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12D miR HR13_24
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Results for Stat2
Z-value: 1.87
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Transcription factors associated with Stat2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Stat2 | mm10_v2_chr10_+_128270546_128270577 | 0.57 | 6.9e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Stat2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.9 | GO:0051607 | defense response to virus(GO:0051607) |
| 1.5 | 4.6 | GO:1900245 | positive regulation of MDA-5 signaling pathway(GO:1900245) |
| 0.7 | 4.5 | GO:0018992 | germ-line sex determination(GO:0018992) |
| 1.0 | 3.9 | GO:0006556 | S-adenosylmethionine biosynthetic process(GO:0006556) |
| 0.8 | 3.9 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 0.1 | 3.5 | GO:0010107 | potassium ion import(GO:0010107) |
| 0.4 | 3.0 | GO:0019885 | antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885) |
| 0.9 | 2.8 | GO:0009138 | dUDP biosynthetic process(GO:0006227) pyrimidine nucleoside diphosphate metabolic process(GO:0009138) pyrimidine nucleoside diphosphate biosynthetic process(GO:0009139) pyrimidine deoxyribonucleoside diphosphate metabolic process(GO:0009196) pyrimidine deoxyribonucleoside diphosphate biosynthetic process(GO:0009197) dUDP metabolic process(GO:0046077) |
| 0.1 | 2.8 | GO:0044406 | adhesion of symbiont to host(GO:0044406) |
| 0.7 | 2.6 | GO:0002415 | immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.7 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.3 | 4.5 | GO:0020003 | symbiont-containing vacuole(GO:0020003) |
| 0.1 | 4.4 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.0 | 4.1 | GO:0030315 | T-tubule(GO:0030315) |
| 0.0 | 4.1 | GO:0045111 | intermediate filament cytoskeleton(GO:0045111) |
| 0.1 | 3.9 | GO:0015030 | Cajal body(GO:0015030) |
| 0.0 | 2.7 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.1 | 2.6 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.3 | 2.2 | GO:0042825 | TAP complex(GO:0042825) |
| 0.0 | 2.2 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.5 | GO:0008270 | zinc ion binding(GO:0008270) |
| 0.1 | 8.2 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 0.6 | 6.3 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.0 | 5.7 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.0 | 4.1 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 1.0 | 3.9 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 0.1 | 3.9 | GO:0043531 | ADP binding(GO:0043531) |
| 0.0 | 3.9 | GO:0001046 | core promoter sequence-specific DNA binding(GO:0001046) |
| 0.1 | 3.5 | GO:0005242 | inward rectifier potassium channel activity(GO:0005242) |
| 0.9 | 2.8 | GO:0009041 | uridylate kinase activity(GO:0009041) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.6 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 3.3 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.3 | 2.4 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.1 | 2.1 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 2.0 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 1.9 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.0 | 1.9 | ST PHOSPHOINOSITIDE 3 KINASE PATHWAY | PI3K Pathway |
| 0.0 | 1.7 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.1 | 1.5 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.0 | 1.5 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.6 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 3.9 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.1 | 3.5 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.2 | 2.4 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |
| 0.1 | 2.0 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.1 | 1.9 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.0 | 1.7 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.1 | 1.6 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.1 | 1.5 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.2 | 1.4 | REACTOME DEFENSINS | Genes involved in Defensins |