | interleukin-1 biosynthetic process(GO:0042222) positive regulation of metanephric glomerulus development(GO:0072300) |
| 0.2 | 2.9 | GO:0055015 | ventricular cardiac muscle cell development(GO:0055015) |
| 0.0 | 2.9 | GO:0070527 | platelet aggregation(GO:0070527) |
| 0.6 | 2.4 | GO:0060025 | regulation of synaptic activity(GO:0060025) |
| 0.2 | 1.6 | GO:0035902 | response to immobilization stress(GO:0035902) |
| 0.1 | 1.5 | GO:0090266 | regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504) |
| 0.2 | 1.4 | GO:0006083 | acetate metabolic process(GO:0006083) |
| 0.0 | 1.4 | GO:0001706 | endoderm formation(GO:0001706) |
| 0.4 | 1.3 | GO:1900275 | negative regulation of phospholipase C activity(GO:1900275) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.1 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.1 | 2.9 | GO:0031430 | M band(GO:0031430) |
| 0.1 | 1.9 | GO:0016460 | myosin II complex(GO:0016460) |
| 0.0 | 1.7 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 1.5 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.2 | 1.2 | GO:0097226 | sperm mitochondrial sheath(GO:0097226) |
| 0.1 | 1.2 | GO:1990357 | terminal web(GO:1990357) |
| 0.1 | 1.0 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.1 | 0.9 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.1 | 0.9 | GO:0031466 | Cul5-RING ubiquitin ligase complex(GO:0031466) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.0 | GO:0016151 | nickel cation binding(GO:0016151) |
| 0.5 | 3.4 | GO:0044729 | hemi-methylated DNA-binding(GO:0044729) |
| 0.1 | 2.3 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.0 | 2.3 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
| 0.5 | 1.6 | GO:0052596 | tryptamine:oxygen oxidoreductase (deaminating) activity(GO:0052593) aminoacetone:oxygen oxidoreductase(deaminating) activity(GO:0052594) aliphatic-amine oxidase activity(GO:0052595) phenethylamine:oxygen oxidoreductase (deaminating) activity(GO:0052596) |
| 0.0 | 1.6 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.5 | 1.4 | GO:0019807 | aspartoacylase activity(GO:0019807) |
| 0.1 | 1.4 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.2 | 1.3 | GO:0033743 | peptide-methionine (R)-S-oxide reductase activity(GO:0033743) |
| 0.1 | 1.3 | GO:0070097 | delta-catenin binding(GO:0070097) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.7 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.1 | 3.6 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 2.9 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 2.3 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 1.3 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.1 | 1.2 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 0.6 | PID RHOA PATHWAY | RhoA signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.8 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 4.3 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.1 | 2.9 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 1.3 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 1.2 | REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.0 | 0.9 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.0 | 0.5 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.0 | 0.5 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.1 | 0.4 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.0 | 0.4 | REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |